SIMILAR PATTERNS OF AMINO ACIDS FOR 4ABZ_A_T1CA1209

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lur ALDOSE 1-EPIMERASE

(Caenorhabditis
elegans) 		PF01263
(Aldose_epim) 		5 HIS A1092
ASN A1066
THR A1161
GLN A1296
LEU A1232
 None
 1.40A 4abzA-1lurA:
undetectable		 4abzA-1lurA:
21.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1qpi PROTEIN
(TETRACYCLINE
REPRESSOR)

(Escherichia
coli) 		PF00440
(TetR_N)
PF02909
(TetR_C) 		8 HIS A  64
ASN A  82
PHE A  86
HIS A 100
THR A 112
GLN A 116
LEU A 131
SER A 138
 None
None
None
IMD  A   1 (-4.0A)
None
None
None
None
 0.60A 4abzA-1qpiA:
25.4		 4abzA-1qpiA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1qpi PROTEIN
(TETRACYCLINE
REPRESSOR)

(Escherichia
coli) 		PF00440
(TetR_N)
PF02909
(TetR_C) 		6 HIS A  64
PHE A  86
GLN A 109
GLN A 116
LEU A 131
SER A 138
 None
 1.10A 4abzA-1qpiA:
25.4		 4abzA-1qpiA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1qpi PROTEIN
(TETRACYCLINE
REPRESSOR)

(Escherichia
coli) 		PF00440
(TetR_N)
PF02909
(TetR_C) 		7 HIS A  64
SER A  67
ASN A  82
PHE A  86
THR A 112
GLN A 116
LEU A 131
 None
 0.61A 4abzA-1qpiA:
25.4		 4abzA-1qpiA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t6p PHENYLALANINE
AMMONIA-LYASE

(Rhodotorula
toruloides) 		PF00221
(Lyase_aromatic) 		5 PHE A 311
ARG A 362
PRO A 364
GLN A 370
SER A 310
 None
 1.40A 4abzA-1t6pA:
1.3		 4abzA-1t6pA:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vtm COAT PROTEIN

(Tobacco mild
green mosaic
virus) 		PF00721
(TMV_coat) 		5 PHE P  35
GLN P  45
THR P  43
GLN P  47
LEU P  23
 None
 1.49A 4abzA-1vtmP:
undetectable		 4abzA-1vtmP:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xfd DIPEPTIDYL
AMINOPEPTIDASE-LIKE
PROTEIN 6

(Homo sapiens) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		5 HIS A 301
SER A 214
GLN A 243
THR A 216
LEU A 254
 None
 1.41A 4abzA-1xfdA:
0.0		 4abzA-1xfdA:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p5z TYPE VI SECRETION
SYSTEM COMPONENT

(Escherichia
coli) 		PF05954
(Phage_GPD) 		5 ARG X 372
PRO X 373
THR X  39
GLN X  36
LEU X 342
 None
 1.39A 4abzA-2p5zX:
undetectable		 4abzA-2p5zX:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cvh 25-D1.16 HEAVY CHAIN
25-D1.16 LIGHT CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 SER H  43
PHE L  97
ARG L  44
GLN L  37
LEU L  72
 None
 1.49A 4abzA-3cvhH:
undetectable		 4abzA-3cvhH:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h0l GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A

(Aquifex
aeolicus) 		PF01425
(Amidase) 		5 SER A 433
GLN A 174
THR A 396
GLN A 447
LEU A 426
 None
 1.49A 4abzA-3h0lA:
undetectable		 4abzA-3h0lA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i9v NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 4

(Thermus
thermophilus) 		PF00346
(Complex1_49kDa) 		5 HIS 4  89
ASN 4 121
HIS 4 129
THR 4 346
SER 4 286
 None
 1.28A 4abzA-3i9v4:
1.2		 4abzA-3i9v4:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q3q ALKALINE PHOSPHATASE

(Sphingomonas
sp. BSAR-1) 		PF01663
(Phosphodiest) 		5 HIS A  93
SER A  47
ARG A 101
GLN A  82
THR A 343
 None
 1.48A 4abzA-3q3qA:
1.1		 4abzA-3q3qA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uc9 INCREASED
RECOMBINATION
CENTERS PROTEIN 6

(Saccharomyces
cerevisiae) 		no annotation 5 HIS A 176
ASN A 111
PHE A 113
GLN A   7
LEU A  79
 None
 1.50A 4abzA-3uc9A:
0.0		 4abzA-3uc9A:
22.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ac0 TETRACYCLINE
REPRESSOR PROTEIN
CLASS B FROM
TRANSPOSON TN1 0

(Escherichia
coli) 		PF00440
(TetR_N)
PF02909
(TetR_C) 		9 HIS A  64
ASN A  82
PHE A  86
HIS A 100
PRO A 105
GLN A 109
THR A 112
GLN A 116
LEU A 131
 MIY  A1204 (-3.8A)
MIY  A1204 (-3.0A)
MIY  A1204 (-3.5A)
MG  A1205 ( 3.2A)
MIY  A1204 (-4.4A)
MIY  A1204 (-3.9A)
MIY  A1204 ( 4.7A)
MIY  A1204 (-2.8A)
MIY  A1204 (-4.3A)
 0.53A 4abzA-4ac0A:
26.1		 4abzA-4ac0A:
65.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ac0 TETRACYCLINE
REPRESSOR PROTEIN
CLASS B FROM
TRANSPOSON TN1 0

(Escherichia
coli) 		PF00440
(TetR_N)
PF02909
(TetR_C) 		7 PHE A  86
ARG A 104
PRO A 105
GLN A 109
THR A 112
GLN A 116
LEU A 131
 MIY  A1204 (-3.5A)
MIY  A1204 (-4.2A)
MIY  A1204 (-4.4A)
MIY  A1204 (-3.9A)
MIY  A1204 ( 4.7A)
MIY  A1204 (-2.8A)
MIY  A1204 (-4.3A)
 0.83A 4abzA-4ac0A:
26.1		 4abzA-4ac0A:
65.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bbw SIALIDASE
(NEURAMINIDASE)

(Bacteroides
thetaiotaomicron) 		PF13088
(BNR_2)
PF14873
(BNR_assoc_N) 		5 ASN A 332
GLN A 311
THR A 312
GLN A 314
LEU A 263
 None
 1.24A 4abzA-4bbwA:
undetectable		 4abzA-4bbwA:
17.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4d5c TETRACYCLINE
REPRESSOR PROTEIN
TETR

(Proteus
mirabilis) 		PF00440
(TetR_N)
PF02909
(TetR_C) 		8 HIS A  64
ASN A  82
PHE A  86
ARG A 104
PRO A 105
GLN A 109
THR A 112
GLN A 116
 None
 0.94A 4abzA-4d5cA:
26.2		 4abzA-4d5cA:
59.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4d5c TETRACYCLINE
REPRESSOR PROTEIN
TETR

(Proteus
mirabilis) 		PF00440
(TetR_N)
PF02909
(TetR_C) 		8 HIS A  64
ASN A  82
PHE A  86
HIS A 100
ARG A 104
PRO A 105
GLN A 109
GLN A 116
 None
 0.90A 4abzA-4d5cA:
26.2		 4abzA-4d5cA:
59.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4d5c TETRACYCLINE
REPRESSOR PROTEIN
TETR

(Proteus
mirabilis) 		PF00440
(TetR_N)
PF02909
(TetR_C) 		5 PHE A  86
HIS A 100
PRO A 105
GLN A 109
LEU A 117
 None
 1.11A 4abzA-4d5cA:
26.2		 4abzA-4d5cA:
59.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rl1 TYPE I POLYKETIDE
SYNTHASE AVES 1

(Streptomyces
avermitilis) 		PF00698
(Acyl_transf_1) 		5 HIS A 227
SER A 120
ASN A 276
GLN A  35
LEU A 144
 None
 1.44A 4abzA-4rl1A:
undetectable		 4abzA-4rl1A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ycr TELLURITE RESISTANCE
PROTEIN TEHA HOMOLOG

(Haemophilus
influenzae) 		PF03595
(SLAC1) 		5 SER A 153
ASN A 150
THR A 113
GLN A 116
LEU A 122
 None
 1.36A 4abzA-4ycrA:
2.3		 4abzA-4ycrA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hkj COMPLEMENT C1Q
SUBCOMPONENT SUBUNIT
A,COMPLEMENT C1Q
SUBCOMPONENT SUBUNIT
C,COMPLEMENT C1Q
SUBCOMPONENT SUBUNIT
B

(Homo sapiens) 		PF00386
(C1q) 		5 ASN A 309
PRO A 406
GLN A 277
THR A 276
LEU A 233
 None
 1.42A 4abzA-5hkjA:
undetectable		 4abzA-5hkjA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5imw INTERMEDILYSIN

(Streptococcus
intermedius) 		PF01289
(Thiol_cytolysin)
PF17440
(Thiol_cytolys_C) 		5 SER A 261
ASN A 297
PRO A 265
LEU A 133
SER A 392
 None
 1.33A 4abzA-5imwA:
undetectable		 4abzA-5imwA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j5u RAGB/SUSD DOMAIN
PROTEIN

(Flavobacterium
johnsoniae) 		PF12771
(SusD-like_2) 		5 SER A 359
PHE A 238
ARG A 135
THR A 431
GLN A 392
 None
 1.23A 4abzA-5j5uA:
undetectable		 4abzA-5j5uA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m0y CELLULOSOME
ANCHORING PROTEIN
COHESIN REGION
IG DOMAIN PROTEIN
GROUP 2 DOMAIN
PROTEIN

(Ruminiclostridium
thermocellum) 		PF00963
(Cohesin)
no annotation 		5 SER A 151
ASN B 113
PHE B 157
THR A 149
LEU A 161
 EDO  A 203 ( 4.2A)
CA  B 202 ( 4.7A)
None
None
None
 1.48A 4abzA-5m0yA:
undetectable		 4abzA-5m0yA:
22.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5mru TETRACYCLINE
REPRESSOR, CLASS A

(Pseudomonas sp.) 		no annotation 9 HIS A  64
SER A  67
ASN A  82
PHE A  86
HIS A 100
PRO A 105
THR A 112
GLN A 116
SER A 138
 TDC  A 301 (-3.8A)
TDC  A 301 (-3.3A)
TDC  A 301 (-3.2A)
TDC  A 301 (-3.3A)
MG  A 302 ( 3.2A)
TDC  A 301 (-4.5A)
None
TDC  A 301 (-2.8A)
TDC  A 301 ( 3.7A)
 0.78A 4abzA-5mruA:
23.2		 4abzA-5mruA:
47.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5mru TETRACYCLINE
REPRESSOR, CLASS A

(Pseudomonas sp.) 		no annotation 5 SER A  67
ARG A 104
PRO A 105
THR A 112
GLN A 116
 TDC  A 301 (-3.3A)
TDC  A 301 (-4.0A)
TDC  A 301 (-4.5A)
None
TDC  A 301 (-2.8A)
 1.03A 4abzA-5mruA:
23.2		 4abzA-5mruA:
47.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5udy ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 7

(Homo sapiens) 		PF01663
(Phosphodiest) 		5 HIS A  79
HIS A 247
ARG A 212
PRO A 198
LEU A  54
 None
ZN  A 501 (-3.1A)
None
None
None
 1.48A 4abzA-5udyA:
0.8		 4abzA-5udyA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6en4 SPLICING FACTOR 3B
SUBUNIT 3
SPLICING FACTOR 3B
SUBUNIT 5

(Homo sapiens) 		no annotation 5 ARG A 429
PRO A 406
THR A1103
LEU B  50
SER A  15
 None
 1.42A 4abzA-6en4A:
undetectable		 4abzA-6en4A:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6en4 SPLICING FACTOR 3B
SUBUNIT 3
SPLICING FACTOR 3B
SUBUNIT 5

(Homo sapiens) 		no annotation 5 HIS A 356
ARG A 429
THR A1103
LEU B  50
SER A  15
 None
 1.31A 4abzA-6en4A:
undetectable		 4abzA-6en4A:
16.75