SIMILAR PATTERNS OF AMINO ACIDS FOR 4AMJ_A_CVDA1359

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1civ NADP-MALATE
DEHYDROGENASE

(Flaveria
bidentis) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 VAL A 167
VAL A 166
SER A  48
PHE A 147
ASN A 143
 NAP  A 386 (-4.7A)
None
NAP  A 386 ( 4.7A)
None
None
 1.41A 4amjA-1civA:
undetectable		 4amjA-1civA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gy9 ALPHA-KETOGLUTARATE-
DEPENDENT TAURINE
DIOXYGENASE

(Escherichia
coli) 		PF02668
(TauD) 		5 TRP A 248
ASP A 101
VAL A 102
PHE A 159
ASN A  95
 None
FE  A 300 (-2.3A)
TAU  A 350 (-3.8A)
TAU  A 350 (-4.3A)
AKG  A 351 ( 3.5A)
 1.03A 4amjA-1gy9A:
undetectable		 4amjA-1gy9A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hfe PROTEIN (FE-ONLY
HYDROGENASE
(E.C.1.18.99.1)
(LARGER SUBUNIT))

(Desulfovibrio
vulgaris) 		PF02906
(Fe_hyd_lg_C)
PF13237
(Fer4_10) 		5 VAL L 359
SER L 368
TRP L 182
PHE L 175
TYR L 185
 None
 1.43A 4amjA-1hfeL:
undetectable		 4amjA-1hfeL:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1un1 XYLOGLUCAN
ENDOTRANSGLYCOSYLASE

(Populus tremula) 		PF00722
(Glyco_hydro_16)
PF06955
(XET_C) 		5 VAL A 143
SER A  57
SER A 131
PHE A  90
PHE A  88
 None
 1.48A 4amjA-1un1A:
undetectable		 4amjA-1un1A:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vf1 GLUTATHIONE
S-TRANSFERASE 3

(Gallus gallus) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		5 ASP A  93
VAL A  96
TRP A 155
ASN A  73
TYR A  82
 None
 0.90A 4amjA-1vf1A:
undetectable		 4amjA-1vf1A:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zc0 ALANINE GLYOXYLATE
TRANSAMINASE

(Thermococcus
litoralis) 		PF00155
(Aminotran_1_2) 		5 SER A  38
PHE A 336
ASN A 381
ASN A 186
TYR A 132
 None
None
None
PMP  A 409 (-3.7A)
PMP  A 409 (-3.7A)
 1.34A 4amjA-2zc0A:
undetectable		 4amjA-2zc0A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a5v ALPHA-GALACTOSIDASE

(Umbelopsis
vinacea) 		PF16499
(Melibiase_2) 		5 VAL A 274
SER A  37
SER A  38
TRP A  13
TYR A  19
 None
 1.29A 4amjA-3a5vA:
undetectable		 4amjA-3a5vA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3egi TRIMETHYLGUANOSINE
SYNTHASE HOMOLOG

(Homo sapiens) 		PF09445
(Methyltransf_15) 		5 VAL A 685
PHE A 761
PHE A 708
ASN A 704
TYR A 841
 None
 1.50A 4amjA-3egiA:
undetectable		 4amjA-3egiA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pbl D(3) DOPAMINE
RECEPTOR, LYSOZYME
CHIMERA

(Escherichia
virus T4;
Homo sapiens) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		5 ASP A 110
VAL A 111
SER A 192
PHE A 346
TYR A 373
 ETQ  A1200 (-3.5A)
ETQ  A1200 (-3.4A)
ETQ  A1200 (-3.3A)
ETQ  A1200 ( 4.5A)
ETQ  A1200 (-4.4A)
 1.19A 4amjA-3pblA:
32.6		 4amjA-3pblA:
29.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pbl D(3) DOPAMINE
RECEPTOR, LYSOZYME
CHIMERA

(Escherichia
virus T4;
Homo sapiens) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		8 ASP A 110
VAL A 111
SER A 192
SER A 196
TRP A 342
PHE A 345
PHE A 346
TYR A 373
 ETQ  A1200 (-3.5A)
ETQ  A1200 (-3.4A)
ETQ  A1200 (-3.3A)
ETQ  A1200 ( 4.6A)
None
ETQ  A1200 (-4.4A)
ETQ  A1200 ( 4.5A)
ETQ  A1200 (-4.4A)
 0.71A 4amjA-3pblA:
32.6		 4amjA-3pblA:
29.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pbl D(3) DOPAMINE
RECEPTOR, LYSOZYME
CHIMERA

(Escherichia
virus T4;
Homo sapiens) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		5 ASP A 110
VAL A 111
SER A 196
PHE A 345
PHE A 346
 ETQ  A1200 (-3.5A)
ETQ  A1200 (-3.4A)
ETQ  A1200 ( 4.6A)
ETQ  A1200 (-4.4A)
ETQ  A1200 ( 4.5A)
 1.47A 4amjA-3pblA:
32.6		 4amjA-3pblA:
29.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pds FUSION PROTEIN
BETA-2 ADRENERGIC
RECEPTOR/LYSOZYME

(Escherichia
virus T4;
Homo sapiens) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		7 TRP A 109
ASP A 113
VAL A 114
SER A 207
PHE A 289
ASN A 312
TYR A 316
 None
ERC  A1201 (-3.7A)
ERC  A1201 (-3.8A)
ERC  A1201 (-2.7A)
ERC  A1201 (-4.5A)
ERC  A1201 (-3.0A)
None
 1.16A 4amjA-3pdsA:
38.5		 4amjA-3pdsA:
42.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pds FUSION PROTEIN
BETA-2 ADRENERGIC
RECEPTOR/LYSOZYME

(Escherichia
virus T4;
Homo sapiens) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		11 TRP A 109
ASP A 113
VAL A 114
VAL A 117
SER A 203
SER A 207
TRP A 286
PHE A 289
PHE A 290
ASN A 293
TYR A 316
 None
ERC  A1201 (-3.7A)
ERC  A1201 (-3.8A)
None
ERC  A1201 (-2.8A)
ERC  A1201 (-2.7A)
None
ERC  A1201 (-4.5A)
ERC  A1201 (-4.8A)
ERC  A1201 (-3.5A)
None
 0.71A 4amjA-3pdsA:
38.5		 4amjA-3pdsA:
42.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pds FUSION PROTEIN
BETA-2 ADRENERGIC
RECEPTOR/LYSOZYME

(Escherichia
virus T4;
Homo sapiens) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		11 TRP A 109
ASP A 113
VAL A 114
VAL A 117
SER A 203
TRP A 286
PHE A 289
PHE A 290
ASN A 293
ASN A 312
TYR A 316
 None
ERC  A1201 (-3.7A)
ERC  A1201 (-3.8A)
None
ERC  A1201 (-2.8A)
None
ERC  A1201 (-4.5A)
ERC  A1201 (-4.8A)
ERC  A1201 (-3.5A)
ERC  A1201 (-3.0A)
None
 0.68A 4amjA-3pdsA:
38.5		 4amjA-3pdsA:
42.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pds FUSION PROTEIN
BETA-2 ADRENERGIC
RECEPTOR/LYSOZYME

(Escherichia
virus T4;
Homo sapiens) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		5 TRP A 109
ASP A 113
VAL A 117
SER A 204
TYR A 316
 None
ERC  A1201 (-3.7A)
None
ERC  A1201 ( 4.1A)
None
 1.33A 4amjA-3pdsA:
38.5		 4amjA-3pdsA:
42.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pds FUSION PROTEIN
BETA-2 ADRENERGIC
RECEPTOR/LYSOZYME

(Escherichia
virus T4;
Homo sapiens) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		5 VAL A 114
PHE A 289
ASN A 293
ASN A 312
TYR A 316
 ERC  A1201 (-3.8A)
ERC  A1201 (-4.5A)
ERC  A1201 (-3.5A)
ERC  A1201 (-3.0A)
None
 1.21A 4amjA-3pdsA:
38.5		 4amjA-3pdsA:
42.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rze HISTAMINE H1
RECEPTOR, LYSOZYME
CHIMERA

(Escherichia
virus T4;
Homo sapiens) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		5 TRP A 103
ASP A 107
TRP A 428
PHE A 432
TYR A 458
 None
5EH  A1200 ( 2.6A)
5EH  A1200 ( 3.4A)
5EH  A1200 ( 4.3A)
5EH  A1200 ( 4.4A)
 0.66A 4amjA-3rzeA:
30.7		 4amjA-3rzeA:
26.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4gbr BETA-2 ADRENERGIC
RECEPTOR

(Homo sapiens) 		PF00001
(7tm_1) 		12 TRP A 109
ASP A 113
VAL A 114
VAL A 117
SER A 203
SER A 207
TRP A 258
PHE A 261
PHE A 262
ASN A 265
ASN A 284
TYR A 288
 None
CAU  A 500 (-3.0A)
CAU  A 500 (-3.5A)
CAU  A 500 (-4.2A)
CAU  A 500 (-3.3A)
CAU  A 500 (-4.1A)
None
CAU  A 500 (-4.2A)
CAU  A 500 (-4.6A)
CAU  A 500 (-3.4A)
CAU  A 500 (-3.3A)
CAU  A 500 (-4.6A)
 0.49A 4amjA-4gbrA:
39.5		 4amjA-4gbrA:
58.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ib4 CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562

(Escherichia
coli;
Homo sapiens) 		PF00001
(7tm_1)
PF07361
(Cytochrom_B562) 		5 TRP A 131
ASP A 135
SER A 222
TRP A 337
TYR A 370
 None
ERM  A2001 (-3.2A)
ERM  A2001 ( 4.6A)
None
ERM  A2001 ( 4.8A)
 1.37A 4amjA-4ib4A:
27.8		 4amjA-4ib4A:
28.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ib4 CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562

(Escherichia
coli;
Homo sapiens) 		PF00001
(7tm_1)
PF07361
(Cytochrom_B562) 		8 TRP A 131
ASP A 135
VAL A 136
TRP A 337
PHE A 340
PHE A 341
ASN A 344
TYR A 370
 None
ERM  A2001 (-3.2A)
ERM  A2001 (-3.8A)
None
ERM  A2001 (-4.3A)
None
ERM  A2001 (-4.3A)
ERM  A2001 ( 4.8A)
 0.61A 4amjA-4ib4A:
27.8		 4amjA-4ib4A:
28.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lde LYSOZYME, BETA-2
ADRENERGIC RECEPTOR

(Escherichia
virus T4;
Homo sapiens) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		6 TRP A1109
ASP A1113
VAL A1114
SER A1203
PHE A1290
TYR A1316
 None
P0G  A1401 (-2.9A)
P0G  A1401 (-3.7A)
P0G  A1401 (-2.9A)
P0G  A1401 ( 4.9A)
None
 1.39A 4amjA-4ldeA:
33.1		 4amjA-4ldeA:
42.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lde LYSOZYME, BETA-2
ADRENERGIC RECEPTOR

(Escherichia
virus T4;
Homo sapiens) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		9 TRP A1109
ASP A1113
VAL A1114
SER A1203
TRP A1286
PHE A1289
PHE A1290
ASN A1312
TYR A1316
 None
P0G  A1401 (-2.9A)
P0G  A1401 (-3.7A)
P0G  A1401 (-2.9A)
None
P0G  A1401 ( 4.7A)
P0G  A1401 ( 4.9A)
P0G  A1401 (-2.9A)
None
 0.75A 4amjA-4ldeA:
33.1		 4amjA-4ldeA:
42.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lde LYSOZYME, BETA-2
ADRENERGIC RECEPTOR

(Escherichia
virus T4;
Homo sapiens) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		9 TRP A1109
ASP A1113
VAL A1114
TRP A1286
PHE A1289
PHE A1290
ASN A1293
ASN A1312
TYR A1316
 None
P0G  A1401 (-2.9A)
P0G  A1401 (-3.7A)
None
P0G  A1401 ( 4.7A)
P0G  A1401 ( 4.9A)
P0G  A1401 (-3.0A)
P0G  A1401 (-2.9A)
None
 0.56A 4amjA-4ldeA:
33.1		 4amjA-4ldeA:
42.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lde LYSOZYME, BETA-2
ADRENERGIC RECEPTOR

(Escherichia
virus T4;
Homo sapiens) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		8 TRP A1109
ASP A1113
VAL A1114
VAL A1117
SER A1203
SER A1207
PHE A1289
PHE A1290
 None
P0G  A1401 (-2.9A)
P0G  A1401 (-3.7A)
P0G  A1401 ( 4.4A)
P0G  A1401 (-2.9A)
P0G  A1401 (-2.8A)
P0G  A1401 ( 4.7A)
P0G  A1401 ( 4.9A)
 0.86A 4amjA-4ldeA:
33.1		 4amjA-4ldeA:
42.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lde LYSOZYME, BETA-2
ADRENERGIC RECEPTOR

(Escherichia
virus T4;
Homo sapiens) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		9 TRP A1109
ASP A1113
VAL A1114
VAL A1117
SER A1203
TRP A1286
PHE A1289
PHE A1290
ASN A1312
 None
P0G  A1401 (-2.9A)
P0G  A1401 (-3.7A)
P0G  A1401 ( 4.4A)
P0G  A1401 (-2.9A)
None
P0G  A1401 ( 4.7A)
P0G  A1401 ( 4.9A)
P0G  A1401 (-2.9A)
 0.81A 4amjA-4ldeA:
33.1		 4amjA-4ldeA:
42.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lde LYSOZYME, BETA-2
ADRENERGIC RECEPTOR

(Escherichia
virus T4;
Homo sapiens) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		8 TRP A1109
ASP A1113
VAL A1114
VAL A1117
SER A1207
PHE A1289
PHE A1290
ASN A1293
 None
P0G  A1401 (-2.9A)
P0G  A1401 (-3.7A)
P0G  A1401 ( 4.4A)
P0G  A1401 (-2.8A)
P0G  A1401 ( 4.7A)
P0G  A1401 ( 4.9A)
P0G  A1401 (-3.0A)
 0.75A 4amjA-4ldeA:
33.1		 4amjA-4ldeA:
42.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lde LYSOZYME, BETA-2
ADRENERGIC RECEPTOR

(Escherichia
virus T4;
Homo sapiens) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		9 TRP A1109
ASP A1113
VAL A1114
VAL A1117
TRP A1286
PHE A1289
PHE A1290
ASN A1293
ASN A1312
 None
P0G  A1401 (-2.9A)
P0G  A1401 (-3.7A)
P0G  A1401 ( 4.4A)
None
P0G  A1401 ( 4.7A)
P0G  A1401 ( 4.9A)
P0G  A1401 (-3.0A)
P0G  A1401 (-2.9A)
 0.64A 4amjA-4ldeA:
33.1		 4amjA-4ldeA:
42.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lde LYSOZYME, BETA-2
ADRENERGIC RECEPTOR

(Escherichia
virus T4;
Homo sapiens) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		5 VAL A1114
PHE A1289
ASN A1293
ASN A1312
TYR A1316
 P0G  A1401 (-3.7A)
P0G  A1401 ( 4.7A)
P0G  A1401 (-3.0A)
P0G  A1401 (-2.9A)
None
 1.36A 4amjA-4ldeA:
33.1		 4amjA-4ldeA:
42.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5f8u BETA-1 ADRENERGIC
RECEPTOR

(Meleagris
gallopavo) 		no annotation 8 TRP B 117
ASP B 121
VAL B 122
SER B 215
PHE B 306
PHE B 307
ASN B 329
TYR B 333
 P32  B 400 (-4.8A)
P32  B 400 (-2.2A)
P32  B 400 (-3.5A)
P32  B 400 ( 4.2A)
P32  B 400 (-4.1A)
P32  B 400 (-4.9A)
P32  B 400 (-2.9A)
P32  B 400 (-4.6A)
 1.24A 4amjA-5f8uB:
12.0		 4amjA-5f8uB:
99.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5f8u BETA-1 ADRENERGIC
RECEPTOR

(Meleagris
gallopavo) 		no annotation 12 TRP B 117
ASP B 121
VAL B 122
VAL B 125
SER B 211
SER B 215
TRP B 303
PHE B 306
PHE B 307
ASN B 310
ASN B 329
TYR B 333
 P32  B 400 (-4.8A)
P32  B 400 (-2.2A)
P32  B 400 (-3.5A)
P32  B 400 ( 4.7A)
P32  B 400 (-2.7A)
P32  B 400 ( 4.2A)
None
P32  B 400 (-4.1A)
P32  B 400 (-4.9A)
P32  B 400 (-3.5A)
P32  B 400 (-2.9A)
P32  B 400 (-4.6A)
 0.60A 4amjA-5f8uB:
12.0		 4amjA-5f8uB:
99.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gqf LACTO-N-BIOSIDASE

(Bifidobacterium
longum) 		no annotation 5 VAL A 462
VAL A 481
SER A 455
PHE A 503
ASN A 501
 None
 1.20A 4amjA-5gqfA:
undetectable		 4amjA-5gqfA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v54 5-HYDROXYTRYPTAMINE
RECEPTOR 1B,OB-1
FUSED 5-HT1B
RECEPTOR,5-HYDROXYTR
YPTAMINE RECEPTOR 1B

(Homo sapiens;
Spodoptera
frugiperda) 		no annotation 6 TRP A 125
ASP A 129
SER A 212
PHE A 330
PHE A 331
TYR A 359
 None
89F  A1201 (-3.3A)
89F  A1201 ( 3.8A)
89F  A1201 (-4.1A)
89F  A1201 (-4.6A)
None
 1.31A 4amjA-5v54A:
28.7		 4amjA-5v54A:
14.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v54 5-HYDROXYTRYPTAMINE
RECEPTOR 1B,OB-1
FUSED 5-HT1B
RECEPTOR,5-HYDROXYTR
YPTAMINE RECEPTOR 1B

(Homo sapiens;
Spodoptera
frugiperda) 		no annotation 7 TRP A 125
ASP A 129
SER A 212
TRP A 327
PHE A 330
PHE A 331
TYR A 359
 None
89F  A1201 (-3.3A)
89F  A1201 ( 3.8A)
89F  A1201 (-3.6A)
89F  A1201 (-4.1A)
89F  A1201 (-4.6A)
None
 0.80A 4amjA-5v54A:
28.7		 4amjA-5v54A:
14.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5wiv D(4) DOPAMINE
RECEPTOR, SOLUBLE
CYTOCHROME B562
CHIMERA

(Escherichia
coli;
Homo sapiens) 		no annotation 5 ASP A 115
VAL A 116
SER A 196
PHE A 411
TYR A 438
 AQD  A1201 (-3.3A)
AQD  A1201 ( 3.9A)
AQD  A1201 (-2.8A)
AQD  A1201 (-4.6A)
None
 1.20A 4amjA-5wivA:
29.7		 4amjA-5wivA:
32.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5wiv D(4) DOPAMINE
RECEPTOR, SOLUBLE
CYTOCHROME B562
CHIMERA

(Escherichia
coli;
Homo sapiens) 		no annotation 8 ASP A 115
VAL A 116
SER A 196
SER A 200
TRP A 407
PHE A 410
PHE A 411
TYR A 438
 AQD  A1201 (-3.3A)
AQD  A1201 ( 3.9A)
AQD  A1201 (-2.8A)
AQD  A1201 (-3.6A)
None
AQD  A1201 (-4.7A)
AQD  A1201 (-4.6A)
None
 0.81A 4amjA-5wivA:
29.7		 4amjA-5wivA:
32.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5wiv D(4) DOPAMINE
RECEPTOR, SOLUBLE
CYTOCHROME B562
CHIMERA

(Escherichia
coli;
Homo sapiens) 		no annotation 5 ASP A 115
VAL A 116
SER A 200
PHE A 410
PHE A 411
 AQD  A1201 (-3.3A)
AQD  A1201 ( 3.9A)
AQD  A1201 (-3.6A)
AQD  A1201 (-4.7A)
AQD  A1201 (-4.6A)
 1.50A 4amjA-5wivA:
29.7		 4amjA-5wivA:
32.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bpc MONOCLONAL ANTIBODY
4F7 FAB LIGHT CHAIN

(Mus musculus) 		no annotation 5 ASP C  41
VAL C  39
VAL C 102
SER C 194
SER C 104
 None
 1.36A 4amjA-6bpcC:
undetectable		 4amjA-6bpcC:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bqh 5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562

(Escherichia
coli;
Homo sapiens) 		no annotation 5 TRP A 130
ASP A 134
SER A 219
ASN A 331
TYR A 358
 None
E2J  A1201 (-3.0A)
E2J  A1201 (-3.2A)
None
None
 1.31A 4amjA-6bqhA:
31.4		 4amjA-6bqhA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bqh 5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562

(Escherichia
coli;
Homo sapiens) 		no annotation 5 TRP A 130
ASP A 134
SER A 219
TRP A 324
TYR A 358
 None
E2J  A1201 (-3.0A)
E2J  A1201 (-3.2A)
E2J  A1201 ( 3.7A)
None
 1.18A 4amjA-6bqhA:
31.4		 4amjA-6bqhA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bqh 5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562

(Escherichia
coli;
Homo sapiens) 		no annotation 7 TRP A 130
ASP A 134
TRP A 324
PHE A 327
PHE A 328
ASN A 331
TYR A 358
 None
E2J  A1201 (-3.0A)
E2J  A1201 ( 3.7A)
E2J  A1201 (-4.6A)
E2J  A1201 (-4.4A)
None
None
 0.61A 4amjA-6bqhA:
31.4		 4amjA-6bqhA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bqh 5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562

(Escherichia
coli;
Homo sapiens) 		no annotation 7 TRP A 130
ASP A 134
VAL A 135
TRP A 324
PHE A 327
PHE A 328
TYR A 358
 None
E2J  A1201 (-3.0A)
E2J  A1201 (-3.8A)
E2J  A1201 ( 3.7A)
E2J  A1201 (-4.6A)
E2J  A1201 (-4.4A)
None
 0.67A 4amjA-6bqhA:
31.4		 4amjA-6bqhA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cm4 D(2) DOPAMINE
RECEPTOR, ENDOLYSIN
CHIMERA

(Escherichia
virus T4;
Homo sapiens) 		no annotation 7 ASP A 114
VAL A 115
SER A 197
TRP A 386
PHE A 389
PHE A 390
TYR A 416
 8NU  A2001 ( 3.0A)
8NU  A2001 ( 3.5A)
8NU  A2001 ( 3.6A)
8NU  A2001 ( 3.8A)
8NU  A2001 ( 4.5A)
8NU  A2001 ( 4.8A)
8NU  A2001 ( 4.9A)
 0.71A 4amjA-6cm4A:
30.5		 4amjA-6cm4A:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g79 5-HYDROXYTRYPTAMINE
RECEPTOR 1B

(Homo sapiens) 		no annotation 6 TRP S 125
ASP S 129
SER S 212
PHE S 330
PHE S 331
TYR S 359
 None
EP5  S 401 (-3.3A)
EP5  S 401 (-3.3A)
EP5  S 401 (-4.0A)
EP5  S 401 (-4.7A)
EP5  S 401 ( 4.9A)
 1.17A 4amjA-6g79S:
28.2		 4amjA-6g79S:
14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g79 5-HYDROXYTRYPTAMINE
RECEPTOR 1B

(Homo sapiens) 		no annotation 7 TRP S 125
ASP S 129
SER S 212
TRP S 327
PHE S 330
PHE S 331
TYR S 359
 None
EP5  S 401 (-3.3A)
EP5  S 401 (-3.3A)
None
EP5  S 401 (-4.0A)
EP5  S 401 (-4.7A)
EP5  S 401 ( 4.9A)
 0.70A 4amjA-6g79S:
28.2		 4amjA-6g79S:
14.22