SIMILAR PATTERNS OF AMINO ACIDS FOR 4AGC_A_AXIA2000_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k9a CARBOXYL-TERMINAL
SRC KINASE

(Rattus
norvegicus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		6 VAL A 209
ALA A 220
LYS A 222
GLU A 236
GLY A 272
LEU A 321
 None
 0.54A 4agcA-1k9aA:
30.9		 4agcA-1k9aA:
29.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		7 LEU A 267
VAL A 275
ALA A 288
LYS A 290
GLU A 305
GLY A 340
LEU A 389
 P16  A   2 ( 4.2A)
P16  A   2 (-4.5A)
P16  A   2 (-3.4A)
P16  A   2 (-4.5A)
P16  A   2 (-4.2A)
P16  A   2 (-3.4A)
P16  A   2 (-4.4A)
 0.47A 4agcA-1opkA:
30.2		 4agcA-1opkA:
28.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q8y SR PROTEIN KINASE

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		6 LEU A 164
VAL A 172
ALA A 185
LYS A 187
LEU A 206
LEU A 301
 ADP  A 810 ( 4.3A)
ADP  A 810 (-4.1A)
ADP  A 810 (-3.3A)
ADP  A 810 (-3.1A)
None
ADP  A 810 (-4.7A)
 0.58A 4agcA-1q8yA:
20.6		 4agcA-1q8yA:
23.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1rjb FL CYTOKINE RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 616
VAL A 624
ALA A 642
LYS A 644
GLU A 661
GLY A 697
LEU A 818
CYH A 828
 None
 0.53A 4agcA-1rjbA:
42.2		 4agcA-1rjbA:
47.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		10 LEU A 595
VAL A 603
ALA A 621
LYS A 623
GLU A 640
LEU A 644
GLY A 676
LEU A 799
CYH A 809
PHE A 811
 STI  A   3 ( 3.8A)
STI  A   3 ( 4.6A)
STI  A   3 (-3.5A)
STI  A   3 (-3.7A)
STI  A   3 (-3.6A)
STI  A   3 (-4.4A)
STI  A   3 ( 3.8A)
STI  A   3 (-4.4A)
STI  A   3 (-4.5A)
STI  A   3 (-3.6A)
 0.48A 4agcA-1t46A:
42.9		 4agcA-1t46A:
49.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1u59 TYROSINE-PROTEIN
KINASE ZAP-70

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 344
VAL A 352
ALA A 367
GLU A 386
GLY A 420
LEU A 468
 STU  A 100 (-3.8A)
STU  A 100 (-4.8A)
STU  A 100 (-3.2A)
None
STU  A 100 (-3.5A)
STU  A 100 (-4.5A)
 0.49A 4agcA-1u59A:
31.0		 4agcA-1u59A:
30.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u5q SERINE/THREONINE
PROTEIN KINASE TAO2

(Rattus
norvegicus) 		PF00069
(Pkinase) 		6 VAL A  42
ALA A  55
GLU A  76
LEU A  80
GLY A 110
LEU A 158
 None
 0.56A 4agcA-1u5qA:
23.2		 4agcA-1u5qA:
27.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  15
VAL A  23
ALA A  36
LYS A  38
GLU A  55
GLY A  90
LEU A 137
 HYM  A 400 (-4.2A)
HYM  A 400 (-4.3A)
HYM  A 400 (-3.5A)
HYM  A 400 (-3.2A)
None
None
HYM  A 400 (-4.5A)
 0.50A 4agcA-1zltA:
20.5		 4agcA-1zltA:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a2a DEATH-ASSOCIATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  19
VAL A  27
ALA A  40
LYS A  42
GLU A  64
LEU A  68
 None
None
GOL  A3001 (-3.5A)
None
None
None
 0.53A 4agcA-2a2aA:
21.9		 4agcA-2a2aA:
25.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU X  17
VAL X  25
ALA X  37
LYS X  39
GLU X  54
GLY X  88
LEU X 137
 STU  X 902 (-3.8A)
STU  X 902 ( 4.8A)
STU  X 902 (-3.1A)
STU  X 902 (-3.1A)
STU  X 902 ( 4.4A)
STU  X 902 (-3.5A)
STU  X 902 (-4.4A)
 0.60A 4agcA-2dq7X:
30.7		 4agcA-2dq7X:
32.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eu9 DUAL SPECIFICITY
PROTEIN KINASE CLK3

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A 162
VAL A 170
ALA A 184
LYS A 186
GLU A 201
LEU A 205
 None
 0.58A 4agcA-2eu9A:
21.6		 4agcA-2eu9A:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f9g MITOGEN-ACTIVATED
PROTEIN KINASE FUS3

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		6 LEU A  19
VAL A  27
ALA A  40
LYS A  42
GLU A  59
LEU A  63
 ADP  A 500 (-4.3A)
ADP  A 500 (-4.3A)
ADP  A 500 ( 3.7A)
ADP  A 500 (-2.9A)
None
None
 0.53A 4agcA-2f9gA:
3.5		 4agcA-2f9gA:
25.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gcd SERINE/THREONINE-PRO
TEIN KINASE TAO2

(Rattus
norvegicus) 		PF00069
(Pkinase) 		6 VAL A  42
ALA A  55
GLU A  76
LEU A  80
GLY A 110
LEU A 158
 STU  A 400 ( 4.8A)
STU  A 400 (-3.2A)
None
None
STU  A 400 (-3.4A)
STU  A 400 ( 4.6A)
 0.58A 4agcA-2gcdA:
24.0		 4agcA-2gcdA:
26.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hw6 MAP
KINASE-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  55
VAL A  63
ALA A  76
GLY A 130
LEU A 177
CYH A 190
 None
 0.37A 4agcA-2hw6A:
20.3		 4agcA-2hw6A:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hw6 MAP
KINASE-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  55
VAL A  63
LYS A  78
LEU A  98
GLY A 130
LEU A 177
CYH A 190
 None
 0.62A 4agcA-2hw6A:
20.3		 4agcA-2hw6A:
24.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 248
VAL A 256
ALA A 269
LYS A 271
GLU A 286
GLY A 321
LEU A 370
PHE A 382
 GIN  A 600 ( 4.6A)
GIN  A 600 ( 4.7A)
GIN  A 600 (-3.1A)
GIN  A 600 (-3.6A)
GIN  A 600 (-3.6A)
None
GIN  A 600 (-4.7A)
GIN  A 600 (-4.0A)
 0.42A 4agcA-2hz0A:
31.6		 4agcA-2hz0A:
35.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iwi SERINE/THREONINE-PRO
TEIN KINASE PIM-2

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  38
VAL A  46
ALA A  59
GLU A  83
LEU A  87
LEU A 170
 HB1  A1289 ( 4.1A)
HB1  A1289 (-3.6A)
HB1  A1289 ( 3.7A)
None
None
HB1  A1289 (-4.7A)
 0.58A 4agcA-2iwiA:
21.0		 4agcA-2iwiA:
24.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ogv MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
PRECURSOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 588
VAL A 596
ALA A 614
GLU A 633
GLY A 669
LEU A 785
 None
 0.50A 4agcA-2ogvA:
41.0		 4agcA-2ogvA:
48.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ogv MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
PRECURSOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 588
VAL A 596
ALA A 614
LYS A 616
GLU A 633
GLY A 669
 None
 0.53A 4agcA-2ogvA:
41.0		 4agcA-2ogvA:
48.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2phk PHOSPHORYLASE KINASE

(Oryctolagus
cuniculus) 		PF00069
(Pkinase) 		6 LEU A  25
VAL A  33
ALA A  46
LEU A  77
GLY A 109
LEU A 156
 ATP  A 381 ( 4.3A)
ATP  A 381 (-4.1A)
ATP  A 381 (-3.5A)
None
None
ATP  A 381 ( 4.8A)
 0.47A 4agcA-2phkA:
21.8		 4agcA-2phkA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2phk PHOSPHORYLASE KINASE

(Oryctolagus
cuniculus) 		PF00069
(Pkinase) 		6 LEU A  25
VAL A  33
LYS A  48
LEU A  77
GLY A 109
LEU A 156
 ATP  A 381 ( 4.3A)
ATP  A 381 (-4.1A)
ATP  A 381 (-3.2A)
None
None
ATP  A 381 ( 4.8A)
 0.52A 4agcA-2phkA:
21.8		 4agcA-2phkA:
23.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 487
VAL A 495
ALA A 515
GLU A 534
VAL A 564
GLY A 570
LEU A 633
 None
 0.55A 4agcA-2psqA:
34.5		 4agcA-2psqA:
50.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 724
VAL A 732
ALA A 749
LYS A 751
GLY A 802
LEU A 850
 GW7  A   1 ( 4.2A)
GW7  A   1 ( 4.8A)
GW7  A   1 (-3.3A)
GW7  A   1 (-3.9A)
GW7  A   1 (-3.6A)
GW7  A   1 (-4.2A)
 0.58A 4agcA-2r4bA:
28.9		 4agcA-2r4bA:
35.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w4k DEATH-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  19
VAL A  27
ALA A  40
LYS A  42
GLU A  64
LEU A  68
 ADP  A1303 ( 3.9A)
ADP  A1303 (-4.0A)
ADP  A1303 (-3.5A)
ADP  A1303 (-2.7A)
ADP  A1303 ( 4.8A)
None
 0.58A 4agcA-2w4kA:
21.9		 4agcA-2w4kA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xik SERINE/THREONINE
PROTEIN KINASE 25

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  34
ALA A  47
GLU A  66
LEU A  70
GLY A 101
LEU A 147
 J60  A1294 ( 4.9A)
J60  A1294 (-3.3A)
None
None
J60  A1294 ( 3.8A)
J60  A1294 (-4.8A)
 0.55A 4agcA-2xikA:
17.8		 4agcA-2xikA:
27.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yab DEATH-ASSOCIATED
PROTEIN KINASE 2

(Mus musculus) 		PF00069
(Pkinase) 		6 LEU A  19
VAL A  27
ALA A  40
LYS A  42
GLU A  64
LEU A  68
 AMP  A1302 (-3.7A)
AMP  A1302 (-4.2A)
AMP  A1302 (-3.6A)
AMP  A1302 (-2.8A)
None
None
 0.60A 4agcA-2yabA:
21.9		 4agcA-2yabA:
25.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z7r RIBOSOMAL PROTEIN S6
KINASE ALPHA-1

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  68
VAL A  76
ALA A  92
LYS A  94
GLY A 147
LEU A 194
 STU  A   1 (-3.8A)
None
STU  A   1 (-3.3A)
STU  A   1 (-2.8A)
STU  A   1 ( 3.9A)
STU  A   1 (-4.6A)
 0.44A 4agcA-2z7rA:
21.3		 4agcA-2z7rA:
27.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 487
VAL A 495
ALA A 515
LYS A 517
VAL A 564
GLY A 570
LEU A 633
 M33  A1996 (-4.0A)
M33  A1996 ( 4.7A)
M33  A1996 (-3.3A)
M33  A1996 ( 4.5A)
None
M33  A1996 ( 4.8A)
M33  A1996 (-4.5A)
 0.46A 4agcA-3b2tA:
24.9		 4agcA-3b2tA:
49.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 484
VAL A 492
ALA A 512
GLU A 531
VAL A 561
GLY A 567
LEU A 630
 C4F  A   1 ( 3.9A)
None
C4F  A   1 (-3.3A)
None
C4F  A   1 ( 4.8A)
None
C4F  A   1 (-4.6A)
 0.59A 4agcA-3c4fA:
33.4		 4agcA-3c4fA:
54.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3d7u TYROSINE-PROTEIN
KINASE CSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 209
ALA A 220
LYS A 222
GLU A 236
GLY A 272
LEU A 321
 None
 0.54A 4agcA-3d7uA:
25.2		 4agcA-3d7uA:
32.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f2a PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  44
VAL A  52
ALA A  65
LYS A  67
GLU A  89
LEU A  93
LEU A 174
 985  A   1 (-4.1A)
985  A   1 (-4.5A)
985  A   1 (-3.5A)
985  A   1 ( 2.8A)
MG  A 314 (-3.6A)
MG  A 314 ( 4.8A)
985  A   1 (-4.8A)
 0.54A 4agcA-3f2aA:
16.3		 4agcA-3f2aA:
28.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		11 LEU A 833
VAL A 841
ALA A 859
LYS A 861
GLU A 878
LEU A 882
VAL A 909
GLY A 915
LEU A1029
CYH A1039
PHE A1041
 8ST  A2001 ( 4.7A)
8ST  A2001 ( 4.6A)
8ST  A2001 ( 3.8A)
8ST  A2001 (-4.0A)
8ST  A2001 (-3.7A)
None
8ST  A2001 (-4.1A)
None
None
8ST  A2001 (-4.2A)
8ST  A2001 ( 3.7A)
 0.51A 4agcA-3hngA:
42.0		 4agcA-3hngA:
67.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  49
VAL A  57
ALA A  70
GLU A  91
LEU A  95
GLY A 126
LEU A 173
 XFE  A 351 (-4.2A)
XFE  A 351 ( 4.5A)
XFE  A 351 (-3.2A)
None
None
None
XFE  A 351 (-4.6A)
 0.52A 4agcA-3mvjA:
20.8		 4agcA-3mvjA:
25.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  49
VAL A  57
ALA A  70
LYS A  72
GLU A  91
LEU A  95
 XFE  A 351 (-4.2A)
XFE  A 351 ( 4.5A)
XFE  A 351 (-3.2A)
None
None
None
 0.52A 4agcA-3mvjA:
20.8		 4agcA-3mvjA:
25.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nuu PKB-LIKE

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  88
VAL A  96
ALA A 109
LYS A 111
GLU A 130
GLY A 165
LEU A 212
 JOZ  A 361 (-4.1A)
JOZ  A 361 ( 4.7A)
JOZ  A 361 (-3.4A)
SO4  A   5 (-2.8A)
SO4  A   5 (-3.1A)
None
None
 0.51A 4agcA-3nuuA:
22.6		 4agcA-3nuuA:
25.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		8 LEU A 192
VAL A 200
ALA A 213
LYS A 215
GLU A 234
LEU A 238
GLY A 269
LEU A 318
 AMP  A 577 ( 4.3A)
AMP  A 577 (-4.3A)
AMP  A 577 (-3.4A)
AMP  A 577 (-2.8A)
None
None
None
AMP  A 577 (-4.8A)
 0.76A 4agcA-3nyoA:
21.1		 4agcA-3nyoA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 726
VAL A 734
ALA A 751
LYS A 753
GLY A 804
LEU A 852
 03Q  A   1 (-3.8A)
03Q  A   1 (-4.5A)
03Q  A   1 (-3.1A)
03Q  A   1 (-4.7A)
03Q  A   1 ( 3.9A)
03Q  A   1 (-4.4A)
 0.50A 4agcA-3pp0A:
29.7		 4agcA-3pp0A:
28.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q5i PROTEIN KINASE

(Plasmodium
berghei) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		7 LEU A  63
VAL A  71
ALA A  84
LYS A  86
LEU A 119
GLY A 150
LEU A 197
 ANP  A1634 ( 4.3A)
ANP  A1634 (-4.1A)
ANP  A1634 (-3.6A)
ANP  A1634 (-3.1A)
None
None
ANP  A1634 (-4.4A)
 0.55A 4agcA-3q5iA:
19.6		 4agcA-3q5iA:
22.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3tt0 BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 484
VAL A 492
ALA A 512
LYS A 514
GLU A 531
VAL A 561
GLY A 567
LEU A 630
 07J  A   1 ( 4.3A)
07J  A   1 (-4.0A)
07J  A   1 (-3.5A)
07J  A   1 (-4.5A)
07J  A   1 (-3.8A)
07J  A   1 (-4.7A)
07J  A   1 (-3.7A)
07J  A   1 ( 4.4A)
 0.60A 4agcA-3tt0A:
34.6		 4agcA-3tt0A:
50.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3txo PROTEIN KINASE C ETA
TYPE

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		7 LEU A 361
VAL A 369
ALA A 382
GLU A 403
LEU A 407
GLY A 439
LEU A 486
 07U  A   1 ( 4.8A)
07U  A   1 (-4.8A)
07U  A   1 (-3.3A)
07U  A   1 ( 4.8A)
None
None
07U  A   1 (-4.3A)
 0.68A 4agcA-3txoA:
13.1		 4agcA-3txoA:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3txo PROTEIN KINASE C ETA
TYPE

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		7 LEU A 361
VAL A 369
ALA A 382
LYS A 384
GLU A 403
LEU A 407
LEU A 486
 07U  A   1 ( 4.8A)
07U  A   1 (-4.8A)
07U  A   1 (-3.3A)
07U  A   1 (-3.0A)
07U  A   1 ( 4.8A)
None
07U  A   1 (-4.3A)
 0.65A 4agcA-3txoA:
13.1		 4agcA-3txoA:
23.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 LEU A 840
VAL A 848
ALA A 866
GLU A 885
LEU A 889
VAL A 916
GLY A 922
LEU A1035
CYH A1045
 4TT  A2001 ( 4.0A)
4TT  A2001 ( 4.5A)
4TT  A2001 (-3.5A)
None
None
None
4TT  A2001 (-3.7A)
4TT  A2001 (-4.8A)
None
 0.44A 4agcA-3vidA:
30.0		 4agcA-3vidA:
85.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 840
VAL A 848
ALA A 866
LYS A 868
GLU A 885
LEU A 889
VAL A 916
 4TT  A2001 ( 4.0A)
4TT  A2001 ( 4.5A)
4TT  A2001 (-3.5A)
None
None
None
None
 0.56A 4agcA-3vidA:
30.0		 4agcA-3vidA:
85.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 LEU A 840
VAL A 848
ALA A 866
GLU A 885
LEU A 889
VAL A 916
GLY A 922
LEU A1035
CYH A1045
 LEV  A1201 ( 3.8A)
LEV  A1201 ( 4.9A)
LEV  A1201 (-3.5A)
LEV  A1201 (-3.7A)
LEV  A1201 ( 4.4A)
LEV  A1201 ( 4.6A)
LEV  A1201 (-3.6A)
LEV  A1201 (-4.8A)
GOL  A1210 ( 3.3A)
 0.46A 4agcA-3wzdA:
38.3		 4agcA-3wzdA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		10 ILE A 804
LEU A 840
VAL A 848
ALA A 866
GLU A 885
VAL A 916
GLY A 922
LEU A1035
CYH A1045
PHE A1047
 None
B49  A2000 (-3.7A)
None
B49  A2000 (-3.5A)
None
B49  A2000 (-4.8A)
B49  A2000 ( 3.7A)
B49  A2000 (-4.5A)
B49  A2000 ( 4.1A)
B49  A2000 (-4.0A)
 0.42A 4agcA-4agdA:
48.6		 4agcA-4agdA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		10 ILE A 804
LEU A 840
VAL A 848
ALA A 866
LYS A 868
GLU A 885
GLY A 922
LEU A1035
CYH A1045
PHE A1047
 None
B49  A2000 (-3.7A)
None
B49  A2000 (-3.5A)
B49  A2000 (-3.0A)
None
B49  A2000 ( 3.7A)
B49  A2000 (-4.5A)
B49  A2000 ( 4.1A)
B49  A2000 (-4.0A)
 0.52A 4agcA-4agdA:
48.6		 4agcA-4agdA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		10 LEU A 840
VAL A 848
ALA A 866
GLU A 885
LEU A 889
VAL A 916
GLY A 922
LEU A1035
CYH A1045
PHE A1047
 B49  A2000 (-3.7A)
None
B49  A2000 (-3.5A)
None
None
B49  A2000 (-4.8A)
B49  A2000 ( 3.7A)
B49  A2000 (-4.5A)
B49  A2000 ( 4.1A)
B49  A2000 (-4.0A)
 0.45A 4agcA-4agdA:
48.6		 4agcA-4agdA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		10 LEU A 840
VAL A 848
ALA A 866
LYS A 868
GLU A 885
LEU A 889
GLY A 922
LEU A1035
CYH A1045
PHE A1047
 B49  A2000 (-3.7A)
None
B49  A2000 (-3.5A)
B49  A2000 (-3.0A)
None
None
B49  A2000 ( 3.7A)
B49  A2000 (-4.5A)
B49  A2000 ( 4.1A)
B49  A2000 (-4.0A)
 0.56A 4agcA-4agdA:
48.6		 4agcA-4agdA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4agu CYCLIN-DEPENDENT
KINASE-LIKE 1

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A  18
ALA A  31
LYS A  33
GLU A  51
LEU A  55
LEU A 133
CYH A 143
 D15  A 500 (-4.6A)
D15  A 500 (-3.4A)
D15  A 500 ( 4.1A)
None
None
D15  A 500 (-4.5A)
D15  A 500 ( 4.0A)
 0.60A 4agcA-4aguA:
22.2		 4agcA-4aguA:
25.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aw2 SERINE/THREONINE-PRO
TEIN KINASE MRCK
ALPHA

(Rattus
norvegicus) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		7 VAL A  91
ALA A 104
LYS A 106
GLU A 125
LEU A 129
GLY A 160
LEU A 208
 None
EDO  A1420 (-3.4A)
EDO  A1419 (-3.3A)
EDO  A1419 (-3.0A)
None
None
EDO  A1420 ( 4.8A)
 0.68A 4agcA-4aw2A:
19.3		 4agcA-4aw2A:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c0t LIKELY PROTEIN
KINASE

(Candida
albicans) 		PF00069
(Pkinase) 		7 LEU A 246
VAL A 254
ALA A 267
GLU A 288
LEU A 292
GLY A 324
LEU A 371
 None
 0.75A 4agcA-4c0tA:
22.0		 4agcA-4c0tA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c0t LIKELY PROTEIN
KINASE

(Candida
albicans) 		PF00069
(Pkinase) 		7 LEU A 246
VAL A 254
ALA A 267
LYS A 269
LEU A 292
GLY A 324
LEU A 371
 None
 0.60A 4agcA-4c0tA:
22.0		 4agcA-4c0tA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4crs SERINE/THREONINE-PRO
TEIN KINASE N2

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		6 LEU A 663
VAL A 671
ALA A 684
LYS A 686
GLY A 743
LEU A 789
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
AGS  A1985 (-3.0A)
None
AGS  A1985 (-4.8A)
 0.52A 4agcA-4crsA:
15.2		 4agcA-4crsA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eut SERINE/THREONINE-PRO
TEIN KINASE TBK1

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  15
VAL A  23
ALA A  36
LYS A  38
GLU A  55
LEU A  59
GLY A  92
 BX7  A 401 (-3.7A)
BX7  A 401 (-4.4A)
BX7  A 401 (-3.4A)
BX7  A 401 ( 4.0A)
None
None
BX7  A 401 (-3.5A)
 0.51A 4agcA-4eutA:
19.3		 4agcA-4eutA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4euu SERINE/THREONINE-PRO
TEIN KINASE TBK1

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  15
VAL A  23
ALA A  36
LYS A  38
GLU A  55
LEU A  59
GLY A  92
 BX7  A 401 (-3.9A)
BX7  A 401 ( 4.6A)
BX7  A 401 (-3.4A)
BX7  A 401 (-3.5A)
None
None
BX7  A 401 (-3.3A)
 0.43A 4agcA-4euuA:
21.6		 4agcA-4euuA:
24.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4f4p TYROSINE-PROTEIN
KINASE SYK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 377
VAL A 385
ALA A 400
LYS A 402
GLU A 420
GLY A 454
LEU A 501
 0SB  A 701 ( 3.9A)
0SB  A 701 (-4.0A)
0SB  A 701 (-3.3A)
0SB  A 701 ( 4.8A)
None
0SB  A 701 (-3.5A)
0SB  A 701 (-4.4A)
 0.89A 4agcA-4f4pA:
30.0		 4agcA-4f4pA:
34.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f99 CELL DIVISION CYCLE
7-RELATED PROTEIN
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  72
ALA A  88
LYS A  90
GLU A 104
LEU A 108
LEU A 184
 ADP  A 601 (-4.0A)
ADP  A 601 (-3.5A)
ADP  A 601 (-2.6A)
None
None
ADP  A 601 ( 4.9A)
 0.55A 4agcA-4f99A:
13.7		 4agcA-4f99A:
22.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4fod ALK TYROSINE KINASE
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A1122
VAL A1130
ALA A1148
LYS A1150
GLU A1167
GLY A1202
LEU A1256
 0UV  A1501 (-3.8A)
0UV  A1501 (-4.5A)
0UV  A1501 (-3.4A)
0UV  A1501 (-3.7A)
None
0UV  A1501 (-3.6A)
0UV  A1501 (-4.6A)
 0.88A 4agcA-4fodA:
24.4		 4agcA-4fodA:
33.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g3f NF-KAPPA-BETA-INDUCI
NG KINASE

(Mus musculus) 		PF00069
(Pkinase) 		6 VAL A 416
ALA A 429
GLU A 442
GLY A 477
LEU A 524
CYH A 535
 0WB  A 701 (-4.4A)
0WB  A 701 (-3.3A)
0WB  A 701 (-3.2A)
0WB  A 701 ( 4.5A)
0WB  A 701 (-4.3A)
0WB  A 701 ( 3.7A)
 0.53A 4agcA-4g3fA:
21.3		 4agcA-4g3fA:
25.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gv1 RAC-ALPHA
SERINE/THREONINE-PRO
TEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		7 LEU A 156
VAL A 164
ALA A 177
LYS A 179
GLU A 198
LEU A 202
GLY A 233
 0XZ  A 501 ( 4.1A)
0XZ  A 501 (-4.5A)
0XZ  A 501 (-3.3A)
GOL  A 503 ( 2.8A)
GOL  A 503 (-3.6A)
None
None
 0.67A 4agcA-4gv1A:
20.6		 4agcA-4gv1A:
23.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hvi TYROSINE-PROTEIN
KINASE JAK3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 828
VAL A 836
ALA A 853
LYS A 855
GLU A 871
GLY A 908
LEU A 956
 19S  A1201 (-3.9A)
19S  A1201 (-4.4A)
19S  A1201 (-3.3A)
19S  A1201 (-3.5A)
None
19S  A1201 ( 3.8A)
19S  A1201 (-4.5A)
 0.44A 4agcA-4hviA:
29.8		 4agcA-4hviA:
31.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hzs ACTIVATED CDC42
KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14604
(SH3_9) 		6 LEU A 132
VAL A 140
ALA A 156
LYS A 158
GLY A 211
LEU A 259
 None
 0.43A 4agcA-4hzsA:
27.0		 4agcA-4hzsA:
30.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4id7 ACTIVATED CDC42
KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 132
VAL A 140
ALA A 156
LYS A 158
GLY A 211
LEU A 259
 1G0  A 401 ( 4.5A)
1G0  A 401 (-4.4A)
1G0  A 401 (-3.6A)
1G0  A 401 (-3.7A)
1G0  A 401 ( 4.5A)
1G0  A 401 (-4.6A)
 0.47A 4agcA-4id7A:
29.4		 4agcA-4id7A:
33.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4idt MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 14

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A 406
VAL A 414
LYS A 429
GLU A 440
GLY A 475
LEU A 522
CYH A 533
 T28  A 701 (-3.8A)
T28  A 701 (-4.7A)
T28  A 701 ( 3.8A)
None
T28  A 701 ( 3.0A)
T28  A 701 (-3.9A)
T28  A 701 (-3.7A)
 0.74A 4agcA-4idtA:
21.5		 4agcA-4idtA:
26.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jxf SERINE/THREONINE-PRO
TEIN KINASE PLK4

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  18
VAL A  26
ALA A  39
LYS A  41
GLY A  95
LEU A 143
 631  A 301 (-3.4A)
631  A 301 (-4.6A)
631  A 301 (-3.3A)
631  A 301 (-2.7A)
631  A 301 ( 3.7A)
631  A 301 (-4.0A)
 0.53A 4agcA-4jxfA:
8.5		 4agcA-4jxfA:
23.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4k33 FIBROBLAST GROWTH
FACTOR RECEPTOR 3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 478
VAL A 486
ALA A 506
LYS A 508
GLU A 525
VAL A 555
GLY A 561
LEU A 624
 ACP  A 801 (-3.8A)
ACP  A 801 (-4.2A)
ACP  A 801 (-3.3A)
ACP  A 801 (-2.7A)
ACP  A 801 ( 4.8A)
ACP  A 801 (-4.7A)
ACP  A 801 ( 4.6A)
ACP  A 801 (-4.4A)
 0.63A 4agcA-4k33A:
25.9		 4agcA-4k33A:
51.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l52 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 7,
TGF-BETA-ACTIVATED
KINASE 1 AND
MAP3K7-BINDING
PROTEIN 1 CHIMERA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A  50
ALA A  61
GLU A  77
LEU A  81
GLY A 110
LEU A 163
CYH A 174
 1UL  A 501 ( 4.9A)
1UL  A 501 (-3.1A)
None
None
1UL  A 501 ( 3.7A)
1UL  A 501 (-4.3A)
1UL  A 501 (-3.6A)
 0.62A 4agcA-4l52A:
19.2		 4agcA-4l52A:
28.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o27 SERINE/THREONINE-PRO
TEIN KINASE 24

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL B  38
ALA B  51
LYS B  53
GLU B  70
LEU B  74
GLY B 105
LEU B 151
 ADP  B 500 (-4.5A)
ADP  B 500 (-3.3A)
ADP  B 500 (-3.1A)
None
None
None
ADP  B 500 (-4.7A)
 0.75A 4agcA-4o27B:
17.1		 4agcA-4o27B:
25.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o38 CYCLIN-G-ASSOCIATED
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		8 LEU A  46
VAL A  54
ALA A  67
LYS A  69
GLU A  85
GLY A 128
LEU A 180
CYH A 190
 SIN  A 401 ( 3.9A)
None
SIN  A 401 ( 3.7A)
None
None
SIN  A 401 (-3.5A)
SIN  A 401 ( 4.5A)
None
 0.68A 4agcA-4o38A:
20.0		 4agcA-4o38A:
24.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 903
VAL A 911
ALA A 928
GLU A 947
GLY A 984
LEU A1030
 2TT  A1202 (-3.5A)
2TT  A1202 (-4.5A)
2TT  A1202 ( 3.9A)
None
2TT  A1202 (-3.4A)
2TT  A1202 (-4.4A)
 0.45A 4agcA-4oliA:
27.5		 4agcA-4oliA:
24.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4otd SERINE/THREONINE-PRO
TEIN KINASE N1

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		6 LEU A 627
VAL A 635
ALA A 648
LEU A 673
GLY A 707
LEU A 753
 None
 0.53A 4agcA-4otdA:
21.2		 4agcA-4otdA:
26.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q9z HUMAN PROTEIN KINASE
C THETA

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		6 LEU A 386
VAL A 394
ALA A 407
LYS A 409
LEU A 432
LEU A 511
 PZW  A 801 (-3.9A)
PZW  A 801 (-4.6A)
PZW  A 801 (-3.5A)
None
None
PZW  A 801 (-4.8A)
 0.57A 4agcA-4q9zA:
19.6		 4agcA-4q9zA:
24.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 LEU A 616
VAL A 624
ALA A 642
LYS A 644
GLU A 661
GLY A 697
LEU A 818
CYH A 828
PHE A 830
 P30  A1001 (-3.8A)
None
P30  A1001 (-3.4A)
P30  A1001 (-3.4A)
P30  A1001 (-3.6A)
P30  A1001 (-3.4A)
P30  A1001 (-4.6A)
P30  A1001 (-4.1A)
P30  A1001 (-3.9A)
 0.30A 4agcA-4rt7A:
31.3		 4agcA-4rt7A:
43.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wb7 DNAJ HOMOLOG
SUBFAMILY B MEMBER
1,CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA

(Homo sapiens) 		PF00069
(Pkinase)
PF00226
(DnaJ) 		7 LEU A 104
VAL A 112
ALA A 125
LYS A 127
GLU A 146
GLY A 181
LEU A 228
 ATP  A 501 ( 4.3A)
ATP  A 501 (-4.0A)
ATP  A 501 (-3.4A)
ATP  A 501 (-2.6A)
None
None
ATP  A 501 (-4.5A)
 0.56A 4agcA-4wb7A:
20.6		 4agcA-4wb7A:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wb7 DNAJ HOMOLOG
SUBFAMILY B MEMBER
1,CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA

(Homo sapiens) 		PF00069
(Pkinase)
PF00226
(DnaJ) 		7 LEU A 104
VAL A 112
ALA A 125
LYS A 127
LEU A 150
GLY A 181
LEU A 228
 ATP  A 501 ( 4.3A)
ATP  A 501 (-4.0A)
ATP  A 501 (-3.4A)
ATP  A 501 (-2.6A)
None
None
ATP  A 501 (-4.5A)
 0.60A 4agcA-4wb7A:
20.6		 4agcA-4wb7A:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wbo RHODOPSIN KINASE

(Bos taurus) 		PF00069
(Pkinase)
PF00615
(RGS) 		7 LEU A 193
VAL A 201
ALA A 214
LYS A 216
LEU A 239
GLY A 270
LEU A 321
 ANW  A 601 ( 4.0A)
None
ANW  A 601 (-3.4A)
None
None
ANW  A 601 ( 4.5A)
ANW  A 601 (-4.9A)
 0.62A 4agcA-4wboA:
22.0		 4agcA-4wboA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wsq AP2-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  52
VAL A  60
ALA A  72
GLY A 132
LEU A 183
CYH A 193
 KSA  A 405 ( 4.0A)
KSA  A 405 ( 4.9A)
KSA  A 405 (-3.2A)
KSA  A 405 (-3.5A)
KSA  A 405 (-4.6A)
KSA  A 405 (-3.4A)
 0.36A 4agcA-4wsqA:
22.5		 4agcA-4wsqA:
24.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xcu FIBROBLAST GROWTH
FACTOR RECEPTOR 4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 473
VAL A 481
ALA A 501
LYS A 503
GLU A 520
VAL A 550
 40M  A1002 ( 4.6A)
40M  A1002 ( 4.5A)
40M  A1002 ( 4.1A)
40M  A1002 (-4.0A)
40M  A1002 (-3.7A)
40M  A1002 (-4.7A)
 0.59A 4agcA-4xcuA:
33.7		 4agcA-4xcuA:
47.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 616
VAL A 624
ALA A 642
GLU A 661
GLY A 697
LEU A 818
CYH A 828
PHE A 830
 P30  A1001 (-4.0A)
P30  A1001 ( 4.8A)
P30  A1001 (-3.5A)
P30  A1001 (-3.1A)
P30  A1001 (-3.5A)
P30  A1001 (-4.3A)
P30  A1001 (-4.8A)
P30  A1001 ( 4.1A)
 0.59A 4agcA-4xufA:
39.1		 4agcA-4xufA:
51.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 616
VAL A 624
ALA A 642
LYS A 644
GLU A 661
GLY A 697
LEU A 818
PHE A 830
 P30  A1001 (-4.0A)
P30  A1001 ( 4.8A)
P30  A1001 (-3.5A)
P30  A1001 ( 4.0A)
P30  A1001 (-3.1A)
P30  A1001 (-3.5A)
P30  A1001 (-4.3A)
P30  A1001 ( 4.1A)
 0.72A 4agcA-4xufA:
39.1		 4agcA-4xufA:
51.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE

(Eimeria tenella) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		8 LEU A  34
VAL A  42
ALA A  55
LYS A  57
GLU A  76
LEU A  80
GLY A 111
LEU A 158
 ADP  A 506 ( 3.8A)
ADP  A 506 (-4.3A)
ADP  A 506 (-3.3A)
ADP  A 506 (-2.4A)
None
None
None
ADP  A 506 (-4.7A)
 0.53A 4agcA-4ysjA:
21.9		 4agcA-4ysjA:
23.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 484
VAL A 492
ALA A 512
LYS A 514
GLU A 531
VAL A 561
GLY A 567
LEU A 630
 38O  A1769 (-3.2A)
38O  A1769 (-4.5A)
38O  A1769 (-3.6A)
38O  A1769 ( 3.1A)
EDO  A1766 (-4.1A)
38O  A1769 (-4.3A)
38O  A1769 (-3.4A)
38O  A1769 (-4.6A)
 0.60A 4agcA-5a46A:
34.6		 4agcA-5a46A:
45.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e8y TGF-BETA RECEPTOR
TYPE-2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 258
ALA A 275
LYS A 277
GLY A 331
LEU A 386
CYH A 396
 STU  A 601 (-4.0A)
STU  A 601 (-3.1A)
STU  A 601 (-2.4A)
STU  A 601 (-3.5A)
STU  A 601 (-3.9A)
STU  A 601 (-3.2A)
 0.46A 4agcA-5e8yA:
24.3		 4agcA-5e8yA:
27.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eyk AURORA KINASE B-A

(Xenopus laevis) 		PF00069
(Pkinase) 		6 LEU A  99
VAL A 107
ALA A 120
LYS A 122
GLY A 176
LEU A 223
 5U5  A 401 (-3.8A)
5U5  A 401 ( 4.3A)
5U5  A 401 (-3.5A)
5U5  A 401 (-2.6A)
5U5  A 401 (-3.4A)
5U5  A 401 (-4.7A)
 0.36A 4agcA-5eykA:
22.1		 4agcA-5eykA:
25.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 903
VAL A 911
ALA A 928
LYS A 930
GLU A 947
GLY A 984
LEU A1030
 5U3  A1200 (-3.8A)
5U3  A1200 ( 4.4A)
5U3  A1200 (-3.5A)
None
None
5U3  A1200 (-3.2A)
5U3  A1200 (-4.4A)
 0.53A 4agcA-5f1zA:
28.2		 4agcA-5f1zA:
28.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 730
VAL A 738
ALA A 756
LYS A 758
GLU A 775
LEU A 779
VAL A 804
 PP1  A2012 (-4.6A)
PP1  A2012 (-4.4A)
PP1  A2012 (-3.2A)
PP1  A2012 (-4.1A)
PP1  A2012 (-3.5A)
None
PP1  A2012 (-4.5A)
 0.64A 4agcA-5fm2A:
32.4		 4agcA-5fm2A:
41.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 730
VAL A 738
ALA A 756
LYS A 758
LEU A 779
VAL A 804
GLY A 810
 PP1  A2012 (-4.6A)
PP1  A2012 (-4.4A)
PP1  A2012 (-3.2A)
PP1  A2012 (-4.1A)
None
PP1  A2012 (-4.5A)
PTR  A 809 (-2.4A)
 0.65A 4agcA-5fm2A:
32.4		 4agcA-5fm2A:
41.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 730
VAL A 738
ALA A 756
LYS A 758
VAL A 804
GLY A 810
LEU A 881
 PP1  A2012 (-4.6A)
PP1  A2012 (-4.4A)
PP1  A2012 (-3.2A)
PP1  A2012 (-4.1A)
PP1  A2012 (-4.5A)
PTR  A 809 (-2.4A)
PP1  A2012 (-4.6A)
 0.61A 4agcA-5fm2A:
32.4		 4agcA-5fm2A:
41.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 LEU A 599
VAL A 607
ALA A 625
LYS A 627
GLU A 644
GLY A 680
LEU A 825
CYH A 835
PHE A 837
 748  A1001 (-3.8A)
748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 (-4.0A)
748  A1001 (-3.3A)
748  A1001 ( 4.0A)
748  A1001 (-4.3A)
748  A1001 (-4.5A)
748  A1001 (-3.7A)
 0.45A 4agcA-5grnA:
32.3		 4agcA-5grnA:
48.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN

(Drosophila
melanogaster) 		PF00069
(Pkinase) 		7 LEU A  20
VAL A  28
ALA A  41
LYS A  43
GLU A  61
GLY A  96
LEU A 143
 ADP  A 301 ( 4.0A)
ADP  A 301 (-3.7A)
ADP  A 301 (-3.5A)
ADP  A 301 (-2.7A)
None
None
ADP  A 301 (-4.7A)
 0.63A 4agcA-5hu3A:
22.3		 4agcA-5hu3A:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i3o BMP-2-INDUCIBLE
PROTEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  57
VAL A  65
ALA A  77
GLY A 136
LEU A 187
CYH A 197
 IDV  A 401 (-3.8A)
IDV  A 401 (-4.6A)
IDV  A 401 (-3.6A)
IDV  A 401 (-3.4A)
IDV  A 401 (-4.4A)
IDV  A 401 (-3.6A)
 0.44A 4agcA-5i3oA:
22.3		 4agcA-5i3oA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  30
ALA A  43
LYS A  45
GLU A  61
GLY A  96
LEU A 143
 6G2  A 901 ( 4.9A)
6G2  A 901 (-3.2A)
6G2  A 901 ( 3.9A)
None
6G2  A 901 (-3.6A)
6G2  A 901 (-4.7A)
 0.59A 4agcA-5j5tA:
20.5		 4agcA-5j5tA:
21.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5j9z EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 718
VAL A 726
ALA A 743
LYS A 745
GLY A 796
LEU A 844
 6HJ  A1101 ( 4.6A)
6HJ  A1101 ( 4.7A)
6HJ  A1101 (-3.1A)
6HJ  A1101 (-4.2A)
6HJ  A1101 ( 4.5A)
6HJ  A1101 ( 4.8A)
 0.53A 4agcA-5j9zA:
30.6		 4agcA-5j9zA:
31.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tur SERINE/THREONINE-PRO
TEIN KINASE PIM-1

(Homo sapiens) 		no annotation 7 LEU A  44
VAL A  52
ALA A  65
LYS A  67
GLU A  89
LEU A  93
LEU A 174
 None
7LK  A 401 (-4.9A)
7LK  A 401 (-3.3A)
None
None
None
7LK  A 401 (-4.8A)
 0.52A 4agcA-5turA:
21.1		 4agcA-5turA:
26.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vil MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 5

(Homo sapiens) 		no annotation 7 LEU A 686
VAL A 694
ALA A 707
LYS A 709
GLU A 725
GLY A 760
LEU A 810
 9E1  A1001 (-3.7A)
9E1  A1001 ( 4.0A)
9E1  A1001 (-3.5A)
9E1  A1001 (-2.8A)
None
9E1  A1001 (-3.4A)
9E1  A1001 (-4.5A)
 0.43A 4agcA-5vilA:
18.0		 4agcA-5vilA:
12.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c7y TYROSINE-PROTEIN
KINASE JAK1

(Homo sapiens) 		no annotation 7 LEU A 881
VAL A 889
ALA A 906
LYS A 908
GLU A 925
GLY A 962
LEU A1010
 ADP  A1201 ( 4.5A)
ADP  A1201 (-4.3A)
ADP  A1201 (-3.4A)
ADP  A1201 (-2.8A)
None
ADP  A1201 ( 4.1A)
ADP  A1201 (-4.5A)
 0.58A 4agcA-6c7yA:
27.7		 4agcA-6c7yA:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fek PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET

(Homo sapiens) 		no annotation 6 LEU A 730
VAL A 738
ALA A 756
GLU A 775
LEU A 779
VAL A 804
 ADN  A1104 ( 4.0A)
ADN  A1104 (-4.4A)
ADN  A1104 (-3.4A)
None
None
ADN  A1104 ( 4.6A)
 0.50A 4agcA-6fekA:
31.9		 4agcA-6fekA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fek PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET

(Homo sapiens) 		no annotation 7 LEU A 730
VAL A 738
ALA A 756
LEU A 779
VAL A 804
GLY A 810
LEU A 881
 ADN  A1104 ( 4.0A)
ADN  A1104 (-4.4A)
ADN  A1104 (-3.4A)
None
ADN  A1104 ( 4.6A)
ADN  A1104 ( 3.8A)
ADN  A1104 (-4.3A)
 0.58A 4agcA-6fekA:
31.9		 4agcA-6fekA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyl DUAL SPECIFICITY
PROTEIN KINASE CLK2

(Homo sapiens) 		no annotation 7 LEU A 169
VAL A 177
ALA A 191
LYS A 193
LEU A 212
GLY A 247
LEU A 297
 3NG  A 501 (-3.9A)
3NG  A 501 ( 4.4A)
3NG  A 501 (-3.3A)
3NG  A 501 (-3.0A)
None
None
None
 1.04A 4agcA-6fylA:
21.7		 4agcA-6fylA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4

(Homo sapiens) 		no annotation 8 LEU A 167
VAL A 175
ALA A 189
LYS A 191
GLU A 206
LEU A 210
GLY A 245
LEU A 295
 3NG  A 501 (-3.9A)
3NG  A 501 ( 4.3A)
3NG  A 501 (-3.5A)
3NG  A 501 (-2.7A)
3NG  A 501 ( 4.7A)
None
None
None
 1.15A 4agcA-6fyvA:
21.4		 4agcA-6fyvA:
undetectable