SIMILAR PATTERNS OF AMINO ACIDS FOR 4AC9_C_DXCC1475_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1azz COLLAGENASE

(Leptuca
pugilator) 		PF00089
(Trypsin) 		4 ILE A 103
ASP A 102
ILE A 212
GLY A  44
 None
 0.80A 4ac9C-1azzA:
2.3		 4ac9C-1azzA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b63 MUTL

(Escherichia
coli) 		PF01119
(DNA_mis_repair)
PF13589
(HATPase_c_3) 		4 ILE A  56
ASP A  43
ILE A  42
GLY A  38
 None
 0.79A 4ac9C-1b63A:
undetectable		 4ac9C-1b63A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bu3 CALCIUM-BINDING
PROTEIN

(Merluccius
bilinearis) 		PF13499
(EF-hand_7) 		4 ILE A  50
ASP A  51
ILE A  58
GLY A  89
 None
CA  A 109 ( 3.3A)
None
None
 0.85A 4ac9C-1bu3A:
undetectable		 4ac9C-1bu3A:
14.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cli PROTEIN
(PHOSPHORIBOSYL-AMIN
OIMIDAZOLE
SYNTHETASE)

(Escherichia
coli) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		5 ILE A 123
ILE A 126
PHE A 105
VAL A 156
GLY A 158
 None
 1.07A 4ac9C-1cliA:
undetectable		 4ac9C-1cliA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cpt CYTOCHROME P450-TERP

(Pseudomonas sp.) 		PF00067
(p450) 		4 ILE A 338
ASP A 336
ILE A 332
GLY A 329
 None
 0.78A 4ac9C-1cptA:
undetectable		 4ac9C-1cptA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cr5 SEC18P (RESIDUES 22
- 210)

(Saccharomyces
cerevisiae) 		PF02359
(CDC48_N)
PF02933
(CDC48_2) 		4 ILE A 119
ASP A 118
ILE A 117
GLY A 196
 None
 0.81A 4ac9C-1cr5A:
2.6		 4ac9C-1cr5A:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d8c MALATE SYNTHASE G

(Escherichia
coli) 		PF01274
(Malate_synthase) 		4 ILE A 109
ASP A 106
ILE A 105
VAL A 100
 None
 0.79A 4ac9C-1d8cA:
2.5		 4ac9C-1d8cA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dl2 CLASS I
ALPHA-1,2-MANNOSIDAS
E

(Saccharomyces
cerevisiae) 		PF01532
(Glyco_hydro_47) 		4 ILE A  83
ASP A  86
PHE A 499
GLN A 432
 None
None
GOL  A 900 (-3.3A)
None
 0.76A 4ac9C-1dl2A:
undetectable		 4ac9C-1dl2A:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dll TETANUS TOXIN

(Clostridium
tetani) 		PF07951
(Toxin_R_bind_C)
PF07953
(Toxin_R_bind_N) 		4 ILE A 896
ILE A 891
VAL A 915
GLY A 917
 None
 0.78A 4ac9C-1dllA:
undetectable		 4ac9C-1dllA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ekq HYDROXYETHYLTHIAZOLE
KINASE

(Bacillus
subtilis) 		PF02110
(HK) 		5 ILE A 112
ASP A 110
ILE A 111
VAL A  91
GLY A  81
 None
 1.20A 4ac9C-1ekqA:
4.8		 4ac9C-1ekqA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1evj GLUCOSE-FRUCTOSE
OXIDOREDUCTASE

(Zymomonas
mobilis) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		5 ILE A  36
ILE A 105
SER A 344
GLN A 328
GLY A 155
 None
NAD  A 500 (-4.8A)
None
None
None
 1.42A 4ac9C-1evjA:
6.0		 4ac9C-1evjA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f6d UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE

(Escherichia
coli) 		PF02350
(Epimerase_2) 		4 ILE A 166
PHE A 146
SER A 103
GLY A 114
 None
 0.71A 4ac9C-1f6dA:
3.8		 4ac9C-1f6dA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g6o CAG-ALPHA

(Helicobacter
pylori) 		PF00437
(T2SSE) 		5 ILE A 168
ASP A 166
ILE A 164
VAL A 314
SER A 277
 None
 1.45A 4ac9C-1g6oA:
2.1		 4ac9C-1g6oA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gu1 3-DEHYDROQUINATE
DEHYDRATASE

(Streptomyces
coelicolor) 		PF01220
(DHquinase_II) 		5 ILE A   9
ASP A  52
ILE A  11
PHE A  53
VAL A 105
 None
 1.36A 4ac9C-1gu1A:
5.9		 4ac9C-1gu1A:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h5q NADP-DEPENDENT
MANNITOL
DEHYDROGENASE

(Agaricus
bisporus) 		PF13561
(adh_short_C2) 		4 ILE A  80
ASP A  84
ILE A  90
GLY A 142
 None
 0.78A 4ac9C-1h5qA:
4.3		 4ac9C-1h5qA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hh2 N UTILIZATION
SUBSTANCE PROTEIN A

(Thermotoga
maritima) 		PF00575
(S1)
PF08529
(NusA_N)
PF13184
(KH_5) 		4 ILE P 336
ASP P 337
ILE P 338
GLY P 319
 None
 0.79A 4ac9C-1hh2P:
undetectable		 4ac9C-1hh2P:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hsk UDP-N-ACETYLENOLPYRU
VOYLGLUCOSAMINE
REDUCTASE

(Staphylococcus
aureus) 		PF01565
(FAD_binding_4)
PF02873
(MurB_C) 		4 ILE A  91
ILE A  86
SER A 143
GLY A  81
 None
None
FAD  A 401 (-2.6A)
FAD  A 401 (-3.0A)
 0.79A 4ac9C-1hskA:
undetectable		 4ac9C-1hskA:
24.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i8q HYALURONATE LYASE

(Streptococcus
agalactiae) 		PF02278
(Lyase_8)
PF02884
(Lyase_8_C)
PF08124
(Lyase_8_N) 		4 ILE A 880
ASP A 850
ILE A 851
PHE A 822
 None
 0.72A 4ac9C-1i8qA:
undetectable		 4ac9C-1i8qA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iub FUCOSE-SPECIFIC
LECTIN

(Aleuria
aurantia) 		PF07938
(Fungal_lectin) 		4 ILE A 276
ASP A 275
ILE A 274
GLY A 220
 None
 0.67A 4ac9C-1iubA:
undetectable		 4ac9C-1iubA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k6d ACETATE
COA-TRANSFERASE
ALPHA SUBUNIT

(Escherichia
coli) 		PF01144
(CoA_trans) 		4 ILE A  61
ILE A  65
VAL A  95
GLY A  85
 None
 0.78A 4ac9C-1k6dA:
2.3		 4ac9C-1k6dA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k7y METHIONINE SYNTHASE

(Escherichia
coli) 		PF02310
(B12-binding)
PF02607
(B12-binding_2)
PF02965
(Met_synt_B12) 		4 ILE A 846
ILE A 832
VAL A 754
GLY A 805
 None
 0.75A 4ac9C-1k7yA:
2.7		 4ac9C-1k7yA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kcz BETA-METHYLASPARTASE

(Clostridium
tetanomorphum) 		PF05034
(MAAL_N)
PF07476
(MAAL_C) 		4 ILE A 237
ASP A 238
ILE A 197
GLY A 205
 None
MG  A 901 (-2.4A)
None
None
 0.84A 4ac9C-1kczA:
undetectable		 4ac9C-1kczA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kkr 3-METHYLASPARTATE
AMMONIA-LYASE

(Citrobacter
amalonaticus) 		PF05034
(MAAL_N)
PF07476
(MAAL_C) 		4 ILE A 237
ASP A 238
ILE A 197
GLY A 205
 None
MG  A 501 ( 2.6A)
None
None
 0.81A 4ac9C-1kkrA:
undetectable		 4ac9C-1kkrA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kol FORMALDEHYDE
DEHYDROGENASE

(Pseudomonas
putida) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 ILE A 367
ILE A 389
VAL A   6
GLY A  66
 None
 0.82A 4ac9C-1kolA:
2.7		 4ac9C-1kolA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kve SMK TOXIN
SMK TOXIN

(Millerozyma
farinosa;
Millerozyma
farinosa) 		no annotation
no annotation 		4 ILE A  58
ILE A  61
PHE A  65
GLY B 155
 None
 0.81A 4ac9C-1kveA:
undetectable		 4ac9C-1kveA:
8.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lj9 TRANSCRIPTIONAL
REGULATOR SLYA

(Enterococcus
faecalis) 		PF01047
(MarR) 		4 ILE A  50
ILE A  54
GLN A  32
GLY A  31
 None
 0.77A 4ac9C-1lj9A:
undetectable		 4ac9C-1lj9A:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lqt FPRA

(Mycobacterium
tuberculosis) 		PF07992
(Pyr_redox_2) 		5 ILE A 348
ILE A 341
PHE A 334
VAL A 104
GLY A 326
 None
None
None
FAD  A2457 (-3.8A)
None
 1.46A 4ac9C-1lqtA:
undetectable		 4ac9C-1lqtA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mg5 ALCOHOL
DEHYDROGENASE

(Drosophila
melanogaster) 		PF00106
(adh_short) 		4 ILE A  46
ILE A  36
SER A 215
GLY A  19
 None
 0.85A 4ac9C-1mg5A:
6.6		 4ac9C-1mg5A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mwo ALPHA AMYLASE

(Pyrococcus
woesei) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		5 ILE A 165
ASP A 145
PHE A 131
SER A  55
GLY A 114
 None
 1.13A 4ac9C-1mwoA:
2.6		 4ac9C-1mwoA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1op2 VENOM SERINE
PROTEINASE

(Deinagkistrodon
acutus) 		PF00089
(Trypsin) 		4 ILE A 103
ASP A 102
ILE A 212
GLY A  44
 None
 0.85A 4ac9C-1op2A:
undetectable		 4ac9C-1op2A:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ovl ORPHAN NUCLEAR
RECEPTOR NURR1 (MSE
496, 511)

(Homo sapiens) 		PF00104
(Hormone_recep) 		4 ILE B 587
ASP B 589
ILE B 588
GLN B 404
 None
 0.83A 4ac9C-1ovlB:
undetectable		 4ac9C-1ovlB:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pch PHOSPHOCARRIER
PROTEIN

(Mycoplasma
capricolum) 		PF00381
(PTS-HPr) 		4 ILE A  77
ILE A  63
VAL A  50
GLY A  42
 None
 0.85A 4ac9C-1pchA:
undetectable		 4ac9C-1pchA:
12.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pqs CELL DIVISION
CONTROL PROTEIN 24

(Saccharomyces
cerevisiae) 		PF00564
(PB1) 		4 ILE A 798
ILE A 795
PHE A 791
GLY A 829
 None
 0.72A 4ac9C-1pqsA:
undetectable		 4ac9C-1pqsA:
11.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pv9 XAA-PRO DIPEPTIDASE

(Pyrococcus
furiosus) 		PF00557
(Peptidase_M24)
PF01321
(Creatinase_N) 		5 ILE A  81
ILE A  78
PHE A  72
SER A  32
GLY A  40
 None
 1.40A 4ac9C-1pv9A:
undetectable		 4ac9C-1pv9A:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pyt CHYMOTRYPSINOGEN C

(Bos taurus) 		PF00089
(Trypsin) 		4 ILE D 803
ASP D 802
ILE D 912
GLY D 744
 None
 0.84A 4ac9C-1pytD:
undetectable		 4ac9C-1pytD:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pzv PROBABLE
UBIQUITIN-CONJUGATIN
G ENZYME E2-19 KDA

(Caenorhabditis
elegans) 		PF00179
(UQ_con) 		4 ILE A  81
ILE A  76
VAL A  40
GLY A  42
 None
 0.66A 4ac9C-1pzvA:
undetectable		 4ac9C-1pzvA:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q1o CELL DIVISION
CONTROL PROTEIN 24

(Saccharomyces
cerevisiae) 		PF00564
(PB1) 		4 ILE A 798
ILE A 795
PHE A 791
GLY A 829
 None
 0.75A 4ac9C-1q1oA:
undetectable		 4ac9C-1q1oA:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qcq PROTEIN (UBIQUITIN
CONJUGATING ENZYME)

(Saccharomyces
cerevisiae) 		PF00179
(UQ_con) 		4 ILE A  79
ILE A  74
SER A  21
GLY A  40
 None
 0.84A 4ac9C-1qcqA:
undetectable		 4ac9C-1qcqA:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qdl PROTEIN
(ANTHRANILATE
SYNTHASE
(TRPE-SUBUNIT))

(Sulfolobus
solfataricus) 		PF00425
(Chorismate_bind)
PF04715
(Anth_synt_I_N) 		4 ASP A  73
ILE A  74
VAL A  43
SER A  31
 None
 0.83A 4ac9C-1qdlA:
undetectable		 4ac9C-1qdlA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r4p SHIGA-LIKE TOXIN
TYPE II A SUBUNIT

(Escherichia
coli) 		PF00161
(RIP) 		5 ILE A  54
ASP A  53
VAL A 158
SER A 112
GLY A  80
 None
None
None
FMT  A3015 (-4.0A)
None
 1.36A 4ac9C-1r4pA:
undetectable		 4ac9C-1r4pA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r6b CLPA PROTEIN

(Escherichia
coli) 		PF00004
(AAA)
PF02861
(Clp_N)
PF07724
(AAA_2)
PF10431
(ClpB_D2-small) 		4 ILE X 284
ASP X 285
ILE X 250
GLY X 256
 None
MG  X 782 (-3.7A)
None
None
 0.70A 4ac9C-1r6bX:
undetectable		 4ac9C-1r6bX:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sq7 TRIOSEPHOSPHATE
ISOMERASE

(Gallus gallus) 		PF00121
(TIM) 		4 ASP A 242
ILE A 243
PHE A 240
GLY A  10
 None
 0.80A 4ac9C-1sq7A:
3.3		 4ac9C-1sq7A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t9f PROTEIN 1D10

(Caenorhabditis
elegans) 		PF02815
(MIR) 		4 ILE A  94
ASP A  92
ILE A  88
GLY A  85
 None
 0.77A 4ac9C-1t9fA:
undetectable		 4ac9C-1t9fA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tmh TRIOSEPHOSPHATE
ISOMERASE

(Escherichia
coli) 		PF00121
(TIM) 		4 ASP A 246
ILE A 247
PHE A 244
GLY A  10
 None
 0.72A 4ac9C-1tmhA:
3.1		 4ac9C-1tmhA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1to0 HYPOTHETICAL UPF0247
PROTEIN YYDA

(Bacillus
subtilis) 		PF02590
(SPOUT_MTase) 		4 ILE A  33
ILE A   3
PHE A 105
SER A  85
 None
 0.75A 4ac9C-1to0A:
undetectable		 4ac9C-1to0A:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u2e 2-HYDROXY-6-KETONONA
-2,4-DIENEDIOIC ACID
HYDROLASE

(Escherichia
coli) 		PF12697
(Abhydrolase_6) 		4 ILE A 229
VAL A 117
SER A  85
GLY A 113
 None
 0.85A 4ac9C-1u2eA:
2.8		 4ac9C-1u2eA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1un9 DIHYDROXYACETONE
KINASE

(Citrobacter
freundii) 		PF02733
(Dak1)
PF02734
(Dak2) 		4 ILE A 271
ILE A 272
SER A 194
GLY A 302
 None
 0.70A 4ac9C-1un9A:
2.4		 4ac9C-1un9A:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uyv ACETYL-COA
CARBOXYLASE

(Saccharomyces
cerevisiae) 		PF01039
(Carboxyl_trans) 		5 ILE A1949
ILE A1892
PHE A1939
SER A1865
GLY A1880
 None
 1.45A 4ac9C-1uyvA:
3.9		 4ac9C-1uyvA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v9p DNA LIGASE

(Thermus
filiformis) 		PF01653
(DNA_ligase_aden)
PF03120
(DNA_ligase_OB)
PF12826
(HHH_2)
PF14520
(HHH_5) 		4 ILE A 155
ILE A 158
VAL A 124
GLY A 136
 None
 0.74A 4ac9C-1v9pA:
undetectable		 4ac9C-1v9pA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vh0 HYPOTHETICAL UPF0247
PROTEIN
SAV0024/SA0023

(Staphylococcus
aureus) 		PF02590
(SPOUT_MTase) 		4 ILE A  33
ILE A   3
PHE A 105
SER A  85
 None
 0.84A 4ac9C-1vh0A:
undetectable		 4ac9C-1vh0A:
15.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w5f CELL DIVISION
PROTEIN FTSZ

(Thermotoga
maritima) 		PF00091
(Tubulin)
PF12327
(FtsZ_C) 		5 ILE A  99
ILE A 127
VAL A  51
SER A  63
GLY A  28
 None
 1.49A 4ac9C-1w5fA:
6.6		 4ac9C-1w5fA:
24.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wz2 LEUCYL-TRNA
SYNTHETASE

(Pyrococcus
horikoshii) 		PF00133
(tRNA-synt_1)
PF08264
(Anticodon_1) 		4 ILE A 849
ASP A 845
ILE A 964
GLN A 956
 A  C 953 ( 4.0A)
G  C 954 ( 3.3A)
G  C 954 ( 4.5A)
None
 0.84A 4ac9C-1wz2A:
undetectable		 4ac9C-1wz2A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xoc OLIGOPEPTIDE-BINDING
PROTEIN APPA

(Bacillus
subtilis) 		PF00496
(SBP_bac_5) 		5 ILE A  48
ILE A 199
VAL A 221
GLN A 195
GLY A 196
 None
 1.31A 4ac9C-1xocA:
2.4		 4ac9C-1xocA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xvt CROTONOBETAINYL-COA:
CARNITINE
COA-TRANSFERASE

(Escherichia
coli) 		PF02515
(CoA_transf_3) 		4 ILE A 196
ASP A 197
ILE A 198
GLY A  26
 None
 0.58A 4ac9C-1xvtA:
3.4		 4ac9C-1xvtA:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yns E-1 ENZYME

(Homo sapiens) 		no annotation 4 ASP A 171
ILE A 172
PHE A 164
VAL A 135
 None
 0.82A 4ac9C-1ynsA:
2.2		 4ac9C-1ynsA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zap SECRETED ASPARTIC
PROTEINASE

(Candida
albicans) 		PF00026
(Asp) 		5 ASP A  17
ILE A  18
SER A  73
GLN A  25
GLY A  21
 None
 1.33A 4ac9C-1zapA:
undetectable		 4ac9C-1zapA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zjk MANNAN-BINDING
LECTIN SERINE
PROTEASE 2

(Homo sapiens) 		PF00084
(Sushi)
PF00089
(Trypsin) 		4 ILE A 533
ASP A 532
ILE A 652
GLY A 470
 None
 0.85A 4ac9C-1zjkA:
2.9		 4ac9C-1zjkA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2asb TRANSCRIPTION
ELONGATION PROTEIN
NUSA

(Mycobacterium
tuberculosis) 		PF13184
(KH_5) 		4 ILE A 321
ASP A 322
ILE A 323
GLY A 304
 A  B  10 ( 4.6A)
U  B   9 ( 3.8A)
A  B   8 ( 3.9A)
C  B   6 ( 4.7A)
 0.84A 4ac9C-2asbA:
undetectable		 4ac9C-2asbA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2au1 IGG-DEGRADING
PROTEASE

(Streptococcus
pyogenes) 		PF09028
(Mac-1) 		5 ILE A 181
ASP A 178
ILE A 177
SER A 150
GLY A 100
 None
 1.37A 4ac9C-2au1A:
undetectable		 4ac9C-2au1A:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2az3 NUCLEOSIDE
DIPHOSPHATE KINASE

(Halobacterium
salinarum) 		PF00334
(NDK) 		5 ILE A  25
ASP A  24
ILE A  22
VAL A  74
SER A  71
 None
 1.26A 4ac9C-2az3A:
undetectable		 4ac9C-2az3A:
14.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c5q RRAA-LIKE PROTEIN
YER010C

(Saccharomyces
cerevisiae) 		PF03737
(RraA-like) 		4 ILE A 175
ASP A 173
ILE A 169
SER A 162
 None
CME  A 170 ( 3.5A)
CME  A 170 ( 3.9A)
None
 0.81A 4ac9C-2c5qA:
undetectable		 4ac9C-2c5qA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d7u ADENYLOSUCCINATE
SYNTHETASE

(Pyrococcus
horikoshii) 		PF00709
(Adenylsucc_synt) 		5 ILE A  99
ASP A 100
ILE A  70
SER A 129
GLY A  38
 None
 1.31A 4ac9C-2d7uA:
6.3		 4ac9C-2d7uA:
24.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dne DIHYDROLIPOYLLYSINE-
RESIDUE
ACETYLTRANSFERASE
COMPONENT OF
PYRUVATE
DEHYDROGENASE
COMPLEX

(Homo sapiens) 		PF00364
(Biotin_lipoyl) 		4 ILE A  41
ASP A  39
ILE A  35
GLY A  32
 None
 0.84A 4ac9C-2dneA:
undetectable		 4ac9C-2dneA:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dyu FORMAMIDASE

(Helicobacter
pylori) 		PF00795
(CN_hydrolase) 		4 ILE A  19
ILE A 253
VAL A  53
GLY A  49
 None
 0.75A 4ac9C-2dyuA:
undetectable		 4ac9C-2dyuA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ekd HYPOTHETICAL PROTEIN
PH0250

(Pyrococcus
horikoshii) 		PF03192
(DUF257) 		5 ILE A 113
ILE A  33
PHE A   6
VAL A  16
SER A 189
 None
 1.04A 4ac9C-2ekdA:
undetectable		 4ac9C-2ekdA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2esb DUAL SPECIFICITY
PROTEIN PHOSPHATASE
18

(Homo sapiens) 		PF00782
(DSPc) 		5 ASP A  84
PHE A  83
VAL A  71
SER A  74
GLN A 150
 None
 1.42A 4ac9C-2esbA:
undetectable		 4ac9C-2esbA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eyq TRANSCRIPTION-REPAIR
COUPLING FACTOR

(Escherichia
coli) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF02559
(CarD_CdnL_TRCF)
PF03461
(TRCF) 		4 ILE A1075
ILE A1087
VAL A1135
GLY A1080
 None
 0.80A 4ac9C-2eyqA:
undetectable		 4ac9C-2eyqA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f4n HYPOTHETICAL PROTEIN
MJ1651

(Methanocaldococcus
jannaschii) 		PF01887
(SAM_adeno_trans) 		4 ILE A 203
ILE A 215
PHE A 230
VAL A 255
 None
 0.72A 4ac9C-2f4nA:
3.1		 4ac9C-2f4nA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f6a COLLAGEN ADHESIN

(Staphylococcus
aureus) 		PF05737
(Collagen_bind) 		5 ILE A 207
ILE A 194
PHE A 275
VAL A 201
GLY A 270
 None
 1.30A 4ac9C-2f6aA:
undetectable		 4ac9C-2f6aA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fn9 RIBOSE ABC
TRANSPORTER,
PERIPLASMIC
RIBOSE-BINDING
PROTEIN

(Thermotoga
maritima) 		PF13407
(Peripla_BP_4) 		5 ASP A  38
ILE A   8
PHE A  16
VAL A  88
SER A 104
 None
 1.36A 4ac9C-2fn9A:
6.3		 4ac9C-2fn9A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g37 PROLINE
DEHYDROGENASE/DELTA-
1-PYRROLINE-5-CARBOX
YLATE DEHYDROGENASE

(Thermus
thermophilus) 		PF01619
(Pro_dh) 		4 ILE A  59
PHE A 129
VAL A 161
GLY A 159
 None
MPD  A 373 (-3.6A)
FAD  A2001 (-4.3A)
None
 0.82A 4ac9C-2g37A:
2.6		 4ac9C-2g37A:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g9i F420-0:GAMMA-GLUTAMY
L LIGASE

(Archaeoglobus
fulgidus) 		PF01996
(F420_ligase) 		4 ILE A 148
ILE A 165
PHE A  99
GLY A 107
 None
 0.65A 4ac9C-2g9iA:
undetectable		 4ac9C-2g9iA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gqb CONSERVED
HYPOTHETICAL PROTEIN

(Rhodopseudomonas
palustris) 		PF12200
(DUF3597) 		4 ILE A   7
ILE A  11
PHE A  12
GLY A 122
 None
 0.82A 4ac9C-2gqbA:
undetectable		 4ac9C-2gqbA:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h18 ADP-RIBOSYLATION
FACTOR-LIKE PROTEIN
8A

(Homo sapiens) 		PF00025
(Arf) 		4 ILE A 170
ASP A 168
ILE A 162
VAL A  93
 None
 0.76A 4ac9C-2h18A:
13.2		 4ac9C-2h18A:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hj1 HYPOTHETICAL PROTEIN

(Haemophilus
influenzae) 		PF03658
(Ub-RnfH) 		4 ILE A  13
ILE A  15
PHE A  30
GLN A  44
 None
 0.48A 4ac9C-2hj1A:
undetectable		 4ac9C-2hj1A:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hjh NAD-DEPENDENT
HISTONE DEACETYLASE
SIR2

(Saccharomyces
cerevisiae) 		PF02146
(SIR2)
PF04574
(DUF592) 		5 ILE A 461
ASP A 460
ILE A 457
PHE A 453
VAL A 218
 None
 1.47A 4ac9C-2hjhA:
2.9		 4ac9C-2hjhA:
24.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i04 MEMBRANE-ASSOCIATED
GUANYLATE KINASE, WW
AND PDZ
DOMAIN-CONTAINING
PROTEIN 1

(Mus musculus) 		PF00595
(PDZ) 		5 ILE A 499
ASP A 497
ILE A 478
SER A 458
GLY A 463
 None
None
None
SO4  A 901 (-3.9A)
None
 1.48A 4ac9C-2i04A:
undetectable		 4ac9C-2i04A:
12.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i34 ACID PHOSPHATASE

(Bacillus
anthracis) 		PF03767
(Acid_phosphat_B) 		4 ILE A 120
ILE A  62
PHE A 178
GLY A  44
 None
 0.70A 4ac9C-2i34A:
3.0		 4ac9C-2i34A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i6d RNA
METHYLTRANSFERASE,
TRMH FAMILY

(Porphyromonas
gingivalis) 		PF00588
(SpoU_methylase) 		5 ILE A   7
ILE A  75
PHE A  72
VAL A  64
GLY A  47
 None
 1.25A 4ac9C-2i6dA:
2.4		 4ac9C-2i6dA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i7t CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
73 KDA SUBUNIT

(Homo sapiens) 		PF00753
(Lactamase_B)
PF07521
(RMMBL)
PF10996
(Beta-Casp) 		4 ILE A  59
ASP A  60
ILE A  64
PHE A  89
 None
 0.81A 4ac9C-2i7tA:
3.2		 4ac9C-2i7tA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i9e TRIOSEPHOSPHATE
ISOMERASE

(Tenebrio
molitor) 		PF00121
(TIM) 		4 ASP A 241
ILE A 242
PHE A 239
GLY A   9
 None
 0.77A 4ac9C-2i9eA:
3.5		 4ac9C-2i9eA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jep XYLOGLUCANASE

(Paenibacillus
pabuli) 		PF00150
(Cellulase) 		4 ILE A 176
ILE A 127
VAL A 357
GLY A  45
 None
 0.79A 4ac9C-2jepA:
3.4		 4ac9C-2jepA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jet CHYMOTRYPSINOGEN B
CHAIN B
CHYMOTRYPSINOGEN B
CHAIN C

(Rattus
norvegicus;
Rattus
norvegicus) 		PF00089
(Trypsin)
PF00089
(Trypsin) 		4 ILE B 103
ASP B 102
ILE C 212
GLY B  44
 None
 0.83A 4ac9C-2jetB:
2.4		 4ac9C-2jetB:
14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jg7 ANTIQUITIN

(Acanthopagrus
schlegelii) 		PF00171
(Aldedh) 		4 ILE A 403
ILE A 385
GLN A 362
GLY A 363
 None
 0.84A 4ac9C-2jg7A:
4.1		 4ac9C-2jg7A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k24 PUTATIVE
UNCHARACTERIZED
PROTEIN TA0956

(Thermoplasma
acidophilum) 		PF11513
(TA0956) 		4 ASP A  85
ILE A  84
VAL A  79
GLY A  66
 None
 0.83A 4ac9C-2k24A:
undetectable		 4ac9C-2k24A:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2klx GLUTAREDOXIN

(Bartonella
henselae) 		PF00462
(Glutaredoxin) 		4 ILE A   4
ASP A  83
GLN A  54
GLY A  63
 None
 0.71A 4ac9C-2klxA:
undetectable		 4ac9C-2klxA:
10.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2m4l PROTEIN BT_0846

(Bacteroides
thetaiotaomicron) 		no annotation 5 ILE A  55
ILE A  12
PHE A  29
VAL A  86
SER A  90
 None
 1.21A 4ac9C-2m4lA:
undetectable		 4ac9C-2m4lA:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o2v DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 5

(Homo sapiens) 		PF00564
(PB1) 		5 ILE A  19
ASP A  30
ILE A  21
GLN A  50
GLY A  49
 None
 1.17A 4ac9C-2o2vA:
undetectable		 4ac9C-2o2vA:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ong 4S-LIMONENE SYNTHASE

(Mentha spicata) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		5 ILE A 329
ASP A 564
ILE A 328
SER A 419
GLY A 455
 None
 1.48A 4ac9C-2ongA:
undetectable		 4ac9C-2ongA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oua SERINE PROTEASE

(Nocardiopsis
alba) 		PF00089
(Trypsin) 		4 ASP A  15
ILE A  16
VAL A 106
GLY A 108
 None
 0.63A 4ac9C-2ouaA:
2.7		 4ac9C-2ouaA:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pal PARVALBUMIN

(Esox lucius) 		PF13499
(EF-hand_7) 		4 ILE A  50
ASP A  51
ILE A  58
GLY A  89
 None
MN  A 111 ( 2.9A)
None
None
 0.77A 4ac9C-2palA:
undetectable		 4ac9C-2palA:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pg8 DPGC

(Streptomyces
toyocaensis) 		PF00378
(ECH_1) 		4 ILE A 245
ASP A 190
GLN A 299
GLY A 295
 None
None
YE1  A 997 (-3.6A)
YE1  A 997 (-3.5A)
 0.83A 4ac9C-2pg8A:
2.0		 4ac9C-2pg8A:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2po4 VIRION RNA
POLYMERASE

(Escherichia
virus N4) 		no annotation 4 ILE A  12
ASP A  13
GLN A 150
GLY A  50
 None
 0.79A 4ac9C-2po4A:
undetectable		 4ac9C-2po4A:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pvs PANCREATIC
LIPASE-RELATED
PROTEIN 2

(Homo sapiens) 		PF00151
(Lipase)
PF01477
(PLAT) 		5 ILE A 372
ILE A 356
SER A 436
GLN A 445
GLY A 416
 None
 1.50A 4ac9C-2pvsA:
2.1		 4ac9C-2pvsA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q2e TYPE 2 DNA
TOPOISOMERASE 6
SUBUNIT B

(Methanosarcina
mazei) 		PF02518
(HATPase_c)
PF09239
(Topo-VIb_trans) 		4 ILE B 208
ASP B  61
ILE B  62
VAL B  42
 None
 0.82A 4ac9C-2q2eB:
undetectable		 4ac9C-2q2eB:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qvw GLP_546_48378_50642

(Giardia
intestinalis) 		PF00636
(Ribonuclease_3)
PF02170
(PAZ) 		4 ILE A 529
ASP A 528
SER A 541
GLY A 536
 None
 0.81A 4ac9C-2qvwA:
2.5		 4ac9C-2qvwA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qyg RIBULOSE
BISPHOSPHATE
CARBOXYLASE-LIKE
PROTEIN 2

(Rhodopseudomonas
palustris) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		4 ILE A 234
ILE A 196
VAL A 318
GLY A 378
 None
 0.83A 4ac9C-2qygA:
undetectable		 4ac9C-2qygA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r7m 5-FORMAMINOIMIDAZOLE
-4-CARBOXAMIDE-1-(BE
TA)-D-RIBOFURANOSYL
5'-MONOPHOSPHATE
SYNTHETASE

(Methanocaldococcus
jannaschii) 		PF06849
(DUF1246)
PF06973
(DUF1297) 		5 ILE A  78
ASP A  72
ILE A  73
PHE A  70
GLY A  25
 None
 1.38A 4ac9C-2r7mA:
undetectable		 4ac9C-2r7mA:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w0m SSO2452

(Sulfolobus
solfataricus) 		PF06745
(ATPase) 		4 ILE A 227
ASP A 220
ILE A 221
GLY A  33
 None
None
None
POP  A1240 (-3.3A)
 0.82A 4ac9C-2w0mA:
2.4		 4ac9C-2w0mA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x9p PIMD PROTEIN

(Streptomyces
natalensis) 		PF00067
(p450) 		4 ILE A 158
ASP A 209
ILE A 211
GLY A 197
 None
 0.78A 4ac9C-2x9pA:
undetectable		 4ac9C-2x9pA:
23.92