SIMILAR PATTERNS OF AMINO ACIDS FOR 4A99_A_MIYA392

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n26 AMINO ACID ABC
TRANSPORTER,
PERIPLASMIC AMINO
ACID-BINDING PROTEIN

(Chlamydia
pneumoniae) 		PF00497
(SBP_bac_3) 		5 LEU A 253
TYR A 114
SER A  99
GLN A 150
VAL A 213
 None
None
ARG  A 500 (-2.9A)
ARG  A 500 ( 4.0A)
None
 1.36A 4a99A-3n26A:
0.6
4a99C-3n26A:
0.6		 4a99A-3n26A:
20.70
4a99C-3n26A:
20.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3p9u TETX2 PROTEIN

(Bacteroides
thetaiotaomicron) 		PF01494
(FAD_binding_3) 		5 LYS A  72
LEU A  77
GLN A  78
TYR A  81
PHE A 110
 None
 0.55A 4a99A-3p9uA:
58.1
4a99C-3p9uA:
58.1		 4a99A-3p9uA:
94.47
4a99C-3p9uA:
94.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qax PROBABLE ABC
TRANSPORTER
ARGININE-BINDING
PROTEIN ARTJ

(Chlamydia
pneumoniae) 		PF00497
(SBP_bac_3) 		5 LEU A 232
TYR A  93
SER A  78
GLN A 129
VAL A 192
 None
None
ARG  A 600 (-2.6A)
ARG  A 600 ( 4.0A)
None
 1.41A 4a99A-3qaxA:
0.0
4a99C-3qaxA:
0.0		 4a99A-3qaxA:
21.20
4a99C-3qaxA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4byf UNCONVENTIONAL
MYOSIN-IC

(Homo sapiens) 		PF00063
(Myosin_head)
PF00612
(IQ) 		5 LEU A 382
TYR A 122
PHE A 121
SER A  73
VAL A  72
 None
 1.49A 4a99A-4byfA:
0.0
4a99C-4byfA:
0.0		 4a99A-4byfA:
20.82
4a99C-4byfA:
20.82