SIMILAR PATTERNS OF AMINO ACIDS FOR 4AMJ_B_CVDB1360

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gwi CYTOCHROME P450
154C1

(Streptomyces
coelicolor) 		PF00067
(p450) 		5 LEU A 406
VAL A 278
SER A 286
PHE A 335
TYR A 373
 None
 1.47A 4amjB-1gwiA:
undetectable		 4amjB-1gwiA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1of5 MRNA EXPORT FACTOR
MEX67

(Saccharomyces
cerevisiae) 		no annotation 5 LEU A 465
VAL A 458
SER A 280
ASN A 287
TYR A 303
 None
 1.45A 4amjB-1of5A:
undetectable		 4amjB-1of5A:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1un1 XYLOGLUCAN
ENDOTRANSGLYCOSYLASE

(Populus tremula) 		PF00722
(Glyco_hydro_16)
PF06955
(XET_C) 		5 VAL A 143
SER A  57
SER A 131
PHE A  90
PHE A  88
 None
 1.46A 4amjB-1un1A:
undetectable		 4amjB-1un1A:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vf1 GLUTATHIONE
S-TRANSFERASE 3

(Gallus gallus) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		5 ASP A  93
VAL A  96
TRP A 155
ASN A  73
TYR A  82
 None
 0.89A 4amjB-1vf1A:
undetectable		 4amjB-1vf1A:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zjc AMINOPEPTIDASE AMPS

(Staphylococcus
aureus) 		PF02073
(Peptidase_M29) 		5 LEU A 225
SER A 327
SER A 330
PHE A 406
TYR A 214
 None
 1.49A 4amjB-1zjcA:
undetectable		 4amjB-1zjcA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pbg 6-PHOSPHO-BETA-D-GAL
ACTOSIDASE

(Lactococcus
lactis) 		PF00232
(Glyco_hydro_1) 		5 LEU A 218
SER A 430
SER A 428
PHE A 117
ASN A 159
 None
SO4  A 469 ( 4.4A)
SO4  A 469 (-2.8A)
None
None
 1.44A 4amjB-2pbgA:
undetectable		 4amjB-2pbgA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xsb HYALURONOGLUCOSAMINI
DASE

(Oceanicola
granulosus) 		PF07555
(NAGidase) 		5 LEU A 245
TRP A 251
ASP A 220
VAL A 196
PHE A 320
 None
 1.45A 4amjB-2xsbA:
undetectable		 4amjB-2xsbA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zc0 ALANINE GLYOXYLATE
TRANSAMINASE

(Thermococcus
litoralis) 		PF00155
(Aminotran_1_2) 		5 SER A  38
PHE A 336
ASN A 381
ASN A 186
TYR A 132
 None
None
None
PMP  A 409 (-3.7A)
PMP  A 409 (-3.7A)
 1.36A 4amjB-2zc0A:
undetectable		 4amjB-2zc0A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a5v ALPHA-GALACTOSIDASE

(Umbelopsis
vinacea) 		PF16499
(Melibiase_2) 		5 VAL A 274
SER A  37
SER A  38
TRP A  13
TYR A  19
 None
 1.28A 4amjB-3a5vA:
undetectable		 4amjB-3a5vA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3btz ALPHA-KETOGLUTARATE-
DEPENDENT
DIOXYGENASE ALKB
HOMOLOG 2

(Homo sapiens) 		PF13532
(2OG-FeII_Oxy_2) 		5 LEU A 218
VAL A 108
SER A 125
ASN A 159
TYR A 161
 None
 1.34A 4amjB-3btzA:
undetectable		 4amjB-3btzA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e60 3-OXOACYL-[ACYL-CARR
IER-PROTEIN ]
SYNTHASE II

(Bartonella
henselae) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 LEU A 305
SER A 283
PHE A 404
ASN A 410
ASN A 402
 None
 1.49A 4amjB-3e60A:
undetectable		 4amjB-3e60A:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gdh TRIMETHYLGUANOSINE
SYNTHASE HOMOLOG

(Homo sapiens) 		PF09445
(Methyltransf_15) 		5 LEU A 817
VAL A 685
PHE A 761
PHE A 708
ASN A 704
 None
None
None
None
SAH  A 854 (-4.0A)
 1.38A 4amjB-3gdhA:
undetectable		 4amjB-3gdhA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pbl D(3) DOPAMINE
RECEPTOR, LYSOZYME
CHIMERA

(Escherichia
virus T4;
Homo sapiens) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		8 LEU A  89
ASP A 110
SER A 192
SER A 196
TRP A 342
PHE A 345
PHE A 346
TYR A 373
 None
ETQ  A1200 (-3.5A)
ETQ  A1200 (-3.3A)
ETQ  A1200 ( 4.6A)
None
ETQ  A1200 (-4.4A)
ETQ  A1200 ( 4.5A)
ETQ  A1200 (-4.4A)
 0.77A 4amjB-3pblA:
32.4		 4amjB-3pblA:
29.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pbl D(3) DOPAMINE
RECEPTOR, LYSOZYME
CHIMERA

(Escherichia
virus T4;
Homo sapiens) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		5 LEU A  89
ASP A 110
SER A 196
PHE A 345
PHE A 346
 None
ETQ  A1200 (-3.5A)
ETQ  A1200 ( 4.6A)
ETQ  A1200 (-4.4A)
ETQ  A1200 ( 4.5A)
 1.40A 4amjB-3pblA:
32.4		 4amjB-3pblA:
29.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pds FUSION PROTEIN
BETA-2 ADRENERGIC
RECEPTOR/LYSOZYME

(Escherichia
virus T4;
Homo sapiens) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		5 TRP A 109
ASP A 113
SER A 203
PHE A 290
TYR A 316
 None
ERC  A1201 (-3.7A)
ERC  A1201 (-2.8A)
ERC  A1201 (-4.8A)
None
 1.49A 4amjB-3pdsA:
38.5		 4amjB-3pdsA:
42.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pds FUSION PROTEIN
BETA-2 ADRENERGIC
RECEPTOR/LYSOZYME

(Escherichia
virus T4;
Homo sapiens) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		6 TRP A 109
ASP A 113
SER A 207
PHE A 289
ASN A 312
TYR A 316
 None
ERC  A1201 (-3.7A)
ERC  A1201 (-2.7A)
ERC  A1201 (-4.5A)
ERC  A1201 (-3.0A)
None
 0.93A 4amjB-3pdsA:
38.5		 4amjB-3pdsA:
42.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pds FUSION PROTEIN
BETA-2 ADRENERGIC
RECEPTOR/LYSOZYME

(Escherichia
virus T4;
Homo sapiens) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		10 TRP A 109
ASP A 113
VAL A 117
SER A 203
SER A 207
TRP A 286
PHE A 289
PHE A 290
ASN A 293
TYR A 316
 None
ERC  A1201 (-3.7A)
None
ERC  A1201 (-2.8A)
ERC  A1201 (-2.7A)
None
ERC  A1201 (-4.5A)
ERC  A1201 (-4.8A)
ERC  A1201 (-3.5A)
None
 0.73A 4amjB-3pdsA:
38.5		 4amjB-3pdsA:
42.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pds FUSION PROTEIN
BETA-2 ADRENERGIC
RECEPTOR/LYSOZYME

(Escherichia
virus T4;
Homo sapiens) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		10 TRP A 109
ASP A 113
VAL A 117
SER A 203
TRP A 286
PHE A 289
PHE A 290
ASN A 293
ASN A 312
TYR A 316
 None
ERC  A1201 (-3.7A)
None
ERC  A1201 (-2.8A)
None
ERC  A1201 (-4.5A)
ERC  A1201 (-4.8A)
ERC  A1201 (-3.5A)
ERC  A1201 (-3.0A)
None
 0.69A 4amjB-3pdsA:
38.5		 4amjB-3pdsA:
42.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pds FUSION PROTEIN
BETA-2 ADRENERGIC
RECEPTOR/LYSOZYME

(Escherichia
virus T4;
Homo sapiens) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		5 TRP A 109
ASP A 113
VAL A 117
SER A 204
TYR A 316
 None
ERC  A1201 (-3.7A)
None
ERC  A1201 ( 4.1A)
None
 1.36A 4amjB-3pdsA:
38.5		 4amjB-3pdsA:
42.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pds FUSION PROTEIN
BETA-2 ADRENERGIC
RECEPTOR/LYSOZYME

(Escherichia
virus T4;
Homo sapiens) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		5 VAL A 114
PHE A 289
ASN A 293
ASN A 312
TYR A 316
 ERC  A1201 (-3.8A)
ERC  A1201 (-4.5A)
ERC  A1201 (-3.5A)
ERC  A1201 (-3.0A)
None
 1.19A 4amjB-3pdsA:
38.5		 4amjB-3pdsA:
42.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rze HISTAMINE H1
RECEPTOR, LYSOZYME
CHIMERA

(Escherichia
virus T4;
Homo sapiens) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		5 TRP A 103
ASP A 107
TRP A 428
PHE A 432
TYR A 458
 None
5EH  A1200 ( 2.6A)
5EH  A1200 ( 3.4A)
5EH  A1200 ( 4.3A)
5EH  A1200 ( 4.4A)
 0.66A 4amjB-3rzeA:
30.6		 4amjB-3rzeA:
26.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vrh PUTATIVE
UNCHARACTERIZED
PROTEIN PH0300

(Pyrococcus
horikoshii) 		PF01171
(ATP_bind_3) 		5 LEU A 114
SER A 301
SER A 302
PHE A 142
ASN A 146
 None
 1.41A 4amjB-3vrhA:
undetectable		 4amjB-3vrhA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aoe ACETYLCHOLINE-BINDIN
G PROTEIN TYPE 2

(Biomphalaria
glabrata) 		PF02931
(Neur_chan_LBD) 		5 LEU A 155
VAL A 200
PHE A 124
ASN A  93
TYR A  35
 None
 1.32A 4amjB-4aoeA:
undetectable		 4amjB-4aoeA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bq4 B-AGARASE

(Saccharophagus
degradans) 		PF02449
(Glyco_hydro_42) 		5 LEU A 279
ASP A 768
SER A 337
SER A 420
TYR A 430
 None
 1.43A 4amjB-4bq4A:
undetectable		 4amjB-4bq4A:
16.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4gbr BETA-2 ADRENERGIC
RECEPTOR

(Homo sapiens) 		PF00001
(7tm_1) 		11 TRP A 109
ASP A 113
VAL A 117
SER A 203
SER A 207
TRP A 258
PHE A 261
PHE A 262
ASN A 265
ASN A 284
TYR A 288
 None
CAU  A 500 (-3.0A)
CAU  A 500 (-4.2A)
CAU  A 500 (-3.3A)
CAU  A 500 (-4.1A)
None
CAU  A 500 (-4.2A)
CAU  A 500 (-4.6A)
CAU  A 500 (-3.4A)
CAU  A 500 (-3.3A)
CAU  A 500 (-4.6A)
 0.51A 4amjB-4gbrA:
39.4		 4amjB-4gbrA:
58.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ib4 CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562

(Escherichia
coli;
Homo sapiens) 		PF00001
(7tm_1)
PF07361
(Cytochrom_B562) 		5 TRP A 131
ASP A 135
SER A 222
TRP A 337
TYR A 370
 None
ERM  A2001 (-3.2A)
ERM  A2001 ( 4.6A)
None
ERM  A2001 ( 4.8A)
 1.38A 4amjB-4ib4A:
28.1		 4amjB-4ib4A:
28.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ib4 CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562

(Escherichia
coli;
Homo sapiens) 		PF00001
(7tm_1)
PF07361
(Cytochrom_B562) 		7 TRP A 131
ASP A 135
TRP A 337
PHE A 340
PHE A 341
ASN A 344
TYR A 370
 None
ERM  A2001 (-3.2A)
None
ERM  A2001 (-4.3A)
None
ERM  A2001 (-4.3A)
ERM  A2001 ( 4.8A)
 0.65A 4amjB-4ib4A:
28.1		 4amjB-4ib4A:
28.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lde LYSOZYME, BETA-2
ADRENERGIC RECEPTOR

(Escherichia
virus T4;
Homo sapiens) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		5 TRP A1109
ASP A1113
SER A1203
PHE A1290
TYR A1316
 None
P0G  A1401 (-2.9A)
P0G  A1401 (-2.9A)
P0G  A1401 ( 4.9A)
None
 1.26A 4amjB-4ldeA:
33.0		 4amjB-4ldeA:
42.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lde LYSOZYME, BETA-2
ADRENERGIC RECEPTOR

(Escherichia
virus T4;
Homo sapiens) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		8 TRP A1109
ASP A1113
SER A1203
TRP A1286
PHE A1289
PHE A1290
ASN A1312
TYR A1316
 None
P0G  A1401 (-2.9A)
P0G  A1401 (-2.9A)
None
P0G  A1401 ( 4.7A)
P0G  A1401 ( 4.9A)
P0G  A1401 (-2.9A)
None
 0.79A 4amjB-4ldeA:
33.0		 4amjB-4ldeA:
42.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lde LYSOZYME, BETA-2
ADRENERGIC RECEPTOR

(Escherichia
virus T4;
Homo sapiens) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		5 TRP A1109
ASP A1113
SER A1207
PHE A1289
ASN A1293
 None
P0G  A1401 (-2.9A)
P0G  A1401 (-2.8A)
P0G  A1401 ( 4.7A)
P0G  A1401 (-3.0A)
 1.29A 4amjB-4ldeA:
33.0		 4amjB-4ldeA:
42.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lde LYSOZYME, BETA-2
ADRENERGIC RECEPTOR

(Escherichia
virus T4;
Homo sapiens) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		8 TRP A1109
ASP A1113
TRP A1286
PHE A1289
PHE A1290
ASN A1293
ASN A1312
TYR A1316
 None
P0G  A1401 (-2.9A)
None
P0G  A1401 ( 4.7A)
P0G  A1401 ( 4.9A)
P0G  A1401 (-3.0A)
P0G  A1401 (-2.9A)
None
 0.58A 4amjB-4ldeA:
33.0		 4amjB-4ldeA:
42.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lde LYSOZYME, BETA-2
ADRENERGIC RECEPTOR

(Escherichia
virus T4;
Homo sapiens) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		7 TRP A1109
ASP A1113
VAL A1117
SER A1203
SER A1207
PHE A1289
PHE A1290
 None
P0G  A1401 (-2.9A)
P0G  A1401 ( 4.4A)
P0G  A1401 (-2.9A)
P0G  A1401 (-2.8A)
P0G  A1401 ( 4.7A)
P0G  A1401 ( 4.9A)
 0.92A 4amjB-4ldeA:
33.0		 4amjB-4ldeA:
42.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lde LYSOZYME, BETA-2
ADRENERGIC RECEPTOR

(Escherichia
virus T4;
Homo sapiens) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		8 TRP A1109
ASP A1113
VAL A1117
SER A1203
TRP A1286
PHE A1289
PHE A1290
ASN A1312
 None
P0G  A1401 (-2.9A)
P0G  A1401 ( 4.4A)
P0G  A1401 (-2.9A)
None
P0G  A1401 ( 4.7A)
P0G  A1401 ( 4.9A)
P0G  A1401 (-2.9A)
 0.86A 4amjB-4ldeA:
33.0		 4amjB-4ldeA:
42.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lde LYSOZYME, BETA-2
ADRENERGIC RECEPTOR

(Escherichia
virus T4;
Homo sapiens) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		7 TRP A1109
ASP A1113
VAL A1117
SER A1207
PHE A1289
PHE A1290
ASN A1293
 None
P0G  A1401 (-2.9A)
P0G  A1401 ( 4.4A)
P0G  A1401 (-2.8A)
P0G  A1401 ( 4.7A)
P0G  A1401 ( 4.9A)
P0G  A1401 (-3.0A)
 0.78A 4amjB-4ldeA:
33.0		 4amjB-4ldeA:
42.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lde LYSOZYME, BETA-2
ADRENERGIC RECEPTOR

(Escherichia
virus T4;
Homo sapiens) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		8 TRP A1109
ASP A1113
VAL A1117
TRP A1286
PHE A1289
PHE A1290
ASN A1293
ASN A1312
 None
P0G  A1401 (-2.9A)
P0G  A1401 ( 4.4A)
None
P0G  A1401 ( 4.7A)
P0G  A1401 ( 4.9A)
P0G  A1401 (-3.0A)
P0G  A1401 (-2.9A)
 0.68A 4amjB-4ldeA:
33.0		 4amjB-4ldeA:
42.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lde LYSOZYME, BETA-2
ADRENERGIC RECEPTOR

(Escherichia
virus T4;
Homo sapiens) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		5 VAL A1114
PHE A1289
ASN A1293
ASN A1312
TYR A1316
 P0G  A1401 (-3.7A)
P0G  A1401 ( 4.7A)
P0G  A1401 (-3.0A)
P0G  A1401 (-2.9A)
None
 1.35A 4amjB-4ldeA:
33.0		 4amjB-4ldeA:
42.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5f8u BETA-1 ADRENERGIC
RECEPTOR

(Meleagris
gallopavo) 		no annotation 8 LEU B 101
TRP B 117
ASP B 121
SER B 215
PHE B 306
PHE B 307
ASN B 329
TYR B 333
 None
P32  B 400 (-4.8A)
P32  B 400 (-2.2A)
P32  B 400 ( 4.2A)
P32  B 400 (-4.1A)
P32  B 400 (-4.9A)
P32  B 400 (-2.9A)
P32  B 400 (-4.6A)
 1.09A 4amjB-5f8uB:
40.2		 4amjB-5f8uB:
99.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5f8u BETA-1 ADRENERGIC
RECEPTOR

(Meleagris
gallopavo) 		no annotation 12 LEU B 101
TRP B 117
ASP B 121
VAL B 125
SER B 211
SER B 215
TRP B 303
PHE B 306
PHE B 307
ASN B 310
ASN B 329
TYR B 333
 None
P32  B 400 (-4.8A)
P32  B 400 (-2.2A)
P32  B 400 ( 4.7A)
P32  B 400 (-2.7A)
P32  B 400 ( 4.2A)
None
P32  B 400 (-4.1A)
P32  B 400 (-4.9A)
P32  B 400 (-3.5A)
P32  B 400 (-2.9A)
P32  B 400 (-4.6A)
 0.61A 4amjB-5f8uB:
40.2		 4amjB-5f8uB:
99.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hoe HYDROLASE

(Sinorhizobium
meliloti) 		PF13472
(Lipase_GDSL_2) 		5 LEU A  62
SER A  25
PHE A 156
PHE A 152
TYR A 101
 None
 1.36A 4amjB-5hoeA:
undetectable		 4amjB-5hoeA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i61 POTENTIAL
RNA-DEPENDENT RNA
POLYMERASE

(Human
picobirnavirus) 		no annotation 5 LEU B 285
ASP B 330
SER B 324
PHE B 206
ASN B 211
 None
 1.36A 4amjB-5i61B:
undetectable		 4amjB-5i61B:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ohs -

(-) 		no annotation 5 LEU A 284
VAL A 138
SER A 153
ASN A 523
TYR A 491
 NSQ  A 709 (-3.6A)
None
MPD  A 705 (-3.0A)
None
NSQ  A 709 (-4.2A)
 1.48A 4amjB-5ohsA:
undetectable		 4amjB-5ohsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v54 5-HYDROXYTRYPTAMINE
RECEPTOR 1B,OB-1
FUSED 5-HT1B
RECEPTOR,5-HYDROXYTR
YPTAMINE RECEPTOR 1B

(Homo sapiens;
Spodoptera
frugiperda) 		no annotation 6 TRP A 125
ASP A 129
SER A 212
PHE A 330
PHE A 331
TYR A 359
 None
89F  A1201 (-3.3A)
89F  A1201 ( 3.8A)
89F  A1201 (-4.1A)
89F  A1201 (-4.6A)
None
 1.31A 4amjB-5v54A:
28.7		 4amjB-5v54A:
14.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v54 5-HYDROXYTRYPTAMINE
RECEPTOR 1B,OB-1
FUSED 5-HT1B
RECEPTOR,5-HYDROXYTR
YPTAMINE RECEPTOR 1B

(Homo sapiens;
Spodoptera
frugiperda) 		no annotation 7 TRP A 125
ASP A 129
SER A 212
TRP A 327
PHE A 330
PHE A 331
TYR A 359
 None
89F  A1201 (-3.3A)
89F  A1201 ( 3.8A)
89F  A1201 (-3.6A)
89F  A1201 (-4.1A)
89F  A1201 (-4.6A)
None
 0.81A 4amjB-5v54A:
28.7		 4amjB-5v54A:
14.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vha DEAH
(ASP-GLU-ALA-HIS)
BOX POLYPEPTIDE 36

(Bos taurus) 		no annotation 5 LEU A 625
TRP A 592
ASP A 469
TRP A 445
TYR A 441
 None
 1.45A 4amjB-5vhaA:
undetectable		 4amjB-5vhaA:
10.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5wiv D(4) DOPAMINE
RECEPTOR, SOLUBLE
CYTOCHROME B562
CHIMERA

(Escherichia
coli;
Homo sapiens) 		no annotation 7 ASP A 115
SER A 196
SER A 200
TRP A 407
PHE A 410
PHE A 411
TYR A 438
 AQD  A1201 (-3.3A)
AQD  A1201 (-2.8A)
AQD  A1201 (-3.6A)
None
AQD  A1201 (-4.7A)
AQD  A1201 (-4.6A)
None
 0.80A 4amjB-5wivA:
29.7		 4amjB-5wivA:
32.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bqh 5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562

(Escherichia
coli;
Homo sapiens) 		no annotation 5 TRP A 130
ASP A 134
SER A 219
ASN A 331
TYR A 358
 None
E2J  A1201 (-3.0A)
E2J  A1201 (-3.2A)
None
None
 1.33A 4amjB-6bqhA:
31.6		 4amjB-6bqhA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bqh 5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562

(Escherichia
coli;
Homo sapiens) 		no annotation 6 TRP A 130
ASP A 134
SER A 219
TRP A 324
PHE A 328
TYR A 358
 None
E2J  A1201 (-3.0A)
E2J  A1201 (-3.2A)
E2J  A1201 ( 3.7A)
E2J  A1201 (-4.4A)
None
 1.39A 4amjB-6bqhA:
31.6		 4amjB-6bqhA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bqh 5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562

(Escherichia
coli;
Homo sapiens) 		no annotation 7 TRP A 130
ASP A 134
TRP A 324
PHE A 327
PHE A 328
ASN A 331
TYR A 358
 None
E2J  A1201 (-3.0A)
E2J  A1201 ( 3.7A)
E2J  A1201 (-4.6A)
E2J  A1201 (-4.4A)
None
None
 0.63A 4amjB-6bqhA:
31.6		 4amjB-6bqhA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cm4 D(2) DOPAMINE
RECEPTOR, ENDOLYSIN
CHIMERA

(Escherichia
virus T4;
Homo sapiens) 		no annotation 7 LEU A  94
ASP A 114
SER A 197
TRP A 386
PHE A 389
PHE A 390
TYR A 416
 None
8NU  A2001 ( 3.0A)
8NU  A2001 ( 3.6A)
8NU  A2001 ( 3.8A)
8NU  A2001 ( 4.5A)
8NU  A2001 ( 4.8A)
8NU  A2001 ( 4.9A)
 0.81A 4amjB-6cm4A:
30.6		 4amjB-6cm4A:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g79 5-HYDROXYTRYPTAMINE
RECEPTOR 1B

(Homo sapiens) 		no annotation 6 TRP S 125
ASP S 129
SER S 212
PHE S 330
PHE S 331
TYR S 359
 None
EP5  S 401 (-3.3A)
EP5  S 401 (-3.3A)
EP5  S 401 (-4.0A)
EP5  S 401 (-4.7A)
EP5  S 401 ( 4.9A)
 1.16A 4amjB-6g79S:
28.4		 4amjB-6g79S:
14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g79 5-HYDROXYTRYPTAMINE
RECEPTOR 1B

(Homo sapiens) 		no annotation 7 TRP S 125
ASP S 129
SER S 212
TRP S 327
PHE S 330
PHE S 331
TYR S 359
 None
EP5  S 401 (-3.3A)
EP5  S 401 (-3.3A)
None
EP5  S 401 (-4.0A)
EP5  S 401 (-4.7A)
EP5  S 401 ( 4.9A)
 0.68A 4amjB-6g79S:
28.4		 4amjB-6g79S:
14.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pds FUSION PROTEIN
BETA-2 ADRENERGIC
RECEPTOR/LYSOZYME

(Escherichia
virus T4;
Homo sapiens) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		4 VAL A 114
ASP A 192
TYR A 199
TRP A 313
 ERC  A1201 (-3.8A)
ERC  A1201 (-4.2A)
None
ERC  A1201 (-4.4A)
 0.47A 4amjB-3pdsA:
38.4		 4amjB-3pdsA:
42.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4gbr BETA-2 ADRENERGIC
RECEPTOR

(Homo sapiens) 		PF00001
(7tm_1) 		4 VAL A 114
ASP A 192
TYR A 199
TRP A 285
 CAU  A 500 (-3.5A)
None
None
None
 0.52A 4amjB-4gbrA:
39.4		 4amjB-4gbrA:
58.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lde LYSOZYME, BETA-2
ADRENERGIC RECEPTOR

(Escherichia
virus T4;
Homo sapiens) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		4 VAL A1114
ASP A1192
TYR A1199
TRP A1313
 P0G  A1401 (-3.7A)
None
None
1WV  A1403 ( 4.3A)
 0.97A 4amjB-4ldeA:
33.0		 4amjB-4ldeA:
42.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5f8u BETA-1 ADRENERGIC
RECEPTOR

(Meleagris
gallopavo) 		no annotation 4 VAL B 122
ASP B 200
TYR B 207
TRP B 330
 P32  B 400 (-3.5A)
None
None
None
 0.58A 4amjB-5f8uB:
40.2		 4amjB-5f8uB:
99.37