SIMILAR PATTERNS OF AMINO ACIDS FOR 4A9J_C_TYLC1184_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ciy CRYIA(A)

(Bacillus
thuringiensis)
PF00555
(Endotoxin_M)
PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N)
4 VAL A 160
LEU A 148
LEU A 157
ILE A  97
None
0.88A 4a9jC-1ciyA:
1.0
4a9jC-1ciyA:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ddg SULFITE REDUCTASE
(NADPH) FLAVOPROTEIN
ALPHA-COMPONENT


(Escherichia
coli)
PF00175
(NAD_binding_1)
PF00667
(FAD_binding_1)
4 VAL A 437
LEU A 268
LEU A 263
ILE A 390
None
0.84A 4a9jC-1ddgA:
0.0
4a9jC-1ddgA:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fps FARNESYL DIPHOSPHATE
SYNTHASE


(Gallus gallus)
PF00348
(polyprenyl_synt)
4 VAL A 285
LEU A 300
LEU A 199
ASN A 279
None
0.94A 4a9jC-1fpsA:
0.5
4a9jC-1fpsA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kcz BETA-METHYLASPARTASE

(Clostridium
tetanomorphum)
PF05034
(MAAL_N)
PF07476
(MAAL_C)
4 VAL A 239
LEU A 211
LEU A 204
ILE A 258
None
0.92A 4a9jC-1kczA:
0.3
4a9jC-1kczA:
15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lns X-PROLYL DIPEPTIDYL
AMINOPEPTIDASE


(Lactococcus
lactis)
PF02129
(Peptidase_S15)
PF08530
(PepX_C)
PF09168
(PepX_N)
4 VAL A 533
LEU A 493
LEU A 535
ASN A 614
None
0.85A 4a9jC-1lnsA:
0.0
4a9jC-1lnsA:
10.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mr2 ADPR PYROPHOSPHATASE

(Mycobacterium
tuberculosis)
PF00293
(NUDIX)
4 VAL A  98
LEU A 100
LEU A  94
ILE A  57
None
0.91A 4a9jC-1mr2A:
1.4
4a9jC-1mr2A:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1no5 HYPOTHETICAL PROTEIN
HI0073


(Haemophilus
influenzae)
PF01909
(NTP_transf_2)
4 VAL A  78
LEU A  49
LEU A  80
ILE A  20
None
0.93A 4a9jC-1no5A:
undetectable
4a9jC-1no5A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qgz PROTEIN
(FERREDOXIN:NADP+
REDUCTASE)


(Nostoc sp. PCC
7119)
PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6)
4 VAL A 240
LEU A 247
LEU A 274
ILE A 260
None
0.91A 4a9jC-1qgzA:
undetectable
4a9jC-1qgzA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s7j PHENAZINE
BIOSYNTHESIS PROTEIN
PHZF FAMILY


(Enterococcus
faecalis)
PF02567
(PhzC-PhzF)
4 VAL A 175
LEU A 166
LEU A 169
ILE A 137
None
0.86A 4a9jC-1s7jA:
undetectable
4a9jC-1s7jA:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uz4 MAN5A

(Cellvibrio
mixtus)
PF00150
(Cellulase)
4 VAL A  25
LEU A 250
ASN A  78
ILE A  41
None
0.93A 4a9jC-1uz4A:
undetectable
4a9jC-1uz4A:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w8g HYPOTHETICAL UPF0001
PROTEIN YGGS


(Escherichia
coli)
PF01168
(Ala_racemase_N)
4 VAL A 152
LEU A 155
LEU A 158
ILE A 108
None
None
None
ICT  A1230 ( 4.2A)
0.79A 4a9jC-1w8gA:
undetectable
4a9jC-1w8gA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1woy METHIONYL-TRNA
SYNTHETASE


(Thermus
thermophilus)
PF00133
(tRNA-synt_1)
PF09334
(tRNA-synt_1g)
4 VAL A 267
LEU A 170
LEU A 194
ILE A 181
None
0.95A 4a9jC-1woyA:
0.2
4a9jC-1woyA:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aa4 PUTATIVE
N-ACETYLMANNOSAMINE
KINASE


(Escherichia
coli)
PF00480
(ROK)
4 VAL A 253
LEU A 268
LEU A 250
ILE A 127
None
0.95A 4a9jC-2aa4A:
undetectable
4a9jC-2aa4A:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aaz THYMIDYLATE SYNTHASE

(Cryptococcus
neoformans)
PF00303
(Thymidylat_synt)
4 VAL A 302
LEU A 280
LEU A  63
ILE A  77
None
0.83A 4a9jC-2aazA:
undetectable
4a9jC-2aazA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2awa DNA POLYMERASE III,
BETA CHAIN


(Streptococcus
pneumoniae)
PF00712
(DNA_pol3_beta)
PF02767
(DNA_pol3_beta_2)
PF02768
(DNA_pol3_beta_3)
4 VAL A  86
LEU A 106
LEU A  94
ILE A  36
None
0.92A 4a9jC-2awaA:
undetectable
4a9jC-2awaA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cb1 O-ACETYL HOMOSERINE
SULFHYDRYLASE


(Thermus
thermophilus)
PF01053
(Cys_Met_Meta_PP)
4 VAL A 389
LEU A 333
LEU A 335
ILE A 348
None
0.92A 4a9jC-2cb1A:
undetectable
4a9jC-2cb1A:
15.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dvr BROMODOMAIN-CONTAINI
NG PROTEIN 2


(Homo sapiens)
PF00439
(Bromodomain)
5 VAL A  37
LEU A  42
LEU A  44
ASN A  90
ILE A  96
None
0.41A 4a9jC-2dvrA:
21.2
4a9jC-2dvrA:
82.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ewn BIRA BIFUNCTIONAL
PROTEIN


(Escherichia
coli)
PF02237
(BPL_C)
PF03099
(BPL_LplA_LipB)
PF08279
(HTH_11)
4 VAL A 169
LEU A 179
LEU A 184
ILE A 231
None
0.85A 4a9jC-2ewnA:
undetectable
4a9jC-2ewnA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hh9 THIAMIN
PYROPHOSPHOKINASE


(Candida
albicans)
PF04263
(TPK_catalytic)
PF04265
(TPK_B1_binding)
4 VAL A 319
LEU A 268
LEU A 270
ILE A 200
None
0.88A 4a9jC-2hh9A:
undetectable
4a9jC-2hh9A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2it1 362AA LONG
HYPOTHETICAL
MALTOSE/MALTODEXTRIN
TRANSPORT
ATP-BINDING PROTEIN


(Pyrococcus
horikoshii)
PF00005
(ABC_tran)
4 VAL A 172
LEU A 161
LEU A 164
ILE A 144
None
0.86A 4a9jC-2it1A:
undetectable
4a9jC-2it1A:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kzr UBIQUITIN
THIOESTERASE OTU1


(Mus musculus)
no annotation 4 VAL A   3
LEU A  17
LEU A  61
ILE A  30
None
0.94A 4a9jC-2kzrA:
undetectable
4a9jC-2kzrA:
19.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2l5e BROMODOMAIN-CONTAINI
NG PROTEIN 3


(Mus musculus)
PF00439
(Bromodomain)
4 LEU A  68
LEU A  70
ASN A 116
ILE A 122
None
0.70A 4a9jC-2l5eA:
16.0
4a9jC-2l5eA:
77.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mbg RALA-BINDING PROTEIN
1


(Homo sapiens)
PF00620
(RhoGAP)
4 VAL A 350
LEU A 278
LEU A 279
ILE A 322
None
0.64A 4a9jC-2mbgA:
undetectable
4a9jC-2mbgA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mlb REDESIGNED UBIQUITIN

(synthetic
construct)
PF00240
(ubiquitin)
4 VAL A  18
LEU A  27
LEU A  57
ILE A  68
None
0.80A 4a9jC-2mlbA:
undetectable
4a9jC-2mlbA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2owo DNA LIGASE

(Escherichia
coli)
PF01653
(DNA_ligase_aden)
PF03119
(DNA_ligase_ZBD)
PF03120
(DNA_ligase_OB)
PF12826
(HHH_2)
PF14520
(HHH_5)
4 VAL A 444
LEU A 474
LEU A 500
ILE A 458
None
0.87A 4a9jC-2owoA:
undetectable
4a9jC-2owoA:
12.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p2s PUTATIVE
OXIDOREDUCTASE


(Pectobacterium
atrosepticum)
PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C)
4 VAL A 108
LEU A 105
LEU A  99
ILE A 317
None
0.91A 4a9jC-2p2sA:
undetectable
4a9jC-2p2sA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p5z TYPE VI SECRETION
SYSTEM COMPONENT


(Escherichia
coli)
PF05954
(Phage_GPD)
4 VAL X 173
LEU X 170
LEU X 115
ILE X 197
None
0.95A 4a9jC-2p5zX:
undetectable
4a9jC-2p5zX:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vgq SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN,MITOCHONDRIA
L
ANTIVIRAL-SIGNALING
PROTEIN


(Escherichia
coli;
Homo sapiens)
PF13416
(SBP_bac_8)
PF16739
(CARD_2)
4 VAL A 391
LEU A 453
LEU A 445
ILE A 381
None
0.68A 4a9jC-2vgqA:
undetectable
4a9jC-2vgqA:
16.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2wp1 BROMODOMAIN
TESTIS-SPECIFIC
PROTEIN


(Mus musculus)
PF00439
(Bromodomain)
4 VAL A 298
LEU A 303
LEU A 305
ASN A 351
None
0.38A 4a9jC-2wp1A:
18.1
4a9jC-2wp1A:
35.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2yek BROMODOMAIN-CONTAINI
NG PROTEIN 2


(Homo sapiens)
PF00439
(Bromodomain)
5 VAL A 103
LEU A 108
LEU A 110
ASN A 156
ILE A 162
EAM  A1188 (-4.4A)
EAM  A1188 ( 3.8A)
EAM  A1188 (-4.5A)
EAM  A1188 (-3.2A)
EAM  A1188 (-3.8A)
0.34A 4a9jC-2yekA:
21.5
4a9jC-2yekA:
99.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z51 NIFU-LIKE PROTEIN 2,
CHLOROPLAST


(Arabidopsis
thaliana)
PF01106
(NifU)
4 VAL A  39
LEU A  29
LEU A  13
ILE A  70
None
0.94A 4a9jC-2z51A:
undetectable
4a9jC-2z51A:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z8u TATA-BOX-BINDING
PROTEIN


(Methanocaldococcus
jannaschii)
PF00352
(TBP)
4 VAL A  25
LEU A  42
LEU A  22
ILE A  16
None
0.94A 4a9jC-2z8uA:
undetectable
4a9jC-2z8uA:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bfx SULFOTRANSFERASE 1C2

(Homo sapiens)
PF00685
(Sulfotransfer_1)
4 VAL A 208
LEU A 190
LEU A 127
ILE A 197
None
0.81A 4a9jC-3bfxA:
undetectable
4a9jC-3bfxA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c8w ACETOACETATE
DECARBOXYLASE ADC


(Legionella
pneumophila)
PF06314
(ADC)
4 VAL A 171
LEU A 198
LEU A 241
ILE A  73
None
0.86A 4a9jC-3c8wA:
undetectable
4a9jC-3c8wA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ctz XAA-PRO
AMINOPEPTIDASE 1


(Homo sapiens)
PF00557
(Peptidase_M24)
PF01321
(Creatinase_N)
PF16188
(Peptidase_M24_C)
PF16189
(Creatinase_N_2)
4 VAL A 247
LEU A 251
LEU A 253
ILE A 237
None
0.78A 4a9jC-3ctzA:
undetectable
4a9jC-3ctzA:
13.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dls PAS
DOMAIN-CONTAINING
SERINE/THREONINE-PRO
TEIN KINASE


(Homo sapiens)
PF00069
(Pkinase)
4 VAL A1265
LEU A1104
LEU A1100
ILE A1136
None
0.90A 4a9jC-3dlsA:
undetectable
4a9jC-3dlsA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dqq PUTATIVE TRNA
SYNTHASE


(Salmonella
enterica)
PF07005
(DUF1537)
PF17042
(DUF1357_C)
4 VAL A 389
LEU A 398
LEU A 400
ASN A  32
None
0.94A 4a9jC-3dqqA:
undetectable
4a9jC-3dqqA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e4w PUTATIVE
UNCHARACTERIZED
PROTEIN


(Mycobacterium
avium)
PF00199
(Catalase)
4 VAL A 219
LEU A 214
LEU A 210
ILE A  62
None
0.93A 4a9jC-3e4wA:
undetectable
4a9jC-3e4wA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ggr CELL CYCLE
CHECKPOINT CONTROL
PROTEIN RAD9A


(Homo sapiens)
PF04139
(Rad9)
4 VAL A  17
LEU A  38
LEU A  27
ILE A  99
None
0.92A 4a9jC-3ggrA:
undetectable
4a9jC-3ggrA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iwz CATABOLITE
ACTIVATION-LIKE
PROTEIN


(Xanthomonas
campestris)
PF00027
(cNMP_binding)
PF00325
(Crp)
4 VAL A 224
LEU A 217
LEU A 226
ILE A 164
None
0.94A 4a9jC-3iwzA:
undetectable
4a9jC-3iwzA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k1r HARMONIN
USHER SYNDROME
TYPE-1G PROTEIN


(Homo sapiens)
PF00536
(SAM_1)
PF00595
(PDZ)
4 VAL A 102
LEU B 461
LEU A 100
ILE A 137
None
0.88A 4a9jC-3k1rA:
undetectable
4a9jC-3k1rA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k2k PUTATIVE
CARBOXYPEPTIDASE


(Burkholderia
mallei)
PF00246
(Peptidase_M14)
4 VAL A 212
LEU A 148
LEU A 137
ILE A 256
None
0.89A 4a9jC-3k2kA:
undetectable
4a9jC-3k2kA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lq1 2-SUCCINYL-5-ENOLPYR
UVYL-6-HYDROXY-3-CYC
LOHEXENE-1-CARBOXYLA
TE SYNTHASE


(Listeria
monocytogenes)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N)
PF16582
(TPP_enzyme_M_2)
4 VAL A  75
LEU A 104
LEU A  77
ILE A  16
None
0.93A 4a9jC-3lq1A:
undetectable
4a9jC-3lq1A:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mal STROMAL CELL-DERIVED
FACTOR 2-LIKE
PROTEIN


(Arabidopsis
thaliana)
PF02815
(MIR)
4 VAL A 163
LEU A 148
LEU A 165
ILE A  43
None
0.93A 4a9jC-3malA:
undetectable
4a9jC-3malA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oc6 6-PHOSPHOGLUCONOLACT
ONASE


(Mycolicibacterium
smegmatis)
PF01182
(Glucosamine_iso)
4 VAL A  54
LEU A  51
LEU A  50
ILE A  39
None
0.93A 4a9jC-3oc6A:
undetectable
4a9jC-3oc6A:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oc6 6-PHOSPHOGLUCONOLACT
ONASE


(Mycolicibacterium
smegmatis)
PF01182
(Glucosamine_iso)
4 VAL A  54
LEU A  92
LEU A  51
ILE A  39
None
0.87A 4a9jC-3oc6A:
undetectable
4a9jC-3oc6A:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ov3 CURCUMIN SYNTHASE

(Curcuma longa)
PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C)
4 VAL A 301
LEU A 370
LEU A 384
ILE A  22
None
0.92A 4a9jC-3ov3A:
undetectable
4a9jC-3ov3A:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3psh PROTEIN HI_1472

(Haemophilus
influenzae)
PF01497
(Peripla_BP_2)
4 VAL A 251
LEU A 248
LEU A 214
ILE A 272
None
0.87A 4a9jC-3pshA:
undetectable
4a9jC-3pshA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rr1 PUTATIVE
D-GALACTONATE
DEHYDRATASE


(Ralstonia
pickettii)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
4 VAL A 102
LEU A 105
LEU A 106
ILE A  60
None
0.92A 4a9jC-3rr1A:
undetectable
4a9jC-3rr1A:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tsn 4-HYDROXYTHREONINE-4
-PHOSPHATE
DEHYDROGENASE


(Campylobacter
jejuni)
PF04166
(PdxA)
4 VAL A  20
LEU A  52
LEU A  45
ILE A  36
None
0.91A 4a9jC-3tsnA:
undetectable
4a9jC-3tsnA:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ttl POLYAMINE TRANSPORT
PROTEIN


(Pseudomonas
aeruginosa)
PF13416
(SBP_bac_8)
4 VAL A 128
LEU A  98
LEU A 103
ILE A  78
None
0.72A 4a9jC-3ttlA:
undetectable
4a9jC-3ttlA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC


(Dictyostelium
discoideum)
PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9)
4 VAL A4688
LEU A4705
LEU A4654
ILE A4664
None
0.94A 4a9jC-3vkgA:
undetectable
4a9jC-3vkgA:
3.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wpe TOLL-LIKE RECEPTOR 9

(Bos taurus)
PF13516
(LRR_6)
PF13855
(LRR_8)
4 VAL A 419
LEU A 397
LEU A 421
ILE A 409
None
0.93A 4a9jC-3wpeA:
undetectable
4a9jC-3wpeA:
10.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zgk AVR3A11

(Phytophthora
capsici)
PF16810
(RXLR)
4 VAL A  75
LEU A 110
LEU A 106
ILE A  82
None
0.83A 4a9jC-3zgkA:
undetectable
4a9jC-3zgkA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b6z FAMILY M14
UNASSIGNED PEPTIDASE


(Burkholderia
cenocepacia)
PF00246
(Peptidase_M14)
4 VAL A 212
LEU A 148
LEU A 137
ILE A 256
None
0.89A 4a9jC-4b6zA:
undetectable
4a9jC-4b6zA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4de9 PUTATIVE
TRANSCRIPTIONAL
REGULATOR YWTF


(Bacillus
subtilis)
PF03816
(LytR_cpsA_psr)
4 VAL A 102
LEU A  78
LEU A 235
ILE A 278
None
VTP  A 401 ( 4.5A)
VTP  A 401 (-3.7A)
VTP  A 401 (-4.9A)
0.95A 4a9jC-4de9A:
undetectable
4a9jC-4de9A:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fbq DNA REPAIR AND
TELOMERE MAINTENANCE
PROTEIN NBS1,DNA
REPAIR PROTEIN RAD32
CHIMERIC PROTEIN


(Schizosaccharomyces
pombe)
PF00149
(Metallophos)
PF04152
(Mre11_DNA_bind)
4 VAL A1127
LEU A1084
LEU A1049
ILE A1066
None
0.92A 4a9jC-4fbqA:
undetectable
4a9jC-4fbqA:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fcx DNA REPAIR PROTEIN
RAD32


(Schizosaccharomyces
pombe)
no annotation 4 VAL B 127
LEU B  84
LEU B  49
ILE B  66
None
0.86A 4a9jC-4fcxB:
undetectable
4a9jC-4fcxB:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fmz INTERNALIN

(Listeria
monocytogenes)
PF12354
(Internalin_N)
PF12799
(LRR_4)
PF13855
(LRR_8)
4 VAL A 294
LEU A 281
LEU A 303
ILE A 288
None
0.87A 4a9jC-4fmzA:
undetectable
4a9jC-4fmzA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g9k ROTENONE-INSENSITIVE
NADH-UBIQUINONE
OXIDOREDUCTASE


(Saccharomyces
cerevisiae)
PF07992
(Pyr_redox_2)
4 VAL A 147
LEU A 157
LEU A 159
ILE A 167
VAL  A 147 ( 0.6A)
LEU  A 157 ( 0.6A)
LEU  A 159 ( 0.6A)
ILE  A 167 ( 0.7A)
0.94A 4a9jC-4g9kA:
undetectable
4a9jC-4g9kA:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4glx DNA LIGASE

(Escherichia
coli)
PF01653
(DNA_ligase_aden)
PF03119
(DNA_ligase_ZBD)
PF03120
(DNA_ligase_OB)
PF12826
(HHH_2)
PF14520
(HHH_5)
4 VAL A 444
LEU A 474
LEU A 500
ILE A 458
None
0.83A 4a9jC-4glxA:
undetectable
4a9jC-4glxA:
13.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hbx BROMODOMAIN-CONTAINI
NG PROTEIN 4


(Homo sapiens)
PF00439
(Bromodomain)
5 VAL A  87
LEU A  92
LEU A  94
ASN A 140
ILE A 146
14X  A 201 (-4.7A)
14X  A 201 (-4.4A)
None
14X  A 201 (-3.1A)
14X  A 201 ( 4.0A)
0.47A 4a9jC-4hbxA:
20.0
4a9jC-4hbxA:
70.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hhr ALPHA-DIOXYGENASE

(Arabidopsis
thaliana)
PF03098
(An_peroxidase)
4 VAL A 477
LEU A 482
LEU A 479
ASN A 267
None
HEM  A 701 (-4.5A)
HEM  A 701 (-4.5A)
HEM  A 701 ( 3.4A)
0.88A 4a9jC-4hhrA:
2.7
4a9jC-4hhrA:
12.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i0o PROTEIN ELYS

(Mus musculus)
PF16687
(ELYS-bb)
4 VAL A 197
LEU A 211
LEU A 152
ILE A 193
None
0.90A 4a9jC-4i0oA:
undetectable
4a9jC-4i0oA:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i6j F-BOX/LRR-REPEAT
PROTEIN 3


(Homo sapiens)
PF12937
(F-box-like)
4 VAL B 380
LEU B 387
LEU B 416
ILE B 392
None
0.85A 4a9jC-4i6jB:
undetectable
4a9jC-4i6jB:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4inz SOLUBLE EPOXIDE
HYDROLASE


(Bacillus
megaterium)
PF00561
(Abhydrolase_1)
4 VAL A  51
LEU A  25
LEU A  23
ILE A   6
None
0.87A 4a9jC-4inzA:
undetectable
4a9jC-4inzA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k0e HEAVY METAL CATION
TRICOMPONENT EFFLUX
PUMP ZNEA(CZCA-LIKE)


(Cupriavidus
metallidurans)
PF00873
(ACR_tran)
4 VAL A  50
LEU A  92
LEU A  90
ASN A 597
None
0.89A 4a9jC-4k0eA:
2.1
4a9jC-4k0eA:
9.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nf0 PROBABLE
C4-DICARBOXYLATE-BIN
DING PROTEIN


(Pseudomonas
aeruginosa)
PF03480
(DctP)
4 VAL A 262
LEU A 240
LEU A 143
ILE A  31
None
0.93A 4a9jC-4nf0A:
undetectable
4a9jC-4nf0A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q6p CONSERVED
HYPOTHETICAL
SECRETED PROTEIN


(Helicobacter
pylori)
PF17033
(Peptidase_M99)
PF17129
(Peptidase_M99_C)
PF17130
(Peptidase_M99_m)
4 LEU A 283
LEU A 271
ASN A  57
ILE A 312
None
0.95A 4a9jC-4q6pA:
undetectable
4a9jC-4q6pA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4raa PUTATIVE EXPORTED
PROTEIN


(Bacteroides
fragilis)
PF17170
(DUF5128)
4 VAL A 182
LEU A 164
LEU A 158
ILE A 235
None
0.90A 4a9jC-4raaA:
undetectable
4a9jC-4raaA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tkm NADH-DEPENDENT
REDUCTASE FOR
4-DEOXY-L-ERYTHRO-5-
HEXOSEULOSE URONATE


(Sphingomonas
sp. A1)
PF13561
(adh_short_C2)
4 VAL A  76
LEU A  11
LEU A  89
ILE A  66
None
0.85A 4a9jC-4tkmA:
undetectable
4a9jC-4tkmA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u09 LIC12759

(Leptospira
interrogans)
PF13855
(LRR_8)
4 VAL A 313
LEU A 299
LEU A 322
ILE A 306
None
0.94A 4a9jC-4u09A:
undetectable
4a9jC-4u09A:
16.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4uyd BROMODOMAIN-CONTAINI
NG PROTEIN 4


(Homo sapiens)
PF00439
(Bromodomain)
5 VAL A  87
LEU A  92
LEU A  94
ASN A 140
ILE A 146
V1T  A1171 (-4.9A)
V1T  A1171 (-3.8A)
None
V1T  A1171 (-3.1A)
DMS  A1169 ( 4.3A)
0.37A 4a9jC-4uydA:
20.0
4a9jC-4uydA:
71.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4uyg BROMODOMAIN-CONTAINI
NG PROTEIN 2


(Homo sapiens)
PF00439
(Bromodomain)
4 VAL A 376
LEU A 381
LEU A 383
ASN A 429
73B  A1456 (-4.0A)
73B  A1456 (-4.9A)
73B  A1456 (-4.9A)
73B  A1456 (-3.3A)
0.36A 4a9jC-4uygA:
19.5
4a9jC-4uygA:
48.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w8j PESTICIDAL CRYSTAL
PROTEIN CRY1AC


(Bacillus
thuringiensis)
PF00555
(Endotoxin_M)
PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N)
4 VAL A 160
LEU A 148
LEU A 157
ILE A  97
None
0.82A 4a9jC-4w8jA:
2.9
4a9jC-4w8jA:
10.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wky BETA-KETOACYL
SYNTHASE


(Streptomyces
albus)
PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc)
4 VAL A 173
LEU A 177
LEU A 179
ILE A 259
None
0.92A 4a9jC-4wkyA:
undetectable
4a9jC-4wkyA:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xzg HELICASE-LIKE
TRANSCRIPTION FACTOR


(Homo sapiens)
PF08797
(HIRAN)
4 VAL A 160
LEU A 164
LEU A 171
ILE A 130
None
0.90A 4a9jC-4xzgA:
undetectable
4a9jC-4xzgA:
26.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4z93 BROMODOMAIN-CONTAINI
NG PROTEIN 4


(Homo sapiens)
PF00439
(Bromodomain)
4 VAL A 380
LEU A 385
LEU A 387
ASN A 433
4LD  A 501 ( 3.8A)
4LD  A 501 (-4.1A)
4LD  A 501 (-4.4A)
4LD  A 501 (-2.8A)
0.19A 4a9jC-4z93A:
19.2
4a9jC-4z93A:
37.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zdk CTP SYNTHASE

(Mycobacterium
tuberculosis)
PF00117
(GATase)
PF06418
(CTP_synth_N)
4 VAL A 272
LEU A 276
LEU A 278
ILE A 150
None
0.91A 4a9jC-4zdkA:
undetectable
4a9jC-4zdkA:
10.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zke SUPERKILLER PROTEIN
7


(Saccharomyces
cerevisiae)
PF00009
(GTP_EFTU)
4 VAL A 708
LEU A 687
LEU A 674
ILE A 659
VAL  A 708 ( 0.6A)
LEU  A 687 ( 0.6A)
LEU  A 674 ( 0.6A)
ILE  A 659 ( 0.7A)
0.84A 4a9jC-4zkeA:
undetectable
4a9jC-4zkeA:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5edj FRPC OPERON PROTEIN

(Neisseria
meningitidis)
PF06901
(FrpC)
4 VAL A  61
LEU A  77
LEU A  89
ILE A 100
None
0.89A 4a9jC-5edjA:
undetectable
4a9jC-5edjA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ez7 FLAVOENZYME PA4991

(Pseudomonas
aeruginosa)
PF01266
(DAO)
4 VAL A 201
LEU A 338
LEU A 186
ILE A 177
None
0.92A 4a9jC-5ez7A:
undetectable
4a9jC-5ez7A:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fse UREASE SUBUNIT ALPHA

(Sporosarcina
pasteurii)
PF00449
(Urease_alpha)
PF01979
(Amidohydro_1)
4 VAL C 504
LEU C 508
LEU C 510
ILE C 180
None
0.94A 4a9jC-5fseC:
undetectable
4a9jC-5fseC:
12.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hjc BROMODOMAIN-CONTAINI
NG PROTEIN 3


(Homo sapiens)
PF00439
(Bromodomain)
4 VAL A 338
LEU A 343
LEU A 345
ASN A 391
None
0.38A 4a9jC-5hjcA:
19.2
4a9jC-5hjcA:
37.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5huu ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
[UDP-FORMING]


(Candida
albicans)
PF00982
(Glyco_transf_20)
4 VAL A   9
LEU A 146
LEU A 149
ILE A  78
None
0.86A 4a9jC-5huuA:
undetectable
4a9jC-5huuA:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iy9 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB1


(Homo sapiens)
PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04990
(RNA_pol_Rpb1_7)
PF04992
(RNA_pol_Rpb1_6)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4)
4 VAL A 545
LEU A 640
LEU A 645
ILE A 595
None
0.93A 4a9jC-5iy9A:
undetectable
4a9jC-5iy9A:
5.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5khl HEMIN ABC
TRANSPORTER,
PERIPLASMIC
HEMIN-BINDING
PROTEIN HUTB


(Vibrio cholerae)
PF01497
(Peripla_BP_2)
4 VAL B  54
LEU B  58
LEU B  60
ILE B  36
None
0.94A 4a9jC-5khlB:
undetectable
4a9jC-5khlB:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lc5 NADH DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR PROTEIN
2, MITOCHONDRIAL


(Bos taurus)
PF00346
(Complex1_49kDa)
4 VAL D 184
LEU D 207
LEU D 203
ILE D 144
None
0.64A 4a9jC-5lc5D:
undetectable
4a9jC-5lc5D:
16.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5n15 BROMODOMAIN-CONTAINI
NG FACTOR 1


(Candida
albicans)
PF00439
(Bromodomain)
4 VAL A 238
LEU A 243
ASN A 291
ILE A 297
None
None
IOD  A 404 (-3.9A)
IOD  A 404 ( 4.8A)
0.62A 4a9jC-5n15A:
16.7
4a9jC-5n15A:
31.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nn8 LYSOSOMAL
ALPHA-GLUCOSIDASE


(Homo sapiens)
no annotation 4 VAL A 939
LEU A 941
LEU A 901
ILE A 885
CSO  A 938 ( 2.8A)
None
None
None
0.85A 4a9jC-5nn8A:
undetectable
4a9jC-5nn8A:
10.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5npi SINGLE CHAIN
VARIABLE FRAGMENT OF
THE NON-NEUTRALIZING
ANTIBODY DAO5


(Mus musculus)
PF07686
(V-set)
4 VAL A 116
LEU A  18
LEU A  86
ILE A  81
None
0.90A 4a9jC-5npiA:
undetectable
4a9jC-5npiA:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nxk SERINE-RICH SECRETED
CELL WALL ANCHORED
(LPXTG-MOTIF )
PROTEIN


(Lactobacillus
reuteri)
no annotation 4 VAL A 534
LEU A 536
LEU A 562
ILE A 526
None
0.94A 4a9jC-5nxkA:
undetectable
4a9jC-5nxkA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5opt RIBOSOMAL PROTEIN
S7, PUTATIVE


(Trypanosoma
cruzi)
no annotation 4 VAL Q  76
LEU Q  83
LEU Q  98
ASN Q  49
None
0.77A 4a9jC-5optQ:
undetectable
4a9jC-5optQ:
21.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5u6v BROMODOMAIN-CONTAINI
NG PROTEIN 2


(Homo sapiens)
no annotation 4 VAL A 376
LEU A 381
LEU A 383
ASN A 429
7WY  A 501 ( 4.5A)
7WY  A 501 (-4.9A)
None
7WY  A 501 (-3.4A)
0.33A 4a9jC-5u6vA:
19.5
4a9jC-5u6vA:
39.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u9n BROMO DOMAIN
CONTAINING PROTEIN


(Cryptosporidium
parvum)
PF00439
(Bromodomain)
4 VAL A 332
LEU A 338
ASN A 413
ILE A 422
BMF  A 501 (-4.2A)
BMF  A 501 ( 4.9A)
BMF  A 501 (-2.8A)
BMF  A 501 ( 4.4A)
0.77A 4a9jC-5u9nA:
15.2
4a9jC-5u9nA:
20.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5vbr BROMODOMAIN
TESTIS-SPECIFIC
PROTEIN


(Homo sapiens)
no annotation 5 VAL A  56
LEU A  61
LEU A  63
ASN A 109
ILE A 115
IBI  A 201 ( 4.6A)
IBI  A 201 (-4.2A)
IBI  A 201 (-4.9A)
IBI  A 201 (-3.3A)
IBI  A 201 ( 3.8A)
0.66A 4a9jC-5vbrA:
20.1
4a9jC-5vbrA:
55.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xog RNA POLYMERASE II
THIRD LARGEST
SUBUNIT B44, PART OF
CENTRAL CORE


(Komagataella
phaffii)
PF01000
(RNA_pol_A_bac)
PF01193
(RNA_pol_L)
4 VAL C   7
LEU C  21
LEU C  19
ILE C 248
None
0.89A 4a9jC-5xogC:
undetectable
4a9jC-5xogC:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zln TOLL-LIKE RECEPTOR 9

(Mus musculus)
no annotation 4 VAL A 420
LEU A 398
LEU A 422
ILE A 410
None
0.89A 4a9jC-5zlnA:
undetectable
4a9jC-5zlnA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cw0 CGD2_2690 PROTEIN

(Cryptosporidium
parvum)
no annotation 4 VAL A  30
LEU A  35
LEU A  37
ASN A  83
R78  A 201 (-4.5A)
R78  A 201 (-4.9A)
None
R78  A 201 (-3.3A)
0.65A 4a9jC-6cw0A:
17.9
4a9jC-6cw0A:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dne BROMODOMAIN-CONTAINI
NG PROTEIN 4


(Homo sapiens)
no annotation 5 VAL A  87
LEU A  92
LEU A  94
ASN A 140
ILE A 146
H1V  A 501 ( 4.4A)
H1V  A 501 (-4.2A)
H1V  A 501 (-4.7A)
H1V  A 501 (-3.2A)
H1V  A 501 (-3.8A)
0.40A 4a9jC-6dneA:
19.8
4a9jC-6dneA:
undetectable