SIMILAR PATTERNS OF AMINO ACIDS FOR 4ACA_C_DXCC1477_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e1t LYSYL-TRNA
SYNTHETASE, HEAT
INDUCIBLE

(Escherichia
coli) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon) 		4 THR A  86
ARG A  41
ILE A 121
LEU A 117
 None
 1.14A 4acaC-1e1tA:
undetectable		 4acaC-1e1tA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ezw COENZYME
F420-DEPENDENT
N5,N10-METHYLENETETR
AHYDROMETHANOPTERIN
REDUCTASE

(Methanopyrus
kandleri) 		PF00296
(Bac_luciferase) 		4 THR A 185
GLY A 187
ILE A 224
LEU A 183
 None
 1.26A 4acaC-1ezwA:
undetectable		 4acaC-1ezwA:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hjv CHITINASE-3 LIKE
PROTEIN 1

(Homo sapiens) 		PF00704
(Glyco_hydro_18) 		4 GLY A 262
ARG A 310
ILE A 299
LEU A 356
 None
None
None
NAG  A  -2 (-4.9A)
 0.88A 4acaC-1hjvA:
2.1		 4acaC-1hjvA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j0n XANTHAN LYASE

(Bacillus sp.
GL1) 		PF02278
(Lyase_8)
PF02884
(Lyase_8_C)
PF08124
(Lyase_8_N) 		4 GLY A 205
ARG A 101
ILE A 202
LEU A 270
 None
 1.09A 4acaC-1j0nA:
undetectable		 4acaC-1j0nA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k27 5'-DEOXY-5'-METHYLTH
IOADENOSINE
PHOSPHORYLASE

(Homo sapiens) 		PF01048
(PNP_UDP_1) 		4 THR A 188
GLY A 190
ILE A 114
LEU A  98
 None
 1.19A 4acaC-1k27A:
4.0		 4acaC-1k27A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k7h ALKALINE PHOSPHATASE

(Pandalus
borealis) 		PF00245
(Alk_phosphatase) 		4 THR A 271
GLY A 203
ARG A 162
LEU A 273
 SO4  A 483 ( 4.5A)
None
None
None
 0.94A 4acaC-1k7hA:
undetectable		 4acaC-1k7hA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1leh LEUCINE
DEHYDROGENASE

(Lysinibacillus
sphaericus) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		4 THR A 150
GLY A 153
ILE A 286
LEU A 188
 None
 1.11A 4acaC-1lehA:
undetectable		 4acaC-1lehA:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1los OROTIDINE
MONOPHOSPHATE
DECARBOXYLASE

(Methanothermobacter
thermautotrophicus) 		PF00215
(OMPdecase) 		4 GLY A 156
ARG A   5
ILE A 178
LEU A 123
 None
 1.01A 4acaC-1losA:
3.2		 4acaC-1losA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lox 15-LIPOXYGENASE

(Oryctolagus
cuniculus) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		4 THR A 504
GLY A 507
ARG A 364
ILE A 150
 None
 1.19A 4acaC-1loxA:
undetectable		 4acaC-1loxA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1luj CATENIN BETA-1

(Homo sapiens) 		PF00514
(Arm) 		4 THR A 574
GLY A 572
ILE A 569
LEU A 536
 None
 1.10A 4acaC-1lujA:
undetectable		 4acaC-1lujA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n8y PROTOONCOPROTEIN

(Rattus
norvegicus) 		PF00757
(Furin-like)
PF01030
(Recep_L_domain)
PF14843
(GF_recep_IV) 		4 THR C 386
GLY C 412
ARG C 408
LEU C 292
 None
 1.18A 4acaC-1n8yC:
undetectable		 4acaC-1n8yC:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o9b HYPOTHETICAL
SHIKIMATE
5-DEHYDROGENASE-LIKE
PROTEIN YDIB

(Escherichia
coli) 		PF08501
(Shikimate_dh_N) 		4 THR A 137
GLY A 140
ILE A 151
LEU A  87
 None
 0.89A 4acaC-1o9bA:
3.5		 4acaC-1o9bA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r6b CLPA PROTEIN

(Escherichia
coli) 		PF00004
(AAA)
PF02861
(Clp_N)
PF07724
(AAA_2)
PF10431
(ClpB_D2-small) 		4 THR X 221
GLY X 219
ILE X 346
LEU X 188
 MG  X 782 ( 3.2A)
ADP  X 780 (-3.1A)
None
ADP  X 780 (-4.5A)
 1.24A 4acaC-1r6bX:
undetectable		 4acaC-1r6bX:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sdd COAGULATION FACTOR V

(Bos taurus) 		PF07732
(Cu-oxidase_3) 		4 THR A  61
GLY A 160
ILE A 230
LEU A 162
 None
 1.23A 4acaC-1sddA:
undetectable		 4acaC-1sddA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t8b PHOSPHATE TRANSPORT
SYSTEM PROTEIN PHOU
HOMOLOG

(Aquifex
aeolicus) 		PF01895
(PhoU) 		4 GLY A  98
ARG A 192
ILE A 197
LEU A  94
 None
 0.88A 4acaC-1t8bA:
undetectable		 4acaC-1t8bA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tz6 PUTATIVE SUGAR
KINASE

(Salmonella
enterica) 		PF00294
(PfkB) 		4 GLY A 144
ARG A  77
ILE A  10
LEU A 142
 None
 1.11A 4acaC-1tz6A:
4.0		 4acaC-1tz6A:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1up4 6-PHOSPHO-BETA-GLUCO
SIDASE

(Thermotoga
maritima) 		PF02056
(Glyco_hydro_4)
PF11975
(Glyco_hydro_4C) 		4 THR A 104
GLY A 106
ARG A 243
ILE A 100
 None
 1.10A 4acaC-1up4A:
4.0		 4acaC-1up4A:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vzy 33 KDA CHAPERONIN

(Bacillus
subtilis) 		PF01430
(HSP33) 		4 THR A 112
GLY A  68
ARG A  44
ILE A  66
 None
 1.05A 4acaC-1vzyA:
undetectable		 4acaC-1vzyA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w5f CELL DIVISION
PROTEIN FTSZ

(Thermotoga
maritima) 		PF00091
(Tubulin)
PF12327
(FtsZ_C) 		4 THR A 119
GLY A  88
ILE A  75
LYS A  98
 G2P  A 500 (-3.6A)
None
None
None
 1.05A 4acaC-1w5fA:
5.8		 4acaC-1w5fA:
24.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wle SERYL-TRNA
SYNTHETASE

(Bos taurus) 		PF00587
(tRNA-synt_2b) 		4 THR A 432
GLY A 338
ILE A 303
LEU A 287
 None
 0.94A 4acaC-1wleA:
undetectable		 4acaC-1wleA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xr5 GENOME POLYPROTEIN

(Rhinovirus B) 		PF00680
(RdRP_1) 		4 GLY A 288
ARG A 163
ILE A 176
LEU A 154
 None
 1.23A 4acaC-1xr5A:
undetectable		 4acaC-1xr5A:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bs4 QUINOL-FUMARATE
REDUCTASE DIHEME
CYTOCHROME B SUBUNIT
C

(Wolinella
succinogenes) 		PF01127
(Sdh_cyt) 		4 THR C 227
GLY C 229
ARG C 162
LEU C 225
 HEM  C1256 ( 4.4A)
None
HEM  C1256 (-3.8A)
None
 1.16A 4acaC-2bs4C:
undetectable		 4acaC-2bs4C:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c8j FERROCHELATASE 1

(Bacillus
anthracis) 		PF00762
(Ferrochelatase) 		4 THR A  14
ARG A 127
ILE A  28
LEU A 262
 None
 1.21A 4acaC-2c8jA:
4.3		 4acaC-2c8jA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j92 PICORNAIN 3C

(Foot-and-mouth
disease virus) 		PF00548
(Peptidase_C3) 		4 THR A  16
GLY A  35
ILE A  99
LEU A  42
 None
 1.24A 4acaC-2j92A:
2.5		 4acaC-2j92A:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mng POTASSIUM/SODIUM
HYPERPOLARIZATION-AC
TIVATED CYCLIC
NUCLEOTIDE-GATED
CHANNEL 4

(Homo sapiens) 		PF00027
(cNMP_binding) 		4 THR A 665
GLY A 629
ILE A 623
LEU A 663
 None
 0.95A 4acaC-2mngA:
undetectable		 4acaC-2mngA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ps2 PUTATIVE MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME

(Aspergillus
oryzae) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 THR A 277
GLY A 279
ILE A 270
LEU A 128
 None
 1.10A 4acaC-2ps2A:
3.0		 4acaC-2ps2A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q2l SUPEROXIDE DISMUTASE

(Potentilla
atrosanguinea) 		PF00080
(Sod_Cu) 		4 THR A  21
GLY A   4
ILE A 148
LEU A  19
 None
 0.99A 4acaC-2q2lA:
undetectable		 4acaC-2q2lA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qm1 GLUCOKINASE

(Enterococcus
faecalis) 		PF00480
(ROK) 		4 THR A  14
GLY A  12
ILE A  36
LEU A  10
 None
 1.14A 4acaC-2qm1A:
undetectable		 4acaC-2qm1A:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wlv GAG POLYPROTEIN

(Human
immunodeficiency
virus 2) 		PF00607
(Gag_p24) 		4 THR B  47
GLY B 126
ARG B  95
ILE B 102
 None
 1.04A 4acaC-2wlvB:
undetectable		 4acaC-2wlvB:
13.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x0s PYRUVATE PHOSPHATE
DIKINASE

(Trypanosoma
brucei) 		PF00391
(PEP-utilizers)
PF01326
(PPDK_N)
PF02896
(PEP-utilizers_C) 		4 THR A 795
GLY A 798
ARG A 690
LEU A 835
 None
 1.22A 4acaC-2x0sA:
2.8		 4acaC-2x0sA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xio PUTATIVE
DEOXYRIBONUCLEASE
TATDN1

(Homo sapiens) 		PF01026
(TatD_DNase) 		4 GLY A  75
ARG A 167
ILE A 110
LEU A  99
 None
 0.83A 4acaC-2xioA:
2.9		 4acaC-2xioA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xwu IMPORTIN13

(Homo sapiens) 		PF03810
(IBN_N)
PF08389
(Xpo1) 		4 THR B 304
GLY B 307
ILE B 311
LEU B 293
 None
 1.01A 4acaC-2xwuB:
undetectable		 4acaC-2xwuB:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y9y ISWI ONE COMPLEX
PROTEIN 3

(Saccharomyces
cerevisiae) 		PF15612
(WHIM1) 		4 THR B 433
GLY B 541
ARG B 553
LEU B 154
 None
 1.17A 4acaC-2y9yB:
undetectable		 4acaC-2y9yB:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ya2 PUTATIVE ALKALINE
AMYLOPULLULANASE

(Streptococcus
pneumoniae) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48) 		4 GLY A 472
ARG A 408
ILE A 436
LEU A 469
 None
 1.24A 4acaC-2ya2A:
undetectable		 4acaC-2ya2A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yy6 PHOSPHOGLYCOLATE
PHOSPHATASE

(Aquifex
aeolicus) 		PF13419
(HAD_2) 		4 THR A 163
GLY A 161
ARG A 172
ILE A 159
 None
 1.25A 4acaC-2yy6A:
3.8		 4acaC-2yy6A:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z6h CATENIN BETA-1

(Homo sapiens) 		PF00514
(Arm) 		4 THR A 574
GLY A 572
ILE A 569
LEU A 536
 None
 1.11A 4acaC-2z6hA:
undetectable		 4acaC-2z6hA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zzr UNSATURATED
GLUCURONYL HYDROLASE

(Streptococcus
agalactiae) 		PF07470
(Glyco_hydro_88) 		4 GLY A 252
ILE A 174
LYS A   5
LEU A 271
 None
None
SO4  A 401 ( 4.3A)
None
 1.07A 4acaC-2zzrA:
undetectable		 4acaC-2zzrA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bwx ALPHA/BETA HYDROLASE

(Novosphingobium
aromaticivorans) 		PF12697
(Abhydrolase_6) 		4 THR A 212
GLY A 210
ILE A 141
LEU A 105
 None
CL  A 287 (-4.0A)
None
EDO  A 300 (-3.2A)
 1.13A 4acaC-3bwxA:
4.2		 4acaC-3bwxA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3by5 COBALAMIN
BIOSYNTHESIS PROTEIN

(Agrobacterium
fabrum) 		PF01890
(CbiG_C) 		4 GLY A  12
ARG A 110
ILE A 125
LEU A  42
 None
 1.11A 4acaC-3by5A:
undetectable		 4acaC-3by5A:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d8b FIDGETIN-LIKE
PROTEIN 1

(Homo sapiens) 		PF00004
(AAA)
PF09336
(Vps4_C) 		4 THR A 445
GLY A 605
ILE A 576
LEU A 449
 ADP  A 900 (-4.3A)
ADP  A 900 (-3.7A)
ADP  A 900 ( 4.7A)
ADP  A 900 (-4.0A)
 1.12A 4acaC-3d8bA:
undetectable		 4acaC-3d8bA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dwb ENDOTHELIN-CONVERTIN
G ENZYME 1

(Homo sapiens) 		PF01431
(Peptidase_M13)
PF05649
(Peptidase_M13_N) 		4 THR A 212
GLY A 294
ILE A 300
LEU A 292
 None
 1.13A 4acaC-3dwbA:
undetectable		 4acaC-3dwbA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eq1 PORPHOBILINOGEN
DEAMINASE

(Homo sapiens) 		PF01379
(Porphobil_deam)
PF03900
(Porphobil_deamC) 		4 GLY A 346
ARG A 156
ILE A 350
LEU A 343
 None
 1.21A 4acaC-3eq1A:
undetectable		 4acaC-3eq1A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g8y SUSD/RAGB-ASSOCIATED
ESTERASE-LIKE
PROTEIN

(Bacteroides
vulgatus) 		PF12715
(Abhydrolase_7) 		4 THR A 228
GLY A 226
ILE A 310
LEU A 217
 None
None
EDO  A   9 (-4.6A)
None
 1.21A 4acaC-3g8yA:
2.5		 4acaC-3g8yA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hee RIBOSE-5-PHOSPHATE
ISOMERASE

(Ruminiclostridium
thermocellum) 		PF02502
(LacAB_rpiB) 		4 THR A  34
GLY A   6
ARG A 109
ILE A  71
 None
None
R5P  A 651 (-3.3A)
None
 1.11A 4acaC-3heeA:
2.5		 4acaC-3heeA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ifq PLAKOGLOBIN

(Homo sapiens) 		PF00514
(Arm) 		4 THR A 564
GLY A 562
ILE A 559
LEU A 527
 None
 1.10A 4acaC-3ifqA:
undetectable		 4acaC-3ifqA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iib PEPTIDASE M28

(Shewanella
amazonensis) 		PF04389
(Peptidase_M28) 		4 THR A 173
GLY A 176
ARG A 135
ILE A 194
 None
None
PEG  A   4 (-3.8A)
None
 1.26A 4acaC-3iibA:
2.9		 4acaC-3iibA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j7y BL17

(Homo sapiens) 		PF01196
(Ribosomal_L17) 		4 GLY O  35
ARG O 113
ILE O  42
LEU O  33
 A  A2319 ( 3.5A)
G  A2454 ( 4.6A)
A  A2319 ( 3.9A)
None
 1.01A 4acaC-3j7yO:
undetectable		 4acaC-3j7yO:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3miz PUTATIVE
TRANSCRIPTIONAL
REGULATOR PROTEIN,
LACI FAMILY

(Rhizobium etli) 		PF13377
(Peripla_BP_3) 		4 THR A 141
GLY A 119
ILE A 117
LEU A 121
 None
 1.26A 4acaC-3mizA:
undetectable		 4acaC-3mizA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rgg PHOSPHORIBOSYLAMINOI
MIDAZOLE
CARBOXYLASE, PURE
PROTEIN

(Treponema
denticola) 		PF00731
(AIRC) 		4 THR A  27
GLY A  29
ILE A 135
LEU A  25
 None
 1.04A 4acaC-3rggA:
3.2		 4acaC-3rggA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rmt 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE 1

(Bacillus
halodurans) 		PF00275
(EPSP_synthase) 		4 GLY A 268
ARG A 202
ILE A 237
LEU A 273
 None
 1.17A 4acaC-3rmtA:
undetectable		 4acaC-3rmtA:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rpb RABPHILIN 3-A

(Rattus
norvegicus) 		PF00168
(C2) 		4 THR A 552
GLY A 556
ILE A 558
LEU A 620
 None
 1.18A 4acaC-3rpbA:
undetectable		 4acaC-3rpbA:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sqn CONSERVED DOMAIN
PROTEIN

(Enterococcus
faecalis) 		PF05043
(Mga) 		4 THR A 114
GLY A 116
ILE A  92
LEU A 112
 None
 1.17A 4acaC-3sqnA:
3.6		 4acaC-3sqnA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sto SERINE PROTEASE
INHIBITOR

(Schistosoma
haematobium) 		PF00079
(Serpin) 		4 THR A  49
GLY A  51
ILE A  67
LEU A  47
 None
 0.77A 4acaC-3stoA:
undetectable		 4acaC-3stoA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vpx LEUCINE
DEHYDROGENASE

(Sporosarcina
psychrophila) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		4 THR A 150
GLY A 153
ILE A 286
LEU A 188
 None
 1.07A 4acaC-3vpxA:
undetectable		 4acaC-3vpxA:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vv4 METHYL-ACCEPTING
CHEMOTAXIS PROTEIN

(Thermosynechococcus
elongatus) 		PF01590
(GAF) 		4 GLY A 148
ARG A  10
ILE A  15
LEU A 144
 None
 1.20A 4acaC-3vv4A:
undetectable		 4acaC-3vv4A:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wry TM-1 PROTEIN

(Solanum
lycopersicum) 		PF06792
(UPF0261) 		4 GLY A 264
ARG A 258
ILE A 262
LEU A 266
 None
 1.05A 4acaC-3wryA:
5.1		 4acaC-3wryA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zx2 ECTONUCLEOSIDE
TRIPHOSPHATE
DIPHOSPHOHYDROLASE 1

(Rattus
norvegicus) 		PF01150
(GDA1_CD39) 		4 THR A 221
GLY A 209
ILE A 182
LEU A 211
 None
 1.24A 4acaC-3zx2A:
3.2		 4acaC-3zx2A:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b4u BIFUNCTIONAL PROTEIN
FOLD

(Acinetobacter
baumannii) 		PF00763
(THF_DHG_CYH)
PF02882
(THF_DHG_CYH_C) 		4 THR A 141
GLY A 144
ARG A   8
ILE A 148
 None
None
EDO  A1286 (-3.5A)
None
 0.96A 4acaC-4b4uA:
undetectable		 4acaC-4b4uA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b8j IMPORTIN SUBUNIT
ALPHA-1A

(Oryza sativa) 		PF00514
(Arm)
PF01749
(IBB)
PF16186
(Arm_3) 		4 THR A 307
GLY A 309
ILE A 322
LEU A 305
 None
 1.08A 4acaC-4b8jA:
undetectable		 4acaC-4b8jA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bc6 SERINE/THREONINE-PRO
TEIN KINASE 10

(Homo sapiens) 		PF00069
(Pkinase) 		4 THR A 166
GLY A 115
ILE A 121
LEU A 164
 None
None
None
XZN  A1317 (-4.7A)
 0.63A 4acaC-4bc6A:
undetectable		 4acaC-4bc6A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bpl IMPORTIN SUBUNIT
ALPHA-1A

(Oryza sativa) 		PF00514
(Arm)
PF16186
(Arm_3) 		4 THR A 307
GLY A 309
ILE A 322
LEU A 305
 None
 1.12A 4acaC-4bplA:
undetectable		 4acaC-4bplA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dup QUINONE
OXIDOREDUCTASE

(Rhizobium etli) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 THR A 155
GLY A 159
ILE A 151
LEU A 189
 None
 1.13A 4acaC-4dupA:
2.2		 4acaC-4dupA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f92 U5 SMALL NUCLEAR
RIBONUCLEOPROTEIN
200 KDA HELICASE

(Homo sapiens) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF02889
(Sec63) 		4 THR B 561
GLY B 563
ILE B 531
LEU B 559
 None
 1.07A 4acaC-4f92B:
undetectable		 4acaC-4f92B:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hpf POTASSIUM CHANNEL
SUBFAMILY U MEMBER 1

(Homo sapiens) 		PF03493
(BK_channel_a) 		4 THR A 823
GLY A 825
ILE A 861
LEU A 877
 None
 1.24A 4acaC-4hpfA:
5.9		 4acaC-4hpfA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4htw GAG PROTEIN

(Simian
immunodeficiency
virus) 		PF00607
(Gag_p24) 		4 THR A  47
GLY A 125
ARG A  94
ILE A 101
 None
 1.08A 4acaC-4htwA:
undetectable		 4acaC-4htwA:
12.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hyv PYRUVATE KINASE 1

(Trypanosoma
brucei) 		PF00224
(PK)
PF02887
(PK_C) 		4 THR A 112
ARG A 175
ILE A 178
LEU A 162
 None
 1.25A 4acaC-4hyvA:
3.9		 4acaC-4hyvA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i7a ETHANOLAMINE
UTILIZATION PROTEIN
EUTN/CARBOXYSOME
STRUCTURAL PROTEIN
CCML

(Rhodospirillum
rubrum) 		PF03319
(EutN_CcmL) 		4 THR A  46
GLY A  48
ILE A  81
LEU A  25
 None
 1.05A 4acaC-4i7aA:
undetectable		 4acaC-4i7aA:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jdy PYRIDOXAL
BIOSYNTHESIS LYASE
PDXS

(Mycobacterium
tuberculosis) 		PF01680
(SOR_SNZ) 		4 THR A 100
GLY A 102
ILE A  76
LEU A  98
 None
 1.02A 4acaC-4jdyA:
undetectable		 4acaC-4jdyA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lgn CELLULOSE-BINDING,
FAMILY II

(Acidothermus
cellulolyticus) 		no annotation 4 THR A 403
GLY A  17
ILE A  14
LEU A 428
 None
 1.21A 4acaC-4lgnA:
undetectable		 4acaC-4lgnA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lvu OXIDOREDUCTASE,
SHORT CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY

(Burkholderia
thailandensis) 		PF13561
(adh_short_C2) 		4 THR A  39
GLY A  42
ILE A  34
LEU A  69
 None
 1.21A 4acaC-4lvuA:
4.2		 4acaC-4lvuA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n8f CARBON DIOXIDE
CONCENTRATING
MECHANISM PROTEIN

(Thermosynechococcus
elongatus) 		PF03319
(EutN_CcmL) 		4 THR A  46
GLY A  48
ILE A  81
LEU A  25
 None
MG  A 202 (-3.7A)
None
None
 1.10A 4acaC-4n8fA:
undetectable		 4acaC-4n8fA:
12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r6h SOLUTE BINDING
PROTEIN MSME

(Bacillus
subtilis) 		PF01547
(SBP_bac_1) 		4 THR A 368
GLY A 370
ILE A 383
LEU A 366
 None
 1.13A 4acaC-4r6hA:
undetectable		 4acaC-4r6hA:
24.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r8z CYCLIC DI-GMP
PHOSPHODIESTERASE

(Pseudomonas
aeruginosa) 		PF13487
(HD_5) 		4 THR A 250
GLY A 253
ARG A 173
ILE A 222
 None
 1.14A 4acaC-4r8zA:
undetectable		 4acaC-4r8zA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rfq HISTIDINE PROTEIN
METHYLTRANSFERASE 1
HOMOLOG

(Homo sapiens) 		PF13489
(Methyltransf_23) 		4 THR A 204
GLY A 202
ARG A 318
LEU A 200
 None
 1.11A 4acaC-4rfqA:
2.6		 4acaC-4rfqA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ubs PENTALENIC ACID
SYNTHASE

(Streptomyces
avermitilis) 		PF00067
(p450) 		4 GLY A 242
ARG A 175
ILE A 240
LEU A 160
 HEM  A 501 (-3.6A)
PGE  A 506 (-4.0A)
DIF  A 502 (-3.3A)
None
 1.16A 4acaC-4ubsA:
undetectable		 4acaC-4ubsA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uc0 PURINE NUCLEOSIDE
PHOSPHORYLASE

(Agrobacterium
vitis) 		PF01048
(PNP_UDP_1) 		4 THR A 195
GLY A 197
ILE A 128
LEU A 112
 None
 1.19A 4acaC-4uc0A:
undetectable		 4acaC-4uc0A:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4woj ASPARTATE
SEMIALDEHYDE
DEHYDROGENASE

(Francisella
tularensis) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		4 THR A  33
GLY A   5
ARG A  10
ILE A   7
 None
None
SO4  A 402 (-3.1A)
None
 0.73A 4acaC-4wojA:
undetectable		 4acaC-4wojA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ydh FORMIN-LIKE PROTEIN
1

(Homo sapiens) 		PF06367
(Drf_FH3)
PF06371
(Drf_GBD) 		4 THR A 351
GLY A 354
ARG A 305
LEU A 359
 None
 1.26A 4acaC-4ydhA:
undetectable		 4acaC-4ydhA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yzi SENSORY OPSIN
A,ARCHAEAL-TYPE
OPSIN 2

(Chlamydomonas
reinhardtii) 		PF01036
(Bac_rhodopsin) 		4 THR A 285
GLY A 287
ILE A 291
LEU A  94
 None
OLA  A 406 (-3.5A)
None
None
 0.77A 4acaC-4yziA:
undetectable		 4acaC-4yziA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b2h HA-33

(Clostridium
botulinum) 		PF14200
(RicinB_lectin_2) 		4 THR A 197
ARG A  10
ILE A 232
LEU A 207
 None
 1.21A 4acaC-5b2hA:
undetectable		 4acaC-5b2hA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c3m PUTATIVE
6-PHOSPHO-BETA-GLUCO
SIDASE

(Geobacillus
stearothermophilus) 		PF02056
(Glyco_hydro_4)
PF11975
(Glyco_hydro_4C) 		4 THR A 113
GLY A 115
ARG A 259
ILE A 109
 None
 1.11A 4acaC-5c3mA:
4.1		 4acaC-5c3mA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cd6 TPR-DOMAIN
CONTAINING PROTEIN

(Parabacteroides
distasonis) 		PF17128
(DUF5107) 		4 THR A  43
ARG A 563
ILE A 496
LEU A  46
 None
 1.19A 4acaC-5cd6A:
undetectable		 4acaC-5cd6A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5es6 LINEAR GRAMICIDIN
SYNTHASE SUBUNIT A

(Brevibacillus
parabrevis) 		PF00501
(AMP-binding)
PF00551
(Formyl_trans_N) 		4 THR A 484
GLY A 482
ARG A 562
ILE A 533
 None
 1.20A 4acaC-5es6A:
undetectable		 4acaC-5es6A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ezr CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE

(Plasmodium
vivax) 		PF00027
(cNMP_binding)
PF00069
(Pkinase) 		4 THR A 280
ARG A 348
ILE A 328
LEU A 300
 None
 0.89A 4acaC-5ezrA:
undetectable		 4acaC-5ezrA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f5o NUCLEOPROTEIN

(Marburg
marburgvirus) 		PF05505
(Ebola_NP) 		4 GLY A  54
ARG A  82
ILE A 191
LEU A  59
 None
 0.85A 4acaC-5f5oA:
undetectable		 4acaC-5f5oA:
24.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f5o NUCLEOPROTEIN

(Marburg
marburgvirus) 		PF05505
(Ebola_NP) 		4 THR A  58
GLY A  54
ARG A  82
ILE A 191
 None
 1.26A 4acaC-5f5oA:
undetectable		 4acaC-5f5oA:
24.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fkr ENDO-1,4-BETA-GLUCAN
ASE/XYLOGLUCANASE,
PUTATIVE, GLY74A

(Cellvibrio
japonicus) 		no annotation 4 THR A 435
GLY A  49
ILE A  46
LEU A 460
 None
 1.21A 4acaC-5fkrA:
undetectable		 4acaC-5fkrA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g5g PUTATIVE XANTHINE
DEHYDROGENASE YAGT
IRON-SULFUR-BINDING
SUBUNIT
PUTATIVE XANTHINE
DEHYDROGENASE YAGR
MOLYBDENUM-BINDING
SU SUBUNIT

(Escherichia
coli;
Escherichia
coli) 		PF00111
(Fer2)
PF01799
(Fer2_2)
PF00941
(FAD_binding_5)
PF03450
(CO_deh_flav_C) 		4 GLY B  30
ARG B   8
ILE B  28
LEU A 120
 FAD  B 321 (-3.2A)
None
None
None
 1.03A 4acaC-5g5gB:
undetectable		 4acaC-5g5gB:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gju ATP-DEPENDENT RNA
HELICASE DEAD

(Escherichia
coli) 		PF00270
(DEAD) 		4 THR A  52
GLY A  55
ARG A 209
ILE A  32
 AMP  A 301 (-3.6A)
AMP  A 301 (-3.3A)
None
None
 1.10A 4acaC-5gjuA:
3.1		 4acaC-5gjuA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i8i UREA AMIDOLYASE

(Kluyveromyces
lactis) 		PF00289
(Biotin_carb_N)
PF01425
(Amidase)
PF02626
(CT_A_B)
PF02682
(CT_C_D)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 GLY A1588
ILE A1094
LYS A1519
LEU A1663
 None
 1.14A 4acaC-5i8iA:
undetectable		 4acaC-5i8iA:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i93 1,2-DIHYDROXY-3-KETO
-5-METHYLTHIOPENTENE
DIOXYGENASE

(Mus musculus) 		PF03079
(ARD) 		4 THR A  33
GLY A  35
ILE A 131
LEU A  31
 None
 1.07A 4acaC-5i93A:
undetectable		 4acaC-5i93A:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iz5 CYTOSOLIC
PHOSPHOLIPASE A2
DELTA

(Homo sapiens) 		no annotation 4 THR B 364
GLY B 359
ARG B 333
LEU B 463
 None
 1.23A 4acaC-5iz5B:
undetectable		 4acaC-5iz5B:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mac RIBULOSE-1,5-BISPHOS
PHATE
CARBOXYLASE-OXYGENAS
E TYPE III

(Methanococcoides
burtonii) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		4 THR A 267
GLY A 269
ARG A 245
ILE A 263
 None
 1.22A 4acaC-5macA:
undetectable		 4acaC-5macA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ok4 5,10-METHENYLTETRAHY
DROMETHANOPTERIN
HYDROGENASE

(Methanothermobacter
marburgensis) 		no annotation 4 THR A  45
GLY A  47
ILE A   5
LEU A 123
 None
 1.21A 4acaC-5ok4A:
undetectable		 4acaC-5ok4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xcy GLUCANASE

(Phanerochaete
chrysosporium) 		PF01341
(Glyco_hydro_6) 		4 THR A 340
GLY A 293
ILE A 291
LEU A 332
 None
 1.21A 4acaC-5xcyA:
2.9		 4acaC-5xcyA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y2a INSECT GROUP II
CHITINASE

(Ostrinia
furnacalis) 		no annotation 4 GLY A2304
ARG A2355
ILE A2342
LEU A2402
 None
 0.92A 4acaC-5y2aA:
undetectable		 4acaC-5y2aA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ccf CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE KINASE 1

(Homo sapiens) 		no annotation 4 THR A 342
GLY A 340
ILE A 386
LEU A 256
 None
 0.87A 4acaC-6ccfA:
undetectable		 4acaC-6ccfA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ci9 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE

(Mycolicibacterium
smegmatis) 		no annotation 4 THR A  66
GLY A 118
ARG A  73
ILE A 122
 NAP  A 301 ( 4.3A)
None
None
None
 1.24A 4acaC-6ci9A:
4.3		 4acaC-6ci9A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eid ARCHAEAL-TYPE OPSIN
2

(Chlamydomonas
reinhardtii) 		no annotation 4 THR A 246
GLY A 248
ILE A 252
LEU A  55
 None
OLC  A1102 ( 3.7A)
None
None
 0.78A 4acaC-6eidA:
undetectable		 4acaC-6eidA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6enz ACIDIC AMINO ACID
DECARBOXYLASE GADL1

(Mus musculus) 		no annotation 4 THR A  93
GLY A 105
ARG A 475
ILE A 479
 None
 1.03A 4acaC-6enzA:
undetectable		 4acaC-6enzA:
undetectable