SIMILAR PATTERNS OF AMINO ACIDS FOR 4AN2_A_EUIA1382_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nd4 AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E

(Klebsiella
pneumoniae) 		PF01636
(APH) 		6 LEU A  60
LEU A  92
ASP A 190
ASN A 195
ASP A 208
GLY A 210
 None
None
KAN  A1300 ( 2.8A)
MG  A 400 (-2.7A)
MG  A 400 (-3.2A)
None
 1.29A 4an2A-1nd4A:
7.0		 4an2A-1nd4A:
21.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1s9i DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		11 LYS A 101
LEU A 119
LEU A 122
ILE A 145
MET A 147
ASP A 194
LYS A 196
ASN A 199
ASP A 212
GLY A 214
VAL A 215
 ATP  A 535 ( 2.5A)
5EA  A1001 (-4.9A)
5EA  A1001 (-4.9A)
5EA  A1001 ( 3.7A)
ATP  A 535 ( 3.4A)
ATP  A 535 ( 3.4A)
ATP  A 535 (-2.7A)
MG  A 536 (-2.8A)
MG  A 536 (-3.3A)
5EA  A1001 (-3.6A)
5EA  A1001 (-3.9A)
 0.47A 4an2A-1s9iA:
39.5		 4an2A-1s9iA:
74.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bgs ALDOSE REDUCTASE

(Hordeum vulgare) 		PF00248
(Aldo_ket_red) 		6 LEU A 173
LEU A 176
ASP A 162
GLY A 164
VAL A 165
GLY A  21
 None
 1.45A 4an2A-2bgsA:
undetectable		 4an2A-2bgsA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		6 LYS A 295
LEU A 325
ILE A 336
ASP A 386
ASN A 391
GLY A 406
 H8H  A 534 (-3.7A)
None
H8H  A 534 ( 4.5A)
None
H8H  A 534 ( 4.9A)
None
 1.04A 4an2A-2h8hA:
26.0		 4an2A-2h8hA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hck HEMATOPOETIC CELL
KINASE HCK

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		7 LYS A 295
LEU A 325
ILE A 336
ASP A 386
ASN A 391
ASP A 404
GLY A 406
 None
 1.02A 4an2A-2hckA:
26.3		 4an2A-2hckA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iu4 DIHYDROXYACETONE
KINASE

(Lactococcus
lactis) 		PF02733
(Dak1) 		6 LEU A  25
LEU A  34
ILE A  18
MET A  14
VAL A  62
GLY A 292
 None
 1.39A 4an2A-2iu4A:
undetectable		 4an2A-2iu4A:
26.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ji9 OXALYL-COA
DECARBOXYLASE

(Oxalobacter
formigenes) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		5 LEU A 529
LEU A 525
ILE A 475
GLY A 382
VAL A 383
 None
 0.75A 4an2A-2ji9A:
undetectable		 4an2A-2ji9A:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pzi PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNG

(Mycobacterium
tuberculosis) 		PF00069
(Pkinase)
PF16918
(PknG_TPR)
PF16919
(PknG_rubred) 		7 LYS A 181
ILE A 230
MET A 232
ASP A 276
LYS A 278
ASN A 281
ASP A 293
 AXX  A 753 ( 4.3A)
None
AXX  A 753 (-3.6A)
None
None
None
AXX  A 753 ( 4.4A)
 0.92A 4an2A-2pziA:
8.8		 4an2A-2pziA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pzi PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNG

(Mycobacterium
tuberculosis) 		PF00069
(Pkinase)
PF16918
(PknG_TPR)
PF16919
(PknG_rubred) 		7 LYS A 181
LEU A 202
ILE A 230
MET A 232
LYS A 278
ASN A 281
ASP A 293
 AXX  A 753 ( 4.3A)
None
None
AXX  A 753 (-3.6A)
None
None
AXX  A 753 ( 4.4A)
 1.03A 4an2A-2pziA:
8.8		 4an2A-2pziA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qlu ACTIVIN RECEPTOR
TYPE IIB

(Homo sapiens) 		PF00069
(Pkinase) 		5 LYS A 217
ASP A 321
LYS A 323
ASN A 326
ASP A 339
 None
None
SO4  A   2 (-3.0A)
None
None
 0.76A 4an2A-2qluA:
22.4		 4an2A-2qluA:
28.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w9f CELL DIVISION
PROTEIN KINASE 4

(Homo sapiens) 		PF00069
(Pkinase) 		6 LYS B  35
ASP B 140
LYS B 142
ASN B 145
ASP B 158
GLY B 160
 None
 1.17A 4an2A-2w9fB:
23.6		 4an2A-2w9fB:
29.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w9f CELL DIVISION
PROTEIN KINASE 4

(Homo sapiens) 		PF00069
(Pkinase) 		6 LYS B  35
LEU B  60
ASP B 140
LYS B 142
ASN B 145
ASP B 158
 None
 1.29A 4an2A-2w9fB:
23.6		 4an2A-2w9fB:
29.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wbm RIBOSOME MATURATION
PROTEIN SDO1 HOMOLOG

(Methanothermobacter
thermautotrophicus) 		PF01172
(SBDS)
PF09377
(SBDS_C) 		5 LEU A 218
LEU A 221
ILE A 171
GLY A 181
VAL A 182
 None
 0.76A 4an2A-2wbmA:
undetectable		 4an2A-2wbmA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y7j PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A  81
ASP A 153
LYS A 155
ASN A 158
ASP A 171
 None
None
None
None
B49  A1294 (-4.2A)
 0.67A 4an2A-2y7jA:
25.1		 4an2A-2y7jA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3coi MITOGEN-ACTIVATED
PROTEIN KINASE 13

(Homo sapiens) 		PF00069
(Pkinase) 		5 ASP A 150
LYS A 152
ASN A 155
ASP A 168
GLY A 170
 None
 0.73A 4an2A-3coiA:
20.5		 4an2A-3coiA:
27.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dtc MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 9

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 MET A 220
ASP A 268
LYS A 270
ASN A 273
GLY A 296
GLY A 311
 VIN  A6331 (-3.7A)
SO4  A8001 ( 4.8A)
SO4  A8001 (-3.0A)
VIN  A6331 ( 4.8A)
None
None
 0.97A 4an2A-3dtcA:
25.9		 4an2A-3dtcA:
28.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dxn CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE ISOFORM 3

(Toxoplasma
gondii) 		PF00069
(Pkinase) 		6 LEU A  75
MET A 100
ASP A 146
LYS A 148
ASN A 151
ASP A 167
 None
 0.78A 4an2A-3dxnA:
27.1		 4an2A-3dxnA:
28.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dxn CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE ISOFORM 3

(Toxoplasma
gondii) 		PF00069
(Pkinase) 		6 LEU A  86
ASP A 146
LYS A 148
ASN A 151
ASP A 167
GLY A 169
 None
 0.95A 4an2A-3dxnA:
27.1		 4an2A-3dxnA:
28.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dxn CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE ISOFORM 3

(Toxoplasma
gondii) 		PF00069
(Pkinase) 		6 MET A 100
ASP A 146
LYS A 148
ASN A 151
ASP A 167
GLY A 169
 None
 0.68A 4an2A-3dxnA:
27.1		 4an2A-3dxnA:
28.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eat PYOVERDINE
BIOSYNTHESIS PROTEIN
PVCB

(Pseudomonas
aeruginosa) 		PF02668
(TauD) 		6 LEU X  58
LEU X 249
ILE X 251
ASP X  76
GLY X  39
VAL X  38
 None
 1.18A 4an2A-3eatX:
undetectable		 4an2A-3eatX:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eo3 BIFUNCTIONAL
UDP-N-ACETYLGLUCOSAM
INE
2-EPIMERASE/N-ACETYL
MANNOSAMINE KINASE

(Homo sapiens) 		PF00480
(ROK) 		6 LEU A 504
ILE A 449
ASP A 515
GLY A 471
VAL A 470
GLY A 518
 None
 1.24A 4an2A-3eo3A:
undetectable		 4an2A-3eo3A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gbz KINASE, CMGC CDK

(Giardia
intestinalis) 		PF00069
(Pkinase) 		6 LYS A  44
ASP A 136
LYS A 138
ASN A 141
ASP A 159
GLY A 161
 None
 1.25A 4an2A-3gbzA:
24.5		 4an2A-3gbzA:
25.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gbz KINASE, CMGC CDK

(Giardia
intestinalis) 		PF00069
(Pkinase) 		6 LYS A  44
LEU A  66
ASP A 136
LYS A 138
ASN A 141
ASP A 159
 None
 1.36A 4an2A-3gbzA:
24.5		 4an2A-3gbzA:
25.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hzt CALCIUM-DEPENDENT
PROTEIN KINASE 3

(Toxoplasma
gondii) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		6 LYS A 105
LEU A 128
MET A 153
ASP A 199
ASN A 204
ASP A 220
 GOL  A   1 (-2.7A)
None
GOL  A   1 ( 3.0A)
None
GOL  A 542 ( 4.8A)
J60  A 540 ( 3.6A)
 1.47A 4an2A-3hztA:
22.0		 4an2A-3hztA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hzt CALCIUM-DEPENDENT
PROTEIN KINASE 3

(Toxoplasma
gondii) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		7 LYS A 105
LEU A 128
MET A 153
ASP A 199
LYS A 201
ASN A 204
ASP A 220
 GOL  A   1 (-2.7A)
None
GOL  A   1 ( 3.0A)
None
None
GOL  A 542 ( 4.8A)
J60  A 540 ( 3.6A)
 1.26A 4an2A-3hztA:
22.0		 4an2A-3hztA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3is5 CALCIUM-DEPENDENT
PROTEIN KINASE

(Toxoplasma
gondii) 		PF00069
(Pkinase) 		6 LYS A 164
ILE A 208
MET A 210
ASP A 260
ASN A 265
ASP A 281
 GOL  A 398 ( 3.1A)
None
GOL  A 398 ( 3.6A)
None
MG  A 399 (-3.0A)
MG  A 399 ( 3.0A)
 0.93A 4an2A-3is5A:
19.1		 4an2A-3is5A:
27.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  84
ASP A 158
LYS A 160
ASN A 163
ASP A 179
GLY A 197
 QUE  A   1 ( 4.6A)
None
None
None
QUE  A   1 (-2.9A)
None
 1.09A 4an2A-3lm5A:
24.1		 4an2A-3lm5A:
26.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A 108
LEU A  84
ASP A 158
LYS A 160
ASN A 163
ASP A 179
 None
QUE  A   1 ( 4.6A)
None
None
None
QUE  A   1 (-2.9A)
 1.47A 4an2A-3lm5A:
24.1		 4an2A-3lm5A:
26.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A 108
LEU A  84
LYS A 160
ASN A 163
ASP A 179
GLY A 181
 None
QUE  A   1 ( 4.6A)
None
None
QUE  A   1 (-2.9A)
None
 1.42A 4an2A-3lm5A:
24.1		 4an2A-3lm5A:
26.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A 108
LEU A 110
ASP A 158
LYS A 160
ASN A 163
ASP A 179
 None
QUE  A   1 (-4.1A)
None
None
None
QUE  A   1 (-2.9A)
 1.45A 4an2A-3lm5A:
24.1		 4an2A-3lm5A:
26.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o0d TRIACYLGLYCEROL
LIPASE

(Yarrowia
lipolytica) 		PF01764
(Lipase_3)
PF03893
(Lipase3_N) 		6 LEU A 170
LEU A 169
ILE A 173
ASN A 199
GLY A 193
VAL A 192
 None
None
None
None
None
K  A 308 ( 4.6A)
 1.19A 4an2A-3o0dA:
undetectable		 4an2A-3o0dA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rc0 N-LYSINE
METHYLTRANSFERASE
SETD6

(Homo sapiens) 		PF00856
(SET)
PF09273
(Rubis-subs-bind) 		6 LEU A 468
LEU A 465
ILE A 356
ASP A 312
VAL A 420
GLY A 349
 None
 1.33A 4an2A-3rc0A:
undetectable		 4an2A-3rc0A:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rw9 SPERMIDINE SYNTHASE

(Homo sapiens) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		6 LEU A 151
ILE A 130
ASP A 126
GLY A 154
VAL A 153
GLY A 179
 None
 1.45A 4an2A-3rw9A:
undetectable		 4an2A-3rw9A:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3she MAP KINASE-ACTIVATED
PROTEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		5 LYS A  73
ILE A 116
MET A 118
ASP A 166
ASN A 171
 I85  A 350 (-2.8A)
None
I85  A 350 ( 3.9A)
None
I85  A 350 (-4.4A)
 0.75A 4an2A-3sheA:
18.3		 4an2A-3sheA:
25.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3vn9 DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 6

(Homo sapiens) 		PF00069
(Pkinase) 		7 LYS A  82
ILE A 127
MET A 129
ASP A 179
LYS A 181
ASN A 184
ASP A 197
 ANK  A 401 (-2.4A)
None
ANK  A 401 (-3.7A)
ANK  A 401 (-3.7A)
ANK  A 401 (-2.5A)
ANK  A 401 ( 2.7A)
MG  A 402 ( 2.8A)
 0.75A 4an2A-3vn9A:
33.7		 4an2A-3vn9A:
39.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3vn9 DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 6

(Homo sapiens) 		PF00069
(Pkinase) 		7 LYS A  82
MET A 129
ASP A 179
LYS A 181
ASN A 184
ASP A 197
GLY A 199
 ANK  A 401 (-2.4A)
ANK  A 401 (-3.7A)
ANK  A 401 (-3.7A)
ANK  A 401 (-2.5A)
ANK  A 401 ( 2.7A)
MG  A 402 ( 2.8A)
None
 0.80A 4an2A-3vn9A:
33.7		 4an2A-3vn9A:
39.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3wig DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		8 LYS A  98
LEU A 116
ILE A 142
ASP A 191
LYS A 193
ASN A 196
ASP A 209
GLY A 211
 ANP  A 401 (-2.7A)
None
CHU  A 403 (-3.8A)
CHU  A 403 (-3.6A)
ANP  A 401 (-3.0A)
MG  A 402 ( 2.9A)
MG  A 402 (-3.2A)
CHU  A 403 ( 3.3A)
 1.50A 4an2A-3wigA:
40.7		 4an2A-3wigA:
94.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3wig DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		11 LYS A  98
LEU A 116
LEU A 119
ILE A 142
MET A 144
ASP A 191
LYS A 193
ASN A 196
ASP A 209
GLY A 211
VAL A 212
 ANP  A 401 (-2.7A)
None
CHU  A 403 (-4.4A)
CHU  A 403 (-3.8A)
CHU  A 403 (-3.8A)
CHU  A 403 (-3.6A)
ANP  A 401 (-3.0A)
MG  A 402 ( 2.9A)
MG  A 402 (-3.2A)
CHU  A 403 ( 3.3A)
CHU  A 403 ( 4.0A)
 0.48A 4an2A-3wigA:
40.7		 4an2A-3wigA:
94.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4agu CYCLIN-DEPENDENT
KINASE-LIKE 1

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  78
LEU A  55
ASP A 126
LYS A 128
ASN A 131
GLY A 146
 None
None
None
D15  A 500 ( 4.8A)
D15  A 500 (-3.0A)
None
 1.48A 4an2A-4aguA:
24.1		 4an2A-4aguA:
28.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aw2 SERINE/THREONINE-PRO
TEIN KINASE MRCK
ALPHA

(Rattus
norvegicus) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		6 LEU A 108
LEU A 152
ASP A 201
LYS A 203
ASN A 206
GLY A 221
 EDO  A1419 (-4.2A)
None
None
None
None
EDO  A1419 (-3.7A)
 1.24A 4an2A-4aw2A:
22.3		 4an2A-4aw2A:
24.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aw2 SERINE/THREONINE-PRO
TEIN KINASE MRCK
ALPHA

(Rattus
norvegicus) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		6 LEU A 152
LEU A 129
ASP A 201
LYS A 203
ASN A 206
GLY A 221
 None
None
None
None
None
EDO  A1419 (-3.7A)
 1.37A 4an2A-4aw2A:
22.3		 4an2A-4aw2A:
24.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c02 ACTIVIN RECEPTOR
TYPE-1

(Homo sapiens) 		PF00069
(Pkinase)
PF08515
(TGF_beta_GS) 		6 LEU A 281
ASP A 336
LYS A 338
ASN A 341
ASP A 354
GLY A 356
 None
None
FLC  A1504 (-2.8A)
None
TAK  A1507 (-3.5A)
None
 1.33A 4an2A-4c02A:
22.5		 4an2A-4c02A:
26.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c02 ACTIVIN RECEPTOR
TYPE-1

(Homo sapiens) 		PF00069
(Pkinase)
PF08515
(TGF_beta_GS) 		5 LYS A 235
ASP A 336
LYS A 338
ASN A 341
ASP A 354
 TAK  A1507 ( 4.5A)
None
FLC  A1504 (-2.8A)
None
TAK  A1507 (-3.5A)
 0.65A 4an2A-4c02A:
22.5		 4an2A-4c02A:
26.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ejy 3-METHYLADENINE DNA
GLYCOSYLASE

(Caldanaerobacter
subterraneus) 		PF00730
(HhH-GPD)
PF07934
(OGG_N) 		6 LEU A 212
LEU A 118
ILE A 195
ASP A 185
GLY A 217
VAL A 218
 None
None
None
None
NA  A 301 ( 4.9A)
NA  A 301 (-4.6A)
 1.47A 4an2A-4ejyA:
undetectable		 4an2A-4ejyA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eqm PROTEIN KINASE

(Staphylococcus
aureus) 		PF00069
(Pkinase) 		6 LYS A  39
MET A  87
ASP A 133
LYS A 135
ASN A 138
ASP A 151
 ANP  A 300 (-3.1A)
ANP  A 300 (-3.6A)
None
None
None
None
 0.88A 4an2A-4eqmA:
25.3		 4an2A-4eqmA:
26.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fg8 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1

(Homo sapiens) 		PF00069
(Pkinase) 		6 LYS A  49
LEU A  70
MET A  95
ASP A 141
LYS A 143
ASN A 146
 ATP  A 401 (-3.0A)
None
ATP  A 401 ( 4.3A)
ATP  A 401 ( 4.6A)
None
ATP  A 401 (-3.4A)
 1.05A 4an2A-4fg8A:
24.1		 4an2A-4fg8A:
26.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fl3 TYROSINE-PROTEIN
KINASE SYK

(Homo sapiens) 		PF00017
(SH2)
PF07714
(Pkinase_Tyr) 		5 LYS A 402
MET A 448
ASN A 499
ASP A 512
GLY A 514
 ANP  A 701 (-2.7A)
ANP  A 701 ( 3.7A)
MG  A 702 ( 3.0A)
MG  A 702 ( 3.1A)
None
 0.56A 4an2A-4fl3A:
25.8		 4an2A-4fl3A:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g3f NF-KAPPA-BETA-INDUCI
NG KINASE

(Mus musculus) 		PF00069
(Pkinase) 		6 LEU A 443
LEU A 457
ILE A 469
ASN A 522
ASP A 536
GLY A 560
 None
None
0WB  A 701 (-3.9A)
0WB  A 701 (-4.1A)
0WB  A 701 (-3.1A)
None
 1.08A 4an2A-4g3fA:
25.7		 4an2A-4g3fA:
27.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g3f NF-KAPPA-BETA-INDUCI
NG KINASE

(Mus musculus) 		PF00069
(Pkinase) 		6 LEU A 457
ILE A 469
ASP A 517
LYS A 519
ASN A 522
ASP A 536
 None
0WB  A 701 (-3.9A)
None
None
0WB  A 701 (-4.1A)
0WB  A 701 (-3.1A)
 1.16A 4an2A-4g3fA:
25.7		 4an2A-4g3fA:
27.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g3f NF-KAPPA-BETA-INDUCI
NG KINASE

(Mus musculus) 		PF00069
(Pkinase) 		6 LYS A 431
ILE A 469
ASP A 517
LYS A 519
ASN A 522
ASP A 536
 0WB  A 701 (-3.0A)
0WB  A 701 (-3.9A)
None
None
0WB  A 701 (-4.1A)
0WB  A 701 (-3.1A)
 1.05A 4an2A-4g3fA:
25.7		 4an2A-4g3fA:
27.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g3f NF-KAPPA-BETA-INDUCI
NG KINASE

(Mus musculus) 		PF00069
(Pkinase) 		6 LYS A 431
LEU A 443
ILE A 469
ASN A 522
ASP A 536
GLY A 560
 0WB  A 701 (-3.0A)
None
0WB  A 701 (-3.9A)
0WB  A 701 (-4.1A)
0WB  A 701 (-3.1A)
None
 1.24A 4an2A-4g3fA:
25.7		 4an2A-4g3fA:
27.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g3f NF-KAPPA-BETA-INDUCI
NG KINASE

(Mus musculus) 		PF00069
(Pkinase) 		6 LYS A 431
MET A 471
ASP A 517
LYS A 519
ASN A 522
ASP A 536
 0WB  A 701 (-3.0A)
0WB  A 701 (-3.9A)
None
None
0WB  A 701 (-4.1A)
0WB  A 701 (-3.1A)
 1.16A 4an2A-4g3fA:
25.7		 4an2A-4g3fA:
27.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gv1 RAC-ALPHA
SERINE/THREONINE-PRO
TEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		6 MET A 227
ASP A 274
LYS A 276
ASN A 279
ASP A 292
VAL A 201
 0XZ  A 501 (-3.8A)
None
0XZ  A 501 ( 4.4A)
0XZ  A 501 ( 4.5A)
0XZ  A 501 ( 3.4A)
None
 1.19A 4an2A-4gv1A:
25.3		 4an2A-4gv1A:
25.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hyv PYRUVATE KINASE 1

(Trypanosoma
brucei) 		PF00224
(PK)
PF02887
(PK_C) 		6 LEU A 198
ILE A 209
ASN A  52
ASP A  84
GLY A  87
GLY A 264
 None
None
K  A1002 (-3.3A)
K  A1002 (-3.4A)
None
PEP  A1003 (-3.3A)
 1.35A 4an2A-4hyvA:
undetectable		 4an2A-4hyvA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4idt MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 14

(Homo sapiens) 		PF00069
(Pkinase) 		5 ILE A 467
MET A 469
ASP A 515
LYS A 517
ASN A 520
 None
T28  A 701 (-2.6A)
None
None
T28  A 701 ( 4.9A)
 0.63A 4an2A-4idtA:
25.4		 4an2A-4idtA:
26.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4idt MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 14

(Homo sapiens) 		PF00069
(Pkinase) 		6 LYS A 429
LEU A 441
ILE A 467
ASN A 520
ASP A 534
GLY A 558
 T28  A 701 ( 3.8A)
None
None
T28  A 701 ( 4.9A)
T28  A 701 ( 3.4A)
None
 1.46A 4an2A-4idtA:
25.4		 4an2A-4idtA:
26.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4idt MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 14

(Homo sapiens) 		PF00069
(Pkinase) 		6 LYS A 429
LEU A 441
ILE A 467
ASP A 515
ASN A 520
ASP A 534
 T28  A 701 ( 3.8A)
None
None
None
T28  A 701 ( 4.9A)
T28  A 701 ( 3.4A)
 1.15A 4an2A-4idtA:
25.4		 4an2A-4idtA:
26.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4idt MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 14

(Homo sapiens) 		PF00069
(Pkinase) 		6 LYS A 429
LEU A 441
ILE A 467
MET A 469
ASN A 520
GLY A 558
 T28  A 701 ( 3.8A)
None
None
T28  A 701 (-2.6A)
T28  A 701 ( 4.9A)
None
 1.31A 4an2A-4idtA:
25.4		 4an2A-4idtA:
26.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4idt MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 14

(Homo sapiens) 		PF00069
(Pkinase) 		6 LYS A 429
LEU A 441
ILE A 467
MET A 469
ASP A 515
ASN A 520
 T28  A 701 ( 3.8A)
None
None
T28  A 701 (-2.6A)
None
T28  A 701 ( 4.9A)
 0.94A 4an2A-4idtA:
25.4		 4an2A-4idtA:
26.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4idt MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 14

(Homo sapiens) 		PF00069
(Pkinase) 		6 LYS A 429
LEU A 441
LEU A 455
ILE A 467
ASP A 515
ASP A 534
 T28  A 701 ( 3.8A)
None
None
None
None
T28  A 701 ( 3.4A)
 1.40A 4an2A-4idtA:
25.4		 4an2A-4idtA:
26.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k11 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		6 LYS A 295
ILE A 336
ASP A 386
ASN A 391
ASP A 404
GLY A 406
 0J9  A 601 ( 4.7A)
0J9  A 601 (-4.4A)
None
None
0J9  A 601 (-3.1A)
None
 0.57A 4an2A-4k11A:
25.9		 4an2A-4k11A:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lrj EFFECTOR NLEH1

(Escherichia
coli) 		no annotation 6 LYS A 159
ILE A 199
MET A 201
ASP A 239
ASN A 244
ASP A 258
 ANP  A 301 (-3.6A)
None
ANP  A 301 (-3.5A)
None
MG  A 302 ( 4.4A)
MG  A 302 ( 2.9A)
 0.92A 4an2A-4lrjA:
8.4		 4an2A-4lrjA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m69 RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 3

(Mus musculus) 		PF00069
(Pkinase) 		6 LYS A  51
ASP A 143
LYS A 145
ASN A 148
ASP A 161
GLY A 163
 ANP  A 401 (-2.9A)
ANP  A 401 (-2.6A)
ANP  A 401 (-3.0A)
MG  A 403 ( 2.6A)
MG  A 403 ( 3.1A)
None
 0.72A 4an2A-4m69A:
25.9		 4an2A-4m69A:
27.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m69 RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 3

(Mus musculus) 		PF00069
(Pkinase) 		6 LYS A  51
LEU A  76
ASP A 143
LYS A 145
ASN A 148
ASP A 161
 ANP  A 401 (-2.9A)
None
ANP  A 401 (-2.6A)
ANP  A 401 (-3.0A)
MG  A 403 ( 2.6A)
MG  A 403 ( 3.1A)
 1.04A 4an2A-4m69A:
25.9		 4an2A-4m69A:
27.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ow8 SERINE/THREONINE-PRO
TEIN KINASE PKNA

(Mycobacterium
tuberculosis) 		PF00069
(Pkinase) 		8 LYS A  42
MET A  95
ASP A 141
LYS A 143
ASN A 146
ASP A 159
GLY A 161
GLY A 179
 None
 1.05A 4an2A-4ow8A:
25.0		 4an2A-4ow8A:
27.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4psw HISTONE
ACETYLTRANSFERASE
TYPE B CATALYTIC
SUBUNIT

(Saccharomyces
cerevisiae) 		PF00583
(Acetyltransf_1)
PF10394
(Hat1_N) 		5 LEU A  91
LEU A  87
ILE A 155
VAL A  67
GLY A  25
 None
 0.71A 4an2A-4pswA:
undetectable		 4an2A-4pswA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q9z HUMAN PROTEIN KINASE
C THETA

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		5 LEU A 432
ASP A 504
LYS A 506
ASN A 509
ASP A 522
 None
None
None
PZW  A 801 (-4.4A)
PZW  A 801 (-3.2A)
 0.74A 4an2A-4q9zA:
23.6		 4an2A-4q9zA:
27.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rgj CALCIUM-DEPENDENT
PROTEIN KINASE 4

(Plasmodium
falciparum) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		5 LYS A  99
LYS A 195
ASN A 198
ASP A 215
GLY A 217
 None
 0.74A 4an2A-4rgjA:
23.6		 4an2A-4rgjA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uy9 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 9

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A 218
ASP A 268
LYS A 270
ASN A 273
ASP A 294
GLY A 296
 None
 1.21A 4an2A-4uy9A:
25.8		 4an2A-4uy9A:
27.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wb7 DNAJ HOMOLOG
SUBFAMILY B MEMBER
1,CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA

(Homo sapiens) 		PF00069
(Pkinase)
PF00226
(DnaJ) 		5 LYS A 127
MET A 175
ASP A 221
LYS A 223
ASN A 226
 ATP  A 501 (-2.6A)
ATP  A 501 (-3.6A)
ATP  A 501 (-4.2A)
ATP  A 501 (-2.7A)
ZN  A 502 ( 2.5A)
 0.67A 4an2A-4wb7A:
24.8		 4an2A-4wb7A:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wsq AP2-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		5 ILE A 124
MET A 126
ASP A 176
LYS A 178
ASN A 181
 None
KSA  A 405 ( 3.7A)
ZN  A 403 (-3.2A)
ZN  A 403 ( 4.3A)
KSA  A 405 (-4.0A)
 0.70A 4an2A-4wsqA:
23.2		 4an2A-4wsqA:
26.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x3f SERINE/THREONINE-PRO
TEIN KINASE PKNA

(Mycobacterium
tuberculosis) 		PF00069
(Pkinase) 		6 LEU A  44
LEU A  93
ASN A 146
ASP A 159
GLY A 161
GLY A 179
 None
 1.42A 4an2A-4x3fA:
24.5		 4an2A-4x3fA:
27.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y0x SERINE/THREONINE-PRO
TEIN KINASE PKNG

(Mycobacterium
tuberculosis) 		PF00069
(Pkinase)
PF16919
(PknG_rubred) 		6 ILE A 230
MET A 232
ASP A 276
LYS A 278
ASN A 281
GLY A 308
 None
ADP  A 501 (-3.3A)
None
MG  A 503 ( 4.8A)
MG  A 503 ( 2.9A)
None
 1.20A 4an2A-4y0xA:
15.3		 4an2A-4y0xA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y0x SERINE/THREONINE-PRO
TEIN KINASE PKNG

(Mycobacterium
tuberculosis) 		PF00069
(Pkinase)
PF16919
(PknG_rubred) 		6 LYS A 181
ILE A 230
MET A 232
ASP A 276
LYS A 278
ASN A 281
 ADP  A 501 (-2.7A)
None
ADP  A 501 (-3.3A)
None
MG  A 503 ( 4.8A)
MG  A 503 ( 2.9A)
 0.86A 4an2A-4y0xA:
15.3		 4an2A-4y0xA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y0x SERINE/THREONINE-PRO
TEIN KINASE PKNG

(Mycobacterium
tuberculosis) 		PF00069
(Pkinase)
PF16919
(PknG_rubred) 		6 LYS A 181
LEU A 202
ILE A 230
LYS A 278
ASN A 281
ASP A 293
 ADP  A 501 (-2.7A)
None
None
MG  A 503 ( 4.8A)
MG  A 503 ( 2.9A)
MG  A 504 (-2.3A)
 1.18A 4an2A-4y0xA:
15.3		 4an2A-4y0xA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y0x SERINE/THREONINE-PRO
TEIN KINASE PKNG

(Mycobacterium
tuberculosis) 		PF00069
(Pkinase)
PF16919
(PknG_rubred) 		6 LYS A 181
LEU A 202
ILE A 230
MET A 232
LYS A 278
ASN A 281
 ADP  A 501 (-2.7A)
None
None
ADP  A 501 (-3.3A)
MG  A 503 ( 4.8A)
MG  A 503 ( 2.9A)
 0.98A 4an2A-4y0xA:
15.3		 4an2A-4y0xA:
22.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4yc6 CYCLIN-DEPENDENT
KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  66
ASP A 128
LYS A 130
ASN A 133
ASP A 146
GLY A 148
 None
 1.17A 4an2A-4yc6A:
25.0		 4an2A-4yc6A:
30.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4yc6 CYCLIN-DEPENDENT
KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		6 LYS A  33
ASP A 128
LYS A 130
ASN A 133
ASP A 146
GLY A 148
 None
 0.98A 4an2A-4yc6A:
25.0		 4an2A-4yc6A:
30.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4yc6 CYCLIN-DEPENDENT
KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		6 LYS A  33
LEU A  55
ASP A 128
LYS A 130
ASN A 133
ASP A 146
 None
 1.09A 4an2A-4yc6A:
25.0		 4an2A-4yc6A:
30.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z7g SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1

(Homo sapiens) 		PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A) 		6 LEU A 616
ILE A 640
ASP A 688
LYS A 690
ASN A 693
ASP A 711
 None
 1.03A 4an2A-4z7gA:
19.1		 4an2A-4z7gA:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z7g SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1

(Homo sapiens) 		PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A) 		6 LEU A 616
ILE A 642
ASP A 688
LYS A 690
ASN A 693
ASP A 711
 None
 1.44A 4an2A-4z7gA:
19.1		 4an2A-4z7gA:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hes MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LYS A  45
LEU A  57
ASP A 133
LYS A 135
ASN A 138
ASP A 151
 032  A 401 (-4.4A)
032  A 401 ( 4.7A)
None
None
None
032  A 401 (-4.6A)
 0.97A 4an2A-5hesA:
24.8		 4an2A-5hesA:
24.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hes MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LYS A  45
LEU A  57
ASP A 133
LYS A 135
ASN A 138
ASP A 151
 032  A 401 (-4.4A)
032  A 401 ( 4.7A)
None
None
None
032  A 401 (-4.6A)
 1.34A 4an2A-5hesA:
24.8		 4an2A-5hesA:
24.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hes MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LYS A  45
LEU A  57
ILE A  80
ASP A 133
LYS A 135
ASN A 138
 032  A 401 (-4.4A)
032  A 401 ( 4.7A)
032  A 401 (-4.0A)
None
None
None
 0.89A 4an2A-5hesA:
24.8		 4an2A-5hesA:
24.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hes MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LYS A  45
LEU A  57
ILE A  80
ASP A 133
LYS A 135
ASN A 138
 032  A 401 (-4.4A)
032  A 401 ( 4.7A)
032  A 401 (-4.0A)
None
None
None
 1.35A 4an2A-5hesA:
24.8		 4an2A-5hesA:
24.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i3o BMP-2-INDUCIBLE
PROTEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		6 LYS A  79
ILE A 128
ASP A 180
LYS A 182
ASN A 185
ASP A 198
 IDV  A 401 ( 4.8A)
None
None
IDV  A 401 ( 4.2A)
IDV  A 401 (-4.1A)
IDV  A 401 (-4.0A)
 1.03A 4an2A-5i3oA:
23.2		 4an2A-5i3oA:
27.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i3o BMP-2-INDUCIBLE
PROTEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		6 LYS A  79
ILE A 128
MET A 130
ASP A 180
LYS A 182
ASN A 185
 IDV  A 401 ( 4.8A)
None
IDV  A 401 (-3.4A)
None
IDV  A 401 ( 4.2A)
IDV  A 401 (-4.1A)
 0.79A 4an2A-5i3oA:
23.2		 4an2A-5i3oA:
27.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j0a LYMPHOKINE-ACTIVATED
KILLER
T-CELL-ORIGINATED
PROTEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  89
LEU A  92
ASP A 167
LYS A 169
ASN A 172
ASP A 186
 None
 1.27A 4an2A-5j0aA:
4.3		 4an2A-5j0aA:
26.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k0y EUKARYOTIC
INITIATION FACTOR 2
GAMMA SUBUNIT
(EIF2-GAMMA)

(Oryctolagus
cuniculus) 		PF00009
(GTP_EFTU)
PF03144
(GTP_EFTU_D2)
PF09173
(eIF2_C) 		6 LEU S 269
ILE S 296
ASN S  98
GLY S 351
VAL S 352
GLY S  95
 None
None
None
A  N  75 ( 3.8A)
None
None
 1.38A 4an2A-5k0yS:
undetectable		 4an2A-5k0yS:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m09 SERINE/THREONINE-PRO
TEIN KINASE PKNI

(Mycobacterium
tuberculosis) 		PF00069
(Pkinase) 		6 ILE A  87
MET A  89
ASP A 137
ASN A 142
ASP A 159
GLY A 161
 None
 0.80A 4an2A-5m09A:
21.9		 4an2A-5m09A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m09 SERINE/THREONINE-PRO
TEIN KINASE PKNI

(Mycobacterium
tuberculosis) 		PF00069
(Pkinase) 		6 LYS A  41
ILE A  87
MET A  89
ASN A 142
ASP A 159
GLY A 161
 None
 0.90A 4an2A-5m09A:
21.9		 4an2A-5m09A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mux 2-METHYLCITRATE
DEHYDRATASE

(Bacillus
subtilis) 		no annotation 6 LEU A 261
LEU A 265
ILE A  11
ASN A 108
GLY A 148
VAL A 149
 None
 0.90A 4an2A-5muxA:
undetectable		 4an2A-5muxA:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5myv SRSF PROTEIN KINASE
2,SRSF PROTEIN
KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A 140
ASP A 225
LYS A 227
ASN A 230
ASP A 541
GLY A 543
 None
None
None
None
DMS  A 717 (-4.3A)
None
 1.39A 4an2A-5myvA:
20.2		 4an2A-5myvA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nd1 CAPSID PROTEIN

(Rosellinia
necatrix
quadrivirus 1) 		no annotation 6 LEU B 894
ILE B 893
ASN B 885
GLY B 814
VAL B 815
GLY A 920
 None
 1.21A 4an2A-5nd1B:
undetectable		 4an2A-5nd1B:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23

(Caenorhabditis
elegans) 		no annotation 6 LYS A 919
ILE A 961
ASP A1010
ASN A1015
ASP A1028
GLY A1030
 ANP  A1201 (-3.8A)
None
ANP  A1201 (-3.7A)
MG  A1202 ( 2.9A)
MG  A1202 ( 3.0A)
None
 0.79A 4an2A-5wnoA:
25.4		 4an2A-5wnoA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xv7 SERINE-ARGININE (SR)
PROTEIN KINASE 1

(Homo sapiens) 		no annotation 5 LEU A 128
ASP A 213
LYS A 215
ASN A 218
ASP A 497
 None
EDO  A 702 ( 4.9A)
None
None
EMH  A 705 (-4.7A)
 0.73A 4an2A-5xv7A:
21.4		 4an2A-5xv7A:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xzw SERINE/THREONINE-PRO
TEIN KINASE RAD53

(Saccharomyces
cerevisiae) 		no annotation 5 LEU A 248
ASP A 319
LYS A 321
ASN A 324
ASP A 339
 None
 0.70A 4an2A-5xzwA:
19.4		 4an2A-5xzwA:
23.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6ao5 SERINE/THREONINE-PRO
TEIN KINASE 3

(Homo sapiens) 		no annotation 6 LYS A  56
ILE A  97
MET A  99
LYS A 148
ASN A 151
ASP A 164
 ANP  A 501 (-2.4A)
None
ANP  A 501 (-2.5A)
ANP  A 501 (-3.1A)
ANP  A 501 ( 2.6A)
MG  A 502 ( 3.1A)
 0.60A 4an2A-6ao5A:
29.2		 4an2A-6ao5A:
33.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eqi SERINE/THREONINE-PRO
TEIN KINASE PINK1,
PUTATIVE

(Pediculus
humanus) 		no annotation 6 LYS C 193
MET C 290
ASP C 334
ASN C 339
ASP C 357
VAL C 216
 None
 1.21A 4an2A-6eqiC:
19.8		 4an2A-6eqiC:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f3d INTERLEUKIN-1
RECEPTOR-ASSOCIATED
KINASE 4

(Homo sapiens) 		no annotation 6 LEU A 215
LEU A 260
ASP A 311
LYS A 313
ASN A 316
GLY A 331
 None
 1.27A 4an2A-6f3dA:
20.2		 4an2A-6f3dA:
14.29