SIMILAR PATTERNS OF AMINO ACIDS FOR 4A97_I_ZPCI1318

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1air PECTATE LYASE C

(Dickeya
chrysanthemi) 		PF00544
(Pec_lyase_C) 		4 PHE A 103
VAL A  82
ILE A  33
GLU A  60
 None
 0.93A 4a97H-1airA:
undetectable		 4a97H-1airA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bf6 PHOSPHOTRIESTERASE
HOMOLOGY PROTEIN

(Escherichia
coli) 		PF02126
(PTE) 		4 PHE A   3
VAL A  78
ARG A 153
ILE A 122
 None
 1.05A 4a97H-1bf6A:
undetectable		 4a97H-1bf6A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1byr PROTEIN
(ENDONUCLEASE)

(Salmonella
enterica) 		PF13091
(PLDc_2) 		4 PHE A 110
VAL A  19
ILE A  23
GLU A 122
 None
 1.08A 4a97H-1byrA:
0.0		 4a97H-1byrA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c4k PROTEIN (ORNITHINE
DECARBOXYLASE)

(Lactobacillus
sp. 30A) 		PF01276
(OKR_DC_1)
PF03709
(OKR_DC_1_N)
PF03711
(OKR_DC_1_C) 		4 VAL A 664
ARG A 245
ILE A 251
GLU A 671
 None
 1.11A 4a97H-1c4kA:
0.0		 4a97H-1c4kA:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ce7 PROTEIN
(RIBOSOME-INACTIVATI
NG PROTEIN TYPE II)

(Viscum album) 		PF00161
(RIP) 		4 PHE A 209
VAL A 201
ILE A  37
ASN A  35
 None
 1.14A 4a97H-1ce7A:
0.0		 4a97H-1ce7A:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ciy CRYIA(A)

(Bacillus
thuringiensis) 		PF00555
(Endotoxin_M)
PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N) 		4 PHE A 574
TYR A 522
VAL A 524
ILE A 601
 None
 1.05A 4a97H-1ciyA:
0.0		 4a97H-1ciyA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e5f METHIONINE
GAMMA-LYASE

(Trichomonas
vaginalis) 		PF01053
(Cys_Met_Meta_PP) 		4 PHE A 131
VAL A 129
ILE A 127
GLU A 361
 None
 1.09A 4a97H-1e5fA:
0.0		 4a97H-1e5fA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eth TRIACYLGLYCEROL
ACYL-HYDROLASE

(Sus scrofa) 		PF00151
(Lipase)
PF01477
(PLAT) 		4 PHE A 387
TYR A 341
VAL A 343
ILE A 419
 None
 0.97A 4a97H-1ethA:
0.0		 4a97H-1ethA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f82 BOTULINUM NEUROTOXIN
TYPE B

(Clostridium
botulinum) 		PF01742
(Peptidase_M27) 		4 PHE A 154
VAL A 135
ARG A  27
ILE A 132
 None
 1.08A 4a97H-1f82A:
0.0		 4a97H-1f82A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gpl RP2 LIPASE

(Cavia porcellus) 		PF00151
(Lipase)
PF01477
(PLAT) 		4 PHE A 386
TYR A 340
VAL A 342
ILE A 420
 None
 0.89A 4a97H-1gplA:
undetectable		 4a97H-1gplA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jc9 TECHYLECTIN-5A

(Tachypleus
tridentatus) 		PF00147
(Fibrinogen_C) 		4 TYR A  79
VAL A  78
ILE A  65
GLU A 256
 None
 0.96A 4a97H-1jc9A:
undetectable		 4a97H-1jc9A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kfu M-CALPAIN LARGE
SUBUNIT

(Homo sapiens) 		PF00648
(Peptidase_C2)
PF01067
(Calpain_III)
PF13833
(EF-hand_8) 		4 PHE L 475
VAL L 409
ILE L 499
GLU L 460
 None
 0.75A 4a97H-1kfuL:
0.3		 4a97H-1kfuL:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lpb LIPASE

(Homo sapiens) 		PF00151
(Lipase)
PF01477
(PLAT) 		4 PHE B 386
TYR B 340
VAL B 342
ILE B 420
 None
 0.85A 4a97H-1lpbB:
undetectable		 4a97H-1lpbB:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nbq JUNCTIONAL ADHESION
MOLECULE 1

(Homo sapiens) 		PF07686
(V-set)
PF13927
(Ig_3) 		4 PHE A  55
TYR A  52
VAL A  31
GLU A 113
 None
 1.14A 4a97H-1nbqA:
undetectable		 4a97H-1nbqA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nf2 PHOSPHATASE

(Thermotoga
maritima) 		PF08282
(Hydrolase_3) 		4 TYR A  36
VAL A  38
ILE A  63
GLU A 208
 None
 1.01A 4a97H-1nf2A:
undetectable		 4a97H-1nf2A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q9p HIV-1 PROTEASE

(Homo sapiens) 		PF00077
(RVP) 		4 TYR A  59
VAL A  75
ILE A  64
GLU A  35
 None
 1.09A 4a97H-1q9pA:
undetectable		 4a97H-1q9pA:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rrh SEED LIPOXYGENASE-3

(Glycine max) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		4 PHE A  53
VAL A  58
ILE A 117
ASN A 119
 None
 1.14A 4a97H-1rrhA:
undetectable		 4a97H-1rrhA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wu8 HYPOTHETICAL PROTEIN
PH0463

(Pyrococcus
horikoshii) 		PF01887
(SAM_adeno_trans) 		4 TYR A  85
VAL A  87
ILE A 109
GLU A 140
 None
 1.11A 4a97H-1wu8A:
undetectable		 4a97H-1wu8A:
24.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wxx HYPOTHETICAL PROTEIN
TTHA1280

(Thermus
thermophilus) 		PF10672
(Methyltrans_SAM) 		5 PHE A 335
TYR A 304
VAL A 339
ILE A 312
ASN A 308
 None
 1.39A 4a97H-1wxxA:
undetectable		 4a97H-1wxxA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xew SMC PROTEIN

(Pyrococcus
furiosus) 		PF02463
(SMC_N) 		4 PHE X  12
TYR X  15
VAL X  82
ILE X  84
 None
 0.97A 4a97H-1xewX:
undetectable		 4a97H-1xewX:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xmx HYPOTHETICAL PROTEIN
VC1899

(Vibrio cholerae) 		PF09002
(DUF1887) 		4 PHE A 106
TYR A 109
VAL A  87
ILE A   3
 None
 0.96A 4a97H-1xmxA:
undetectable		 4a97H-1xmxA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yf8 BETA-GALACTOSIDE-SPE
CIFIC LECTIN 4

(Viscum album) 		PF00161
(RIP) 		4 PHE A 208
VAL A 200
ILE A  37
ASN A  35
 None
 1.10A 4a97H-1yf8A:
undetectable		 4a97H-1yf8A:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eaa 7S GLOBULIN-3

(Vigna angularis) 		PF00190
(Cupin_1) 		4 PHE A  47
TYR A  60
VAL A  62
ILE A 134
 None
 0.86A 4a97H-2eaaA:
undetectable		 4a97H-2eaaA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eo4 150AA LONG
HYPOTHETICAL
HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN

(Sulfurisphaera
tokodaii) 		PF01230
(HIT) 		4 PHE A 111
TYR A 107
VAL A  73
ILE A  69
 None
 1.05A 4a97H-2eo4A:
undetectable		 4a97H-2eo4A:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f6h MYOSIN-2

(Saccharomyces
cerevisiae) 		PF01843
(DIL) 		4 PHE X 168
TYR X 129
VAL X 125
ILE X 175
 None
 1.07A 4a97H-2f6hX:
undetectable		 4a97H-2f6hX:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fk7 METHOXY MYCOLIC ACID
SYNTHASE 4

(Mycobacterium
tuberculosis) 		PF02353
(CMAS) 		4 TYR A  59
VAL A  62
ILE A 145
GLU A  93
 None
 0.95A 4a97H-2fk7A:
undetectable		 4a97H-2fk7A:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gks BIFUNCTIONAL SAT/APS
KINASE

(Aquifex
aeolicus) 		PF01583
(APS_kinase)
PF01747
(ATP-sulfurylase)
PF14306
(PUA_2) 		4 PHE A 471
VAL A 462
ILE A 430
GLU A 517
 None
 1.12A 4a97H-2gksA:
undetectable		 4a97H-2gksA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hnk SAM-DEPENDENT
O-METHYLTRANSFERASE

(Leptospira
interrogans) 		PF01596
(Methyltransf_3) 		4 PHE A 152
VAL A 225
ILE A 221
GLU A  66
 None
None
None
SAH  A2001 ( 4.2A)
 1.13A 4a97H-2hnkA:
undetectable		 4a97H-2hnkA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ija ARYLAMINE
N-ACETYLTRANSFERASE
1

(Homo sapiens) 		PF00797
(Acetyltransf_2) 		4 TYR A  94
VAL A  93
ILE A 106
GLU A 182
 UNX  A 502 (-4.3A)
None
None
None
 1.08A 4a97H-2ijaA:
undetectable		 4a97H-2ijaA:
24.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qn0 NEUROTOXIN

(Clostridium
botulinum) 		PF01742
(Peptidase_M27) 		4 TYR A 202
VAL A 379
ILE A 256
GLU A 360
 None
 0.97A 4a97H-2qn0A:
undetectable		 4a97H-2qn0A:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uut RNA-DIRECTED RNA
POLYMERASE

(Sapporo virus) 		PF00680
(RdRP_1) 		4 PHE A 337
TYR A  90
VAL A  87
ILE A 261
 None
 1.11A 4a97H-2uutA:
undetectable		 4a97H-2uutA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v8p 4-DIPHOSPHOCYTIDYL-2
-C-METHYL-D-ERYTHRIT
OL KINASE

(Aquifex
aeolicus) 		PF00288
(GHMP_kinases_N) 		4 TYR A  63
VAL A  62
ILE A  83
GLU A  70
 None
 1.04A 4a97H-2v8pA:
undetectable		 4a97H-2v8pA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yjg LACTATE RACEMASE
APOPROTEIN

(Thermoanaerobacterium
thermosaccharolyticum) 		PF09861
(DUF2088) 		4 TYR A 381
VAL A 384
ILE A 293
GLU A 397
 None
 1.04A 4a97H-2yjgA:
undetectable		 4a97H-2yjgA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zsg AMINOPEPTIDASE P,
PUTATIVE

(Thermotoga
maritima) 		PF00557
(Peptidase_M24)
PF01321
(Creatinase_N) 		4 PHE A  38
ILE A  24
ASN A  23
GLU A  67
 None
 1.10A 4a97H-2zsgA:
undetectable		 4a97H-2zsgA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ahi XYLULOSE
5-PHOSPHATE/FRUCTOSE
6-PHOSPHATE
PHOSPHOKETOLASE

(Bifidobacterium
breve) 		PF03894
(XFP)
PF09363
(XFP_C)
PF09364
(XFP_N) 		4 PHE A 504
TYR A 501
ASN A 549
GLU A 479
 None
 1.12A 4a97H-3ahiA:
undetectable		 4a97H-3ahiA:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bm3 PSPGI RESTRICTION
ENDONUCLEASE

(Pyrococcus sp.
GI-H) 		PF09019
(EcoRII-C) 		4 PHE A 104
VAL A 159
ILE A 157
GLU A  60
 None
 0.83A 4a97H-3bm3A:
1.3		 4a97H-3bm3A:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eei 5-METHYLTHIOADENOSIN
E
NUCLEOSIDASE/S-ADENO
SYLHOMOCYSTEINE
NUCLEOSIDASE

(Neisseria
meningitidis) 		PF01048
(PNP_UDP_1) 		4 VAL A 172
ARG A 166
ILE A 165
GLU A 145
 None
 1.05A 4a97H-3eeiA:
undetectable		 4a97H-3eeiA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ejg NON-STRUCTURAL
PROTEIN 3

(Human
coronavirus
229E) 		PF01661
(Macro) 		4 PHE A   6
TYR A  15
VAL A 150
ILE A 120
 None
 0.96A 4a97H-3ejgA:
undetectable		 4a97H-3ejgA:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ewr NON-STRUCTURAL
PROTEIN 3

(Human
coronavirus
229E) 		PF01661
(Macro) 		4 PHE A   7
TYR A  16
VAL A 151
ILE A 121
 None
None
APR  A 169 ( 4.6A)
None
 0.93A 4a97H-3ewrA:
undetectable		 4a97H-3ewrA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ffh HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE

(Listeria
innocua) 		PF00155
(Aminotran_1_2) 		4 TYR A 233
VAL A  90
ILE A  94
GLU A 195
 None
SO4  A 361 (-3.5A)
None
None
 1.13A 4a97H-3ffhA:
undetectable		 4a97H-3ffhA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ihp UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 5

(Homo sapiens) 		PF00443
(UCH)
PF00627
(UBA)
PF02148
(zf-UBP) 		4 PHE A 461
TYR A 568
VAL A 570
ILE A 827
 None
 1.09A 4a97H-3ihpA:
undetectable		 4a97H-3ihpA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jb9 PRE-MRNA-SPLICING
FACTOR CWF4

(Schizosaccharomyces
pombe) 		PF02184
(HAT) 		4 TYR R 194
VAL R 198
ASN R 206
GLU R 214
 None
 1.11A 4a97H-3jb9R:
undetectable		 4a97H-3jb9R:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k2n SIGMA-54-DEPENDENT
TRANSCRIPTIONAL
REGULATOR

(Chlorobaculum
tepidum) 		PF13185
(GAF_2) 		4 PHE A  59
VAL A 135
ILE A 117
GLU A  60
 None
 1.10A 4a97H-3k2nA:
undetectable		 4a97H-3k2nA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kq0 ALPHA-1-ACID
GLYCOPROTEIN 1

(Homo sapiens) 		PF00061
(Lipocalin) 		4 PHE A  32
TYR A  37
VAL A  41
ILE A  44
 None
 1.06A 4a97H-3kq0A:
undetectable		 4a97H-3kq0A:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ltf PROTEIN SPITZ

(Drosophila
melanogaster) 		no annotation 4 PHE D  23
VAL D  25
ILE D  27
GLU D  36
 None
 0.89A 4a97H-3ltfD:
undetectable		 4a97H-3ltfD:
10.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3muq UNCHARACTERIZED
CONSERVED PROTEIN

(Vibrio
parahaemolyticus) 		PF12849
(PBP_like_2) 		4 PHE A  91
TYR A  96
VAL A 225
ILE A 233
 None
 1.13A 4a97H-3muqA:
undetectable		 4a97H-3muqA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nua PHOSPHORIBOSYLAMINOI
MIDAZOLE-SUCCINOCARB
OXAMIDE SYNTHASE

(Clostridium
perfringens) 		PF01259
(SAICAR_synt) 		4 TYR A 226
VAL A 229
ILE A 172
GLU A 193
 None
 1.14A 4a97H-3nuaA:
undetectable		 4a97H-3nuaA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pco PHENYLALANYL-TRNA
SYNTHETASE, BETA
CHAIN

(Escherichia
coli) 		PF01588
(tRNA_bind)
PF03147
(FDX-ACB)
PF03483
(B3_4)
PF03484
(B5) 		4 VAL B 250
ILE B 246
ASN B 254
GLU B 334
 None
 1.01A 4a97H-3pcoB:
undetectable		 4a97H-3pcoB:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pm0 CYTOCHROME P450 1B1

(Homo sapiens) 		PF00067
(p450) 		4 TYR A 214
VAL A 199
ARG A 213
ASN A 203
 None
 1.12A 4a97H-3pm0A:
undetectable		 4a97H-3pm0A:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r0h INACTIVATION-NO-AFTE
R-POTENTIAL D
PROTEIN

(Drosophila
melanogaster) 		PF00595
(PDZ) 		4 PHE A 583
VAL A 585
ILE A 619
GLU A 581
 None
 1.09A 4a97H-3r0hA:
undetectable		 4a97H-3r0hA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u7s POL POLYPROTEIN

(Human
immunodeficiency
virus 1) 		PF00077
(RVP) 		4 TYR A  59
VAL A  75
ILE A  64
GLU A  35
 None
 1.09A 4a97H-3u7sA:
undetectable		 4a97H-3u7sA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u95 GLYCOSIDE HYDROLASE,
FAMILY 4

(Thermotoga
neapolitana) 		PF02056
(Glyco_hydro_4)
PF11975
(Glyco_hydro_4C) 		4 VAL A 162
ILE A 165
ASN A 160
GLU A 344
 None
None
MN  A 601 ( 4.8A)
None
 1.08A 4a97H-3u95A:
undetectable		 4a97H-3u95A:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v9e LACCASE

(Botrytis aclada) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 PHE A 393
TYR A 397
VAL A 399
GLU A 390
 None
 1.03A 4a97H-3v9eA:
undetectable		 4a97H-3v9eA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vtz GLUCOSE
1-DEHYDROGENASE

(Thermoplasma
volcanium) 		PF13561
(adh_short_C2) 		4 TYR A 109
VAL A 105
ILE A 101
ASN A 106
 None
 0.93A 4a97H-3vtzA:
undetectable		 4a97H-3vtzA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w08 ALDOXIME DEHYDRATASE

(Pseudomonas
chlororaphis) 		PF13816
(Dehydratase_hem) 		4 TYR A 278
VAL A 276
ASN A 266
GLU A 321
 None
 1.14A 4a97H-3w08A:
undetectable		 4a97H-3w08A:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wiq KOJIBIOSE
PHOSPHORYLASE

(Caldicellulosiruptor
saccharolyticus) 		PF03632
(Glyco_hydro_65m)
PF03633
(Glyco_hydro_65C)
PF03636
(Glyco_hydro_65N) 		4 PHE A 655
VAL A 307
ILE A 311
ASN A 310
 None
 0.91A 4a97H-3wiqA:
0.1		 4a97H-3wiqA:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wr7 SPERMIDINE
N1-ACETYLTRANSFERASE

(Escherichia
coli) 		PF13302
(Acetyltransf_3) 		4 TYR A  30
VAL A 122
ILE A 130
ASN A 126
 COA  A 202 (-3.4A)
COA  A 202 ( 4.8A)
None
COA  A 202 ( 4.7A)
 1.11A 4a97H-3wr7A:
undetectable		 4a97H-3wr7A:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zq4 RIBONUCLEASE J 1

(Bacillus
subtilis) 		PF00753
(Lactamase_B)
PF07521
(RMMBL) 		4 PHE A 130
VAL A 128
ILE A 122
GLU A  32
 None
 1.09A 4a97H-3zq4A:
undetectable		 4a97H-3zq4A:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ae0 DIPHTHERIA TOXIN

(Corynebacterium
diphtheriae) 		PF01324
(Diphtheria_R)
PF02763
(Diphtheria_C)
PF02764
(Diphtheria_T) 		4 PHE A  17
VAL A 135
ILE A 150
ASN A 151
 None
 0.94A 4a97H-4ae0A:
undetectable		 4a97H-4ae0A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c8q DNA TOPOISOMERASE
2-ASSOCIATED PROTEIN
PAT1

(Saccharomyces
cerevisiae) 		PF09770
(PAT1) 		4 PHE H 681
VAL H 727
ILE H 724
GLU H 701
 None
None
None
CO  H1080 (-3.8A)
 1.00A 4a97H-4c8qH:
undetectable		 4a97H-4c8qH:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cag POLYSACCHARIDE LYASE
FAMILY 11 PROTEIN

(Bacillus
licheniformis) 		PF01839
(FG-GAP) 		4 PHE A 193
VAL A 279
ARG A 555
GLU A 200
 None
None
None
CA  A 605 (-2.0A)
 1.13A 4a97H-4cagA:
undetectable		 4a97H-4cagA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4crn ERF1 IN
RIBOSOME-BOUND
ERF1-ERF3-GDPNP
COMPLEX

(Saccharomyces
cerevisiae) 		PF03463
(eRF1_1)
PF03464
(eRF1_2)
PF03465
(eRF1_3) 		4 TYR X 277
VAL X   5
ILE X 387
ASN X   8
 None
 1.14A 4a97H-4crnX:
undetectable		 4a97H-4crnX:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4db3 N-ACETYL-D-GLUCOSAMI
NE KINASE

(Vibrio
vulnificus) 		PF00480
(ROK) 		4 VAL A 226
ILE A 211
ASN A 215
GLU A 263
 None
 1.05A 4a97H-4db3A:
undetectable		 4a97H-4db3A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dpy MEVALONATE
DIPHOSPHATE
DECARBOXYLASE

(Staphylococcus
epidermidis) 		PF00288
(GHMP_kinases_N) 		4 TYR A 279
VAL A 290
ILE A 179
GLU A 269
 None
 0.95A 4a97H-4dpyA:
undetectable		 4a97H-4dpyA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eg9 UNCHARACTERIZED
PROTEIN
SAOUHSC_02783

(Staphylococcus
aureus) 		PF04507
(DUF576) 		4 VAL A  95
ILE A  75
ASN A  77
GLU A 126
 None
 0.63A 4a97H-4eg9A:
undetectable		 4a97H-4eg9A:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h0p ACETATE KINASE

(Cryptococcus
neoformans) 		PF00871
(Acetate_kinase) 		4 PHE A 162
TYR A 196
VAL A 200
ILE A 214
 None
 1.13A 4a97H-4h0pA:
undetectable		 4a97H-4h0pA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hpf POTASSIUM CHANNEL
SUBFAMILY U MEMBER 1

(Homo sapiens) 		PF03493
(BK_channel_a) 		4 TYR A 917
ILE A 472
ASN A 471
GLU A 558
 None
 0.92A 4a97H-4hpfA:
undetectable		 4a97H-4hpfA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i8v CYTOCHROME P450 1A1

(Homo sapiens) 		PF00067
(p450) 		4 TYR A 207
VAL A 192
ARG A 206
ASN A 196
 None
 1.13A 4a97H-4i8vA:
undetectable		 4a97H-4i8vA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i8v CYTOCHROME P450 1A1

(Homo sapiens) 		PF00067
(p450) 		4 VAL A 192
ARG A 206
ASN A 196
GLU A 213
 None
 1.08A 4a97H-4i8vA:
undetectable		 4a97H-4i8vA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j1y COMPLEMENT C1S
SUBCOMPONENT

(Homo sapiens) 		PF00084
(Sushi)
PF00089
(Trypsin) 		4 TYR A 468
ILE A 465
ASN A 466
GLU A 506
 None
 1.14A 4a97H-4j1yA:
undetectable		 4a97H-4j1yA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jkx BETA-GALACTOSIDE-SPE
CIFIC LECTIN 1 A
CHAIN

(Viscum album) 		PF00161
(RIP) 		4 PHE A 214
VAL A 206
ILE A  37
ASN A  35
 None
 1.14A 4a97H-4jkxA:
undetectable		 4a97H-4jkxA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4my5 PUTATIVE AMINO ACID
AMINOTRANSFERASE

(Streptococcus
mutans) 		PF00155
(Aminotran_1_2) 		4 TYR A 208
ILE A 171
ASN A 173
GLU A  39
 None
 1.14A 4a97H-4my5A:
undetectable		 4a97H-4my5A:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p27 VENOM ALLERGEN-LIKE
(VAL) 4 PROTEIN

(Schistosoma
mansoni) 		PF00188
(CAP) 		4 PHE A  14
VAL A  18
ILE A  27
GLU A  85
 None
 0.96A 4a97H-4p27A:
undetectable		 4a97H-4p27A:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q8k ALGINASE

(Pseudoalteromonas
sp. SM0524) 		PF08787
(Alginate_lyase2) 		4 PHE A 239
TYR A 395
VAL A 393
ILE A 175
 None
 1.03A 4a97H-4q8kA:
undetectable		 4a97H-4q8kA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q8l ALGINASE

(Pseudoalteromonas
sp. SM0524) 		PF08787
(Alginate_lyase2) 		4 PHE A  72
TYR A 228
VAL A 226
ILE A   8
 None
 1.01A 4a97H-4q8lA:
undetectable		 4a97H-4q8lA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qni UNCHARACTERIZED
PROTEIN

(Bacteroides
thetaiotaomicron) 		PF14274
(DUF4361)
PF16343
(DUF4973) 		4 TYR A 328
VAL A 330
ILE A 200
ASN A 202
 None
None
EDO  A 403 ( 4.1A)
EDO  A 403 ( 4.9A)
 1.07A 4a97H-4qniA:
undetectable		 4a97H-4qniA:
20.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4twf CYS-LOOP
LIGAND-GATED ION
CHANNEL

(Dickeya
chrysanthemi) 		PF02931
(Neur_chan_LBD) 		5 PHE A  19
TYR A  38
VAL A  40
ARG A  91
ILE A 101
 None
 0.46A 4a97H-4twfA:
33.9		 4a97H-4twfA:
99.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4twf CYS-LOOP
LIGAND-GATED ION
CHANNEL

(Dickeya
chrysanthemi) 		PF02931
(Neur_chan_LBD) 		4 PHE A  19
VAL A  40
ARG A  91
ASN A 103
 None
 0.97A 4a97H-4twfA:
33.9		 4a97H-4twfA:
99.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4upi SULFATASE FAMILY
PROTEIN

(Ruegeria
pomeroyi) 		PF00884
(Sulfatase) 		4 TYR A 332
ARG A  16
ILE A 291
GLU A 261
 None
 1.00A 4a97H-4upiA:
undetectable		 4a97H-4upiA:
21.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4yeu CYS-LOOP
LIGAND-GATED ION
CHANNEL,PROTON-GATED
ION CHANNEL

(Dickeya
chrysanthemi;
Gloeobacter
violaceus) 		PF02931
(Neur_chan_LBD) 		6 PHE A  19
TYR A  38
VAL A  40
ARG A  91
ILE A 101
ASN A 103
 None
 0.56A 4a97H-4yeuA:
29.4		 4a97H-4yeuA:
71.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z81 EGF FAMILY
DOMAIN-CONTAINING
PROTEIN

(Toxoplasma
gondii) 		PF02430
(AMA-1)
PF07974
(EGF_2) 		4 PHE A 367
TYR A 368
VAL A 370
ILE A 154
 None
 1.11A 4a97H-4z81A:
undetectable		 4a97H-4z81A:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aee ALPHA-GLUCOSIDASE
YIHQ

(Escherichia
coli) 		PF01055
(Glyco_hydro_31) 		4 PHE A 530
VAL A 564
ARG A 560
ILE A 678
 None
 1.04A 4a97H-5aeeA:
undetectable		 4a97H-5aeeA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e9o CELLULASE, GLYCOSYL
HYDROLASE FAMILY 5,
TPS LINKER, DOMAIN X

(Spirochaeta
thermophila) 		no annotation 4 TYR A 526
ILE A 517
ASN A 503
GLU A 461
 None
 1.10A 4a97H-5e9oA:
undetectable		 4a97H-5e9oA:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5flz SPINDLE POLE BODY
COMPONENT SPC98

(Saccharomyces
cerevisiae) 		PF04130
(Spc97_Spc98) 		4 TYR B 187
VAL B 188
ILE B 224
GLU B 182
 None
 0.98A 4a97H-5flzB:
1.3		 4a97H-5flzB:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j78 ACETALDEHYDE
DEHYDROGENASE
(ACETYLATING)

(Parageobacillus
thermoglucosidasius) 		PF00171
(Aldedh) 		4 PHE A 359
VAL A 309
ILE A 337
GLU A 350
 None
 1.09A 4a97H-5j78A:
undetectable		 4a97H-5j78A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jb3 30S RIBOSOMAL
PROTEIN S3

(Pyrococcus
abyssi) 		PF00189
(Ribosomal_S3_C)
PF07650
(KH_2) 		4 TYR Z 166
VAL Z 180
ILE Z 130
GLU Z  22
 G  21010 ( 4.4A)
None
None
None
 1.10A 4a97H-5jb3Z:
undetectable		 4a97H-5jb3Z:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kkb MANNOSYL-OLIGOSACCHA
RIDE
1,2-ALPHA-MANNOSIDAS
E IA

(Mus musculus) 		PF01532
(Glyco_hydro_47) 		4 PHE A 479
VAL A 410
ILE A 446
GLU A 552
 None
None
None
LA  A 711 ( 4.6A)
 1.15A 4a97H-5kkbA:
undetectable		 4a97H-5kkbA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lmg DNA TOPOISOMERASE
2-ASSOCIATED PROTEIN
PAT1

(Saccharomyces
cerevisiae) 		PF09770
(PAT1) 		4 PHE A 681
VAL A 727
ILE A 724
GLU A 701
 None
None
None
EDO  A 804 (-2.9A)
 1.07A 4a97H-5lmgA:
0.8		 4a97H-5lmgA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lw7 ABC TRANSPORTER
ATP-BINDING PROTEIN

(Pyrococcus
abyssi) 		PF00005
(ABC_tran)
PF00037
(Fer4)
PF04068
(RLI) 		4 PHE B 322
TYR B 288
VAL B 286
ILE B 284
 None
 1.10A 4a97H-5lw7B:
undetectable		 4a97H-5lw7B:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mc5 XAA-PRO DIPEPTIDASE

(Homo sapiens) 		no annotation 4 PHE A  96
TYR A  83
VAL A  85
ILE A  45
 None
 0.66A 4a97H-5mc5A:
undetectable		 4a97H-5mc5A:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n0l GTP-SENSING
TRANSCRIPTIONAL
PLEIOTROPIC
REPRESSOR CODY

(Clostridioides
difficile) 		no annotation 4 PHE A  74
TYR A  78
VAL A  82
ILE A  85
 ILE  A 201 ( 4.7A)
None
None
None
 1.04A 4a97H-5n0lA:
undetectable		 4a97H-5n0lA:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tcb PELA

(Pseudomonas
aeruginosa) 		PF03537
(Glyco_hydro_114) 		4 PHE A 202
VAL A 217
ILE A 220
GLU A 203
 None
 1.09A 4a97H-5tcbA:
undetectable		 4a97H-5tcbA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5te1 ATP-CITRATE SYNTHASE

(Homo sapiens) 		PF00549
(Ligase_CoA)
PF02629
(CoA_binding)
PF16114
(Citrate_bind) 		4 PHE A 493
VAL A 568
ILE A 591
GLU A 683
 None
 1.07A 4a97H-5te1A:
undetectable		 4a97H-5te1A:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tet ATP-CITRATE SYNTHASE

(Homo sapiens) 		PF00549
(Ligase_CoA)
PF02629
(CoA_binding) 		4 PHE B 493
VAL B 568
ILE B 591
GLU B 683
 None
 1.08A 4a97H-5tetB:
undetectable		 4a97H-5tetB:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uwb TOLUENE TOLERANCE
PROTEIN

(Pseudomonas
putida) 		no annotation 4 TYR B 144
VAL B 164
ILE B 167
ASN B 165
 PEF  B 302 (-4.0A)
PEF  B 302 ( 4.6A)
None
PEF  B 302 ( 4.1A)
 0.95A 4a97H-5uwbB:
undetectable		 4a97H-5uwbB:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yfb DIPEPTIDYL PEPTIDASE
3

(Armillaria
tabescens) 		no annotation 4 TYR A 313
VAL A 314
ILE A 164
GLU A 324
 None
 1.02A 4a97H-5yfbA:
0.6		 4a97H-5yfbA:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6caa ELECTROGENIC SODIUM
BICARBONATE
COTRANSPORTER 1

(Homo sapiens) 		no annotation 4 PHE A 865
TYR A 862
VAL A 864
ILE A 692
 None
 1.09A 4a97H-6caaA:
0.7		 4a97H-6caaA:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d46 BETA SLIDING CLAMP

(Rickettsia
typhi) 		no annotation 4 PHE A 353
TYR A 352
VAL A 362
ILE A 376
 None
 1.02A 4a97H-6d46A:
undetectable		 4a97H-6d46A:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6deg BETA SLIDING CLAMP

(Bartonella
birtlesii) 		no annotation 4 PHE A  57
VAL A   5
ILE A  87
GLU A  55
 None
 1.14A 4a97H-6degA:
undetectable		 4a97H-6degA:
13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f36 MITOCHONDRIAL ATP
SYNTHASE SUBUNIT
ASA6

(Polytomella sp.
Pringsheim
198.80) 		no annotation 4 PHE N 129
TYR N 126
VAL N 125
ILE N 120
 None
 1.08A 4a97H-6f36N:
undetectable		 4a97H-6f36N:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bf6 PHOSPHOTRIESTERASE
HOMOLOGY PROTEIN

(Escherichia
coli) 		PF02126
(PTE) 		4 GLU A 108
ILE A 113
HIS A  12
VAL A 182
 None
None
ZN  A   1 (-3.5A)
None
 1.17A 4a97I-1bf6A:
undetectable		 4a97I-1bf6A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bg4 ENDO-1,4-BETA-XYLANA
SE

(Penicillium
simplicissimum) 		PF00331
(Glyco_hydro_10) 		4 GLU A  56
PHE A  62
HIS A  84
VAL A  71
 None
None
GOL  A 629 ( 3.8A)
None
 1.04A 4a97I-1bg4A:
undetectable		 4a97I-1bg4A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cdz PROTEIN (DNA-REPAIR
PROTEIN XRCC1)

(Homo sapiens) 		PF16589
(BRCT_2) 		4 GLU A  21
PHE A  17
HIS A  87
VAL A  44
 None
 1.21A 4a97I-1cdzA:
undetectable		 4a97I-1cdzA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ecg GLUTAMINE
PHOSPHORIBOSYLPYROPH
OSPHATE
AMIDOTRANSFERASE

(Escherichia
coli) 		PF00156
(Pribosyltran)
PF13522
(GATase_6) 		4 ILE A 407
PHE A 461
TYR A 258
VAL A 365
 None
None
PIN  A 506 ( 4.0A)
None
 1.24A 4a97I-1ecgA:
0.0		 4a97I-1ecgA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gom ENDO-1,4-BETA-XYLANA
SE

(Thermoascus
aurantiacus) 		PF00331
(Glyco_hydro_10) 		4 GLU A  55
PHE A  61
HIS A  83
VAL A  70
 None
 1.09A 4a97I-1gomA:
undetectable		 4a97I-1gomA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ikp EXOTOXIN A

(Pseudomonas
aeruginosa) 		PF09009
(Exotox-A_cataly)
PF09101
(Exotox-A_bind)
PF09102
(Exotox-A_target) 		4 GLU A 591
ILE A 594
TYR A 502
VAL A 455
 None
 1.06A 4a97I-1ikpA:
0.0		 4a97I-1ikpA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n81 PLASMODIUM
FALCIPARUM GAMETE
ANTIGEN 27/25

(Plasmodium
falciparum) 		PF09216
(Pfg27) 		4 GLU A  42
ILE A 101
PHE A  43
VAL A 172
 None
 1.21A 4a97I-1n81A:
3.1		 4a97I-1n81A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p15 PROTEIN-TYROSINE
PHOSPHATASE ALPHA

(Mus musculus) 		PF00102
(Y_phosphatase) 		4 ILE A 650
PHE A 609
HIS A 718
VAL A 708
 None
 1.24A 4a97I-1p15A:
0.0		 4a97I-1p15A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rqb TRANSCARBOXYLASE 5S
SUBUNIT

(Propionibacterium
freudenreichii) 		PF00682
(HMGL-like)
PF02436
(PYC_OADA) 		4 GLU A 255
ILE A 242
HIS A 217
VAL A 298
 None
None
CO  A 529 (-3.3A)
None
 1.19A 4a97I-1rqbA:
0.0		 4a97I-1rqbA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1su7 CARBON MONOXIDE
DEHYDROGENASE 2

(Carboxydothermus
hydrogenoformans) 		PF03063
(Prismane) 		4 ILE A 190
PHE A 154
HIS A 261
VAL A 264
 None
None
NFS  A 639 (-3.3A)
None
 1.09A 4a97I-1su7A:
undetectable		 4a97I-1su7A:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sus CAFFEOYL-COA
O-METHYLTRANSFERASE

(Medicago sativa) 		PF01596
(Methyltransf_3) 		4 GLU A  85
ILE A 107
HIS A  43
VAL A  38
 SAH  A 301 (-4.1A)
None
None
None
 0.98A 4a97I-1susA:
undetectable		 4a97I-1susA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sy7 CATALASE 1

(Neurospora
crassa) 		PF00199
(Catalase)
PF01965
(DJ-1_PfpI)
PF06628
(Catalase-rel) 		4 ILE A 396
PHE A 355
TYR A 154
VAL A 116
 None
HEM  A1883 ( 4.4A)
None
None
 1.16A 4a97I-1sy7A:
undetectable		 4a97I-1sy7A:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tnu GERANYLGERANYL
TRANSFERASE TYPE I
BETA SUBUNIT

(Rattus
norvegicus) 		PF00432
(Prenyltrans) 		4 GLU B 334
ILE B 337
HIS B 321
VAL B 268
 None
None
ZN  B 378 (-3.4A)
None
 1.24A 4a97I-1tnuB:
undetectable		 4a97I-1tnuB:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u2v ACTIN-RELATED
PROTEIN 3

(Bos taurus) 		PF00022
(Actin) 		4 ILE A 281
PHE A 283
HIS A 176
VAL A 303
 None
 1.21A 4a97I-1u2vA:
undetectable		 4a97I-1u2vA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v4g GLUTAMATE--CYSTEINE
LIGASE

(Escherichia
coli) 		PF04262
(Glu_cys_ligase) 		4 ILE A  57
PHE A  82
HIS A 150
VAL A 347
 None
 1.19A 4a97I-1v4gA:
undetectable		 4a97I-1v4gA:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x1q TRYPTOPHAN SYNTHASE
BETA CHAIN

(Thermus
thermophilus) 		PF00291
(PALP) 		4 GLU A 336
ILE A 260
PHE A  30
VAL A  38
 None
CL  A1001 (-4.0A)
None
None
 1.06A 4a97I-1x1qA:
undetectable		 4a97I-1x1qA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y63 LMAJ004144AAA
PROTEIN

(Leishmania
major) 		PF13238
(AAA_18) 		4 GLU A  69
ILE A  64
TYR A  90
VAL A 104
 None
None
MN  A 356 ( 4.7A)
None
 1.00A 4a97I-1y63A:
undetectable		 4a97I-1y63A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y7n AMYLOID BETA A4
PRECURSOR
PROTEIN-BINDING
FAMILY A MEMBER 1

(Homo sapiens) 		PF00595
(PDZ) 		4 ILE A  43
PHE A  28
HIS A  83
VAL A  12
 None
 1.19A 4a97I-1y7nA:
undetectable		 4a97I-1y7nA:
13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2czr TBP-INTERACTING
PROTEIN

(Thermococcus
kodakarensis) 		PF15517
(TBPIP_N) 		4 GLU A 151
ILE A 170
TYR A 147
HIS A 179
 None
 1.11A 4a97I-2czrA:
undetectable		 4a97I-2czrA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e3z BETA-GLUCOSIDASE

(Phanerochaete
chrysosporium) 		PF00232
(Glyco_hydro_1) 		4 GLU A  22
ILE A  21
TYR A  76
VAL A 111
 None
 1.06A 4a97I-2e3zA:
undetectable		 4a97I-2e3zA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ee6 FILAMIN-B

(Homo sapiens) 		PF00630
(Filamin) 		4 ILE A  56
PHE A  58
HIS A  88
VAL A  14
 None
 1.19A 4a97I-2ee6A:
undetectable		 4a97I-2ee6A:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gz3 ASPARTATE
BETA-SEMIALDEHYDE
DEHYDROGENASE

(Streptococcus
pneumoniae) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		4 GLU A 282
ILE A 289
PHE A 303
VAL A 248
 None
 1.24A 4a97I-2gz3A:
undetectable		 4a97I-2gz3A:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hpw GREEN FLUORESCENT
PROTEIN

(Clytia gregaria) 		PF01353
(GFP) 		4 GLU A 224
ILE A  45
TYR A  49
VAL A  58
 GYS  A  68 ( 3.4A)
GYS  A  68 ( 4.3A)
None
None
 1.12A 4a97I-2hpwA:
undetectable		 4a97I-2hpwA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ihy ABC TRANSPORTER,
ATP-BINDING PROTEIN

(Staphylococcus
aureus) 		PF00005
(ABC_tran) 		4 GLU A  95
PHE A  91
HIS A 124
VAL A 130
 None
 1.09A 4a97I-2ihyA:
undetectable		 4a97I-2ihyA:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iik 3-KETOACYL-COA
THIOLASE,
PEROXISOMAL

(Homo sapiens) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		4 GLU A 223
ILE A 389
PHE A 220
HIS A 378
 None
 1.16A 4a97I-2iikA:
undetectable		 4a97I-2iikA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ixd LMBE-RELATED PROTEIN

(Bacillus cereus) 		PF02585
(PIG-L) 		4 PHE A 217
TYR A  27
HIS A   5
VAL A  66
 None
 1.24A 4a97I-2ixdA:
undetectable		 4a97I-2ixdA:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j4x MITOGEN

(Streptococcus
dysgalactiae) 		PF02876
(Stap_Strp_tox_C) 		4 GLU A 191
PHE A 136
TYR A 171
HIS A 170
 None
None
None
ZN  A1211 (-3.1A)
 1.22A 4a97I-2j4xA:
undetectable		 4a97I-2j4xA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l8o UNCHARACTERIZED
PROTEIN

(Cytophaga
hutchinsonii) 		PF08327
(AHSA1) 		4 GLU A 105
ILE A  92
HIS A  26
VAL A  39
 None
 1.15A 4a97I-2l8oA:
undetectable		 4a97I-2l8oA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nux 2-KETO-3-DEOXYGLUCON
ATE/2-KETO-3-DEOXY-6
-PHOSPHO GLUCONATE
ALDOLASE

(Sulfolobus
acidocaldarius) 		PF00701
(DHDPS) 		4 GLU A   2
ILE A   4
TYR A 127
HIS A 124
 None
 1.18A 4a97I-2nuxA:
undetectable		 4a97I-2nuxA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o04 PECTATE LYASE

(Bacillus
subtilis) 		PF00544
(Pec_lyase_C) 		4 ILE A 196
TYR A 242
HIS A 243
VAL A 277
 None
 0.98A 4a97I-2o04A:
undetectable		 4a97I-2o04A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2odf HYPOTHETICAL PROTEIN
ATU2144

(Agrobacterium
fabrum) 		PF05013
(FGase) 		4 ILE A  38
PHE A   8
HIS A  33
VAL A  78
 None
 1.21A 4a97I-2odfA:
undetectable		 4a97I-2odfA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2owo DNA LIGASE

(Escherichia
coli) 		PF01653
(DNA_ligase_aden)
PF03119
(DNA_ligase_ZBD)
PF03120
(DNA_ligase_OB)
PF12826
(HHH_2)
PF14520
(HHH_5) 		4 ILE A 573
PHE A 508
HIS A 561
VAL A 552
 None
 0.92A 4a97I-2owoA:
2.5		 4a97I-2owoA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qf7 PYRUVATE CARBOXYLASE
PROTEIN

(Rhizobium etli) 		PF00289
(Biotin_carb_N)
PF00364
(Biotin_lipoyl)
PF00682
(HMGL-like)
PF02436
(PYC_OADA)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 ILE A 270
TYR A 284
HIS A 216
VAL A 211
 None
None
AGS  A1162 (-3.9A)
AGS  A1162 ( 4.6A)
 1.23A 4a97I-2qf7A:
undetectable		 4a97I-2qf7A:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v26 MYOSIN VI

(Sus scrofa) 		PF00063
(Myosin_head) 		4 GLU A 478
ILE A 515
PHE A 582
VAL A 697
 None
 1.15A 4a97I-2v26A:
2.5		 4a97I-2v26A:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w82 ORF18

(Enterococcus
faecalis) 		PF07275
(ArdA) 		4 GLU A 162
ILE A 105
PHE A 153
TYR A 119
 None
 1.20A 4a97I-2w82A:
undetectable		 4a97I-2w82A:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wdu GLUTATHIONE
TRANSFERASE SIGMA
CLASS

(Fasciola
hepatica) 		PF14497
(GST_C_3) 		4 GLU A 101
ILE A  98
HIS A 169
VAL A 174
 None
None
BR  A1218 (-3.7A)
None
 1.21A 4a97I-2wduA:
4.6		 4a97I-2wduA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x2i ALPHA-1,4-GLUCAN
LYASE ISOZYME 1

(Gracilariopsis
lemaneiformis) 		PF01055
(Glyco_hydro_31) 		4 ILE A 147
TYR A  89
HIS A 325
VAL A 337
 None
None
None
CSO  A 336 ( 3.4A)
 0.99A 4a97I-2x2iA:
undetectable		 4a97I-2x2iA:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yn9 POTASSIUM-TRANSPORTI
NG ATPASE ALPHA
CHAIN 1

(Sus scrofa) 		PF00122
(E1-E2_ATPase)
PF00689
(Cation_ATPase_C)
PF00690
(Cation_ATPase_N)
PF09040
(H-K_ATPase_N)
PF13246
(Cation_ATPase) 		4 ILE A 816
PHE A 931
TYR A 799
VAL A 805
 None
 0.92A 4a97I-2yn9A:
2.8		 4a97I-2yn9A:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yyz SUGAR ABC
TRANSPORTER,
ATP-BINDING PROTEIN

(Thermotoga
maritima) 		PF00005
(ABC_tran)
PF08402
(TOBE_2) 		4 GLU A 320
ILE A 322
HIS A 348
VAL A 271
 None
 1.20A 4a97I-2yyzA:
undetectable		 4a97I-2yyzA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b78 EXOTOXIN A

(Pseudomonas
aeruginosa) 		PF09009
(Exotox-A_cataly) 		4 GLU B 591
ILE B 594
TYR B 502
VAL B 455
 None
None
None
NAD  B 700 ( 3.6A)
 1.14A 4a97I-3b78B:
undetectable		 4a97I-3b78B:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dul O-METHYLTRANSFERASE,
PUTATIVE

(Bacillus cereus) 		PF01596
(Methyltransf_3) 		4 ILE A  65
PHE A 138
HIS A  95
VAL A  28
 None
 1.18A 4a97I-3dulA:
undetectable		 4a97I-3dulA:
25.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dwl ACTIN-RELATED
PROTEIN 3

(Schizosaccharomyces
pombe) 		PF00022
(Actin) 		4 ILE A 292
PHE A 294
HIS A 192
VAL A 314
 None
 1.08A 4a97I-3dwlA:
undetectable		 4a97I-3dwlA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iz3 STRUCTURAL PROTEIN
VP1

(Cypovirus 1) 		no annotation 4 ILE B 766
PHE B 691
TYR B 772
HIS B 701
 None
 0.87A 4a97I-3iz3B:
2.5		 4a97I-3iz3B:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k55 BETA-HEMOLYSIN

(Staphylococcus
aureus) 		PF03372
(Exo_endo_phos) 		4 ILE A 183
TYR A 134
HIS A 116
VAL A 102
 None
 1.00A 4a97I-3k55A:
undetectable		 4a97I-3k55A:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k85 D-GLYCERO-D-MANNO-HE
PTOSE 1-PHOSPHATE
KINASE

(Bacteroides
thetaiotaomicron) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		4 ILE A 180
PHE A 173
TYR A 137
VAL A 120
 None
 1.22A 4a97I-3k85A:
undetectable		 4a97I-3k85A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nrd HISTIDINE TRIAD
(HIT) PROTEIN

(Sinorhizobium
meliloti) 		PF01230
(HIT) 		4 GLU A  50
ILE A  45
PHE A  49
HIS A  94
 None
None
None
SO4  A 207 (-3.9A)
 1.20A 4a97I-3nrdA:
undetectable		 4a97I-3nrdA:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ohw PHYCOBILISOME LCM
CORE-MEMBRANE LINKER
POLYPEPTIDE

(Synechocystis
sp. PCC 6803) 		no annotation 4 GLU B 764
ILE B 756
HIS B 807
VAL B 839
 None
 1.20A 4a97I-3ohwB:
undetectable		 4a97I-3ohwB:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p8c NCK-ASSOCIATED
PROTEIN 1

(Homo sapiens) 		PF09735
(Nckap1) 		4 ILE B 733
PHE B 825
HIS B 858
VAL B 912
 None
 1.15A 4a97I-3p8cB:
0.1		 4a97I-3p8cB:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p8c NCK-ASSOCIATED
PROTEIN 1

(Homo sapiens) 		PF09735
(Nckap1) 		4 ILE B 733
PHE B 825
TYR B 792
VAL B 912
 None
 1.21A 4a97I-3p8cB:
0.1		 4a97I-3p8cB:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pm6 PUTATIVE
FRUCTOSE-BISPHOSPHAT
E ALDOLASE

(Coccidioides
immitis) 		PF01116
(F_bP_aldolase) 		4 ILE A 289
PHE A 228
HIS A  84
VAL A 157
 None
 1.22A 4a97I-3pm6A:
undetectable		 4a97I-3pm6A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rko NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT M
NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT N

(Escherichia
coli) 		no annotation 4 GLU M 108
ILE M 109
HIS N 435
VAL N 430
 None
 1.15A 4a97I-3rkoM:
4.0		 4a97I-3rkoM:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sqw ATP-DEPENDENT RNA
HELICASE MSS116,
MITOCHONDRIAL

(Saccharomyces
cerevisiae) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		4 GLU A 484
ILE A 480
PHE A 352
VAL A 515
 None
 1.17A 4a97I-3sqwA:
undetectable		 4a97I-3sqwA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sun DNA POLYMERASE

(Escherichia
virus RB69) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		4 GLU A 297
ILE A 334
PHE A 296
VAL A 782
 None
 1.19A 4a97I-3sunA:
3.4		 4a97I-3sunA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tgh GLIDEOSOME-ASSOCIATE
D PROTEIN 50

(Plasmodium
falciparum) 		PF00149
(Metallophos) 		4 PHE A  29
TYR A 153
HIS A 152
VAL A 102
 None
 0.98A 4a97I-3tghA:
undetectable		 4a97I-3tghA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4anj UNCONVENTIONAL
MYOSIN-VI, GREEN
FLUORESCENT PROTEIN

(Aequorea
victoria;
Sus scrofa) 		PF00063
(Myosin_head)
PF01353
(GFP) 		4 GLU A 478
ILE A 515
PHE A 582
VAL A 697
 None
 1.20A 4a97I-4anjA:
2.4		 4a97I-4anjA:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4btf MIXED LINEAGE KINASE
DOMAIN-LIKE PROTEIN

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		4 GLU A 338
ILE A 254
PHE A 337
VAL A 388
 None
 1.05A 4a97I-4btfA:
3.7		 4a97I-4btfA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4db4 ATP-DEPENDENT RNA
HELICASE MSS116,
MITOCHONDRIAL

(Saccharomyces
cerevisiae) 		PF00271
(Helicase_C) 		4 GLU A 484
ILE A 480
PHE A 352
VAL A 515
 None
 1.21A 4a97I-4db4A:
undetectable		 4a97I-4db4A:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4di5 5-EPI-ARISTOLOCHENE
SYNTHASE

(Nicotiana
tabacum) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		4 GLU A 280
PHE A 279
HIS A 199
VAL A 518
 None
 1.23A 4a97I-4di5A:
3.8		 4a97I-4di5A:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dmo N-HYDROXYARYLAMINE
O-ACETYLTRANSFERASE

(Bacillus cereus) 		PF00797
(Acetyltransf_2) 		4 ILE A  43
TYR A  70
HIS A 108
VAL A 191
 None
 1.03A 4a97I-4dmoA:
undetectable		 4a97I-4dmoA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4em6 GLUCOSE-6-PHOSPHATE
ISOMERASE

(Brucella
melitensis) 		no annotation 4 GLU D 400
ILE D 333
HIS D 490
VAL D  74
 None
 1.17A 4a97I-4em6D:
2.2		 4a97I-4em6D:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f4c MULTIDRUG RESISTANCE
PROTEIN PGP-1

(Caenorhabditis
elegans) 		PF00005
(ABC_tran)
PF00664
(ABC_membrane) 		4 ILE A 106
PHE A 778
HIS A 234
VAL A 362
 None
 1.04A 4a97I-4f4cA:
undetectable		 4a97I-4f4cA:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f7k LACCASE

(uncultured
bacterium) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 ILE A 297
PHE A 244
HIS A 153
VAL A 194
 None
 0.85A 4a97I-4f7kA:
undetectable		 4a97I-4f7kA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ghk GAMMA-GLUTAMYL
PHOSPHATE REDUCTASE

(Burkholderia
thailandensis) 		PF00171
(Aldedh) 		4 ILE A 392
PHE A 384
HIS A 231
VAL A 246
 None
 1.21A 4a97I-4ghkA:
undetectable		 4a97I-4ghkA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4glx DNA LIGASE

(Escherichia
coli) 		PF01653
(DNA_ligase_aden)
PF03119
(DNA_ligase_ZBD)
PF03120
(DNA_ligase_OB)
PF12826
(HHH_2)
PF14520
(HHH_5) 		4 ILE A 573
PHE A 508
HIS A 561
VAL A 552
 None
 0.98A 4a97I-4glxA:
2.7		 4a97I-4glxA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nzr PGT135 HEAVY CHAIN
PROTEIN M TD

(Homo sapiens;
Mycoplasma
genitalium) 		PF07654
(C1-set)
PF07686
(V-set)
no annotation 		4 GLU M 427
ILE M 449
TYR H  32
HIS H  95
 None
 0.80A 4a97I-4nzrM:
undetectable		 4a97I-4nzrM:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ph9 PROSTAGLANDIN G/H
SYNTHASE 2

(Mus musculus) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		4 ILE A 565
PHE A 199
TYR A 302
HIS A 233
 None
 1.23A 4a97I-4ph9A:
undetectable		 4a97I-4ph9A:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pxl CYTOSOLIC ALDEHYDE
DEHYDROGENASE RF2C

(Zea mays) 		PF00171
(Aldedh) 		4 ILE A 123
TYR A 205
HIS A 207
VAL A 214
 None
 1.23A 4a97I-4pxlA:
undetectable		 4a97I-4pxlA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qiw DNA-DIRECTED RNA
POLYMERASE

(Thermococcus
kodakarensis) 		PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4) 		4 ILE A 637
TYR A 626
HIS A 507
VAL A 660
 None
 1.23A 4a97I-4qiwA:
2.6		 4a97I-4qiwA:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r4g PUTATIVE LIPOPROTEIN
YCDA

(Bacillus
subtilis) 		PF11611
(DUF4352)
PF17118
(DUF5105) 		4 GLU A 354
ILE A 352
TYR A 307
VAL A 284
 None
 1.13A 4a97I-4r4gA:
3.4		 4a97I-4r4gA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r4g PUTATIVE LIPOPROTEIN
YCDA

(Bacillus
subtilis) 		PF11611
(DUF4352)
PF17118
(DUF5105) 		4 GLU A 354
ILE A 352
TYR A 307
VAL A 300
 None
 0.95A 4a97I-4r4gA:
3.4		 4a97I-4r4gA:
21.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4twf CYS-LOOP
LIGAND-GATED ION
CHANNEL

(Dickeya
chrysanthemi) 		PF02931
(Neur_chan_LBD) 		4 GLU A  77
ILE A  79
PHE A 133
TYR A 175
 BR7  A 401 ( 4.9A)
None
BR7  A 401 (-4.5A)
BR7  A 401 (-3.9A)
 0.49A 4a97I-4twfA:
33.9		 4a97I-4twfA:
99.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tz0 ATP-DEPENDENT RNA
HELICASE MSS116,
MITOCHONDRIAL

(Saccharomyces
cerevisiae) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		4 GLU A 484
ILE A 480
PHE A 352
VAL A 515
 None
 1.23A 4a97I-4tz0A:
undetectable		 4a97I-4tz0A:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x0q DNA POLYMERASE THETA

(Homo sapiens) 		PF00476
(DNA_pol_A) 		4 GLU A2049
ILE A2053
HIS A2236
VAL A2232
 None
None
None
GOL  A2602 (-4.5A)
 0.97A 4a97I-4x0qA:
undetectable		 4a97I-4x0qA:
16.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4yeu CYS-LOOP
LIGAND-GATED ION
CHANNEL,PROTON-GATED
ION CHANNEL

(Dickeya
chrysanthemi;
Gloeobacter
violaceus) 		PF02931
(Neur_chan_LBD) 		5 GLU A  77
ILE A  79
PHE A 133
TYR A 175
HIS A 177
 None
 0.75A 4a97I-4yeuA:
29.5		 4a97I-4yeuA:
71.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zv9 UNCHARACTERIZED
PROTEIN

(Escherichia
coli) 		PF01738
(DLH) 		4 GLU A  71
ILE A  73
PHE A  69
TYR A 173
 None
 1.24A 4a97I-4zv9A:
undetectable		 4a97I-4zv9A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eb5 HNL ISOENZYME 5

(Prunus dulcis) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		4 ILE A 127
PHE A 121
TYR A 509
VAL A 141
 None
 1.19A 4a97I-5eb5A:
undetectable		 4a97I-5eb5A:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ehk LANTIBIOTIC
DEHYDRATASE

(Microbispora
corallina) 		PF04738
(Lant_dehydr_N)
PF14028
(Lant_dehydr_C) 		4 GLU A 606
ILE A 607
HIS A 533
VAL A 640
 None
 1.10A 4a97I-5ehkA:
undetectable		 4a97I-5ehkA:
12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fi0 PHOSPHATIDYLINOSITOL
3,4,5-TRISPHOSPHATE-
DEPENDENT RAC
EXCHANGER 1
PROTEIN,PHOSPHATIDYL
INOSITOL
3,4,5-TRISPHOSPHATE-
DEPENDENT RAC
EXCHANGER 1 PROTEIN

(Homo sapiens) 		PF00169
(PH)
PF00621
(RhoGEF) 		4 ILE A 331
PHE A 291
HIS A 349
VAL A 355
 None
 1.07A 4a97I-5fi0A:
3.1		 4a97I-5fi0A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fwm HEAT SHOCK PROTEIN
HSP 90 BETA

(Homo sapiens) 		PF00183
(HSP90)
PF02518
(HATPase_c) 		4 ILE A 441
TYR A 457
HIS A 458
VAL A 494
 None
 1.15A 4a97I-5fwmA:
undetectable		 4a97I-5fwmA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h28 OXYSTEROL-BINDING
PROTEIN HOMOLOG 1

(Saccharomyces
cerevisiae) 		PF13637
(Ank_4) 		4 ILE A  86
PHE A  40
HIS A  57
VAL A  62
 None
 1.08A 4a97I-5h28A:
undetectable		 4a97I-5h28A:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hmp UNCONVENTIONAL
MYOSIN-VC

(Homo sapiens) 		PF00063
(Myosin_head) 		4 GLU A 457
ILE A 494
PHE A 551
HIS A 466
 None
 1.00A 4a97I-5hmpA:
undetectable		 4a97I-5hmpA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i5j NITROUS-OXIDE
REDUCTASE

(Shewanella
denitrificans) 		no annotation 4 ILE A 188
PHE A 274
HIS A 318
VAL A 313
 None
 1.23A 4a97I-5i5jA:
undetectable		 4a97I-5i5jA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ikr PROSTAGLANDIN G/H
SYNTHASE 2

(Homo sapiens) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		4 ILE A 564
PHE A 198
TYR A 301
HIS A 232
 None
 1.22A 4a97I-5ikrA:
undetectable		 4a97I-5ikrA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j6s ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 2

(Homo sapiens) 		PF01433
(Peptidase_M1)
PF11838
(ERAP1_C) 		4 GLU A 410
TYR A 298
HIS A 297
VAL A 284
 None
 1.23A 4a97I-5j6sA:
4.4		 4a97I-5j6sA:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k94 MALTOSE-BINDING
PERIPLASMIC
PROTEIN,PROTEIN
TRANSLOCASE SUBUNIT
SECA,MALTOSE-BINDING
PERIPLASMIC PROTEIN

(Escherichia
coli) 		PF01043
(SecA_PP_bind)
PF01547
(SBP_bac_1)
PF13416
(SBP_bac_8) 		4 GLU A 358
ILE A 365
HIS A 308
VAL A 272
 None
 1.20A 4a97I-5k94A:
undetectable		 4a97I-5k94A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kvp ZOOCIN A
ENDOPEPTIDASE

(Streptococcus
equi) 		PF01551
(Peptidase_M23) 		4 ILE A  93
PHE A  57
HIS A 120
VAL A  35
 None
 1.14A 4a97I-5kvpA:
undetectable		 4a97I-5kvpA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kz5 CYSTEINE
DESULFURASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00266
(Aminotran_5) 		4 GLU 1 416
TYR 1 317
HIS 1 319
VAL 1 310
 None
 0.94A 4a97I-5kz51:
undetectable		 4a97I-5kz51:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l3x NEGATIVE ELONGATION
FACTOR C/D

(Homo sapiens) 		PF04858
(TH1) 		4 PHE B 333
TYR B 356
HIS B 354
VAL B 390
 None
 1.10A 4a97I-5l3xB:
undetectable		 4a97I-5l3xB:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m0k BETA-XYLANASE

(Cellulomonas
flavigena) 		no annotation 4 GLU A  53
PHE A  59
HIS A  81
VAL A  68
 None
 0.99A 4a97I-5m0kA:
undetectable		 4a97I-5m0kA:
12.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mrj BETA-XYLANASE

(Acremonium
chrysogenum) 		no annotation 4 GLU A 145
PHE A 151
HIS A 173
VAL A 160
 None
 1.12A 4a97I-5mrjA:
undetectable		 4a97I-5mrjA:
9.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nny WIPB

(Legionella
pneumophila) 		no annotation 4 ILE A 278
PHE A 246
HIS A 231
VAL A 228
 None
 1.10A 4a97I-5nnyA:
undetectable		 4a97I-5nnyA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5of4 GENERAL
TRANSCRIPTION FACTOR
IIH SUBUNIT 2

(Homo sapiens) 		PF04056
(Ssl1) 		4 ILE E 170
PHE E  91
TYR E 228
HIS E 227
 None
 1.06A 4a97I-5of4E:
undetectable		 4a97I-5of4E:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tch TRYPTOPHAN SYNTHASE
BETA CHAIN

(Mycobacterium
tuberculosis) 		PF00291
(PALP) 		4 GLU B 326
ILE B 252
PHE B  19
VAL B  30
 None
 1.06A 4a97I-5tchB:
undetectable		 4a97I-5tchB:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xd6 PROTEIN KINASE
SUPERFAMILY PROTEIN

(Arabidopsis
thaliana) 		no annotation 4 ILE A 215
PHE A 262
HIS A 150
VAL A 287
 None
 1.22A 4a97I-5xd6A:
undetectable		 4a97I-5xd6A:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xjy ATP-BINDING CASSETTE
SUB-FAMILY A MEMBER
1

(Homo sapiens) 		PF00005
(ABC_tran)
PF12698
(ABC2_membrane_3) 		4 ILE A1677
PHE A1675
HIS A1686
VAL A1693
 None
 1.17A 4a97I-5xjyA:
3.0		 4a97I-5xjyA:
9.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z06 BDI_3064 PROTEIN

(Parabacteroides
distasonis) 		no annotation 4 GLU A 482
PHE A 553
TYR A 517
VAL A 524
 GOL  A 805 ( 2.6A)
GOL  A 805 (-4.4A)
GOL  A 805 (-4.6A)
None
 1.13A 4a97I-5z06A:
2.2		 4a97I-5z06A:
12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c8v COENZYME PQQ
SYNTHESIS PROTEIN E

(Methylobacterium
extorquens) 		no annotation 4 GLU A 272
TYR A 281
HIS A 285
VAL A  56
 None
 1.24A 4a97I-6c8vA:
undetectable		 4a97I-6c8vA:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cfw MBH13 NADH
DEHYDROGENASE
SUBUNIT
MEMBRANE-BOUND
HYDROGENASE SUBUNIT
ALPHA

(Pyrococcus
furiosus) 		no annotation 4 ILE M 287
PHE M 204
TYR L 124
VAL L 366
 None
 1.10A 4a97I-6cfwM:
5.1		 4a97I-6cfwM:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d6v TELOMERASE-ASSOCIATE
D PROTEIN 82

(Tetrahymena
thermophila) 		no annotation 4 GLU D 632
ILE D 631
HIS D 584
VAL D 562
 None
 1.07A 4a97I-6d6vD:
undetectable		 4a97I-6d6vD:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gne -

(-) 		no annotation 4 GLU A 370
PHE A 371
TYR A 347
VAL A 327
 None
 1.05A 4a97I-6gneA:
undetectable		 4a97I-6gneA:
undetectable