SIMILAR PATTERNS OF AMINO ACIDS FOR 4A97_H_ZPCH1318

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1air PECTATE LYASE C

(Dickeya
chrysanthemi) 		PF00544
(Pec_lyase_C) 		4 PHE A 103
VAL A  82
ILE A  33
GLU A  60
 None
 1.02A 4a97G-1airA:
undetectable		 4a97G-1airA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bf6 PHOSPHOTRIESTERASE
HOMOLOGY PROTEIN

(Escherichia
coli) 		PF02126
(PTE) 		4 PHE A   3
VAL A  78
ARG A 153
ILE A 122
 None
 1.04A 4a97G-1bf6A:
undetectable		 4a97G-1bf6A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f82 BOTULINUM NEUROTOXIN
TYPE B

(Clostridium
botulinum) 		PF01742
(Peptidase_M27) 		4 PHE A 154
VAL A 135
ARG A  27
ILE A 132
 None
 1.02A 4a97G-1f82A:
0.0		 4a97G-1f82A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kfu M-CALPAIN LARGE
SUBUNIT

(Homo sapiens) 		PF00648
(Peptidase_C2)
PF01067
(Calpain_III)
PF13833
(EF-hand_8) 		4 PHE L 475
VAL L 409
ILE L 499
GLU L 460
 None
 0.79A 4a97G-1kfuL:
0.0		 4a97G-1kfuL:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nba N-CARBAMOYLSARCOSINE
AMIDOHYDROLASE

(Arthrobacter
sp.) 		PF00857
(Isochorismatase) 		4 VAL A  75
MET A  68
ILE A  71
GLU A 139
 None
 0.90A 4a97G-1nbaA:
0.0		 4a97G-1nbaA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nbq JUNCTIONAL ADHESION
MOLECULE 1

(Homo sapiens) 		PF07686
(V-set)
PF13927
(Ig_3) 		4 PHE A  55
TYR A  52
VAL A  31
GLU A 113
 None
 1.09A 4a97G-1nbqA:
0.0		 4a97G-1nbqA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nf2 PHOSPHATASE

(Thermotoga
maritima) 		PF08282
(Hydrolase_3) 		4 TYR A  36
VAL A  38
ILE A  63
GLU A 208
 None
 1.06A 4a97G-1nf2A:
undetectable		 4a97G-1nf2A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nt2 FIBRILLARIN-LIKE
PRE-RRNA PROCESSING
PROTEIN

(Archaeoglobus
fulgidus) 		PF01269
(Fibrillarin) 		4 TYR A 208
VAL A 157
ILE A 130
GLU A 184
 None
 1.01A 4a97G-1nt2A:
0.0		 4a97G-1nt2A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qdl PROTEIN
(ANTHRANILATE
SYNTHASE
(TRPE-SUBUNIT))

(Sulfolobus
solfataricus) 		PF00425
(Chorismate_bind)
PF04715
(Anth_synt_I_N) 		4 TYR A  41
VAL A  43
ILE A 118
GLU A 371
 None
 1.00A 4a97G-1qdlA:
0.0		 4a97G-1qdlA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qjo DIHYDROLIPOAMIDE
ACETYLTRANSFERASE

(Escherichia
coli) 		PF00364
(Biotin_lipoyl) 		4 VAL A  65
MET A  72
ILE A  71
GLU A  38
 None
 0.93A 4a97G-1qjoA:
undetectable		 4a97G-1qjoA:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rrh SEED LIPOXYGENASE-3

(Glycine max) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		4 PHE A  53
VAL A  58
ILE A 117
ASN A 119
 None
 1.09A 4a97G-1rrhA:
undetectable		 4a97G-1rrhA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tp8 AGGLUTININ ALPHA
CHAIN

(Artocarpus
hirsutus) 		PF01419
(Jacalin) 		4 PHE A 104
TYR A  71
VAL A  81
ILE A  25
 None
 1.08A 4a97G-1tp8A:
undetectable		 4a97G-1tp8A:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1twd COPPER HOMEOSTASIS
PROTEIN CUTC

(Shigella
flexneri) 		PF03932
(CutC) 		4 VAL A 118
MET A 106
ILE A 109
GLU A   5
 None
 1.08A 4a97G-1twdA:
undetectable		 4a97G-1twdA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vpk DNA POLYMERASE III,
BETA SUBUNIT

(Thermotoga
maritima) 		PF00712
(DNA_pol3_beta)
PF02767
(DNA_pol3_beta_2)
PF02768
(DNA_pol3_beta_3) 		4 PHE A  68
VAL A  70
MET A  78
ILE A  75
 None
 1.04A 4a97G-1vpkA:
undetectable		 4a97G-1vpkA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wu8 HYPOTHETICAL PROTEIN
PH0463

(Pyrococcus
horikoshii) 		PF01887
(SAM_adeno_trans) 		4 TYR A  85
VAL A  87
ILE A 109
GLU A 140
 None
 1.10A 4a97G-1wu8A:
undetectable		 4a97G-1wu8A:
24.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xew SMC PROTEIN

(Pyrococcus
furiosus) 		PF02463
(SMC_N) 		4 PHE X  12
TYR X  15
VAL X  82
ILE X  84
 None
 0.97A 4a97G-1xewX:
undetectable		 4a97G-1xewX:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xl3 PROTEIN TYPE A

(Yersinia pestis) 		PF09059
(TyeA) 		4 PHE C  60
VAL C  16
MET C   9
ILE C  12
 None
 1.06A 4a97G-1xl3C:
undetectable		 4a97G-1xl3C:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xmx HYPOTHETICAL PROTEIN
VC1899

(Vibrio cholerae) 		PF09002
(DUF1887) 		4 PHE A 106
TYR A 109
VAL A  87
ILE A   3
 None
 0.93A 4a97G-1xmxA:
undetectable		 4a97G-1xmxA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yal CHYMOPAPAIN

(Carica papaya) 		PF00112
(Peptidase_C1) 		4 VAL A 161
MET A 191
ILE A 177
ASN A 179
 None
 0.90A 4a97G-1yalA:
undetectable		 4a97G-1yalA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cv6 SEED STORAGE PROTEIN

(Vigna radiata) 		PF00190
(Cupin_1) 		4 PHE A  41
TYR A  54
VAL A  56
ILE A 128
 None
 0.94A 4a97G-2cv6A:
undetectable		 4a97G-2cv6A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eaa 7S GLOBULIN-3

(Vigna angularis) 		PF00190
(Cupin_1) 		4 PHE A  47
TYR A  60
VAL A  62
ILE A 134
 None
 0.89A 4a97G-2eaaA:
undetectable		 4a97G-2eaaA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f6h MYOSIN-2

(Saccharomyces
cerevisiae) 		PF01843
(DIL) 		4 PHE X 168
TYR X 129
VAL X 125
ILE X 175
 None
 1.05A 4a97G-2f6hX:
1.7		 4a97G-2f6hX:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hnk SAM-DEPENDENT
O-METHYLTRANSFERASE

(Leptospira
interrogans) 		PF01596
(Methyltransf_3) 		4 PHE A 152
VAL A 225
ILE A 221
GLU A  66
 None
None
None
SAH  A2001 ( 4.2A)
 0.98A 4a97G-2hnkA:
undetectable		 4a97G-2hnkA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iuy GLYCOSYLTRANSFERASE

(Streptomyces
viridochromogenes) 		PF00534
(Glycos_transf_1) 		4 TYR A  39
VAL A 230
ILE A 227
GLU A 270
 None
MES  A1353 (-3.4A)
None
None
 1.04A 4a97G-2iuyA:
undetectable		 4a97G-2iuyA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qc7 ENDOPLASMIC
RETICULUM PROTEIN
ERP29

(Homo sapiens) 		PF07749
(ERp29)
PF07912
(ERp29_N) 		4 PHE A  46
VAL A  91
ILE A  93
ASN A 101
 None
 0.96A 4a97G-2qc7A:
1.7		 4a97G-2qc7A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qn0 NEUROTOXIN

(Clostridium
botulinum) 		PF01742
(Peptidase_M27) 		4 TYR A 202
VAL A 379
ILE A 256
GLU A 360
 None
 0.92A 4a97G-2qn0A:
undetectable		 4a97G-2qn0A:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r6f EXCINUCLEASE ABC
SUBUNIT A

(Geobacillus
stearothermophilus) 		PF00005
(ABC_tran) 		4 TYR A 315
VAL A 375
ILE A 376
ASN A 378
 None
 1.10A 4a97G-2r6fA:
undetectable		 4a97G-2r6fA:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yqu 2-OXOGLUTARATE
DEHYDROGENASE E3
COMPONENT

(Thermus
thermophilus) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 TYR A 265
VAL A 303
ILE A 284
GLU A  31
 FAD  A1601 (-4.8A)
None
None
FAD  A1601 (-2.7A)
 0.87A 4a97G-2yquA:
undetectable		 4a97G-2yquA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z3k LEUCYL/PHENYLALANYL-
TRNA-PROTEIN
TRANSFERASE

(Escherichia
coli) 		PF03588
(Leu_Phe_trans) 		4 TYR A  87
VAL A  89
MET A 144
ILE A 132
 None
None
PHE  A 302 ( 3.6A)
None
 0.80A 4a97G-2z3kA:
undetectable		 4a97G-2z3kA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zi8 PROBABLE
BIPHENYL-2,3-DIOL
1,2-DIOXYGENASE BPHC

(Mycobacterium
tuberculosis) 		PF00903
(Glyoxalase) 		4 PHE A 136
VAL A 218
MET A 257
ILE A 265
 None
 0.90A 4a97G-2zi8A:
undetectable		 4a97G-2zi8A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3al8 SEMAPHORIN-6A

(Mus musculus) 		PF01403
(Sema)
PF01437
(PSI) 		4 PHE A 291
TYR A 292
ILE A 295
ASN A 294
 None
 1.04A 4a97G-3al8A:
undetectable		 4a97G-3al8A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bm3 PSPGI RESTRICTION
ENDONUCLEASE

(Pyrococcus sp.
GI-H) 		PF09019
(EcoRII-C) 		4 PHE A 104
VAL A 159
ILE A 157
GLU A  60
 None
 1.04A 4a97G-3bm3A:
undetectable		 4a97G-3bm3A:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3doo SHIKIMATE
DEHYDROGENASE

(Staphylococcus
epidermidis) 		PF01488
(Shikimate_DH)
PF08501
(Shikimate_dh_N) 		4 TYR A  97
VAL A  84
ILE A  67
GLU A  76
 None
 1.00A 4a97G-3dooA:
undetectable		 4a97G-3dooA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ejg NON-STRUCTURAL
PROTEIN 3

(Human
coronavirus
229E) 		PF01661
(Macro) 		4 PHE A   6
TYR A  15
VAL A 150
ILE A 120
 None
 0.94A 4a97G-3ejgA:
undetectable		 4a97G-3ejgA:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eo6 PROTEIN OF UNKNOWN
FUNCTION (DUF1255)

(Acidithiobacillus
ferrooxidans) 		PF06865
(DUF1255) 		4 VAL A  59
MET A  83
ILE A  57
GLU A  97
 None
 1.06A 4a97G-3eo6A:
undetectable		 4a97G-3eo6A:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ewr NON-STRUCTURAL
PROTEIN 3

(Human
coronavirus
229E) 		PF01661
(Macro) 		4 PHE A   7
TYR A  16
VAL A 151
ILE A 121
 None
None
APR  A 169 ( 4.6A)
None
 0.90A 4a97G-3ewrA:
undetectable		 4a97G-3ewrA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eya PYRUVATE
DEHYDROGENASE
[CYTOCHROME]

(Escherichia
coli) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		4 TYR A 200
MET A 306
ILE A 289
GLU A 324
 None
 1.07A 4a97G-3eyaA:
undetectable		 4a97G-3eyaA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g0t PUTATIVE
AMINOTRANSFERASE

(Porphyromonas
gingivalis) 		PF00155
(Aminotran_1_2) 		4 TYR A 377
VAL A 375
MET A  48
ILE A 412
 None
 1.00A 4a97G-3g0tA:
undetectable		 4a97G-3g0tA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ib5 SEX PHEROMONE
PRECURSOR

(Lactobacillus
salivarius) 		PF07537
(CamS) 		4 TYR A 146
VAL A 147
MET A 227
ILE A 172
 None
 0.80A 4a97G-3ib5A:
undetectable		 4a97G-3ib5A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ihp UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 5

(Homo sapiens) 		PF00443
(UCH)
PF00627
(UBA)
PF02148
(zf-UBP) 		4 PHE A 461
TYR A 568
VAL A 570
ILE A 827
 None
 1.10A 4a97G-3ihpA:
undetectable		 4a97G-3ihpA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j82 C-TYPE LECTIN DOMAIN
FAMILY 9 MEMBER A

(Mus musculus) 		PF00059
(Lectin_C) 		4 TYR A 236
VAL A 198
MET A 181
ILE A 175
 None
 1.03A 4a97G-3j82A:
undetectable		 4a97G-3j82A:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k2k PUTATIVE
CARBOXYPEPTIDASE

(Burkholderia
mallei) 		PF00246
(Peptidase_M14) 		4 PHE A  84
VAL A  86
MET A  55
ILE A  97
 None
 1.08A 4a97G-3k2kA:
undetectable		 4a97G-3k2kA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kq0 ALPHA-1-ACID
GLYCOPROTEIN 1

(Homo sapiens) 		PF00061
(Lipocalin) 		4 PHE A  32
TYR A  37
VAL A  41
ILE A  44
 None
 1.08A 4a97G-3kq0A:
undetectable		 4a97G-3kq0A:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ltf PROTEIN SPITZ

(Drosophila
melanogaster) 		no annotation 4 PHE D  23
VAL D  25
ILE D  27
GLU D  36
 None
 1.01A 4a97G-3ltfD:
undetectable		 4a97G-3ltfD:
10.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ml6 CHIMERIC COMPLEX
BETWEEN PROTEIN
DISHEVLLED2 HOMOLOG
DVL-2 AND CLATHRIN
ADAPTOR AP-2 COMPLEX
SUBUNIT MU

(Mus musculus;
Rattus
norvegicus) 		PF00610
(DEP)
PF00928
(Adap_comp_sub) 		4 PHE A 469
TYR A 463
VAL A 466
MET A 430
 None
 1.01A 4a97G-3ml6A:
undetectable		 4a97G-3ml6A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nua PHOSPHORIBOSYLAMINOI
MIDAZOLE-SUCCINOCARB
OXAMIDE SYNTHASE

(Clostridium
perfringens) 		PF01259
(SAICAR_synt) 		4 TYR A 226
VAL A 229
ILE A 172
GLU A 193
 None
 1.09A 4a97G-3nuaA:
undetectable		 4a97G-3nuaA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p8s JACALIN

(Artocarpus
heterophyllus) 		PF01419
(Jacalin) 		4 PHE A 128
TYR A  95
VAL A 105
ILE A  49
 None
 1.04A 4a97G-3p8sA:
undetectable		 4a97G-3p8sA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pco PHENYLALANYL-TRNA
SYNTHETASE, BETA
CHAIN

(Escherichia
coli) 		PF01588
(tRNA_bind)
PF03147
(FDX-ACB)
PF03483
(B3_4)
PF03484
(B5) 		4 VAL B 250
ILE B 246
ASN B 254
GLU B 334
 None
 1.09A 4a97G-3pcoB:
undetectable		 4a97G-3pcoB:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pg7 NEUROFIBROMIN

(Homo sapiens) 		PF13716
(CRAL_TRIO_2) 		4 PHE A1719
VAL A1736
ILE A1805
GLU A1794
 None
 1.06A 4a97G-3pg7A:
undetectable		 4a97G-3pg7A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pm0 CYTOCHROME P450 1B1

(Homo sapiens) 		PF00067
(p450) 		4 TYR A 214
VAL A 199
ARG A 213
ASN A 203
 None
 1.07A 4a97G-3pm0A:
undetectable		 4a97G-3pm0A:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3um6 BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE

(Plasmodium
falciparum) 		PF00186
(DHFR_1)
PF00303
(Thymidylat_synt) 		4 VAL A 140
MET A 104
ILE A 126
ASN A 124
 None
1CY  A 609 ( 4.5A)
None
None
 0.82A 4a97G-3um6A:
undetectable		 4a97G-3um6A:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v9e LACCASE

(Botrytis aclada) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 PHE A 393
TYR A 397
VAL A 399
GLU A 390
 None
 1.02A 4a97G-3v9eA:
undetectable		 4a97G-3v9eA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vtz GLUCOSE
1-DEHYDROGENASE

(Thermoplasma
volcanium) 		PF13561
(adh_short_C2) 		4 TYR A 109
VAL A 105
ILE A 101
ASN A 106
 None
 0.87A 4a97G-3vtzA:
undetectable		 4a97G-3vtzA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wcy INTERFERON
ALPHA/BETA RECEPTOR
1

(Mus musculus) 		PF01108
(Tissue_fac)
PF09294
(Interfer-bind) 		4 TYR A 370
VAL A 372
MET A 352
ILE A 339
 None
 0.90A 4a97G-3wcyA:
undetectable		 4a97G-3wcyA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wiq KOJIBIOSE
PHOSPHORYLASE

(Caldicellulosiruptor
saccharolyticus) 		PF03632
(Glyco_hydro_65m)
PF03633
(Glyco_hydro_65C)
PF03636
(Glyco_hydro_65N) 		4 PHE A 655
VAL A 307
ILE A 311
ASN A 310
 None
 0.93A 4a97G-3wiqA:
1.6		 4a97G-3wiqA:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wr7 SPERMIDINE
N1-ACETYLTRANSFERASE

(Escherichia
coli) 		PF13302
(Acetyltransf_3) 		4 TYR A  30
VAL A 122
ILE A 130
ASN A 126
 COA  A 202 (-3.4A)
COA  A 202 ( 4.8A)
None
COA  A 202 ( 4.7A)
 1.07A 4a97G-3wr7A:
undetectable		 4a97G-3wr7A:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4akd MANNOSE-SPECIFIC
LECTIN KM+

(Artocarpus
integer) 		PF01419
(Jacalin) 		4 PHE A 121
TYR A  83
VAL A  97
ILE A  38
 None
 1.07A 4a97G-4akdA:
undetectable		 4a97G-4akdA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b6z FAMILY M14
UNASSIGNED PEPTIDASE

(Burkholderia
cenocepacia) 		PF00246
(Peptidase_M14) 		4 PHE A  84
VAL A  86
MET A  55
ILE A  97
 None
 1.08A 4a97G-4b6zA:
0.6		 4a97G-4b6zA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bih UNCHARACTERIZED
LIPOPROTEIN
SAOUHSC_00053

(Staphylococcus
aureus) 		PF04507
(DUF576) 		4 TYR A 125
VAL A 127
ILE A 134
GLU A 122
 None
 1.06A 4a97G-4bihA:
undetectable		 4a97G-4bihA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bwf UBIQUITIN-CONJUGATIN
G ENZYME E2-21 KDA

(Saccharomyces
cerevisiae) 		PF00179
(UQ_con) 		4 ARG A 177
ILE A 102
ASN A 101
GLU A  62
 None
 1.08A 4a97G-4bwfA:
undetectable		 4a97G-4bwfA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c8q DNA TOPOISOMERASE
2-ASSOCIATED PROTEIN
PAT1

(Saccharomyces
cerevisiae) 		PF09770
(PAT1) 		4 PHE H 681
VAL H 727
ILE H 724
GLU H 701
 None
None
None
CO  H1080 (-3.8A)
 1.09A 4a97G-4c8qH:
undetectable		 4a97G-4c8qH:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dpy MEVALONATE
DIPHOSPHATE
DECARBOXYLASE

(Staphylococcus
epidermidis) 		PF00288
(GHMP_kinases_N) 		4 TYR A 279
VAL A 290
ILE A 179
GLU A 269
 None
 0.92A 4a97G-4dpyA:
2.2		 4a97G-4dpyA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eg9 UNCHARACTERIZED
PROTEIN
SAOUHSC_02783

(Staphylococcus
aureus) 		PF04507
(DUF576) 		4 VAL A  95
ILE A  75
ASN A  77
GLU A 126
 None
 0.70A 4a97G-4eg9A:
undetectable		 4a97G-4eg9A:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fyc THIOL:DISULFIDE
INTERCHANGE PROTEIN
(DSBC)

(Helicobacter
pylori) 		PF13098
(Thioredoxin_2) 		4 PHE A  67
TYR A 116
VAL A  83
ILE A 158
 None
 0.96A 4a97G-4fycA:
undetectable		 4a97G-4fycA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jz7 CARBAMATE KINASE

(Giardia
intestinalis) 		PF00696
(AA_kinase) 		4 VAL A  49
MET A 233
ILE A   9
GLU A 106
 None
 1.05A 4a97G-4jz7A:
undetectable		 4a97G-4jz7A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p27 VENOM ALLERGEN-LIKE
(VAL) 4 PROTEIN

(Schistosoma
mansoni) 		PF00188
(CAP) 		4 PHE A  14
VAL A  18
ILE A  27
GLU A  85
 None
 1.00A 4a97G-4p27A:
undetectable		 4a97G-4p27A:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p68 DIHYDROFOLATE
REDUCTASE

(Escherichia
coli) 		PF00186
(DHFR_1) 		4 VAL A  72
MET A  42
ILE A  61
ASN A  59
 None
None
None
XCN  A  54 ( 3.0A)
 0.85A 4a97G-4p68A:
undetectable		 4a97G-4p68A:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q8k ALGINASE

(Pseudoalteromonas
sp. SM0524) 		PF08787
(Alginate_lyase2) 		4 PHE A 239
TYR A 395
VAL A 393
ILE A 175
 None
 1.03A 4a97G-4q8kA:
undetectable		 4a97G-4q8kA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q8l ALGINASE

(Pseudoalteromonas
sp. SM0524) 		PF08787
(Alginate_lyase2) 		4 PHE A  72
TYR A 228
VAL A 226
ILE A   8
 None
 1.02A 4a97G-4q8lA:
undetectable		 4a97G-4q8lA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qni UNCHARACTERIZED
PROTEIN

(Bacteroides
thetaiotaomicron) 		PF14274
(DUF4361)
PF16343
(DUF4973) 		4 TYR A 328
VAL A 330
ILE A 200
ASN A 202
 None
None
EDO  A 403 ( 4.1A)
EDO  A 403 ( 4.9A)
 1.02A 4a97G-4qniA:
undetectable		 4a97G-4qniA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rep GAMMA-CAROTENE
DESATURASE

(Nonlabens
dokdonensis) 		PF01593
(Amino_oxidase) 		4 VAL A 257
MET A 286
ILE A 250
GLU A 486
 None
 1.07A 4a97G-4repA:
undetectable		 4a97G-4repA:
20.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4twf CYS-LOOP
LIGAND-GATED ION
CHANNEL

(Dickeya
chrysanthemi) 		PF02931
(Neur_chan_LBD) 		6 PHE A  19
TYR A  38
VAL A  40
ARG A  91
MET A  93
ILE A 101
 None
 0.54A 4a97G-4twfA:
33.8		 4a97G-4twfA:
99.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4twf CYS-LOOP
LIGAND-GATED ION
CHANNEL

(Dickeya
chrysanthemi) 		PF02931
(Neur_chan_LBD) 		5 PHE A  19
VAL A  40
ARG A  91
MET A  93
ASN A 103
 None
 0.94A 4a97G-4twfA:
33.8		 4a97G-4twfA:
99.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4yeu CYS-LOOP
LIGAND-GATED ION
CHANNEL,PROTON-GATED
ION CHANNEL

(Dickeya
chrysanthemi;
Gloeobacter
violaceus) 		PF02931
(Neur_chan_LBD) 		7 PHE A  19
TYR A  38
VAL A  40
ARG A  91
MET A  93
ILE A 101
ASN A 103
 None
 0.61A 4a97G-4yeuA:
29.4		 4a97G-4yeuA:
71.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yke MRE11

(Chaetomium
thermophilum) 		PF00149
(Metallophos)
PF04152
(Mre11_DNA_bind) 		4 PHE A 390
VAL A 404
ILE A 368
GLU A 385
 None
 1.07A 4a97G-4ykeA:
undetectable		 4a97G-4ykeA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z81 EGF FAMILY
DOMAIN-CONTAINING
PROTEIN

(Toxoplasma
gondii) 		PF02430
(AMA-1)
PF07974
(EGF_2) 		4 PHE A 367
TYR A 368
VAL A 370
ILE A 154
 None
 1.07A 4a97G-4z81A:
undetectable		 4a97G-4z81A:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aee ALPHA-GLUCOSIDASE
YIHQ

(Escherichia
coli) 		PF01055
(Glyco_hydro_31) 		4 PHE A 530
VAL A 564
ARG A 560
ILE A 678
 None
 1.03A 4a97G-5aeeA:
undetectable		 4a97G-5aeeA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5awf FES CLUSTER ASSEMBLY
PROTEIN SUFB

(Escherichia
coli) 		PF01458
(UPF0051) 		4 PHE A 471
VAL A 346
MET A 408
ILE A 377
 None
 1.06A 4a97G-5awfA:
undetectable		 4a97G-5awfA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c5u PROLYL 4-HYDROXYLASE

(Paramecium
bursaria
Chlorella virus
1) 		PF13640
(2OG-FeII_Oxy_3) 		4 PHE A 104
VAL A 140
ILE A 232
GLU A 108
 None
 1.08A 4a97G-5c5uA:
undetectable		 4a97G-5c5uA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cmn LATROPHILIN-3

(Homo sapiens) 		PF02191
(OLF) 		4 PHE E 314
VAL E 367
ILE E 364
ASN E 312
 None
CA  E 401 (-4.8A)
None
CA  E 401 (-3.3A)
 1.02A 4a97G-5cmnE:
undetectable		 4a97G-5cmnE:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5czz CRISPR-ASSOCIATED
ENDONUCLEASE CAS9

(Staphylococcus
aureus) 		PF13395
(HNH_4)
PF16592
(Cas9_REC) 		4 ARG A 980
ILE A 982
ASN A 995
GLU A1006
 None
 1.07A 4a97G-5czzA:
3.0		 4a97G-5czzA:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dxv RETHREADED DHFR

(synthetic
construct) 		PF00186
(DHFR_1) 		4 VAL A  89
MET A  59
ILE A  78
ASN A  76
 None
 0.81A 4a97G-5dxvA:
undetectable		 4a97G-5dxvA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e9o CELLULASE, GLYCOSYL
HYDROLASE FAMILY 5,
TPS LINKER, DOMAIN X

(Spirochaeta
thermophila) 		no annotation 4 TYR A 526
ILE A 517
ASN A 503
GLU A 461
 None
 0.89A 4a97G-5e9oA:
undetectable		 4a97G-5e9oA:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5flz SPINDLE POLE BODY
COMPONENT SPC98

(Saccharomyces
cerevisiae) 		PF04130
(Spc97_Spc98) 		4 TYR B 187
VAL B 188
ILE B 224
GLU B 182
 None
 0.97A 4a97G-5flzB:
1.3		 4a97G-5flzB:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fno MANGANESE
LIPOXYGENASE

(Magnaporthe
oryzae) 		PF00305
(Lipoxygenase) 		4 VAL A 573
MET A 566
ILE A 569
GLU A 476
 None
 1.09A 4a97G-5fnoA:
undetectable		 4a97G-5fnoA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ii5 MALTOSE-BINDING
PERIPLASMIC
PROTEIN,VITELLINE
ENVELOPE SPERM LYSIN
RECEPTOR

(Escherichia
coli;
Haliotis
rufescens) 		PF11386
(VERL)
PF13416
(SBP_bac_8) 		4 PHE A4106
VAL A4123
MET A4077
ILE A4070
 None
 0.81A 4a97G-5ii5A:
undetectable		 4a97G-5ii5A:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l0l UNCHARACTERIZED
PROTEIN

(Legionella
pneumophila) 		no annotation 4 TYR A 130
VAL A 132
MET A 224
ILE A 144
 None
 0.77A 4a97G-5l0lA:
undetectable		 4a97G-5l0lA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mpd 26S PROTEASOME
REGULATORY SUBUNIT
RPN6

(Saccharomyces
cerevisiae) 		PF01399
(PCI) 		4 VAL Q 302
MET Q 271
ILE Q 270
GLU Q 322
 None
 0.82A 4a97G-5mpdQ:
2.2		 4a97G-5mpdQ:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n0l GTP-SENSING
TRANSCRIPTIONAL
PLEIOTROPIC
REPRESSOR CODY

(Clostridioides
difficile) 		no annotation 4 PHE A  74
TYR A  78
VAL A  82
ILE A  85
 ILE  A 201 ( 4.7A)
None
None
None
 1.02A 4a97G-5n0lA:
undetectable		 4a97G-5n0lA:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5te1 ATP-CITRATE SYNTHASE

(Homo sapiens) 		PF00549
(Ligase_CoA)
PF02629
(CoA_binding)
PF16114
(Citrate_bind) 		4 PHE A 493
VAL A 568
ILE A 591
GLU A 683
 None
 1.07A 4a97G-5te1A:
undetectable		 4a97G-5te1A:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tet ATP-CITRATE SYNTHASE

(Homo sapiens) 		PF00549
(Ligase_CoA)
PF02629
(CoA_binding) 		4 PHE B 493
VAL B 568
ILE B 591
GLU B 683
 None
 1.05A 4a97G-5tetB:
undetectable		 4a97G-5tetB:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5trv DENOVO NTF2

(synthetic
construct) 		PF12680
(SnoaL_2) 		5 PHE A  41
VAL A  36
MET A  88
ILE A 106
GLU A  46
 PEG  A 201 (-4.3A)
None
None
None
None
 1.34A 4a97G-5trvA:
undetectable		 4a97G-5trvA:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u7x NOD FACTOR BINDING
LECTIN-NUCLEOTIDE
PHOSPHOHYDROLASE

(Vigna
unguiculata) 		PF01150
(GDA1_CD39) 		4 TYR F 209
VAL F 164
ILE F 157
GLU F 185
 None
 1.06A 4a97G-5u7xF:
undetectable		 4a97G-5u7xF:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5udy ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 7

(Homo sapiens) 		PF01663
(Phosphodiest) 		4 TYR A 194
VAL A  36
ILE A 243
GLU A 171
 None
None
None
FUC  A 508 ( 4.3A)
 1.00A 4a97G-5udyA:
undetectable		 4a97G-5udyA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uwb TOLUENE TOLERANCE
PROTEIN

(Pseudomonas
putida) 		no annotation 4 TYR B 144
VAL B 164
ILE B 167
ASN B 165
 PEF  B 302 (-4.0A)
PEF  B 302 ( 4.6A)
None
PEF  B 302 ( 4.1A)
 0.95A 4a97G-5uwbB:
undetectable		 4a97G-5uwbB:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vf3 MAJOR CAPSID PROTEIN

(Escherichia
virus T4) 		PF07068
(Gp23) 		4 PHE A 434
VAL A 382
ILE A 521
GLU A 360
 None
 1.08A 4a97G-5vf3A:
undetectable		 4a97G-5vf3A:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xns CHROMOSOME PARTITION
PROTEIN SMC

(Pyrococcus
furiosus) 		PF02463
(SMC_N) 		4 PHE A  12
TYR A  15
VAL A  82
ILE A  84
 None
 1.01A 4a97G-5xnsA:
undetectable		 4a97G-5xnsA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yfb DIPEPTIDYL PEPTIDASE
3

(Armillaria
tabescens) 		no annotation 4 TYR A 313
VAL A 314
ILE A 164
GLU A 324
 None
 1.01A 4a97G-5yfbA:
undetectable		 4a97G-5yfbA:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d46 BETA SLIDING CLAMP

(Rickettsia
typhi) 		no annotation 4 PHE A 353
TYR A 352
VAL A 362
ILE A 376
 None
 0.98A 4a97G-6d46A:
undetectable		 4a97G-6d46A:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f36 MITOCHONDRIAL ATP
SYNTHASE SUBUNIT
ASA6

(Polytomella sp.
Pringsheim
198.80) 		no annotation 4 PHE N 129
TYR N 126
VAL N 125
ILE N 120
 None
 1.06A 4a97G-6f36N:
undetectable		 4a97G-6f36N:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cyq INTRON-ENCODED
HOMING ENDONUCLEASE
I-PPOI

(Physarum
polycephalum) 		no annotation 4 GLU A  16
ILE A  12
VAL A 136
PHE A  82
 None
 0.97A 4a97H-1cyqA:
undetectable		 4a97H-1cyqA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e1c METHYLMALONYL-COA
MUTASE ALPHA CHAIN

(Propionibacterium
freudenreichii) 		PF01642
(MM_CoA_mutase)
PF02310
(B12-binding) 		4 GLU A 447
ILE A 566
GLU A 448
VAL A 427
 None
 1.05A 4a97H-1e1cA:
0.0		 4a97H-1e1cA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gpp ENDONUCLEASE PI-SCEI

(Saccharomyces
cerevisiae) 		PF05203
(Hom_end_hint) 		4 ILE A  21
HIS A 442
VAL A  82
PHE A   2
 None
 0.83A 4a97H-1gppA:
undetectable		 4a97H-1gppA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jov HI1317

(Haemophilus
influenzae) 		PF01263
(Aldose_epim) 		4 ILE A  75
HIS A 134
VAL A 108
PHE A 112
 None
 1.10A 4a97H-1jovA:
undetectable		 4a97H-1jovA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jqp DIPEPTIDYL PEPTIDASE
I

(Rattus
norvegicus) 		PF00112
(Peptidase_C1)
PF08773
(CathepsinC_exc) 		4 GLU A  84
TYR A  93
HIS A  95
VAL A 114
 None
 1.08A 4a97H-1jqpA:
0.0		 4a97H-1jqpA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rtr GERANYLTRANSTRANSFER
ASE

(Staphylococcus
aureus) 		PF00348
(polyprenyl_synt) 		4 GLU A 201
GLU A 204
HIS A 261
VAL A 285
 None
 1.06A 4a97H-1rtrA:
undetectable		 4a97H-1rtrA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sus CAFFEOYL-COA
O-METHYLTRANSFERASE

(Medicago sativa) 		PF01596
(Methyltransf_3) 		4 GLU A  85
ILE A 107
HIS A  43
VAL A  38
 SAH  A 301 (-4.1A)
None
None
None
 1.05A 4a97H-1susA:
0.0		 4a97H-1susA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1um2 ENDONUCLEASE PI-SCEI

(Saccharomyces
cerevisiae) 		PF05203
(Hom_end_hint)
PF05204
(Hom_end) 		4 ILE A 304
HIS A 725
VAL A 365
PHE A 285
 None
 1.03A 4a97H-1um2A:
undetectable		 4a97H-1um2A:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wst MULTIPLE SUBSTRATE
AMINOTRANSFERASE

(Thermococcus
profundus) 		PF00155
(Aminotran_1_2) 		4 GLU A 227
TYR A 100
HIS A 240
VAL A 107
 None
 1.12A 4a97H-1wstA:
0.0		 4a97H-1wstA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wst MULTIPLE SUBSTRATE
AMINOTRANSFERASE

(Thermococcus
profundus) 		PF00155
(Aminotran_1_2) 		4 GLU A 227
TYR A 100
HIS A 240
VAL A 247
 None
 1.08A 4a97H-1wstA:
0.0		 4a97H-1wstA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xec DECORIN

(Bos taurus) 		PF01462
(LRRNT)
PF13855
(LRR_8) 		4 ILE A 265
HIS A 271
VAL A 305
PHE A 283
 None
 1.11A 4a97H-1xecA:
0.0		 4a97H-1xecA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xmb IAA-AMINO ACID
HYDROLASE HOMOLOG 2

(Arabidopsis
thaliana) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		4 ILE A  54
HIS A 154
VAL A 164
PHE A 168
 None
 1.02A 4a97H-1xmbA:
undetectable		 4a97H-1xmbA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xr0 FGFR SIGNALLING
ADAPTOR SNT-1

(Homo sapiens) 		PF02174
(IRS) 		4 GLU B  44
ILE B  46
GLU B  39
VAL B  13
 None
 1.07A 4a97H-1xr0B:
undetectable		 4a97H-1xr0B:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y63 LMAJ004144AAA
PROTEIN

(Leishmania
major) 		PF13238
(AAA_18) 		4 GLU A  69
ILE A  64
TYR A  90
VAL A 104
 None
None
MN  A 356 ( 4.7A)
None
 0.95A 4a97H-1y63A:
undetectable		 4a97H-1y63A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ygu LEUKOCYTE COMMON
ANTIGEN

(Homo sapiens) 		PF00102
(Y_phosphatase) 		4 GLU A 894
GLU A1167
TYR A 767
VAL A 722
 None
 0.80A 4a97H-1yguA:
undetectable		 4a97H-1yguA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z1w TRICORN PROTEASE
INTERACTING FACTOR
F3

(Thermoplasma
acidophilum) 		PF01433
(Peptidase_M1)
PF11838
(ERAP1_C) 		4 ILE A 548
TYR A 529
VAL A 771
PHE A 516
 None
 1.10A 4a97H-1z1wA:
1.0		 4a97H-1z1wA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z7z HUMAN COXSACKIEVIRUS
A21

(Enterovirus C) 		PF00073
(Rhv) 		4 ILE 1 248
GLU 1 135
TYR 1 150
VAL 1 254
 None
 1.11A 4a97H-1z7z1:
undetectable		 4a97H-1z7z1:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zjc AMINOPEPTIDASE AMPS

(Staphylococcus
aureus) 		PF02073
(Peptidase_M29) 		4 GLU A 343
GLU A 319
TYR A 355
PHE A 255
 CO  A 503 (-2.2A)
CO  A 501 ( 2.6A)
CO  A 502 (-4.9A)
CO  A 501 ( 4.9A)
 1.07A 4a97H-1zjcA:
undetectable		 4a97H-1zjcA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h8r HEPATOCYTE NUCLEAR
FACTOR 1-BETA

(Homo sapiens) 		PF00046
(Homeobox)
PF04814
(HNF-1_N) 		4 GLU A 138
GLU A 178
HIS A 284
VAL A 278
 None
 0.87A 4a97H-2h8rA:
undetectable		 4a97H-2h8rA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ifa HYPOTHETICAL PROTEIN
SMU.260

(Streptococcus
mutans) 		PF00881
(Nitroreductase) 		4 ILE A  36
HIS A 149
VAL A 154
PHE A  99
 None
FMN  A 501 (-4.1A)
None
None
 1.11A 4a97H-2ifaA:
undetectable		 4a97H-2ifaA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ke9 CASKIN-2

(Homo sapiens) 		PF07653
(SH3_2) 		4 ILE A 334
HIS A 325
VAL A 344
PHE A 337
 None
 1.10A 4a97H-2ke9A:
undetectable		 4a97H-2ke9A:
12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nna MHC CLASS II ANTIGEN

(Homo sapiens) 		PF00969
(MHC_II_beta)
PF07654
(C1-set) 		4 GLU B  36
ILE B  31
VAL B  78
PHE B  11
 None
 1.03A 4a97H-2nnaB:
2.4		 4a97H-2nnaB:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o3j UDP-GLUCOSE
6-DEHYDROGENASE

(Caenorhabditis
elegans) 		PF00984
(UDPG_MGDP_dh)
PF03720
(UDPG_MGDP_dh_C)
PF03721
(UDPG_MGDP_dh_N) 		4 GLU A 249
ILE A 465
HIS A 363
PHE A 444
 None
 1.04A 4a97H-2o3jA:
undetectable		 4a97H-2o3jA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r50 NON-SYMBIOTIC
HEMOGLOBIN

(Zea mays) 		PF00042
(Globin) 		4 GLU A 127
HIS A 117
VAL A 154
PHE A  39
 None
None
HEM  A 166 ( 4.5A)
None
 1.04A 4a97H-2r50A:
undetectable		 4a97H-2r50A:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rhq PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN

(Staphylococcus
haemolyticus) 		PF01409
(tRNA-synt_2d) 		4 GLU A 118
GLU A 347
TYR A 324
VAL A 277
 None
 0.98A 4a97H-2rhqA:
undetectable		 4a97H-2rhqA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wmo DEDICATOR OF
CYTOKINESIS PROTEIN
9

(Homo sapiens) 		PF06920
(DHR-2) 		4 TYR A 155
HIS A 229
VAL A 158
PHE A 287
 None
 0.84A 4a97H-2wmoA:
1.3		 4a97H-2wmoA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xss CGMP-SPECIFIC 3',
5'-CYCLIC
PHOSPHODIESTERASE

(Homo sapiens) 		PF01590
(GAF) 		4 GLU A 390
GLU A 392
TYR A 409
VAL A 415
 None
 1.11A 4a97H-2xssA:
undetectable		 4a97H-2xssA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yet GH61 ISOZYME A

(Thermoascus
aurantiacus) 		PF03443
(Glyco_hydro_61) 		4 ILE A  91
GLU A 159
TYR A 200
HIS A 201
 None
 1.01A 4a97H-2yetA:
undetectable		 4a97H-2yetA:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3adf MONOMERIC AZAMI
GREEN

(Galaxea
fascicularis) 		PF01353
(GFP) 		4 GLU A 144
TYR A 177
HIS A  88
VAL A 183
 None
 1.02A 4a97H-3adfA:
undetectable		 4a97H-3adfA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dec BETA-GALACTOSIDASE

(Bacteroides
thetaiotaomicron) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF02929
(Bgal_small_N)
PF16353
(DUF4981) 		4 GLU A 335
TYR A 238
HIS A 237
VAL A 297
 None
 0.99A 4a97H-3decA:
1.0		 4a97H-3decA:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dv8 TRANSCRIPTIONAL
REGULATOR, CRP/FNR
FAMILY

([Eubacterium]
rectale) 		PF00027
(cNMP_binding)
PF13545
(HTH_Crp_2) 		4 ILE A  35
GLU A  95
TYR A  57
VAL A 135
 None
 1.04A 4a97H-3dv8A:
undetectable		 4a97H-3dv8A:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e4c CASPASE-1

(Homo sapiens) 		PF00656
(Peptidase_C14) 		4 ILE A 328
HIS A 356
VAL A 133
PHE A 231
 None
 1.01A 4a97H-3e4cA:
undetectable		 4a97H-3e4cA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fdb PUTATIVE
PLP-DEPENDENT
BETA-CYSTATHIONASE

(Corynebacterium
diphtheriae) 		PF00155
(Aminotran_1_2) 		4 ILE A 235
HIS A 191
VAL A 279
PHE A  69
 None
LLP  A 222 ( 4.0A)
EDO  A 384 (-4.6A)
None
 1.03A 4a97H-3fdbA:
undetectable		 4a97H-3fdbA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gyu NUCLEAR HORMONE
RECEPTOR OF THE
STEROID/THYROID
HORMONE RECEPTORS
SUPERFAMILY

(Strongyloides
stercoralis) 		PF00104
(Hormone_recep) 		4 ILE A 633
HIS A 643
VAL A 601
PHE A 626
 None
 1.10A 4a97H-3gyuA:
undetectable		 4a97H-3gyuA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i12 D-ALANINE-D-ALANINE
LIGASE A

(Salmonella
enterica) 		PF01820
(Dala_Dala_lig_N)
PF07478
(Dala_Dala_lig_C) 		5 GLU A 230
ILE A 247
GLU A 228
VAL A 219
PHE A 304
 None
None
ADP  A 365 (-2.9A)
None
ADP  A 365 (-4.3A)
 1.25A 4a97H-3i12A:
undetectable		 4a97H-3i12A:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k55 BETA-HEMOLYSIN

(Staphylococcus
aureus) 		PF03372
(Exo_endo_phos) 		4 ILE A 183
TYR A 134
HIS A 116
VAL A 102
 None
 0.98A 4a97H-3k55A:
undetectable		 4a97H-3k55A:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n3u ADENOSINE
MONOPHOSPHATE-PROTEI
N TRANSFERASE IBPA

(Histophilus
somni) 		PF02661
(Fic) 		4 GLU A3751
TYR A3710
VAL A3704
PHE A3746
 None
 1.11A 4a97H-3n3uA:
undetectable		 4a97H-3n3uA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3odw RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 1

(Homo sapiens) 		PF00621
(RhoGEF) 		4 GLU A 428
TYR A 568
VAL A 588
PHE A 474
 None
 1.06A 4a97H-3odwA:
undetectable		 4a97H-3odwA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pf7 BENZOYL-COA
OXYGENASE COMPONENT
B

(Azoarcus
evansii) 		no annotation 4 ILE A 324
GLU A 321
TYR A 311
PHE A  89
 None
 1.01A 4a97H-3pf7A:
undetectable		 4a97H-3pf7A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q6t 43.2 KDA SALIVARY
PROTEIN

(Lutzomyia
longipalpis) 		PF03022
(MRJP) 		4 GLU A  57
TYR A 135
VAL A 138
PHE A  77
 None
 1.06A 4a97H-3q6tA:
undetectable		 4a97H-3q6tA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qky OUTER MEMBRANE
ASSEMBLY LIPOPROTEIN
YFIO

(Rhodothermus
marinus) 		PF13525
(YfiO) 		4 ILE A  98
GLU A 111
TYR A 146
PHE A 142
 None
 0.86A 4a97H-3qkyA:
undetectable		 4a97H-3qkyA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rnl SULFOTRANSFERASE

(Alicyclobacillus
acidocaldarius) 		PF13469
(Sulfotransfer_3) 		4 GLU A  85
TYR A  90
VAL A 174
PHE A   9
 None
 1.04A 4a97H-3rnlA:
undetectable		 4a97H-3rnlA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3va7 KLLA0E08119P

(Kluyveromyces
lactis) 		PF00289
(Biotin_carb_N)
PF00364
(Biotin_lipoyl)
PF02626
(CT_A_B)
PF02682
(CT_C_D)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 ILE A1508
GLU A1505
TYR A1445
VAL A1323
 None
 1.11A 4a97H-3va7A:
undetectable		 4a97H-3va7A:
12.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vrd FLAVOCYTOCHROME C
FLAVIN SUBUNIT

(Thermochromatium
tepidum) 		PF07992
(Pyr_redox_2)
PF09242
(FCSD-flav_bind) 		4 GLU B 167
ILE B 340
GLU B  47
VAL B  60
 None
 0.90A 4a97H-3vrdB:
undetectable		 4a97H-3vrdB:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w1g DNA LIGASE 4

(Homo sapiens) 		PF01068
(DNA_ligase_A_M)
PF04675
(DNA_ligase_A_N)
PF04679
(DNA_ligase_A_C) 		4 ILE A 315
TYR A 290
HIS A 282
PHE A 302
 None
 1.11A 4a97H-3w1gA:
undetectable		 4a97H-3w1gA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zvu ABSCISIC ACID
RECEPTOR PYR1

(Arabidopsis
thaliana) 		PF10604
(Polyketide_cyc2) 		4 GLU A  94
ILE A 110
HIS A  34
VAL A 139
 None
A8S  A 192 (-4.6A)
None
None
 0.90A 4a97H-3zvuA:
undetectable		 4a97H-3zvuA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4atq 4-AMINOBUTYRATE
TRANSAMINASE

(Paenarthrobacter
aurescens) 		PF00202
(Aminotran_3) 		4 GLU A 200
ILE A 205
VAL A 155
PHE A 248
 None
 1.08A 4a97H-4atqA:
undetectable		 4a97H-4atqA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4avx HEPATOCYTE GROWTH
FACTOR-REGULATED
TYROSINE KINASE
SUBSTRATE

(Homo sapiens) 		PF00790
(VHS)
PF01363
(FYVE) 		4 GLU A   9
TYR A  44
VAL A  79
PHE A   8
 None
EDO  A1234 (-4.1A)
None
None
 1.10A 4a97H-4avxA:
undetectable		 4a97H-4avxA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eis POLYSACCHARIDE
MONOOXYGENASE-3

(Neurospora
crassa) 		PF03443
(Glyco_hydro_61) 		4 ILE B  87
GLU B 155
TYR B 198
PHE B 170
 None
 0.80A 4a97H-4eisB:
undetectable		 4a97H-4eisB:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eyu LYSINE-SPECIFIC
DEMETHYLASE 6B

(Mus musculus) 		PF02373
(JmjC) 		4 GLU A1625
GLU A1626
TYR A1563
VAL A1618
 None
 1.00A 4a97H-4eyuA:
undetectable		 4a97H-4eyuA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f2a CHOLESTERYL ESTER
TRANSFER PROTEIN

(Homo sapiens) 		PF01273
(LBP_BPI_CETP)
PF02886
(LBP_BPI_CETP_C) 		4 ILE A 367
GLU A 365
VAL A 311
PHE A 363
 2OB  A 606 (-4.7A)
None
None
None
 1.07A 4a97H-4f2aA:
undetectable		 4a97H-4f2aA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f2a CHOLESTERYL ESTER
TRANSFER PROTEIN

(Homo sapiens) 		PF01273
(LBP_BPI_CETP)
PF02886
(LBP_BPI_CETP_C) 		4 ILE A 389
GLU A 365
VAL A 311
PHE A 363
 None
 0.98A 4a97H-4f2aA:
undetectable		 4a97H-4f2aA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gnx PUTATIVE
UNCHARACTERIZED
PROTEIN

(Ustilago maydis) 		PF01336
(tRNA_anti-codon) 		4 ILE B 154
GLU B 158
HIS B 149
VAL B 107
 None
 0.89A 4a97H-4gnxB:
undetectable		 4a97H-4gnxB:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gvl TRKA DOMAIN PROTEIN

(Geobacter
sulfurreducens) 		PF02080
(TrkA_C)
PF02254
(TrkA_N) 		4 ILE A 268
GLU A 279
TYR A 254
VAL A 442
 None
 1.06A 4a97H-4gvlA:
undetectable		 4a97H-4gvlA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hfu HEMAGGLUTININ HA1

(Influenza A
virus) 		PF00509
(Hemagglutinin) 		4 ILE A 179
HIS A 184
VAL A 223
PHE A 148
 None
 1.11A 4a97H-4hfuA:
undetectable		 4a97H-4hfuA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hh1 APPA PROTEIN

(Rhodobacter
sphaeroides) 		PF04940
(BLUF) 		4 GLU A  94
ILE A  96
GLU A  66
PHE A 101
 None
 0.94A 4a97H-4hh1A:
undetectable		 4a97H-4hh1A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i3g BETA-GLUCOSIDASE

(Streptomyces
venezuelae) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		4 ILE A 155
GLU A 169
VAL A 746
PHE A 705
 None
 1.08A 4a97H-4i3gA:
undetectable		 4a97H-4i3gA:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4icq AMINOPEPTIDASE PEPS

(Streptococcus
pneumoniae) 		PF02073
(Peptidase_M29) 		4 GLU A 343
GLU A 319
TYR A 355
PHE A 255
 ZN  A 502 ( 4.2A)
ZN  A 502 ( 2.5A)
ZN  A 501 (-4.8A)
None
 1.06A 4a97H-4icqA:
undetectable		 4a97H-4icqA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l3a INTERNALIN K

(Listeria
monocytogenes) 		no annotation 4 ILE A 298
TYR A 321
VAL A 357
PHE A 284
 None
 1.07A 4a97H-4l3aA:
undetectable		 4a97H-4l3aA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mt1 DRUG EFFLUX PROTEIN

(Neisseria
gonorrhoeae) 		PF00873
(ACR_tran) 		4 ILE A 982
TYR A 524
HIS A 522
PHE A1027
 None
 1.06A 4a97H-4mt1A:
0.0		 4a97H-4mt1A:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mt4 CMEC

(Campylobacter
jejuni) 		PF02321
(OEP) 		4 GLU A 145
ILE A 460
GLU A 149
PHE A 450
 None
 0.98A 4a97H-4mt4A:
0.0		 4a97H-4mt4A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nzr PGT135 HEAVY CHAIN
PROTEIN M TD

(Homo sapiens;
Mycoplasma
genitalium) 		PF07654
(C1-set)
PF07686
(V-set)
no annotation 		4 GLU M 427
ILE M 449
TYR H  32
HIS H  95
 None
 0.72A 4a97H-4nzrM:
undetectable		 4a97H-4nzrM:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pxl CYTOSOLIC ALDEHYDE
DEHYDROGENASE RF2C

(Zea mays) 		PF00171
(Aldedh) 		5 ILE A 123
TYR A 205
HIS A 207
VAL A 214
PHE A 177
 None
 1.36A 4a97H-4pxlA:
undetectable		 4a97H-4pxlA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qlp ALANINE AND PROLINE
RICH PROTEIN,
TUBERCULOSIS
NECROTIZING TOXIN
(TNT)

(Mycobacterium
tuberculosis) 		PF14021
(TNT) 		4 ILE B 739
TYR B 751
HIS B 771
PHE B 747
 None
 0.94A 4a97H-4qlpB:
undetectable		 4a97H-4qlpB:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r1k UNCHARACTERIZED
PROTEIN

([Eubacterium]
siraeum) 		PF17117
(DUF5104) 		4 GLU A  72
ILE A 159
TYR A  57
PHE A  54
 None
 0.97A 4a97H-4r1kA:
undetectable		 4a97H-4r1kA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r4g PUTATIVE LIPOPROTEIN
YCDA

(Bacillus
subtilis) 		PF11611
(DUF4352)
PF17118
(DUF5105) 		4 GLU A 354
ILE A 352
TYR A 307
VAL A 300
 None
 1.07A 4a97H-4r4gA:
undetectable		 4a97H-4r4gA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rhh BETA-XYLOSIDASE

(Geobacillus
stearothermophilus) 		PF03512
(Glyco_hydro_52) 		4 GLU A 354
TYR A 316
HIS A  10
VAL A 102
 None
 1.12A 4a97H-4rhhA:
0.7		 4a97H-4rhhA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rs2 PREDICTED
ACYLTRANSFERASE WITH
ACYL-COA
N-ACYLTRANSFERASE
DOMAIN

(Escherichia
coli) 		PF13508
(Acetyltransf_7) 		4 ILE A  14
GLU A   6
HIS A 163
VAL A  62
 None
 0.96A 4a97H-4rs2A:
undetectable		 4a97H-4rs2A:
20.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4twf CYS-LOOP
LIGAND-GATED ION
CHANNEL

(Dickeya
chrysanthemi) 		PF02931
(Neur_chan_LBD) 		5 GLU A  77
ILE A  79
GLU A 131
TYR A 175
PHE A 188
 BR7  A 401 ( 4.9A)
None
BR7  A 401 (-4.1A)
BR7  A 401 (-3.9A)
BR7  A 401 (-3.9A)
 0.45A 4a97H-4twfA:
33.9		 4a97H-4twfA:
99.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4twf CYS-LOOP
LIGAND-GATED ION
CHANNEL

(Dickeya
chrysanthemi) 		PF02931
(Neur_chan_LBD) 		4 GLU A 131
TYR A 175
VAL A 181
PHE A 188
 BR7  A 401 (-4.1A)
BR7  A 401 (-3.9A)
None
BR7  A 401 (-3.9A)
 1.06A 4a97H-4twfA:
33.9		 4a97H-4twfA:
99.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u10 POLY-BETA-1,6-N-ACET
YL-D-GLUCOSAMINE
N-DEACETYLASE

(Aggregatibacter
actinomycetemcomitans) 		PF01522
(Polysacc_deac_1) 		4 ILE A 283
TYR A  33
HIS A  34
VAL A  37
 None
None
ZN  A 402 ( 3.3A)
None
 1.10A 4a97H-4u10A:
undetectable		 4a97H-4u10A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wgg DOUBLE BOND
REDUCTASE

(Zingiber
officinale) 		PF00107
(ADH_zinc_N)
PF16884
(ADH_N_2) 		4 GLU A 236
ILE A 256
HIS A 248
PHE A 165
 None
 1.01A 4a97H-4wggA:
undetectable		 4a97H-4wggA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x0q DNA POLYMERASE THETA

(Homo sapiens) 		PF00476
(DNA_pol_A) 		4 GLU A2049
ILE A2053
HIS A2236
VAL A2232
 None
None
None
GOL  A2602 (-4.5A)
 0.94A 4a97H-4x0qA:
0.0		 4a97H-4x0qA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xf7 CARBOHYDRATE/PYRIMID
INE KINASE, PFKB
FAMILY

(Thermococcus
kodakarensis) 		no annotation 4 GLU A 169
ILE A 139
HIS A   8
VAL A   5
 MG  A 303 ( 4.0A)
None
None
None
 1.11A 4a97H-4xf7A:
undetectable		 4a97H-4xf7A:
21.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4yeu CYS-LOOP
LIGAND-GATED ION
CHANNEL,PROTON-GATED
ION CHANNEL

(Dickeya
chrysanthemi;
Gloeobacter
violaceus) 		PF02931
(Neur_chan_LBD) 		6 GLU A  77
ILE A  79
GLU A 131
TYR A 175
HIS A 177
PHE A 188
 None
 0.72A 4a97H-4yeuA:
29.4		 4a97H-4yeuA:
71.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5af3 VAPBC49

(Mycobacterium
tuberculosis) 		PF04255
(DUF433) 		4 ILE A 173
HIS A 106
VAL A 103
PHE A 164
 None
 1.10A 4a97H-5af3A:
undetectable		 4a97H-5af3A:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5evl BETA-LACTAMASE

(Chromobacterium
violaceum) 		PF00144
(Beta-lactamase) 		4 GLU A 176
ILE A 190
VAL A 337
PHE A  70
 None
 1.01A 4a97H-5evlA:
undetectable		 4a97H-5evlA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fwm HEAT SHOCK PROTEIN
HSP 90 BETA

(Homo sapiens) 		PF00183
(HSP90)
PF02518
(HATPase_c) 		4 ILE A 441
TYR A 457
HIS A 458
VAL A 494
 None
 1.10A 4a97H-5fwmA:
undetectable		 4a97H-5fwmA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i8i UREA AMIDOLYASE

(Kluyveromyces
lactis) 		PF00289
(Biotin_carb_N)
PF01425
(Amidase)
PF02626
(CT_A_B)
PF02682
(CT_C_D)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 ILE A1508
GLU A1505
TYR A1445
VAL A1323
 None
 1.09A 4a97H-5i8iA:
undetectable		 4a97H-5i8iA:
10.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kwl VP3

(Enterovirus C) 		PF00073
(Rhv) 		4 ILE 3  82
HIS 3 153
VAL 3 168
PHE 3 118
 None
 1.08A 4a97H-5kwl3:
undetectable		 4a97H-5kwl3:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ll1 URICASE

(Danio rerio) 		PF01014
(Uricase) 		4 GLU A  83
ILE A  82
VAL A 188
PHE A 135
 None
 0.86A 4a97H-5ll1A:
undetectable		 4a97H-5ll1A:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m9o STAPHYLOCOCCAL
NUCLEASE
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF00565
(SNase)
PF00567
(TUDOR) 		4 GLU A 751
HIS A 695
VAL A 698
PHE A 762
 None
 1.07A 4a97H-5m9oA:
undetectable		 4a97H-5m9oA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ojj UBIQUITIN-CONJUGATIN
G ENZYME E2 T

(Homo sapiens) 		PF00179
(UQ_con) 		4 GLU A 131
TYR A  75
HIS A 150
PHE A 139
 None
 1.08A 4a97H-5ojjA:
undetectable		 4a97H-5ojjA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5td7 ZGC:55652

(Danio rerio) 		PF00850
(Hist_deacetyl) 		4 GLU A  28
TYR A  16
HIS A 103
VAL A  74
 None
 1.09A 4a97H-5td7A:
undetectable		 4a97H-5td7A:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tkf LYTIC POLYSACCHARIDE
MONOOXYGENASE

(Neurospora
crassa) 		PF03443
(Glyco_hydro_61) 		4 ILE A  89
GLU A 152
TYR A 194
PHE A 167
 None
 0.63A 4a97H-5tkfA:
undetectable		 4a97H-5tkfA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u4r VRC 315 53-1A09 FAB
HEAVY CHAIN

(Homo sapiens) 		no annotation 4 TYR A  32
HIS A  33
VAL A  78
PHE A  27
 None
 0.97A 4a97H-5u4rA:
undetectable		 4a97H-5u4rA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v9x ATP-DEPENDENT DNA
HELICASE

(Mycolicibacterium
smegmatis) 		no annotation 4 GLU A 558
GLU A 554
HIS A 689
VAL A 817
 None
 1.11A 4a97H-5v9xA:
undetectable		 4a97H-5v9xA:
13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w21 FIBROBLAST GROWTH
FACTOR 23

(Homo sapiens) 		no annotation 4 ILE B  75
TYR B 127
HIS B 128
PHE B 157
 None
 1.06A 4a97H-5w21B:
undetectable		 4a97H-5w21B:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xgz BETA-GLYCOSIDASE

(uncultured
microorganism) 		no annotation 4 GLU A 410
HIS A  61
VAL A  29
PHE A 415
 GOL  A 501 ( 2.7A)
None
None
GOL  A 506 (-3.7A)
 0.98A 4a97H-5xgzA:
undetectable		 4a97H-5xgzA:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xhw PUTATIVE
6-DEOXY-D-MANNOHEPTO
SE PATHWAY PROTEIN

(Yersinia
pseudotuberculosis) 		no annotation 4 ILE A 154
GLU A 188
TYR A 170
PHE A 187
 None
SO4  A 303 ( 4.7A)
None
None
 1.09A 4a97H-5xhwA:
undetectable		 4a97H-5xhwA:
12.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xl2 HEMAGGLUTININ

(Influenza A
virus) 		PF00509
(Hemagglutinin) 		4 ILE A 176
HIS A 181
VAL A 220
PHE A 144
 None
 1.06A 4a97H-5xl2A:
undetectable		 4a97H-5xl2A:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xl6 HEMAGGLUTININ

(Influenza A
virus) 		PF00509
(Hemagglutinin) 		4 ILE A 176
HIS A 181
VAL A 220
PHE A 144
 None
 1.04A 4a97H-5xl6A:
undetectable		 4a97H-5xl6A:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y9q CARBON CATABOLITE
RESPONSIVE REGULATOR

(Staphylococcus
aureus) 		PF03466
(LysR_substrate) 		4 ILE A  99
GLU A  91
TYR A 114
VAL A  84
 None
 1.09A 4a97H-5y9qA:
undetectable		 4a97H-5y9qA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z7h LYSR FAMILY
TRANSCRIPTIONAL
REGULATOR

(Staphylococcus
aureus) 		no annotation 4 ILE A 189
GLU A 181
TYR A 204
VAL A 174
 None
 1.00A 4a97H-5z7hA:
undetectable		 4a97H-5z7hA:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6arx ACETYLCHOLINESTERASE

(Anopheles
gambiae) 		no annotation 4 GLU A 400
GLU A 448
TYR A 522
VAL A 694
 None
 1.04A 4a97H-6arxA:
undetectable		 4a97H-6arxA:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bpc RETICULOCYTE BINDING
PROTEIN 2, PUTATIVE

(Plasmodium
vivax) 		no annotation 4 GLU A 255
ILE A 251
GLU A 380
TYR A 177
 None
 0.64A 4a97H-6bpcA:
1.5		 4a97H-6bpcA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d04 RETICULOCYTE BINDING
PROTEIN 2, PUTATIVE

(Plasmodium
vivax) 		no annotation 4 GLU E 255
ILE E 251
GLU E 380
TYR E 177
 None
 0.95A 4a97H-6d04E:
undetectable		 4a97H-6d04E:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d6v TELOMERASE-ASSOCIATE
D PROTEIN 82

(Tetrahymena
thermophila) 		no annotation 4 GLU D 632
ILE D 631
HIS D 584
VAL D 562
 None
 1.11A 4a97H-6d6vD:
undetectable		 4a97H-6d6vD:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f0k FE-S-CLUSTER-CONTAIN
ING HYDROGENASE

(Rhodothermus
marinus) 		no annotation 4 ILE B  91
TYR B  99
HIS B 538
VAL B 481
 None
 1.05A 4a97H-6f0kB:
undetectable		 4a97H-6f0kB:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g3u -

(-) 		no annotation 4 GLU A 615
ILE A 619
GLU A 616
VAL A 410
 None
 1.08A 4a97H-6g3uA:
undetectable		 4a97H-6g3uA:
undetectable