SIMILAR PATTERNS OF AMINO ACIDS FOR 4AGC_A_AXIA2000
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1k9a | CARBOXYL-TERMINALSRC KINASE (Rattusnorvegicus) |
PF00017(SH2)PF00018(SH3_1)PF07714(Pkinase_Tyr) | 6 | VAL A 209ALA A 220LYS A 222GLU A 236GLY A 272LEU A 321 | None | 0.54A | 4agcA-1k9aA:30.9 | 4agcA-1k9aA:29.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1opk | PROTO-ONCOGENETYROSINE-PROTEINKINASE ABL1 (Mus musculus) |
PF00017(SH2)PF00018(SH3_1)PF07714(Pkinase_Tyr) | 7 | LEU A 267VAL A 275ALA A 288LYS A 290GLU A 305GLY A 340LEU A 389 | P16 A 2 ( 4.2A)P16 A 2 (-4.5A)P16 A 2 (-3.4A)P16 A 2 (-4.5A)P16 A 2 (-4.2A)P16 A 2 (-3.4A)P16 A 2 (-4.4A) | 0.47A | 4agcA-1opkA:30.2 | 4agcA-1opkA:28.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1q8y | SR PROTEIN KINASE (Saccharomycescerevisiae) |
PF00069(Pkinase) | 6 | LEU A 164VAL A 172ALA A 185LYS A 187LEU A 206LEU A 301 | ADP A 810 ( 4.3A)ADP A 810 (-4.1A)ADP A 810 (-3.3A)ADP A 810 (-3.1A)NoneADP A 810 (-4.7A) | 0.58A | 4agcA-1q8yA:20.6 | 4agcA-1q8yA:23.45 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1rjb | FL CYTOKINE RECEPTOR (Homo sapiens) |
PF07714(Pkinase_Tyr) | 8 | LEU A 616VAL A 624ALA A 642LYS A 644GLU A 661GLY A 697LEU A 818CYH A 828 | None | 0.53A | 4agcA-1rjbA:42.2 | 4agcA-1rjbA:47.80 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homo sapiens) |
PF07714(Pkinase_Tyr) | 10 | LEU A 595VAL A 603ALA A 621LYS A 623GLU A 640LEU A 644GLY A 676LEU A 799CYH A 809PHE A 811 | STI A 3 ( 3.8A)STI A 3 ( 4.6A)STI A 3 (-3.5A)STI A 3 (-3.7A)STI A 3 (-3.6A)STI A 3 (-4.4A)STI A 3 ( 3.8A)STI A 3 (-4.4A)STI A 3 (-4.5A)STI A 3 (-3.6A) | 0.48A | 4agcA-1t46A:42.9 | 4agcA-1t46A:49.44 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1u59 | TYROSINE-PROTEINKINASE ZAP-70 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 6 | LEU A 344VAL A 352ALA A 367GLU A 386GLY A 420LEU A 468 | STU A 100 (-3.8A)STU A 100 (-4.8A)STU A 100 (-3.2A)NoneSTU A 100 (-3.5A)STU A 100 (-4.5A) | 0.49A | 4agcA-1u59A:31.0 | 4agcA-1u59A:30.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1u5q | SERINE/THREONINEPROTEIN KINASE TAO2 (Rattusnorvegicus) |
PF00069(Pkinase) | 6 | VAL A 42ALA A 55GLU A 76LEU A 80GLY A 110LEU A 158 | None | 0.56A | 4agcA-1u5qA:23.2 | 4agcA-1u5qA:27.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zlt | SERINE/THREONINE-PROTEIN KINASE CHK1 (Homo sapiens) |
PF00069(Pkinase) | 7 | LEU A 15VAL A 23ALA A 36LYS A 38GLU A 55GLY A 90LEU A 137 | HYM A 400 (-4.2A)HYM A 400 (-4.3A)HYM A 400 (-3.5A)HYM A 400 (-3.2A)NoneNoneHYM A 400 (-4.5A) | 0.50A | 4agcA-1zltA:20.5 | 4agcA-1zltA:23.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2a2a | DEATH-ASSOCIATEDPROTEIN KINASE 2 (Homo sapiens) |
PF00069(Pkinase) | 6 | LEU A 19VAL A 27ALA A 40LYS A 42GLU A 64LEU A 68 | NoneNoneGOL A3001 (-3.5A)NoneNoneNone | 0.53A | 4agcA-2a2aA:21.9 | 4agcA-2a2aA:25.96 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2dq7 | PROTO-ONCOGENETYROSINE-PROTEINKINASE FYN (Homo sapiens) |
PF07714(Pkinase_Tyr) | 7 | LEU X 17VAL X 25ALA X 37LYS X 39GLU X 54GLY X 88LEU X 137 | STU X 902 (-3.8A)STU X 902 ( 4.8A)STU X 902 (-3.1A)STU X 902 (-3.1A)STU X 902 ( 4.4A)STU X 902 (-3.5A)STU X 902 (-4.4A) | 0.60A | 4agcA-2dq7X:30.7 | 4agcA-2dq7X:32.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2eu9 | DUAL SPECIFICITYPROTEIN KINASE CLK3 (Homo sapiens) |
PF00069(Pkinase) | 6 | LEU A 162VAL A 170ALA A 184LYS A 186GLU A 201LEU A 205 | None | 0.58A | 4agcA-2eu9A:21.6 | 4agcA-2eu9A:22.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2f9g | MITOGEN-ACTIVATEDPROTEIN KINASE FUS3 (Saccharomycescerevisiae) |
PF00069(Pkinase) | 6 | LEU A 19VAL A 27ALA A 40LYS A 42GLU A 59LEU A 63 | ADP A 500 (-4.3A)ADP A 500 (-4.3A)ADP A 500 ( 3.7A)ADP A 500 (-2.9A)NoneNone | 0.53A | 4agcA-2f9gA:3.5 | 4agcA-2f9gA:25.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gcd | SERINE/THREONINE-PROTEIN KINASE TAO2 (Rattusnorvegicus) |
PF00069(Pkinase) | 6 | VAL A 42ALA A 55GLU A 76LEU A 80GLY A 110LEU A 158 | STU A 400 ( 4.8A)STU A 400 (-3.2A)NoneNoneSTU A 400 (-3.4A)STU A 400 ( 4.6A) | 0.58A | 4agcA-2gcdA:24.0 | 4agcA-2gcdA:26.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hw6 | MAPKINASE-INTERACTINGSERINE/THREONINE-PROTEIN KINASE 1 (Homo sapiens) |
PF00069(Pkinase) | 6 | LEU A 55VAL A 63ALA A 76GLY A 130LEU A 177CYH A 190 | None | 0.37A | 4agcA-2hw6A:20.3 | 4agcA-2hw6A:24.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hw6 | MAPKINASE-INTERACTINGSERINE/THREONINE-PROTEIN KINASE 1 (Homo sapiens) |
PF00069(Pkinase) | 7 | LEU A 55VAL A 63LYS A 78LEU A 98GLY A 130LEU A 177CYH A 190 | None | 0.62A | 4agcA-2hw6A:20.3 | 4agcA-2hw6A:24.94 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2hz0 | PROTO-ONCOGENETYROSINE-PROTEINKINASE ABL1 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 8 | LEU A 248VAL A 256ALA A 269LYS A 271GLU A 286GLY A 321LEU A 370PHE A 382 | GIN A 600 ( 4.6A)GIN A 600 ( 4.7A)GIN A 600 (-3.1A)GIN A 600 (-3.6A)GIN A 600 (-3.6A)NoneGIN A 600 (-4.7A)GIN A 600 (-4.0A) | 0.42A | 4agcA-2hz0A:31.6 | 4agcA-2hz0A:35.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2iwi | SERINE/THREONINE-PROTEIN KINASE PIM-2 (Homo sapiens) |
PF00069(Pkinase) | 6 | LEU A 38VAL A 46ALA A 59GLU A 83LEU A 87LEU A 170 | HB1 A1289 ( 4.1A)HB1 A1289 (-3.6A)HB1 A1289 ( 3.7A)NoneNoneHB1 A1289 (-4.7A) | 0.58A | 4agcA-2iwiA:21.0 | 4agcA-2iwiA:24.27 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2ogv | MACROPHAGECOLONY-STIMULATINGFACTOR 1 RECEPTORPRECURSOR (Homo sapiens) |
PF07714(Pkinase_Tyr) | 6 | LEU A 588VAL A 596ALA A 614GLU A 633GLY A 669LEU A 785 | None | 0.50A | 4agcA-2ogvA:41.0 | 4agcA-2ogvA:48.31 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2ogv | MACROPHAGECOLONY-STIMULATINGFACTOR 1 RECEPTORPRECURSOR (Homo sapiens) |
PF07714(Pkinase_Tyr) | 6 | LEU A 588VAL A 596ALA A 614LYS A 616GLU A 633GLY A 669 | None | 0.53A | 4agcA-2ogvA:41.0 | 4agcA-2ogvA:48.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2phk | PHOSPHORYLASE KINASE (Oryctolaguscuniculus) |
PF00069(Pkinase) | 6 | LEU A 25VAL A 33ALA A 46LEU A 77GLY A 109LEU A 156 | ATP A 381 ( 4.3A)ATP A 381 (-4.1A)ATP A 381 (-3.5A)NoneNoneATP A 381 ( 4.8A) | 0.47A | 4agcA-2phkA:21.8 | 4agcA-2phkA:23.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2phk | PHOSPHORYLASE KINASE (Oryctolaguscuniculus) |
PF00069(Pkinase) | 6 | LEU A 25VAL A 33LYS A 48LEU A 77GLY A 109LEU A 156 | ATP A 381 ( 4.3A)ATP A 381 (-4.1A)ATP A 381 (-3.2A)NoneNoneATP A 381 ( 4.8A) | 0.52A | 4agcA-2phkA:21.8 | 4agcA-2phkA:23.56 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2psq | FIBROBLAST GROWTHFACTOR RECEPTOR 2 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 7 | LEU A 487VAL A 495ALA A 515GLU A 534VAL A 564GLY A 570LEU A 633 | None | 0.55A | 4agcA-2psqA:34.5 | 4agcA-2psqA:50.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2r4b | RECEPTORTYROSINE-PROTEINKINASE ERBB-4 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 6 | LEU A 724VAL A 732ALA A 749LYS A 751GLY A 802LEU A 850 | GW7 A 1 ( 4.2A)GW7 A 1 ( 4.8A)GW7 A 1 (-3.3A)GW7 A 1 (-3.9A)GW7 A 1 (-3.6A)GW7 A 1 (-4.2A) | 0.58A | 4agcA-2r4bA:28.9 | 4agcA-2r4bA:35.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2w4k | DEATH-ASSOCIATEDPROTEIN KINASE 1 (Homo sapiens) |
PF00069(Pkinase) | 6 | LEU A 19VAL A 27ALA A 40LYS A 42GLU A 64LEU A 68 | ADP A1303 ( 3.9A)ADP A1303 (-4.0A)ADP A1303 (-3.5A)ADP A1303 (-2.7A)ADP A1303 ( 4.8A)None | 0.58A | 4agcA-2w4kA:21.9 | 4agcA-2w4kA:25.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xik | SERINE/THREONINEPROTEIN KINASE 25 (Homo sapiens) |
PF00069(Pkinase) | 6 | VAL A 34ALA A 47GLU A 66LEU A 70GLY A 101LEU A 147 | J60 A1294 ( 4.9A)J60 A1294 (-3.3A)NoneNoneJ60 A1294 ( 3.8A)J60 A1294 (-4.8A) | 0.55A | 4agcA-2xikA:17.8 | 4agcA-2xikA:27.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yab | DEATH-ASSOCIATEDPROTEIN KINASE 2 (Mus musculus) |
PF00069(Pkinase) | 6 | LEU A 19VAL A 27ALA A 40LYS A 42GLU A 64LEU A 68 | AMP A1302 (-3.7A)AMP A1302 (-4.2A)AMP A1302 (-3.6A)AMP A1302 (-2.8A)NoneNone | 0.60A | 4agcA-2yabA:21.9 | 4agcA-2yabA:25.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2z7r | RIBOSOMAL PROTEIN S6KINASE ALPHA-1 (Homo sapiens) |
PF00069(Pkinase) | 6 | LEU A 68VAL A 76ALA A 92LYS A 94GLY A 147LEU A 194 | STU A 1 (-3.8A)NoneSTU A 1 (-3.3A)STU A 1 (-2.8A)STU A 1 ( 3.9A)STU A 1 (-4.6A) | 0.44A | 4agcA-2z7rA:21.3 | 4agcA-2z7rA:27.82 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3b2t | FIBROBLAST GROWTHFACTOR RECEPTOR 2 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 7 | LEU A 487VAL A 495ALA A 515LYS A 517VAL A 564GLY A 570LEU A 633 | M33 A1996 (-4.0A)M33 A1996 ( 4.7A)M33 A1996 (-3.3A)M33 A1996 ( 4.5A)NoneM33 A1996 ( 4.8A)M33 A1996 (-4.5A) | 0.46A | 4agcA-3b2tA:24.9 | 4agcA-3b2tA:49.01 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3c4f | BASIC FIBROBLASTGROWTH FACTORRECEPTOR 1 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 7 | LEU A 484VAL A 492ALA A 512GLU A 531VAL A 561GLY A 567LEU A 630 | C4F A 1 ( 3.9A)NoneC4F A 1 (-3.3A)NoneC4F A 1 ( 4.8A)NoneC4F A 1 (-4.6A) | 0.59A | 4agcA-3c4fA:33.4 | 4agcA-3c4fA:54.78 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3d7u | TYROSINE-PROTEINKINASE CSK (Homo sapiens) |
PF07714(Pkinase_Tyr) | 6 | VAL A 209ALA A 220LYS A 222GLU A 236GLY A 272LEU A 321 | None | 0.54A | 4agcA-3d7uA:25.2 | 4agcA-3d7uA:32.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3f2a | PROTO-ONCOGENESERINE/THREONINE-PROTEIN KINASE PIM-1 (Homo sapiens) |
PF00069(Pkinase) | 7 | LEU A 44VAL A 52ALA A 65LYS A 67GLU A 89LEU A 93LEU A 174 | 985 A 1 (-4.1A)985 A 1 (-4.5A)985 A 1 (-3.5A)985 A 1 ( 2.8A) MG A 314 (-3.6A) MG A 314 ( 4.8A)985 A 1 (-4.8A) | 0.54A | 4agcA-3f2aA:16.3 | 4agcA-3f2aA:28.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3hng | VASCULAR ENDOTHELIALGROWTH FACTORRECEPTOR 1 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 11 | LEU A 833VAL A 841ALA A 859LYS A 861GLU A 878LEU A 882VAL A 909GLY A 915LEU A1029CYH A1039PHE A1041 | 8ST A2001 ( 4.7A)8ST A2001 ( 4.6A)8ST A2001 ( 3.8A)8ST A2001 (-4.0A)8ST A2001 (-3.7A)None8ST A2001 (-4.1A)NoneNone8ST A2001 (-4.2A)8ST A2001 ( 3.7A) | 0.51A | 4agcA-3hngA:42.0 | 4agcA-3hngA:67.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mvj | CAMP-DEPENDENTPROTEIN KINASECATALYTIC SUBUNITALPHA (Homo sapiens) |
PF00069(Pkinase) | 7 | LEU A 49VAL A 57ALA A 70GLU A 91LEU A 95GLY A 126LEU A 173 | XFE A 351 (-4.2A)XFE A 351 ( 4.5A)XFE A 351 (-3.2A)NoneNoneNoneXFE A 351 (-4.6A) | 0.52A | 4agcA-3mvjA:20.8 | 4agcA-3mvjA:25.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mvj | CAMP-DEPENDENTPROTEIN KINASECATALYTIC SUBUNITALPHA (Homo sapiens) |
PF00069(Pkinase) | 6 | LEU A 49VAL A 57ALA A 70LYS A 72GLU A 91LEU A 95 | XFE A 351 (-4.2A)XFE A 351 ( 4.5A)XFE A 351 (-3.2A)NoneNoneNone | 0.52A | 4agcA-3mvjA:20.8 | 4agcA-3mvjA:25.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nuu | PKB-LIKE (Homo sapiens) |
PF00069(Pkinase) | 7 | LEU A 88VAL A 96ALA A 109LYS A 111GLU A 130GLY A 165LEU A 212 | JOZ A 361 (-4.1A)JOZ A 361 ( 4.7A)JOZ A 361 (-3.4A)SO4 A 5 (-2.8A)SO4 A 5 (-3.1A)NoneNone | 0.51A | 4agcA-3nuuA:22.6 | 4agcA-3nuuA:25.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nyo | G PROTEIN-COUPLEDRECEPTOR KINASE 6 (Homo sapiens) |
PF00069(Pkinase)PF00615(RGS) | 8 | LEU A 192VAL A 200ALA A 213LYS A 215GLU A 234LEU A 238GLY A 269LEU A 318 | AMP A 577 ( 4.3A)AMP A 577 (-4.3A)AMP A 577 (-3.4A)AMP A 577 (-2.8A)NoneNoneNoneAMP A 577 (-4.8A) | 0.76A | 4agcA-3nyoA:21.1 | 4agcA-3nyoA:22.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pp0 | RECEPTORTYROSINE-PROTEINKINASE ERBB-2 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 6 | LEU A 726VAL A 734ALA A 751LYS A 753GLY A 804LEU A 852 | 03Q A 1 (-3.8A)03Q A 1 (-4.5A)03Q A 1 (-3.1A)03Q A 1 (-4.7A)03Q A 1 ( 3.9A)03Q A 1 (-4.4A) | 0.50A | 4agcA-3pp0A:29.7 | 4agcA-3pp0A:28.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3q5i | PROTEIN KINASE (Plasmodiumberghei) |
PF00069(Pkinase)PF13499(EF-hand_7) | 7 | LEU A 63VAL A 71ALA A 84LYS A 86LEU A 119GLY A 150LEU A 197 | ANP A1634 ( 4.3A)ANP A1634 (-4.1A)ANP A1634 (-3.6A)ANP A1634 (-3.1A)NoneNoneANP A1634 (-4.4A) | 0.55A | 4agcA-3q5iA:19.6 | 4agcA-3q5iA:22.57 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3tt0 | BASIC FIBROBLASTGROWTH FACTORRECEPTOR 1 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 8 | LEU A 484VAL A 492ALA A 512LYS A 514GLU A 531VAL A 561GLY A 567LEU A 630 | 07J A 1 ( 4.3A)07J A 1 (-4.0A)07J A 1 (-3.5A)07J A 1 (-4.5A)07J A 1 (-3.8A)07J A 1 (-4.7A)07J A 1 (-3.7A)07J A 1 ( 4.4A) | 0.60A | 4agcA-3tt0A:34.6 | 4agcA-3tt0A:50.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3txo | PROTEIN KINASE C ETATYPE (Homo sapiens) |
PF00069(Pkinase)PF00433(Pkinase_C) | 7 | LEU A 361VAL A 369ALA A 382GLU A 403LEU A 407GLY A 439LEU A 486 | 07U A 1 ( 4.8A)07U A 1 (-4.8A)07U A 1 (-3.3A)07U A 1 ( 4.8A)NoneNone07U A 1 (-4.3A) | 0.68A | 4agcA-3txoA:13.1 | 4agcA-3txoA:23.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3txo | PROTEIN KINASE C ETATYPE (Homo sapiens) |
PF00069(Pkinase)PF00433(Pkinase_C) | 7 | LEU A 361VAL A 369ALA A 382LYS A 384GLU A 403LEU A 407LEU A 486 | 07U A 1 ( 4.8A)07U A 1 (-4.8A)07U A 1 (-3.3A)07U A 1 (-3.0A)07U A 1 ( 4.8A)None07U A 1 (-4.3A) | 0.65A | 4agcA-3txoA:13.1 | 4agcA-3txoA:23.89 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3vid | VASCULAR ENDOTHELIALGROWTH FACTORRECEPTOR 2 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 9 | LEU A 840VAL A 848ALA A 866GLU A 885LEU A 889VAL A 916GLY A 922LEU A1035CYH A1045 | 4TT A2001 ( 4.0A)4TT A2001 ( 4.5A)4TT A2001 (-3.5A)NoneNoneNone4TT A2001 (-3.7A)4TT A2001 (-4.8A)None | 0.44A | 4agcA-3vidA:30.0 | 4agcA-3vidA:85.96 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3vid | VASCULAR ENDOTHELIALGROWTH FACTORRECEPTOR 2 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 7 | LEU A 840VAL A 848ALA A 866LYS A 868GLU A 885LEU A 889VAL A 916 | 4TT A2001 ( 4.0A)4TT A2001 ( 4.5A)4TT A2001 (-3.5A)NoneNoneNoneNone | 0.56A | 4agcA-3vidA:30.0 | 4agcA-3vidA:85.96 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3wzd | VASCULAR ENDOTHELIALGROWTH FACTORRECEPTOR 2 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 9 | LEU A 840VAL A 848ALA A 866GLU A 885LEU A 889VAL A 916GLY A 922LEU A1035CYH A1045 | LEV A1201 ( 3.8A)LEV A1201 ( 4.9A)LEV A1201 (-3.5A)LEV A1201 (-3.7A)LEV A1201 ( 4.4A)LEV A1201 ( 4.6A)LEV A1201 (-3.6A)LEV A1201 (-4.8A)GOL A1210 ( 3.3A) | 0.46A | 4agcA-3wzdA:38.3 | 4agcA-3wzdA:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4agd | VASCULAR ENDOTHELIALGROWTH FACTORRECEPTOR 2 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 10 | ILE A 804LEU A 840VAL A 848ALA A 866GLU A 885VAL A 916GLY A 922LEU A1035CYH A1045PHE A1047 | NoneB49 A2000 (-3.7A)NoneB49 A2000 (-3.5A)NoneB49 A2000 (-4.8A)B49 A2000 ( 3.7A)B49 A2000 (-4.5A)B49 A2000 ( 4.1A)B49 A2000 (-4.0A) | 0.42A | 4agcA-4agdA:48.6 | 4agcA-4agdA:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4agd | VASCULAR ENDOTHELIALGROWTH FACTORRECEPTOR 2 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 10 | ILE A 804LEU A 840VAL A 848ALA A 866LYS A 868GLU A 885GLY A 922LEU A1035CYH A1045PHE A1047 | NoneB49 A2000 (-3.7A)NoneB49 A2000 (-3.5A)B49 A2000 (-3.0A)NoneB49 A2000 ( 3.7A)B49 A2000 (-4.5A)B49 A2000 ( 4.1A)B49 A2000 (-4.0A) | 0.52A | 4agcA-4agdA:48.6 | 4agcA-4agdA:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4agd | VASCULAR ENDOTHELIALGROWTH FACTORRECEPTOR 2 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 10 | LEU A 840VAL A 848ALA A 866GLU A 885LEU A 889VAL A 916GLY A 922LEU A1035CYH A1045PHE A1047 | B49 A2000 (-3.7A)NoneB49 A2000 (-3.5A)NoneNoneB49 A2000 (-4.8A)B49 A2000 ( 3.7A)B49 A2000 (-4.5A)B49 A2000 ( 4.1A)B49 A2000 (-4.0A) | 0.45A | 4agcA-4agdA:48.6 | 4agcA-4agdA:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4agd | VASCULAR ENDOTHELIALGROWTH FACTORRECEPTOR 2 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 10 | LEU A 840VAL A 848ALA A 866LYS A 868GLU A 885LEU A 889GLY A 922LEU A1035CYH A1045PHE A1047 | B49 A2000 (-3.7A)NoneB49 A2000 (-3.5A)B49 A2000 (-3.0A)NoneNoneB49 A2000 ( 3.7A)B49 A2000 (-4.5A)B49 A2000 ( 4.1A)B49 A2000 (-4.0A) | 0.56A | 4agcA-4agdA:48.6 | 4agcA-4agdA:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4agu | CYCLIN-DEPENDENTKINASE-LIKE 1 (Homo sapiens) |
PF00069(Pkinase) | 7 | VAL A 18ALA A 31LYS A 33GLU A 51LEU A 55LEU A 133CYH A 143 | D15 A 500 (-4.6A)D15 A 500 (-3.4A)D15 A 500 ( 4.1A)NoneNoneD15 A 500 (-4.5A)D15 A 500 ( 4.0A) | 0.60A | 4agcA-4aguA:22.2 | 4agcA-4aguA:25.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4aw2 | SERINE/THREONINE-PROTEIN KINASE MRCKALPHA (Rattusnorvegicus) |
PF00069(Pkinase)PF00433(Pkinase_C) | 7 | VAL A 91ALA A 104LYS A 106GLU A 125LEU A 129GLY A 160LEU A 208 | NoneEDO A1420 (-3.4A)EDO A1419 (-3.3A)EDO A1419 (-3.0A)NoneNoneEDO A1420 ( 4.8A) | 0.68A | 4agcA-4aw2A:19.3 | 4agcA-4aw2A:22.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4c0t | LIKELY PROTEINKINASE (Candidaalbicans) |
PF00069(Pkinase) | 7 | LEU A 246VAL A 254ALA A 267GLU A 288LEU A 292GLY A 324LEU A 371 | None | 0.75A | 4agcA-4c0tA:22.0 | 4agcA-4c0tA:16.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4c0t | LIKELY PROTEINKINASE (Candidaalbicans) |
PF00069(Pkinase) | 7 | LEU A 246VAL A 254ALA A 267LYS A 269LEU A 292GLY A 324LEU A 371 | None | 0.60A | 4agcA-4c0tA:22.0 | 4agcA-4c0tA:16.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4crs | SERINE/THREONINE-PROTEIN KINASE N2 (Homo sapiens) |
PF00069(Pkinase)PF00433(Pkinase_C) | 6 | LEU A 663VAL A 671ALA A 684LYS A 686GLY A 743LEU A 789 | AGS A1985 (-4.2A)AGS A1985 (-4.6A)AGS A1985 (-3.5A)AGS A1985 (-3.0A)NoneAGS A1985 (-4.8A) | 0.52A | 4agcA-4crsA:15.2 | 4agcA-4crsA:23.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4eut | SERINE/THREONINE-PROTEIN KINASE TBK1 (Homo sapiens) |
PF00069(Pkinase) | 7 | LEU A 15VAL A 23ALA A 36LYS A 38GLU A 55LEU A 59GLY A 92 | BX7 A 401 (-3.7A)BX7 A 401 (-4.4A)BX7 A 401 (-3.4A)BX7 A 401 ( 4.0A)NoneNoneBX7 A 401 (-3.5A) | 0.51A | 4agcA-4eutA:19.3 | 4agcA-4eutA:22.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4euu | SERINE/THREONINE-PROTEIN KINASE TBK1 (Homo sapiens) |
PF00069(Pkinase) | 7 | LEU A 15VAL A 23ALA A 36LYS A 38GLU A 55LEU A 59GLY A 92 | BX7 A 401 (-3.9A)BX7 A 401 ( 4.6A)BX7 A 401 (-3.4A)BX7 A 401 (-3.5A)NoneNoneBX7 A 401 (-3.3A) | 0.43A | 4agcA-4euuA:21.6 | 4agcA-4euuA:24.74 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4f4p | TYROSINE-PROTEINKINASE SYK (Homo sapiens) |
PF07714(Pkinase_Tyr) | 7 | LEU A 377VAL A 385ALA A 400LYS A 402GLU A 420GLY A 454LEU A 501 | 0SB A 701 ( 3.9A)0SB A 701 (-4.0A)0SB A 701 (-3.3A)0SB A 701 ( 4.8A)None0SB A 701 (-3.5A)0SB A 701 (-4.4A) | 0.89A | 4agcA-4f4pA:30.0 | 4agcA-4f4pA:34.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4f99 | CELL DIVISION CYCLE7-RELATED PROTEINKINASE (Homo sapiens) |
PF00069(Pkinase) | 6 | VAL A 72ALA A 88LYS A 90GLU A 104LEU A 108LEU A 184 | ADP A 601 (-4.0A)ADP A 601 (-3.5A)ADP A 601 (-2.6A)NoneNoneADP A 601 ( 4.9A) | 0.55A | 4agcA-4f99A:13.7 | 4agcA-4f99A:22.34 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4fod | ALK TYROSINE KINASERECEPTOR (Homo sapiens) |
PF07714(Pkinase_Tyr) | 7 | LEU A1122VAL A1130ALA A1148LYS A1150GLU A1167GLY A1202LEU A1256 | 0UV A1501 (-3.8A)0UV A1501 (-4.5A)0UV A1501 (-3.4A)0UV A1501 (-3.7A)None0UV A1501 (-3.6A)0UV A1501 (-4.6A) | 0.88A | 4agcA-4fodA:24.4 | 4agcA-4fodA:33.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4g3f | NF-KAPPA-BETA-INDUCING KINASE (Mus musculus) |
PF00069(Pkinase) | 6 | VAL A 416ALA A 429GLU A 442GLY A 477LEU A 524CYH A 535 | 0WB A 701 (-4.4A)0WB A 701 (-3.3A)0WB A 701 (-3.2A)0WB A 701 ( 4.5A)0WB A 701 (-4.3A)0WB A 701 ( 3.7A) | 0.53A | 4agcA-4g3fA:21.3 | 4agcA-4g3fA:25.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gv1 | RAC-ALPHASERINE/THREONINE-PROTEIN KINASE (Homo sapiens) |
PF00069(Pkinase)PF00433(Pkinase_C) | 7 | LEU A 156VAL A 164ALA A 177LYS A 179GLU A 198LEU A 202GLY A 233 | 0XZ A 501 ( 4.1A)0XZ A 501 (-4.5A)0XZ A 501 (-3.3A)GOL A 503 ( 2.8A)GOL A 503 (-3.6A)NoneNone | 0.67A | 4agcA-4gv1A:20.6 | 4agcA-4gv1A:23.20 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4hvi | TYROSINE-PROTEINKINASE JAK3 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 7 | LEU A 828VAL A 836ALA A 853LYS A 855GLU A 871GLY A 908LEU A 956 | 19S A1201 (-3.9A)19S A1201 (-4.4A)19S A1201 (-3.3A)19S A1201 (-3.5A)None19S A1201 ( 3.8A)19S A1201 (-4.5A) | 0.44A | 4agcA-4hviA:29.8 | 4agcA-4hviA:31.32 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4hzs | ACTIVATED CDC42KINASE 1 (Homo sapiens) |
PF07714(Pkinase_Tyr)PF14604(SH3_9) | 6 | LEU A 132VAL A 140ALA A 156LYS A 158GLY A 211LEU A 259 | None | 0.43A | 4agcA-4hzsA:27.0 | 4agcA-4hzsA:30.81 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4id7 | ACTIVATED CDC42KINASE 1 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 6 | LEU A 132VAL A 140ALA A 156LYS A 158GLY A 211LEU A 259 | 1G0 A 401 ( 4.5A)1G0 A 401 (-4.4A)1G0 A 401 (-3.6A)1G0 A 401 (-3.7A)1G0 A 401 ( 4.5A)1G0 A 401 (-4.6A) | 0.47A | 4agcA-4id7A:29.4 | 4agcA-4id7A:33.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4idt | MITOGEN-ACTIVATEDPROTEIN KINASEKINASE KINASE 14 (Homo sapiens) |
PF00069(Pkinase) | 7 | LEU A 406VAL A 414LYS A 429GLU A 440GLY A 475LEU A 522CYH A 533 | T28 A 701 (-3.8A)T28 A 701 (-4.7A)T28 A 701 ( 3.8A)NoneT28 A 701 ( 3.0A)T28 A 701 (-3.9A)T28 A 701 (-3.7A) | 0.74A | 4agcA-4idtA:21.5 | 4agcA-4idtA:26.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jxf | SERINE/THREONINE-PROTEIN KINASE PLK4 (Homo sapiens) |
PF00069(Pkinase) | 6 | LEU A 18VAL A 26ALA A 39LYS A 41GLY A 95LEU A 143 | 631 A 301 (-3.4A)631 A 301 (-4.6A)631 A 301 (-3.3A)631 A 301 (-2.7A)631 A 301 ( 3.7A)631 A 301 (-4.0A) | 0.53A | 4agcA-4jxfA:8.5 | 4agcA-4jxfA:23.76 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4k33 | FIBROBLAST GROWTHFACTOR RECEPTOR 3 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 8 | LEU A 478VAL A 486ALA A 506LYS A 508GLU A 525VAL A 555GLY A 561LEU A 624 | ACP A 801 (-3.8A)ACP A 801 (-4.2A)ACP A 801 (-3.3A)ACP A 801 (-2.7A)ACP A 801 ( 4.8A)ACP A 801 (-4.7A)ACP A 801 ( 4.6A)ACP A 801 (-4.4A) | 0.63A | 4agcA-4k33A:25.9 | 4agcA-4k33A:51.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4l52 | MITOGEN-ACTIVATEDPROTEIN KINASEKINASE KINASE 7,TGF-BETA-ACTIVATEDKINASE 1 ANDMAP3K7-BINDINGPROTEIN 1 CHIMERA (Homo sapiens) |
PF07714(Pkinase_Tyr) | 7 | VAL A 50ALA A 61GLU A 77LEU A 81GLY A 110LEU A 163CYH A 174 | 1UL A 501 ( 4.9A)1UL A 501 (-3.1A)NoneNone1UL A 501 ( 3.7A)1UL A 501 (-4.3A)1UL A 501 (-3.6A) | 0.62A | 4agcA-4l52A:19.2 | 4agcA-4l52A:28.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4o27 | SERINE/THREONINE-PROTEIN KINASE 24 (Homo sapiens) |
PF00069(Pkinase) | 7 | VAL B 38ALA B 51LYS B 53GLU B 70LEU B 74GLY B 105LEU B 151 | ADP B 500 (-4.5A)ADP B 500 (-3.3A)ADP B 500 (-3.1A)NoneNoneNoneADP B 500 (-4.7A) | 0.75A | 4agcA-4o27B:17.1 | 4agcA-4o27B:25.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4o38 | CYCLIN-G-ASSOCIATEDKINASE (Homo sapiens) |
PF00069(Pkinase) | 8 | LEU A 46VAL A 54ALA A 67LYS A 69GLU A 85GLY A 128LEU A 180CYH A 190 | SIN A 401 ( 3.9A)NoneSIN A 401 ( 3.7A)NoneNoneSIN A 401 (-3.5A)SIN A 401 ( 4.5A)None | 0.68A | 4agcA-4o38A:20.0 | 4agcA-4o38A:24.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4oli | NON-RECEPTORTYROSINE-PROTEINKINASE TYK2 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 6 | LEU A 903VAL A 911ALA A 928GLU A 947GLY A 984LEU A1030 | 2TT A1202 (-3.5A)2TT A1202 (-4.5A)2TT A1202 ( 3.9A)None2TT A1202 (-3.4A)2TT A1202 (-4.4A) | 0.45A | 4agcA-4oliA:27.5 | 4agcA-4oliA:24.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4otd | SERINE/THREONINE-PROTEIN KINASE N1 (Homo sapiens) |
PF00069(Pkinase)PF00433(Pkinase_C) | 6 | LEU A 627VAL A 635ALA A 648LEU A 673GLY A 707LEU A 753 | None | 0.53A | 4agcA-4otdA:21.2 | 4agcA-4otdA:26.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4q9z | HUMAN PROTEIN KINASEC THETA (Homo sapiens) |
PF00069(Pkinase)PF00433(Pkinase_C) | 6 | LEU A 386VAL A 394ALA A 407LYS A 409LEU A 432LEU A 511 | PZW A 801 (-3.9A)PZW A 801 (-4.6A)PZW A 801 (-3.5A)NoneNonePZW A 801 (-4.8A) | 0.57A | 4agcA-4q9zA:19.6 | 4agcA-4q9zA:24.64 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4rt7 | RECEPTOR-TYPETYROSINE-PROTEINKINASE FLT3 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 9 | LEU A 616VAL A 624ALA A 642LYS A 644GLU A 661GLY A 697LEU A 818CYH A 828PHE A 830 | P30 A1001 (-3.8A)NoneP30 A1001 (-3.4A)P30 A1001 (-3.4A)P30 A1001 (-3.6A)P30 A1001 (-3.4A)P30 A1001 (-4.6A)P30 A1001 (-4.1A)P30 A1001 (-3.9A) | 0.30A | 4agcA-4rt7A:31.3 | 4agcA-4rt7A:43.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wb7 | DNAJ HOMOLOGSUBFAMILY B MEMBER1,CAMP-DEPENDENTPROTEIN KINASECATALYTIC SUBUNITALPHA (Homo sapiens) |
PF00069(Pkinase)PF00226(DnaJ) | 7 | LEU A 104VAL A 112ALA A 125LYS A 127GLU A 146GLY A 181LEU A 228 | ATP A 501 ( 4.3A)ATP A 501 (-4.0A)ATP A 501 (-3.4A)ATP A 501 (-2.6A)NoneNoneATP A 501 (-4.5A) | 0.56A | 4agcA-4wb7A:20.6 | 4agcA-4wb7A:23.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wb7 | DNAJ HOMOLOGSUBFAMILY B MEMBER1,CAMP-DEPENDENTPROTEIN KINASECATALYTIC SUBUNITALPHA (Homo sapiens) |
PF00069(Pkinase)PF00226(DnaJ) | 7 | LEU A 104VAL A 112ALA A 125LYS A 127LEU A 150GLY A 181LEU A 228 | ATP A 501 ( 4.3A)ATP A 501 (-4.0A)ATP A 501 (-3.4A)ATP A 501 (-2.6A)NoneNoneATP A 501 (-4.5A) | 0.60A | 4agcA-4wb7A:20.6 | 4agcA-4wb7A:23.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wbo | RHODOPSIN KINASE (Bos taurus) |
PF00069(Pkinase)PF00615(RGS) | 7 | LEU A 193VAL A 201ALA A 214LYS A 216LEU A 239GLY A 270LEU A 321 | ANW A 601 ( 4.0A)NoneANW A 601 (-3.4A)NoneNoneANW A 601 ( 4.5A)ANW A 601 (-4.9A) | 0.62A | 4agcA-4wboA:22.0 | 4agcA-4wboA:21.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wsq | AP2-ASSOCIATEDPROTEIN KINASE 1 (Homo sapiens) |
PF00069(Pkinase) | 6 | LEU A 52VAL A 60ALA A 72GLY A 132LEU A 183CYH A 193 | KSA A 405 ( 4.0A)KSA A 405 ( 4.9A)KSA A 405 (-3.2A)KSA A 405 (-3.5A)KSA A 405 (-4.6A)KSA A 405 (-3.4A) | 0.36A | 4agcA-4wsqA:22.5 | 4agcA-4wsqA:24.38 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4xcu | FIBROBLAST GROWTHFACTOR RECEPTOR 4 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 6 | LEU A 473VAL A 481ALA A 501LYS A 503GLU A 520VAL A 550 | 40M A1002 ( 4.6A)40M A1002 ( 4.5A)40M A1002 ( 4.1A)40M A1002 (-4.0A)40M A1002 (-3.7A)40M A1002 (-4.7A) | 0.59A | 4agcA-4xcuA:33.7 | 4agcA-4xcuA:47.04 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4xuf | RECEPTOR-TYPETYROSINE-PROTEINKINASE FLT3 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 8 | LEU A 616VAL A 624ALA A 642GLU A 661GLY A 697LEU A 818CYH A 828PHE A 830 | P30 A1001 (-4.0A)P30 A1001 ( 4.8A)P30 A1001 (-3.5A)P30 A1001 (-3.1A)P30 A1001 (-3.5A)P30 A1001 (-4.3A)P30 A1001 (-4.8A)P30 A1001 ( 4.1A) | 0.59A | 4agcA-4xufA:39.1 | 4agcA-4xufA:51.75 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4xuf | RECEPTOR-TYPETYROSINE-PROTEINKINASE FLT3 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 8 | LEU A 616VAL A 624ALA A 642LYS A 644GLU A 661GLY A 697LEU A 818PHE A 830 | P30 A1001 (-4.0A)P30 A1001 ( 4.8A)P30 A1001 (-3.5A)P30 A1001 ( 4.0A)P30 A1001 (-3.1A)P30 A1001 (-3.5A)P30 A1001 (-4.3A)P30 A1001 ( 4.1A) | 0.72A | 4agcA-4xufA:39.1 | 4agcA-4xufA:51.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ysj | CALMODULIN-LIKEDOMAIN PROTEINKINASE (Eimeria tenella) |
PF00069(Pkinase)PF13499(EF-hand_7) | 8 | LEU A 34VAL A 42ALA A 55LYS A 57GLU A 76LEU A 80GLY A 111LEU A 158 | ADP A 506 ( 3.8A)ADP A 506 (-4.3A)ADP A 506 (-3.3A)ADP A 506 (-2.4A)NoneNoneNoneADP A 506 (-4.7A) | 0.53A | 4agcA-4ysjA:21.9 | 4agcA-4ysjA:23.28 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5a46 | FIBROBLAST GROWTHFACTOR RECEPTOR 1(FMS-RELATEDTYROSINE KINASE 2,PFEIFFER SYNDROME),ISOFORM CRA_B (Homo sapiens) |
PF07714(Pkinase_Tyr) | 8 | LEU A 484VAL A 492ALA A 512LYS A 514GLU A 531VAL A 561GLY A 567LEU A 630 | 38O A1769 (-3.2A)38O A1769 (-4.5A)38O A1769 (-3.6A)38O A1769 ( 3.1A)EDO A1766 (-4.1A)38O A1769 (-4.3A)38O A1769 (-3.4A)38O A1769 (-4.6A) | 0.60A | 4agcA-5a46A:34.6 | 4agcA-5a46A:45.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5e8y | TGF-BETA RECEPTORTYPE-2 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 6 | VAL A 258ALA A 275LYS A 277GLY A 331LEU A 386CYH A 396 | STU A 601 (-4.0A)STU A 601 (-3.1A)STU A 601 (-2.4A)STU A 601 (-3.5A)STU A 601 (-3.9A)STU A 601 (-3.2A) | 0.46A | 4agcA-5e8yA:24.3 | 4agcA-5e8yA:27.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5eyk | AURORA KINASE B-A (Xenopus laevis) |
PF00069(Pkinase) | 6 | LEU A 99VAL A 107ALA A 120LYS A 122GLY A 176LEU A 223 | 5U5 A 401 (-3.8A)5U5 A 401 ( 4.3A)5U5 A 401 (-3.5A)5U5 A 401 (-2.6A)5U5 A 401 (-3.4A)5U5 A 401 (-4.7A) | 0.36A | 4agcA-5eykA:22.1 | 4agcA-5eykA:25.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5f1z | NON-RECEPTORTYROSINE-PROTEINKINASE TYK2 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 7 | LEU A 903VAL A 911ALA A 928LYS A 930GLU A 947GLY A 984LEU A1030 | 5U3 A1200 (-3.8A)5U3 A1200 ( 4.4A)5U3 A1200 (-3.5A)NoneNone5U3 A1200 (-3.2A)5U3 A1200 (-4.4A) | 0.53A | 4agcA-5f1zA:28.2 | 4agcA-5f1zA:28.84 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5fm2 | PROTO-ONCOGENETYROSINE-PROTEINKINASE RECEPTOR RET (Homo sapiens) |
PF07714(Pkinase_Tyr) | 7 | LEU A 730VAL A 738ALA A 756LYS A 758GLU A 775LEU A 779VAL A 804 | PP1 A2012 (-4.6A)PP1 A2012 (-4.4A)PP1 A2012 (-3.2A)PP1 A2012 (-4.1A)PP1 A2012 (-3.5A)NonePP1 A2012 (-4.5A) | 0.64A | 4agcA-5fm2A:32.4 | 4agcA-5fm2A:41.29 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5fm2 | PROTO-ONCOGENETYROSINE-PROTEINKINASE RECEPTOR RET (Homo sapiens) |
PF07714(Pkinase_Tyr) | 7 | LEU A 730VAL A 738ALA A 756LYS A 758LEU A 779VAL A 804GLY A 810 | PP1 A2012 (-4.6A)PP1 A2012 (-4.4A)PP1 A2012 (-3.2A)PP1 A2012 (-4.1A)NonePP1 A2012 (-4.5A)PTR A 809 (-2.4A) | 0.65A | 4agcA-5fm2A:32.4 | 4agcA-5fm2A:41.29 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5fm2 | PROTO-ONCOGENETYROSINE-PROTEINKINASE RECEPTOR RET (Homo sapiens) |
PF07714(Pkinase_Tyr) | 7 | LEU A 730VAL A 738ALA A 756LYS A 758VAL A 804GLY A 810LEU A 881 | PP1 A2012 (-4.6A)PP1 A2012 (-4.4A)PP1 A2012 (-3.2A)PP1 A2012 (-4.1A)PP1 A2012 (-4.5A)PTR A 809 (-2.4A)PP1 A2012 (-4.6A) | 0.61A | 4agcA-5fm2A:32.4 | 4agcA-5fm2A:41.29 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5grn | PLATELET-DERIVEDGROWTH FACTORRECEPTOR ALPHA (Homo sapiens) |
PF07714(Pkinase_Tyr) | 9 | LEU A 599VAL A 607ALA A 625LYS A 627GLU A 644GLY A 680LEU A 825CYH A 835PHE A 837 | 748 A1001 (-3.8A)748 A1001 ( 4.7A)748 A1001 (-3.7A)748 A1001 (-4.0A)748 A1001 (-3.3A)748 A1001 ( 4.0A)748 A1001 (-4.3A)748 A1001 (-4.5A)748 A1001 (-3.7A) | 0.45A | 4agcA-5grnA:32.3 | 4agcA-5grnA:48.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hu3 | CALCIUM/CALMODULIN-DEPENDENT PROTEINKINASE TYPE II ALPHACHAIN (Drosophilamelanogaster) |
PF00069(Pkinase) | 7 | LEU A 20VAL A 28ALA A 41LYS A 43GLU A 61GLY A 96LEU A 143 | ADP A 301 ( 4.0A)ADP A 301 (-3.7A)ADP A 301 (-3.5A)ADP A 301 (-2.7A)NoneNoneADP A 301 (-4.7A) | 0.63A | 4agcA-5hu3A:22.3 | 4agcA-5hu3A:23.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5i3o | BMP-2-INDUCIBLEPROTEIN KINASE (Homo sapiens) |
PF00069(Pkinase) | 6 | LEU A 57VAL A 65ALA A 77GLY A 136LEU A 187CYH A 197 | IDV A 401 (-3.8A)IDV A 401 (-4.6A)IDV A 401 (-3.6A)IDV A 401 (-3.4A)IDV A 401 (-4.4A)IDV A 401 (-3.6A) | 0.44A | 4agcA-5i3oA:22.3 | 4agcA-5i3oA:22.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5j5t | MITOGEN-ACTIVATEDPROTEIN KINASEKINASE KINASE KINASE3 (Homo sapiens) |
PF00069(Pkinase) | 6 | VAL A 30ALA A 43LYS A 45GLU A 61GLY A 96LEU A 143 | 6G2 A 901 ( 4.9A)6G2 A 901 (-3.2A)6G2 A 901 ( 3.9A)None6G2 A 901 (-3.6A)6G2 A 901 (-4.7A) | 0.59A | 4agcA-5j5tA:20.5 | 4agcA-5j5tA:21.50 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5j9z | EPIDERMAL GROWTHFACTOR RECEPTOR (Homo sapiens) |
PF07714(Pkinase_Tyr) | 6 | LEU A 718VAL A 726ALA A 743LYS A 745GLY A 796LEU A 844 | 6HJ A1101 ( 4.6A)6HJ A1101 ( 4.7A)6HJ A1101 (-3.1A)6HJ A1101 (-4.2A)6HJ A1101 ( 4.5A)6HJ A1101 ( 4.8A) | 0.53A | 4agcA-5j9zA:30.6 | 4agcA-5j9zA:31.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5tur | SERINE/THREONINE-PROTEIN KINASE PIM-1 (Homo sapiens) |
no annotation | 7 | LEU A 44VAL A 52ALA A 65LYS A 67GLU A 89LEU A 93LEU A 174 | None7LK A 401 (-4.9A)7LK A 401 (-3.3A)NoneNoneNone7LK A 401 (-4.8A) | 0.52A | 4agcA-5turA:21.1 | 4agcA-5turA:26.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vil | MITOGEN-ACTIVATEDPROTEIN KINASEKINASE KINASE 5 (Homo sapiens) |
no annotation | 7 | LEU A 686VAL A 694ALA A 707LYS A 709GLU A 725GLY A 760LEU A 810 | 9E1 A1001 (-3.7A)9E1 A1001 ( 4.0A)9E1 A1001 (-3.5A)9E1 A1001 (-2.8A)None9E1 A1001 (-3.4A)9E1 A1001 (-4.5A) | 0.43A | 4agcA-5vilA:18.0 | 4agcA-5vilA:12.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6c7y | TYROSINE-PROTEINKINASE JAK1 (Homo sapiens) |
no annotation | 7 | LEU A 881VAL A 889ALA A 906LYS A 908GLU A 925GLY A 962LEU A1010 | ADP A1201 ( 4.5A)ADP A1201 (-4.3A)ADP A1201 (-3.4A)ADP A1201 (-2.8A)NoneADP A1201 ( 4.1A)ADP A1201 (-4.5A) | 0.58A | 4agcA-6c7yA:27.7 | 4agcA-6c7yA:13.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6fek | PROTO-ONCOGENETYROSINE-PROTEINKINASE RECEPTOR RET (Homo sapiens) |
no annotation | 6 | LEU A 730VAL A 738ALA A 756GLU A 775LEU A 779VAL A 804 | ADN A1104 ( 4.0A)ADN A1104 (-4.4A)ADN A1104 (-3.4A)NoneNoneADN A1104 ( 4.6A) | 0.50A | 4agcA-6fekA:31.9 | 4agcA-6fekA:23.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6fek | PROTO-ONCOGENETYROSINE-PROTEINKINASE RECEPTOR RET (Homo sapiens) |
no annotation | 7 | LEU A 730VAL A 738ALA A 756LEU A 779VAL A 804GLY A 810LEU A 881 | ADN A1104 ( 4.0A)ADN A1104 (-4.4A)ADN A1104 (-3.4A)NoneADN A1104 ( 4.6A)ADN A1104 ( 3.8A)ADN A1104 (-4.3A) | 0.58A | 4agcA-6fekA:31.9 | 4agcA-6fekA:23.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6fyl | DUAL SPECIFICITYPROTEIN KINASE CLK2 (Homo sapiens) |
no annotation | 7 | LEU A 169VAL A 177ALA A 191LYS A 193LEU A 212GLY A 247LEU A 297 | 3NG A 501 (-3.9A)3NG A 501 ( 4.4A)3NG A 501 (-3.3A)3NG A 501 (-3.0A)NoneNoneNone | 1.04A | 4agcA-6fylA:21.7 | 4agcA-6fylA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6fyv | DUAL SPECIFICITYPROTEIN KINASE CLK4 (Homo sapiens) |
no annotation | 8 | LEU A 167VAL A 175ALA A 189LYS A 191GLU A 206LEU A 210GLY A 245LEU A 295 | 3NG A 501 (-3.9A)3NG A 501 ( 4.3A)3NG A 501 (-3.5A)3NG A 501 (-2.7A)3NG A 501 ( 4.7A)NoneNoneNone | 1.15A | 4agcA-6fyvA:21.4 | 4agcA-6fyvA:undetectable |