SIMILAR PATTERNS OF AMINO ACIDS FOR 4A97_I_ZPCI1318_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bf6 PHOSPHOTRIESTERASE
HOMOLOGY PROTEIN

(Escherichia
coli) 		PF02126
(PTE) 		4 GLU A 108
ILE A 113
HIS A  12
VAL A 182
 None
None
ZN  A   1 (-3.5A)
None
 1.17A 4a97I-1bf6A:
undetectable		 4a97I-1bf6A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bg4 ENDO-1,4-BETA-XYLANA
SE

(Penicillium
simplicissimum) 		PF00331
(Glyco_hydro_10) 		4 GLU A  56
PHE A  62
HIS A  84
VAL A  71
 None
None
GOL  A 629 ( 3.8A)
None
 1.04A 4a97I-1bg4A:
undetectable		 4a97I-1bg4A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cdz PROTEIN (DNA-REPAIR
PROTEIN XRCC1)

(Homo sapiens) 		PF16589
(BRCT_2) 		4 GLU A  21
PHE A  17
HIS A  87
VAL A  44
 None
 1.21A 4a97I-1cdzA:
undetectable		 4a97I-1cdzA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ecg GLUTAMINE
PHOSPHORIBOSYLPYROPH
OSPHATE
AMIDOTRANSFERASE

(Escherichia
coli) 		PF00156
(Pribosyltran)
PF13522
(GATase_6) 		4 ILE A 407
PHE A 461
TYR A 258
VAL A 365
 None
None
PIN  A 506 ( 4.0A)
None
 1.24A 4a97I-1ecgA:
0.0		 4a97I-1ecgA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gom ENDO-1,4-BETA-XYLANA
SE

(Thermoascus
aurantiacus) 		PF00331
(Glyco_hydro_10) 		4 GLU A  55
PHE A  61
HIS A  83
VAL A  70
 None
 1.09A 4a97I-1gomA:
undetectable		 4a97I-1gomA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ikp EXOTOXIN A

(Pseudomonas
aeruginosa) 		PF09009
(Exotox-A_cataly)
PF09101
(Exotox-A_bind)
PF09102
(Exotox-A_target) 		4 GLU A 591
ILE A 594
TYR A 502
VAL A 455
 None
 1.06A 4a97I-1ikpA:
0.0		 4a97I-1ikpA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n81 PLASMODIUM
FALCIPARUM GAMETE
ANTIGEN 27/25

(Plasmodium
falciparum) 		PF09216
(Pfg27) 		4 GLU A  42
ILE A 101
PHE A  43
VAL A 172
 None
 1.21A 4a97I-1n81A:
3.1		 4a97I-1n81A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p15 PROTEIN-TYROSINE
PHOSPHATASE ALPHA

(Mus musculus) 		PF00102
(Y_phosphatase) 		4 ILE A 650
PHE A 609
HIS A 718
VAL A 708
 None
 1.24A 4a97I-1p15A:
0.0		 4a97I-1p15A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rqb TRANSCARBOXYLASE 5S
SUBUNIT

(Propionibacterium
freudenreichii) 		PF00682
(HMGL-like)
PF02436
(PYC_OADA) 		4 GLU A 255
ILE A 242
HIS A 217
VAL A 298
 None
None
CO  A 529 (-3.3A)
None
 1.19A 4a97I-1rqbA:
0.0		 4a97I-1rqbA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1su7 CARBON MONOXIDE
DEHYDROGENASE 2

(Carboxydothermus
hydrogenoformans) 		PF03063
(Prismane) 		4 ILE A 190
PHE A 154
HIS A 261
VAL A 264
 None
None
NFS  A 639 (-3.3A)
None
 1.09A 4a97I-1su7A:
undetectable		 4a97I-1su7A:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sus CAFFEOYL-COA
O-METHYLTRANSFERASE

(Medicago sativa) 		PF01596
(Methyltransf_3) 		4 GLU A  85
ILE A 107
HIS A  43
VAL A  38
 SAH  A 301 (-4.1A)
None
None
None
 0.98A 4a97I-1susA:
undetectable		 4a97I-1susA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sy7 CATALASE 1

(Neurospora
crassa) 		PF00199
(Catalase)
PF01965
(DJ-1_PfpI)
PF06628
(Catalase-rel) 		4 ILE A 396
PHE A 355
TYR A 154
VAL A 116
 None
HEM  A1883 ( 4.4A)
None
None
 1.16A 4a97I-1sy7A:
undetectable		 4a97I-1sy7A:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tnu GERANYLGERANYL
TRANSFERASE TYPE I
BETA SUBUNIT

(Rattus
norvegicus) 		PF00432
(Prenyltrans) 		4 GLU B 334
ILE B 337
HIS B 321
VAL B 268
 None
None
ZN  B 378 (-3.4A)
None
 1.24A 4a97I-1tnuB:
undetectable		 4a97I-1tnuB:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u2v ACTIN-RELATED
PROTEIN 3

(Bos taurus) 		PF00022
(Actin) 		4 ILE A 281
PHE A 283
HIS A 176
VAL A 303
 None
 1.21A 4a97I-1u2vA:
undetectable		 4a97I-1u2vA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v4g GLUTAMATE--CYSTEINE
LIGASE

(Escherichia
coli) 		PF04262
(Glu_cys_ligase) 		4 ILE A  57
PHE A  82
HIS A 150
VAL A 347
 None
 1.19A 4a97I-1v4gA:
undetectable		 4a97I-1v4gA:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x1q TRYPTOPHAN SYNTHASE
BETA CHAIN

(Thermus
thermophilus) 		PF00291
(PALP) 		4 GLU A 336
ILE A 260
PHE A  30
VAL A  38
 None
CL  A1001 (-4.0A)
None
None
 1.06A 4a97I-1x1qA:
undetectable		 4a97I-1x1qA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y63 LMAJ004144AAA
PROTEIN

(Leishmania
major) 		PF13238
(AAA_18) 		4 GLU A  69
ILE A  64
TYR A  90
VAL A 104
 None
None
MN  A 356 ( 4.7A)
None
 1.00A 4a97I-1y63A:
undetectable		 4a97I-1y63A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y7n AMYLOID BETA A4
PRECURSOR
PROTEIN-BINDING
FAMILY A MEMBER 1

(Homo sapiens) 		PF00595
(PDZ) 		4 ILE A  43
PHE A  28
HIS A  83
VAL A  12
 None
 1.19A 4a97I-1y7nA:
undetectable		 4a97I-1y7nA:
13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2czr TBP-INTERACTING
PROTEIN

(Thermococcus
kodakarensis) 		PF15517
(TBPIP_N) 		4 GLU A 151
ILE A 170
TYR A 147
HIS A 179
 None
 1.11A 4a97I-2czrA:
undetectable		 4a97I-2czrA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e3z BETA-GLUCOSIDASE

(Phanerochaete
chrysosporium) 		PF00232
(Glyco_hydro_1) 		4 GLU A  22
ILE A  21
TYR A  76
VAL A 111
 None
 1.06A 4a97I-2e3zA:
undetectable		 4a97I-2e3zA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ee6 FILAMIN-B

(Homo sapiens) 		PF00630
(Filamin) 		4 ILE A  56
PHE A  58
HIS A  88
VAL A  14
 None
 1.19A 4a97I-2ee6A:
undetectable		 4a97I-2ee6A:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gz3 ASPARTATE
BETA-SEMIALDEHYDE
DEHYDROGENASE

(Streptococcus
pneumoniae) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		4 GLU A 282
ILE A 289
PHE A 303
VAL A 248
 None
 1.24A 4a97I-2gz3A:
undetectable		 4a97I-2gz3A:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hpw GREEN FLUORESCENT
PROTEIN

(Clytia gregaria) 		PF01353
(GFP) 		4 GLU A 224
ILE A  45
TYR A  49
VAL A  58
 GYS  A  68 ( 3.4A)
GYS  A  68 ( 4.3A)
None
None
 1.12A 4a97I-2hpwA:
undetectable		 4a97I-2hpwA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ihy ABC TRANSPORTER,
ATP-BINDING PROTEIN

(Staphylococcus
aureus) 		PF00005
(ABC_tran) 		4 GLU A  95
PHE A  91
HIS A 124
VAL A 130
 None
 1.09A 4a97I-2ihyA:
undetectable		 4a97I-2ihyA:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iik 3-KETOACYL-COA
THIOLASE,
PEROXISOMAL

(Homo sapiens) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		4 GLU A 223
ILE A 389
PHE A 220
HIS A 378
 None
 1.16A 4a97I-2iikA:
undetectable		 4a97I-2iikA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ixd LMBE-RELATED PROTEIN

(Bacillus cereus) 		PF02585
(PIG-L) 		4 PHE A 217
TYR A  27
HIS A   5
VAL A  66
 None
 1.24A 4a97I-2ixdA:
undetectable		 4a97I-2ixdA:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j4x MITOGEN

(Streptococcus
dysgalactiae) 		PF02876
(Stap_Strp_tox_C) 		4 GLU A 191
PHE A 136
TYR A 171
HIS A 170
 None
None
None
ZN  A1211 (-3.1A)
 1.22A 4a97I-2j4xA:
undetectable		 4a97I-2j4xA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l8o UNCHARACTERIZED
PROTEIN

(Cytophaga
hutchinsonii) 		PF08327
(AHSA1) 		4 GLU A 105
ILE A  92
HIS A  26
VAL A  39
 None
 1.15A 4a97I-2l8oA:
undetectable		 4a97I-2l8oA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nux 2-KETO-3-DEOXYGLUCON
ATE/2-KETO-3-DEOXY-6
-PHOSPHO GLUCONATE
ALDOLASE

(Sulfolobus
acidocaldarius) 		PF00701
(DHDPS) 		4 GLU A   2
ILE A   4
TYR A 127
HIS A 124
 None
 1.18A 4a97I-2nuxA:
undetectable		 4a97I-2nuxA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o04 PECTATE LYASE

(Bacillus
subtilis) 		PF00544
(Pec_lyase_C) 		4 ILE A 196
TYR A 242
HIS A 243
VAL A 277
 None
 0.98A 4a97I-2o04A:
undetectable		 4a97I-2o04A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2odf HYPOTHETICAL PROTEIN
ATU2144

(Agrobacterium
fabrum) 		PF05013
(FGase) 		4 ILE A  38
PHE A   8
HIS A  33
VAL A  78
 None
 1.21A 4a97I-2odfA:
undetectable		 4a97I-2odfA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2owo DNA LIGASE

(Escherichia
coli) 		PF01653
(DNA_ligase_aden)
PF03119
(DNA_ligase_ZBD)
PF03120
(DNA_ligase_OB)
PF12826
(HHH_2)
PF14520
(HHH_5) 		4 ILE A 573
PHE A 508
HIS A 561
VAL A 552
 None
 0.92A 4a97I-2owoA:
2.5		 4a97I-2owoA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qf7 PYRUVATE CARBOXYLASE
PROTEIN

(Rhizobium etli) 		PF00289
(Biotin_carb_N)
PF00364
(Biotin_lipoyl)
PF00682
(HMGL-like)
PF02436
(PYC_OADA)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 ILE A 270
TYR A 284
HIS A 216
VAL A 211
 None
None
AGS  A1162 (-3.9A)
AGS  A1162 ( 4.6A)
 1.23A 4a97I-2qf7A:
undetectable		 4a97I-2qf7A:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v26 MYOSIN VI

(Sus scrofa) 		PF00063
(Myosin_head) 		4 GLU A 478
ILE A 515
PHE A 582
VAL A 697
 None
 1.15A 4a97I-2v26A:
2.5		 4a97I-2v26A:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w82 ORF18

(Enterococcus
faecalis) 		PF07275
(ArdA) 		4 GLU A 162
ILE A 105
PHE A 153
TYR A 119
 None
 1.20A 4a97I-2w82A:
undetectable		 4a97I-2w82A:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wdu GLUTATHIONE
TRANSFERASE SIGMA
CLASS

(Fasciola
hepatica) 		PF14497
(GST_C_3) 		4 GLU A 101
ILE A  98
HIS A 169
VAL A 174
 None
None
BR  A1218 (-3.7A)
None
 1.21A 4a97I-2wduA:
4.6		 4a97I-2wduA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x2i ALPHA-1,4-GLUCAN
LYASE ISOZYME 1

(Gracilariopsis
lemaneiformis) 		PF01055
(Glyco_hydro_31) 		4 ILE A 147
TYR A  89
HIS A 325
VAL A 337
 None
None
None
CSO  A 336 ( 3.4A)
 0.99A 4a97I-2x2iA:
undetectable		 4a97I-2x2iA:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yn9 POTASSIUM-TRANSPORTI
NG ATPASE ALPHA
CHAIN 1

(Sus scrofa) 		PF00122
(E1-E2_ATPase)
PF00689
(Cation_ATPase_C)
PF00690
(Cation_ATPase_N)
PF09040
(H-K_ATPase_N)
PF13246
(Cation_ATPase) 		4 ILE A 816
PHE A 931
TYR A 799
VAL A 805
 None
 0.92A 4a97I-2yn9A:
2.8		 4a97I-2yn9A:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yyz SUGAR ABC
TRANSPORTER,
ATP-BINDING PROTEIN

(Thermotoga
maritima) 		PF00005
(ABC_tran)
PF08402
(TOBE_2) 		4 GLU A 320
ILE A 322
HIS A 348
VAL A 271
 None
 1.20A 4a97I-2yyzA:
undetectable		 4a97I-2yyzA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b78 EXOTOXIN A

(Pseudomonas
aeruginosa) 		PF09009
(Exotox-A_cataly) 		4 GLU B 591
ILE B 594
TYR B 502
VAL B 455
 None
None
None
NAD  B 700 ( 3.6A)
 1.14A 4a97I-3b78B:
undetectable		 4a97I-3b78B:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dul O-METHYLTRANSFERASE,
PUTATIVE

(Bacillus cereus) 		PF01596
(Methyltransf_3) 		4 ILE A  65
PHE A 138
HIS A  95
VAL A  28
 None
 1.18A 4a97I-3dulA:
undetectable		 4a97I-3dulA:
25.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dwl ACTIN-RELATED
PROTEIN 3

(Schizosaccharomyces
pombe) 		PF00022
(Actin) 		4 ILE A 292
PHE A 294
HIS A 192
VAL A 314
 None
 1.08A 4a97I-3dwlA:
undetectable		 4a97I-3dwlA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iz3 STRUCTURAL PROTEIN
VP1

(Cypovirus 1) 		no annotation 4 ILE B 766
PHE B 691
TYR B 772
HIS B 701
 None
 0.87A 4a97I-3iz3B:
2.5		 4a97I-3iz3B:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k55 BETA-HEMOLYSIN

(Staphylococcus
aureus) 		PF03372
(Exo_endo_phos) 		4 ILE A 183
TYR A 134
HIS A 116
VAL A 102
 None
 1.00A 4a97I-3k55A:
undetectable		 4a97I-3k55A:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k85 D-GLYCERO-D-MANNO-HE
PTOSE 1-PHOSPHATE
KINASE

(Bacteroides
thetaiotaomicron) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		4 ILE A 180
PHE A 173
TYR A 137
VAL A 120
 None
 1.22A 4a97I-3k85A:
undetectable		 4a97I-3k85A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nrd HISTIDINE TRIAD
(HIT) PROTEIN

(Sinorhizobium
meliloti) 		PF01230
(HIT) 		4 GLU A  50
ILE A  45
PHE A  49
HIS A  94
 None
None
None
SO4  A 207 (-3.9A)
 1.20A 4a97I-3nrdA:
undetectable		 4a97I-3nrdA:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ohw PHYCOBILISOME LCM
CORE-MEMBRANE LINKER
POLYPEPTIDE

(Synechocystis
sp. PCC 6803) 		no annotation 4 GLU B 764
ILE B 756
HIS B 807
VAL B 839
 None
 1.20A 4a97I-3ohwB:
undetectable		 4a97I-3ohwB:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p8c NCK-ASSOCIATED
PROTEIN 1

(Homo sapiens) 		PF09735
(Nckap1) 		4 ILE B 733
PHE B 825
HIS B 858
VAL B 912
 None
 1.15A 4a97I-3p8cB:
0.1		 4a97I-3p8cB:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p8c NCK-ASSOCIATED
PROTEIN 1

(Homo sapiens) 		PF09735
(Nckap1) 		4 ILE B 733
PHE B 825
TYR B 792
VAL B 912
 None
 1.21A 4a97I-3p8cB:
0.1		 4a97I-3p8cB:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pm6 PUTATIVE
FRUCTOSE-BISPHOSPHAT
E ALDOLASE

(Coccidioides
immitis) 		PF01116
(F_bP_aldolase) 		4 ILE A 289
PHE A 228
HIS A  84
VAL A 157
 None
 1.22A 4a97I-3pm6A:
undetectable		 4a97I-3pm6A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rko NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT M
NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT N

(Escherichia
coli) 		no annotation 4 GLU M 108
ILE M 109
HIS N 435
VAL N 430
 None
 1.15A 4a97I-3rkoM:
4.0		 4a97I-3rkoM:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sqw ATP-DEPENDENT RNA
HELICASE MSS116,
MITOCHONDRIAL

(Saccharomyces
cerevisiae) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		4 GLU A 484
ILE A 480
PHE A 352
VAL A 515
 None
 1.17A 4a97I-3sqwA:
undetectable		 4a97I-3sqwA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sun DNA POLYMERASE

(Escherichia
virus RB69) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		4 GLU A 297
ILE A 334
PHE A 296
VAL A 782
 None
 1.19A 4a97I-3sunA:
3.4		 4a97I-3sunA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tgh GLIDEOSOME-ASSOCIATE
D PROTEIN 50

(Plasmodium
falciparum) 		PF00149
(Metallophos) 		4 PHE A  29
TYR A 153
HIS A 152
VAL A 102
 None
 0.98A 4a97I-3tghA:
undetectable		 4a97I-3tghA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4anj UNCONVENTIONAL
MYOSIN-VI, GREEN
FLUORESCENT PROTEIN

(Aequorea
victoria;
Sus scrofa) 		PF00063
(Myosin_head)
PF01353
(GFP) 		4 GLU A 478
ILE A 515
PHE A 582
VAL A 697
 None
 1.20A 4a97I-4anjA:
2.4		 4a97I-4anjA:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4btf MIXED LINEAGE KINASE
DOMAIN-LIKE PROTEIN

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		4 GLU A 338
ILE A 254
PHE A 337
VAL A 388
 None
 1.05A 4a97I-4btfA:
3.7		 4a97I-4btfA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4db4 ATP-DEPENDENT RNA
HELICASE MSS116,
MITOCHONDRIAL

(Saccharomyces
cerevisiae) 		PF00271
(Helicase_C) 		4 GLU A 484
ILE A 480
PHE A 352
VAL A 515
 None
 1.21A 4a97I-4db4A:
undetectable		 4a97I-4db4A:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4di5 5-EPI-ARISTOLOCHENE
SYNTHASE

(Nicotiana
tabacum) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		4 GLU A 280
PHE A 279
HIS A 199
VAL A 518
 None
 1.23A 4a97I-4di5A:
3.8		 4a97I-4di5A:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dmo N-HYDROXYARYLAMINE
O-ACETYLTRANSFERASE

(Bacillus cereus) 		PF00797
(Acetyltransf_2) 		4 ILE A  43
TYR A  70
HIS A 108
VAL A 191
 None
 1.03A 4a97I-4dmoA:
undetectable		 4a97I-4dmoA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4em6 GLUCOSE-6-PHOSPHATE
ISOMERASE

(Brucella
melitensis) 		no annotation 4 GLU D 400
ILE D 333
HIS D 490
VAL D  74
 None
 1.17A 4a97I-4em6D:
2.2		 4a97I-4em6D:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f4c MULTIDRUG RESISTANCE
PROTEIN PGP-1

(Caenorhabditis
elegans) 		PF00005
(ABC_tran)
PF00664
(ABC_membrane) 		4 ILE A 106
PHE A 778
HIS A 234
VAL A 362
 None
 1.04A 4a97I-4f4cA:
undetectable		 4a97I-4f4cA:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f7k LACCASE

(uncultured
bacterium) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 ILE A 297
PHE A 244
HIS A 153
VAL A 194
 None
 0.85A 4a97I-4f7kA:
undetectable		 4a97I-4f7kA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ghk GAMMA-GLUTAMYL
PHOSPHATE REDUCTASE

(Burkholderia
thailandensis) 		PF00171
(Aldedh) 		4 ILE A 392
PHE A 384
HIS A 231
VAL A 246
 None
 1.21A 4a97I-4ghkA:
undetectable		 4a97I-4ghkA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4glx DNA LIGASE

(Escherichia
coli) 		PF01653
(DNA_ligase_aden)
PF03119
(DNA_ligase_ZBD)
PF03120
(DNA_ligase_OB)
PF12826
(HHH_2)
PF14520
(HHH_5) 		4 ILE A 573
PHE A 508
HIS A 561
VAL A 552
 None
 0.98A 4a97I-4glxA:
2.7		 4a97I-4glxA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nzr PGT135 HEAVY CHAIN
PROTEIN M TD

(Homo sapiens;
Mycoplasma
genitalium) 		PF07654
(C1-set)
PF07686
(V-set)
no annotation 		4 GLU M 427
ILE M 449
TYR H  32
HIS H  95
 None
 0.80A 4a97I-4nzrM:
undetectable		 4a97I-4nzrM:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ph9 PROSTAGLANDIN G/H
SYNTHASE 2

(Mus musculus) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		4 ILE A 565
PHE A 199
TYR A 302
HIS A 233
 None
 1.23A 4a97I-4ph9A:
undetectable		 4a97I-4ph9A:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pxl CYTOSOLIC ALDEHYDE
DEHYDROGENASE RF2C

(Zea mays) 		PF00171
(Aldedh) 		4 ILE A 123
TYR A 205
HIS A 207
VAL A 214
 None
 1.23A 4a97I-4pxlA:
undetectable		 4a97I-4pxlA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qiw DNA-DIRECTED RNA
POLYMERASE

(Thermococcus
kodakarensis) 		PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4) 		4 ILE A 637
TYR A 626
HIS A 507
VAL A 660
 None
 1.23A 4a97I-4qiwA:
2.6		 4a97I-4qiwA:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r4g PUTATIVE LIPOPROTEIN
YCDA

(Bacillus
subtilis) 		PF11611
(DUF4352)
PF17118
(DUF5105) 		4 GLU A 354
ILE A 352
TYR A 307
VAL A 284
 None
 1.13A 4a97I-4r4gA:
3.4		 4a97I-4r4gA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r4g PUTATIVE LIPOPROTEIN
YCDA

(Bacillus
subtilis) 		PF11611
(DUF4352)
PF17118
(DUF5105) 		4 GLU A 354
ILE A 352
TYR A 307
VAL A 300
 None
 0.95A 4a97I-4r4gA:
3.4		 4a97I-4r4gA:
21.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4twf CYS-LOOP
LIGAND-GATED ION
CHANNEL

(Dickeya
chrysanthemi) 		PF02931
(Neur_chan_LBD) 		4 GLU A  77
ILE A  79
PHE A 133
TYR A 175
 BR7  A 401 ( 4.9A)
None
BR7  A 401 (-4.5A)
BR7  A 401 (-3.9A)
 0.49A 4a97I-4twfA:
33.9		 4a97I-4twfA:
99.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tz0 ATP-DEPENDENT RNA
HELICASE MSS116,
MITOCHONDRIAL

(Saccharomyces
cerevisiae) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		4 GLU A 484
ILE A 480
PHE A 352
VAL A 515
 None
 1.23A 4a97I-4tz0A:
undetectable		 4a97I-4tz0A:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x0q DNA POLYMERASE THETA

(Homo sapiens) 		PF00476
(DNA_pol_A) 		4 GLU A2049
ILE A2053
HIS A2236
VAL A2232
 None
None
None
GOL  A2602 (-4.5A)
 0.97A 4a97I-4x0qA:
undetectable		 4a97I-4x0qA:
16.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4yeu CYS-LOOP
LIGAND-GATED ION
CHANNEL,PROTON-GATED
ION CHANNEL

(Dickeya
chrysanthemi;
Gloeobacter
violaceus) 		PF02931
(Neur_chan_LBD) 		5 GLU A  77
ILE A  79
PHE A 133
TYR A 175
HIS A 177
 None
 0.75A 4a97I-4yeuA:
29.5		 4a97I-4yeuA:
71.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zv9 UNCHARACTERIZED
PROTEIN

(Escherichia
coli) 		PF01738
(DLH) 		4 GLU A  71
ILE A  73
PHE A  69
TYR A 173
 None
 1.24A 4a97I-4zv9A:
undetectable		 4a97I-4zv9A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eb5 HNL ISOENZYME 5

(Prunus dulcis) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		4 ILE A 127
PHE A 121
TYR A 509
VAL A 141
 None
 1.19A 4a97I-5eb5A:
undetectable		 4a97I-5eb5A:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ehk LANTIBIOTIC
DEHYDRATASE

(Microbispora
corallina) 		PF04738
(Lant_dehydr_N)
PF14028
(Lant_dehydr_C) 		4 GLU A 606
ILE A 607
HIS A 533
VAL A 640
 None
 1.10A 4a97I-5ehkA:
undetectable		 4a97I-5ehkA:
12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fi0 PHOSPHATIDYLINOSITOL
3,4,5-TRISPHOSPHATE-
DEPENDENT RAC
EXCHANGER 1
PROTEIN,PHOSPHATIDYL
INOSITOL
3,4,5-TRISPHOSPHATE-
DEPENDENT RAC
EXCHANGER 1 PROTEIN

(Homo sapiens) 		PF00169
(PH)
PF00621
(RhoGEF) 		4 ILE A 331
PHE A 291
HIS A 349
VAL A 355
 None
 1.07A 4a97I-5fi0A:
3.1		 4a97I-5fi0A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fwm HEAT SHOCK PROTEIN
HSP 90 BETA

(Homo sapiens) 		PF00183
(HSP90)
PF02518
(HATPase_c) 		4 ILE A 441
TYR A 457
HIS A 458
VAL A 494
 None
 1.15A 4a97I-5fwmA:
undetectable		 4a97I-5fwmA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h28 OXYSTEROL-BINDING
PROTEIN HOMOLOG 1

(Saccharomyces
cerevisiae) 		PF13637
(Ank_4) 		4 ILE A  86
PHE A  40
HIS A  57
VAL A  62
 None
 1.08A 4a97I-5h28A:
undetectable		 4a97I-5h28A:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hmp UNCONVENTIONAL
MYOSIN-VC

(Homo sapiens) 		PF00063
(Myosin_head) 		4 GLU A 457
ILE A 494
PHE A 551
HIS A 466
 None
 1.00A 4a97I-5hmpA:
undetectable		 4a97I-5hmpA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i5j NITROUS-OXIDE
REDUCTASE

(Shewanella
denitrificans) 		no annotation 4 ILE A 188
PHE A 274
HIS A 318
VAL A 313
 None
 1.23A 4a97I-5i5jA:
undetectable		 4a97I-5i5jA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ikr PROSTAGLANDIN G/H
SYNTHASE 2

(Homo sapiens) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		4 ILE A 564
PHE A 198
TYR A 301
HIS A 232
 None
 1.22A 4a97I-5ikrA:
undetectable		 4a97I-5ikrA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j6s ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 2

(Homo sapiens) 		PF01433
(Peptidase_M1)
PF11838
(ERAP1_C) 		4 GLU A 410
TYR A 298
HIS A 297
VAL A 284
 None
 1.23A 4a97I-5j6sA:
4.4		 4a97I-5j6sA:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k94 MALTOSE-BINDING
PERIPLASMIC
PROTEIN,PROTEIN
TRANSLOCASE SUBUNIT
SECA,MALTOSE-BINDING
PERIPLASMIC PROTEIN

(Escherichia
coli) 		PF01043
(SecA_PP_bind)
PF01547
(SBP_bac_1)
PF13416
(SBP_bac_8) 		4 GLU A 358
ILE A 365
HIS A 308
VAL A 272
 None
 1.20A 4a97I-5k94A:
undetectable		 4a97I-5k94A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kvp ZOOCIN A
ENDOPEPTIDASE

(Streptococcus
equi) 		PF01551
(Peptidase_M23) 		4 ILE A  93
PHE A  57
HIS A 120
VAL A  35
 None
 1.14A 4a97I-5kvpA:
undetectable		 4a97I-5kvpA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kz5 CYSTEINE
DESULFURASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00266
(Aminotran_5) 		4 GLU 1 416
TYR 1 317
HIS 1 319
VAL 1 310
 None
 0.94A 4a97I-5kz51:
undetectable		 4a97I-5kz51:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l3x NEGATIVE ELONGATION
FACTOR C/D

(Homo sapiens) 		PF04858
(TH1) 		4 PHE B 333
TYR B 356
HIS B 354
VAL B 390
 None
 1.10A 4a97I-5l3xB:
undetectable		 4a97I-5l3xB:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m0k BETA-XYLANASE

(Cellulomonas
flavigena) 		no annotation 4 GLU A  53
PHE A  59
HIS A  81
VAL A  68
 None
 0.99A 4a97I-5m0kA:
undetectable		 4a97I-5m0kA:
12.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mrj BETA-XYLANASE

(Acremonium
chrysogenum) 		no annotation 4 GLU A 145
PHE A 151
HIS A 173
VAL A 160
 None
 1.12A 4a97I-5mrjA:
undetectable		 4a97I-5mrjA:
9.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nny WIPB

(Legionella
pneumophila) 		no annotation 4 ILE A 278
PHE A 246
HIS A 231
VAL A 228
 None
 1.10A 4a97I-5nnyA:
undetectable		 4a97I-5nnyA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5of4 GENERAL
TRANSCRIPTION FACTOR
IIH SUBUNIT 2

(Homo sapiens) 		PF04056
(Ssl1) 		4 ILE E 170
PHE E  91
TYR E 228
HIS E 227
 None
 1.06A 4a97I-5of4E:
undetectable		 4a97I-5of4E:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tch TRYPTOPHAN SYNTHASE
BETA CHAIN

(Mycobacterium
tuberculosis) 		PF00291
(PALP) 		4 GLU B 326
ILE B 252
PHE B  19
VAL B  30
 None
 1.06A 4a97I-5tchB:
undetectable		 4a97I-5tchB:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xd6 PROTEIN KINASE
SUPERFAMILY PROTEIN

(Arabidopsis
thaliana) 		no annotation 4 ILE A 215
PHE A 262
HIS A 150
VAL A 287
 None
 1.22A 4a97I-5xd6A:
undetectable		 4a97I-5xd6A:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xjy ATP-BINDING CASSETTE
SUB-FAMILY A MEMBER
1

(Homo sapiens) 		PF00005
(ABC_tran)
PF12698
(ABC2_membrane_3) 		4 ILE A1677
PHE A1675
HIS A1686
VAL A1693
 None
 1.17A 4a97I-5xjyA:
3.0		 4a97I-5xjyA:
9.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z06 BDI_3064 PROTEIN

(Parabacteroides
distasonis) 		no annotation 4 GLU A 482
PHE A 553
TYR A 517
VAL A 524
 GOL  A 805 ( 2.6A)
GOL  A 805 (-4.4A)
GOL  A 805 (-4.6A)
None
 1.13A 4a97I-5z06A:
2.2		 4a97I-5z06A:
12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c8v COENZYME PQQ
SYNTHESIS PROTEIN E

(Methylobacterium
extorquens) 		no annotation 4 GLU A 272
TYR A 281
HIS A 285
VAL A  56
 None
 1.24A 4a97I-6c8vA:
undetectable		 4a97I-6c8vA:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cfw MBH13 NADH
DEHYDROGENASE
SUBUNIT
MEMBRANE-BOUND
HYDROGENASE SUBUNIT
ALPHA

(Pyrococcus
furiosus) 		no annotation 4 ILE M 287
PHE M 204
TYR L 124
VAL L 366
 None
 1.10A 4a97I-6cfwM:
5.1		 4a97I-6cfwM:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d6v TELOMERASE-ASSOCIATE
D PROTEIN 82

(Tetrahymena
thermophila) 		no annotation 4 GLU D 632
ILE D 631
HIS D 584
VAL D 562
 None
 1.07A 4a97I-6d6vD:
undetectable		 4a97I-6d6vD:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gne -

(-) 		no annotation 4 GLU A 370
PHE A 371
TYR A 347
VAL A 327
 None
 1.05A 4a97I-6gneA:
undetectable		 4a97I-6gneA:
undetectable