SIMILAR PATTERNS OF AMINO ACIDS FOR 4A97_J_ZPCJ1318_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gbg (1,3-1,4)-BETA-D-GLU
CAN 4
GLUCANOHYDROLASE

(Bacillus
licheniformis) 		PF00722
(Glyco_hydro_16) 		4 GLU A  46
PHE A  10
TYR A 144
HIS A 145
 None
 1.06A 4a97J-1gbgA:
0.0		 4a97J-1gbgA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gxl CHROMOSOME
SEGREGATION SMC
PROTEIN

(Thermotoga
maritima) 		PF06470
(SMC_hinge) 		4 GLU A 587
GLU A 589
PHE A 592
TYR A 633
 None
 1.36A 4a97J-1gxlA:
0.0		 4a97J-1gxlA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l9x GAMMA-GLUTAMYL
HYDROLASE

(Homo sapiens) 		PF07722
(Peptidase_C26) 		4 GLU A 227
GLU A 222
PHE A 287
HIS A 171
 None
 1.44A 4a97J-1l9xA:
0.0		 4a97J-1l9xA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wdt ELONGATION FACTOR G
HOMOLOG

(Thermus
thermophilus) 		PF00009
(GTP_EFTU)
PF00679
(EFG_C)
PF03764
(EFG_IV)
PF14492
(EFG_II) 		4 GLU A 419
PHE A 528
TYR A 646
HIS A 645
 None
 1.32A 4a97J-1wdtA:
0.0		 4a97J-1wdtA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zbt PEPTIDE CHAIN
RELEASE FACTOR 1

(Streptococcus
mutans) 		PF00472
(RF-1)
PF03462
(PCRF) 		4 GLU A 152
GLU A 257
TYR A 228
HIS A 229
 None
 1.40A 4a97J-1zbtA:
0.0		 4a97J-1zbtA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j4x MITOGEN

(Streptococcus
dysgalactiae) 		PF02876
(Stap_Strp_tox_C) 		4 GLU A 191
PHE A 136
TYR A 171
HIS A 170
 None
None
None
ZN  A1211 (-3.1A)
 1.22A 4a97J-2j4xA:
0.0		 4a97J-2j4xA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2n2h PAIRED AMPHIPATHIC
HELIX PROTEIN SIN3A
SIN3 HISTONE
DEACETYLASE
COREPRESSOR COMPLEX
COMPONENT SDS3

(Mus musculus) 		PF08295
(Sin3_corepress)
no annotation 		4 GLU B 616
GLU B 619
PHE B 714
TYR A 209
 None
 1.37A 4a97J-2n2hB:
undetectable		 4a97J-2n2hB:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qml BH2621 PROTEIN

(Bacillus
halodurans) 		PF13523
(Acetyltransf_8) 		4 GLU A  85
PHE A  63
TYR A  56
HIS A  39
 None
 1.41A 4a97J-2qmlA:
undetectable		 4a97J-2qmlA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vmf BETA-MANNOSIDASE

(Bacteroides
thetaiotaomicron) 		PF00703
(Glyco_hydro_2) 		4 GLU A  90
PHE A 156
TYR A 153
HIS A 151
 EDO  A1875 (-3.3A)
None
None
None
 1.02A 4a97J-2vmfA:
undetectable		 4a97J-2vmfA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vzn VENOM ALLERGEN 3

(Solenopsis
invicta) 		PF00188
(CAP) 		4 GLU A  62
PHE A 142
TYR A 136
HIS A  50
 None
 1.43A 4a97J-2vznA:
undetectable		 4a97J-2vznA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w8s PHOSPHONATE
MONOESTER HYDROLASE

(Paraburkholderia
caryophylli) 		PF00884
(Sulfatase)
PF16347
(DUF4976) 		4 GLU A 466
GLU A 441
PHE A 458
TYR A 412
 None
 1.23A 4a97J-2w8sA:
undetectable		 4a97J-2w8sA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xze CHARGED
MULTIVESICULAR BODY
PROTEIN 3
STAM-BINDING PROTEIN

(Homo sapiens) 		PF08969
(USP8_dimer)
no annotation 		4 GLU Q 206
GLU Q 207
TYR A  80
HIS A  77
 None
 1.30A 4a97J-2xzeQ:
undetectable		 4a97J-2xzeQ:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y6i COLLAGENASE

(Hathewaya
histolytica) 		PF01752
(Peptidase_M9)
PF08453
(Peptidase_M9_N) 		4 GLU A 691
GLU A 695
TYR A 758
HIS A 684
 None
 1.49A 4a97J-2y6iA:
undetectable		 4a97J-2y6iA:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bq9 PREDICTED ROSSMANN
FOLD
NUCLEOTIDE-BINDING
DOMAIN-CONTAINING
PROTEIN

(Idiomarina
baltica) 		PF03641
(Lysine_decarbox)
PF11892
(DUF3412)
PF14793
(DUF4478) 		4 GLU A  81
GLU A  82
PHE A  84
TYR A  58
 None
 1.10A 4a97J-3bq9A:
undetectable		 4a97J-3bq9A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d6e BETA-GLUCANASE

(Bacillus
licheniformis) 		PF00722
(Glyco_hydro_16) 		4 GLU A  33
PHE A  10
TYR A 131
HIS A 132
 None
 0.99A 4a97J-3d6eA:
undetectable		 4a97J-3d6eA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m8n POSSIBLE GLUTATHIONE
S-TRANSFERASE

(Rhodopseudomonas
palustris) 		PF00043
(GST_C)
PF02798
(GST_N) 		4 GLU A 103
PHE A 111
TYR A 166
HIS A 168
 None
 1.45A 4a97J-3m8nA:
undetectable		 4a97J-3m8nA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mx3 SUSD HOMOLOG

(Bacteroides
fragilis) 		PF12771
(SusD-like_2) 		4 GLU A  62
PHE A 432
TYR A 249
HIS A 252
 MG  A 601 (-2.5A)
None
None
None
 1.42A 4a97J-3mx3A:
undetectable		 4a97J-3mx3A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o5s BETA-GLUCANASE

(Bacillus
subtilis) 		PF00722
(Glyco_hydro_16) 		4 GLU A  74
PHE A  38
TYR A 172
HIS A 173
 None
 0.97A 4a97J-3o5sA:
undetectable		 4a97J-3o5sA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s51 FANCONI ANEMIA GROUP
I PROTEIN HOMOLOG

(Mus musculus) 		PF14674
(FANCI_S1-cap)
PF14675
(FANCI_S1)
PF14676
(FANCI_S2)
PF14677
(FANCI_S3)
PF14678
(FANCI_S4)
PF14679
(FANCI_HD1)
PF14680
(FANCI_HD2) 		4 GLU A 750
PHE A 808
TYR A 840
HIS A 839
 None
 1.46A 4a97J-3s51A:
3.0		 4a97J-3s51A:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a2n ISOPRENYLCYSTEINE
CARBOXYL
METHYLTRANSFERASE

(Methanosarcina
acetivorans) 		PF04140
(ICMT) 		4 GLU B  42
GLU B 167
TYR B 129
HIS B 131
 None
SAH  B1193 (-3.5A)
SAH  B1193 (-3.4A)
None
 1.16A 4a97J-4a2nB:
undetectable		 4a97J-4a2nB:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f9l 20.1 ANTI-BTN3A1
ANTIBODY FRAGMENT

(Mus musculus) 		no annotation 4 GLU D 230
GLU D 181
TYR D  94
HIS D  92
 None
 1.49A 4a97J-4f9lD:
undetectable		 4a97J-4f9lD:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fk8 FERREDOXIN--NADP
REDUCTASE

(Burkholderia
thailandensis) 		PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6) 		4 GLU A  80
PHE A  82
TYR A 170
HIS A 173
 None
 1.47A 4a97J-4fk8A:
undetectable		 4a97J-4fk8A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tqo METHANOL
DEHYDROGENASE
PROTEIN, LARGE
SUBUNIT
METHANOL
DEHYDROGENASE, SMALL
SUBUNIT

(Methylococcus
capsulatus) 		PF02315
(MDH)
no annotation 		4 GLU B 171
GLU B 170
PHE I  86
HIS B 147
 None
 1.46A 4a97J-4tqoB:
undetectable		 4a97J-4tqoB:
19.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4twf CYS-LOOP
LIGAND-GATED ION
CHANNEL

(Dickeya
chrysanthemi) 		PF02931
(Neur_chan_LBD) 		4 GLU A  77
GLU A 131
PHE A 133
TYR A 175
 BR7  A 401 ( 4.9A)
BR7  A 401 (-4.1A)
BR7  A 401 (-4.5A)
BR7  A 401 (-3.9A)
 0.57A 4a97J-4twfA:
33.7		 4a97J-4twfA:
99.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4yeu CYS-LOOP
LIGAND-GATED ION
CHANNEL,PROTON-GATED
ION CHANNEL

(Dickeya
chrysanthemi;
Gloeobacter
violaceus) 		PF02931
(Neur_chan_LBD) 		5 GLU A  77
GLU A 131
PHE A 133
TYR A 175
HIS A 177
 None
 0.88A 4a97J-4yeuA:
29.6		 4a97J-4yeuA:
71.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z81 EGF FAMILY
DOMAIN-CONTAINING
PROTEIN

(Toxoplasma
gondii) 		PF02430
(AMA-1)
PF07974
(EGF_2) 		4 GLU A 195
GLU A 201
TYR A 346
HIS A 347
 None
 1.24A 4a97J-4z81A:
undetectable		 4a97J-4z81A:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zkq PUTATIVE
UNCHARACTERIZED
PROTEIN

(Cricetid
gammaherpesvirus
2) 		no annotation 4 GLU A 116
GLU A 115
PHE A 110
HIS A 253
 None
 1.08A 4a97J-4zkqA:
undetectable		 4a97J-4zkqA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c3m PUTATIVE
6-PHOSPHO-BETA-GLUCO
SIDASE

(Geobacillus
stearothermophilus) 		PF02056
(Glyco_hydro_4)
PF11975
(Glyco_hydro_4C) 		4 GLU A 270
GLU A 271
TYR A 260
HIS A 202
 None
None
None
MN  A 501 (-3.4A)
 1.33A 4a97J-5c3mA:
undetectable		 4a97J-5c3mA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c3m PUTATIVE
6-PHOSPHO-BETA-GLUCO
SIDASE

(Geobacillus
stearothermophilus) 		PF02056
(Glyco_hydro_4)
PF11975
(Glyco_hydro_4C) 		4 GLU A 270
GLU A 271
TYR A 260
HIS A 258
 None
 1.29A 4a97J-5c3mA:
undetectable		 4a97J-5c3mA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eio N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE/N-ACET
YL-GAMMA-AMINOADIPYL
-PHOSPHATE REDUCTASE

(Thermus
thermophilus) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		4 GLU A 250
GLU A 296
PHE A 295
TYR A 279
 None
 1.43A 4a97J-5eioA:
undetectable		 4a97J-5eioA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hpk E3 UBIQUITIN-PROTEIN
LIGASE NEDD4-LIKE
UBIQUITIN VARIANT
NL.1

(Homo sapiens) 		PF00240
(ubiquitin)
PF00632
(HECT) 		4 GLU B  77
GLU A 609
TYR A 689
HIS A 686
 None
 1.43A 4a97J-5hpkB:
undetectable		 4a97J-5hpkB:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k2m PROBABLE LYSINE
BIOSYNTHESIS PROTEIN
RIMK-RELATED LYSINE
BIOSYNTHESIS PROTEIN

(Thermococcus
kodakarensis) 		PF08443
(RimK)
no annotation 		4 GLU E  49
PHE A  54
TYR A 156
HIS A 159
 None
 1.29A 4a97J-5k2mE:
undetectable		 4a97J-5k2mE:
9.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kzm TRYPTOPHAN SYNTHASE
ALPHA CHAIN
TRYPTOPHAN SYNTHASE
BETA CHAIN

(Francisella
tularensis) 		PF00290
(Trp_syntA)
PF00291
(PALP) 		4 GLU A 139
GLU A 136
TYR B   7
HIS B 314
 None
 1.39A 4a97J-5kzmA:
undetectable		 4a97J-5kzmA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mqs BETA-L-ARABINOBIOSID
ASE

(Bacteroides
thetaiotaomicron) 		PF13088
(BNR_2) 		4 GLU A 638
PHE A 634
TYR A1016
HIS A 683
 None
 1.41A 4a97J-5mqsA:
undetectable		 4a97J-5mqsA:
14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5opq 3,6-ANHYDRO-D-GALACT
OSIDASE

(Zobellia
galactanivorans) 		no annotation 4 GLU A 521
PHE A 317
TYR A 307
HIS A 293
 None
 1.32A 4a97J-5opqA:
undetectable		 4a97J-5opqA:
14.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t1p ABC TRANSPORTER,
PERIPLASMIC
SUBSTRATE-BINDING
PROTEIN

(Campylobacter
jejuni) 		PF13343
(SBP_bac_6) 		4 GLU A 276
PHE A 277
TYR A 112
HIS A 299
 None
 1.13A 4a97J-5t1pA:
undetectable		 4a97J-5t1pA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tz8 GLYCOSYL TRANSFERASE

(Staphylococcus
aureus) 		PF00535
(Glycos_transf_2) 		4 GLU A 443
GLU A 434
PHE A 432
TYR A 399
 None
 1.03A 4a97J-5tz8A:
undetectable		 4a97J-5tz8A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u02 GLYCOSYL TRANSFERASE

(Staphylococcus
aureus) 		no annotation 4 GLU A 443
GLU A 434
PHE A 432
TYR A 399
 None
 1.07A 4a97J-5u02A:
undetectable		 4a97J-5u02A:
24.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vil MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 5

(Homo sapiens) 		no annotation 4 GLU A 746
GLU A 710
PHE A 744
TYR A 675
 None
 1.43A 4a97J-5vilA:
undetectable		 4a97J-5vilA:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xea ENVELOPE
GLYCOPROTEIN

(Thogoto
thogotovirus) 		PF03273
(Baculo_gp64) 		4 GLU A  57
PHE A 212
TYR A 259
HIS A 257
 None
 1.47A 4a97J-5xeaA:
undetectable		 4a97J-5xeaA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xzb CYCLIC GMP-AMP
SYNTHASE

(Mus musculus) 		PF03281
(Mab-21) 		4 GLU A 202
GLU A 371
TYR A 421
HIS A 422
 None
None
A9Y  A 602 (-4.0A)
A9Y  A 602 ( 4.5A)
 1.45A 4a97J-5xzbA:
undetectable		 4a97J-5xzbA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bq1 PHOSPHATIDYLINOSITOL
4-KINASE III ALPHA
(PI4KA)

(Homo sapiens) 		no annotation 4 GLU A1376
PHE A1383
TYR A1485
HIS A1482
 None
 1.49A 4a97J-6bq1A:
undetectable		 4a97J-6bq1A:
0.00