SIMILAR PATTERNS OF AMINO ACIDS FOR 4AE1_A_NCAA1536
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1aip | ELONGATION FACTOR TS (Thermusthermophilus) |
PF00889(EF_TS) | 4 | GLY C 145TYR C 150ALA C 143GLU C 121 | None | 0.98A | 4ae1A-1aipC:undetectable | 4ae1A-1aipC:16.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ap2 | MONOCLONAL ANTIBODYC219 (Mus musculus) |
PF07686(V-set) | 4 | GLY A 105TYR A 92ALA A 106TYR A 93 | None | 1.00A | 4ae1A-1ap2A:3.4 | 4ae1A-1ap2A:11.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1dab | P.69 PERTACTIN (Bordetellapertussis) |
PF03212(Pertactin) | 4 | GLY A 337TYR A 342ALA A 304GLU A 311 | None | 0.99A | 4ae1A-1dabA:undetectable | 4ae1A-1dabA:24.25 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1dtp | DIPHTHERIA TOXIN (Corynephagebeta) |
PF02763(Diphtheria_C) | 6 | HIS A 21GLY A 22TYR A 54ALA A 62TYR A 65GLU A 148 | APU A 200 ( 3.3A)APU A 200 ( 4.0A)APU A 200 ( 4.0A)APU A 200 ( 4.7A)APU A 200 ( 3.6A)None | 0.50A | 4ae1A-1dtpA:24.3 | 4ae1A-1dtpA:99.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ebl | BETA-KETOACYL-ACPSYNTHASE III (Escherichiacoli) |
PF08541(ACP_syn_III_C)PF08545(ACP_syn_III) | 4 | GLY A 9TYR A 11ALA A 62GLU A 57 | None | 0.95A | 4ae1A-1eblA:undetectable | 4ae1A-1eblA:23.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1efy | POLY (ADP-RIBOSE)POLYMERASE (Gallus gallus) |
PF00644(PARP)PF02877(PARP_reg) | 5 | HIS A 862GLY A 863TYR A 896TYR A 907GLU A 988 | BZC A 201 (-4.0A)BZC A 201 (-3.9A)BZC A 201 (-4.0A)BZC A 201 (-3.6A)BZC A 201 (-4.0A) | 0.43A | 4ae1A-1efyA:6.4 | 4ae1A-1efyA:21.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ikp | EXOTOXIN A (Pseudomonasaeruginosa) |
PF09009(Exotox-A_cataly)PF09101(Exotox-A_bind)PF09102(Exotox-A_target) | 6 | HIS A 440GLY A 441TYR A 470ALA A 478TYR A 481GLU A 553 | None | 0.48A | 4ae1A-1ikpA:9.1 | 4ae1A-1ikpA:22.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1jgu | ANTIBODY HEAVY CHAIN (Mus musculus) |
PF07654(C1-set)PF07686(V-set) | 4 | GLY H 104TYR H 90ALA H 105TYR H 91 | None | 0.93A | 4ae1A-1jguH:3.8 | 4ae1A-1jguH:19.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1k7y | METHIONINE SYNTHASE (Escherichiacoli) |
PF02310(B12-binding)PF02607(B12-binding_2)PF02965(Met_synt_B12) | 4 | GLY A1059TYR A1111ALA A1060TYR A1181 | NoneSO4 A 267 (-4.8A)NoneNone | 0.99A | 4ae1A-1k7yA:undetectable | 4ae1A-1k7yA:23.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1m33 | BIOH PROTEIN (Escherichiacoli) |
PF00561(Abhydrolase_1) | 4 | GLY A 204TYR A 228ALA A 106TYR A 203 | None | 0.95A | 4ae1A-1m33A:undetectable | 4ae1A-1m33A:20.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1mor | GLUCOSAMINE6-PHOSPHATE SYNTHASE (Escherichiacoli) |
PF01380(SIS) | 4 | GLY A 471TYR A 497ALA A 479TYR A 476 | None | 0.94A | 4ae1A-1morA:undetectable | 4ae1A-1morA:20.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1olp | ALPHA-TOXIN (Clostridiumsardiniense) |
PF00882(Zn_dep_PLPC)PF01477(PLAT) | 4 | HIS A 136TYR A 65ALA A 94TYR A 127 | ZN A1374 (-3.4A)NoneNoneNone | 0.97A | 4ae1A-1olpA:undetectable | 4ae1A-1olpA:20.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1pix | GLUTACONYL-COADECARBOXYLASE ASUBUNIT (Acidaminococcusfermentans) |
PF01039(Carboxyl_trans) | 4 | GLY A 378TYR A 371ALA A 377GLU A 373 | None | 0.64A | 4ae1A-1pixA:undetectable | 4ae1A-1pixA:22.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qok | MFE-23 RECOMBINANTANTIBODY FRAGMENT (Mus musculus) |
PF07686(V-set) | 4 | GLY A 259TYR A 246ALA A 260TYR A 247 | None | 0.99A | 4ae1A-1qokA:3.9 | 4ae1A-1qokA:21.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1r3n | BETA-ALANINESYNTHASE (Lachanceakluyveri) |
PF01546(Peptidase_M20)PF07687(M20_dimer) | 4 | HIS A 323GLY A 294ALA A 289GLU A 335 | None | 0.96A | 4ae1A-1r3nA:undetectable | 4ae1A-1r3nA:23.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1sb8 | WBPP (Pseudomonasaeruginosa) |
PF01370(Epimerase) | 4 | HIS A 53GLY A 52ALA A 25GLU A 59 | NoneNAD A 342 (-2.9A)NAD A 342 (-4.2A)None | 0.74A | 4ae1A-1sb8A:undetectable | 4ae1A-1sb8A:20.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ua7 | ALPHA-AMYLASE (Bacillussubtilis) |
PF00128(Alpha-amylase) | 4 | GLY A 207TYR A 223ALA A 178TYR A 220 | None | 0.98A | 4ae1A-1ua7A:undetectable | 4ae1A-1ua7A:23.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vft | ALANINE RACEMASE (Streptomyceslavendulae) |
PF00842(Ala_racemase_C)PF01168(Ala_racemase_N) | 4 | HIS A 44GLY A 43ALA A 41TYR A 42 | NoneNoneNoneDCS A 401 (-4.6A) | 0.99A | 4ae1A-1vftA:undetectable | 4ae1A-1vftA:21.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1y56 | HYPOTHETICAL PROTEINPH1363 (Pyrococcushorikoshii) |
PF07992(Pyr_redox_2)PF13510(Fer2_4) | 4 | GLY A 367ALA A 368TYR A 369GLU A 384 | None | 0.99A | 4ae1A-1y56A:undetectable | 4ae1A-1y56A:21.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1yce | SUBUNIT C (Ilyobactertartaricus) |
PF00137(ATP-synt_C) | 4 | GLY A 33ALA A 35TYR A 34GLU A 41 | None | 0.97A | 4ae1A-1yceA:undetectable | 4ae1A-1yceA:10.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ap2 | SINGLE CHAIN FV (Mus musculus) |
PF07686(V-set) | 4 | GLY A 105TYR A 92ALA A 106TYR A 93 | None | 1.00A | 4ae1A-2ap2A:3.0 | 4ae1A-2ap2A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2d9c | SIGNAL-REGULATORYPROTEIN BETA-1 (Homo sapiens) |
PF07686(V-set) | 4 | GLY A 112TYR A 94ALA A 113TYR A 95 | None | 0.85A | 4ae1A-2d9cA:4.0 | 4ae1A-2d9cA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2evr | COG0791: CELLWALL-ASSOCIATEDHYDROLASES(INVASION-ASSOCIATEDPROTEINS) (Nostocpunctiforme) |
PF00877(NLPC_P60) | 4 | GLY A 163TYR A 186ALA A 162TYR A 180 | None | 1.00A | 4ae1A-2evrA:undetectable | 4ae1A-2evrA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ho5 | OXIDOREDUCTASE,GFO/IDH/MOCA FAMILY (Streptococcuspneumoniae) |
PF01408(GFO_IDH_MocA) | 4 | GLY A 227TYR A 181ALA A 148GLU A 251 | None | 0.99A | 4ae1A-2ho5A:undetectable | 4ae1A-2ho5A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hw2 | RIFAMPIN ADP-RIBOSYLTRANSFERASE (Mycolicibacteriumsmegmatis) |
PF12120(Arr-ms) | 4 | HIS A 19GLY A 20TYR A 49ALA A 57 | NoneNoneGLY A 144 (-3.8A)None | 0.55A | 4ae1A-2hw2A:4.2 | 4ae1A-2hw2A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2jjv | SIGNAL-REGULATORYPROTEIN BETA 1. (Homo sapiens) |
PF07686(V-set) | 4 | GLY A 107TYR A 89ALA A 108TYR A 90 | None | 1.00A | 4ae1A-2jjvA:3.9 | 4ae1A-2jjvA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pqf | POLY [ADP-RIBOSE]POLYMERASE 12 (Homo sapiens) |
PF00644(PARP) | 4 | HIS A 564GLY A 565TYR A 596TYR A 607 | GAB A 701 ( 3.7A)GAB A 701 (-3.6A)GAB A 701 (-4.5A)GAB A 701 (-3.3A) | 0.39A | 4ae1A-2pqfA:6.3 | 4ae1A-2pqfA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qdd | MANDELATERACEMASE/MUCONATELACTONIZING ENZYME (Roseovariusnubinhibens) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 4 | GLY A 46TYR A 35ALA A 108GLU A 49 | None | 0.96A | 4ae1A-2qddA:undetectable | 4ae1A-2qddA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qkb | RIBONUCLEASE H1 (Homo sapiens) |
PF00075(RNase_H) | 4 | GLY A 161TYR A 163ALA A 277GLU A 272 | None | 0.92A | 4ae1A-2qkbA:undetectable | 4ae1A-2qkbA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qty | POLY(ADP-RIBOSE)GLYCOHYDROLASE ARH3 (Mus musculus) |
PF03747(ADP_ribosyl_GH) | 4 | HIS A 166GLY A 137TYR A 133ALA A 175 | None | 0.88A | 4ae1A-2qtyA:undetectable | 4ae1A-2qtyA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qua | EXTRACELLULAR LIPASE (Serratiamarcescens) |
no annotation | 4 | GLY A 111ALA A 119TYR A 110GLU A 122 | None | 0.95A | 4ae1A-2quaA:undetectable | 4ae1A-2quaA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2rfg | DIHYDRODIPICOLINATESYNTHASE (Hahellachejuensis) |
PF00701(DHDPS) | 4 | GLY A 104ALA A 103TYR A 105GLU A 83 | None | 0.96A | 4ae1A-2rfgA:undetectable | 4ae1A-2rfgA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vc2 | INTEGRIN ALPHA-IIB (Homo sapiens) |
PF01839(FG-GAP)PF13517(VCBS) | 4 | GLY A 381TYR A 353ALA A 378GLU A 324 | None | 0.76A | 4ae1A-2vc2A:undetectable | 4ae1A-2vc2A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2w9m | POLYMERASE X (Deinococcusradiodurans) |
PF14520(HHH_5)PF14716(HHH_8) | 4 | GLY A 166TYR A 228ALA A 165GLU A 229 | None | 0.94A | 4ae1A-2w9mA:undetectable | 4ae1A-2w9mA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xn8 | PUTATIVE CYTOCHROMEP450 125 (Mycobacteriumtuberculosis) |
PF00067(p450) | 4 | GLY A 222ALA A 224TYR A 223GLU A 230 | None | 0.87A | 4ae1A-2xn8A:undetectable | 4ae1A-2xn8A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3aeh | HEMOGLOBIN-BINDINGPROTEASE HBPAUTOTRANSPORTER (Escherichiacoli) |
PF03797(Autotransporter) | 4 | GLY A1253ALA A1228TYR A1227GLU A1249 | None | 0.86A | 4ae1A-3aehA:undetectable | 4ae1A-3aehA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3b78 | EXOTOXIN A (Pseudomonasaeruginosa) |
PF09009(Exotox-A_cataly) | 6 | HIS B 440GLY B 441TYR B 470ALA B 478TYR B 481GLU B 553 | NAD B 700 (-3.9A)NAD B 700 (-3.9A)NAD B 700 (-3.9A)NAD B 700 (-3.6A)NAD B 700 (-3.4A)NAD B 700 (-3.5A) | 0.49A | 4ae1A-3b78B:9.4 | 4ae1A-3b78B:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3c3v | ARACHIN ARAH3ISOFORM (Arachishypogaea) |
PF00190(Cupin_1) | 4 | HIS A 445GLY A 444ALA A 419GLU A 440 | None | 0.92A | 4ae1A-3c3vA:2.9 | 4ae1A-3c3vA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3c49 | POLY(ADP-RIBOSE)POLYMERASE 3 (Homo sapiens) |
PF00644(PARP)PF02877(PARP_reg) | 5 | HIS A 384GLY A 385TYR A 414TYR A 425GLU A 514 | KU8 A 601 (-4.0A)KU8 A 601 (-3.5A)KU8 A 601 (-4.1A)KU8 A 601 (-3.5A)KU8 A 601 (-3.9A) | 0.49A | 4ae1A-3c49A:6.3 | 4ae1A-3c49A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dsm | UNCHARACTERIZEDPROTEIN BACUNI_02894 (Bacteroidesuniformis) |
no annotation | 4 | GLY A 57TYR A 49ALA A 31GLU A 46 | None | 0.99A | 4ae1A-3dsmA:undetectable | 4ae1A-3dsmA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gwe | 3-OXOACYL-(ACYL-CARRIER-PROTEIN)SYNTHASE III (Burkholderiapseudomallei) |
PF08541(ACP_syn_III_C)PF08545(ACP_syn_III) | 4 | GLY A 194ALA A 197TYR A 335GLU A 238 | None | 0.98A | 4ae1A-3gweA:undetectable | 4ae1A-3gweA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3h7v | O-SUCCINYLBENZOATESYNTHASE (Thermosynechococcuselongatus) |
PF13378(MR_MLE_C) | 4 | GLY A 41TYR A 30ALA A 92GLU A 44 | None | 0.97A | 4ae1A-3h7vA:undetectable | 4ae1A-3h7vA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hi0 | PUTATIVEEXOPOLYPHOSPHATASE (Agrobacteriumfabrum) |
PF02541(Ppx-GppA) | 4 | GLY A 439ALA A 406TYR A 409GLU A 433 | None | 0.97A | 4ae1A-3hi0A:undetectable | 4ae1A-3hi0A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hkv | POLY [ADP-RIBOSE]POLYMERASE 10 (Homo sapiens) |
PF00644(PARP) | 4 | HIS A 887GLY A 888TYR A 919TYR A 932 | 3AB A1025 (-3.8A)3AB A1025 (-3.5A)3AB A1025 (-4.4A)3AB A1025 (-3.7A) | 0.29A | 4ae1A-3hkvA:6.2 | 4ae1A-3hkvA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hmc | PUTATIVE PROPHAGELAMBDABA04, GLYCOSYLHYDROLASE, FAMILY 25 (Bacillusanthracis) |
PF01183(Glyco_hydro_25) | 4 | TYR A 124ALA A 62TYR A 61GLU A 95 | MES A 400 (-3.6A)NoneMES A 400 (-4.0A)MES A 400 (-3.5A) | 0.87A | 4ae1A-3hmcA:undetectable | 4ae1A-3hmcA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3il3 | 3-OXOACYL-[ACYL-CARRIER-PROTEIN]SYNTHASE 3 (Haemophilusinfluenzae) |
PF08541(ACP_syn_III_C)PF08545(ACP_syn_III) | 4 | GLY A 9TYR A 11ALA A 62GLU A 57 | None | 0.92A | 4ae1A-3il3A:undetectable | 4ae1A-3il3A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3il7 | 3-OXOACYL-[ACYL-CARRIER-PROTEIN]SYNTHASE 3 (Staphylococcusaureus) |
PF08541(ACP_syn_III_C)PF08545(ACP_syn_III) | 4 | GLY A 9TYR A 11ALA A 62GLU A 57 | None | 0.98A | 4ae1A-3il7A:undetectable | 4ae1A-3il7A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3iy7 | FRAGMENT FROMNEUTRALIZINGANTIBODY F (LIGHTCHAIN) (Rattusnorvegicus) |
PF07686(V-set) | 4 | GLY A 96TYR A 84ALA A 97TYR A 85 | None | 0.98A | 4ae1A-3iy7A:2.8 | 4ae1A-3iy7A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3jb9 | PRE-MRNA-SPLICINGFACTOR SPP42 (Schizosaccharomycespombe) |
PF08082(PRO8NT)PF08083(PROCN)PF10596(U6-snRNA_bdg)PF10597(U5_2-snRNA_bdg)PF10598(RRM_4)PF12134(PRP8_domainIV) | 4 | HIS A 602GLY A 651TYR A 603ALA A 598 | None | 0.87A | 4ae1A-3jb9A:undetectable | 4ae1A-3jb9A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ki6 | CHOLIX TOXIN (Vibrio cholerae) |
PF09009(Exotox-A_cataly) | 6 | HIS A 460GLY A 461TYR A 493ALA A 501TYR A 504GLU A 581 | G9L A 1 (-3.9A)G9L A 1 (-3.7A)G9L A 1 (-4.5A)G9L A 1 (-3.4A)G9L A 1 (-3.5A)G9L A 1 (-4.6A) | 0.55A | 4ae1A-3ki6A:8.8 | 4ae1A-3ki6A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mn1 | PROBABLE YRBI FAMILYPHOSPHATASE (Pseudomonassavastanoi) |
PF08282(Hydrolase_3) | 4 | HIS A 145GLY A 130ALA A 112GLU A 109 | None | 0.94A | 4ae1A-3mn1A:undetectable | 4ae1A-3mn1A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3p30 | 1281 FAB LIGHT CHAIN (Homo sapiens) |
PF07654(C1-set)PF07686(V-set) | 4 | GLY L 99TYR L 86ALA L 100TYR L 87 | None | 1.00A | 4ae1A-3p30L:undetectable | 4ae1A-3p30L:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3q9o | EXOTOXIN A (Vibrio cholerae) |
PF09009(Exotox-A_cataly)PF09101(Exotox-A_bind)PF09102(Exotox-A_target) | 6 | HIS A 460GLY A 461TYR A 493ALA A 501TYR A 504GLU A 581 | NAD A 700 (-3.8A)NAD A 700 (-3.7A)NAD A 700 ( 3.7A)NAD A 700 (-3.5A)NAD A 700 (-3.4A)NAD A 700 (-3.2A) | 0.55A | 4ae1A-3q9oA:9.7 | 4ae1A-3q9oA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qfk | UNCHARACTERIZEDPROTEIN (Staphylococcusaureus) |
PF00149(Metallophos)PF02872(5_nucleotid_C) | 4 | GLY A 142TYR A 175ALA A 183GLU A 178 | None | 0.97A | 4ae1A-3qfkA:undetectable | 4ae1A-3qfkA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ro2 | G-PROTEIN-SIGNALINGMODULATOR 2 (Mus musculus) |
PF13176(TPR_7)PF13424(TPR_12) | 4 | GLY A 242ALA A 244TYR A 245GLU A 219 | None | 0.99A | 4ae1A-3ro2A:2.6 | 4ae1A-3ro2A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ro3 | G-PROTEIN-SIGNALINGMODULATOR 2 (Mus musculus) |
PF13424(TPR_12) | 4 | GLY A 242ALA A 244TYR A 245GLU A 219 | None | 0.96A | 4ae1A-3ro3A:undetectable | 4ae1A-3ro3A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ruc | WBGU (Plesiomonasshigelloides) |
PF01370(Epimerase) | 4 | HIS A 53GLY A 52ALA A 25GLU A 59 | NoneNAD A 343 (-3.0A)NAD A 343 (-4.3A)None | 0.76A | 4ae1A-3rucA:undetectable | 4ae1A-3rucA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3t94 | 5'-METHYLTHIOADENOSINE PHOSPHORYLASE(MTAP) (Sulfolobussolfataricus) |
PF01048(PNP_UDP_1) | 4 | GLY A 37ALA A 74TYR A 36GLU A 119 | None | 0.92A | 4ae1A-3t94A:undetectable | 4ae1A-3t94A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tqp | ENOLASE (Coxiellaburnetii) |
PF00113(Enolase_C)PF03952(Enolase_N) | 4 | GLY A 360ALA A 333TYR A 359GLU A 304 | None | 0.78A | 4ae1A-3tqpA:2.4 | 4ae1A-3tqpA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ve2 | TRANSFERRIN-BINDINGPROTEIN 2 (Neisseriameningitidis) |
PF01298(TbpB_B_D)PF17483(TbpB_C)PF17484(TbpB_A) | 4 | HIS A 129ALA A 344TYR A 182GLU A 325 | GOL A 706 (-4.2A)NoneNoneNone | 0.99A | 4ae1A-3ve2A:undetectable | 4ae1A-3ve2A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vpz | GLUCOKINASE (Pseudoalteromonassp. AS-131) |
PF02685(Glucokinase) | 4 | GLY A 320ALA A 115TYR A 118GLU A 108 | None | 0.82A | 4ae1A-3vpzA:undetectable | 4ae1A-3vpzA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vtf | UDP-GLUCOSE6-DEHYDROGENASE (Pyrobaculumislandicum) |
PF00984(UDPG_MGDP_dh)PF03720(UDPG_MGDP_dh_C)PF03721(UDPG_MGDP_dh_N) | 4 | GLY A 29ALA A 68TYR A 30GLU A 72 | None | 0.94A | 4ae1A-3vtfA:undetectable | 4ae1A-3vtfA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3zk2 | ATP SYNTHASE SUBUNITC (Fusobacteriumnucleatum) |
PF00137(ATP-synt_C) | 4 | GLY A 33ALA A 35TYR A 34GLU A 41 | None | 0.99A | 4ae1A-3zk2A:undetectable | 4ae1A-3zk2A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ade | SUCCINYLORNITHINETRANSAMINASE (Escherichiacoli) |
PF00202(Aminotran_3) | 4 | HIS A 127GLY A 125ALA A 120TYR A 124 | None | 0.98A | 4ae1A-4adeA:undetectable | 4ae1A-4adeA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ae0 | DIPHTHERIA TOXIN (Corynebacteriumdiphtheriae) |
PF01324(Diphtheria_R)PF02763(Diphtheria_C)PF02764(Diphtheria_T) | 6 | HIS A 21GLY A 22TYR A 54ALA A 62TYR A 65GLU A 148 | None | 0.41A | 4ae1A-4ae0A:48.6 | 4ae1A-4ae0A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bem | F1FO ATPASE C1SUBUNIT (Acetobacteriumwoodii) |
PF00137(ATP-synt_C) | 4 | GLY J 130ALA J 132TYR J 131GLU J 138 | None | 0.94A | 4ae1A-4bemJ:undetectable | 4ae1A-4bemJ:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bt6 | ALPHA-ACETOLACTATEDECARBOXYLASE (Brevibacillusbrevis) |
PF03306(AAL_decarboxy) | 4 | HIS A 196GLY A 206ALA A 144GLU A 255 | ZN A1257 ( 3.3A)NoneNoneNone | 0.95A | 4ae1A-4bt6A:undetectable | 4ae1A-4bt6A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4f0d | POLY [ADP-RIBOSE]POLYMERASE 16 (Homo sapiens) |
PF00644(PARP) | 5 | HIS A 152GLY A 153TYR A 182ALA A 190TYR A 193 | 3AB A 301 (-4.0A)3AB A 301 (-3.4A)3AB A 301 (-4.3A)3AB A 301 (-3.9A)3AB A 301 (-3.8A) | 0.43A | 4ae1A-4f0dA:5.0 | 4ae1A-4f0dA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4f0e | POLY [ADP-RIBOSE]POLYMERASE 15 (Homo sapiens) |
PF00644(PARP) | 4 | HIS A 537GLY A 538TYR A 569TYR A 582 | 0RU A 701 (-3.7A)0RU A 701 (-3.3A)0RU A 701 (-4.3A)0RU A 701 (-3.7A) | 0.30A | 4ae1A-4f0eA:6.1 | 4ae1A-4f0eA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4l2k | TANKYRASE-2 (Homo sapiens) |
PF00644(PARP) | 4 | HIS A1031GLY A1032TYR A1060TYR A1071 | 1V8 A1201 (-4.2A)1V8 A1201 (-3.7A)1V8 A1201 (-4.7A)1V8 A1201 (-3.3A) | 0.39A | 4ae1A-4l2kA:2.9 | 4ae1A-4l2kA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4oa7 | TANKYRASE-1 (Homo sapiens) |
PF00644(PARP) | 5 | HIS A1184GLY A1185TYR A1213TYR A1224GLU A1291 | 2XS A1402 (-4.2A)None2XS A1402 (-4.2A)2XS A1402 ( 3.9A)None | 0.83A | 4ae1A-4oa7A:6.3 | 4ae1A-4oa7A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4oqa | POLY [ADP-RIBOSE]POLYMERASE 1 (Homo sapiens) |
PF00644(PARP)PF02877(PARP_reg)PF05406(WGR) | 5 | HIS C 862GLY C 863TYR C 896TYR C 907GLU C 988 | 2US C1101 (-3.7A)2US C1101 (-3.3A)2US C1101 (-4.2A)2US C1101 (-3.5A)2US C1101 (-3.2A) | 0.53A | 4ae1A-4oqaC:6.3 | 4ae1A-4oqaC:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4p48 | ANTIBODY SCFV 180 (Gallus gallus) |
PF07686(V-set) | 4 | GLY A 102TYR A 87ALA A 103TYR A 88 | None | 0.98A | 4ae1A-4p48A:3.5 | 4ae1A-4p48A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4p49 | ANTIBODY SCFV B8 (Gallus gallus) |
PF07686(V-set) | 4 | GLY A 94TYR A 81ALA A 95TYR A 82 | None | 1.00A | 4ae1A-4p49A:3.7 | 4ae1A-4p49A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ptf | DNA POLYMERASEEPSILON CATALYTICSUBUNIT A (Saccharomycescerevisiae) |
PF00136(DNA_pol_B)PF03104(DNA_pol_B_exo1) | 4 | GLY A 564TYR A 969ALA A 563GLU A 873 | None | 0.90A | 4ae1A-4ptfA:undetectable | 4ae1A-4ptfA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4py4 | POLY [ADP-RIBOSE]POLYMERASE 14 (Homo sapiens) |
PF00644(PARP) | 4 | HIS A1682GLY A1683TYR A1714TYR A1727 | XL2 A1901 (-4.0A)XL2 A1901 (-3.6A)XL2 A1901 (-3.7A)XL2 A1901 (-3.6A) | 0.29A | 4ae1A-4py4A:6.8 | 4ae1A-4py4A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4sli | INTRAMOLECULARTRANS-SIALIDASE (Macrobdelladecora) |
PF02973(Sialidase)PF13088(BNR_2) | 4 | GLY A 237TYR A 152TYR A 246GLU A 162 | None | 0.98A | 4ae1A-4sliA:undetectable | 4ae1A-4sliA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4x8k | RNA POLYMERASE SIGMAFACTOR SIGA (Mycobacteriumtuberculosis) |
PF00140(Sigma70_r1_2)PF04542(Sigma70_r2) | 4 | GLY A 256ALA A 259TYR A 258GLU A 265 | None | 0.94A | 4ae1A-4x8kA:undetectable | 4ae1A-4x8kA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zzy | POLY [ADP-RIBOSE]POLYMERASE 2 (Homo sapiens) |
PF00644(PARP)PF02877(PARP_reg) | 5 | HIS A 428GLY A 429TYR A 462TYR A 473GLU A 558 | D7N A1584 (-3.6A)D7N A1584 (-3.8A)D7N A1584 (-3.7A)D7N A1584 (-3.8A)D7N A1584 (-3.9A) | 0.60A | 4ae1A-4zzyA:6.1 | 4ae1A-4zzyA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5bp3 | MYCOCEROSIC ACIDSYNTHASE-LIKEPOLYKETIDE SYNTHASE (Mycolicibacteriumsmegmatis) |
PF14765(PS-DH) | 4 | GLY A1132ALA A1130TYR A1131GLU A1157 | None | 0.90A | 4ae1A-5bp3A:undetectable | 4ae1A-5bp3A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dcz | TANKYRASE-2 (Homo sapiens) |
PF00644(PARP) | 4 | HIS A1031GLY A1032TYR A1060TYR A1071 | 59B A1203 (-4.1A)59B A1203 (-4.1A)59B A1203 (-4.3A)59B A1203 (-3.3A) | 0.29A | 4ae1A-5dczA:6.8 | 4ae1A-5dczA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dcz | TANKYRASE-2 (Homo sapiens) |
PF00644(PARP) | 4 | HIS A1031GLY A1032TYR A1071GLU A1138 | 59B A1203 (-4.1A)59B A1203 (-4.1A)59B A1203 (-3.3A)59B A1203 (-3.7A) | 0.77A | 4ae1A-5dczA:6.8 | 4ae1A-5dczA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dsy | POLY [ADP-RIBOSE]POLYMERASE 2 (Homo sapiens) |
PF00644(PARP) | 5 | HIS A 415GLY A 416TYR A 449TYR A 460GLU A 545 | UHB A1001 (-3.7A)UHB A1001 (-3.9A)UHB A1001 (-3.8A)UHB A1001 (-3.4A)UHB A1001 (-3.5A) | 0.69A | 4ae1A-5dsyA:5.4 | 4ae1A-5dsyA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5f7u | CYCLOALTERNAN-FORMING ENZYME (Listeriamonocytogenes) |
PF01055(Glyco_hydro_31)PF13802(Gal_mutarotas_2)PF16338(DUF4968)PF16990(CBM_35) | 4 | GLY A 936TYR A 938ALA A 922TYR A 937 | None | 0.96A | 4ae1A-5f7uA:3.2 | 4ae1A-5f7uA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ghs | SSDNA-SPECIFICEXONUCLEASE (Thermococcuskodakarensis) |
PF02272(DHHA1) | 4 | GLY A 314TYR A 325ALA A 316GLU A 322 | None | 1.00A | 4ae1A-5ghsA:undetectable | 4ae1A-5ghsA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hqw | PUTATIVE POLYKETIDESYNTHASE (Brevibacillusbrevis) |
PF14765(PS-DH) | 4 | HIS A2332TYR A2319ALA A2290GLU A2317 | None | 1.01A | 4ae1A-5hqwA:undetectable | 4ae1A-5hqwA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5k8o | 5-NITROANTHRANILICACID AMINOHYDROLASE (Bradyrhizobiumsp.) |
PF01546(Peptidase_M20)PF07687(M20_dimer) | 4 | GLY A 39TYR A 46ALA A 40GLU A 47 | None | 0.93A | 4ae1A-5k8oA:undetectable | 4ae1A-5k8oA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5l2l | NAB2P (Saccharomycescerevisiae) |
PF14608(zf-CCCH_2) | 4 | HIS A 430GLY A 418TYR A 428GLU A 413 | ZN A 501 (-3.3A)None A G 3 ( 3.9A) ZN A 504 (-2.6A) | 0.70A | 4ae1A-5l2lA:undetectable | 4ae1A-5l2lA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5lx6 | POLY [ADP-RIBOSE]POLYMERASE 10 (Homo sapiens) |
PF00644(PARP) | 4 | HIS A 887GLY A 888TYR A 919TYR A 932 | 78P A1101 (-4.0A)78P A1101 (-3.7A)78P A1101 (-3.7A)78P A1101 (-3.8A) | 0.34A | 4ae1A-5lx6A:6.0 | 4ae1A-5lx6A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5nh2 | UNCHARACTERIZEDPROTEIN (Bartonellahenselae) |
no annotation | 4 | GLY B 49ALA B 51TYR B 50GLU B 17 | GLY B 49 ( 0.0A)ALA B 51 ( 0.0A)TYR B 50 ( 1.3A)GLU B 17 ( 0.5A) | 0.91A | 4ae1A-5nh2B:undetectable | 4ae1A-5nh2B:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ols | RHAMNOGALACTURONANLYASE (Bacteroidesthetaiotaomicron) |
no annotation | 4 | HIS A 326GLY A 287ALA A 286GLU A 307 | None | 0.93A | 4ae1A-5olsA:undetectable | 4ae1A-5olsA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ovc | SH3 AND MULTIPLEANKYRIN REPEATDOMAINS PROTEIN 3 (Rattusnorvegicus) |
no annotation | 4 | HIS A 652GLY A 597ALA A 598GLU A 601 | None | 0.98A | 4ae1A-5ovcA:undetectable | 4ae1A-5ovcA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5oy0 | PHOTOSYSTEM I P700CHLOROPHYLL AAPOPROTEIN A1 (Synechocystissp. PCC 6803) |
no annotation | 4 | HIS 1 590GLY 1 587TYR 1 555ALA 1 409 | None | 0.92A | 4ae1A-5oy01:undetectable | 4ae1A-5oy01:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xst | POLY [ADP-RIBOSE]POLYMERASE 1 (Homo sapiens) |
no annotation | 5 | HIS A 201GLY A 202TYR A 235TYR A 246GLU A 327 | 8E6 A 401 (-3.5A)8E6 A 401 (-3.9A)8E6 A 401 (-4.1A)8E6 A 401 (-3.4A)8E6 A 401 (-3.9A) | 0.57A | 4ae1A-5xstA:6.6 | 4ae1A-5xstA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6bhv | POLY [ADP-RIBOSE]POLYMERASE 1 (Homo sapiens) |
no annotation | 5 | HIS A 862GLY A 863TYR A 896TYR A 907GLU A 988 | DQV A1101 (-3.6A)DQV A1101 (-3.8A)DQV A1101 (-3.5A)DQV A1101 (-3.7A)DQV A1101 (-3.3A) | 0.57A | 4ae1A-6bhvA:6.5 | 4ae1A-6bhvA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6ejm | SINGLE CHAIN FVFRAGMENT (Mus musculus) |
no annotation | 4 | GLY H 278TYR H 265ALA H 279TYR H 266 | None | 0.98A | 4ae1A-6ejmH:3.3 | 4ae1A-6ejmH:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6er3 | BNR/ASP-BOX REPEATPROTEIN ([Ruminococcus]gnavus) |
no annotation | 4 | GLY A 160TYR A 75TYR A 169GLU A 85 | NoneSIA A 201 ( 4.4A)NoneSIA A 201 (-3.1A) | 1.00A | 4ae1A-6er3A:undetectable | 4ae1A-6er3A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6esq | HYDROXYMETHYLGLUTARYL-COA SYNTHASE (Methanothermococcusthermolithotrophicus) |
no annotation | 4 | GLY I 10TYR I 12ALA I 63GLU I 58 | None | 0.89A | 4ae1A-6esqI:undetectable | 4ae1A-6esqI:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6f34 | AMINO ACIDTRANSPORTER (Geobacilluskaustophilus) |
no annotation | 4 | GLY A 221ALA A 57TYR A 217GLU A 55 | None | 0.88A | 4ae1A-6f34A:undetectable | 4ae1A-6f34A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6fhw | GLUCOAMYLASE P (Amorphothecaresinae) |
no annotation | 4 | HIS A 111GLY A 497ALA A 496GLU A 107 | None | 0.86A | 4ae1A-6fhwA:undetectable | 4ae1A-6fhwA:undetectable |