SIMILAR PATTERNS OF AMINO ACIDS FOR 4A97_J_ZPCJ1318
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1air | PECTATE LYASE C (Dickeyachrysanthemi) |
PF00544(Pec_lyase_C) | 4 | PHE A 103VAL A 82ILE A 33GLU A 60 | None | 1.02A | 4a97I-1airA:undetectable | 4a97I-1airA:20.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1c4k | PROTEIN (ORNITHINEDECARBOXYLASE) (Lactobacillussp. 30A) |
PF01276(OKR_DC_1)PF03709(OKR_DC_1_N)PF03711(OKR_DC_1_C) | 4 | VAL A 664ARG A 245ILE A 251GLU A 671 | None | 1.08A | 4a97I-1c4kA:undetectable | 4a97I-1c4kA:16.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ciy | CRYIA(A) (Bacillusthuringiensis) |
PF00555(Endotoxin_M)PF03944(Endotoxin_C)PF03945(Endotoxin_N) | 4 | PHE A 574TYR A 522VAL A 524ILE A 601 | None | 1.09A | 4a97I-1ciyA:4.1 | 4a97I-1ciyA:20.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1eth | TRIACYLGLYCEROLACYL-HYDROLASE (Sus scrofa) |
PF00151(Lipase)PF01477(PLAT) | 4 | PHE A 387TYR A 341VAL A 343ILE A 419 | None | 0.99A | 4a97I-1ethA:0.0 | 4a97I-1ethA:22.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1f82 | BOTULINUM NEUROTOXINTYPE B (Clostridiumbotulinum) |
PF01742(Peptidase_M27) | 4 | PHE A 154VAL A 135ARG A 27ILE A 132 | None | 1.05A | 4a97I-1f82A:0.0 | 4a97I-1f82A:20.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1hnf | CD2 (Homo sapiens) |
PF05790(C2-set)PF07686(V-set) | 4 | PHE A 98TYR A 81VAL A 83ILE A 33 | None NA A 629 (-4.7A)NoneNone | 0.86A | 4a97I-1hnfA:undetectable | 4a97I-1hnfA:17.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1jc9 | TECHYLECTIN-5A (Tachypleustridentatus) |
PF00147(Fibrinogen_C) | 4 | TYR A 79VAL A 78ILE A 65GLU A 256 | None | 1.04A | 4a97I-1jc9A:undetectable | 4a97I-1jc9A:21.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1kfu | M-CALPAIN LARGESUBUNIT (Homo sapiens) |
PF00648(Peptidase_C2)PF01067(Calpain_III)PF13833(EF-hand_8) | 4 | PHE L 475VAL L 409ILE L 499GLU L 460 | None | 0.79A | 4a97I-1kfuL:0.0 | 4a97I-1kfuL:17.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1lpb | LIPASE (Homo sapiens) |
PF00151(Lipase)PF01477(PLAT) | 4 | PHE B 386TYR B 340VAL B 342ILE B 420 | None | 0.89A | 4a97I-1lpbB:0.0 | 4a97I-1lpbB:20.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1nba | N-CARBAMOYLSARCOSINEAMIDOHYDROLASE (Arthrobactersp.) |
PF00857(Isochorismatase) | 4 | VAL A 75MET A 68ILE A 71GLU A 139 | None | 0.80A | 4a97I-1nbaA:undetectable | 4a97I-1nbaA:19.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1nbq | JUNCTIONAL ADHESIONMOLECULE 1 (Homo sapiens) |
PF07686(V-set)PF13927(Ig_3) | 4 | PHE A 55TYR A 52VAL A 31GLU A 113 | None | 1.09A | 4a97I-1nbqA:undetectable | 4a97I-1nbqA:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1nf2 | PHOSPHATASE (Thermotogamaritima) |
PF08282(Hydrolase_3) | 4 | TYR A 36VAL A 38ILE A 63GLU A 208 | None | 1.02A | 4a97I-1nf2A:undetectable | 4a97I-1nf2A:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1nt2 | FIBRILLARIN-LIKEPRE-RRNA PROCESSINGPROTEIN (Archaeoglobusfulgidus) |
PF01269(Fibrillarin) | 4 | TYR A 208VAL A 157ILE A 130GLU A 184 | None | 1.06A | 4a97I-1nt2A:undetectable | 4a97I-1nt2A:21.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qfh | PROTEIN (GELATIONFACTOR) (Dictyosteliumdiscoideum) |
PF00630(Filamin) | 4 | TYR A 727VAL A 745MET A 741ILE A 743 | None | 1.09A | 4a97I-1qfhA:2.2 | 4a97I-1qfhA:19.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qjo | DIHYDROLIPOAMIDEACETYLTRANSFERASE (Escherichiacoli) |
PF00364(Biotin_lipoyl) | 4 | VAL A 65MET A 72ILE A 71GLU A 38 | None | 0.99A | 4a97I-1qjoA:undetectable | 4a97I-1qjoA:15.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vpk | DNA POLYMERASE III,BETA SUBUNIT (Thermotogamaritima) |
PF00712(DNA_pol3_beta)PF02767(DNA_pol3_beta_2)PF02768(DNA_pol3_beta_3) | 4 | PHE A 68VAL A 70MET A 78ILE A 75 | None | 1.06A | 4a97I-1vpkA:undetectable | 4a97I-1vpkA:23.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wxx | HYPOTHETICAL PROTEINTTHA1280 (Thermusthermophilus) |
PF10672(Methyltrans_SAM) | 5 | PHE A 335TYR A 304VAL A 339ILE A 312ASN A 308 | None | 1.35A | 4a97I-1wxxA:undetectable | 4a97I-1wxxA:22.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xl3 | PROTEIN TYPE A (Yersinia pestis) |
PF09059(TyeA) | 4 | PHE C 60VAL C 16MET C 9ILE C 12 | None | 1.07A | 4a97I-1xl3C:4.4 | 4a97I-1xl3C:15.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xmx | HYPOTHETICAL PROTEINVC1899 (Vibrio cholerae) |
PF09002(DUF1887) | 4 | PHE A 106TYR A 109VAL A 87ILE A 3 | None | 0.92A | 4a97I-1xmxA:undetectable | 4a97I-1xmxA:22.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1yal | CHYMOPAPAIN (Carica papaya) |
PF00112(Peptidase_C1) | 4 | VAL A 161MET A 191ILE A 177ASN A 179 | None | 0.91A | 4a97I-1yalA:undetectable | 4a97I-1yalA:20.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2e18 | NH(3)-DEPENDENTNAD(+) SYNTHETASE (Pyrococcushorikoshii) |
PF02540(NAD_synthase) | 4 | TYR A 197VAL A 161ILE A 153ASN A 131 | NoneNoneNone ZN A1305 ( 4.9A) | 0.98A | 4a97I-2e18A:undetectable | 4a97I-2e18A:21.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2eaa | 7S GLOBULIN-3 (Vigna angularis) |
PF00190(Cupin_1) | 4 | PHE A 47TYR A 60VAL A 62ILE A 134 | None | 0.89A | 4a97I-2eaaA:undetectable | 4a97I-2eaaA:19.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2eo4 | 150AA LONGHYPOTHETICALHISTIDINE TRIADNUCLEOTIDE-BINDINGPROTEIN (Sulfurisphaeratokodaii) |
PF01230(HIT) | 4 | PHE A 111TYR A 107VAL A 73ILE A 69 | None | 1.06A | 4a97I-2eo4A:undetectable | 4a97I-2eo4A:16.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ija | ARYLAMINEN-ACETYLTRANSFERASE1 (Homo sapiens) |
PF00797(Acetyltransf_2) | 4 | TYR A 94VAL A 93ILE A 106GLU A 182 | UNX A 502 (-4.3A)NoneNoneNone | 1.04A | 4a97I-2ijaA:undetectable | 4a97I-2ijaA:24.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qc7 | ENDOPLASMICRETICULUM PROTEINERP29 (Homo sapiens) |
PF07749(ERp29)PF07912(ERp29_N) | 4 | PHE A 46VAL A 91ILE A 93ASN A 101 | None | 1.05A | 4a97I-2qc7A:2.8 | 4a97I-2qc7A:20.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qn0 | NEUROTOXIN (Clostridiumbotulinum) |
PF01742(Peptidase_M27) | 4 | TYR A 202VAL A 379ILE A 256GLU A 360 | None | 0.90A | 4a97I-2qn0A:undetectable | 4a97I-2qn0A:22.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2uut | RNA-DIRECTED RNAPOLYMERASE (Sapporo virus) |
PF00680(RdRP_1) | 4 | PHE A 337TYR A 90VAL A 87ILE A 261 | None | 1.09A | 4a97I-2uutA:undetectable | 4a97I-2uutA:20.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2w8s | PHOSPHONATEMONOESTER HYDROLASE (Paraburkholderiacaryophylli) |
PF00884(Sulfatase)PF16347(DUF4976) | 4 | TYR A 340VAL A 439ILE A 440GLU A 343 | None | 0.99A | 4a97I-2w8sA:undetectable | 4a97I-2w8sA:19.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2z3k | LEUCYL/PHENYLALANYL-TRNA-PROTEINTRANSFERASE (Escherichiacoli) |
PF03588(Leu_Phe_trans) | 4 | TYR A 87VAL A 89MET A 144ILE A 132 | NoneNonePHE A 302 ( 3.6A)None | 0.86A | 4a97I-2z3kA:undetectable | 4a97I-2z3kA:20.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2zi8 | PROBABLEBIPHENYL-2,3-DIOL1,2-DIOXYGENASE BPHC (Mycobacteriumtuberculosis) |
PF00903(Glyoxalase) | 4 | PHE A 136VAL A 218MET A 257ILE A 265 | None | 0.96A | 4a97I-2zi8A:undetectable | 4a97I-2zi8A:21.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ahi | XYLULOSE5-PHOSPHATE/FRUCTOSE6-PHOSPHATEPHOSPHOKETOLASE (Bifidobacteriumbreve) |
PF03894(XFP)PF09363(XFP_C)PF09364(XFP_N) | 4 | PHE A 504TYR A 501ASN A 549GLU A 479 | None | 1.08A | 4a97I-3ahiA:undetectable | 4a97I-3ahiA:16.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ai7 | XYLULOSE-5-PHOSPHATE/FRUCTOSE-6-PHOSPHATE PHOSPHOKETOLASE (Bifidobacteriumlongum) |
PF03894(XFP)PF09363(XFP_C)PF09364(XFP_N) | 4 | PHE A 504TYR A 501ASN A 549GLU A 479 | None | 1.10A | 4a97I-3ai7A:undetectable | 4a97I-3ai7A:15.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3al8 | SEMAPHORIN-6A (Mus musculus) |
PF01403(Sema)PF01437(PSI) | 4 | PHE A 291TYR A 292ILE A 295ASN A 294 | None | 1.10A | 4a97I-3al8A:undetectable | 4a97I-3al8A:21.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bm3 | PSPGI RESTRICTIONENDONUCLEASE (Pyrococcus sp.GI-H) |
PF09019(EcoRII-C) | 4 | PHE A 104VAL A 159ILE A 157GLU A 60 | None | 0.89A | 4a97I-3bm3A:4.4 | 4a97I-3bm3A:23.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dfy | MUCONATECYCLOISOMERASE (Thermotogamaritima) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 4 | PHE A 201VAL A 173ARG A 143ILE A 176 | None | 1.07A | 4a97I-3dfyA:undetectable | 4a97I-3dfyA:24.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dg8 | BIFUNCTIONALDIHYDROFOLATEREDUCTASE-THYMIDYLATE SYNTHASE (Plasmodiumfalciparum) |
PF00186(DHFR_1) | 4 | VAL A 140MET A 104ILE A 126ASN A 124 | NoneRJ6 A 609 ( 4.0A)NoneNone | 0.95A | 4a97I-3dg8A:undetectable | 4a97I-3dg8A:20.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3do9 | UPF0302 PROTEINBA_1542/GBAA1542/BAS1430 (Bacillusanthracis) |
PF08858(IDEAL)PF08864(UPF0302) | 4 | TYR A 98ARG A 56ILE A 89GLU A 117 | None | 1.06A | 4a97I-3do9A:undetectable | 4a97I-3do9A:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dwl | ACTIN-RELATEDPROTEIN 2/3 COMPLEXSUBUNIT 4 (Schizosaccharomycespombe) |
PF05856(ARPC4) | 4 | PHE F 138VAL F 142MET F 149ILE F 146 | None | 1.09A | 4a97I-3dwlF:undetectable | 4a97I-3dwlF:20.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ehf | SENSOR KINASE (YOCFPROTEIN) (Bacillussubtilis) |
PF07730(HisKA_3) | 4 | PHE A 264VAL A 305MET A 363ILE A 316 | None | 1.06A | 4a97I-3ehfA:4.5 | 4a97I-3ehfA:21.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ejg | NON-STRUCTURALPROTEIN 3 (Humancoronavirus229E) |
PF01661(Macro) | 4 | PHE A 6TYR A 15VAL A 150ILE A 120 | None | 0.99A | 4a97I-3ejgA:undetectable | 4a97I-3ejgA:16.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3eo6 | PROTEIN OF UNKNOWNFUNCTION (DUF1255) (Acidithiobacillusferrooxidans) |
PF06865(DUF1255) | 4 | VAL A 59MET A 83ILE A 57GLU A 97 | None | 1.00A | 4a97I-3eo6A:undetectable | 4a97I-3eo6A:14.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ewr | NON-STRUCTURALPROTEIN 3 (Humancoronavirus229E) |
PF01661(Macro) | 4 | PHE A 7TYR A 16VAL A 151ILE A 121 | NoneNoneAPR A 169 ( 4.6A)None | 0.94A | 4a97I-3ewrA:undetectable | 4a97I-3ewrA:19.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3eya | PYRUVATEDEHYDROGENASE[CYTOCHROME] (Escherichiacoli) |
PF00205(TPP_enzyme_M)PF02775(TPP_enzyme_C)PF02776(TPP_enzyme_N) | 4 | TYR A 200MET A 306ILE A 289GLU A 324 | None | 1.02A | 4a97I-3eyaA:undetectable | 4a97I-3eyaA:19.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fbu | ACETYLTRANSFERASE,GNAT FAMILY (Bacillusanthracis) |
PF13302(Acetyltransf_3) | 4 | PHE A 90VAL A 61MET A 1ILE A 10 | COA A 169 (-4.6A)NoneNoneNone | 1.05A | 4a97I-3fbuA:undetectable | 4a97I-3fbuA:19.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ffh | HISTIDINOL-PHOSPHATEAMINOTRANSFERASE (Listeriainnocua) |
PF00155(Aminotran_1_2) | 4 | TYR A 233VAL A 90ILE A 94GLU A 195 | NoneSO4 A 361 (-3.5A)NoneNone | 1.08A | 4a97I-3ffhA:undetectable | 4a97I-3ffhA:23.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ib5 | SEX PHEROMONEPRECURSOR (Lactobacillussalivarius) |
PF07537(CamS) | 4 | TYR A 146VAL A 147MET A 227ILE A 172 | None | 0.81A | 4a97I-3ib5A:undetectable | 4a97I-3ib5A:20.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ihp | UBIQUITINCARBOXYL-TERMINALHYDROLASE 5 (Homo sapiens) |
PF00443(UCH)PF00627(UBA)PF02148(zf-UBP) | 4 | PHE A 461TYR A 568VAL A 570ILE A 827 | None | 1.09A | 4a97I-3ihpA:undetectable | 4a97I-3ihpA:17.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3j82 | C-TYPE LECTIN DOMAINFAMILY 9 MEMBER A (Mus musculus) |
PF00059(Lectin_C) | 4 | TYR A 236VAL A 198MET A 181ILE A 175 | None | 1.02A | 4a97I-3j82A:undetectable | 4a97I-3j82A:15.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3k2n | SIGMA-54-DEPENDENTTRANSCRIPTIONALREGULATOR (Chlorobaculumtepidum) |
PF13185(GAF_2) | 4 | PHE A 59VAL A 135ILE A 117GLU A 60 | None | 1.08A | 4a97I-3k2nA:3.4 | 4a97I-3k2nA:20.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kq0 | ALPHA-1-ACIDGLYCOPROTEIN 1 (Homo sapiens) |
PF00061(Lipocalin) | 4 | PHE A 32TYR A 37VAL A 41ILE A 44 | None | 1.00A | 4a97I-3kq0A:undetectable | 4a97I-3kq0A:19.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ltf | PROTEIN SPITZ (Drosophilamelanogaster) |
no annotation | 4 | PHE D 23VAL D 25ILE D 27GLU D 36 | None | 0.92A | 4a97I-3ltfD:undetectable | 4a97I-3ltfD:10.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ml6 | CHIMERIC COMPLEXBETWEEN PROTEINDISHEVLLED2 HOMOLOGDVL-2 AND CLATHRINADAPTOR AP-2 COMPLEXSUBUNIT MU (Mus musculus;Rattusnorvegicus) |
PF00610(DEP)PF00928(Adap_comp_sub) | 4 | PHE A 469TYR A 463VAL A 466MET A 430 | None | 1.05A | 4a97I-3ml6A:2.0 | 4a97I-3ml6A:21.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3muq | UNCHARACTERIZEDCONSERVED PROTEIN (Vibrioparahaemolyticus) |
PF12849(PBP_like_2) | 4 | PHE A 91TYR A 96VAL A 225ILE A 233 | None | 1.10A | 4a97I-3muqA:undetectable | 4a97I-3muqA:21.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3noy | 4-HYDROXY-3-METHYLBUT-2-EN-1-YLDIPHOSPHATE SYNTHASE (Aquifexaeolicus) |
PF04551(GcpE) | 4 | PHE A 163VAL A 127MET A 93ILE A 100 | None | 0.91A | 4a97I-3noyA:undetectable | 4a97I-3noyA:21.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3noy | 4-HYDROXY-3-METHYLBUT-2-EN-1-YLDIPHOSPHATE SYNTHASE (Aquifexaeolicus) |
PF04551(GcpE) | 4 | VAL A 127MET A 93ILE A 100GLU A 164 | None | 1.10A | 4a97I-3noyA:undetectable | 4a97I-3noyA:21.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pco | PHENYLALANYL-TRNASYNTHETASE, BETACHAIN (Escherichiacoli) |
PF01588(tRNA_bind)PF03147(FDX-ACB)PF03483(B3_4)PF03484(B5) | 4 | VAL B 250ILE B 246ASN B 254GLU B 334 | None | 1.01A | 4a97I-3pcoB:undetectable | 4a97I-3pcoB:17.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3um6 | BIFUNCTIONALDIHYDROFOLATEREDUCTASE-THYMIDYLATE SYNTHASE (Plasmodiumfalciparum) |
PF00186(DHFR_1)PF00303(Thymidylat_synt) | 4 | VAL A 140MET A 104ILE A 126ASN A 124 | None1CY A 609 ( 4.5A)NoneNone | 0.81A | 4a97I-3um6A:undetectable | 4a97I-3um6A:17.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3v9e | LACCASE (Botrytis aclada) |
PF00394(Cu-oxidase)PF07731(Cu-oxidase_2)PF07732(Cu-oxidase_3) | 4 | PHE A 393TYR A 397VAL A 399GLU A 390 | None | 1.01A | 4a97I-3v9eA:undetectable | 4a97I-3v9eA:19.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vtz | GLUCOSE1-DEHYDROGENASE (Thermoplasmavolcanium) |
PF13561(adh_short_C2) | 4 | TYR A 109VAL A 105ILE A 101ASN A 106 | None | 0.91A | 4a97I-3vtzA:undetectable | 4a97I-3vtzA:22.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vys | HYDROGENASEEXPRESSION/FORMATIONPROTEIN HYPD (Thermococcuskodakarensis) |
PF01924(HypD) | 4 | VAL B 58ILE B 32ASN B 57GLU B 19 | None | 0.97A | 4a97I-3vysB:undetectable | 4a97I-3vysB:18.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wcy | INTERFERONALPHA/BETA RECEPTOR1 (Mus musculus) |
PF01108(Tissue_fac)PF09294(Interfer-bind) | 4 | TYR A 370VAL A 372MET A 352ILE A 339 | None | 0.96A | 4a97I-3wcyA:2.0 | 4a97I-3wcyA:21.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wiq | KOJIBIOSEPHOSPHORYLASE (Caldicellulosiruptorsaccharolyticus) |
PF03632(Glyco_hydro_65m)PF03633(Glyco_hydro_65C)PF03636(Glyco_hydro_65N) | 4 | PHE A 655VAL A 307ILE A 311ASN A 310 | None | 0.92A | 4a97I-3wiqA:3.0 | 4a97I-3wiqA:16.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bwf | UBIQUITIN-CONJUGATING ENZYME E2-21 KDA (Saccharomycescerevisiae) |
PF00179(UQ_con) | 4 | ARG A 177ILE A 102ASN A 101GLU A 62 | None | 0.93A | 4a97I-4bwfA:undetectable | 4a97I-4bwfA:19.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4eg9 | UNCHARACTERIZEDPROTEINSAOUHSC_02783 (Staphylococcusaureus) |
PF04507(DUF576) | 4 | VAL A 95ILE A 75ASN A 77GLU A 126 | None | 0.74A | 4a97I-4eg9A:undetectable | 4a97I-4eg9A:19.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fyc | THIOL:DISULFIDEINTERCHANGE PROTEIN(DSBC) (Helicobacterpylori) |
PF13098(Thioredoxin_2) | 4 | PHE A 67TYR A 116VAL A 83ILE A 158 | None | 0.97A | 4a97I-4fycA:undetectable | 4a97I-4fycA:19.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hpf | POTASSIUM CHANNELSUBFAMILY U MEMBER 1 (Homo sapiens) |
PF03493(BK_channel_a) | 4 | TYR A 917ILE A 472ASN A 471GLU A 558 | None | 1.09A | 4a97I-4hpfA:undetectable | 4a97I-4hpfA:18.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jz7 | CARBAMATE KINASE (Giardiaintestinalis) |
PF00696(AA_kinase) | 4 | VAL A 49MET A 233ILE A 9GLU A 106 | None | 1.06A | 4a97I-4jz7A:undetectable | 4a97I-4jz7A:21.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4p27 | VENOM ALLERGEN-LIKE(VAL) 4 PROTEIN (Schistosomamansoni) |
PF00188(CAP) | 4 | PHE A 14VAL A 18ILE A 27GLU A 85 | None | 1.00A | 4a97I-4p27A:undetectable | 4a97I-4p27A:18.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4p68 | DIHYDROFOLATEREDUCTASE (Escherichiacoli) |
PF00186(DHFR_1) | 4 | VAL A 72MET A 42ILE A 61ASN A 59 | NoneNoneNoneXCN A 54 ( 3.0A) | 0.83A | 4a97I-4p68A:undetectable | 4a97I-4p68A:19.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4q8k | ALGINASE (Pseudoalteromonassp. SM0524) |
PF08787(Alginate_lyase2) | 4 | PHE A 239TYR A 395VAL A 393ILE A 175 | None | 1.00A | 4a97I-4q8kA:undetectable | 4a97I-4q8kA:22.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4q8l | ALGINASE (Pseudoalteromonassp. SM0524) |
PF08787(Alginate_lyase2) | 4 | PHE A 72TYR A 228VAL A 226ILE A 8 | None | 0.98A | 4a97I-4q8lA:undetectable | 4a97I-4q8lA:21.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qni | UNCHARACTERIZEDPROTEIN (Bacteroidesthetaiotaomicron) |
PF14274(DUF4361)PF16343(DUF4973) | 4 | TYR A 328VAL A 330ILE A 200ASN A 202 | NoneNoneEDO A 403 ( 4.1A)EDO A 403 ( 4.9A) | 1.05A | 4a97I-4qniA:undetectable | 4a97I-4qniA:20.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rep | GAMMA-CAROTENEDESATURASE (Nonlabensdokdonensis) |
PF01593(Amino_oxidase) | 4 | VAL A 257MET A 286ILE A 250GLU A 486 | None | 1.05A | 4a97I-4repA:undetectable | 4a97I-4repA:20.16 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4twf | CYS-LOOPLIGAND-GATED IONCHANNEL (Dickeyachrysanthemi) |
PF02931(Neur_chan_LBD) | 6 | PHE A 19TYR A 38VAL A 40ARG A 91MET A 93ILE A 101 | None | 0.57A | 4a97I-4twfA:33.9 | 4a97I-4twfA:99.35 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4twf | CYS-LOOPLIGAND-GATED IONCHANNEL (Dickeyachrysanthemi) |
PF02931(Neur_chan_LBD) | 5 | PHE A 19VAL A 40ARG A 91MET A 93ASN A 103 | None | 0.99A | 4a97I-4twfA:33.9 | 4a97I-4twfA:99.35 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4twf | CYS-LOOPLIGAND-GATED IONCHANNEL (Dickeyachrysanthemi) |
PF02931(Neur_chan_LBD) | 4 | TYR A 38ARG A 91MET A 93GLU A 150 | None | 0.78A | 4a97I-4twfA:33.9 | 4a97I-4twfA:99.35 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4yeu | CYS-LOOPLIGAND-GATED IONCHANNEL,PROTON-GATEDION CHANNEL (Dickeyachrysanthemi;Gloeobacterviolaceus) |
PF02931(Neur_chan_LBD) | 7 | PHE A 19TYR A 38VAL A 40ARG A 91MET A 93ILE A 101ASN A 103 | None | 0.60A | 4a97I-4yeuA:29.5 | 4a97I-4yeuA:71.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5aee | ALPHA-GLUCOSIDASEYIHQ (Escherichiacoli) |
PF01055(Glyco_hydro_31) | 4 | PHE A 530VAL A 564ARG A 560ILE A 678 | None | 0.92A | 4a97I-5aeeA:undetectable | 4a97I-5aeeA:17.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5bsz | N-METHYLTRANSFERASE (Streptoalloteichussp. ATCC 53650) |
PF13649(Methyltransf_25) | 4 | VAL A 182ARG A 184ILE A 179GLU A 124 | NoneEDO A 302 ( 4.4A)NoneNone | 1.02A | 4a97I-5bszA:undetectable | 4a97I-5bszA:20.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5czz | CRISPR-ASSOCIATEDENDONUCLEASE CAS9 (Staphylococcusaureus) |
PF13395(HNH_4)PF16592(Cas9_REC) | 4 | ARG A 980ILE A 982ASN A 995GLU A1006 | None | 0.97A | 4a97I-5czzA:undetectable | 4a97I-5czzA:13.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dxv | RETHREADED DHFR (syntheticconstruct) |
PF00186(DHFR_1) | 4 | VAL A 89MET A 59ILE A 78ASN A 76 | None | 0.77A | 4a97I-5dxvA:undetectable | 4a97I-5dxvA:18.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5e9o | CELLULASE, GLYCOSYLHYDROLASE FAMILY 5,TPS LINKER, DOMAIN X (Spirochaetathermophila) |
no annotation | 4 | TYR A 526ILE A 517ASN A 503GLU A 461 | None | 1.01A | 4a97I-5e9oA:undetectable | 4a97I-5e9oA:14.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5flz | SPINDLE POLE BODYCOMPONENT SPC98 (Saccharomycescerevisiae) |
PF04130(Spc97_Spc98) | 4 | TYR B 187VAL B 188ILE B 224GLU B 182 | None | 0.95A | 4a97I-5flzB:2.8 | 4a97I-5flzB:15.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ii5 | MALTOSE-BINDINGPERIPLASMICPROTEIN,VITELLINEENVELOPE SPERM LYSINRECEPTOR (Escherichiacoli;Haliotisrufescens) |
PF11386(VERL)PF13416(SBP_bac_8) | 4 | PHE A4106VAL A4123MET A4077ILE A4070 | None | 0.86A | 4a97I-5ii5A:3.0 | 4a97I-5ii5A:19.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5iuj | SENSOR HISTIDINEKINASE DESK (Bacillussubtilis) |
PF07730(HisKA_3) | 4 | PHE A 264VAL A 305MET A 363ILE A 316 | None | 1.06A | 4a97I-5iujA:3.1 | 4a97I-5iujA:22.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jb3 | 30S RIBOSOMALPROTEIN S3 (Pyrococcusabyssi) |
PF00189(Ribosomal_S3_C)PF07650(KH_2) | 4 | TYR Z 166VAL Z 180ILE Z 130GLU Z 22 | G 21010 ( 4.4A)NoneNoneNone | 1.05A | 4a97I-5jb3Z:undetectable | 4a97I-5jb3Z:20.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5l0l | UNCHARACTERIZEDPROTEIN (Legionellapneumophila) |
no annotation | 4 | TYR A 130VAL A 132MET A 224ILE A 144 | None | 0.77A | 4a97I-5l0lA:undetectable | 4a97I-5l0lA:18.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5lmg | DNA TOPOISOMERASE2-ASSOCIATED PROTEINPAT1 (Saccharomycescerevisiae) |
PF09770(PAT1) | 4 | PHE A 681VAL A 727ILE A 724GLU A 701 | NoneNoneNoneEDO A 804 (-2.9A) | 1.08A | 4a97I-5lmgA:2.9 | 4a97I-5lmgA:22.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mc5 | XAA-PRO DIPEPTIDASE (Homo sapiens) |
no annotation | 4 | PHE A 96TYR A 83VAL A 85ILE A 45 | None | 0.64A | 4a97I-5mc5A:undetectable | 4a97I-5mc5A:14.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mpd | 26S PROTEASOMEREGULATORY SUBUNITRPN6 (Saccharomycescerevisiae) |
PF01399(PCI) | 4 | VAL Q 302MET Q 271ILE Q 270GLU Q 322 | None | 0.86A | 4a97I-5mpdQ:2.3 | 4a97I-5mpdQ:21.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5n0l | GTP-SENSINGTRANSCRIPTIONALPLEIOTROPICREPRESSOR CODY (Clostridioidesdifficile) |
no annotation | 4 | PHE A 74TYR A 78VAL A 82ILE A 85 | ILE A 201 ( 4.7A)NoneNoneNone | 1.04A | 4a97I-5n0lA:undetectable | 4a97I-5n0lA:15.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5te1 | ATP-CITRATE SYNTHASE (Homo sapiens) |
PF00549(Ligase_CoA)PF02629(CoA_binding)PF16114(Citrate_bind) | 4 | PHE A 493VAL A 568ILE A 591GLU A 683 | None | 1.04A | 4a97I-5te1A:undetectable | 4a97I-5te1A:16.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5tet | ATP-CITRATE SYNTHASE (Homo sapiens) |
PF00549(Ligase_CoA)PF02629(CoA_binding) | 4 | PHE B 493VAL B 568ILE B 591GLU B 683 | None | 1.05A | 4a97I-5tetB:undetectable | 4a97I-5tetB:19.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5tph | DE NOVO NTF2HOMODIMER (syntheticconstruct) |
PF12680(SnoaL_2) | 4 | PHE A 42VAL A 37MET A 89ILE A 107 | None | 0.94A | 4a97I-5tphA:undetectable | 4a97I-5tphA:17.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5trv | DENOVO NTF2 (syntheticconstruct) |
PF12680(SnoaL_2) | 4 | PHE A 41VAL A 36MET A 88ILE A 106 | PEG A 201 (-4.3A)NoneNoneNone | 1.01A | 4a97I-5trvA:undetectable | 4a97I-5trvA:17.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5uwb | TOLUENE TOLERANCEPROTEIN (Pseudomonasputida) |
no annotation | 4 | TYR B 144VAL B 164ILE B 167ASN B 165 | PEF B 302 (-4.0A)PEF B 302 ( 4.6A)NonePEF B 302 ( 4.1A) | 1.03A | 4a97I-5uwbB:undetectable | 4a97I-5uwbB:19.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5yfb | DIPEPTIDYL PEPTIDASE3 (Armillariatabescens) |
no annotation | 4 | TYR A 313VAL A 314ILE A 164GLU A 324 | None | 0.95A | 4a97I-5yfbA:undetectable | 4a97I-5yfbA:13.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6d46 | BETA SLIDING CLAMP (Rickettsiatyphi) |
no annotation | 4 | PHE A 353TYR A 352VAL A 362ILE A 376 | None | 1.01A | 4a97I-6d46A:undetectable | 4a97I-6d46A:17.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6f36 | MITOCHONDRIAL ATPSYNTHASE SUBUNITASA6 (Polytomella sp.Pringsheim198.80) |
no annotation | 4 | PHE N 129TYR N 126VAL N 125ILE N 120 | None | 1.08A | 4a97I-6f36N:undetectable | 4a97I-6f36N:14.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6fhs | ARP5 (Chaetomiumthermophilum) |
no annotation | 4 | VAL J 68MET J 158ILE J 61ASN J 63 | None | 0.82A | 4a97I-6fhsJ:undetectable | 4a97I-6fhsJ:15.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1gbg | (1,3-1,4)-BETA-D-GLUCAN 4GLUCANOHYDROLASE (Bacilluslicheniformis) |
PF00722(Glyco_hydro_16) | 4 | GLU A 46PHE A 10TYR A 144HIS A 145 | None | 1.06A | 4a97J-1gbgA:0.0 | 4a97J-1gbgA:20.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1gxl | CHROMOSOMESEGREGATION SMCPROTEIN (Thermotogamaritima) |
PF06470(SMC_hinge) | 4 | GLU A 587GLU A 589PHE A 592TYR A 633 | None | 1.36A | 4a97J-1gxlA:0.0 | 4a97J-1gxlA:21.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1l9x | GAMMA-GLUTAMYLHYDROLASE (Homo sapiens) |
PF07722(Peptidase_C26) | 4 | GLU A 227GLU A 222PHE A 287HIS A 171 | None | 1.44A | 4a97J-1l9xA:0.0 | 4a97J-1l9xA:20.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wdt | ELONGATION FACTOR GHOMOLOG (Thermusthermophilus) |
PF00009(GTP_EFTU)PF00679(EFG_C)PF03764(EFG_IV)PF14492(EFG_II) | 4 | GLU A 419PHE A 528TYR A 646HIS A 645 | None | 1.32A | 4a97J-1wdtA:0.0 | 4a97J-1wdtA:17.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zbt | PEPTIDE CHAINRELEASE FACTOR 1 (Streptococcusmutans) |
PF00472(RF-1)PF03462(PCRF) | 4 | GLU A 152GLU A 257TYR A 228HIS A 229 | None | 1.40A | 4a97J-1zbtA:0.0 | 4a97J-1zbtA:19.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2j4x | MITOGEN (Streptococcusdysgalactiae) |
PF02876(Stap_Strp_tox_C) | 4 | GLU A 191PHE A 136TYR A 171HIS A 170 | NoneNoneNone ZN A1211 (-3.1A) | 1.22A | 4a97J-2j4xA:0.0 | 4a97J-2j4xA:20.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2n2h | PAIRED AMPHIPATHICHELIX PROTEIN SIN3ASIN3 HISTONEDEACETYLASECOREPRESSOR COMPLEXCOMPONENT SDS3 (Mus musculus) |
PF08295(Sin3_corepress)no annotation | 4 | GLU B 616GLU B 619PHE B 714TYR A 209 | None | 1.37A | 4a97J-2n2hB:undetectable | 4a97J-2n2hB:14.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qml | BH2621 PROTEIN (Bacillushalodurans) |
PF13523(Acetyltransf_8) | 4 | GLU A 85PHE A 63TYR A 56HIS A 39 | None | 1.41A | 4a97J-2qmlA:undetectable | 4a97J-2qmlA:20.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vmf | BETA-MANNOSIDASE (Bacteroidesthetaiotaomicron) |
PF00703(Glyco_hydro_2) | 4 | GLU A 90PHE A 156TYR A 153HIS A 151 | EDO A1875 (-3.3A)NoneNoneNone | 1.02A | 4a97J-2vmfA:undetectable | 4a97J-2vmfA:17.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vzn | VENOM ALLERGEN 3 (Solenopsisinvicta) |
PF00188(CAP) | 4 | GLU A 62PHE A 142TYR A 136HIS A 50 | None | 1.43A | 4a97J-2vznA:undetectable | 4a97J-2vznA:19.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2w8s | PHOSPHONATEMONOESTER HYDROLASE (Paraburkholderiacaryophylli) |
PF00884(Sulfatase)PF16347(DUF4976) | 4 | GLU A 466GLU A 441PHE A 458TYR A 412 | None | 1.23A | 4a97J-2w8sA:undetectable | 4a97J-2w8sA:19.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xze | CHARGEDMULTIVESICULAR BODYPROTEIN 3STAM-BINDING PROTEIN (Homo sapiens) |
PF08969(USP8_dimer)no annotation | 4 | GLU Q 206GLU Q 207TYR A 80HIS A 77 | None | 1.30A | 4a97J-2xzeQ:undetectable | 4a97J-2xzeQ:8.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2y6i | COLLAGENASE (Hathewayahistolytica) |
PF01752(Peptidase_M9)PF08453(Peptidase_M9_N) | 4 | GLU A 691GLU A 695TYR A 758HIS A 684 | None | 1.49A | 4a97J-2y6iA:undetectable | 4a97J-2y6iA:14.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bq9 | PREDICTED ROSSMANNFOLDNUCLEOTIDE-BINDINGDOMAIN-CONTAININGPROTEIN (Idiomarinabaltica) |
PF03641(Lysine_decarbox)PF11892(DUF3412)PF14793(DUF4478) | 4 | GLU A 81GLU A 82PHE A 84TYR A 58 | None | 1.10A | 4a97J-3bq9A:undetectable | 4a97J-3bq9A:20.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3d6e | BETA-GLUCANASE (Bacilluslicheniformis) |
PF00722(Glyco_hydro_16) | 4 | GLU A 33PHE A 10TYR A 131HIS A 132 | None | 0.99A | 4a97J-3d6eA:undetectable | 4a97J-3d6eA:19.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3m8n | POSSIBLE GLUTATHIONES-TRANSFERASE (Rhodopseudomonaspalustris) |
PF00043(GST_C)PF02798(GST_N) | 4 | GLU A 103PHE A 111TYR A 166HIS A 168 | None | 1.45A | 4a97J-3m8nA:undetectable | 4a97J-3m8nA:20.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mx3 | SUSD HOMOLOG (Bacteroidesfragilis) |
PF12771(SusD-like_2) | 4 | GLU A 62PHE A 432TYR A 249HIS A 252 | MG A 601 (-2.5A)NoneNoneNone | 1.42A | 4a97J-3mx3A:undetectable | 4a97J-3mx3A:21.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3o5s | BETA-GLUCANASE (Bacillussubtilis) |
PF00722(Glyco_hydro_16) | 4 | GLU A 74PHE A 38TYR A 172HIS A 173 | None | 0.97A | 4a97J-3o5sA:undetectable | 4a97J-3o5sA:18.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3s51 | FANCONI ANEMIA GROUPI PROTEIN HOMOLOG (Mus musculus) |
PF14674(FANCI_S1-cap)PF14675(FANCI_S1)PF14676(FANCI_S2)PF14677(FANCI_S3)PF14678(FANCI_S4)PF14679(FANCI_HD1)PF14680(FANCI_HD2) | 4 | GLU A 750PHE A 808TYR A 840HIS A 839 | None | 1.46A | 4a97J-3s51A:3.0 | 4a97J-3s51A:12.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4a2n | ISOPRENYLCYSTEINECARBOXYLMETHYLTRANSFERASE (Methanosarcinaacetivorans) |
PF04140(ICMT) | 4 | GLU B 42GLU B 167TYR B 129HIS B 131 | NoneSAH B1193 (-3.5A)SAH B1193 (-3.4A)None | 1.16A | 4a97J-4a2nB:undetectable | 4a97J-4a2nB:19.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4f9l | 20.1 ANTI-BTN3A1ANTIBODY FRAGMENT (Mus musculus) |
no annotation | 4 | GLU D 230GLU D 181TYR D 94HIS D 92 | None | 1.49A | 4a97J-4f9lD:undetectable | 4a97J-4f9lD:19.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fk8 | FERREDOXIN--NADPREDUCTASE (Burkholderiathailandensis) |
PF00175(NAD_binding_1)PF00970(FAD_binding_6) | 4 | GLU A 80PHE A 82TYR A 170HIS A 173 | None | 1.47A | 4a97J-4fk8A:undetectable | 4a97J-4fk8A:21.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4tqo | METHANOLDEHYDROGENASEPROTEIN, LARGESUBUNITMETHANOLDEHYDROGENASE, SMALLSUBUNIT (Methylococcuscapsulatus) |
PF02315(MDH)no annotation | 4 | GLU B 171GLU B 170PHE I 86HIS B 147 | None | 1.46A | 4a97J-4tqoB:undetectable | 4a97J-4tqoB:19.86 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4twf | CYS-LOOPLIGAND-GATED IONCHANNEL (Dickeyachrysanthemi) |
PF02931(Neur_chan_LBD) | 4 | GLU A 77GLU A 131PHE A 133TYR A 175 | BR7 A 401 ( 4.9A)BR7 A 401 (-4.1A)BR7 A 401 (-4.5A)BR7 A 401 (-3.9A) | 0.57A | 4a97J-4twfA:33.7 | 4a97J-4twfA:99.35 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4yeu | CYS-LOOPLIGAND-GATED IONCHANNEL,PROTON-GATEDION CHANNEL (Dickeyachrysanthemi;Gloeobacterviolaceus) |
PF02931(Neur_chan_LBD) | 5 | GLU A 77GLU A 131PHE A 133TYR A 175HIS A 177 | None | 0.88A | 4a97J-4yeuA:29.6 | 4a97J-4yeuA:71.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4z81 | EGF FAMILYDOMAIN-CONTAININGPROTEIN (Toxoplasmagondii) |
PF02430(AMA-1)PF07974(EGF_2) | 4 | GLU A 195GLU A 201TYR A 346HIS A 347 | None | 1.24A | 4a97J-4z81A:undetectable | 4a97J-4z81A:19.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zkq | PUTATIVEUNCHARACTERIZEDPROTEIN (Cricetidgammaherpesvirus2) |
no annotation | 4 | GLU A 116GLU A 115PHE A 110HIS A 253 | None | 1.08A | 4a97J-4zkqA:undetectable | 4a97J-4zkqA:21.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5c3m | PUTATIVE6-PHOSPHO-BETA-GLUCOSIDASE (Geobacillusstearothermophilus) |
PF02056(Glyco_hydro_4)PF11975(Glyco_hydro_4C) | 4 | GLU A 270GLU A 271TYR A 260HIS A 202 | NoneNoneNone MN A 501 (-3.4A) | 1.33A | 4a97J-5c3mA:undetectable | 4a97J-5c3mA:19.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5c3m | PUTATIVE6-PHOSPHO-BETA-GLUCOSIDASE (Geobacillusstearothermophilus) |
PF02056(Glyco_hydro_4)PF11975(Glyco_hydro_4C) | 4 | GLU A 270GLU A 271TYR A 260HIS A 258 | None | 1.29A | 4a97J-5c3mA:undetectable | 4a97J-5c3mA:19.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5eio | N-ACETYL-GAMMA-GLUTAMYL-PHOSPHATE/N-ACETYL-GAMMA-AMINOADIPYL-PHOSPHATE REDUCTASE (Thermusthermophilus) |
PF01118(Semialdhyde_dh)PF02774(Semialdhyde_dhC) | 4 | GLU A 250GLU A 296PHE A 295TYR A 279 | None | 1.43A | 4a97J-5eioA:undetectable | 4a97J-5eioA:22.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hpk | E3 UBIQUITIN-PROTEINLIGASE NEDD4-LIKEUBIQUITIN VARIANTNL.1 (Homo sapiens) |
PF00240(ubiquitin)PF00632(HECT) | 4 | GLU B 77GLU A 609TYR A 689HIS A 686 | None | 1.43A | 4a97J-5hpkB:undetectable | 4a97J-5hpkB:14.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5k2m | PROBABLE LYSINEBIOSYNTHESIS PROTEINRIMK-RELATED LYSINEBIOSYNTHESIS PROTEIN (Thermococcuskodakarensis) |
PF08443(RimK)no annotation | 4 | GLU E 49PHE A 54TYR A 156HIS A 159 | None | 1.29A | 4a97J-5k2mE:undetectable | 4a97J-5k2mE:9.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5kzm | TRYPTOPHAN SYNTHASEALPHA CHAINTRYPTOPHAN SYNTHASEBETA CHAIN (Francisellatularensis) |
PF00290(Trp_syntA)PF00291(PALP) | 4 | GLU A 139GLU A 136TYR B 7HIS B 314 | None | 1.39A | 4a97J-5kzmA:undetectable | 4a97J-5kzmA:23.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mqs | BETA-L-ARABINOBIOSIDASE (Bacteroidesthetaiotaomicron) |
PF13088(BNR_2) | 4 | GLU A 638PHE A 634TYR A1016HIS A 683 | None | 1.41A | 4a97J-5mqsA:undetectable | 4a97J-5mqsA:14.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5opq | 3,6-ANHYDRO-D-GALACTOSIDASE (Zobelliagalactanivorans) |
no annotation | 4 | GLU A 521PHE A 317TYR A 307HIS A 293 | None | 1.32A | 4a97J-5opqA:undetectable | 4a97J-5opqA:14.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5t1p | ABC TRANSPORTER,PERIPLASMICSUBSTRATE-BINDINGPROTEIN (Campylobacterjejuni) |
PF13343(SBP_bac_6) | 4 | GLU A 276PHE A 277TYR A 112HIS A 299 | None | 1.13A | 4a97J-5t1pA:undetectable | 4a97J-5t1pA:20.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5tz8 | GLYCOSYL TRANSFERASE (Staphylococcusaureus) |
PF00535(Glycos_transf_2) | 4 | GLU A 443GLU A 434PHE A 432TYR A 399 | None | 1.03A | 4a97J-5tz8A:undetectable | 4a97J-5tz8A:20.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5u02 | GLYCOSYL TRANSFERASE (Staphylococcusaureus) |
no annotation | 4 | GLU A 443GLU A 434PHE A 432TYR A 399 | None | 1.07A | 4a97J-5u02A:undetectable | 4a97J-5u02A:24.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vil | MITOGEN-ACTIVATEDPROTEIN KINASEKINASE KINASE 5 (Homo sapiens) |
no annotation | 4 | GLU A 746GLU A 710PHE A 744TYR A 675 | None | 1.43A | 4a97J-5vilA:undetectable | 4a97J-5vilA:13.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xea | ENVELOPEGLYCOPROTEIN (Thogotothogotovirus) |
PF03273(Baculo_gp64) | 4 | GLU A 57PHE A 212TYR A 259HIS A 257 | None | 1.47A | 4a97J-5xeaA:undetectable | 4a97J-5xeaA:20.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xzb | CYCLIC GMP-AMPSYNTHASE (Mus musculus) |
PF03281(Mab-21) | 4 | GLU A 202GLU A 371TYR A 421HIS A 422 | NoneNoneA9Y A 602 (-4.0A)A9Y A 602 ( 4.5A) | 1.45A | 4a97J-5xzbA:undetectable | 4a97J-5xzbA:19.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6bq1 | PHOSPHATIDYLINOSITOL4-KINASE III ALPHA(PI4KA) (Homo sapiens) |
no annotation | 4 | GLU A1376PHE A1383TYR A1485HIS A1482 | None | 1.49A | 4a97J-6bq1A:undetectable | 4a97J-6bq1A:0.00 |