SIMILAR PATTERNS OF AMINO ACIDS FOR 4A99_C_MIYC392

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1chd CHEB METHYLESTERASE

(Salmonella
enterica) 		PF01339
(CheB_methylest) 		5 PRO A 229
GLU A 213
VAL A 220
ILE A 245
TYR A 226
 None
 1.38A 4a99A-1chdA:
undetectable
4a99C-1chdA:
undetectable		 4a99A-1chdA:
20.19
4a99C-1chdA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cj2 PROTEIN
(P-HYDROXYBENZOATE
HYDROXYLASE)

(Pseudomonas
fluorescens) 		PF01494
(FAD_binding_3) 		5 GLU A 383
PHE A 342
VAL A  75
ILE A  86
GLU A  49
 None
 1.17A 4a99A-1cj2A:
29.1
4a99C-1cj2A:
29.0		 4a99A-1cj2A:
23.11
4a99C-1cj2A:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hkx CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN

(Mus musculus) 		PF08332
(CaMKII_AD) 		5 TYR A 369
GLU A 355
ILE A 350
ILE A 414
GLU A 451
 None
 1.43A 4a99A-1hkxA:
undetectable
4a99C-1hkxA:
undetectable		 4a99A-1hkxA:
16.32
4a99C-1hkxA:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jsx GLUCOSE-INHIBITED
DIVISION PROTEIN B

(Escherichia
coli) 		PF02527
(GidB) 		5 PRO A 131
GLU A 130
ARG A  68
VAL A 120
GLU A 125
 None
 1.33A 4a99A-1jsxA:
2.8
4a99C-1jsxA:
2.7		 4a99A-1jsxA:
21.37
4a99C-1jsxA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nug PROTEIN-GLUTAMINE
GLUTAMYLTRANSFERASE
E

(Homo sapiens) 		PF00868
(Transglut_N)
PF00927
(Transglut_C)
PF01841
(Transglut_core) 		5 PHE A 452
VAL A 413
ILE A 397
ILE A 418
GLU A 443
 None
None
None
None
CA  A 704 (-2.5A)
 1.45A 4a99A-1nugA:
undetectable
4a99C-1nugA:
undetectable		 4a99A-1nugA:
21.66
4a99C-1nugA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tww DHPS,
DIHYDROPTEROATE
SYNTHASE

(Bacillus
anthracis) 		PF00809
(Pterin_bind) 		5 GLU A 113
VAL A  83
ILE A  80
GLN A 110
ILE A 112
 None
 1.30A 4a99A-1twwA:
undetectable
4a99C-1twwA:
undetectable		 4a99A-1twwA:
24.82
4a99C-1twwA:
24.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uok OLIGO-1,6-GLUCOSIDAS
E

(Bacillus cereus) 		PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C) 		5 PRO A 331
ARG A 336
PHE A 337
GLN A 330
TYR A 324
 None
 1.34A 4a99A-1uokA:
undetectable
4a99C-1uokA:
undetectable		 4a99A-1uokA:
21.53
4a99C-1uokA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dr1 386AA LONG
HYPOTHETICAL SERINE
AMINOTRANSFERASE

(Pyrococcus
horikoshii) 		PF00266
(Aminotran_5) 		5 PRO A 164
GLU A 167
VAL A 150
ILE A 152
GLU A 174
 None
 1.25A 4a99A-2dr1A:
2.3
4a99C-2dr1A:
2.3		 4a99A-2dr1A:
21.56
4a99C-2dr1A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f8t ARGONAUTE PROTEIN

(Aquifex
aeolicus) 		PF02171
(Piwi) 		5 GLU A 445
VAL A 359
ILE A 357
ILE A 408
GLU A 405
 None
 1.25A 4a99A-2f8tA:
undetectable
4a99C-2f8tA:
undetectable		 4a99A-2f8tA:
20.76
4a99C-2f8tA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h5n HYPOTHETICAL PROTEIN
PG_1108

(Porphyromonas
gingivalis) 		PF05099
(TerB) 		5 GLU A  39
VAL A 123
ILE A 101
ILE A  94
GLU A  46
 None
 1.35A 4a99A-2h5nA:
undetectable
4a99C-2h5nA:
undetectable		 4a99A-2h5nA:
14.54
4a99C-2h5nA:
14.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2obe HEXON

(Human
mastadenovirus
E) 		PF01065
(Adeno_hexon)
PF03678
(Adeno_hexon_C) 		5 GLU A 185
VAL A 266
ILE A 165
TYR A 268
GLU A 270
 None
 1.22A 4a99A-2obeA:
undetectable
4a99C-2obeA:
undetectable		 4a99A-2obeA:
17.49
4a99C-2obeA:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r26 CITRATE SYNTHASE

(Thermoplasma
acidophilum) 		PF00285
(Citrate_synt) 		5 TYR A 324
VAL A 345
ILE A 128
GLN A  51
ILE A  50
 None
 1.45A 4a99A-2r26A:
undetectable
4a99C-2r26A:
undetectable		 4a99A-2r26A:
22.59
4a99C-2r26A:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ux0 CALCIUM-CALMODULIN
DEPENDENT PROTEIN
KINASE (CAM KINASE)
II GAMMA

(Homo sapiens) 		PF08332
(CaMKII_AD) 		5 TYR A 418
GLU A 404
ILE A 399
ILE A 463
GLU A 500
 None
 1.49A 4a99A-2ux0A:
undetectable
4a99C-2ux0A:
undetectable		 4a99A-2ux0A:
19.02
4a99C-2ux0A:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z0t PUTATIVE
UNCHARACTERIZED
PROTEIN PH0355

(Pyrococcus
horikoshii) 		PF04266
(ASCH) 		5 GLU A  67
VAL A  76
ILE A  69
ILE A  22
GLU A  23
 None
 1.33A 4a99A-2z0tA:
undetectable
4a99C-2z0tA:
undetectable		 4a99A-2z0tA:
15.44
4a99C-2z0tA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3auf GLYCINAMIDE
RIBONUCLEOTIDE
TRANSFORMYLASE 1

(Symbiobacterium
toebii) 		PF00551
(Formyl_trans_N) 		5 VAL A 197
ILE A 149
GLN A 152
ILE A 177
GLU A 180
 None
 1.29A 4a99A-3aufA:
4.7
4a99C-3aufA:
4.3		 4a99A-3aufA:
24.94
4a99C-3aufA:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ewe NUCLEOPORIN NUP85

(Saccharomyces
cerevisiae) 		PF07575
(Nucleopor_Nup85) 		5 PRO B 407
GLU B 410
VAL B 181
ILE B 405
GLU B 174
 None
 1.35A 4a99A-3eweB:
undetectable
4a99C-3eweB:
undetectable		 4a99A-3eweB:
21.65
4a99C-3eweB:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h3l PUTATIVE SUGAR
HYDROLASE

(Parabacteroides
distasonis) 		PF06439
(DUF1080) 		5 GLU A 207
PHE A 210
VAL A 167
ILE A 171
ILE A 197
 None
 1.22A 4a99A-3h3lA:
undetectable
4a99C-3h3lA:
undetectable		 4a99A-3h3lA:
21.70
4a99C-3h3lA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3koy D-ORNITHINE
AMINOMUTASE E
COMPONENT

(Acetoanaerobium
sticklandii) 		PF02310
(B12-binding)
PF09043
(Lys-AminoMut_A)
PF16554
(OAM_dimer) 		5 TYR A 416
PHE A 391
VAL A 405
GLN A 186
TYR A 401
 None
 1.43A 4a99A-3koyA:
undetectable
4a99C-3koyA:
undetectable		 4a99A-3koyA:
19.53
4a99C-3koyA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ld2 PUTATIVE
ACETYLTRANSFERASE

(Streptococcus
mutans) 		PF00583
(Acetyltransf_1) 		5 GLU A  12
VAL A  61
ILE A  58
GLN A  13
ILE A  11
 None
 1.46A 4a99A-3ld2A:
undetectable
4a99C-3ld2A:
undetectable		 4a99A-3ld2A:
24.67
4a99C-3ld2A:
24.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mcu DIPICOLINATE
SYNTHASE, B CHAIN

(Bacillus cereus) 		PF02441
(Flavoprotein) 		5 PRO A  78
GLU A  77
VAL A  39
ILE A  70
ILE A  73
 None
 0.95A 4a99A-3mcuA:
5.1
4a99C-3mcuA:
4.7		 4a99A-3mcuA:
19.70
4a99C-3mcuA:
19.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3p9u TETX2 PROTEIN

(Bacteroides
thetaiotaomicron) 		PF01494
(FAD_binding_3) 		5 LYS A  64
TYR A  81
PRO A 106
GLU A 107
PHE A 110
 None
 0.63A 4a99A-3p9uA:
58.1
4a99C-3p9uA:
58.1		 4a99A-3p9uA:
94.47
4a99C-3p9uA:
94.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3p9u TETX2 PROTEIN

(Bacteroides
thetaiotaomicron) 		PF01494
(FAD_binding_3) 		6 VAL A 329
ILE A 333
GLN A 356
ILE A 359
TYR A 360
GLU A 363
 None
 0.33A 4a99A-3p9uA:
58.1
4a99C-3p9uA:
58.1		 4a99A-3p9uA:
94.47
4a99C-3p9uA:
94.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pdm COAT PROTEIN

(Hibiscus latent
Singapore virus) 		PF00721
(TMV_coat) 		5 GLU P  46
VAL P  22
ILE P  26
GLN P  47
ILE P  49
 None
 1.24A 4a99A-3pdmP:
undetectable
4a99C-3pdmP:
undetectable		 4a99A-3pdmP:
17.85
4a99C-3pdmP:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sgh SUSD HOMOLOG

(Bacteroides
thetaiotaomicron) 		PF12741
(SusD-like) 		5 TYR A 441
PRO A 287
ARG A 288
ILE A 417
TYR A 284
 None
 1.35A 4a99A-3sghA:
undetectable
4a99C-3sghA:
undetectable		 4a99A-3sghA:
21.34
4a99C-3sghA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t05 PYRUVATE KINASE

(Staphylococcus
aureus) 		PF00224
(PK)
PF00391
(PEP-utilizers)
PF02887
(PK_C) 		5 GLU A 141
VAL A 117
ILE A 135
ILE A  91
GLU A  89
 None
 1.45A 4a99A-3t05A:
undetectable
4a99C-3t05A:
undetectable		 4a99A-3t05A:
23.76
4a99C-3t05A:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vdg PROBABLE GLUCARATE
DEHYDRATASE

(Mycolicibacterium
smegmatis) 		PF13378
(MR_MLE_C) 		5 TYR A 395
VAL A 358
ILE A 383
GLN A  40
ILE A  39
 None
 0.86A 4a99A-3vdgA:
undetectable
4a99C-3vdgA:
undetectable		 4a99A-3vdgA:
23.55
4a99C-3vdgA:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a3q ALANINE RACEMASE 1

(Staphylococcus
aureus) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		5 GLU A 152
VAL A 165
ILE A 130
TYR A 147
GLU A 192
 None
 1.49A 4a99A-4a3qA:
undetectable
4a99C-4a3qA:
undetectable		 4a99A-4a3qA:
24.16
4a99C-4a3qA:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d10 COP9 SIGNALOSOME
COMPLEX SUBUNIT 6

(Homo sapiens) 		PF01398
(JAB)
PF13012
(MitMem_reg) 		5 GLU F 120
VAL F  39
ILE F  81
ILE F 146
GLU F 147
 None
 1.29A 4a99A-4d10F:
undetectable
4a99C-4d10F:
undetectable		 4a99A-4d10F:
19.53
4a99C-4d10F:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fo0 ACTIN-RELATED
PROTEIN 8

(Homo sapiens) 		PF00022
(Actin) 		5 TYR A 230
PRO A  68
ILE A  71
TYR A 219
GLU A 221
 None
 1.44A 4a99A-4fo0A:
undetectable
4a99C-4fo0A:
undetectable		 4a99A-4fo0A:
20.03
4a99C-4fo0A:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ft2 DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Zea mays) 		PF00145
(DNA_methylase)
PF00385
(Chromo)
PF01426
(BAH) 		5 PRO A 841
GLU A 844
ILE A 842
ILE A 847
TYR A 846
 None
 1.37A 4a99A-4ft2A:
3.8
4a99C-4ft2A:
3.2		 4a99A-4ft2A:
18.83
4a99C-4ft2A:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ft2 DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Zea mays) 		PF00145
(DNA_methylase)
PF00385
(Chromo)
PF01426
(BAH) 		5 TYR A 836
GLU A 844
ILE A 842
ILE A 847
TYR A 846
 None
 1.34A 4a99A-4ft2A:
3.8
4a99C-4ft2A:
3.2		 4a99A-4ft2A:
18.83
4a99C-4ft2A:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fye SIDF, INHIBITOR OF
GROWTH FAMILY,
MEMBER 3

(Legionella
pneumophila) 		no annotation 5 GLU A 299
VAL A 407
ILE A 393
GLN A 302
GLU A 355
 None
 1.22A 4a99A-4fyeA:
0.4
4a99C-4fyeA:
undetectable		 4a99A-4fyeA:
19.35
4a99C-4fyeA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ggp TRANS-2-ENOYL-COA
REDUCTASE

(Treponema
denticola) 		PF07055
(Eno-Rase_FAD_bd)
PF12241
(Enoyl_reductase)
PF12242
(Eno-Rase_NADH_b) 		5 TYR A 109
GLU A 128
VAL A  77
ILE A 122
ILE A 127
 None
 1.44A 4a99A-4ggpA:
3.8
4a99C-4ggpA:
3.8		 4a99A-4ggpA:
21.76
4a99C-4ggpA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ha7 2,5-DIAMINO-6-RIBOSY
LAMINO-4(3H)-PYRIMID
INONE 5'-PHOSPHATE
REDUCTASE

(Saccharomyces
cerevisiae) 		PF01872
(RibD_C) 		5 GLU A 171
VAL A 177
ILE A 103
ILE A 167
GLU A 166
 None
 1.40A 4a99A-4ha7A:
undetectable
4a99C-4ha7A:
undetectable		 4a99A-4ha7A:
20.35
4a99C-4ha7A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o79 PROBABLE
TRANSMEMBRANE
ASCORBATE
FERRIREDUCTASE 2

(Arabidopsis
thaliana) 		PF03188
(Cytochrom_B561) 		5 TYR A  70
VAL A 213
ILE A 214
ILE A 164
TYR A 165
 HEM  A 302 (-3.2A)
None
None
HEM  A 302 ( 4.9A)
None
 1.09A 4a99A-4o79A:
undetectable
4a99C-4o79A:
undetectable		 4a99A-4o79A:
21.61
4a99C-4o79A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wgx MOLINATE HYDROLASE

(Gulosibacter
molinativorax) 		PF01979
(Amidohydro_1) 		5 GLU A 118
PHE A 177
VAL A  94
ILE A  95
GLU A  88
 None
 1.49A 4a99A-4wgxA:
undetectable
4a99C-4wgxA:
undetectable		 4a99A-4wgxA:
22.01
4a99C-4wgxA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wzb NITROGENASE
MOLYBDENUM-IRON
PROTEIN ALPHA CHAIN

(Azotobacter
vinelandii) 		PF00148
(Oxidored_nitro) 		5 PHE A 431
VAL A 404
ILE A  59
ILE A 355
TYR A 354
 None
None
None
ICS  A1496 (-4.1A)
None
 1.13A 4a99A-4wzbA:
undetectable
4a99C-4wzbA:
undetectable		 4a99A-4wzbA:
20.32
4a99C-4wzbA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5evj ARSENITE
METHYLTRANSFERASE

(Chlamydomonas
reinhardtii) 		PF13847
(Methyltransf_31) 		5 GLU A 159
PHE A 163
VAL A 114
ILE A 146
GLU A 184
 None
 1.49A 4a99A-5evjA:
3.3
4a99C-5evjA:
3.3		 4a99A-5evjA:
22.37
4a99C-5evjA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f7u CYCLOALTERNAN-FORMIN
G ENZYME

(Listeria
monocytogenes) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2)
PF16338
(DUF4968)
PF16990
(CBM_35) 		5 TYR A 755
PRO A 806
GLU A 795
VAL A 789
ILE A 811
 None
 1.21A 4a99A-5f7uA:
undetectable
4a99C-5f7uA:
undetectable		 4a99A-5f7uA:
17.51
4a99C-5f7uA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fz5 TATA-BOX-BINDING
PROTEIN

(Saccharomyces
cerevisiae) 		PF00352
(TBP) 		5 TYR O 195
GLU O 228
VAL O 166
ILE O  63
TYR O 231
 None
 1.08A 4a99A-5fz5O:
undetectable
4a99C-5fz5O:
undetectable		 4a99A-5fz5O:
23.33
4a99C-5fz5O:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g5a GLUTATHIONE
S-TRANSFERASE U25

(Arabidopsis
thaliana) 		PF02798
(GST_N)
PF13410
(GST_C_2) 		5 TYR A 161
PHE A 164
VAL A 106
ILE A 131
ILE A 113
 None
 1.44A 4a99A-5g5aA:
undetectable
4a99C-5g5aA:
undetectable		 4a99A-5g5aA:
19.59
4a99C-5g5aA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ikp GLYCOGEN
PHOSPHORYLASE, BRAIN
FORM

(Homo sapiens) 		PF00343
(Phosphorylase) 		5 GLU A 348
VAL A 333
ILE A 335
ILE A 352
GLU A 357
 None
 1.43A 4a99A-5ikpA:
undetectable
4a99C-5ikpA:
undetectable		 4a99A-5ikpA:
19.41
4a99C-5ikpA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kwa PROTEASOME-ASSOCIATE
D ATPASE

(Mycobacterium
tuberculosis) 		PF00004
(AAA)
PF16450
(Prot_ATP_ID_OB) 		5 GLU A 262
VAL A 289
ILE A 435
GLN A 263
GLU A 269
 None
 1.41A 4a99A-5kwaA:
undetectable
4a99C-5kwaA:
undetectable		 4a99A-5kwaA:
22.05
4a99C-5kwaA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5na4 NADH
DEHYDROGENASE-LIKE
PROTEIN
SAOUHSC_00878

(Staphylococcus
aureus) 		no annotation 5 GLU A  94
VAL A  79
ILE A  38
ILE A  99
TYR A 100
 None
 1.33A 4a99A-5na4A:
11.5
4a99C-5na4A:
11.5		 4a99A-5na4A:
13.51
4a99C-5na4A:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o6b ATP-DEPENDENT DNA
HELICASE PIF1

(Saccharomyces
cerevisiae) 		no annotation 5 GLU A 249
VAL A 339
ILE A 374
ILE A 245
GLU A 270
 None
 1.26A 4a99A-5o6bA:
undetectable
4a99C-5o6bA:
undetectable		 4a99A-5o6bA:
16.13
4a99C-5o6bA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5veh KYNURENINE
AMINOTRANSFERASE

(Aedes aegypti) 		no annotation 5 PRO A 140
GLU A 139
VAL A 122
ILE A 118
ILE A 130
 None
 1.49A 4a99A-5vehA:
undetectable
4a99C-5vehA:
undetectable		 4a99A-5vehA:
22.22
4a99C-5vehA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xya -

(-) 		no annotation 5 PRO A 597
VAL A 283
ILE A 286
GLN A 622
ILE A 623
 None
 0.85A 4a99A-5xyaA:
undetectable
4a99C-5xyaA:
undetectable		 4a99A-5xyaA:
undetectable
4a99C-5xyaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bzg PROTEIN ZIP2
SPORULATION-SPECIFIC
PROTEIN 16

(Saccharomyces
cerevisiae) 		no annotation 5 TYR B 604
GLU A 130
PHE A 135
VAL A  23
ILE A  14
 None
 1.42A 4a99A-6bzgB:
undetectable
4a99C-6bzgB:
undetectable		 4a99A-6bzgB:
11.20
4a99C-6bzgB:
11.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6exv DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB2

(Sus scrofa) 		no annotation 5 ARG B1050
PHE B 935
VAL B 801
ILE B 928
ILE B 931
 None
 1.49A 4a99A-6exvB:
0.0
4a99C-6exvB:
1.7		 4a99A-6exvB:
13.10
4a99C-6exvB:
13.10