SIMILAR PATTERNS OF AMINO ACIDS FOR 4A97_E_ZPCE1318

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1air PECTATE LYASE C

(Dickeya
chrysanthemi) 		PF00544
(Pec_lyase_C) 		4 PHE A 103
VAL A  82
ILE A  33
GLU A  60
 None
 0.95A 4a97D-1airA:
undetectable		 4a97D-1airA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bf6 PHOSPHOTRIESTERASE
HOMOLOGY PROTEIN

(Escherichia
coli) 		PF02126
(PTE) 		4 PHE A   3
VAL A  78
ARG A 153
ILE A 122
 None
 0.98A 4a97D-1bf6A:
0.0		 4a97D-1bf6A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1by7 PROTEIN (PLASMINOGEN
ACTIVATOR
INHIBITOR-2)

(Homo sapiens) 		PF00079
(Serpin) 		4 VAL A 173
ILE A 169
ASN A 170
GLU A 315
 None
 1.10A 4a97D-1by7A:
undetectable		 4a97D-1by7A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1byr PROTEIN
(ENDONUCLEASE)

(Salmonella
enterica) 		PF13091
(PLDc_2) 		4 PHE A 110
VAL A  19
ILE A  23
GLU A 122
 None
 0.97A 4a97D-1byrA:
undetectable		 4a97D-1byrA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ciy CRYIA(A)

(Bacillus
thuringiensis) 		PF00555
(Endotoxin_M)
PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N) 		4 PHE A 574
TYR A 522
VAL A 524
ILE A 601
 None
 1.08A 4a97D-1ciyA:
4.0		 4a97D-1ciyA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eth TRIACYLGLYCEROL
ACYL-HYDROLASE

(Sus scrofa) 		PF00151
(Lipase)
PF01477
(PLAT) 		4 PHE A 387
TYR A 341
VAL A 343
ILE A 419
 None
 0.99A 4a97D-1ethA:
0.0		 4a97D-1ethA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f82 BOTULINUM NEUROTOXIN
TYPE B

(Clostridium
botulinum) 		PF01742
(Peptidase_M27) 		4 PHE A 154
VAL A 135
ARG A  27
ILE A 132
 None
 0.99A 4a97D-1f82A:
0.0		 4a97D-1f82A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kfu M-CALPAIN LARGE
SUBUNIT

(Homo sapiens) 		PF00648
(Peptidase_C2)
PF01067
(Calpain_III)
PF13833
(EF-hand_8) 		4 PHE L 475
VAL L 409
ILE L 499
GLU L 460
 None
 0.80A 4a97D-1kfuL:
0.0		 4a97D-1kfuL:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lpb LIPASE

(Homo sapiens) 		PF00151
(Lipase)
PF01477
(PLAT) 		4 PHE B 386
TYR B 340
VAL B 342
ILE B 420
 None
 0.88A 4a97D-1lpbB:
0.0		 4a97D-1lpbB:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nba N-CARBAMOYLSARCOSINE
AMIDOHYDROLASE

(Arthrobacter
sp.) 		PF00857
(Isochorismatase) 		4 VAL A  75
MET A  68
ILE A  71
GLU A 139
 None
 0.60A 4a97D-1nbaA:
undetectable		 4a97D-1nbaA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q9p HIV-1 PROTEASE

(Homo sapiens) 		PF00077
(RVP) 		4 TYR A  59
VAL A  75
ILE A  64
GLU A  35
 None
 1.10A 4a97D-1q9pA:
undetectable		 4a97D-1q9pA:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qgi PROTEIN
(CHITOSANASE)

(Bacillus
circulans) 		PF01374
(Glyco_hydro_46) 		4 MET A  30
ILE A  33
ASN A  34
GLU A  51
 None
 0.97A 4a97D-1qgiA:
undetectable		 4a97D-1qgiA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qjo DIHYDROLIPOAMIDE
ACETYLTRANSFERASE

(Escherichia
coli) 		PF00364
(Biotin_lipoyl) 		4 VAL A  65
MET A  72
ILE A  71
GLU A  38
 None
 1.05A 4a97D-1qjoA:
undetectable		 4a97D-1qjoA:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rrh SEED LIPOXYGENASE-3

(Glycine max) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		4 PHE A  53
VAL A  58
ILE A 117
ASN A 119
 None
 1.07A 4a97D-1rrhA:
undetectable		 4a97D-1rrhA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1twd COPPER HOMEOSTASIS
PROTEIN CUTC

(Shigella
flexneri) 		PF03932
(CutC) 		4 VAL A 118
MET A 106
ILE A 109
GLU A   5
 None
 1.06A 4a97D-1twdA:
undetectable		 4a97D-1twdA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vpk DNA POLYMERASE III,
BETA SUBUNIT

(Thermotoga
maritima) 		PF00712
(DNA_pol3_beta)
PF02767
(DNA_pol3_beta_2)
PF02768
(DNA_pol3_beta_3) 		4 PHE A  68
VAL A  70
MET A  78
ILE A  75
 None
 1.08A 4a97D-1vpkA:
undetectable		 4a97D-1vpkA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wu8 HYPOTHETICAL PROTEIN
PH0463

(Pyrococcus
horikoshii) 		PF01887
(SAM_adeno_trans) 		4 TYR A  85
VAL A  87
ILE A 109
GLU A 140
 None
 1.09A 4a97D-1wu8A:
undetectable		 4a97D-1wu8A:
24.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wxx HYPOTHETICAL PROTEIN
TTHA1280

(Thermus
thermophilus) 		PF10672
(Methyltrans_SAM) 		5 PHE A 335
TYR A 304
VAL A 339
ILE A 312
ASN A 308
 None
 1.30A 4a97D-1wxxA:
undetectable		 4a97D-1wxxA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xew SMC PROTEIN

(Pyrococcus
furiosus) 		PF02463
(SMC_N) 		4 PHE X  12
TYR X  15
VAL X  82
ILE X  84
 None
 0.92A 4a97D-1xewX:
undetectable		 4a97D-1xewX:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xl3 PROTEIN TYPE A

(Yersinia pestis) 		PF09059
(TyeA) 		4 PHE C  60
VAL C  16
MET C   9
ILE C  12
 None
 1.04A 4a97D-1xl3C:
4.4		 4a97D-1xl3C:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xmx HYPOTHETICAL PROTEIN
VC1899

(Vibrio cholerae) 		PF09002
(DUF1887) 		4 PHE A 106
TYR A 109
VAL A  87
ILE A   3
 None
 0.96A 4a97D-1xmxA:
undetectable		 4a97D-1xmxA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yal CHYMOPAPAIN

(Carica papaya) 		PF00112
(Peptidase_C1) 		4 VAL A 161
MET A 191
ILE A 177
ASN A 179
 None
 0.93A 4a97D-1yalA:
undetectable		 4a97D-1yalA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eaa 7S GLOBULIN-3

(Vigna angularis) 		PF00190
(Cupin_1) 		4 PHE A  47
TYR A  60
VAL A  62
ILE A 134
 None
 0.89A 4a97D-2eaaA:
undetectable		 4a97D-2eaaA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f6h MYOSIN-2

(Saccharomyces
cerevisiae) 		PF01843
(DIL) 		4 PHE X 168
TYR X 129
VAL X 125
ILE X 175
 None
 1.07A 4a97D-2f6hX:
2.7		 4a97D-2f6hX:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fk7 METHOXY MYCOLIC ACID
SYNTHASE 4

(Mycobacterium
tuberculosis) 		PF02353
(CMAS) 		4 TYR A  59
VAL A  62
ILE A 145
GLU A  93
 None
 0.96A 4a97D-2fk7A:
undetectable		 4a97D-2fk7A:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fuq HEPARINASE II
PROTEIN

(Pedobacter
heparinus) 		PF07940
(Hepar_II_III)
PF16332
(DUF4962) 		4 TYR A 417
ARG A 384
ILE A 382
GLU A 648
 None
 1.06A 4a97D-2fuqA:
4.6		 4a97D-2fuqA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gwn DIHYDROOROTASE

(Porphyromonas
gingivalis) 		PF01979
(Amidohydro_1) 		4 PHE A 415
VAL A 396
ILE A 401
GLU A 345
 None
 1.10A 4a97D-2gwnA:
undetectable		 4a97D-2gwnA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qc7 ENDOPLASMIC
RETICULUM PROTEIN
ERP29

(Homo sapiens) 		PF07749
(ERp29)
PF07912
(ERp29_N) 		4 PHE A  46
VAL A  91
ILE A  93
ASN A 101
 None
 1.00A 4a97D-2qc7A:
2.7		 4a97D-2qc7A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qn0 NEUROTOXIN

(Clostridium
botulinum) 		PF01742
(Peptidase_M27) 		4 TYR A 202
VAL A 379
ILE A 256
GLU A 360
 None
 1.01A 4a97D-2qn0A:
undetectable		 4a97D-2qn0A:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uut RNA-DIRECTED RNA
POLYMERASE

(Sapporo virus) 		PF00680
(RdRP_1) 		4 PHE A 337
TYR A  90
VAL A  87
ILE A 261
 None
 1.11A 4a97D-2uutA:
undetectable		 4a97D-2uutA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v8p 4-DIPHOSPHOCYTIDYL-2
-C-METHYL-D-ERYTHRIT
OL KINASE

(Aquifex
aeolicus) 		PF00288
(GHMP_kinases_N) 		4 TYR A  63
VAL A  62
ILE A  83
GLU A  70
 None
 1.03A 4a97D-2v8pA:
undetectable		 4a97D-2v8pA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yjg LACTATE RACEMASE
APOPROTEIN

(Thermoanaerobacterium
thermosaccharolyticum) 		PF09861
(DUF2088) 		4 TYR A 381
VAL A 384
ILE A 293
GLU A 397
 None
 0.93A 4a97D-2yjgA:
undetectable		 4a97D-2yjgA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z3k LEUCYL/PHENYLALANYL-
TRNA-PROTEIN
TRANSFERASE

(Escherichia
coli) 		PF03588
(Leu_Phe_trans) 		4 TYR A  87
VAL A  89
MET A 144
ILE A 132
 None
None
PHE  A 302 ( 3.6A)
None
 0.79A 4a97D-2z3kA:
undetectable		 4a97D-2z3kA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zi8 PROBABLE
BIPHENYL-2,3-DIOL
1,2-DIOXYGENASE BPHC

(Mycobacterium
tuberculosis) 		PF00903
(Glyoxalase) 		4 PHE A 136
VAL A 218
MET A 257
ILE A 265
 None
 0.93A 4a97D-2zi8A:
undetectable		 4a97D-2zi8A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zsg AMINOPEPTIDASE P,
PUTATIVE

(Thermotoga
maritima) 		PF00557
(Peptidase_M24)
PF01321
(Creatinase_N) 		4 PHE A  38
ILE A  24
ASN A  23
GLU A  67
 None
 1.07A 4a97D-2zsgA:
undetectable		 4a97D-2zsgA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3al8 SEMAPHORIN-6A

(Mus musculus) 		PF01403
(Sema)
PF01437
(PSI) 		4 PHE A 291
TYR A 292
ILE A 295
ASN A 294
 None
 1.09A 4a97D-3al8A:
undetectable		 4a97D-3al8A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bm3 PSPGI RESTRICTION
ENDONUCLEASE

(Pyrococcus sp.
GI-H) 		PF09019
(EcoRII-C) 		4 PHE A 104
VAL A 159
ILE A 157
GLU A  60
 None
 0.66A 4a97D-3bm3A:
4.4		 4a97D-3bm3A:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dg8 BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE

(Plasmodium
falciparum) 		PF00186
(DHFR_1) 		4 VAL A 140
MET A 104
ILE A 126
ASN A 124
 None
RJ6  A 609 ( 4.0A)
None
None
 0.96A 4a97D-3dg8A:
undetectable		 4a97D-3dg8A:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eei 5-METHYLTHIOADENOSIN
E
NUCLEOSIDASE/S-ADENO
SYLHOMOCYSTEINE
NUCLEOSIDASE

(Neisseria
meningitidis) 		PF01048
(PNP_UDP_1) 		4 VAL A 172
ARG A 166
ILE A 165
GLU A 145
 None
 1.07A 4a97D-3eeiA:
undetectable		 4a97D-3eeiA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ejg NON-STRUCTURAL
PROTEIN 3

(Human
coronavirus
229E) 		PF01661
(Macro) 		4 PHE A   6
TYR A  15
VAL A 150
ILE A 120
 None
 0.96A 4a97D-3ejgA:
undetectable		 4a97D-3ejgA:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eo6 PROTEIN OF UNKNOWN
FUNCTION (DUF1255)

(Acidithiobacillus
ferrooxidans) 		PF06865
(DUF1255) 		4 VAL A  59
MET A  83
ILE A  57
GLU A  97
 None
 0.99A 4a97D-3eo6A:
undetectable		 4a97D-3eo6A:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ewr NON-STRUCTURAL
PROTEIN 3

(Human
coronavirus
229E) 		PF01661
(Macro) 		4 PHE A   7
TYR A  16
VAL A 151
ILE A 121
 None
None
APR  A 169 ( 4.6A)
None
 0.93A 4a97D-3ewrA:
undetectable		 4a97D-3ewrA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fmq METHIONINE
AMINOPEPTIDASE 2

(Encephalitozoon
cuniculi) 		PF00557
(Peptidase_M24) 		4 PHE A 148
VAL A 146
MET A 101
ILE A 129
 None
 1.06A 4a97D-3fmqA:
undetectable		 4a97D-3fmqA:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i83 2-DEHYDROPANTOATE
2-REDUCTASE

(Methylococcus
capsulatus) 		PF02558
(ApbA)
PF08546
(ApbA_C) 		4 TYR A 293
VAL A 292
ILE A 219
GLU A 300
 None
 0.84A 4a97D-3i83A:
2.7		 4a97D-3i83A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ib5 SEX PHEROMONE
PRECURSOR

(Lactobacillus
salivarius) 		PF07537
(CamS) 		4 TYR A 146
VAL A 147
MET A 227
ILE A 172
 None
 0.84A 4a97D-3ib5A:
undetectable		 4a97D-3ib5A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ihp UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 5

(Homo sapiens) 		PF00443
(UCH)
PF00627
(UBA)
PF02148
(zf-UBP) 		4 PHE A 461
TYR A 568
VAL A 570
ILE A 827
 None
 1.05A 4a97D-3ihpA:
undetectable		 4a97D-3ihpA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j82 C-TYPE LECTIN DOMAIN
FAMILY 9 MEMBER A

(Mus musculus) 		PF00059
(Lectin_C) 		4 TYR A 236
VAL A 198
MET A 181
ILE A 175
 None
 0.98A 4a97D-3j82A:
undetectable		 4a97D-3j82A:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jb9 PRE-MRNA-SPLICING
FACTOR CWF4

(Schizosaccharomyces
pombe) 		PF02184
(HAT) 		4 TYR R 194
VAL R 198
ASN R 206
GLU R 214
 None
 1.05A 4a97D-3jb9R:
4.8		 4a97D-3jb9R:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kq0 ALPHA-1-ACID
GLYCOPROTEIN 1

(Homo sapiens) 		PF00061
(Lipocalin) 		4 PHE A  32
TYR A  37
VAL A  41
ILE A  44
 None
 1.06A 4a97D-3kq0A:
undetectable		 4a97D-3kq0A:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ltf PROTEIN SPITZ

(Drosophila
melanogaster) 		no annotation 4 PHE D  23
VAL D  25
ILE D  27
GLU D  36
 None
 0.84A 4a97D-3ltfD:
undetectable		 4a97D-3ltfD:
10.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ltg PROTEIN SPITZ

(Drosophila
melanogaster) 		PF00008
(EGF) 		4 PHE D  23
VAL D  25
ILE D  27
GLU D  36
 None
 0.81A 4a97D-3ltgD:
undetectable		 4a97D-3ltgD:
10.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ml6 CHIMERIC COMPLEX
BETWEEN PROTEIN
DISHEVLLED2 HOMOLOG
DVL-2 AND CLATHRIN
ADAPTOR AP-2 COMPLEX
SUBUNIT MU

(Mus musculus;
Rattus
norvegicus) 		PF00610
(DEP)
PF00928
(Adap_comp_sub) 		4 PHE A 469
TYR A 463
VAL A 466
MET A 430
 None
 0.93A 4a97D-3ml6A:
2.2		 4a97D-3ml6A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pco PHENYLALANYL-TRNA
SYNTHETASE, BETA
CHAIN

(Escherichia
coli) 		PF01588
(tRNA_bind)
PF03147
(FDX-ACB)
PF03483
(B3_4)
PF03484
(B5) 		4 VAL B 250
ILE B 246
ASN B 254
GLU B 334
 None
 1.06A 4a97D-3pcoB:
undetectable		 4a97D-3pcoB:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3um6 BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE

(Plasmodium
falciparum) 		PF00186
(DHFR_1)
PF00303
(Thymidylat_synt) 		4 VAL A 140
MET A 104
ILE A 126
ASN A 124
 None
1CY  A 609 ( 4.5A)
None
None
 0.81A 4a97D-3um6A:
undetectable		 4a97D-3um6A:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v9e LACCASE

(Botrytis aclada) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 PHE A 393
TYR A 397
VAL A 399
GLU A 390
 None
 0.96A 4a97D-3v9eA:
undetectable		 4a97D-3v9eA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vtz GLUCOSE
1-DEHYDROGENASE

(Thermoplasma
volcanium) 		PF13561
(adh_short_C2) 		4 TYR A 109
VAL A 105
ILE A 101
ASN A 106
 None
 0.91A 4a97D-3vtzA:
undetectable		 4a97D-3vtzA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wiq KOJIBIOSE
PHOSPHORYLASE

(Caldicellulosiruptor
saccharolyticus) 		PF03632
(Glyco_hydro_65m)
PF03633
(Glyco_hydro_65C)
PF03636
(Glyco_hydro_65N) 		4 PHE A 655
VAL A 307
ILE A 311
ASN A 310
 None
 0.93A 4a97D-3wiqA:
3.0		 4a97D-3wiqA:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wr7 SPERMIDINE
N1-ACETYLTRANSFERASE

(Escherichia
coli) 		PF13302
(Acetyltransf_3) 		4 TYR A  30
VAL A 122
ILE A 130
ASN A 126
 COA  A 202 (-3.4A)
COA  A 202 ( 4.8A)
None
COA  A 202 ( 4.7A)
 1.04A 4a97D-3wr7A:
undetectable		 4a97D-3wr7A:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zq4 RIBONUCLEASE J 1

(Bacillus
subtilis) 		PF00753
(Lactamase_B)
PF07521
(RMMBL) 		4 PHE A 130
VAL A 128
ILE A 122
GLU A  32
 None
 0.89A 4a97D-3zq4A:
undetectable		 4a97D-3zq4A:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ae0 DIPHTHERIA TOXIN

(Corynebacterium
diphtheriae) 		PF01324
(Diphtheria_R)
PF02763
(Diphtheria_C)
PF02764
(Diphtheria_T) 		4 PHE A  17
VAL A 135
ILE A 150
ASN A 151
 None
 0.84A 4a97D-4ae0A:
2.9		 4a97D-4ae0A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4avo BETA-1,4-EXOCELLULAS
E

(Thermobifida
fusca) 		PF01341
(Glyco_hydro_6) 		4 TYR A 397
VAL A 398
ARG A 387
ILE A 386
 None
 0.97A 4a97D-4avoA:
undetectable		 4a97D-4avoA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bwf UBIQUITIN-CONJUGATIN
G ENZYME E2-21 KDA

(Saccharomyces
cerevisiae) 		PF00179
(UQ_con) 		4 ARG A 177
ILE A 102
ASN A 101
GLU A  62
 None
 0.86A 4a97D-4bwfA:
undetectable		 4a97D-4bwfA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c8q DNA TOPOISOMERASE
2-ASSOCIATED PROTEIN
PAT1

(Saccharomyces
cerevisiae) 		PF09770
(PAT1) 		4 PHE H 681
VAL H 727
ILE H 724
GLU H 701
 None
None
None
CO  H1080 (-3.8A)
 1.05A 4a97D-4c8qH:
undetectable		 4a97D-4c8qH:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eg9 UNCHARACTERIZED
PROTEIN
SAOUHSC_02783

(Staphylococcus
aureus) 		PF04507
(DUF576) 		4 VAL A  95
ILE A  75
ASN A  77
GLU A 126
 None
 0.79A 4a97D-4eg9A:
undetectable		 4a97D-4eg9A:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hpf POTASSIUM CHANNEL
SUBFAMILY U MEMBER 1

(Homo sapiens) 		PF03493
(BK_channel_a) 		4 TYR A 917
ILE A 472
ASN A 471
GLU A 558
 None
 1.03A 4a97D-4hpfA:
undetectable		 4a97D-4hpfA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4my5 PUTATIVE AMINO ACID
AMINOTRANSFERASE

(Streptococcus
mutans) 		PF00155
(Aminotran_1_2) 		4 TYR A 208
ILE A 171
ASN A 173
GLU A  39
 None
 1.07A 4a97D-4my5A:
undetectable		 4a97D-4my5A:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p27 VENOM ALLERGEN-LIKE
(VAL) 4 PROTEIN

(Schistosoma
mansoni) 		PF00188
(CAP) 		4 PHE A  14
VAL A  18
ILE A  27
GLU A  85
 None
 0.92A 4a97D-4p27A:
undetectable		 4a97D-4p27A:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p68 DIHYDROFOLATE
REDUCTASE

(Escherichia
coli) 		PF00186
(DHFR_1) 		4 VAL A  72
MET A  42
ILE A  61
ASN A  59
 None
None
None
XCN  A  54 ( 3.0A)
 0.84A 4a97D-4p68A:
undetectable		 4a97D-4p68A:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q3o MGS-MT1

(unidentified) 		PF07859
(Abhydrolase_3) 		4 TYR A 157
VAL A 155
MET A 190
ILE A 122
 None
 1.06A 4a97D-4q3oA:
undetectable		 4a97D-4q3oA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q8k ALGINASE

(Pseudoalteromonas
sp. SM0524) 		PF08787
(Alginate_lyase2) 		4 PHE A 239
TYR A 395
VAL A 393
ILE A 175
 None
 1.03A 4a97D-4q8kA:
undetectable		 4a97D-4q8kA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q8l ALGINASE

(Pseudoalteromonas
sp. SM0524) 		PF08787
(Alginate_lyase2) 		4 PHE A  72
TYR A 228
VAL A 226
ILE A   8
 None
 1.02A 4a97D-4q8lA:
undetectable		 4a97D-4q8lA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qni UNCHARACTERIZED
PROTEIN

(Bacteroides
thetaiotaomicron) 		PF14274
(DUF4361)
PF16343
(DUF4973) 		4 TYR A 328
VAL A 330
ILE A 200
ASN A 202
 None
None
EDO  A 403 ( 4.1A)
EDO  A 403 ( 4.9A)
 0.98A 4a97D-4qniA:
undetectable		 4a97D-4qniA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rep GAMMA-CAROTENE
DESATURASE

(Nonlabens
dokdonensis) 		PF01593
(Amino_oxidase) 		4 VAL A 257
MET A 286
ILE A 250
GLU A 486
 None
 0.95A 4a97D-4repA:
undetectable		 4a97D-4repA:
20.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4twf CYS-LOOP
LIGAND-GATED ION
CHANNEL

(Dickeya
chrysanthemi) 		PF02931
(Neur_chan_LBD) 		6 PHE A  19
TYR A  38
VAL A  40
ARG A  91
MET A  93
ILE A 101
 None
 0.45A 4a97D-4twfA:
33.6		 4a97D-4twfA:
99.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4twf CYS-LOOP
LIGAND-GATED ION
CHANNEL

(Dickeya
chrysanthemi) 		PF02931
(Neur_chan_LBD) 		5 PHE A  19
VAL A  40
ARG A  91
MET A  93
ASN A 103
 None
 0.85A 4a97D-4twfA:
33.6		 4a97D-4twfA:
99.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4twf CYS-LOOP
LIGAND-GATED ION
CHANNEL

(Dickeya
chrysanthemi) 		PF02931
(Neur_chan_LBD) 		4 TYR A  38
ARG A  91
MET A  93
GLU A 150
 None
 0.91A 4a97D-4twfA:
33.6		 4a97D-4twfA:
99.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4txk PROTEIN-METHIONINE
SULFOXIDE OXIDASE
MICAL1

(Mus musculus) 		PF00307
(CH)
PF01494
(FAD_binding_3) 		4 PHE A 351
VAL A 361
MET A 296
ILE A 240
 None
 0.98A 4a97D-4txkA:
undetectable		 4a97D-4txkA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4unw H3 HAEMAGGLUTININ
HA1 CHAIN

(Influenza A
virus) 		PF00509
(Hemagglutinin) 		4 TYR A  56
VAL A  58
MET A 268
ILE A  88
 None
 0.98A 4a97D-4unwA:
undetectable		 4a97D-4unwA:
22.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4yeu CYS-LOOP
LIGAND-GATED ION
CHANNEL,PROTON-GATED
ION CHANNEL

(Dickeya
chrysanthemi;
Gloeobacter
violaceus) 		PF02931
(Neur_chan_LBD) 		6 PHE A  19
TYR A  38
VAL A  40
ARG A  91
ILE A 101
ASN A 103
 None
 0.55A 4a97D-4yeuA:
29.5		 4a97D-4yeuA:
71.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4yeu CYS-LOOP
LIGAND-GATED ION
CHANNEL,PROTON-GATED
ION CHANNEL

(Dickeya
chrysanthemi;
Gloeobacter
violaceus) 		PF02931
(Neur_chan_LBD) 		5 PHE A  19
VAL A  40
ARG A  91
MET A  93
ILE A 101
 None
 0.65A 4a97D-4yeuA:
29.5		 4a97D-4yeuA:
71.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z81 EGF FAMILY
DOMAIN-CONTAINING
PROTEIN

(Toxoplasma
gondii) 		PF02430
(AMA-1)
PF07974
(EGF_2) 		4 PHE A 367
TYR A 368
VAL A 370
ILE A 154
 None
 1.10A 4a97D-4z81A:
undetectable		 4a97D-4z81A:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aee ALPHA-GLUCOSIDASE
YIHQ

(Escherichia
coli) 		PF01055
(Glyco_hydro_31) 		4 PHE A 530
VAL A 564
ARG A 560
ILE A 678
 None
 1.09A 4a97D-5aeeA:
undetectable		 4a97D-5aeeA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5czz CRISPR-ASSOCIATED
ENDONUCLEASE CAS9

(Staphylococcus
aureus) 		PF13395
(HNH_4)
PF16592
(Cas9_REC) 		4 ARG A 980
ILE A 982
ASN A 995
GLU A1006
 None
 1.02A 4a97D-5czzA:
undetectable		 4a97D-5czzA:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dxv RETHREADED DHFR

(synthetic
construct) 		PF00186
(DHFR_1) 		4 VAL A  89
MET A  59
ILE A  78
ASN A  76
 None
 0.78A 4a97D-5dxvA:
undetectable		 4a97D-5dxvA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5flz SPINDLE POLE BODY
COMPONENT SPC98

(Saccharomyces
cerevisiae) 		PF04130
(Spc97_Spc98) 		4 TYR B 187
VAL B 188
ILE B 224
GLU B 182
 None
 1.07A 4a97D-5flzB:
2.8		 4a97D-5flzB:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ii5 MALTOSE-BINDING
PERIPLASMIC
PROTEIN,VITELLINE
ENVELOPE SPERM LYSIN
RECEPTOR

(Escherichia
coli;
Haliotis
rufescens) 		PF11386
(VERL)
PF13416
(SBP_bac_8) 		4 PHE A4106
VAL A4123
MET A4077
ILE A4070
 None
 0.80A 4a97D-5ii5A:
undetectable		 4a97D-5ii5A:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jb3 30S RIBOSOMAL
PROTEIN S3

(Pyrococcus
abyssi) 		PF00189
(Ribosomal_S3_C)
PF07650
(KH_2) 		4 TYR Z 166
VAL Z 180
ILE Z 130
GLU Z  22
 G  21010 ( 4.4A)
None
None
None
 0.95A 4a97D-5jb3Z:
undetectable		 4a97D-5jb3Z:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l0l UNCHARACTERIZED
PROTEIN

(Legionella
pneumophila) 		no annotation 4 TYR A 130
VAL A 132
MET A 224
ILE A 144
 None
 0.82A 4a97D-5l0lA:
undetectable		 4a97D-5l0lA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lw7 ABC TRANSPORTER
ATP-BINDING PROTEIN

(Pyrococcus
abyssi) 		PF00005
(ABC_tran)
PF00037
(Fer4)
PF04068
(RLI) 		4 PHE B 322
TYR B 288
VAL B 286
ILE B 284
 None
 1.09A 4a97D-5lw7B:
undetectable		 4a97D-5lw7B:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mc5 XAA-PRO DIPEPTIDASE

(Homo sapiens) 		no annotation 4 PHE A  96
TYR A  83
VAL A  85
ILE A  45
 None
 0.64A 4a97D-5mc5A:
undetectable		 4a97D-5mc5A:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mpd 26S PROTEASOME
REGULATORY SUBUNIT
RPN6

(Saccharomyces
cerevisiae) 		PF01399
(PCI) 		4 VAL Q 302
MET Q 271
ILE Q 270
GLU Q 322
 None
 0.95A 4a97D-5mpdQ:
2.2		 4a97D-5mpdQ:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n0l GTP-SENSING
TRANSCRIPTIONAL
PLEIOTROPIC
REPRESSOR CODY

(Clostridioides
difficile) 		no annotation 4 PHE A  74
TYR A  78
VAL A  82
ILE A  85
 ILE  A 201 ( 4.7A)
None
None
None
 1.02A 4a97D-5n0lA:
undetectable		 4a97D-5n0lA:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n7q PUTATIVE CATHEPSIN D

(Ixodes ricinus) 		no annotation 4 VAL A 155
ARG A 332
ILE A 325
GLU A 152
 None
 0.90A 4a97D-5n7qA:
undetectable		 4a97D-5n7qA:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tcb PELA

(Pseudomonas
aeruginosa) 		PF03537
(Glyco_hydro_114) 		4 PHE A 202
VAL A 217
ILE A 220
GLU A 203
 None
 1.03A 4a97D-5tcbA:
undetectable		 4a97D-5tcbA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tph DE NOVO NTF2
HOMODIMER

(synthetic
construct) 		PF12680
(SnoaL_2) 		4 PHE A  42
VAL A  37
MET A  89
GLU A  47
 None
 1.01A 4a97D-5tphA:
undetectable		 4a97D-5tphA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uwb TOLUENE TOLERANCE
PROTEIN

(Pseudomonas
putida) 		no annotation 4 TYR B 144
VAL B 164
ILE B 167
ASN B 165
 PEF  B 302 (-4.0A)
PEF  B 302 ( 4.6A)
None
PEF  B 302 ( 4.1A)
 1.00A 4a97D-5uwbB:
undetectable		 4a97D-5uwbB:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yfb DIPEPTIDYL PEPTIDASE
3

(Armillaria
tabescens) 		no annotation 4 TYR A 313
VAL A 314
ILE A 164
GLU A 324
 None
 1.00A 4a97D-5yfbA:
undetectable		 4a97D-5yfbA:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d46 BETA SLIDING CLAMP

(Rickettsia
typhi) 		no annotation 4 PHE A 353
TYR A 352
VAL A 362
ILE A 376
 None
 0.98A 4a97D-6d46A:
undetectable		 4a97D-6d46A:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f36 MITOCHONDRIAL ATP
SYNTHASE SUBUNIT
ASA6

(Polytomella sp.
Pringsheim
198.80) 		no annotation 4 PHE N 129
TYR N 126
VAL N 125
ILE N 120
 None
 1.09A 4a97D-6f36N:
undetectable		 4a97D-6f36N:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fhs ARP5

(Chaetomium
thermophilum) 		no annotation 4 VAL J  68
MET J 158
ILE J  61
ASN J  63
 None
 0.73A 4a97D-6fhsJ:
undetectable		 4a97D-6fhsJ:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1akm ORNITHINE
TRANSCARBAMYLASE

(Escherichia
coli) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		4 GLU A  18
HIS A   5
VAL A 124
PHE A  14
 None
 1.22A 4a97E-1akmA:
0.0		 4a97E-1akmA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e8t HEMAGGLUTININ-NEURAM
INIDASE

(Avian
avulavirus 1) 		PF00423
(HN) 		4 PHE A 220
TYR A 185
HIS A 184
PHE A 221
 None
None
GOL  A1002 (-4.1A)
None
 1.01A 4a97E-1e8tA:
0.0		 4a97E-1e8tA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eu8 TREHALOSE/MALTOSE
BINDING PROTEIN

(Thermococcus
litoralis) 		PF01547
(SBP_bac_1) 		4 PHE A 315
TYR A  20
VAL A  11
PHE A 325
 None
 1.21A 4a97E-1eu8A:
0.0		 4a97E-1eu8A:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f1x HOMOPROTOCATECHUATE
2,3-DIOXYGENASE

(Brevibacterium
fuscum) 		PF00903
(Glyoxalase) 		4 GLU A 127
PHE A  79
TYR A  20
PHE A 129
 None
 1.10A 4a97E-1f1xA:
0.0		 4a97E-1f1xA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gbg (1,3-1,4)-BETA-D-GLU
CAN 4
GLUCANOHYDROLASE

(Bacillus
licheniformis) 		PF00722
(Glyco_hydro_16) 		4 GLU A  46
PHE A  10
TYR A 144
HIS A 145
 None
 1.11A 4a97E-1gbgA:
undetectable		 4a97E-1gbgA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ofm CHONDROITINASE B

(Pedobacter
heparinus) 		PF14592
(Chondroitinas_B) 		4 GLU A 446
TYR A 197
HIS A 198
VAL A 232
 None
 1.07A 4a97E-1ofmA:
undetectable		 4a97E-1ofmA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ohf NUDAURELIA CAPENSIS
OMEGA VIRUS CAPSID
PROTEIN

(Nudaurelia
capensis omega
virus) 		PF03566
(Peptidase_A21) 		4 PHE A 408
TYR A 341
VAL A 338
PHE A 325
 None
 1.18A 4a97E-1ohfA:
1.2		 4a97E-1ohfA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1paq TRANSLATION
INITIATION FACTOR
EIF-2B EPSILON
SUBUNIT

(Saccharomyces
cerevisiae) 		PF02020
(W2) 		4 TYR A 597
HIS A 598
VAL A 614
PHE A 648
 None
 1.04A 4a97E-1paqA:
undetectable		 4a97E-1paqA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qfc PROTEIN (PURPLE ACID
PHOSPHATASE)

(Rattus
norvegicus) 		PF00149
(Metallophos) 		4 GLU A  69
PHE A  23
TYR A 104
VAL A  98
 None
 0.96A 4a97E-1qfcA:
0.0		 4a97E-1qfcA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qnh PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE

(Plasmodium
falciparum) 		PF00160
(Pro_isomerase) 		4 TYR A  55
HIS A  54
VAL A 164
PHE A 119
 None
 1.20A 4a97E-1qnhA:
undetectable		 4a97E-1qnhA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v47 ATP SULFURYLASE

(Thermus
thermophilus) 		PF01747
(ATP-sulfurylase)
PF14306
(PUA_2) 		4 PHE A  26
HIS A  77
VAL A 130
PHE A  32
 None
 1.22A 4a97E-1v47A:
undetectable		 4a97E-1v47A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v9d DIAPHANOUS PROTEIN
HOMOLOG 1

(Mus musculus) 		PF02181
(FH2) 		4 PHE A 850
TYR A 854
VAL A 913
PHE A 906
 None
 1.15A 4a97E-1v9dA:
4.3		 4a97E-1v9dA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wst MULTIPLE SUBSTRATE
AMINOTRANSFERASE

(Thermococcus
profundus) 		PF00155
(Aminotran_1_2) 		4 GLU A 227
TYR A 100
HIS A 240
VAL A 107
 None
 1.13A 4a97E-1wstA:
undetectable		 4a97E-1wstA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wst MULTIPLE SUBSTRATE
AMINOTRANSFERASE

(Thermococcus
profundus) 		PF00155
(Aminotran_1_2) 		4 GLU A 227
TYR A 100
HIS A 240
VAL A 247
 None
 1.07A 4a97E-1wstA:
undetectable		 4a97E-1wstA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y9q TRANSCRIPTIONAL
REGULATOR, HTH_3
FAMILY

(Vibrio cholerae) 		PF01381
(HTH_3) 		4 GLU A 128
TYR A 164
HIS A 115
VAL A 167
 ZN  A 202 ( 2.5A)
MED  A 201 ( 4.6A)
None
None
 1.13A 4a97E-1y9qA:
undetectable		 4a97E-1y9qA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zvd SMAD UBIQUITINATION
REGULATORY FACTOR 2

(Homo sapiens) 		PF00632
(HECT) 		4 GLU A 404
TYR A 482
HIS A 479
PHE A 403
 None
 1.20A 4a97E-1zvdA:
undetectable		 4a97E-1zvdA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c47 CASEIN KINASE 1
GAMMA 2 ISOFORM

(Homo sapiens) 		PF00069
(Pkinase) 		4 GLU A 169
PHE A 130
TYR A 218
HIS A 240
 None
 1.14A 4a97E-2c47A:
2.3		 4a97E-2c47A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2esf CARBONIC ANHYDRASE 2

(Escherichia
coli) 		PF00484
(Pro_CA) 		4 GLU A 148
TYR A  99
HIS A 184
VAL A  47
 None
 1.07A 4a97E-2esfA:
undetectable		 4a97E-2esfA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g6y GREEN FLUORESCENT
PROTEIN 2

(Pontellina
plumata) 		PF01353
(GFP) 		4 PHE A  47
HIS A  98
VAL A 170
PHE A 121
 None
 1.04A 4a97E-2g6yA:
undetectable		 4a97E-2g6yA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gnp TRANSCRIPTIONAL
REGULATOR

(Streptococcus
pneumoniae) 		PF04198
(Sugar-bind) 		4 GLU A 160
PHE A 115
HIS A 129
VAL A 133
 None
 1.19A 4a97E-2gnpA:
undetectable		 4a97E-2gnpA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hiv THERMOSTABLE DNA
LIGASE

(Sulfolobus
solfataricus) 		PF01068
(DNA_ligase_A_M)
PF04675
(DNA_ligase_A_N)
PF04679
(DNA_ligase_A_C) 		4 GLU A 406
TYR A 259
HIS A 387
VAL A 413
 None
 1.04A 4a97E-2hivA:
undetectable		 4a97E-2hivA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hqj PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE

(Leishmania
major) 		PF00160
(Pro_isomerase) 		4 TYR A  55
HIS A  54
VAL A 167
PHE A 122
 None
PO4  A 180 (-3.6A)
None
None
 1.20A 4a97E-2hqjA:
undetectable		 4a97E-2hqjA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jhq URACIL
DNA-GLYCOSYLASE

(Vibrio cholerae) 		PF03167
(UDG) 		4 GLU A  14
TYR A  19
VAL A  27
PHE A  20
 None
 1.16A 4a97E-2jhqA:
undetectable		 4a97E-2jhqA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qza SECRETED EFFECTOR
PROTEIN

(Salmonella
enterica) 		PF13599
(Pentapeptide_4)
PF13979
(SopA_C)
PF13981
(SopA) 		4 GLU A 396
HIS A 467
VAL A 474
PHE A 425
 None
 1.12A 4a97E-2qzaA:
2.0		 4a97E-2qzaA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vmf BETA-MANNOSIDASE

(Bacteroides
thetaiotaomicron) 		PF00703
(Glyco_hydro_2) 		4 GLU A  90
PHE A 156
TYR A 153
HIS A 151
 EDO  A1875 (-3.3A)
None
None
None
 1.08A 4a97E-2vmfA:
3.4		 4a97E-2vmfA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wmo DEDICATOR OF
CYTOKINESIS PROTEIN
9

(Homo sapiens) 		PF06920
(DHR-2) 		4 TYR A 155
HIS A 229
VAL A 158
PHE A 287
 None
 0.77A 4a97E-2wmoA:
5.0		 4a97E-2wmoA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xt6 2-OXOGLUTARATE
DECARBOXYLASE

(Mycolicibacterium
smegmatis) 		PF00198
(2-oxoacid_dh)
PF00676
(E1_dh)
PF02779
(Transket_pyr)
PF16870
(OxoGdeHyase_C) 		4 GLU A 341
PHE A 339
TYR A 163
PHE A 224
 None
 1.11A 4a97E-2xt6A:
undetectable		 4a97E-2xt6A:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z23 PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN

(Yersinia pestis) 		PF00496
(SBP_bac_5) 		4 GLU A 422
TYR A 420
HIS A 161
VAL A  48
 None
 1.04A 4a97E-2z23A:
undetectable		 4a97E-2z23A:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zii VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 74

(Saccharomyces
cerevisiae) 		PF05719
(GPP34) 		4 PHE A 247
TYR A 294
VAL A 334
PHE A 296
 None
 1.14A 4a97E-2ziiA:
undetectable		 4a97E-2ziiA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a5k TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 1

(Homo sapiens) 		PF00102
(Y_phosphatase) 		4 TYR A 176
HIS A 175
VAL A 213
PHE A 191
 None
 1.15A 4a97E-3a5kA:
undetectable		 4a97E-3a5kA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3adf MONOMERIC AZAMI
GREEN

(Galaxea
fascicularis) 		PF01353
(GFP) 		4 GLU A 144
TYR A 177
HIS A  88
VAL A 183
 None
 0.99A 4a97E-3adfA:
undetectable		 4a97E-3adfA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bdl STAPHYLOCOCCAL
NUCLEASE
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF00565
(SNase)
PF00567
(TUDOR) 		4 GLU A 726
HIS A 670
VAL A 673
PHE A 737
 None
 1.05A 4a97E-3bdlA:
undetectable		 4a97E-3bdlA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d3m EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4
GAMMA 2

(Homo sapiens) 		PF02020
(W2) 		4 GLU A 864
PHE A 866
HIS A 821
VAL A 769
 None
 1.08A 4a97E-3d3mA:
2.0		 4a97E-3d3mA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d6e BETA-GLUCANASE

(Bacillus
licheniformis) 		PF00722
(Glyco_hydro_16) 		4 GLU A  33
PHE A  10
TYR A 131
HIS A 132
 None
 1.04A 4a97E-3d6eA:
undetectable		 4a97E-3d6eA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ddm PUTATIVE MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME

(Bordetella
bronchiseptica) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 GLU A  56
TYR A 309
HIS A 308
VAL A 149
 None
 1.19A 4a97E-3ddmA:
undetectable		 4a97E-3ddmA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dec BETA-GALACTOSIDASE

(Bacteroides
thetaiotaomicron) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF02929
(Bgal_small_N)
PF16353
(DUF4981) 		4 GLU A 335
TYR A 238
HIS A 237
VAL A 297
 None
 0.98A 4a97E-3decA:
1.6		 4a97E-3decA:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eck PROTEIN
(HOMOPROTOCATECHUATE
2,3-DIOXYGENASE)

(Brevibacterium
fuscum) 		PF00903
(Glyoxalase) 		4 GLU A 127
PHE A  79
TYR A  20
PHE A 129
 None
 1.09A 4a97E-3eckA:
undetectable		 4a97E-3eckA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lqz HLA CLASS II
HISTOCOMPATIBILITY
ANTIGEN, DP ALPHA 1
CHAIN

(Homo sapiens) 		PF00993
(MHC_II_alpha)
PF07654
(C1-set) 		4 GLU A  21
HIS A 108
VAL A 165
PHE A 137
 None
 1.22A 4a97E-3lqzA:
3.6		 4a97E-3lqzA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n3u ADENOSINE
MONOPHOSPHATE-PROTEI
N TRANSFERASE IBPA

(Histophilus
somni) 		PF02661
(Fic) 		4 GLU A3751
TYR A3710
VAL A3704
PHE A3746
 None
 1.06A 4a97E-3n3uA:
undetectable		 4a97E-3n3uA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o5s BETA-GLUCANASE

(Bacillus
subtilis) 		PF00722
(Glyco_hydro_16) 		4 GLU A  74
PHE A  38
TYR A 172
HIS A 173
 None
 1.02A 4a97E-3o5sA:
undetectable		 4a97E-3o5sA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3piv INTERFERON

(Danio rerio) 		PF00143
(Interferon) 		4 GLU A  83
PHE A  85
HIS A  71
VAL A  75
 None
 1.12A 4a97E-3pivA:
2.2		 4a97E-3pivA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pmi PWWP
DOMAIN-CONTAINING
PROTEIN MUM1

(Homo sapiens) 		no annotation 4 PHE A 466
TYR A 496
VAL A 521
PHE A 509
 None
 1.21A 4a97E-3pmiA:
undetectable		 4a97E-3pmiA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pvt PHENYLACETIC ACID
DEGRADATION PROTEIN
PAAA

(Escherichia
coli) 		PF05138
(PaaA_PaaC) 		4 GLU A 263
PHE A 264
TYR A 110
VAL A  44
 None
3HC  A 310 (-4.8A)
None
None
 1.15A 4a97E-3pvtA:
undetectable		 4a97E-3pvtA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q6t 43.2 KDA SALIVARY
PROTEIN

(Lutzomyia
longipalpis) 		PF03022
(MRJP) 		4 GLU A  57
TYR A 135
VAL A 138
PHE A  77
 None
 0.98A 4a97E-3q6tA:
undetectable		 4a97E-3q6tA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rnl SULFOTRANSFERASE

(Alicyclobacillus
acidocaldarius) 		PF13469
(Sulfotransfer_3) 		4 GLU A  85
TYR A  90
VAL A 174
PHE A   9
 None
 1.01A 4a97E-3rnlA:
undetectable		 4a97E-3rnlA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tgh GLIDEOSOME-ASSOCIATE
D PROTEIN 50

(Plasmodium
falciparum) 		PF00149
(Metallophos) 		4 PHE A  29
TYR A 153
HIS A 152
VAL A 102
 None
 1.05A 4a97E-3tghA:
undetectable		 4a97E-3tghA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3to3 PETROBACTIN
BIOSYNTHESIS PROTEIN
ASBB

(Bacillus
anthracis) 		PF04183
(IucA_IucC)
PF06276
(FhuF) 		4 GLU A 346
HIS A 436
VAL A 422
PHE A 457
 None
 1.04A 4a97E-3to3A:
undetectable		 4a97E-3to3A:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u0k RCAMP

(Entacmaea
quadricolor) 		PF01353
(GFP)
PF13499
(EF-hand_7) 		4 PHE A 206
HIS A 269
VAL A 255
PHE A 175
 NFA  A 213 ( 4.7A)
None
None
None
 1.01A 4a97E-3u0kA:
undetectable		 4a97E-3u0kA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u0n MRUBY

(Entacmaea
quadricolor) 		PF01353
(GFP) 		4 PHE A  55
HIS A 118
VAL A 104
PHE A  24
 None
 1.14A 4a97E-3u0nA:
undetectable		 4a97E-3u0nA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ac3 BIFUNCTIONAL PROTEIN
GLMU

(Streptococcus
pneumoniae) 		PF00132
(Hexapep)
PF00483
(NTP_transferase)
PF14602
(Hexapep_2) 		4 GLU A 210
HIS A  95
VAL A  98
PHE A 205
 None
 1.20A 4a97E-4ac3A:
undetectable		 4a97E-4ac3A:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4avx HEPATOCYTE GROWTH
FACTOR-REGULATED
TYROSINE KINASE
SUBSTRATE

(Homo sapiens) 		PF00790
(VHS)
PF01363
(FYVE) 		4 GLU A   9
TYR A  44
VAL A  79
PHE A   8
 None
EDO  A1234 (-4.1A)
None
None
 1.21A 4a97E-4avxA:
2.4		 4a97E-4avxA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4btm TAU-TUBULIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		4 GLU A  71
PHE A 126
TYR A  73
VAL A  84
 None
 1.21A 4a97E-4btmA:
2.2		 4a97E-4btmA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dni FUSION PROTEIN OF
RNA-EDITING COMPLEX
PROTEINS MP42 AND
MP18

(Trypanosoma
brucei) 		PF00436
(SSB) 		4 GLU A 244
TYR A 131
HIS A 132
PHE A 251
 None
 1.16A 4a97E-4dniA:
undetectable		 4a97E-4dniA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e1q PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE

(Triticum
aestivum) 		PF00160
(Pro_isomerase) 		4 TYR A  55
HIS A  54
VAL A 164
PHE A 119
 None
 1.21A 4a97E-4e1qA:
undetectable		 4a97E-4e1qA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4exw SINGLE-STRANDED
DNA-BINDING PROTEIN
DDRB

(Deinococcus
geothermalis) 		PF12747
(DdrB) 		4 GLU A  53
TYR A 103
VAL A  41
PHE A 131
 None
 1.20A 4a97E-4exwA:
undetectable		 4a97E-4exwA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fiu HEMAGGLUTININ

(Influenza A
virus) 		PF00509
(Hemagglutinin) 		4 GLU A  63
HIS A 108
VAL A 113
PHE A  62
 None
 1.16A 4a97E-4fiuA:
undetectable		 4a97E-4fiuA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hy7 PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE

(Triticum
aestivum) 		PF00160
(Pro_isomerase) 		4 TYR A  55
HIS A  54
VAL A 164
PHE A 119
 None
 1.20A 4a97E-4hy7A:
undetectable		 4a97E-4hy7A:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i1f E3 UBIQUITIN-PROTEIN
LIGASE PARKIN

(Homo sapiens) 		PF01485
(IBR) 		4 PHE A 208
HIS A 461
VAL A 465
PHE A 210
 None
ZN  A 508 (-3.2A)
None
None
 1.08A 4a97E-4i1fA:
undetectable		 4a97E-4i1fA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i2y RGECO1

(Discosoma sp.;
Gallus gallus;
Rattus
norvegicus) 		PF01353
(GFP)
PF13499
(EF-hand_7) 		4 PHE A 213
HIS A 263
VAL A  92
PHE A 286
 None
 1.04A 4a97E-4i2yA:
undetectable		 4a97E-4i2yA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ifr 2-AMINO-3-CARBOXYMUC
ONATE 6-SEMIALDEHYDE
DECARBOXYLASE

(Pseudomonas
fluorescens) 		PF04909
(Amidohydro_2) 		4 GLU A  66
TYR A 295
HIS A  11
VAL A 117
 None
None
ZN  A 401 (-3.4A)
None
 1.16A 4a97E-4ifrA:
undetectable		 4a97E-4ifrA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k7d E3 UBIQUITIN-PROTEIN
LIGASE PARKIN

(Rattus
norvegicus) 		PF01485
(IBR) 		4 PHE A 208
HIS A 461
VAL A 465
PHE A 210
 None
ZN  A 508 (-3.3A)
None
None
 1.09A 4a97E-4k7dA:
undetectable		 4a97E-4k7dA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kvs ALDEHYDE
DECARBONYLASE

(Prochlorococcus
marinus) 		PF11266
(Ald_deCOase) 		4 GLU A  45
TYR A 135
HIS A 136
VAL A 141
 FE  A 302 ( 2.4A)
6NA  A 301 ( 4.9A)
None
None
 0.84A 4a97E-4kvsA:
2.5		 4a97E-4kvsA:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4py3 BARTONELLA EFFECTOR
PROTEIN (BEP)
SUBSTRATE OF VIRB
T4SS

(Bartonella sp.
1-1C) 		PF02661
(Fic) 		4 GLU A  75
PHE A  74
HIS A  17
PHE A  87
 None
 1.12A 4a97E-4py3A:
undetectable		 4a97E-4py3A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r4z PNGF-II

(Elizabethkingia
meningoseptica) 		PF09112
(N-glycanase_N)
PF09113
(N-glycanase_C) 		4 GLU A 298
PHE A 349
VAL A 270
PHE A 296
 None
 1.17A 4a97E-4r4zA:
undetectable		 4a97E-4r4zA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rgj CALCIUM-DEPENDENT
PROTEIN KINASE 4

(Plasmodium
falciparum) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		4 GLU A 135
TYR A  70
VAL A  64
PHE A 137
 None
 1.15A 4a97E-4rgjA:
2.1		 4a97E-4rgjA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4thi PROTEIN (THIAMINASE
I)

(Bacillus
subtilis) 		PF01547
(SBP_bac_1) 		4 GLU A  43
PHE A  44
HIS A 282
VAL A 276
 None
None
SO4  A 372 (-3.7A)
None
 1.17A 4a97E-4thiA:
undetectable		 4a97E-4thiA:
22.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4twf CYS-LOOP
LIGAND-GATED ION
CHANNEL

(Dickeya
chrysanthemi) 		PF02931
(Neur_chan_LBD) 		4 GLU A 131
PHE A 133
TYR A 175
PHE A 188
 BR7  A 401 (-4.1A)
BR7  A 401 (-4.5A)
BR7  A 401 (-3.9A)
BR7  A 401 (-3.9A)
 0.55A 4a97E-4twfA:
33.7		 4a97E-4twfA:
99.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y07 NEDD4-LIKE E3
UBIQUITIN-PROTEIN
LIGASE WWP2

(Homo sapiens) 		PF00632
(HECT) 		4 GLU A 526
TYR A 604
HIS A 601
PHE A 525
 None
 1.19A 4a97E-4y07A:
undetectable		 4a97E-4y07A:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y63 HISTO-BLOOD GROUP
ABO SYSTEM
TRANSFERASE

(Homo sapiens) 		PF03414
(Glyco_transf_6) 		4 GLU A 138
PHE A 133
HIS A 145
VAL A 204
 None
 1.19A 4a97E-4y63A:
undetectable		 4a97E-4y63A:
21.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4yeu CYS-LOOP
LIGAND-GATED ION
CHANNEL,PROTON-GATED
ION CHANNEL

(Dickeya
chrysanthemi;
Gloeobacter
violaceus) 		PF02931
(Neur_chan_LBD) 		5 GLU A 131
PHE A 133
TYR A 175
HIS A 177
PHE A 188
 None
 0.63A 4a97E-4yeuA:
29.4		 4a97E-4yeuA:
71.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zyn E3 UBIQUITIN-PROTEIN
LIGASE PARKIN

(Rattus
norvegicus) 		PF00240
(ubiquitin)
PF01485
(IBR) 		4 PHE A 208
HIS A 461
VAL A 465
PHE A 210
 None
ZN  A 508 (-3.5A)
None
None
 1.14A 4a97E-4zynA:
undetectable		 4a97E-4zynA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5an9 60S RIBOSOMAL
PROTEIN L23
60S RIBOSOMAL
PROTEIN L24

(Dictyostelium
discoideum) 		PF00238
(Ribosomal_L14)
PF01246
(Ribosomal_L24e) 		4 GLU G  37
PHE G  40
TYR E  94
VAL E 136
 G  N3388 ( 3.8A)
None
None
None
 1.16A 4a97E-5an9G:
undetectable		 4a97E-5an9G:
8.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bmo PUTATIVE
UNCHARACTERIZED
PROTEIN LNMX

(Streptomyces
atroolivaceus) 		PF02585
(PIG-L) 		4 GLU A 161
PHE A 155
HIS A  88
VAL A  48
 None
 1.12A 4a97E-5bmoA:
undetectable		 4a97E-5bmoA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c5b DCC-INTERACTING
PROTEIN 13-BETA

(Homo sapiens) 		PF00169
(PH)
PF16746
(BAR_3) 		4 TYR B  88
HIS B  87
VAL B  82
PHE B 225
 None
 1.19A 4a97E-5c5bB:
5.3		 4a97E-5c5bB:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c7m E3 UBIQUITIN-PROTEIN
LIGASE ITCHY HOMOLOG

(Homo sapiens) 		PF00632
(HECT) 		4 GLU A 559
TYR A 637
HIS A 634
PHE A 558
 None
 1.19A 4a97E-5c7mA:
undetectable		 4a97E-5c7mA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c7m E3 UBIQUITIN-PROTEIN
LIGASE ITCHY HOMOLOG

(Homo sapiens) 		PF00632
(HECT) 		4 GLU A 559
TYR A 637
HIS A 634
PHE A 562
 None
 1.02A 4a97E-5c7mA:
undetectable		 4a97E-5c7mA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dqf SERUM ALBUMIN

(Equus caballus) 		PF00273
(Serum_albumin) 		4 GLU A 229
PHE A 222
TYR A 262
VAL A 240
 None
 0.88A 4a97E-5dqfA:
3.2		 4a97E-5dqfA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dux GALECTIN-4

(Homo sapiens) 		no annotation 4 TYR B 112
HIS B 111
VAL B 115
PHE B  50
 None
 1.11A 4a97E-5duxB:
undetectable		 4a97E-5duxB:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fav CHOLINE
TRIMETHYLAMINE-LYASE

(Desulfovibrio
alaskensis) 		PF01228
(Gly_radical)
PF02901
(PFL-like) 		4 GLU A 828
TYR A 428
VAL A 425
PHE A 825
 None
 0.95A 4a97E-5favA:
undetectable		 4a97E-5favA:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ghk SERUM ALBUMIN

(Canis lupus) 		PF00273
(Serum_albumin) 		4 GLU A 230
PHE A 223
TYR A 263
VAL A 241
 None
 0.85A 4a97E-5ghkA:
2.8		 4a97E-5ghkA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hpk E3 UBIQUITIN-PROTEIN
LIGASE NEDD4-LIKE

(Homo sapiens) 		PF00632
(HECT) 		4 GLU A 609
TYR A 689
HIS A 686
PHE A 608
 None
 1.20A 4a97E-5hpkA:
undetectable		 4a97E-5hpkA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i1f UTP--GLUCOSE-1-PHOSP
HATE
URIDYLYLTRANSFERASE

(Burkholderia
vietnamiensis) 		PF00483
(NTP_transferase) 		4 GLU A 161
PHE A 202
TYR A 249
VAL A 149
 None
 1.16A 4a97E-5i1fA:
undetectable		 4a97E-5i1fA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i8k HHH1 FAB HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		5 GLU H   2
TYR H  32
HIS H  33
VAL H  76
PHE H  27
 None
 1.34A 4a97E-5i8kH:
undetectable		 4a97E-5i8kH:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m99 ALPHA-AMYLASE

(Thermotoga
petrophila) 		PF00128
(Alpha-amylase) 		4 GLU B 302
PHE B 310
TYR B 336
PHE B 309
 None
 1.19A 4a97E-5m99B:
undetectable		 4a97E-5m99B:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m9o STAPHYLOCOCCAL
NUCLEASE
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF00565
(SNase)
PF00567
(TUDOR) 		4 GLU A 751
HIS A 695
VAL A 698
PHE A 762
 None
 1.01A 4a97E-5m9oA:
undetectable		 4a97E-5m9oA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nz7 CELLODEXTRIN
PHOSPHORYLASE

(Ruminiclostridium
thermocellum) 		PF06165
(Glyco_transf_36)
PF17167
(Glyco_hydro_36) 		4 GLU A 922
PHE A 459
TYR A 847
VAL A 853
 None
 1.09A 4a97E-5nz7A:
2.7		 4a97E-5nz7A:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ojj UBIQUITIN-CONJUGATIN
G ENZYME E2 T

(Homo sapiens) 		PF00179
(UQ_con) 		4 GLU A 131
TYR A  75
HIS A 150
PHE A 139
 None
 1.07A 4a97E-5ojjA:
undetectable		 4a97E-5ojjA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t1p ABC TRANSPORTER,
PERIPLASMIC
SUBSTRATE-BINDING
PROTEIN

(Campylobacter
jejuni) 		PF13343
(SBP_bac_6) 		4 GLU A 276
PHE A 277
TYR A 112
HIS A 299
 None
 1.20A 4a97E-5t1pA:
undetectable		 4a97E-5t1pA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5td7 ZGC:55652

(Danio rerio) 		PF00850
(Hist_deacetyl) 		4 GLU A  28
TYR A  16
HIS A 103
VAL A  74
 None
 1.22A 4a97E-5td7A:
undetectable		 4a97E-5td7A:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u4r VRC 315 53-1A09 FAB
HEAVY CHAIN

(Homo sapiens) 		no annotation 4 TYR A  32
HIS A  33
VAL A  78
PHE A  27
 None
 0.91A 4a97E-5u4rA:
undetectable		 4a97E-5u4rA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v9p LYSINE-SPECIFIC
DEMETHYLASE 5A

(Homo sapiens) 		PF00628
(PHD)
PF01388
(ARID)
PF02373
(JmjC)
PF02375
(JmjN)
PF02928
(zf-C5HC2)
PF08429
(PLU-1) 		4 GLU A 614
PHE A 666
HIS A 702
VAL A 653
 None
None
ZN  A 902 (-3.8A)
None
 1.11A 4a97E-5v9pA:
3.3		 4a97E-5v9pA:
16.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vkq NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L

(Drosophila
melanogaster) 		PF00023
(Ank)
PF00520
(Ion_trans)
PF12796
(Ank_2)
PF13637
(Ank_4) 		4 GLU A1120
PHE A1116
HIS A1054
VAL A1092
 None
 1.18A 4a97E-5vkqA:
3.4		 4a97E-5vkqA:
10.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5voc ENVELOPE
GLYCOPROTEIN H

(Human
betaherpesvirus
5) 		PF02489
(Herpes_glycop_H)
PF17488
(Herpes_glycoH_C) 		4 GLU A 339
PHE A 342
VAL A 128
PHE A 297
 None
 1.17A 4a97E-5vocA:
3.6		 4a97E-5vocA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wa2 SURFACE ANTIGEN

(Toxoplasma
gondii) 		no annotation 4 GLU A  79
TYR A 191
HIS A 189
PHE A 193
 None
 1.10A 4a97E-5wa2A:
undetectable		 4a97E-5wa2A:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wq3 CYTOKININ RIBOSIDE
5'-MONOPHOSPHATE
PHOSPHORIBOHYDROLASE

(Corynebacterium
glutamicum) 		PF03641
(Lysine_decarbox) 		4 GLU A  56
PHE A  61
VAL A 104
PHE A 149
 1PE  A 301 ( 4.5A)
None
None
1PE  A 301 ( 4.8A)
 1.21A 4a97E-5wq3A:
undetectable		 4a97E-5wq3A:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xmc E3 UBIQUITIN-PROTEIN
LIGASE ITCHY

(Mus musculus) 		PF00397
(WW)
PF00632
(HECT) 		4 GLU A 520
TYR A 598
HIS A 595
PHE A 519
 None
 1.11A 4a97E-5xmcA:
2.4		 4a97E-5xmcA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xmc E3 UBIQUITIN-PROTEIN
LIGASE ITCHY

(Mus musculus) 		PF00397
(WW)
PF00632
(HECT) 		4 GLU A 520
TYR A 598
HIS A 595
PHE A 523
 None
 1.04A 4a97E-5xmcA:
2.4		 4a97E-5xmcA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xya -

(-) 		no annotation 4 TYR A 610
HIS A 609
VAL A 565
PHE A 301
 None
 1.17A 4a97E-5xyaA:
undetectable		 4a97E-5xyaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cp2 -

(-) 		no annotation 4 GLU B 128
TYR B  75
VAL B 112
PHE B 136
 None
 1.17A 4a97E-6cp2B:
undetectable		 4a97E-6cp2B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fkh ATP SYNTHASE SUBUNIT
BETA, CHLOROPLASTIC

(Spinacia
oleracea) 		no annotation 4 GLU D 150
PHE D 149
TYR D 448
VAL D 437
 None
 1.13A 4a97E-6fkhD:
2.4		 4a97E-6fkhD:
18.40