SIMILAR PATTERNS OF AMINO ACIDS FOR 4A9J_B_TYLB1187

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ciy CRYIA(A)

(Bacillus
thuringiensis) 		PF00555
(Endotoxin_M)
PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N) 		4 VAL A 160
LEU A 148
LEU A 157
ILE A  97
 None
 0.87A 4a9jB-1ciyA:
2.6		 4a9jB-1ciyA:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ddg SULFITE REDUCTASE
(NADPH) FLAVOPROTEIN
ALPHA-COMPONENT

(Escherichia
coli) 		PF00175
(NAD_binding_1)
PF00667
(FAD_binding_1) 		4 VAL A 437
LEU A 268
LEU A 263
ILE A 390
 None
 0.89A 4a9jB-1ddgA:
0.0		 4a9jB-1ddgA:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fps FARNESYL DIPHOSPHATE
SYNTHASE

(Gallus gallus) 		PF00348
(polyprenyl_synt) 		4 VAL A 285
LEU A 300
LEU A 199
ASN A 279
 None
 0.94A 4a9jB-1fpsA:
0.0		 4a9jB-1fpsA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lns X-PROLYL DIPEPTIDYL
AMINOPEPTIDASE

(Lactococcus
lactis) 		PF02129
(Peptidase_S15)
PF08530
(PepX_C)
PF09168
(PepX_N) 		4 VAL A 533
LEU A 493
LEU A 535
ASN A 614
 None
 0.82A 4a9jB-1lnsA:
0.0		 4a9jB-1lnsA:
10.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1no5 HYPOTHETICAL PROTEIN
HI0073

(Haemophilus
influenzae) 		PF01909
(NTP_transf_2) 		4 VAL A  78
LEU A  49
LEU A  80
ILE A  20
 None
 0.88A 4a9jB-1no5A:
undetectable		 4a9jB-1no5A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qgz PROTEIN
(FERREDOXIN:NADP+
REDUCTASE)

(Nostoc sp. PCC
7119) 		PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6) 		4 VAL A 240
LEU A 247
LEU A 274
ILE A 260
 None
 0.93A 4a9jB-1qgzA:
undetectable		 4a9jB-1qgzA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w8g HYPOTHETICAL UPF0001
PROTEIN YGGS

(Escherichia
coli) 		PF01168
(Ala_racemase_N) 		4 VAL A 152
LEU A 155
LEU A 158
ILE A 108
 None
None
None
ICT  A1230 ( 4.2A)
 0.89A 4a9jB-1w8gA:
undetectable		 4a9jB-1w8gA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aa4 PUTATIVE
N-ACETYLMANNOSAMINE
KINASE

(Escherichia
coli) 		PF00480
(ROK) 		4 VAL A 253
LEU A 268
LEU A 250
ILE A 127
 None
 0.87A 4a9jB-2aa4A:
undetectable		 4a9jB-2aa4A:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aaz THYMIDYLATE SYNTHASE

(Cryptococcus
neoformans) 		PF00303
(Thymidylat_synt) 		4 VAL A 302
LEU A 280
LEU A  63
ILE A  77
 None
 0.85A 4a9jB-2aazA:
undetectable		 4a9jB-2aazA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bdw HYPOTHETICAL PROTEIN
K11E8.1D

(Caenorhabditis
elegans) 		PF00069
(Pkinase) 		4 VAL A 152
LEU A  97
LEU A 141
ILE A 116
 None
 0.94A 4a9jB-2bdwA:
undetectable		 4a9jB-2bdwA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bv2 CIONA
BETAGAMMA-CRYSTALLIN

(Ciona
intestinalis) 		PF00030
(Crystall) 		4 VAL A  34
LEU A  77
LEU A  25
ILE A   3
 None
 0.91A 4a9jB-2bv2A:
undetectable		 4a9jB-2bv2A:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cb1 O-ACETYL HOMOSERINE
SULFHYDRYLASE

(Thermus
thermophilus) 		PF01053
(Cys_Met_Meta_PP) 		4 VAL A 389
LEU A 333
LEU A 335
ILE A 348
 None
 0.87A 4a9jB-2cb1A:
undetectable		 4a9jB-2cb1A:
15.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dvr BROMODOMAIN-CONTAINI
NG PROTEIN 2

(Homo sapiens) 		PF00439
(Bromodomain) 		5 VAL A  37
LEU A  42
LEU A  44
ASN A  90
ILE A  96
 None
 0.39A 4a9jB-2dvrA:
23.2		 4a9jB-2dvrA:
82.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e0z VIRUS-LIKE PARTICLE

(Pyrococcus
furiosus) 		PF04454
(Linocin_M18) 		4 VAL A 204
LEU A 130
LEU A 134
ILE A 294
 None
 0.93A 4a9jB-2e0zA:
undetectable		 4a9jB-2e0zA:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ewn BIRA BIFUNCTIONAL
PROTEIN

(Escherichia
coli) 		PF02237
(BPL_C)
PF03099
(BPL_LplA_LipB)
PF08279
(HTH_11) 		4 VAL A 169
LEU A 179
LEU A 184
ILE A 231
 None
 0.90A 4a9jB-2ewnA:
undetectable		 4a9jB-2ewnA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fmt METHIONYL-TRNA FMET
FORMYLTRANSFERASE

(Escherichia
coli) 		PF00551
(Formyl_trans_N)
PF02911
(Formyl_trans_C) 		4 VAL A  98
LEU A  94
LEU A  68
ILE A   7
 None
 0.95A 4a9jB-2fmtA:
undetectable		 4a9jB-2fmtA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gqt UDP-N-ACETYLENOLPYRU
VYLGLUCOSAMINE
REDUCTASE

(Thermus
caldophilus) 		PF01565
(FAD_binding_4)
PF02873
(MurB_C) 		4 VAL A 253
LEU A 257
LEU A 259
ASN A 233
 None
 0.94A 4a9jB-2gqtA:
undetectable		 4a9jB-2gqtA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hh9 THIAMIN
PYROPHOSPHOKINASE

(Candida
albicans) 		PF04263
(TPK_catalytic)
PF04265
(TPK_B1_binding) 		4 VAL A 319
LEU A 268
LEU A 270
ILE A 200
 None
 0.91A 4a9jB-2hh9A:
undetectable		 4a9jB-2hh9A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kzr UBIQUITIN
THIOESTERASE OTU1

(Mus musculus) 		no annotation 4 VAL A   3
LEU A  17
LEU A  61
ILE A  30
 None
 0.94A 4a9jB-2kzrA:
undetectable		 4a9jB-2kzrA:
19.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2l5e BROMODOMAIN-CONTAINI
NG PROTEIN 3

(Mus musculus) 		PF00439
(Bromodomain) 		4 LEU A  68
LEU A  70
ASN A 116
ILE A 122
 None
 0.78A 4a9jB-2l5eA:
17.4		 4a9jB-2l5eA:
77.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mbg RALA-BINDING PROTEIN
1

(Homo sapiens) 		PF00620
(RhoGAP) 		4 VAL A 350
LEU A 278
LEU A 279
ILE A 322
 None
 0.58A 4a9jB-2mbgA:
2.0		 4a9jB-2mbgA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mlb REDESIGNED UBIQUITIN

(synthetic
construct) 		PF00240
(ubiquitin) 		4 VAL A  18
LEU A  27
LEU A  57
ILE A  68
 None
 0.78A 4a9jB-2mlbA:
undetectable		 4a9jB-2mlbA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o6q VARIABLE LYMPHOCYTE
RECEPTOR A

(Eptatretus
burgeri) 		PF13855
(LRR_8) 		4 VAL A 114
LEU A  95
LEU A 119
ILE A 102
 None
 0.93A 4a9jB-2o6qA:
undetectable		 4a9jB-2o6qA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2owo DNA LIGASE

(Escherichia
coli) 		PF01653
(DNA_ligase_aden)
PF03119
(DNA_ligase_ZBD)
PF03120
(DNA_ligase_OB)
PF12826
(HHH_2)
PF14520
(HHH_5) 		4 VAL A 444
LEU A 474
LEU A 500
ILE A 458
 None
 0.82A 4a9jB-2owoA:
undetectable		 4a9jB-2owoA:
12.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p2s PUTATIVE
OXIDOREDUCTASE

(Pectobacterium
atrosepticum) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		4 VAL A 108
LEU A 105
LEU A  99
ILE A 317
 None
 0.86A 4a9jB-2p2sA:
undetectable		 4a9jB-2p2sA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vgq SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN,MITOCHONDRIA
L
ANTIVIRAL-SIGNALING
PROTEIN

(Escherichia
coli;
Homo sapiens) 		PF13416
(SBP_bac_8)
PF16739
(CARD_2) 		4 VAL A 391
LEU A 453
LEU A 445
ILE A 381
 None
 0.61A 4a9jB-2vgqA:
2.9		 4a9jB-2vgqA:
16.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2wp1 BROMODOMAIN
TESTIS-SPECIFIC
PROTEIN

(Mus musculus) 		PF00439
(Bromodomain) 		4 VAL A 298
LEU A 303
LEU A 305
ASN A 351
 None
 0.43A 4a9jB-2wp1A:
18.2		 4a9jB-2wp1A:
35.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yb5 PUTATIVE FUSIDIC
ACID RESISTANCE
PROTEIN

(Staphylococcus
aureus) 		PF07299
(EF-G-binding_N)
PF16571
(FBP_C) 		4 VAL A  12
LEU A  74
LEU A  77
ILE A  60
 None
 0.91A 4a9jB-2yb5A:
undetectable		 4a9jB-2yb5A:
22.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2yek BROMODOMAIN-CONTAINI
NG PROTEIN 2

(Homo sapiens) 		PF00439
(Bromodomain) 		5 VAL A 103
LEU A 108
LEU A 110
ASN A 156
ILE A 162
 EAM  A1188 (-4.4A)
EAM  A1188 ( 3.8A)
EAM  A1188 (-4.5A)
EAM  A1188 (-3.2A)
EAM  A1188 (-3.8A)
 0.43A 4a9jB-2yekA:
22.6		 4a9jB-2yekA:
99.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z51 NIFU-LIKE PROTEIN 2,
CHLOROPLAST

(Arabidopsis
thaliana) 		PF01106
(NifU) 		4 VAL A  39
LEU A  29
LEU A  13
ILE A  70
 None
 0.95A 4a9jB-2z51A:
undetectable		 4a9jB-2z51A:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bfx SULFOTRANSFERASE 1C2

(Homo sapiens) 		PF00685
(Sulfotransfer_1) 		4 VAL A 208
LEU A 190
LEU A 127
ILE A 197
 None
 0.95A 4a9jB-3bfxA:
undetectable		 4a9jB-3bfxA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c8w ACETOACETATE
DECARBOXYLASE ADC

(Legionella
pneumophila) 		PF06314
(ADC) 		4 VAL A 171
LEU A 198
LEU A 241
ILE A  73
 None
 0.90A 4a9jB-3c8wA:
undetectable		 4a9jB-3c8wA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cdk SUCCINYL-COA:3-KETOA
CID-COENZYME A
TRANSFERASE SUBUNIT
A

(Bacillus
subtilis) 		PF01144
(CoA_trans) 		4 VAL A  51
LEU A  63
LEU A  66
ILE A 155
 None
 0.91A 4a9jB-3cdkA:
undetectable		 4a9jB-3cdkA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ctz XAA-PRO
AMINOPEPTIDASE 1

(Homo sapiens) 		PF00557
(Peptidase_M24)
PF01321
(Creatinase_N)
PF16188
(Peptidase_M24_C)
PF16189
(Creatinase_N_2) 		4 VAL A 247
LEU A 251
LEU A 253
ILE A 237
 None
 0.78A 4a9jB-3ctzA:
undetectable		 4a9jB-3ctzA:
13.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dls PAS
DOMAIN-CONTAINING
SERINE/THREONINE-PRO
TEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL A1265
LEU A1104
LEU A1100
ILE A1136
 None
 0.89A 4a9jB-3dlsA:
undetectable		 4a9jB-3dlsA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dqq PUTATIVE TRNA
SYNTHASE

(Salmonella
enterica) 		PF07005
(DUF1537)
PF17042
(DUF1357_C) 		4 VAL A 389
LEU A 398
LEU A 400
ASN A  32
 None
 0.90A 4a9jB-3dqqA:
undetectable		 4a9jB-3dqqA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ggr CELL CYCLE
CHECKPOINT CONTROL
PROTEIN RAD9A

(Homo sapiens) 		PF04139
(Rad9) 		4 VAL A  17
LEU A  38
LEU A  27
ILE A  99
 None
 0.95A 4a9jB-3ggrA:
undetectable		 4a9jB-3ggrA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h0g DNA-DIRECTED RNA
POLYMERASES I, II,
AND III SUBUNIT
RPABC1

(Schizosaccharomyces
pombe) 		PF01191
(RNA_pol_Rpb5_C)
PF03871
(RNA_pol_Rpb5_N) 		4 VAL E 179
LEU E 183
LEU E 185
ILE E 193
 None
 0.95A 4a9jB-3h0gE:
undetectable		 4a9jB-3h0gE:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k2k PUTATIVE
CARBOXYPEPTIDASE

(Burkholderia
mallei) 		PF00246
(Peptidase_M14) 		4 VAL A 212
LEU A 148
LEU A 137
ILE A 256
 None
 0.85A 4a9jB-3k2kA:
undetectable		 4a9jB-3k2kA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k8i 30KLP

(Treponema
pallidum) 		no annotation 4 VAL A 187
LEU A  48
LEU A 189
ILE A 277
 None
 0.86A 4a9jB-3k8iA:
undetectable		 4a9jB-3k8iA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l9y SUPEROXIDE DISMUTASE
[CU-ZN]

(Bombyx mori) 		PF00080
(Sod_Cu) 		4 VAL A  17
LEU A 117
LEU A   9
ILE A  86
 None
 0.93A 4a9jB-3l9yA:
undetectable		 4a9jB-3l9yA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lq1 2-SUCCINYL-5-ENOLPYR
UVYL-6-HYDROXY-3-CYC
LOHEXENE-1-CARBOXYLA
TE SYNTHASE

(Listeria
monocytogenes) 		PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N)
PF16582
(TPP_enzyme_M_2) 		4 VAL A  75
LEU A 104
LEU A  77
ILE A  16
 None
 0.82A 4a9jB-3lq1A:
undetectable		 4a9jB-3lq1A:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mal STROMAL CELL-DERIVED
FACTOR 2-LIKE
PROTEIN

(Arabidopsis
thaliana) 		PF02815
(MIR) 		4 VAL A 163
LEU A 148
LEU A 165
ILE A  43
 None
 0.94A 4a9jB-3malA:
undetectable		 4a9jB-3malA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n7x CAPSID PROTEIN

(Decapod
penstyldensovirus
1) 		PF16530
(IHHNV_capsid) 		4 VAL A 113
LEU A 293
LEU A 291
ILE A 225
 None
 0.92A 4a9jB-3n7xA:
undetectable		 4a9jB-3n7xA:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oc6 6-PHOSPHOGLUCONOLACT
ONASE

(Mycolicibacterium
smegmatis) 		PF01182
(Glucosamine_iso) 		4 VAL A  54
LEU A  51
LEU A  50
ILE A  39
 None
 0.85A 4a9jB-3oc6A:
undetectable		 4a9jB-3oc6A:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oc6 6-PHOSPHOGLUCONOLACT
ONASE

(Mycolicibacterium
smegmatis) 		PF01182
(Glucosamine_iso) 		4 VAL A  54
LEU A  92
LEU A  51
ILE A  39
 None
 0.90A 4a9jB-3oc6A:
undetectable		 4a9jB-3oc6A:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oep PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0988

(Thermus
thermophilus) 		PF02626
(CT_A_B)
PF02682
(CT_C_D) 		4 VAL A 445
LEU A 408
LEU A 394
ILE A 489
 None
 0.92A 4a9jB-3oepA:
undetectable		 4a9jB-3oepA:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pr6 TRAPP-ASSOCIATED
PROTEIN TCA17

(Saccharomyces
cerevisiae) 		PF04628
(Sedlin_N) 		4 VAL A   8
LEU A  10
LEU A  19
ILE A 115
 None
 0.92A 4a9jB-3pr6A:
undetectable		 4a9jB-3pr6A:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3psh PROTEIN HI_1472

(Haemophilus
influenzae) 		PF01497
(Peripla_BP_2) 		4 VAL A 251
LEU A 248
LEU A 214
ILE A 272
 None
 0.76A 4a9jB-3pshA:
undetectable		 4a9jB-3pshA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rr1 PUTATIVE
D-GALACTONATE
DEHYDRATASE

(Ralstonia
pickettii) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 VAL A 102
LEU A 105
LEU A 106
ILE A  60
 None
 0.89A 4a9jB-3rr1A:
undetectable		 4a9jB-3rr1A:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t6g SH2
DOMAIN-CONTAINING
PROTEIN 3C

(Homo sapiens) 		PF00617
(RasGEF) 		4 VAL A 589
LEU A 467
LEU A 479
ILE A 447
 None
 0.92A 4a9jB-3t6gA:
undetectable		 4a9jB-3t6gA:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tsn 4-HYDROXYTHREONINE-4
-PHOSPHATE
DEHYDROGENASE

(Campylobacter
jejuni) 		PF04166
(PdxA) 		4 VAL A  20
LEU A  52
LEU A  45
ILE A  36
 None
 0.86A 4a9jB-3tsnA:
undetectable		 4a9jB-3tsnA:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ttl POLYAMINE TRANSPORT
PROTEIN

(Pseudomonas
aeruginosa) 		PF13416
(SBP_bac_8) 		4 VAL A 128
LEU A  98
LEU A 103
ILE A  78
 None
 0.81A 4a9jB-3ttlA:
undetectable		 4a9jB-3ttlA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC

(Dictyostelium
discoideum) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		4 VAL A4688
LEU A4705
LEU A4654
ILE A4664
 None
 0.95A 4a9jB-3vkgA:
undetectable		 4a9jB-3vkgA:
3.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wpe TOLL-LIKE RECEPTOR 9

(Bos taurus) 		PF13516
(LRR_6)
PF13855
(LRR_8) 		4 VAL A 419
LEU A 397
LEU A 421
ILE A 409
 None
 0.93A 4a9jB-3wpeA:
undetectable		 4a9jB-3wpeA:
10.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zgk AVR3A11

(Phytophthora
capsici) 		PF16810
(RXLR) 		4 VAL A  75
LEU A 110
LEU A 106
ILE A  82
 None
 0.84A 4a9jB-3zgkA:
undetectable		 4a9jB-3zgkA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b6z FAMILY M14
UNASSIGNED PEPTIDASE

(Burkholderia
cenocepacia) 		PF00246
(Peptidase_M14) 		4 VAL A 212
LEU A 148
LEU A 137
ILE A 256
 None
 0.83A 4a9jB-4b6zA:
undetectable		 4a9jB-4b6zA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c90 ALPHA-GLUCURONIDASE
GH115

(Bacteroides
ovatus) 		PF15979
(Glyco_hydro_115) 		4 VAL A 463
LEU A 466
LEU A 204
ILE A 236
 None
 0.93A 4a9jB-4c90A:
3.1		 4a9jB-4c90A:
10.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ei8 PLASMID REPLICATION
PROTEIN REPX

(Bacillus cereus) 		PF00091
(Tubulin) 		4 VAL A 366
LEU A 150
LEU A 121
ILE A 180
 None
 0.95A 4a9jB-4ei8A:
undetectable		 4a9jB-4ei8A:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fbq DNA REPAIR AND
TELOMERE MAINTENANCE
PROTEIN NBS1,DNA
REPAIR PROTEIN RAD32
CHIMERIC PROTEIN

(Schizosaccharomyces
pombe) 		PF00149
(Metallophos)
PF04152
(Mre11_DNA_bind) 		4 VAL A1127
LEU A1084
LEU A1049
ILE A1066
 None
 0.86A 4a9jB-4fbqA:
undetectable		 4a9jB-4fbqA:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fcx DNA REPAIR PROTEIN
RAD32

(Schizosaccharomyces
pombe) 		no annotation 4 VAL B 127
LEU B  84
LEU B  49
ILE B  66
 None
 0.85A 4a9jB-4fcxB:
undetectable		 4a9jB-4fcxB:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fmz INTERNALIN

(Listeria
monocytogenes) 		PF12354
(Internalin_N)
PF12799
(LRR_4)
PF13855
(LRR_8) 		4 VAL A 294
LEU A 281
LEU A 303
ILE A 288
 None
 0.89A 4a9jB-4fmzA:
undetectable		 4a9jB-4fmzA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g9k ROTENONE-INSENSITIVE
NADH-UBIQUINONE
OXIDOREDUCTASE

(Saccharomyces
cerevisiae) 		PF07992
(Pyr_redox_2) 		4 VAL A 147
LEU A 157
LEU A 159
ILE A 167
 VAL  A 147 ( 0.6A)
LEU  A 157 ( 0.6A)
LEU  A 159 ( 0.6A)
ILE  A 167 ( 0.7A)
 0.81A 4a9jB-4g9kA:
undetectable		 4a9jB-4g9kA:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4glx DNA LIGASE

(Escherichia
coli) 		PF01653
(DNA_ligase_aden)
PF03119
(DNA_ligase_ZBD)
PF03120
(DNA_ligase_OB)
PF12826
(HHH_2)
PF14520
(HHH_5) 		4 VAL A 444
LEU A 474
LEU A 500
ILE A 458
 None
 0.75A 4a9jB-4glxA:
undetectable		 4a9jB-4glxA:
13.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hbx BROMODOMAIN-CONTAINI
NG PROTEIN 4

(Homo sapiens) 		PF00439
(Bromodomain) 		5 VAL A  87
LEU A  92
LEU A  94
ASN A 140
ILE A 146
 14X  A 201 (-4.7A)
14X  A 201 (-4.4A)
None
14X  A 201 (-3.1A)
14X  A 201 ( 4.0A)
 0.39A 4a9jB-4hbxA:
20.8		 4a9jB-4hbxA:
70.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hhr ALPHA-DIOXYGENASE

(Arabidopsis
thaliana) 		PF03098
(An_peroxidase) 		4 VAL A 477
LEU A 482
LEU A 479
ASN A 267
 None
HEM  A 701 (-4.5A)
HEM  A 701 (-4.5A)
HEM  A 701 ( 3.4A)
 0.85A 4a9jB-4hhrA:
2.8		 4a9jB-4hhrA:
12.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i0o PROTEIN ELYS

(Mus musculus) 		PF16687
(ELYS-bb) 		4 VAL A 197
LEU A 211
LEU A 152
ILE A 193
 None
 0.92A 4a9jB-4i0oA:
undetectable		 4a9jB-4i0oA:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i6j F-BOX/LRR-REPEAT
PROTEIN 3

(Homo sapiens) 		PF12937
(F-box-like) 		4 VAL B 380
LEU B 387
LEU B 416
ILE B 392
 None
 0.89A 4a9jB-4i6jB:
undetectable		 4a9jB-4i6jB:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ikg CELL DEATH ACTIVATOR
CIDE-3

(Mus musculus) 		PF02017
(CIDE-N) 		4 VAL A 109
LEU A  83
LEU A  67
ILE A  58
 None
 0.95A 4a9jB-4ikgA:
undetectable		 4a9jB-4ikgA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k0e HEAVY METAL CATION
TRICOMPONENT EFFLUX
PUMP ZNEA(CZCA-LIKE)

(Cupriavidus
metallidurans) 		PF00873
(ACR_tran) 		4 VAL A  50
LEU A  92
LEU A  90
ASN A 597
 None
 0.91A 4a9jB-4k0eA:
undetectable		 4a9jB-4k0eA:
9.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oqf PROTEIN RECA

(Mycobacterium
tuberculosis) 		PF00154
(RecA) 		4 VAL A  62
LEU A 216
LEU A 176
ILE A 144
 None
 0.87A 4a9jB-4oqfA:
undetectable		 4a9jB-4oqfA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tkm NADH-DEPENDENT
REDUCTASE FOR
4-DEOXY-L-ERYTHRO-5-
HEXOSEULOSE URONATE

(Sphingomonas
sp. A1) 		PF13561
(adh_short_C2) 		4 VAL A  76
LEU A  11
LEU A  89
ILE A  66
 None
 0.90A 4a9jB-4tkmA:
undetectable		 4a9jB-4tkmA:
17.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4uyd BROMODOMAIN-CONTAINI
NG PROTEIN 4

(Homo sapiens) 		PF00439
(Bromodomain) 		5 VAL A  87
LEU A  92
LEU A  94
ASN A 140
ILE A 146
 V1T  A1171 (-4.9A)
V1T  A1171 (-3.8A)
None
V1T  A1171 (-3.1A)
DMS  A1169 ( 4.3A)
 0.32A 4a9jB-4uydA:
20.8		 4a9jB-4uydA:
71.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4uyg BROMODOMAIN-CONTAINI
NG PROTEIN 2

(Homo sapiens) 		PF00439
(Bromodomain) 		4 VAL A 376
LEU A 381
LEU A 383
ASN A 429
 73B  A1456 (-4.0A)
73B  A1456 (-4.9A)
73B  A1456 (-4.9A)
73B  A1456 (-3.3A)
 0.36A 4a9jB-4uygA:
19.2		 4a9jB-4uygA:
48.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w8j PESTICIDAL CRYSTAL
PROTEIN CRY1AC

(Bacillus
thuringiensis) 		PF00555
(Endotoxin_M)
PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N) 		4 VAL A 160
LEU A 148
LEU A 157
ILE A  97
 None
 0.80A 4a9jB-4w8jA:
2.9		 4a9jB-4w8jA:
10.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wk0 INTEGRIN BETA-1

(Homo sapiens) 		PF00362
(Integrin_beta)
PF17205
(PSI_integrin) 		4 VAL B 436
LEU B 101
LEU B 438
ILE B 375
 None
 0.95A 4a9jB-4wk0B:
undetectable		 4a9jB-4wk0B:
15.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xzg HELICASE-LIKE
TRANSCRIPTION FACTOR

(Homo sapiens) 		PF08797
(HIRAN) 		4 VAL A 160
LEU A 164
LEU A 171
ILE A 130
 None
 0.93A 4a9jB-4xzgA:
undetectable		 4a9jB-4xzgA:
26.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4z93 BROMODOMAIN-CONTAINI
NG PROTEIN 4

(Homo sapiens) 		PF00439
(Bromodomain) 		4 VAL A 380
LEU A 385
LEU A 387
ASN A 433
 4LD  A 501 ( 3.8A)
4LD  A 501 (-4.1A)
4LD  A 501 (-4.4A)
4LD  A 501 (-2.8A)
 0.23A 4a9jB-4z93A:
19.2		 4a9jB-4z93A:
37.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zke SUPERKILLER PROTEIN
7

(Saccharomyces
cerevisiae) 		PF00009
(GTP_EFTU) 		4 VAL A 708
LEU A 687
LEU A 674
ILE A 659
 VAL  A 708 ( 0.6A)
LEU  A 687 ( 0.6A)
LEU  A 674 ( 0.6A)
ILE  A 659 ( 0.7A)
 0.74A 4a9jB-4zkeA:
undetectable		 4a9jB-4zkeA:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eny POLYKETIDE SYNTHASE
PKSL

(Bacillus
subtilis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		4 VAL A 193
LEU A 239
LEU A 241
ILE A 419
 None
 0.95A 4a9jB-5enyA:
undetectable		 4a9jB-5enyA:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f3y UNCONVENTIONAL
MYOSIN-VIIB

(Mus musculus) 		PF00784
(MyTH4) 		4 VAL A1433
LEU A1450
LEU A1436
ILE A1410
 None
 0.95A 4a9jB-5f3yA:
undetectable		 4a9jB-5f3yA:
14.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hjc BROMODOMAIN-CONTAINI
NG PROTEIN 3

(Homo sapiens) 		PF00439
(Bromodomain) 		4 VAL A 338
LEU A 343
LEU A 345
ASN A 391
 None
 0.37A 4a9jB-5hjcA:
19.3		 4a9jB-5hjcA:
37.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5huu ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
[UDP-FORMING]

(Candida
albicans) 		PF00982
(Glyco_transf_20) 		4 VAL A   9
LEU A 146
LEU A 149
ILE A  78
 None
 0.90A 4a9jB-5huuA:
undetectable		 4a9jB-5huuA:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iy9 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB1

(Homo sapiens) 		PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04990
(RNA_pol_Rpb1_7)
PF04992
(RNA_pol_Rpb1_6)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4) 		4 VAL A 545
LEU A 640
LEU A 645
ILE A 595
 None
 0.91A 4a9jB-5iy9A:
undetectable		 4a9jB-5iy9A:
5.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lc5 NADH DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR PROTEIN
2, MITOCHONDRIAL

(Bos taurus) 		PF00346
(Complex1_49kDa) 		4 VAL D 184
LEU D 207
LEU D 203
ILE D 144
 None
 0.77A 4a9jB-5lc5D:
undetectable		 4a9jB-5lc5D:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lgx PENTAERYTHRITOL
TETRANITRATE
REDUCTASE

(Enterobacter
cloacae) 		PF00724
(Oxidored_FMN) 		4 VAL A 217
LEU A 180
LEU A 188
ILE A  61
 None
 0.93A 4a9jB-5lgxA:
undetectable		 4a9jB-5lgxA:
21.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5n15 BROMODOMAIN-CONTAINI
NG FACTOR 1

(Candida
albicans) 		PF00439
(Bromodomain) 		4 VAL A 238
LEU A 243
ASN A 291
ILE A 297
 None
None
IOD  A 404 (-3.9A)
IOD  A 404 ( 4.8A)
 0.55A 4a9jB-5n15A:
17.1		 4a9jB-5n15A:
31.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n6v AMYLOSUCRASE

(Neisseria
polysaccharea) 		no annotation 4 VAL A 181
LEU A 132
LEU A 135
ILE A 169
 None
 0.94A 4a9jB-5n6vA:
undetectable		 4a9jB-5n6vA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nn8 LYSOSOMAL
ALPHA-GLUCOSIDASE

(Homo sapiens) 		no annotation 4 VAL A 939
LEU A 941
LEU A 901
ILE A 885
 CSO  A 938 ( 2.8A)
None
None
None
 0.82A 4a9jB-5nn8A:
undetectable		 4a9jB-5nn8A:
10.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nph HEAVY CHAIN OF FAB
FRAGMENT DERIVED
FROM
NON-NEUTRALIZING
ANTIBODY DAO5

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 VAL H 116
LEU H  18
LEU H  86
ILE H  81
 None
 0.91A 4a9jB-5nphH:
undetectable		 4a9jB-5nphH:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5npi SINGLE CHAIN
VARIABLE FRAGMENT OF
THE NON-NEUTRALIZING
ANTIBODY DAO5

(Mus musculus) 		PF07686
(V-set) 		4 VAL A 116
LEU A  18
LEU A  86
ILE A  81
 None
 0.85A 4a9jB-5npiA:
undetectable		 4a9jB-5npiA:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5opt RIBOSOMAL PROTEIN
S7, PUTATIVE

(Trypanosoma
cruzi) 		no annotation 4 VAL Q  76
LEU Q  83
LEU Q  98
ASN Q  49
 None
 0.71A 4a9jB-5optQ:
undetectable		 4a9jB-5optQ:
21.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5u6v BROMODOMAIN-CONTAINI
NG PROTEIN 2

(Homo sapiens) 		no annotation 4 VAL A 376
LEU A 381
LEU A 383
ASN A 429
 7WY  A 501 ( 4.5A)
7WY  A 501 (-4.9A)
None
7WY  A 501 (-3.4A)
 0.33A 4a9jB-5u6vA:
19.2		 4a9jB-5u6vA:
39.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u9n BROMO DOMAIN
CONTAINING PROTEIN

(Cryptosporidium
parvum) 		PF00439
(Bromodomain) 		4 VAL A 332
LEU A 338
ASN A 413
ILE A 422
 BMF  A 501 (-4.2A)
BMF  A 501 ( 4.9A)
BMF  A 501 (-2.8A)
BMF  A 501 ( 4.4A)
 0.81A 4a9jB-5u9nA:
15.7		 4a9jB-5u9nA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v6b PDZ
DOMAIN-CONTAINING
PROTEIN GIPC1

(Mus musculus) 		PF00595
(PDZ) 		4 VAL A 134
LEU A 209
LEU A 211
ILE A 166
 None
 0.88A 4a9jB-5v6bA:
undetectable		 4a9jB-5v6bA:
18.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5vbr BROMODOMAIN
TESTIS-SPECIFIC
PROTEIN

(Homo sapiens) 		no annotation 5 VAL A  56
LEU A  61
LEU A  63
ASN A 109
ILE A 115
 IBI  A 201 ( 4.6A)
IBI  A 201 (-4.2A)
IBI  A 201 (-4.9A)
IBI  A 201 (-3.3A)
IBI  A 201 ( 3.8A)
 0.68A 4a9jB-5vbrA:
20.3		 4a9jB-5vbrA:
55.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xog RNA POLYMERASE II
THIRD LARGEST
SUBUNIT B44, PART OF
CENTRAL CORE

(Komagataella
phaffii) 		PF01000
(RNA_pol_A_bac)
PF01193
(RNA_pol_L) 		4 VAL C   7
LEU C  21
LEU C  19
ILE C 248
 None
 0.87A 4a9jB-5xogC:
undetectable		 4a9jB-5xogC:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zln TOLL-LIKE RECEPTOR 9

(Mus musculus) 		no annotation 4 VAL A 420
LEU A 398
LEU A 422
ILE A 410
 None
 0.90A 4a9jB-5zlnA:
undetectable		 4a9jB-5zlnA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cw0 CGD2_2690 PROTEIN

(Cryptosporidium
parvum) 		no annotation 4 VAL A  30
LEU A  35
LEU A  37
ASN A  83
 R78  A 201 (-4.5A)
R78  A 201 (-4.9A)
None
R78  A 201 (-3.3A)
 0.66A 4a9jB-6cw0A:
17.8		 4a9jB-6cw0A:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dne BROMODOMAIN-CONTAINI
NG PROTEIN 4

(Homo sapiens) 		no annotation 5 VAL A  87
LEU A  92
LEU A  94
ASN A 140
ILE A 146
 H1V  A 501 ( 4.4A)
H1V  A 501 (-4.2A)
H1V  A 501 (-4.7A)
H1V  A 501 (-3.2A)
H1V  A 501 (-3.8A)
 0.45A 4a9jB-6dneA:
20.5		 4a9jB-6dneA:
undetectable