SIMILAR PATTERNS OF AMINO ACIDS FOR 4AGA_A_ACTA1131_0
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1dbv | GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE (Geobacillusstearothermophilus) |
PF00044(Gp_dh_N)PF02800(Gp_dh_C) | 3 | ASN O 236ASP O 312ASN O 313 | NoneNoneNAD O 336 (-4.2A) | 0.72A | 4agaA-1dbvO:undetectable | 4agaA-1dbvO:17.42 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1di4 | LYSOZYME C (Homo sapiens) |
PF00062(Lys) | 3 | ASN A 46ASP A 53ASN A 60 | None | 0.68A | 4agaA-1di4A:25.2 | 4agaA-1di4A:60.47 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1gd6 | LYSOZYME (Bombyx mori) |
PF00062(Lys) | 3 | ASN A 43ASP A 49ASN A 56 | None | 0.45A | 4agaA-1gd6A:20.0 | 4agaA-1gd6A:41.73 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1iiz | LYSOZYME (Antheraeamylitta) |
PF00062(Lys) | 3 | ASN A 44ASP A 50ASN A 57 | None | 0.44A | 4agaA-1iizA:19.5 | 4agaA-1iizA:39.06 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1jug | LYSOZYME (Tachyglossusaculeatus) |
PF00062(Lys) | 3 | ASN A 46ASP A 52ASN A 59 | None | 0.37A | 4agaA-1jugA:23.2 | 4agaA-1jugA:52.76 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1lmo | LYSOZYME (Oncorhynchusmykiss) |
PF00062(Lys) | 3 | ASN A 46ASP A 52ASN A 59 | NoneNAG A 131 ( 4.5A)NAG A 131 (-4.1A) | 0.36A | 4agaA-1lmoA:26.1 | 4agaA-1lmoA:60.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1m54 | CYSTATHIONINEBETA-SYNTHASE (Homo sapiens) |
PF00291(PALP) | 3 | ASN A 149ASP A 376ASN A 380 | PLP A1110 (-3.6A)PLP A1110 (-3.2A)None | 0.76A | 4agaA-1m54A:undetectable | 4agaA-1m54A:16.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1mio | NITROGENASEMOLYBDENUM IRONPROTEIN (BETA CHAIN) (Clostridiumpasteurianum) |
PF00148(Oxidored_nitro) | 3 | ASN B 234ASP B 231ASN B 169 | None | 0.75A | 4agaA-1mioB:undetectable | 4agaA-1mioB:14.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1obf | GLYCERALDEHYDE3-PHOSPHATEDEHYDROGENASE (Achromobacterxylosoxidans) |
PF00044(Gp_dh_N)PF02800(Gp_dh_C) | 3 | ASN O 240ASP O 315ASN O 316 | None | 0.70A | 4agaA-1obfO:undetectable | 4agaA-1obfO:16.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1q5a | EP-CADHERIN (Mus musculus) |
PF00028(Cadherin) | 3 | ASN A 434ASP A 515ASN A 518 | CA A 914 (-2.5A) CA A 914 (-3.1A)None | 0.70A | 4agaA-1q5aA:undetectable | 4agaA-1q5aA:9.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1u2x | ADP-SPECIFICPHOSPHOFRUCTOKINASE (Pyrococcushorikoshii) |
PF04587(ADP_PFK_GK) | 3 | ASN A 37ASP A 39ASN A 182 | SO4 A1003 ( 4.6A)NoneNone | 0.68A | 4agaA-1u2xA:undetectable | 4agaA-1u2xA:12.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ud3 | AMYLASE (Bacillus sp.KSM-K38) |
PF00128(Alpha-amylase)PF09154(DUF1939) | 3 | ASN A 161ASP A 194ASN A 183 | None NA A1001 (-3.3A)None | 0.75A | 4agaA-1ud3A:undetectable | 4agaA-1ud3A:15.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wve | 4-CRESOLDEHYDROGENASE[HYDROXYLATING]FLAVOPROTEIN SUBUNIT (Pseudomonasputida) |
PF01565(FAD_binding_4)PF02913(FAD-oxidase_C) | 3 | ASN A 506ASP A 516ASN A 518 | None | 0.62A | 4agaA-1wveA:undetectable | 4agaA-1wveA:12.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xd6 | GASTRODIANIN-4 (Gastrodia elata) |
PF01453(B_lectin) | 3 | ASN A 77ASP A 59ASN A 61 | None | 0.81A | 4agaA-1xd6A:undetectable | 4agaA-1xd6A:24.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1yiq | QUINOHEMOPROTEINALCOHOLDEHYDROGENASE (Pseudomonasputida) |
PF01011(PQQ)PF13360(PQQ_2)PF13442(Cytochrome_CBB3) | 3 | ASN A 247ASP A 283ASN A 167 | None | 0.42A | 4agaA-1yiqA:undetectable | 4agaA-1yiqA:11.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1z6u | NP95-LIKE RINGFINGER PROTEINISOFORM B (Homo sapiens) |
PF00097(zf-C3HC4) | 3 | ASN A 784ASP A 703ASN A 706 | None | 0.65A | 4agaA-1z6uA:undetectable | 4agaA-1z6uA:18.18 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2gv0 | LYSOZYME C (Pelodiscussinensis) |
PF00062(Lys) | 3 | ASN A 47ASP A 54ASN A 61 | None | 0.34A | 4agaA-2gv0A:25.6 | 4agaA-2gv0A:68.46 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2h5z | LYSOZYME 1 (Musca domestica) |
PF00062(Lys) | 3 | ASN A 44ASP A 50ASN A 57 | None | 0.43A | 4agaA-2h5zA:19.9 | 4agaA-2h5zA:39.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2i1y | RECEPTOR-TYPETYROSINE-PROTEINPHOSPHATASE (Homo sapiens) |
PF00102(Y_phosphatase) | 3 | ASN A 895ASP A 923ASN A 927 | None | 0.74A | 4agaA-2i1yA:undetectable | 4agaA-2i1yA:18.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2j3z | C2 TOXIN COMPONENT I (Clostridiumbotulinum) |
PF03496(ADPrib_exo_Tox) | 3 | ASN A 271ASP A 273ASN A 276 | None | 0.68A | 4agaA-2j3zA:undetectable | 4agaA-2j3zA:15.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2nz9 | BOTULINUM NEUROTOXINTYPE A (Clostridiumbotulinum) |
PF01742(Peptidase_M27)PF07951(Toxin_R_bind_C)PF07952(Toxin_trans)PF07953(Toxin_R_bind_N) | 3 | ASN A1238ASP A1246ASN A1268 | None | 0.74A | 4agaA-2nz9A:undetectable | 4agaA-2nz9A:6.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pkq | GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASEB (Spinaciaoleracea) |
PF00044(Gp_dh_N)PF02672(CP12)PF02800(Gp_dh_C) | 3 | ASN O 236ASP O 312ASN O 313 | NoneNoneNDP O 363 (-4.2A) | 0.64A | 4agaA-2pkqO:undetectable | 4agaA-2pkqO:18.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pt6 | SPERMIDINE SYNTHASE (Plasmodiumfalciparum) |
PF01564(Spermine_synth)PF17284(Spermine_synt_N) | 3 | ASN A 142ASP A 144ASN A 173 | None | 0.62A | 4agaA-2pt6A:undetectable | 4agaA-2pt6A:17.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qu7 | PUTATIVETRANSCRIPTIONALREGULATOR (Staphylococcussaprophyticus) |
PF13407(Peripla_BP_4) | 3 | ASN A 75ASP A 279ASN A 251 | None | 0.70A | 4agaA-2qu7A:undetectable | 4agaA-2qu7A:18.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2rhp | THROMBOSPONDIN-2 (Homo sapiens) |
PF02412(TSP_3)PF05735(TSP_C)PF07645(EGF_CA)PF12947(EGF_3) | 3 | ASN A 784ASP A 777ASN A 778 | CA A 21 (-3.1A) CA A 21 ( 2.4A)None | 0.79A | 4agaA-2rhpA:undetectable | 4agaA-2rhpA:13.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2rhp | THROMBOSPONDIN-2 (Homo sapiens) |
PF02412(TSP_3)PF05735(TSP_C)PF07645(EGF_CA)PF12947(EGF_3) | 3 | ASN A 881ASP A 874ASN A 875 | CA A 9 (-3.3A) CA A 9 ( 2.3A)None | 0.80A | 4agaA-2rhpA:undetectable | 4agaA-2rhpA:13.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2sxl | SEX-LETHAL PROTEIN (Drosophilamelanogaster) |
PF00076(RRM_1) | 3 | ASN A 31ASP A 51ASN A 3 | None | 0.71A | 4agaA-2sxlA:undetectable | 4agaA-2sxlA:20.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wan | PULLULANASE (Bacillusacidopullulyticus) |
PF00128(Alpha-amylase)PF02922(CBM_48) | 3 | ASN A 287ASP A 289ASN A 299 | None | 0.78A | 4agaA-2wanA:undetectable | 4agaA-2wanA:9.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wtb | FATTY ACIDMULTIFUNCTIONALPROTEIN (ATMFP2) (Arabidopsisthaliana) |
PF00378(ECH_1)PF00725(3HCDH)PF02737(3HCDH_N) | 3 | ASN A 492ASP A 431ASN A 433 | None | 0.63A | 4agaA-2wtbA:undetectable | 4agaA-2wtbA:10.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xf8 | D-ERYTHROSE-4-PHOSPHATE DEHYDROGENASE (Escherichiacoli) |
PF00044(Gp_dh_N)PF02800(Gp_dh_C) | 3 | ASN A 236ASP A 312ASN A 313 | None | 0.69A | 4agaA-2xf8A:undetectable | 4agaA-2xf8A:17.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2z4t | BETA-GALACTOSIDEALPHA-2,6-SIALYLTRANSFERASE (Photobacteriumsp. JT-ISH-224) |
PF11477(PM0188) | 3 | ASN A 226ASP A 228ASN A 289 | GOL A3002 (-4.3A)NoneGOL A3002 (-3.3A) | 0.79A | 4agaA-2z4tA:undetectable | 4agaA-2z4tA:12.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3aqi | FERROCHELATASE (Homo sapiens) |
PF00762(Ferrochelatase) | 3 | ASN A 408ASP A 97ASN A 204 | None | 0.77A | 4agaA-3aqiA:undetectable | 4agaA-3aqiA:15.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3cb7 | LYS-RICH LYSOZYME 2 (Musca domestica) |
PF00062(Lys) | 3 | ASN A 48ASP A 54ASN A 61 | ASN A 48 ( 0.6A)ASP A 54 (-0.5A)ASN A 61 (-0.6A) | 0.39A | 4agaA-3cb7A:19.0 | 4agaA-3cb7A:37.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ctp | PERIPLASMIC BINDINGPROTEIN/LACITRANSCRIPTIONALREGULATOR (Alkaliphilusmetalliredigens) |
PF13377(Peripla_BP_3) | 3 | ASN A 239ASP A 213ASN A 72 | XLF A 401 (-3.8A)XLF A 401 ( 4.3A)XLF A 401 (-3.0A) | 0.75A | 4agaA-3ctpA:undetectable | 4agaA-3ctpA:17.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3doc | GLYCERALDEHYDE3-PHOSPHATEDEHYDROGENASE (Brucellaabortus) |
PF00044(Gp_dh_N)PF02800(Gp_dh_C) | 3 | ASN A 239ASP A 315ASN A 316 | NoneNoneNAD A 901 (-3.9A) | 0.72A | 4agaA-3docA:undetectable | 4agaA-3docA:15.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3e38 | TWO-DOMAIN PROTEINCONTAINING PREDICTEDPHP-LIKEMETAL-DEPENDENTPHOSPHOESTERASE (Bacteroidesvulgatus) |
PF16392(DUF5001) | 3 | ASN A 91ASP A 130ASN A 132 | NoneNoneGOL A 9 ( 4.9A) | 0.67A | 4agaA-3e38A:undetectable | 4agaA-3e38A:15.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3e38 | TWO-DOMAIN PROTEINCONTAINING PREDICTEDPHP-LIKEMETAL-DEPENDENTPHOSPHOESTERASE (Bacteroidesvulgatus) |
PF16392(DUF5001) | 3 | ASN A 132ASP A 89ASN A 91 | GOL A 9 ( 4.9A)NoneNone | 0.72A | 4agaA-3e38A:undetectable | 4agaA-3e38A:15.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fby | CARTILAGE OLIGOMERICMATRIX PROTEIN (Homo sapiens) |
PF02412(TSP_3)PF05735(TSP_C) | 3 | ASN A 415ASP A 408ASN A 409 | CA A 814 (-3.2A) CA A 814 ( 2.5A)None | 0.71A | 4agaA-3fbyA:undetectable | 4agaA-3fbyA:11.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fby | CARTILAGE OLIGOMERICMATRIX PROTEIN (Homo sapiens) |
PF02412(TSP_3)PF05735(TSP_C) | 3 | ASN A 489ASP A 482ASN A 483 | CA A 823 (-3.1A) CA A 823 ( 2.8A)None | 0.73A | 4agaA-3fbyA:undetectable | 4agaA-3fbyA:11.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fl2 | E3 UBIQUITIN-PROTEINLIGASE UHRF1 (Homo sapiens) |
no annotation | 3 | ASN A 775ASP A 687ASN A 690 | None | 0.65A | 4agaA-3fl2A:undetectable | 4agaA-3fl2A:15.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gnq | GLYCERALDEHYDE-3-PHOSPHATEDEHYDROGENASE, TYPEI (Burkholderiapseudomallei) |
PF00044(Gp_dh_N)PF02800(Gp_dh_C) | 3 | ASN A 240ASP A 315ASN A 316 | None | 0.72A | 4agaA-3gnqA:undetectable | 4agaA-3gnqA:15.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3i1c | DIISOPROPYL-FLUOROPHOSPHATASE (Loligo vulgaris) |
PF08450(SGL) | 3 | ASN A 83ASP A 26ASN A 28 | None | 0.68A | 4agaA-3i1cA:undetectable | 4agaA-3i1cA:17.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3i2n | WD REPEAT-CONTAININGPROTEIN 92 (Homo sapiens) |
PF00400(WD40) | 3 | ASN A 189ASP A 191ASN A 207 | None | 0.52A | 4agaA-3i2nA:undetectable | 4agaA-3i2nA:15.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3k2b | GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASEA, CHLOROPLASTIC (Arabidopsisthaliana) |
PF00044(Gp_dh_N)PF02800(Gp_dh_C) | 3 | ASN A 236ASP A 312ASN A 313 | NoneNoneNAD A 335 (-3.9A) | 0.76A | 4agaA-3k2bA:undetectable | 4agaA-3k2bA:17.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3l0d | GLYCERALDEHYDE3-PHOSPHATEDEHYDROGENASE (Bartonellahenselae) |
PF00044(Gp_dh_N)PF02800(Gp_dh_C) | 3 | ASN A 239ASP A 315ASN A 316 | NoneNoneNAD A 336 (-3.9A) | 0.71A | 4agaA-3l0dA:undetectable | 4agaA-3l0dA:16.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pc3 | CG1753, ISOFORM A (Drosophilamelanogaster) |
PF00291(PALP)PF00571(CBS) | 3 | ASN A 118ASP A 345ASN A 349 | P1T A 702 (-3.8A)P1T A 702 (-3.3A)None | 0.71A | 4agaA-3pc3A:undetectable | 4agaA-3pc3A:14.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3q2v | CADHERIN-1 (Mus musculus) |
PF00028(Cadherin) | 3 | ASN A 435ASP A 517ASN A 518 | CA A 612 (-2.8A) CA A 612 (-3.2A)None | 0.64A | 4agaA-3q2vA:undetectable | 4agaA-3q2vA:12.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rhg | PUTATIVEPHOPHOTRIESTERASE (Proteusmirabilis) |
PF02126(PTE) | 3 | ASN A 191ASP A 147ASN A 151 | None | 0.57A | 4agaA-3rhgA:undetectable | 4agaA-3rhgA:14.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3u1w | HYPOTHETICALPERIPLASMIC PROTEIN (Parabacteroidesdistasonis) |
PF11396(PepSY_like) | 3 | ASN A 177ASP A 196ASN A 197 | None | 0.49A | 4agaA-3u1wA:undetectable | 4agaA-3u1wA:18.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3uy4 | PANTOTHENATESYNTHETASE (Campylobacterjejuni) |
PF02569(Pantoate_ligase) | 3 | ASN A 258ASP A 245ASN A 247 | None | 0.58A | 4agaA-3uy4A:undetectable | 4agaA-3uy4A:17.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vv3 | DESEASIN MCP-01 (Pseudoalteromonassp. SM9913) |
PF00082(Peptidase_S8) | 3 | ASN A 80ASP A 85ASN A 66 | CA A 401 (-3.1A) CA A 401 (-3.0A)None | 0.71A | 4agaA-3vv3A:undetectable | 4agaA-3vv3A:15.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3zdf | GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE (Thermosynechococcuselongatus) |
PF00044(Gp_dh_N)PF02800(Gp_dh_C) | 3 | ASN A 240ASP A 316ASN A 317 | NoneNoneNAD A1001 (-3.7A) | 0.79A | 4agaA-3zdfA:undetectable | 4agaA-3zdfA:18.10 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3zvq | LYSOZYME C (Gallus gallus) |
PF00062(Lys) | 3 | ASN A 46ASP A 52ASN A 59 | None | 0.31A | 4agaA-3zvqA:10.6 | 4agaA-3zvqA:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4aay | AROB (Rhizobium sp.NT-26) |
PF00355(Rieske) | 3 | ASN B 155ASP B 157ASN B 56 | None | 0.75A | 4agaA-4aayB:undetectable | 4agaA-4aayB:21.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4cak | INTEGRIN BETA-3 (Homo sapiens) |
PF00362(Integrin_beta)PF07965(Integrin_B_tail)PF07974(EGF_2)PF17205(PSI_integrin) | 3 | ASN B 3ASP B 39ASN B 43 | None | 0.78A | 4agaA-4cakB:undetectable | 4agaA-4cakB:10.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4dib | GLYCERALDEHYDE3-PHOSPHATEDEHYDROGENASE (Bacillusanthracis) |
PF00044(Gp_dh_N)PF02800(Gp_dh_C) | 3 | ASN A 237ASP A 313ASN A 314 | None | 0.72A | 4agaA-4dibA:undetectable | 4agaA-4dibA:16.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4eg9 | UNCHARACTERIZEDPROTEINSAOUHSC_02783 (Staphylococcusaureus) |
PF04507(DUF576) | 3 | ASN A 41ASP A 167ASN A 169 | None | 0.68A | 4agaA-4eg9A:undetectable | 4agaA-4eg9A:17.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ej6 | PUTATIVEZINC-BINDINGDEHYDROGENASE (Sinorhizobiummeliloti) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 3 | ASN A 289ASP A 83ASN A 85 | NoneEDO A 401 (-3.8A)None | 0.64A | 4agaA-4ej6A:undetectable | 4agaA-4ej6A:17.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4igb | LPXTG CELL WALLSURFACE PROTEIN (Streptococcusgordonii) |
no annotation | 3 | ASN D 293ASP D 198ASN D 135 | None | 0.52A | 4agaA-4igbD:undetectable | 4agaA-4igbD:12.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kyz | DESIGNED PROTEINOR327 (syntheticconstruct) |
no annotation | 3 | ASN A 16ASP A 18ASN A 9 | None | 0.79A | 4agaA-4kyzA:undetectable | 4agaA-4kyzA:17.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4l27 | CYSTATHIONINEBETA-SYNTHASE (Homo sapiens) |
no annotation | 3 | ASN B 149ASP B 376ASN B 380 | PLP B 601 (-3.5A)PLP B 601 (-3.1A)None | 0.80A | 4agaA-4l27B:undetectable | 4agaA-4l27B:14.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lsm | GLYCERALDEHYDE3-PHOSPHATEDEHYDROGENASE,CYTOSOLIC (Trypanosomacruzi) |
PF00044(Gp_dh_N)PF02800(Gp_dh_C) | 3 | ASN A 243ASP A 319ASN A 320 | NoneNoneNAD A 401 (-3.7A) | 0.74A | 4agaA-4lsmA:undetectable | 4agaA-4lsmA:20.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lvo | SUBTILISIN-LIKESERINE PROTEASE (Plasmodiumfalciparum) |
PF00082(Peptidase_S8) | 3 | ASN A 404ASP A 409ASN A 389 | CA A 703 (-2.8A) CA A 703 (-2.8A)None | 0.80A | 4agaA-4lvoA:undetectable | 4agaA-4lvoA:15.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4m7s | BTRN (Bacilluscirculans) |
PF13186(SPASM) | 3 | ASN A 17ASP A 94ASN A 92 | NoneNoneSF4 A 502 (-4.5A) | 0.76A | 4agaA-4m7sA:undetectable | 4agaA-4m7sA:14.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4n78 | CYTOPLASMICFMR1-INTERACTINGPROTEIN 1 (Homo sapiens) |
PF05994(FragX_IP)PF07159(DUF1394) | 3 | ASN A 176ASP A 172ASN A 218 | None | 0.80A | 4agaA-4n78A:undetectable | 4agaA-4n78A:7.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4o59 | GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE (Bos taurus) |
PF00044(Gp_dh_N)PF02800(Gp_dh_C) | 3 | ASN O 236ASP O 312ASN O 313 | NoneNoneNAD O 401 (-3.8A) | 0.75A | 4agaA-4o59O:undetectable | 4agaA-4o59O:18.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4p8r | GLYCERALDEHYDE3-PHOSPHATEDEHYDROGENASE,CYTOSOLIC (Trypanosomabrucei) |
PF00044(Gp_dh_N)PF02800(Gp_dh_C) | 3 | ASN A 237ASP A 313ASN A 314 | NoneNoneNAD A 400 (-3.7A) | 0.74A | 4agaA-4p8rA:undetectable | 4agaA-4p8rA:17.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qn9 | N-ACYL-PHOSPHATIDYLETHANOLAMINE-HYDROLYZING PHOSPHOLIPASE D (Homo sapiens) |
PF12706(Lactamase_B_2) | 3 | ASN A 388ASP A 302ASN A 277 | None | 0.80A | 4agaA-4qn9A:undetectable | 4agaA-4qn9A:17.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4r12 | PUTATIVEUNCHARACTERIZEDPROTEIN (Dictyosteliumpurpureum) |
PF05450(Nicastrin) | 3 | ASN A 427ASP A 435ASN A 439 | None | 0.44A | 4agaA-4r12A:undetectable | 4agaA-4r12A:12.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4tr2 | SUBTILISIN-LIKE 1SERINE PROTEASE (Plasmodiumvivax) |
PF00082(Peptidase_S8) | 3 | ASN A 333ASP A 346ASN A 348 | CA A 803 ( 4.9A) CA A 803 (-3.2A) CA A 803 (-2.8A) | 0.79A | 4agaA-4tr2A:undetectable | 4agaA-4tr2A:11.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4tr2 | SUBTILISIN-LIKE 1SERINE PROTEASE (Plasmodiumvivax) |
PF00082(Peptidase_S8) | 3 | ASN A 348ASP A 353ASN A 333 | CA A 803 (-2.8A) CA A 803 (-3.1A) CA A 803 ( 4.9A) | 0.65A | 4agaA-4tr2A:undetectable | 4agaA-4tr2A:11.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4txw | HYALURONOGLUCOSAMINIDASE (Clostridiumperfringens) |
PF00754(F5_F8_type_C) | 3 | ASN A 100ASP A 92ASN A 88 | NoneNone CA A 202 (-3.2A) | 0.79A | 4agaA-4txwA:undetectable | 4agaA-4txwA:20.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4u1r | ATP-DEPENDENT6-PHOSPHOFRUCTOKINASE, PLATELET TYPE (Homo sapiens) |
PF00365(PFK) | 3 | ASN A 259ASP A 235ASN A 267 | NonePO4 A 802 ( 4.6A)None | 0.66A | 4agaA-4u1rA:undetectable | 4agaA-4u1rA:10.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4uoe | SPERMIDINE SYNTHASE (Plasmodiumfalciparum) |
PF01564(Spermine_synth)PF17284(Spermine_synt_N) | 3 | ASN A 142ASP A 144ASN A 173 | None | 0.64A | 4agaA-4uoeA:undetectable | 4agaA-4uoeA:17.15 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4wg1 | LYSOZYME C (Gallus gallus) |
PF00062(Lys) | 3 | ASN A 46ASP A 52ASN A 59 | None | 0.19A | 4agaA-4wg1A:28.3 | 4agaA-4wg1A:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xed | PEPTIDASE M14,CARBOXYPEPTIDASE A (Thermoplasmatalesarchaeon SCGCAB-540-F20) |
PF00801(PKD) | 3 | ASN A 1ASP A 33ASN A 31 | CA A 101 (-2.9A) CA A 101 (-3.3A) CA A 101 (-3.5A) | 0.80A | 4agaA-4xedA:undetectable | 4agaA-4xedA:22.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zw0 | 3-HYDROXYACYL-[ACYL-CARRIER-PROTEIN]DEHYDRATASE FABZ (CandidatusLiberibacterasiaticus) |
PF07977(FabA) | 3 | ASN A 84ASP A 37ASN A 121 | None | 0.78A | 4agaA-4zw0A:undetectable | 4agaA-4zw0A:19.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5anb | EUKARYOTICTRANSLATIONINITIATION FACTOR 6 (Dictyosteliumdiscoideum) |
PF01912(eIF-6) | 3 | ASN I 156ASP I 112ASN I 21 | None | 0.77A | 4agaA-5anbI:undetectable | 4agaA-5anbI:21.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5c7i | GLYCERALDEHYDE-3-PHOSPHATEDEHYDROGENASE,TESTIS-SPECIFIC (Mus musculus) |
PF00044(Gp_dh_N)PF02800(Gp_dh_C) | 3 | ASN O 343ASP O 419ASN O 420 | None | 0.75A | 4agaA-5c7iO:undetectable | 4agaA-5c7iO:19.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fn4 | NICASTRIN (Homo sapiens) |
PF05450(Nicastrin) | 3 | ASN A 450ASP A 458ASN A 462 | None | 0.52A | 4agaA-5fn4A:undetectable | 4agaA-5fn4A:11.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fq6 | SUSC/RAGA FAMILYTONB-LINKED OUTERMEMBRANE PROTEIN (Bacteroidesthetaiotaomicron) |
PF00593(TonB_dep_Rec)PF07715(Plug) | 3 | ASN B 84ASP B 59ASN B 131 | None | 0.78A | 4agaA-5fq6B:undetectable | 4agaA-5fq6B:9.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fq6 | SUSC/RAGA FAMILYTONB-LINKED OUTERMEMBRANE PROTEIN (Bacteroidesthetaiotaomicron) |
PF00593(TonB_dep_Rec)PF07715(Plug) | 3 | ASN B 458ASP B 460ASN B 481 | None | 0.67A | 4agaA-5fq6B:undetectable | 4agaA-5fq6B:9.36 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5jen | LYSOZYME C (Gallus gallus) |
PF00062(Lys) | 3 | ASN B 46ASP B 52ASN B 59 | None NA A 401 (-3.1A)None | 0.55A | 4agaA-5jenB:26.6 | 4agaA-5jenB:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5k59 | UNCHARACTERIZEDLEUKOCIDIN-LIKEPROTEIN 2 (Staphylococcusaureus) |
no annotation | 3 | ASN D 196ASP D 197ASN D 206 | None | 0.80A | 4agaA-5k59D:undetectable | 4agaA-5k59D:16.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5kkg | ANCMT E72A (syntheticconstruct) |
PF04587(ADP_PFK_GK) | 3 | ASN A 16ASP A 18ASN A 161 | None | 0.79A | 4agaA-5kkgA:undetectable | 4agaA-5kkgA:14.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5m11 | IMMUNOREACTIVE 84KDANTIGEN PG93 (Porphyromonasgingivalis) |
no annotation | 3 | ASN A 617ASP A 557ASN A 559 | PG4 A 815 ( 4.8A)NoneNone | 0.77A | 4agaA-5m11A:undetectable | 4agaA-5m11A:9.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5m5p | PRE-MRNA-SPLICINGHELICASE BRR2 (Saccharomycescerevisiae) |
PF00270(DEAD)PF00271(Helicase_C)PF02889(Sec63) | 3 | ASN A1713ASP A1678ASN A1579 | None | 0.80A | 4agaA-5m5pA:undetectable | 4agaA-5m5pA:5.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5moy | BOTULINUM NEUROTOXINTYPE A (Clostridiumbotulinum) |
PF07951(Toxin_R_bind_C)PF07953(Toxin_R_bind_N) | 3 | ASN A1238ASP A1246ASN A1268 | None | 0.61A | 4agaA-5moyA:undetectable | 4agaA-5moyA:15.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mpd | 26S PROTEASOMEREGULATORY SUBUNITRPN326S PROTEASOMEREGULATORY SUBUNITRPN8 (Saccharomycescerevisiae;Saccharomycescerevisiae) |
PF01399(PCI)PF08375(Rpn3_C)PF01398(JAB)PF13012(MitMem_reg) | 3 | ASN U 294ASP U 290ASN S 490 | None | 0.62A | 4agaA-5mpdU:undetectable | 4agaA-5mpdU:14.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5n6r | BREAKPOINT CLUSTERREGION PROTEIN (Homo sapiens) |
no annotation | 3 | ASN A 637ASP A 629ASN A 627 | None | 0.70A | 4agaA-5n6rA:undetectable | 4agaA-5n6rA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5tpc | BOTULINUM NEUROTOXINTYPE A (Clostridiumbotulinum) |
PF07951(Toxin_R_bind_C)PF07953(Toxin_R_bind_N) | 3 | ASN A1238ASP A1246ASN A1268 | None | 0.75A | 4agaA-5tpcA:undetectable | 4agaA-5tpcA:15.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5tro | PENICILLIN-BINDINGPROTEIN 1 (Staphylococcusaureus) |
PF00905(Transpeptidase)PF03717(PBP_dimer) | 3 | ASN A 72ASP A 245ASN A 247 | None | 0.71A | 4agaA-5troA:undetectable | 4agaA-5troA:13.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5uz8 | CADHERIN-23 (Mus musculus) |
no annotation | 3 | ASN A2373ASP A2456ASN A2457 | CA A2608 (-3.1A) CA A2608 (-3.2A)None | 0.76A | 4agaA-5uz8A:undetectable | 4agaA-5uz8A:undetectable | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5v8g | LYSOZYME ISOFORM I (Anasplatyrhynchos) |
no annotation | 3 | ASN A 46ASP A 52ASN A 59 | None | 0.27A | 4agaA-5v8gA:27.0 | 4agaA-5v8gA:84.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5x8z | PENICILLIN VACYLASE-LIKE PROTEIN (Shewanellaloihica) |
no annotation | 3 | ASN A 285ASP A 287ASN A 302 | None | 0.68A | 4agaA-5x8zA:undetectable | 4agaA-5x8zA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5y28 | - (-) |
no annotation | 3 | ASN A 256ASP A 165ASN A 167 | None | 0.64A | 4agaA-5y28A:undetectable | 4agaA-5y28A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6c8z | ADP-DEPENDENTPHOSPHOFRUCTOKINASE (Methanosarcinales) |
no annotation | 3 | ASN A 34ASP A 36ASN A 181 | None | 0.79A | 4agaA-6c8zA:undetectable | 4agaA-6c8zA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6chs | PUTATIVE CELLDIVISION CONTROLPROTEIN (Chaetomiumthermophilum) |
no annotation | 3 | ASN H 367ASP H 578ASN H 575 | None | 0.74A | 4agaA-6chsH:undetectable | 4agaA-6chsH:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6fay | ODZ3 PROTEIN (Mus musculus) |
no annotation | 3 | ASN A1371ASP A1308ASN A1310 | None | 0.73A | 4agaA-6fayA:undetectable | 4agaA-6fayA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6fpe | TRNA N6-ADENOSINETHREONYLCARBAMOYLTRANSFERASE (Thermotogamaritima) |
no annotation | 3 | ASN B 27ASP B 296ASN B 297 | None | 0.81A | 4agaA-6fpeB:undetectable | 4agaA-6fpeB:undetectable |