SIMILAR PATTERNS OF AMINO ACIDS FOR 4A9J_C_TYLC1184
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ciy | CRYIA(A) (Bacillusthuringiensis) |
PF00555(Endotoxin_M)PF03944(Endotoxin_C)PF03945(Endotoxin_N) | 4 | VAL A 160LEU A 148LEU A 157ILE A 97 | None | 0.88A | 4a9jC-1ciyA:1.0 | 4a9jC-1ciyA:13.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ddg | SULFITE REDUCTASE(NADPH) FLAVOPROTEINALPHA-COMPONENT (Escherichiacoli) |
PF00175(NAD_binding_1)PF00667(FAD_binding_1) | 4 | VAL A 437LEU A 268LEU A 263ILE A 390 | None | 0.84A | 4a9jC-1ddgA:0.0 | 4a9jC-1ddgA:16.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1fps | FARNESYL DIPHOSPHATESYNTHASE (Gallus gallus) |
PF00348(polyprenyl_synt) | 4 | VAL A 285LEU A 300LEU A 199ASN A 279 | None | 0.94A | 4a9jC-1fpsA:0.5 | 4a9jC-1fpsA:17.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1kcz | BETA-METHYLASPARTASE (Clostridiumtetanomorphum) |
PF05034(MAAL_N)PF07476(MAAL_C) | 4 | VAL A 239LEU A 211LEU A 204ILE A 258 | None | 0.92A | 4a9jC-1kczA:0.3 | 4a9jC-1kczA:15.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1lns | X-PROLYL DIPEPTIDYLAMINOPEPTIDASE (Lactococcuslactis) |
PF02129(Peptidase_S15)PF08530(PepX_C)PF09168(PepX_N) | 4 | VAL A 533LEU A 493LEU A 535ASN A 614 | None | 0.85A | 4a9jC-1lnsA:0.0 | 4a9jC-1lnsA:10.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1mr2 | ADPR PYROPHOSPHATASE (Mycobacteriumtuberculosis) |
PF00293(NUDIX) | 4 | VAL A 98LEU A 100LEU A 94ILE A 57 | None | 0.91A | 4a9jC-1mr2A:1.4 | 4a9jC-1mr2A:17.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1no5 | HYPOTHETICAL PROTEINHI0073 (Haemophilusinfluenzae) |
PF01909(NTP_transf_2) | 4 | VAL A 78LEU A 49LEU A 80ILE A 20 | None | 0.93A | 4a9jC-1no5A:undetectable | 4a9jC-1no5A:21.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qgz | PROTEIN(FERREDOXIN:NADP+REDUCTASE) (Nostoc sp. PCC7119) |
PF00175(NAD_binding_1)PF00970(FAD_binding_6) | 4 | VAL A 240LEU A 247LEU A 274ILE A 260 | None | 0.91A | 4a9jC-1qgzA:undetectable | 4a9jC-1qgzA:19.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1s7j | PHENAZINEBIOSYNTHESIS PROTEINPHZF FAMILY (Enterococcusfaecalis) |
PF02567(PhzC-PhzF) | 4 | VAL A 175LEU A 166LEU A 169ILE A 137 | None | 0.86A | 4a9jC-1s7jA:undetectable | 4a9jC-1s7jA:15.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1uz4 | MAN5A (Cellvibriomixtus) |
PF00150(Cellulase) | 4 | VAL A 25LEU A 250ASN A 78ILE A 41 | None | 0.93A | 4a9jC-1uz4A:undetectable | 4a9jC-1uz4A:16.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1w8g | HYPOTHETICAL UPF0001PROTEIN YGGS (Escherichiacoli) |
PF01168(Ala_racemase_N) | 4 | VAL A 152LEU A 155LEU A 158ILE A 108 | NoneNoneNoneICT A1230 ( 4.2A) | 0.79A | 4a9jC-1w8gA:undetectable | 4a9jC-1w8gA:18.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1woy | METHIONYL-TRNASYNTHETASE (Thermusthermophilus) |
PF00133(tRNA-synt_1)PF09334(tRNA-synt_1g) | 4 | VAL A 267LEU A 170LEU A 194ILE A 181 | None | 0.95A | 4a9jC-1woyA:0.2 | 4a9jC-1woyA:14.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2aa4 | PUTATIVEN-ACETYLMANNOSAMINEKINASE (Escherichiacoli) |
PF00480(ROK) | 4 | VAL A 253LEU A 268LEU A 250ILE A 127 | None | 0.95A | 4a9jC-2aa4A:undetectable | 4a9jC-2aa4A:18.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2aaz | THYMIDYLATE SYNTHASE (Cryptococcusneoformans) |
PF00303(Thymidylat_synt) | 4 | VAL A 302LEU A 280LEU A 63ILE A 77 | None | 0.83A | 4a9jC-2aazA:undetectable | 4a9jC-2aazA:15.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2awa | DNA POLYMERASE III,BETA CHAIN (Streptococcuspneumoniae) |
PF00712(DNA_pol3_beta)PF02767(DNA_pol3_beta_2)PF02768(DNA_pol3_beta_3) | 4 | VAL A 86LEU A 106LEU A 94ILE A 36 | None | 0.92A | 4a9jC-2awaA:undetectable | 4a9jC-2awaA:18.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2cb1 | O-ACETYL HOMOSERINESULFHYDRYLASE (Thermusthermophilus) |
PF01053(Cys_Met_Meta_PP) | 4 | VAL A 389LEU A 333LEU A 335ILE A 348 | None | 0.92A | 4a9jC-2cb1A:undetectable | 4a9jC-2cb1A:15.14 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2dvr | BROMODOMAIN-CONTAINING PROTEIN 2 (Homo sapiens) |
PF00439(Bromodomain) | 5 | VAL A 37LEU A 42LEU A 44ASN A 90ILE A 96 | None | 0.41A | 4a9jC-2dvrA:21.2 | 4a9jC-2dvrA:82.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ewn | BIRA BIFUNCTIONALPROTEIN (Escherichiacoli) |
PF02237(BPL_C)PF03099(BPL_LplA_LipB)PF08279(HTH_11) | 4 | VAL A 169LEU A 179LEU A 184ILE A 231 | None | 0.85A | 4a9jC-2ewnA:undetectable | 4a9jC-2ewnA:20.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hh9 | THIAMINPYROPHOSPHOKINASE (Candidaalbicans) |
PF04263(TPK_catalytic)PF04265(TPK_B1_binding) | 4 | VAL A 319LEU A 268LEU A 270ILE A 200 | None | 0.88A | 4a9jC-2hh9A:undetectable | 4a9jC-2hh9A:20.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2it1 | 362AA LONGHYPOTHETICALMALTOSE/MALTODEXTRINTRANSPORTATP-BINDING PROTEIN (Pyrococcushorikoshii) |
PF00005(ABC_tran) | 4 | VAL A 172LEU A 161LEU A 164ILE A 144 | None | 0.86A | 4a9jC-2it1A:undetectable | 4a9jC-2it1A:17.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2kzr | UBIQUITINTHIOESTERASE OTU1 (Mus musculus) |
no annotation | 4 | VAL A 3LEU A 17LEU A 61ILE A 30 | None | 0.94A | 4a9jC-2kzrA:undetectable | 4a9jC-2kzrA:19.87 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2l5e | BROMODOMAIN-CONTAINING PROTEIN 3 (Mus musculus) |
PF00439(Bromodomain) | 4 | LEU A 68LEU A 70ASN A 116ILE A 122 | None | 0.70A | 4a9jC-2l5eA:16.0 | 4a9jC-2l5eA:77.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2mbg | RALA-BINDING PROTEIN1 (Homo sapiens) |
PF00620(RhoGAP) | 4 | VAL A 350LEU A 278LEU A 279ILE A 322 | None | 0.64A | 4a9jC-2mbgA:undetectable | 4a9jC-2mbgA:20.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2mlb | REDESIGNED UBIQUITIN (syntheticconstruct) |
PF00240(ubiquitin) | 4 | VAL A 18LEU A 27LEU A 57ILE A 68 | None | 0.80A | 4a9jC-2mlbA:undetectable | 4a9jC-2mlbA:18.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2owo | DNA LIGASE (Escherichiacoli) |
PF01653(DNA_ligase_aden)PF03119(DNA_ligase_ZBD)PF03120(DNA_ligase_OB)PF12826(HHH_2)PF14520(HHH_5) | 4 | VAL A 444LEU A 474LEU A 500ILE A 458 | None | 0.87A | 4a9jC-2owoA:undetectable | 4a9jC-2owoA:12.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2p2s | PUTATIVEOXIDOREDUCTASE (Pectobacteriumatrosepticum) |
PF01408(GFO_IDH_MocA)PF02894(GFO_IDH_MocA_C) | 4 | VAL A 108LEU A 105LEU A 99ILE A 317 | None | 0.91A | 4a9jC-2p2sA:undetectable | 4a9jC-2p2sA:18.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2p5z | TYPE VI SECRETIONSYSTEM COMPONENT (Escherichiacoli) |
PF05954(Phage_GPD) | 4 | VAL X 173LEU X 170LEU X 115ILE X 197 | None | 0.95A | 4a9jC-2p5zX:undetectable | 4a9jC-2p5zX:13.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vgq | SUGAR ABCTRANSPORTERSUBSTRATE-BINDINGPROTEIN,MITOCHONDRIALANTIVIRAL-SIGNALINGPROTEIN (Escherichiacoli;Homo sapiens) |
PF13416(SBP_bac_8)PF16739(CARD_2) | 4 | VAL A 391LEU A 453LEU A 445ILE A 381 | None | 0.68A | 4a9jC-2vgqA:undetectable | 4a9jC-2vgqA:16.58 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2wp1 | BROMODOMAINTESTIS-SPECIFICPROTEIN (Mus musculus) |
PF00439(Bromodomain) | 4 | VAL A 298LEU A 303LEU A 305ASN A 351 | None | 0.38A | 4a9jC-2wp1A:18.1 | 4a9jC-2wp1A:35.76 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2yek | BROMODOMAIN-CONTAINING PROTEIN 2 (Homo sapiens) |
PF00439(Bromodomain) | 5 | VAL A 103LEU A 108LEU A 110ASN A 156ILE A 162 | EAM A1188 (-4.4A)EAM A1188 ( 3.8A)EAM A1188 (-4.5A)EAM A1188 (-3.2A)EAM A1188 (-3.8A) | 0.34A | 4a9jC-2yekA:21.5 | 4a9jC-2yekA:99.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2z51 | NIFU-LIKE PROTEIN 2,CHLOROPLAST (Arabidopsisthaliana) |
PF01106(NifU) | 4 | VAL A 39LEU A 29LEU A 13ILE A 70 | None | 0.94A | 4a9jC-2z51A:undetectable | 4a9jC-2z51A:23.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2z8u | TATA-BOX-BINDINGPROTEIN (Methanocaldococcusjannaschii) |
PF00352(TBP) | 4 | VAL A 25LEU A 42LEU A 22ILE A 16 | None | 0.94A | 4a9jC-2z8uA:undetectable | 4a9jC-2z8uA:23.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bfx | SULFOTRANSFERASE 1C2 (Homo sapiens) |
PF00685(Sulfotransfer_1) | 4 | VAL A 208LEU A 190LEU A 127ILE A 197 | None | 0.81A | 4a9jC-3bfxA:undetectable | 4a9jC-3bfxA:18.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3c8w | ACETOACETATEDECARBOXYLASE ADC (Legionellapneumophila) |
PF06314(ADC) | 4 | VAL A 171LEU A 198LEU A 241ILE A 73 | None | 0.86A | 4a9jC-3c8wA:undetectable | 4a9jC-3c8wA:18.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ctz | XAA-PROAMINOPEPTIDASE 1 (Homo sapiens) |
PF00557(Peptidase_M24)PF01321(Creatinase_N)PF16188(Peptidase_M24_C)PF16189(Creatinase_N_2) | 4 | VAL A 247LEU A 251LEU A 253ILE A 237 | None | 0.78A | 4a9jC-3ctzA:undetectable | 4a9jC-3ctzA:13.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dls | PASDOMAIN-CONTAININGSERINE/THREONINE-PROTEIN KINASE (Homo sapiens) |
PF00069(Pkinase) | 4 | VAL A1265LEU A1104LEU A1100ILE A1136 | None | 0.90A | 4a9jC-3dlsA:undetectable | 4a9jC-3dlsA:20.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dqq | PUTATIVE TRNASYNTHASE (Salmonellaenterica) |
PF07005(DUF1537)PF17042(DUF1357_C) | 4 | VAL A 389LEU A 398LEU A 400ASN A 32 | None | 0.94A | 4a9jC-3dqqA:undetectable | 4a9jC-3dqqA:16.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3e4w | PUTATIVEUNCHARACTERIZEDPROTEIN (Mycobacteriumavium) |
PF00199(Catalase) | 4 | VAL A 219LEU A 214LEU A 210ILE A 62 | None | 0.93A | 4a9jC-3e4wA:undetectable | 4a9jC-3e4wA:19.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ggr | CELL CYCLECHECKPOINT CONTROLPROTEIN RAD9A (Homo sapiens) |
PF04139(Rad9) | 4 | VAL A 17LEU A 38LEU A 27ILE A 99 | None | 0.92A | 4a9jC-3ggrA:undetectable | 4a9jC-3ggrA:18.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3iwz | CATABOLITEACTIVATION-LIKEPROTEIN (Xanthomonascampestris) |
PF00027(cNMP_binding)PF00325(Crp) | 4 | VAL A 224LEU A 217LEU A 226ILE A 164 | None | 0.94A | 4a9jC-3iwzA:undetectable | 4a9jC-3iwzA:18.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3k1r | HARMONINUSHER SYNDROMETYPE-1G PROTEIN (Homo sapiens) |
PF00536(SAM_1)PF00595(PDZ) | 4 | VAL A 102LEU B 461LEU A 100ILE A 137 | None | 0.88A | 4a9jC-3k1rA:undetectable | 4a9jC-3k1rA:20.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3k2k | PUTATIVECARBOXYPEPTIDASE (Burkholderiamallei) |
PF00246(Peptidase_M14) | 4 | VAL A 212LEU A 148LEU A 137ILE A 256 | None | 0.89A | 4a9jC-3k2kA:undetectable | 4a9jC-3k2kA:18.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lq1 | 2-SUCCINYL-5-ENOLPYRUVYL-6-HYDROXY-3-CYCLOHEXENE-1-CARBOXYLATE SYNTHASE (Listeriamonocytogenes) |
PF02775(TPP_enzyme_C)PF02776(TPP_enzyme_N)PF16582(TPP_enzyme_M_2) | 4 | VAL A 75LEU A 104LEU A 77ILE A 16 | None | 0.93A | 4a9jC-3lq1A:undetectable | 4a9jC-3lq1A:14.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mal | STROMAL CELL-DERIVEDFACTOR 2-LIKEPROTEIN (Arabidopsisthaliana) |
PF02815(MIR) | 4 | VAL A 163LEU A 148LEU A 165ILE A 43 | None | 0.93A | 4a9jC-3malA:undetectable | 4a9jC-3malA:22.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3oc6 | 6-PHOSPHOGLUCONOLACTONASE (Mycolicibacteriumsmegmatis) |
PF01182(Glucosamine_iso) | 4 | VAL A 54LEU A 51LEU A 50ILE A 39 | None | 0.93A | 4a9jC-3oc6A:undetectable | 4a9jC-3oc6A:18.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3oc6 | 6-PHOSPHOGLUCONOLACTONASE (Mycolicibacteriumsmegmatis) |
PF01182(Glucosamine_iso) | 4 | VAL A 54LEU A 92LEU A 51ILE A 39 | None | 0.87A | 4a9jC-3oc6A:undetectable | 4a9jC-3oc6A:18.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ov3 | CURCUMIN SYNTHASE (Curcuma longa) |
PF00195(Chal_sti_synt_N)PF02797(Chal_sti_synt_C) | 4 | VAL A 301LEU A 370LEU A 384ILE A 22 | None | 0.92A | 4a9jC-3ov3A:undetectable | 4a9jC-3ov3A:14.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3psh | PROTEIN HI_1472 (Haemophilusinfluenzae) |
PF01497(Peripla_BP_2) | 4 | VAL A 251LEU A 248LEU A 214ILE A 272 | None | 0.87A | 4a9jC-3pshA:undetectable | 4a9jC-3pshA:17.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rr1 | PUTATIVED-GALACTONATEDEHYDRATASE (Ralstoniapickettii) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 4 | VAL A 102LEU A 105LEU A 106ILE A 60 | None | 0.92A | 4a9jC-3rr1A:undetectable | 4a9jC-3rr1A:18.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tsn | 4-HYDROXYTHREONINE-4-PHOSPHATEDEHYDROGENASE (Campylobacterjejuni) |
PF04166(PdxA) | 4 | VAL A 20LEU A 52LEU A 45ILE A 36 | None | 0.91A | 4a9jC-3tsnA:undetectable | 4a9jC-3tsnA:15.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ttl | POLYAMINE TRANSPORTPROTEIN (Pseudomonasaeruginosa) |
PF13416(SBP_bac_8) | 4 | VAL A 128LEU A 98LEU A 103ILE A 78 | None | 0.72A | 4a9jC-3ttlA:undetectable | 4a9jC-3ttlA:19.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vkg | DYNEIN HEAVY CHAIN,CYTOPLASMIC (Dictyosteliumdiscoideum) |
PF03028(Dynein_heavy)PF07728(AAA_5)PF08393(DHC_N2)PF12774(AAA_6)PF12775(AAA_7)PF12777(MT)PF12780(AAA_8)PF12781(AAA_9) | 4 | VAL A4688LEU A4705LEU A4654ILE A4664 | None | 0.94A | 4a9jC-3vkgA:undetectable | 4a9jC-3vkgA:3.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wpe | TOLL-LIKE RECEPTOR 9 (Bos taurus) |
PF13516(LRR_6)PF13855(LRR_8) | 4 | VAL A 419LEU A 397LEU A 421ILE A 409 | None | 0.93A | 4a9jC-3wpeA:undetectable | 4a9jC-3wpeA:10.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3zgk | AVR3A11 (Phytophthoracapsici) |
PF16810(RXLR) | 4 | VAL A 75LEU A 110LEU A 106ILE A 82 | None | 0.83A | 4a9jC-3zgkA:undetectable | 4a9jC-3zgkA:16.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4b6z | FAMILY M14UNASSIGNED PEPTIDASE (Burkholderiacenocepacia) |
PF00246(Peptidase_M14) | 4 | VAL A 212LEU A 148LEU A 137ILE A 256 | None | 0.89A | 4a9jC-4b6zA:undetectable | 4a9jC-4b6zA:18.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4de9 | PUTATIVETRANSCRIPTIONALREGULATOR YWTF (Bacillussubtilis) |
PF03816(LytR_cpsA_psr) | 4 | VAL A 102LEU A 78LEU A 235ILE A 278 | NoneVTP A 401 ( 4.5A)VTP A 401 (-3.7A)VTP A 401 (-4.9A) | 0.95A | 4a9jC-4de9A:undetectable | 4a9jC-4de9A:17.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fbq | DNA REPAIR ANDTELOMERE MAINTENANCEPROTEIN NBS1,DNAREPAIR PROTEIN RAD32CHIMERIC PROTEIN (Schizosaccharomycespombe) |
PF00149(Metallophos)PF04152(Mre11_DNA_bind) | 4 | VAL A1127LEU A1084LEU A1049ILE A1066 | None | 0.92A | 4a9jC-4fbqA:undetectable | 4a9jC-4fbqA:15.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fcx | DNA REPAIR PROTEINRAD32 (Schizosaccharomycespombe) |
no annotation | 4 | VAL B 127LEU B 84LEU B 49ILE B 66 | None | 0.86A | 4a9jC-4fcxB:undetectable | 4a9jC-4fcxB:15.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fmz | INTERNALIN (Listeriamonocytogenes) |
PF12354(Internalin_N)PF12799(LRR_4)PF13855(LRR_8) | 4 | VAL A 294LEU A 281LEU A 303ILE A 288 | None | 0.87A | 4a9jC-4fmzA:undetectable | 4a9jC-4fmzA:15.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4g9k | ROTENONE-INSENSITIVENADH-UBIQUINONEOXIDOREDUCTASE (Saccharomycescerevisiae) |
PF07992(Pyr_redox_2) | 4 | VAL A 147LEU A 157LEU A 159ILE A 167 | VAL A 147 ( 0.6A)LEU A 157 ( 0.6A)LEU A 159 ( 0.6A)ILE A 167 ( 0.7A) | 0.94A | 4a9jC-4g9kA:undetectable | 4a9jC-4g9kA:15.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4glx | DNA LIGASE (Escherichiacoli) |
PF01653(DNA_ligase_aden)PF03119(DNA_ligase_ZBD)PF03120(DNA_ligase_OB)PF12826(HHH_2)PF14520(HHH_5) | 4 | VAL A 444LEU A 474LEU A 500ILE A 458 | None | 0.83A | 4a9jC-4glxA:undetectable | 4a9jC-4glxA:13.14 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4hbx | BROMODOMAIN-CONTAINING PROTEIN 4 (Homo sapiens) |
PF00439(Bromodomain) | 5 | VAL A 87LEU A 92LEU A 94ASN A 140ILE A 146 | 14X A 201 (-4.7A)14X A 201 (-4.4A)None14X A 201 (-3.1A)14X A 201 ( 4.0A) | 0.47A | 4a9jC-4hbxA:20.0 | 4a9jC-4hbxA:70.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hhr | ALPHA-DIOXYGENASE (Arabidopsisthaliana) |
PF03098(An_peroxidase) | 4 | VAL A 477LEU A 482LEU A 479ASN A 267 | NoneHEM A 701 (-4.5A)HEM A 701 (-4.5A)HEM A 701 ( 3.4A) | 0.88A | 4a9jC-4hhrA:2.7 | 4a9jC-4hhrA:12.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4i0o | PROTEIN ELYS (Mus musculus) |
PF16687(ELYS-bb) | 4 | VAL A 197LEU A 211LEU A 152ILE A 193 | None | 0.90A | 4a9jC-4i0oA:undetectable | 4a9jC-4i0oA:14.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4i6j | F-BOX/LRR-REPEATPROTEIN 3 (Homo sapiens) |
PF12937(F-box-like) | 4 | VAL B 380LEU B 387LEU B 416ILE B 392 | None | 0.85A | 4a9jC-4i6jB:undetectable | 4a9jC-4i6jB:15.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4inz | SOLUBLE EPOXIDEHYDROLASE (Bacillusmegaterium) |
PF00561(Abhydrolase_1) | 4 | VAL A 51LEU A 25LEU A 23ILE A 6 | None | 0.87A | 4a9jC-4inzA:undetectable | 4a9jC-4inzA:19.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4k0e | HEAVY METAL CATIONTRICOMPONENT EFFLUXPUMP ZNEA(CZCA-LIKE) (Cupriavidusmetallidurans) |
PF00873(ACR_tran) | 4 | VAL A 50LEU A 92LEU A 90ASN A 597 | None | 0.89A | 4a9jC-4k0eA:2.1 | 4a9jC-4k0eA:9.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4nf0 | PROBABLEC4-DICARBOXYLATE-BINDING PROTEIN (Pseudomonasaeruginosa) |
PF03480(DctP) | 4 | VAL A 262LEU A 240LEU A 143ILE A 31 | None | 0.93A | 4a9jC-4nf0A:undetectable | 4a9jC-4nf0A:20.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4q6p | CONSERVEDHYPOTHETICALSECRETED PROTEIN (Helicobacterpylori) |
PF17033(Peptidase_M99)PF17129(Peptidase_M99_C)PF17130(Peptidase_M99_m) | 4 | LEU A 283LEU A 271ASN A 57ILE A 312 | None | 0.95A | 4a9jC-4q6pA:undetectable | 4a9jC-4q6pA:19.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4raa | PUTATIVE EXPORTEDPROTEIN (Bacteroidesfragilis) |
PF17170(DUF5128) | 4 | VAL A 182LEU A 164LEU A 158ILE A 235 | None | 0.90A | 4a9jC-4raaA:undetectable | 4a9jC-4raaA:19.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4tkm | NADH-DEPENDENTREDUCTASE FOR4-DEOXY-L-ERYTHRO-5-HEXOSEULOSE URONATE (Sphingomonassp. A1) |
PF13561(adh_short_C2) | 4 | VAL A 76LEU A 11LEU A 89ILE A 66 | None | 0.85A | 4a9jC-4tkmA:undetectable | 4a9jC-4tkmA:17.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4u09 | LIC12759 (Leptospirainterrogans) |
PF13855(LRR_8) | 4 | VAL A 313LEU A 299LEU A 322ILE A 306 | None | 0.94A | 4a9jC-4u09A:undetectable | 4a9jC-4u09A:16.46 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4uyd | BROMODOMAIN-CONTAINING PROTEIN 4 (Homo sapiens) |
PF00439(Bromodomain) | 5 | VAL A 87LEU A 92LEU A 94ASN A 140ILE A 146 | V1T A1171 (-4.9A)V1T A1171 (-3.8A)NoneV1T A1171 (-3.1A)DMS A1169 ( 4.3A) | 0.37A | 4a9jC-4uydA:20.0 | 4a9jC-4uydA:71.43 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4uyg | BROMODOMAIN-CONTAINING PROTEIN 2 (Homo sapiens) |
PF00439(Bromodomain) | 4 | VAL A 376LEU A 381LEU A 383ASN A 429 | 73B A1456 (-4.0A)73B A1456 (-4.9A)73B A1456 (-4.9A)73B A1456 (-3.3A) | 0.36A | 4a9jC-4uygA:19.5 | 4a9jC-4uygA:48.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4w8j | PESTICIDAL CRYSTALPROTEIN CRY1AC (Bacillusthuringiensis) |
PF00555(Endotoxin_M)PF03944(Endotoxin_C)PF03945(Endotoxin_N) | 4 | VAL A 160LEU A 148LEU A 157ILE A 97 | None | 0.82A | 4a9jC-4w8jA:2.9 | 4a9jC-4w8jA:10.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wky | BETA-KETOACYLSYNTHASE (Streptomycesalbus) |
PF00109(ketoacyl-synt)PF02801(Ketoacyl-synt_C)PF16197(KAsynt_C_assoc) | 4 | VAL A 173LEU A 177LEU A 179ILE A 259 | None | 0.92A | 4a9jC-4wkyA:undetectable | 4a9jC-4wkyA:11.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xzg | HELICASE-LIKETRANSCRIPTION FACTOR (Homo sapiens) |
PF08797(HIRAN) | 4 | VAL A 160LEU A 164LEU A 171ILE A 130 | None | 0.90A | 4a9jC-4xzgA:undetectable | 4a9jC-4xzgA:26.09 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4z93 | BROMODOMAIN-CONTAINING PROTEIN 4 (Homo sapiens) |
PF00439(Bromodomain) | 4 | VAL A 380LEU A 385LEU A 387ASN A 433 | 4LD A 501 ( 3.8A)4LD A 501 (-4.1A)4LD A 501 (-4.4A)4LD A 501 (-2.8A) | 0.19A | 4a9jC-4z93A:19.2 | 4a9jC-4z93A:37.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zdk | CTP SYNTHASE (Mycobacteriumtuberculosis) |
PF00117(GATase)PF06418(CTP_synth_N) | 4 | VAL A 272LEU A 276LEU A 278ILE A 150 | None | 0.91A | 4a9jC-4zdkA:undetectable | 4a9jC-4zdkA:10.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zke | SUPERKILLER PROTEIN7 (Saccharomycescerevisiae) |
PF00009(GTP_EFTU) | 4 | VAL A 708LEU A 687LEU A 674ILE A 659 | VAL A 708 ( 0.6A)LEU A 687 ( 0.6A)LEU A 674 ( 0.6A)ILE A 659 ( 0.7A) | 0.84A | 4a9jC-4zkeA:undetectable | 4a9jC-4zkeA:15.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5edj | FRPC OPERON PROTEIN (Neisseriameningitidis) |
PF06901(FrpC) | 4 | VAL A 61LEU A 77LEU A 89ILE A 100 | None | 0.89A | 4a9jC-5edjA:undetectable | 4a9jC-5edjA:23.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ez7 | FLAVOENZYME PA4991 (Pseudomonasaeruginosa) |
PF01266(DAO) | 4 | VAL A 201LEU A 338LEU A 186ILE A 177 | None | 0.92A | 4a9jC-5ez7A:undetectable | 4a9jC-5ez7A:15.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fse | UREASE SUBUNIT ALPHA (Sporosarcinapasteurii) |
PF00449(Urease_alpha)PF01979(Amidohydro_1) | 4 | VAL C 504LEU C 508LEU C 510ILE C 180 | None | 0.94A | 4a9jC-5fseC:undetectable | 4a9jC-5fseC:12.21 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5hjc | BROMODOMAIN-CONTAINING PROTEIN 3 (Homo sapiens) |
PF00439(Bromodomain) | 4 | VAL A 338LEU A 343LEU A 345ASN A 391 | None | 0.38A | 4a9jC-5hjcA:19.2 | 4a9jC-5hjcA:37.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5huu | ALPHA,ALPHA-TREHALOSE-PHOSPHATE SYNTHASE[UDP-FORMING] (Candidaalbicans) |
PF00982(Glyco_transf_20) | 4 | VAL A 9LEU A 146LEU A 149ILE A 78 | None | 0.86A | 4a9jC-5huuA:undetectable | 4a9jC-5huuA:13.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5iy9 | DNA-DIRECTED RNAPOLYMERASE IISUBUNIT RPB1 (Homo sapiens) |
PF00623(RNA_pol_Rpb1_2)PF04983(RNA_pol_Rpb1_3)PF04990(RNA_pol_Rpb1_7)PF04992(RNA_pol_Rpb1_6)PF04997(RNA_pol_Rpb1_1)PF04998(RNA_pol_Rpb1_5)PF05000(RNA_pol_Rpb1_4) | 4 | VAL A 545LEU A 640LEU A 645ILE A 595 | None | 0.93A | 4a9jC-5iy9A:undetectable | 4a9jC-5iy9A:5.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5khl | HEMIN ABCTRANSPORTER,PERIPLASMICHEMIN-BINDINGPROTEIN HUTB (Vibrio cholerae) |
PF01497(Peripla_BP_2) | 4 | VAL B 54LEU B 58LEU B 60ILE B 36 | None | 0.94A | 4a9jC-5khlB:undetectable | 4a9jC-5khlB:21.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5lc5 | NADH DEHYDROGENASE[UBIQUINONE]IRON-SULFUR PROTEIN2, MITOCHONDRIAL (Bos taurus) |
PF00346(Complex1_49kDa) | 4 | VAL D 184LEU D 207LEU D 203ILE D 144 | None | 0.64A | 4a9jC-5lc5D:undetectable | 4a9jC-5lc5D:16.94 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5n15 | BROMODOMAIN-CONTAINING FACTOR 1 (Candidaalbicans) |
PF00439(Bromodomain) | 4 | VAL A 238LEU A 243ASN A 291ILE A 297 | NoneNoneIOD A 404 (-3.9A)IOD A 404 ( 4.8A) | 0.62A | 4a9jC-5n15A:16.7 | 4a9jC-5n15A:31.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5nn8 | LYSOSOMALALPHA-GLUCOSIDASE (Homo sapiens) |
no annotation | 4 | VAL A 939LEU A 941LEU A 901ILE A 885 | CSO A 938 ( 2.8A)NoneNoneNone | 0.85A | 4a9jC-5nn8A:undetectable | 4a9jC-5nn8A:10.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5npi | SINGLE CHAINVARIABLE FRAGMENT OFTHE NON-NEUTRALIZINGANTIBODY DAO5 (Mus musculus) |
PF07686(V-set) | 4 | VAL A 116LEU A 18LEU A 86ILE A 81 | None | 0.90A | 4a9jC-5npiA:undetectable | 4a9jC-5npiA:15.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5nxk | SERINE-RICH SECRETEDCELL WALL ANCHORED(LPXTG-MOTIF )PROTEIN (Lactobacillusreuteri) |
no annotation | 4 | VAL A 534LEU A 536LEU A 562ILE A 526 | None | 0.94A | 4a9jC-5nxkA:undetectable | 4a9jC-5nxkA:19.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5opt | RIBOSOMAL PROTEINS7, PUTATIVE (Trypanosomacruzi) |
no annotation | 4 | VAL Q 76LEU Q 83LEU Q 98ASN Q 49 | None | 0.77A | 4a9jC-5optQ:undetectable | 4a9jC-5optQ:21.30 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5u6v | BROMODOMAIN-CONTAINING PROTEIN 2 (Homo sapiens) |
no annotation | 4 | VAL A 376LEU A 381LEU A 383ASN A 429 | 7WY A 501 ( 4.5A)7WY A 501 (-4.9A)None7WY A 501 (-3.4A) | 0.33A | 4a9jC-5u6vA:19.5 | 4a9jC-5u6vA:39.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5u9n | BROMO DOMAINCONTAINING PROTEIN (Cryptosporidiumparvum) |
PF00439(Bromodomain) | 4 | VAL A 332LEU A 338ASN A 413ILE A 422 | BMF A 501 (-4.2A)BMF A 501 ( 4.9A)BMF A 501 (-2.8A)BMF A 501 ( 4.4A) | 0.77A | 4a9jC-5u9nA:15.2 | 4a9jC-5u9nA:20.88 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5vbr | BROMODOMAINTESTIS-SPECIFICPROTEIN (Homo sapiens) |
no annotation | 5 | VAL A 56LEU A 61LEU A 63ASN A 109ILE A 115 | IBI A 201 ( 4.6A)IBI A 201 (-4.2A)IBI A 201 (-4.9A)IBI A 201 (-3.3A)IBI A 201 ( 3.8A) | 0.66A | 4a9jC-5vbrA:20.1 | 4a9jC-5vbrA:55.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xog | RNA POLYMERASE IITHIRD LARGESTSUBUNIT B44, PART OFCENTRAL CORE (Komagataellaphaffii) |
PF01000(RNA_pol_A_bac)PF01193(RNA_pol_L) | 4 | VAL C 7LEU C 21LEU C 19ILE C 248 | None | 0.89A | 4a9jC-5xogC:undetectable | 4a9jC-5xogC:16.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5zln | TOLL-LIKE RECEPTOR 9 (Mus musculus) |
no annotation | 4 | VAL A 420LEU A 398LEU A 422ILE A 410 | None | 0.89A | 4a9jC-5zlnA:undetectable | 4a9jC-5zlnA:21.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6cw0 | CGD2_2690 PROTEIN (Cryptosporidiumparvum) |
no annotation | 4 | VAL A 30LEU A 35LEU A 37ASN A 83 | R78 A 201 (-4.5A)R78 A 201 (-4.9A)NoneR78 A 201 (-3.3A) | 0.65A | 4a9jC-6cw0A:17.9 | 4a9jC-6cw0A:23.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6dne | BROMODOMAIN-CONTAINING PROTEIN 4 (Homo sapiens) |
no annotation | 5 | VAL A 87LEU A 92LEU A 94ASN A 140ILE A 146 | H1V A 501 ( 4.4A)H1V A 501 (-4.2A)H1V A 501 (-4.7A)H1V A 501 (-3.2A)H1V A 501 (-3.8A) | 0.40A | 4a9jC-6dneA:19.8 | 4a9jC-6dneA:undetectable |