SIMILAR PATTERNS OF AMINO ACIDS FOR 4AF0_A_MOAA1526

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1brw PROTEIN (PYRIMIDINE
NUCLEOSIDE
PHOSPHORYLASE)

(Geobacillus
stearothermophilus) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N)
PF07831
(PYNP_C) 		4 ASP A 122
ARG A 365
GLY A 152
GLN A 153
 None
 0.89A 4af0A-1brwA:
undetectable		 4af0A-1brwA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dnp DNA PHOTOLYASE

(Escherichia
coli) 		PF00875
(DNA_photolyase)
PF03441
(FAD_binding_7) 		4 ASP A 130
SER A 131
ARG A 249
GLY A 245
 None
 0.88A 4af0A-1dnpA:
undetectable		 4af0A-1dnpA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dqc TACHYCITIN

(Tachypleus
tridentatus) 		PF01607
(CBM_14) 		4 SER A  23
SER A  26
ASN A  20
GLY A  43
 None
NH2  A  74 ( 4.4A)
None
None
 1.01A 4af0A-1dqcA:
undetectable		 4af0A-1dqcA:
6.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gze MONO-ADP-RIBOSYLTRAN
SFERASE C3

(Clostridium
botulinum) 		PF03496
(ADPrib_exo_Tox) 		4 SER A 181
ASN A 179
MET A 178
GLY A 211
 None
 1.03A 4af0A-1gzeA:
undetectable		 4af0A-1gzeA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gzg DELTA-AMINOLEVULINIC
ACID DEHYDRATASE

(Pseudomonas
aeruginosa) 		PF00490
(ALAD) 		4 SER A 309
ARG A 315
GLY A 262
GLN A 284
 None
 1.02A 4af0A-1gzgA:
11.0		 4af0A-1gzgA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ieh BRUC.D4.4

(Lama glama) 		PF07686
(V-set) 		4 SER A  25
ASN A  77
GLY A 108
GLN A   5
 None
 1.02A 4af0A-1iehA:
undetectable		 4af0A-1iehA:
14.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1jcn INOSINE
MONOPHOSPHATE
DEHYDROGENASE I

(Homo sapiens) 		PF00478
(IMPDH)
PF00571
(CBS) 		6 ASP A 274
SER A 275
SER A 276
ASN A 303
ARG A 322
MET A 325
 None
None
None
CPR  A 631 ( 4.5A)
CPR  A 631 (-4.0A)
None
 0.19A 4af0A-1jcnA:
48.6		 4af0A-1jcnA:
56.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1jr1 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2

(Cricetulus
griseus) 		PF00478
(IMPDH)
PF00571
(CBS) 		5 ASP A 274
ASN A 303
ARG A 322
MET A 325
GLY A 413
 MOA  A1332 (-3.5A)
MOA  A1332 (-3.7A)
MOA  A1332 (-3.6A)
None
IMP  A1331 (-3.5A)
 0.95A 4af0A-1jr1A:
57.1		 4af0A-1jr1A:
56.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1jr1 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2

(Cricetulus
griseus) 		PF00478
(IMPDH)
PF00571
(CBS) 		8 ASP A 274
SER A 275
SER A 276
ASN A 303
ARG A 322
MET A 325
GLY A 415
GLN A 441
 MOA  A1332 (-3.5A)
None
MOA  A1332 (-2.6A)
MOA  A1332 (-3.7A)
MOA  A1332 (-3.6A)
None
IMP  A1331 ( 3.1A)
MOA  A1332 ( 3.8A)
 0.52A 4af0A-1jr1A:
57.1		 4af0A-1jr1A:
56.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1jr1 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2

(Cricetulus
griseus) 		PF00478
(IMPDH)
PF00571
(CBS) 		5 SER A 276
ASN A 303
MET A 325
GLY A 442
GLN A 441
 MOA  A1332 (-2.6A)
MOA  A1332 (-3.7A)
None
IMP  A1331 (-3.0A)
MOA  A1332 ( 3.8A)
 1.09A 4af0A-1jr1A:
57.1		 4af0A-1jr1A:
56.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lrt INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Tritrichomonas
suis) 		PF00478
(IMPDH) 		5 ASP A 261
SER A 262
SER A 263
ASN A 291
GLY A 409
 TAD  A 901 (-2.3A)
TAD  A 901 ( 2.6A)
TAD  A 901 (-2.7A)
IMP  A 801 ( 4.6A)
IMP  A 801 ( 3.2A)
 0.42A 4af0A-1lrtA:
45.3		 4af0A-1lrtA:
27.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1mew INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Tritrichomonas
suis) 		PF00478
(IMPDH)
PF00571
(CBS) 		5 ASP A 261
SER A 262
SER A 263
ASN A 291
GLY A 409
 NAD  A 987 (-2.5A)
NAD  A 987 (-2.7A)
NAD  A 987 (-3.1A)
XMP  A 602 ( 4.4A)
XMP  A 602 ( 3.1A)
 0.44A 4af0A-1mewA:
46.9		 4af0A-1mewA:
33.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nl3 PREPROTEIN
TRANSLOCASE SECA 1
SUBUNIT

(Mycobacterium
tuberculosis) 		PF01043
(SecA_PP_bind)
PF07516
(SecA_SW)
PF07517
(SecA_DEAD) 		4 SER A 285
ASN A 284
ARG A 777
GLY A 828
 None
 0.90A 4af0A-1nl3A:
undetectable		 4af0A-1nl3A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1poj ISOASPARTYL
DIPEPTIDASE

(Escherichia
coli) 		PF01979
(Amidohydro_1) 		4 ASP A 167
SER A 205
ARG A 233
GLY A 297
 None
None
AE1  A 401 (-2.8A)
None
 1.02A 4af0A-1pojA:
6.1		 4af0A-1pojA:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rc9 CYSTEINE-RICH
SECRETORY PROTEIN

(Trimeresurus
stejnegeri) 		PF00188
(CAP)
PF08562
(Crisp) 		4 SER A  62
SER A  61
GLY A  74
GLN A 146
 None
 0.81A 4af0A-1rc9A:
undetectable		 4af0A-1rc9A:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rt8 FIMBRIN

(Schizosaccharomyces
pombe) 		PF00307
(CH) 		4 ASP A 293
ASN A 296
ARG A 282
GLY A 347
 None
 0.97A 4af0A-1rt8A:
undetectable		 4af0A-1rt8A:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v7v CHITOBIOSE
PHOSPHORYLASE

(Vibrio
proteolyticus) 		PF06165
(Glyco_transf_36)
PF17167
(Glyco_hydro_36) 		4 SER A 235
ASN A 236
GLY A 232
GLN A 231
 None
 0.94A 4af0A-1v7vA:
undetectable		 4af0A-1v7vA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w07 ACYL-COA OXIDASE

(Arabidopsis
thaliana) 		PF01756
(ACOX)
PF02770
(Acyl-CoA_dh_M)
PF14749
(Acyl-CoA_ox_N) 		4 SER A 236
ASN A 235
ARG A  58
GLY A 177
 None
None
None
FAD  A1660 (-4.1A)
 0.92A 4af0A-1w07A:
undetectable		 4af0A-1w07A:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wvr TRIFLIN

(Protobothrops
flavoviridis) 		PF00188
(CAP)
PF08562
(Crisp) 		4 SER A  62
SER A  61
GLY A  74
GLN A 146
 None
 0.77A 4af0A-1wvrA:
undetectable		 4af0A-1wvrA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yt8 THIOSULFATE
SULFURTRANSFERASE

(Pseudomonas
aeruginosa) 		PF00581
(Rhodanese) 		4 SER A 199
ASN A 192
GLY A 308
GLN A 312
 None
None
None
SO3  A 540 ( 3.8A)
 0.98A 4af0A-1yt8A:
undetectable		 4af0A-1yt8A:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2co7 SAFA PILUS SUBUNIT

(Salmonella
enterica) 		PF09460
(Saf-Nte_pilin) 		4 SER A  51
ASN A  50
GLY A 141
GLN A 143
 None
 0.89A 4af0A-2co7A:
undetectable		 4af0A-2co7A:
12.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d0v METHANOL
DEHYDROGENASE LARGE
SUBUNIT

(Hyphomicrobium
denitrificans) 		PF01011
(PQQ)
PF13360
(PQQ_2) 		4 SER A  69
SER A  70
ASN A 108
GLY A 536
 None
 0.88A 4af0A-2d0vA:
undetectable		 4af0A-2d0vA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fon PEROXISOMAL ACYL-COA
OXIDASE 1A

(Solanum
lycopersicum) 		PF01756
(ACOX)
PF02770
(Acyl-CoA_dh_M)
PF14749
(Acyl-CoA_ox_N) 		4 SER A 236
ASN A 235
ARG A  58
GLY A 177
 None
None
None
FAD  A1000 (-4.4A)
 1.03A 4af0A-2fonA:
undetectable		 4af0A-2fonA:
24.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gn4 UDP-GLCNAC C6
DEHYDRATASE

(Helicobacter
pylori) 		PF02719
(Polysacc_synt_2) 		4 SER A 316
SER A 317
ASN A 320
GLY A 172
 None
None
None
UD1  A 335 ( 4.0A)
 0.87A 4af0A-2gn4A:
undetectable		 4af0A-2gn4A:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hke DIPHOSPHOMEVALONATE
DECARBOXYLASE,
PUTATIVE

(Trypanosoma
brucei) 		PF00288
(GHMP_kinases_N) 		4 SER A 198
SER A 199
MET A 203
GLY A 295
 None
None
SO4  A 381 ( 4.8A)
None
 1.03A 4af0A-2hkeA:
undetectable		 4af0A-2hkeA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k0d COLICIN-E7 IMMUNITY
PROTEIN

(Escherichia
coli) 		PF01320
(Colicin_Pyocin) 		4 ASP X   9
SER X   8
GLY X  94
GLN X  93
 None
 0.88A 4af0A-2k0dX:
undetectable		 4af0A-2k0dX:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pyj DNA POLYMERASE

(Bacillus virus
phi29) 		PF03175
(DNA_pol_B_2) 		4 ASP A 219
SER A 395
ASN A 396
GLY A 430
 None
 0.90A 4af0A-2pyjA:
undetectable		 4af0A-2pyjA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vp1 PERIPLASMIC
IRON-BINDING PROTEIN

(Synechocystis
sp. PCC 6803) 		PF13343
(SBP_bac_6) 		4 ASP A 335
SER A 336
ARG A 338
GLY A 182
 None
 1.00A 4af0A-2vp1A:
undetectable		 4af0A-2vp1A:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vsg VARIANT SURFACE
GLYCOPROTEIN ILTAT
1.24

(Trypanosoma
brucei) 		PF00913
(Trypan_glycop) 		5 SER A  33
ASN A  32
MET A  29
GLY A 256
GLN A 255
 None
 1.34A 4af0A-2vsgA:
undetectable		 4af0A-2vsgA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wmh FUCOLECTIN-RELATED
PROTEIN

(Streptococcus
pneumoniae) 		PF08306
(Glyco_hydro_98M)
PF08307
(Glyco_hydro_98C) 		4 ASP A 226
ARG A 225
GLY A 359
GLN A 362
 None
 0.89A 4af0A-2wmhA:
10.8		 4af0A-2wmhA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wyh ALPHA-MANNOSIDASE

(Streptococcus
pyogenes) 		PF01074
(Glyco_hydro_38)
PF07748
(Glyco_hydro_38C)
PF09261
(Alpha-mann_mid) 		4 SER A 181
ASN A 180
GLY A 131
GLN A 132
 None
 0.86A 4af0A-2wyhA:
undetectable		 4af0A-2wyhA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y7i STM4351

(Salmonella
enterica) 		PF00497
(SBP_bac_3) 		4 SER A  77
ARG A 213
GLY A  28
GLN A  69
 None
 0.97A 4af0A-2y7iA:
undetectable		 4af0A-2y7iA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zpa UNCHARACTERIZED
PROTEIN YPFI

(Escherichia
coli) 		PF05127
(Helicase_RecD)
PF08351
(DUF1726)
PF13718
(GNAT_acetyltr_2)
PF17176
(tRNA_bind_3) 		4 ASP A 551
SER A 594
ARG A 600
GLY A 445
 None
 0.94A 4af0A-2zpaA:
undetectable		 4af0A-2zpaA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3alx HEMAGGLUTININ,LINKER
,CDW150

(Measles
morbillivirus;
Saguinus
oedipus;
synthetic
construct) 		PF00423
(HN)
PF06214
(SLAM) 		4 ASP A 304
SER A 352
SER A 353
GLN A 567
 None
 0.98A 4af0A-3alxA:
undetectable		 4af0A-3alxA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3be7 ZN-DEPENDENT
ARGININE
CARBOXYPEPTIDASE

(unidentified) 		PF01979
(Amidohydro_1) 		4 SER A 285
ASN A 287
ARG A 290
GLY A 280
 None
 1.00A 4af0A-3be7A:
6.2		 4af0A-3be7A:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ils AFLATOXIN
BIOSYNTHESIS
POLYKETIDE SYNTHASE

(Aspergillus
parasiticus) 		PF00975
(Thioesterase) 		4 ASP A1890
SER A1889
GLY A1859
GLN A1858
 None
 0.96A 4af0A-3ilsA:
undetectable		 4af0A-3ilsA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ing HOMOSERINE
DEHYDROGENASE

(Thermoplasma
acidophilum) 		PF00742
(Homoserine_dh)
PF03447
(NAD_binding_3) 		4 SER A 171
SER A 172
ASN A 175
GLY A 147
 None
 1.01A 4af0A-3ingA:
undetectable		 4af0A-3ingA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kf8 PROTEIN STN1

(Candida
tropicalis) 		PF10451
(Stn1) 		4 SER A  52
SER A 121
ASN A  55
GLY A  89
 None
 0.93A 4af0A-3kf8A:
undetectable		 4af0A-3kf8A:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mc6 SPHINGOSINE-1-PHOSPH
ATE LYASE

(Saccharomyces
cerevisiae) 		PF00282
(Pyridoxal_deC) 		4 ASP C 342
SER C 343
MET C 392
GLY C 235
 None
None
None
PO4  C   1 (-3.1A)
 0.98A 4af0A-3mc6C:
undetectable		 4af0A-3mc6C:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rjt LIPOLYTIC PROTEIN
G-D-S-L FAMILY

(Alicyclobacillus
acidocaldarius) 		PF13472
(Lipase_GDSL_2) 		4 SER A  61
ASN A  63
ARG A  71
GLY A  19
 ACT  A 301 ( 4.3A)
None
None
CSO  A  18 ( 2.4A)
 0.98A 4af0A-3rjtA:
undetectable		 4af0A-3rjtA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t8s INOSITOL
1,4,5-TRISPHOSPHATE
RECEPTOR TYPE 1

(Rattus
norvegicus) 		PF01365
(RYDR_ITPR)
PF02815
(MIR)
PF08709
(Ins145_P3_rec) 		4 SER A 277
SER A 278
ARG A 241
GLN A 513
 None
 0.77A 4af0A-3t8sA:
undetectable		 4af0A-3t8sA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tac LIPRIN-ALPHA-2

(Homo sapiens) 		PF00536
(SAM_1)
PF07647
(SAM_2) 		4 SER B1109
SER B1031
ASN B1110
GLY B1077
 SO4  B   1 (-2.3A)
None
None
None
 0.98A 4af0A-3tacB:
undetectable		 4af0A-3tacB:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tad LIPRIN-ALPHA-2

(Homo sapiens) 		PF00536
(SAM_1)
PF07647
(SAM_2) 		4 SER A1109
SER A1031
ASN A1110
GLY A1077
 None
 1.00A 4af0A-3tadA:
undetectable		 4af0A-3tadA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ti8 NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		4 ASP A 460
SER A 441
SER A 440
GLY A 109
 None
 0.82A 4af0A-3ti8A:
undetectable		 4af0A-3ti8A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ubm FORMYL-COA:OXALATE
COA-TRANSFERASE

(Acetobacter
aceti) 		PF02515
(CoA_transf_3) 		4 ASP A  62
ASN A  53
ARG A  56
GLY A 408
 None
 0.89A 4af0A-3ubmA:
undetectable		 4af0A-3ubmA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vsm OCCLUSION-DERIVED
VIRUS ENVELOPE
PROTEIN E66

(Autographa
californica
multiple
nucleopolyhedrovirus) 		PF04850
(Baculo_E66) 		4 ASP A 397
SER A 396
ASN A 401
GLY A 347
 None
 0.96A 4af0A-3vsmA:
undetectable		 4af0A-3vsmA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wx7 CHITIN
OLIGOSACCHARIDE
DEACETYLASE

(Vibrio
parahaemolyticus) 		PF01522
(Polysacc_deac_1) 		4 ASN A 330
MET A 328
GLY A 351
GLN A 221
 None
None
CA  A 901 (-3.9A)
None
 0.97A 4af0A-3wx7A:
3.3		 4af0A-3wx7A:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wzf ASPARTATE
AMINOTRANSFERASE,
CYTOPLASMIC

(Homo sapiens) 		PF00155
(Aminotran_1_2) 		4 SER A 255
SER A 257
ASN A 259
GLY A 302
 None
 1.00A 4af0A-3wzfA:
undetectable		 4af0A-3wzfA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zq4 RIBONUCLEASE J 1

(Bacillus
subtilis) 		PF00753
(Lactamase_B)
PF07521
(RMMBL) 		4 ASP A 146
SER A 147
ARG A 139
GLY A  96
 None
 1.02A 4af0A-3zq4A:
undetectable		 4af0A-3zq4A:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zyt ESTERASE A

(Paenarthrobacter
nitroguajacolicus) 		PF00144
(Beta-lactamase) 		4 SER A 244
SER A 243
GLY A 188
GLN A 170
 None
 0.93A 4af0A-3zytA:
undetectable		 4af0A-3zytA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4azc BETA-N-ACETYLHEXOSAM
INIDASE

(Streptococcus
pneumoniae) 		PF00728
(Glyco_hydro_20) 		4 ASP A 804
SER A 739
MET A 770
GLY A 669
 NGW  A2042 (-3.6A)
None
None
None
 1.01A 4af0A-4azcA:
4.7		 4af0A-4azcA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b56 ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 1

(Mus musculus) 		PF01033
(Somatomedin_B)
PF01223
(Endonuclease_NS)
PF01663
(Phosphodiest) 		4 SER A 690
ASN A 691
GLY A 719
GLN A 751
 None
 0.92A 4af0A-4b56A:
undetectable		 4af0A-4b56A:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4blq P4

(Pseudomonas
phage phi8) 		PF11602
(NTPase_P4) 		4 ASP A 171
ASN A 121
ARG A 280
GLY A 114
 None
 1.02A 4af0A-4blqA:
undetectable		 4af0A-4blqA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dw2 FAB FRAGMENT OF
PRO-UPA ANTIBODY
MAB-112

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 SER H  30
ASN H  73
ARG H  71
GLY H  26
 None
 1.02A 4af0A-4dw2H:
undetectable		 4af0A-4dw2H:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e9l ATTACHING AND
EFFACING PROTEIN,
PATHOGENESIS FACTOR

(Escherichia
coli) 		PF09134
(Invasin_D3) 		4 SER A 933
SER A 970
GLY A 967
GLN A 968
 None
 1.00A 4af0A-4e9lA:
undetectable		 4af0A-4e9lA:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fek PUTATIVE DIFLAVIN
FLAVOPROTEIN A 5

(Nostoc sp. PCC
7120) 		no annotation 4 SER A  43
ASN A  44
ARG A  22
GLY A  40
 None
 0.99A 4af0A-4fekA:
undetectable		 4af0A-4fekA:
16.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4fxs INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Vibrio cholerae) 		PF00478
(IMPDH)
PF00571
(CBS) 		4 SER A 251
SER A 252
ASN A 279
GLY A 391
 MOA  A 702 (-3.7A)
MOA  A 702 (-2.8A)
MOA  A 702 (-3.5A)
IMP  A 701 (-3.2A)
 0.50A 4af0A-4fxsA:
51.3		 4af0A-4fxsA:
37.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ix2 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Vibrio cholerae) 		PF00478
(IMPDH) 		4 ASP A 250
SER A 251
SER A 252
ASN A 279
 None
None
None
IMP  A 501 ( 4.4A)
 0.74A 4af0A-4ix2A:
45.8		 4af0A-4ix2A:
31.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mju NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		4 ASP A 460
SER A 441
SER A 440
GLY A 109
 None
 0.77A 4af0A-4mjuA:
undetectable		 4af0A-4mjuA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nzy PROBABLE THYMIDYLATE
KINASE

(Sulfurisphaera
tokodaii) 		PF02223
(Thymidylate_kin) 		4 ASP A  13
ASN A  40
ARG A  93
GLY A 152
 EDO  A 310 ( 4.5A)
PEG  A 304 ( 4.9A)
EDO  A 310 (-3.5A)
None
 1.03A 4af0A-4nzyA:
undetectable		 4af0A-4nzyA:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o9x TCDB2, TCCC3

(Photorhabdus
luminescens) 		PF03534
(SpvB)
PF12255
(TcdB_toxin_midC)
PF12256
(TcdB_toxin_midN) 		4 ASP A 297
SER A 302
ASN A 303
GLY A 315
 None
 1.01A 4af0A-4o9xA:
undetectable		 4af0A-4o9xA:
13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p1x GAMMA-HEMOLYSIN
COMPONENT C

(Staphylococcus
aureus) 		PF07968
(Leukocidin) 		4 SER B 162
ASN B 141
GLY B 168
GLN B 169
 None
 0.99A 4af0A-4p1xB:
undetectable		 4af0A-4p1xB:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pbv PROTEIN-TYROSINE
PHOSPHATASE
CRYPALPHA1 ISOFORM

(Gallus gallus) 		PF07679
(I-set)
PF13927
(Ig_3) 		4 SER C 209
ASN C 210
GLY C  43
GLN C  41
 None
 0.92A 4af0A-4pbvC:
undetectable		 4af0A-4pbvC:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r1s CINNAMOYL COA
REDUCTASE

(Petunia x
hybrida) 		PF01370
(Epimerase) 		4 SER A 123
ASN A 183
ARG A 243
GLY A 160
 NAP  A 401 ( 3.1A)
None
None
None
 0.90A 4af0A-4r1sA:
undetectable		 4af0A-4r1sA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r1u CINNAMOYL COA
REDUCTASE

(Medicago
truncatula) 		PF01370
(Epimerase) 		4 SER A 118
ASN A 178
ARG A 238
GLY A 155
 None
 1.03A 4af0A-4r1uA:
undetectable		 4af0A-4r1uA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uoe SPERMIDINE SYNTHASE

(Plasmodium
falciparum) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		4 ASP A 196
SER A 197
SER A 198
GLN A  72
 4ZY  A 501 ( 3.6A)
None
MTA  A 401 (-3.3A)
MTA  A 401 (-3.3A)
 0.80A 4af0A-4uoeA:
undetectable		 4af0A-4uoeA:
19.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xwu INOSINE-5'-MONOPHOSP
HATE
DEHYDROGENASE,INOSIN
E-5'-MONOPHOSPHATE
DEHYDROGENASE

(Eremothecium
gossypii) 		PF00478
(IMPDH) 		6 ASP A 277
SER A 278
SER A 279
ASN A 306
ARG A 325
MET A 328
 None
 0.14A 4af0A-4xwuA:
49.2		 4af0A-4xwuA:
53.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yfg RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE DELTA

(Mus musculus) 		no annotation 4 SER B 198
ARG B 181
GLY B 204
GLN B 203
 None
 1.02A 4af0A-4yfgB:
undetectable		 4af0A-4yfgB:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yok PUTATIVE FLAGELLAR
PROTEIN FLIS

(Parabacteroides
merdae) 		PF12866
(DUF3823) 		4 ASP A 168
ASN A 171
GLY A  49
GLN A  75
 None
None
GOL  A 302 (-4.6A)
None
 0.96A 4af0A-4yokA:
undetectable		 4af0A-4yokA:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z38 MLNA

(Bacillus
velezensis) 		no annotation 4 SER A 354
SER A 353
MET A 348
GLY A 398
 None
None
FMN  A 900 (-3.6A)
None
 0.98A 4af0A-4z38A:
21.0		 4af0A-4z38A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z7y DIPHOSPHOMEVALONATE
DECARBOXYLASE

(Sulfolobus
solfataricus) 		PF00288
(GHMP_kinases_N) 		4 SER A 193
SER A 194
MET A 198
GLY A 283
 None
 0.98A 4af0A-4z7yA:
undetectable		 4af0A-4z7yA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zgv FERREDOXIN RECEPTOR

(Pectobacterium
atrosepticum) 		PF07715
(Plug) 		4 ASP A 207
SER A 209
GLY A 265
GLN A 258
 None
 0.88A 4af0A-4zgvA:
undetectable		 4af0A-4zgvA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b1h CYSTATHIONINE
BETA-SYNTHASE

(Lactobacillus
plantarum) 		PF00291
(PALP) 		4 ASP A 290
SER A 291
SER A 292
GLY A 265
 LLP  A  42 ( 3.2A)
None
None
None
 0.83A 4af0A-5b1hA:
undetectable		 4af0A-5b1hA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cef ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE

(Cryptococcus
neoformans) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		4 SER A 110
SER A  87
ASN A 111
GLY A  10
 None
 1.00A 4af0A-5cefA:
undetectable		 4af0A-5cefA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cvc SERINE RACEMASE

(Zea mays) 		PF00291
(PALP) 		4 SER A 164
ASN A 163
GLY A 200
GLN A 171
 None
 0.69A 4af0A-5cvcA:
undetectable		 4af0A-5cvcA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dm7 50S RIBOSOMAL
PROTEIN L32

(Deinococcus
radiodurans) 		PF01783
(Ribosomal_L32p) 		4 SER Z  12
SER Z  14
ARG Z  16
MET Z  18
 U  X2004 ( 2.5A)
G  X  16 ( 3.2A)
C  X 527 ( 3.3A)
C  X2028 ( 3.8A)
 0.99A 4af0A-5dm7Z:
undetectable		 4af0A-5dm7Z:
6.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fsb TECTONIN 2

(Laccaria
bicolor) 		no annotation 4 ASP A 125
SER A  89
ARG A  87
GLY A 205
 MG  A 299 ( 3.9A)
None
None
None
 0.98A 4af0A-5fsbA:
undetectable		 4af0A-5fsbA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gs0 TOLL-LIKE RECEPTOR 3

(Homo sapiens) 		PF13516
(LRR_6)
PF13855
(LRR_8) 		4 ASP A 366
SER A 389
ASN A 388
GLY A 369
 None
 1.03A 4af0A-5gs0A:
undetectable		 4af0A-5gs0A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gsz KINESIN-LIKE PROTEIN
KIF19

(Mus musculus) 		PF00225
(Kinesin) 		4 ASP A 250
ASN A 203
ARG A 206
GLY A 109
 MG  A 402 ( 3.9A)
None
MG  A 402 ( 4.3A)
ADP  A 401 (-3.1A)
 0.93A 4af0A-5gszA:
undetectable		 4af0A-5gszA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hvo ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
(UDP-FORMING)

(Aspergillus
fumigatus) 		PF00982
(Glyco_transf_20) 		4 ASP A 205
SER A 478
ARG A 240
GLY A 143
 None
 0.83A 4af0A-5hvoA:
undetectable		 4af0A-5hvoA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hx0 UNCHARACTERIZED
PROTEIN DFER_1899

(Dyadobacter
fermentans) 		PF13088
(BNR_2) 		4 SER A  93
ASN A  92
GLY A 140
GLN A 122
 None
None
None
ACT  A 402 (-4.1A)
 0.99A 4af0A-5hx0A:
undetectable		 4af0A-5hx0A:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ie9 NUCLEOTIDE
PYROPHOSPHOHYDROLASE

(Bacillus cereus) 		PF03819
(MazG) 		4 ASP A  14
SER A  80
ASN A  82
GLY A  23
 None
 0.99A 4af0A-5ie9A:
undetectable		 4af0A-5ie9A:
11.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ixq RECEPTOR-LIKE
PROTEIN KINASE 5

(Arabidopsis
thaliana) 		PF08263
(LRRNT_2)
PF13855
(LRR_8) 		4 SER A  74
SER A  73
ASN A  99
GLY A  58
 NAG  A 701 (-3.5A)
None
None
None
 0.91A 4af0A-5ixqA:
undetectable		 4af0A-5ixqA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k8g ANTIFREEZE PROTEIN

(Marinomonas
primoryensis) 		no annotation 4 SER A 441
SER A 442
ASN A 443
GLN A 489
 None
 0.82A 4af0A-5k8gA:
undetectable		 4af0A-5k8gA:
24.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l46 DIMETHYLGLYCINE
DEHYDROGENASE,
MITOCHONDRIAL

(Homo sapiens) 		PF01266
(DAO)
PF01571
(GCV_T)
PF08669
(GCV_T_C)
PF16350
(FAO_M) 		4 ASN A 716
MET A 715
GLY A 485
GLN A 492
 None
 0.98A 4af0A-5l46A:
undetectable		 4af0A-5l46A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mwr TETR FAMILY
TRANSCRIPTIONAL
REGULATOR

(Sulfolobus
acidocaldarius) 		no annotation 4 SER A 175
SER A 173
ASN A 174
GLY A 166
 None
 1.00A 4af0A-5mwrA:
undetectable		 4af0A-5mwrA:
9.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mzs FERRIC ENTEROBACTIN
RECEPTOR

(Pseudomonas
aeruginosa) 		no annotation 4 ASP A 108
SER A 109
ASN A  71
GLN A 258
 None
 0.93A 4af0A-5mzsA:
undetectable		 4af0A-5mzsA:
10.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mzs FERRIC ENTEROBACTIN
RECEPTOR

(Pseudomonas
aeruginosa) 		no annotation 4 SER A 109
ASN A  71
GLY A 259
GLN A 258
 None
 0.78A 4af0A-5mzsA:
undetectable		 4af0A-5mzsA:
10.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ofn DNA PRIMASE SMALL
SUBUNIT PRIS

(Sulfolobus
solfataricus) 		no annotation 4 ASP A  97
SER A  96
ARG A  36
GLY A 186
 None
 0.84A 4af0A-5ofnA:
undetectable		 4af0A-5ofnA:
10.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5tc3 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Eremothecium
gossypii) 		PF00478
(IMPDH)
PF00571
(CBS) 		7 ASP A 277
SER A 278
SER A 279
ASN A 306
ARG A 325
MET A 328
GLN A 448
 None
None
None
5GP  A 600 (-3.2A)
5GP  A 600 (-3.1A)
None
None
 0.31A 4af0A-5tc3A:
56.5		 4af0A-5tc3A:
64.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5tc3 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Eremothecium
gossypii) 		PF00478
(IMPDH)
PF00571
(CBS) 		7 ASP A 277
SER A 278
SER A 279
ASN A 306
ARG A 325
MET A 328
GLY A 418
 None
None
None
5GP  A 600 (-3.2A)
5GP  A 600 (-3.1A)
None
5GP  A 600 (-3.1A)
 0.44A 4af0A-5tc3A:
56.5		 4af0A-5tc3A:
64.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5tc3 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Eremothecium
gossypii) 		PF00478
(IMPDH)
PF00571
(CBS) 		5 SER A 279
ASN A 306
MET A 328
GLY A 449
GLN A 448
 None
5GP  A 600 (-3.2A)
None
5GP  A 600 ( 3.8A)
None
 1.15A 4af0A-5tc3A:
56.5		 4af0A-5tc3A:
64.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tqm CINNAMOYL-COA
REDUCTASE

(Sorghum bicolor) 		PF01370
(Epimerase) 		4 SER A 149
ASN A 209
ARG A 269
GLY A 186
 DTT  A 403 ( 2.6A)
None
None
None
 0.99A 4af0A-5tqmA:
undetectable		 4af0A-5tqmA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x68 KYNURENINE
3-MONOOXYGENASE

(Homo sapiens) 		no annotation 4 ASP A 332
SER A 335
ASN A 336
ARG A  30
 None
 0.94A 4af0A-5x68A:
undetectable		 4af0A-5x68A:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bka NITRONATE
MONOOXYGENASE

(Cyberlindnera
mrakii) 		no annotation 4 ASP A 208
ASN A 297
GLY A 191
GLN A 190
 None
None
None
FMN  A 401 (-3.9A)
 0.98A 4af0A-6bkaA:
6.8		 4af0A-6bkaA:
9.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c2j RNAP1
RNAP2

(Escherichia
virus N4) 		no annotation 4 SER B 246
ASN B 242
ARG A 238
GLY B  80
 None
 1.02A 4af0A-6c2jB:
undetectable		 4af0A-6c2jB:
10.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f3d INTERLEUKIN-1
RECEPTOR-ASSOCIATED
KINASE 4

(Homo sapiens) 		no annotation 4 ASP A 272
ARG A 273
MET A 265
GLY A 193
 CJT  A 502 (-3.3A)
None
CJT  A 502 (-4.9A)
CJT  A 502 ( 3.9A)
 1.02A 4af0A-6f3dA:
undetectable		 4af0A-6f3dA:
10.21