SIMILAR PATTERNS OF AMINO ACIDS FOR 4ACB_C_DXCC1476_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pw4 GLYCEROL-3-PHOSPHATE
TRANSPORTER

(Escherichia
coli) 		PF07690
(MFS_1) 		4 ILE A  34
HIS A 147
MET A 145
ARG A  27
 None
 1.30A 4acbB-1pw4A:
0.0
4acbC-1pw4A:
0.0		 4acbB-1pw4A:
22.63
4acbC-1pw4A:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wz2 LEUCYL-TRNA
SYNTHETASE

(Pyrococcus
horikoshii) 		PF00133
(tRNA-synt_1)
PF08264
(Anticodon_1) 		4 ILE A 590
HIS A 592
MET A 594
ARG A  28
 None
 1.11A 4acbB-1wz2A:
0.0
4acbC-1wz2A:
0.6		 4acbB-1wz2A:
20.50
4acbC-1wz2A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dyv SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR

(Xanthobacter
autotrophicus) 		PF00106
(adh_short) 		4 ILE A 159
HIS A 198
MET A 149
ARG A 147
 None
 1.29A 4acbB-4dyvA:
6.5
4acbC-4dyvA:
4.2		 4acbB-4dyvA:
20.48
4acbC-4dyvA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g7e UREASE

(Cajanus cajan) 		PF00449
(Urease_alpha)
PF00547
(Urease_gamma)
PF00699
(Urease_beta)
PF01979
(Amidohydro_1) 		4 ILE B 620
HIS B 622
MET B 624
ARG B 672
 None
 1.48A 4acbB-4g7eB:
0.1
4acbC-4g7eB:
1.8		 4acbB-4g7eB:
20.09
4acbC-4g7eB:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jzj INTERLEUKIN-3
RECEPTOR SUBUNIT
ALPHA

(Homo sapiens) 		PF09240
(IL6Ra-bind) 		4 ILE C 271
HIS C 224
MET C 223
ARG C 256
 None
 1.00A 4acbB-4jzjC:
0.3
4acbC-4jzjC:
0.0		 4acbB-4jzjC:
17.94
4acbC-4jzjC:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4on3 SORTING NEXIN-10

(Homo sapiens) 		PF00787
(PX) 		4 ILE A  30
HIS A  90
MET A  85
ARG A  88
 None
NO3  A 302 (-4.4A)
None
None
 1.45A 4acbB-4on3A:
0.0
4acbC-4on3A:
0.0		 4acbB-4on3A:
17.94
4acbC-4on3A:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rm9 EZRIN

(Homo sapiens) 		PF00373
(FERM_M)
PF00769
(ERM)
PF09379
(FERM_N)
PF09380
(FERM_C) 		4 ILE A 153
HIS A 161
MET A 158
ARG A 171
 None
 1.43A 4acbB-4rm9A:
0.0
4acbC-4rm9A:
0.0		 4acbB-4rm9A:
23.14
4acbC-4rm9A:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k6u PROTEIN SIDEKICK-1

(Mus musculus) 		PF07679
(I-set)
PF13927
(Ig_3) 		4 ILE A 308
HIS A 346
MET A 306
ARG A 336
 None
 1.22A 4acbB-5k6uA:
0.0
4acbC-5k6uA:
0.1		 4acbB-5k6uA:
23.01
4acbC-5k6uA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k6w PROTEIN SIDEKICK-1

(Mus musculus) 		PF07679
(I-set)
PF13927
(Ig_3) 		4 ILE A 308
HIS A 346
MET A 306
ARG A 336
 None
 1.25A 4acbB-5k6wA:
0.0
4acbC-5k6wA:
0.0		 4acbB-5k6wA:
23.33
4acbC-5k6wA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k6z PROTEIN
SIDEKICK-2,PROTEIN
SIDEKICK-1 CHIMERA

(Mus musculus) 		PF07679
(I-set)
PF13927
(Ig_3) 		4 ILE A 308
HIS A 346
MET A 306
ARG A 336
 None
 1.23A 4acbB-5k6zA:
undetectable
4acbC-5k6zA:
undetectable		 4acbB-5k6zA:
23.33
4acbC-5k6zA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ue8 PROTEIN UNC-13
HOMOLOG A

(Rattus
norvegicus) 		PF00130
(C1_1)
PF00168
(C2)
PF06292
(DUF1041)
PF10540
(Membr_traf_MHD) 		4 ILE A1216
HIS A1229
MET A1231
ARG A1233
 None
 1.43A 4acbB-5ue8A:
undetectable
4acbC-5ue8A:
undetectable		 4acbB-5ue8A:
19.90
4acbC-5ue8A:
19.90