SIMILAR PATTERNS OF AMINO ACIDS FOR 4A97_D_ZPCD1318_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1air PECTATE LYASE C

(Dickeya
chrysanthemi) 		PF00544
(Pec_lyase_C) 		4 PHE A 103
VAL A  82
ILE A  33
GLU A  60
 None
 1.05A 4a97C-1airA:
undetectable		 4a97C-1airA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bf6 PHOSPHOTRIESTERASE
HOMOLOGY PROTEIN

(Escherichia
coli) 		PF02126
(PTE) 		4 PHE A   3
VAL A  78
ARG A 153
ILE A 122
 None
 1.03A 4a97C-1bf6A:
0.0		 4a97C-1bf6A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f82 BOTULINUM NEUROTOXIN
TYPE B

(Clostridium
botulinum) 		PF01742
(Peptidase_M27) 		4 PHE A 154
VAL A 135
ARG A  27
ILE A 132
 None
 0.92A 4a97C-1f82A:
0.0		 4a97C-1f82A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kfu M-CALPAIN LARGE
SUBUNIT

(Homo sapiens) 		PF00648
(Peptidase_C2)
PF01067
(Calpain_III)
PF13833
(EF-hand_8) 		4 PHE L 475
VAL L 409
ILE L 499
GLU L 460
 None
 0.91A 4a97C-1kfuL:
0.0		 4a97C-1kfuL:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1knr L-ASPARTATE OXIDASE

(Escherichia
coli) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C) 		4 PHE A 446
TYR A 450
MET A 505
GLU A 442
 None
 1.11A 4a97C-1knrA:
6.3		 4a97C-1knrA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l1l RIBONUCLEOSIDE
TRIPHOSPHATE
REDUCTASE

(Lactobacillus
leichmannii) 		PF02867
(Ribonuc_red_lgC) 		4 PHE A 165
VAL A 167
ILE A 172
GLU A 322
 None
 1.05A 4a97C-1l1lA:
1.7		 4a97C-1l1lA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nba N-CARBAMOYLSARCOSINE
AMIDOHYDROLASE

(Arthrobacter
sp.) 		PF00857
(Isochorismatase) 		4 VAL A  75
MET A  68
ILE A  71
GLU A 139
 None
 0.90A 4a97C-1nbaA:
undetectable		 4a97C-1nbaA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nt2 FIBRILLARIN-LIKE
PRE-RRNA PROCESSING
PROTEIN

(Archaeoglobus
fulgidus) 		PF01269
(Fibrillarin) 		4 TYR A 208
VAL A 157
ILE A 130
GLU A 184
 None
 1.06A 4a97C-1nt2A:
0.0		 4a97C-1nt2A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o12 N-ACETYLGLUCOSAMINE-
6-PHOSPHATE
DEACETYLASE

(Thermotoga
maritima) 		PF01979
(Amidohydro_1) 		4 TYR A 319
VAL A 316
ILE A 250
ASN A 320
 None
 1.03A 4a97C-1o12A:
0.0		 4a97C-1o12A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qdl PROTEIN
(ANTHRANILATE
SYNTHASE
(TRPE-SUBUNIT))

(Sulfolobus
solfataricus) 		PF00425
(Chorismate_bind)
PF04715
(Anth_synt_I_N) 		4 TYR A  41
VAL A  43
ILE A 118
GLU A 371
 None
 1.07A 4a97C-1qdlA:
undetectable		 4a97C-1qdlA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tvm PTS SYSTEM,
GALACTITOL-SPECIFIC
IIB COMPONENT

(Escherichia
coli) 		PF02302
(PTS_IIB) 		4 PHE A  17
TYR A  16
ASN A  14
GLU A  54
 None
 0.98A 4a97C-1tvmA:
undetectable		 4a97C-1tvmA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1twd COPPER HOMEOSTASIS
PROTEIN CUTC

(Shigella
flexneri) 		PF03932
(CutC) 		4 VAL A 118
MET A 106
ILE A 109
GLU A   5
 None
 1.08A 4a97C-1twdA:
undetectable		 4a97C-1twdA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xew SMC PROTEIN

(Pyrococcus
furiosus) 		PF02463
(SMC_N) 		4 PHE X  12
TYR X  15
VAL X  82
ILE X  84
 None
 0.92A 4a97C-1xewX:
undetectable		 4a97C-1xewX:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xmx HYPOTHETICAL PROTEIN
VC1899

(Vibrio cholerae) 		PF09002
(DUF1887) 		4 PHE A 106
TYR A 109
VAL A  87
ILE A   3
 None
 1.02A 4a97C-1xmxA:
undetectable		 4a97C-1xmxA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yal CHYMOPAPAIN

(Carica papaya) 		PF00112
(Peptidase_C1) 		4 VAL A 161
MET A 191
ILE A 177
ASN A 179
 None
 0.85A 4a97C-1yalA:
undetectable		 4a97C-1yalA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2az3 NUCLEOSIDE
DIPHOSPHATE KINASE

(Halobacterium
salinarum) 		PF00334
(NDK) 		4 ARG A 106
ILE A 118
ASN A 116
GLU A  55
 CDP  A1100 ( 4.8A)
None
CDP  A1100 (-3.1A)
MG  A 201 ( 2.7A)
 1.08A 4a97C-2az3A:
undetectable		 4a97C-2az3A:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e18 NH(3)-DEPENDENT
NAD(+) SYNTHETASE

(Pyrococcus
horikoshii) 		PF02540
(NAD_synthase) 		4 TYR A 197
VAL A 161
ILE A 153
ASN A 131
 None
None
None
ZN  A1305 ( 4.9A)
 0.99A 4a97C-2e18A:
undetectable		 4a97C-2e18A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eaa 7S GLOBULIN-3

(Vigna angularis) 		PF00190
(Cupin_1) 		4 PHE A  47
TYR A  60
VAL A  62
ILE A 134
 None
 0.88A 4a97C-2eaaA:
undetectable		 4a97C-2eaaA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iuy GLYCOSYLTRANSFERASE

(Streptomyces
viridochromogenes) 		PF00534
(Glycos_transf_1) 		4 TYR A  39
VAL A 230
ILE A 227
GLU A 270
 None
MES  A1353 (-3.4A)
None
None
 1.05A 4a97C-2iuyA:
undetectable		 4a97C-2iuyA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2okx RHAMNOSIDASE B

(Bacillus sp.
GL1) 		PF05592
(Bac_rhamnosid)
PF08531
(Bac_rhamnosid_N)
PF17389
(Bac_rhamnosid6H)
PF17390
(Bac_rhamnosid_C) 		4 PHE A 806
ILE A 626
ASN A 628
GLU A 809
 None
 1.10A 4a97C-2okxA:
3.7		 4a97C-2okxA:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qjt NICOTINAMIDE-NUCLEOT
IDE
ADENYLYLTRANSFERASE

(Francisella
tularensis) 		no annotation 4 PHE B  51
ILE B  33
ASN B  94
GLU B  52
 None
 1.07A 4a97C-2qjtB:
undetectable		 4a97C-2qjtB:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qn0 NEUROTOXIN

(Clostridium
botulinum) 		PF01742
(Peptidase_M27) 		4 TYR A 202
VAL A 379
ILE A 256
GLU A 360
 None
 0.89A 4a97C-2qn0A:
undetectable		 4a97C-2qn0A:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qqp LARGE CAPSID PROTEIN

(Providence
virus) 		PF03566
(Peptidase_A21) 		4 PHE A 458
VAL A 405
ILE A 263
ASN A 406
 None
 1.08A 4a97C-2qqpA:
undetectable		 4a97C-2qqpA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r6f EXCINUCLEASE ABC
SUBUNIT A

(Geobacillus
stearothermophilus) 		PF00005
(ABC_tran) 		4 TYR A 315
VAL A 375
ILE A 376
ASN A 378
 None
 1.07A 4a97C-2r6fA:
undetectable		 4a97C-2r6fA:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uut RNA-DIRECTED RNA
POLYMERASE

(Sapporo virus) 		PF00680
(RdRP_1) 		4 PHE A 337
TYR A  90
VAL A  87
ILE A 261
 None
 1.10A 4a97C-2uutA:
undetectable		 4a97C-2uutA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yqu 2-OXOGLUTARATE
DEHYDROGENASE E3
COMPONENT

(Thermus
thermophilus) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 TYR A 265
VAL A 303
ILE A 284
GLU A  31
 FAD  A1601 (-4.8A)
None
None
FAD  A1601 (-2.7A)
 0.87A 4a97C-2yquA:
2.3		 4a97C-2yquA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z3k LEUCYL/PHENYLALANYL-
TRNA-PROTEIN
TRANSFERASE

(Escherichia
coli) 		PF03588
(Leu_Phe_trans) 		4 TYR A  87
VAL A  89
MET A 144
ILE A 132
 None
None
PHE  A 302 ( 3.6A)
None
 0.72A 4a97C-2z3kA:
undetectable		 4a97C-2z3kA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zi8 PROBABLE
BIPHENYL-2,3-DIOL
1,2-DIOXYGENASE BPHC

(Mycobacterium
tuberculosis) 		PF00903
(Glyoxalase) 		4 PHE A 136
VAL A 218
MET A 257
ILE A 265
 None
 0.96A 4a97C-2zi8A:
undetectable		 4a97C-2zi8A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3al8 SEMAPHORIN-6A

(Mus musculus) 		PF01403
(Sema)
PF01437
(PSI) 		4 PHE A 291
TYR A 292
ILE A 295
ASN A 294
 None
 1.09A 4a97C-3al8A:
undetectable		 4a97C-3al8A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dg8 BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE

(Plasmodium
falciparum) 		PF00186
(DHFR_1) 		4 VAL A 140
MET A 104
ILE A 126
ASN A 124
 None
RJ6  A 609 ( 4.0A)
None
None
 0.99A 4a97C-3dg8A:
undetectable		 4a97C-3dg8A:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3doo SHIKIMATE
DEHYDROGENASE

(Staphylococcus
epidermidis) 		PF01488
(Shikimate_DH)
PF08501
(Shikimate_dh_N) 		4 TYR A  97
VAL A  84
ILE A  67
GLU A  76
 None
 0.93A 4a97C-3dooA:
undetectable		 4a97C-3dooA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dwl ACTIN-RELATED
PROTEIN 2/3 COMPLEX
SUBUNIT 4

(Schizosaccharomyces
pombe) 		PF05856
(ARPC4) 		4 PHE F 138
VAL F 142
MET F 149
ILE F 146
 None
 1.10A 4a97C-3dwlF:
undetectable		 4a97C-3dwlF:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dzu PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep)
PF00105
(zf-C4) 		4 PHE D 368
VAL D 339
ILE D 341
GLU D 365
 None
None
PLB  D 701 (-3.6A)
None
 1.10A 4a97C-3dzuD:
0.9		 4a97C-3dzuD:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ejg NON-STRUCTURAL
PROTEIN 3

(Human
coronavirus
229E) 		PF01661
(Macro) 		4 PHE A   6
TYR A  15
VAL A 150
ILE A 120
 None
 0.99A 4a97C-3ejgA:
undetectable		 4a97C-3ejgA:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ele AMINO TRANSFERASE

([Eubacterium]
rectale) 		PF00155
(Aminotran_1_2) 		4 TYR A 219
ILE A 177
ASN A 178
GLU A 221
 PLP  A 500 (-4.4A)
None
PLP  A 500 (-3.0A)
EDO  A 501 ( 3.8A)
 0.94A 4a97C-3eleA:
undetectable		 4a97C-3eleA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3erv PUTATIVE C39-LIKE
PEPTIDASE

(Bacillus
anthracis) 		PF13529
(Peptidase_C39_2) 		4 TYR A 207
VAL A 212
ILE A 214
GLU A 155
 None
 1.11A 4a97C-3ervA:
undetectable		 4a97C-3ervA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ewr NON-STRUCTURAL
PROTEIN 3

(Human
coronavirus
229E) 		PF01661
(Macro) 		4 PHE A   7
TYR A  16
VAL A 151
ILE A 121
 None
None
APR  A 169 ( 4.6A)
None
 0.94A 4a97C-3ewrA:
undetectable		 4a97C-3ewrA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fmq METHIONINE
AMINOPEPTIDASE 2

(Encephalitozoon
cuniculi) 		PF00557
(Peptidase_M24) 		4 PHE A 148
VAL A 146
MET A 101
ILE A 129
 None
 1.07A 4a97C-3fmqA:
0.6		 4a97C-3fmqA:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gpg NON-STRUCTURAL
PROTEIN 3

(Chikungunya
virus) 		PF01661
(Macro) 		4 VAL A  19
ILE A  11
ASN A  14
GLU A  43
 None
 1.06A 4a97C-3gpgA:
undetectable		 4a97C-3gpgA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hur ALANINE RACEMASE

(Oenococcus oeni) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		4 VAL A 252
ARG A 371
ILE A 369
GLU A 343
 None
 1.11A 4a97C-3hurA:
undetectable		 4a97C-3hurA:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ib5 SEX PHEROMONE
PRECURSOR

(Lactobacillus
salivarius) 		PF07537
(CamS) 		4 TYR A 146
VAL A 147
MET A 227
ILE A 172
 None
 0.85A 4a97C-3ib5A:
undetectable		 4a97C-3ib5A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j82 C-TYPE LECTIN DOMAIN
FAMILY 9 MEMBER A

(Mus musculus) 		PF00059
(Lectin_C) 		4 TYR A 236
VAL A 198
MET A 181
ILE A 175
 None
 1.07A 4a97C-3j82A:
undetectable		 4a97C-3j82A:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jbh MYOSIN 2 HEAVY CHAIN
STRIATED MUSCLE

(Aphonopelma) 		PF00063
(Myosin_head)
PF01576
(Myosin_tail_1)
PF02736
(Myosin_N) 		4 PHE A 338
TYR A 342
VAL A 346
ILE A 349
 None
 0.99A 4a97C-3jbhA:
undetectable		 4a97C-3jbhA:
9.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ll9 ISOPENTENYL
PHOSPHATE KINASE

(Methanothermobacter
thermautotrophicus) 		PF00696
(AA_kinase) 		4 VAL A  10
ARG A  28
ILE A  29
ASN A  25
 None
 1.04A 4a97C-3ll9A:
1.2		 4a97C-3ll9A:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ml6 CHIMERIC COMPLEX
BETWEEN PROTEIN
DISHEVLLED2 HOMOLOG
DVL-2 AND CLATHRIN
ADAPTOR AP-2 COMPLEX
SUBUNIT MU

(Mus musculus;
Rattus
norvegicus) 		PF00610
(DEP)
PF00928
(Adap_comp_sub) 		4 PHE A 469
TYR A 463
VAL A 466
MET A 430
 None
 0.95A 4a97C-3ml6A:
undetectable		 4a97C-3ml6A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p8s JACALIN

(Artocarpus
heterophyllus) 		PF01419
(Jacalin) 		4 PHE A 128
TYR A  95
VAL A 105
ILE A  49
 None
 1.08A 4a97C-3p8sA:
undetectable		 4a97C-3p8sA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pco PHENYLALANYL-TRNA
SYNTHETASE, BETA
CHAIN

(Escherichia
coli) 		PF01588
(tRNA_bind)
PF03147
(FDX-ACB)
PF03483
(B3_4)
PF03484
(B5) 		4 VAL B 250
ILE B 246
ASN B 254
GLU B 334
 None
 1.07A 4a97C-3pcoB:
undetectable		 4a97C-3pcoB:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pg7 NEUROFIBROMIN

(Homo sapiens) 		PF13716
(CRAL_TRIO_2) 		4 PHE A1719
VAL A1736
ILE A1805
GLU A1794
 None
 1.01A 4a97C-3pg7A:
undetectable		 4a97C-3pg7A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3um6 BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE

(Plasmodium
falciparum) 		PF00186
(DHFR_1)
PF00303
(Thymidylat_synt) 		4 VAL A 140
MET A 104
ILE A 126
ASN A 124
 None
1CY  A 609 ( 4.5A)
None
None
 0.83A 4a97C-3um6A:
undetectable		 4a97C-3um6A:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v9e LACCASE

(Botrytis aclada) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 PHE A 393
TYR A 397
VAL A 399
GLU A 390
 None
 1.10A 4a97C-3v9eA:
undetectable		 4a97C-3v9eA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vtz GLUCOSE
1-DEHYDROGENASE

(Thermoplasma
volcanium) 		PF13561
(adh_short_C2) 		4 TYR A 109
VAL A 105
ILE A 101
ASN A 106
 None
 0.86A 4a97C-3vtzA:
undetectable		 4a97C-3vtzA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vys HYDROGENASE
EXPRESSION/FORMATION
PROTEIN HYPD

(Thermococcus
kodakarensis) 		PF01924
(HypD) 		4 VAL B  58
ILE B  32
ASN B  57
GLU B  19
 None
 0.98A 4a97C-3vysB:
undetectable		 4a97C-3vysB:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wcy INTERFERON
ALPHA/BETA RECEPTOR
1

(Mus musculus) 		PF01108
(Tissue_fac)
PF09294
(Interfer-bind) 		4 TYR A 370
VAL A 372
MET A 352
ILE A 339
 None
 0.88A 4a97C-3wcyA:
undetectable		 4a97C-3wcyA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wiq KOJIBIOSE
PHOSPHORYLASE

(Caldicellulosiruptor
saccharolyticus) 		PF03632
(Glyco_hydro_65m)
PF03633
(Glyco_hydro_65C)
PF03636
(Glyco_hydro_65N) 		4 PHE A 655
VAL A 307
ILE A 311
ASN A 310
 None
 0.93A 4a97C-3wiqA:
3.0		 4a97C-3wiqA:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wr7 SPERMIDINE
N1-ACETYLTRANSFERASE

(Escherichia
coli) 		PF13302
(Acetyltransf_3) 		4 TYR A  30
VAL A 122
ILE A 130
ASN A 126
 COA  A 202 (-3.4A)
COA  A 202 ( 4.8A)
None
COA  A 202 ( 4.7A)
 1.05A 4a97C-3wr7A:
undetectable		 4a97C-3wr7A:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bih UNCHARACTERIZED
LIPOPROTEIN
SAOUHSC_00053

(Staphylococcus
aureus) 		PF04507
(DUF576) 		4 TYR A 125
VAL A 127
ILE A 134
GLU A 122
 None
 1.06A 4a97C-4bihA:
undetectable		 4a97C-4bihA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c1n IRON-SULFUR CLUSTER
BINDING PROTEIN

(Carboxydothermus
hydrogenoformans) 		PF14574
(DUF4445) 		4 VAL I 538
MET I 384
ILE I 376
GLU I 533
 None
 1.06A 4a97C-4c1nI:
undetectable		 4a97C-4c1nI:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c8q DNA TOPOISOMERASE
2-ASSOCIATED PROTEIN
PAT1

(Saccharomyces
cerevisiae) 		PF09770
(PAT1) 		4 PHE H 681
VAL H 727
ILE H 724
GLU H 701
 None
None
None
CO  H1080 (-3.8A)
 1.08A 4a97C-4c8qH:
1.5		 4a97C-4c8qH:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4crn ERF1 IN
RIBOSOME-BOUND
ERF1-ERF3-GDPNP
COMPLEX

(Saccharomyces
cerevisiae) 		PF03463
(eRF1_1)
PF03464
(eRF1_2)
PF03465
(eRF1_3) 		4 TYR X 277
VAL X   5
ILE X 387
ASN X   8
 None
 1.09A 4a97C-4crnX:
undetectable		 4a97C-4crnX:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eg9 UNCHARACTERIZED
PROTEIN
SAOUHSC_02783

(Staphylococcus
aureus) 		PF04507
(DUF576) 		4 VAL A  95
ILE A  75
ASN A  77
GLU A 126
 None
 0.74A 4a97C-4eg9A:
undetectable		 4a97C-4eg9A:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f92 U5 SMALL NUCLEAR
RIBONUCLEOPROTEIN
200 KDA HELICASE

(Homo sapiens) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF02889
(Sec63) 		4 VAL B1099
MET B1092
ILE B1095
GLU B1226
 None
 1.07A 4a97C-4f92B:
undetectable		 4a97C-4f92B:
10.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fyc THIOL:DISULFIDE
INTERCHANGE PROTEIN
(DSBC)

(Helicobacter
pylori) 		PF13098
(Thioredoxin_2) 		4 PHE A  67
TYR A 116
VAL A  83
ILE A 158
 None
 0.99A 4a97C-4fycA:
undetectable		 4a97C-4fycA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iug BETA-GALACTOSIDASE A

(Aspergillus
oryzae) 		PF01301
(Glyco_hydro_35)
PF10435
(BetaGal_dom2)
PF13363
(BetaGal_dom3)
PF13364
(BetaGal_dom4_5) 		4 TYR A 957
VAL A 925
ILE A 949
ASN A 926
 None
 1.10A 4a97C-4iugA:
undetectable		 4a97C-4iugA:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k91 D-ALA-D-ALA-CARBOXYP
EPTIDASE

(Pseudomonas
aeruginosa) 		PF00768
(Peptidase_S11)
PF07943
(PBP5_C) 		4 PHE A 230
VAL A 228
MET A  20
ILE A 226
 None
 1.06A 4a97C-4k91A:
undetectable		 4a97C-4k91A:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p27 VENOM ALLERGEN-LIKE
(VAL) 4 PROTEIN

(Schistosoma
mansoni) 		PF00188
(CAP) 		4 PHE A  14
VAL A  18
ILE A  27
GLU A  85
 None
 1.06A 4a97C-4p27A:
undetectable		 4a97C-4p27A:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p68 DIHYDROFOLATE
REDUCTASE

(Escherichia
coli) 		PF00186
(DHFR_1) 		4 VAL A  72
MET A  42
ILE A  61
ASN A  59
 None
None
None
XCN  A  54 ( 3.0A)
 0.84A 4a97C-4p68A:
undetectable		 4a97C-4p68A:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pvc NADPH-DEPENDENT
METHYLGLYOXAL
REDUCTASE GRE2

(Saccharomyces
cerevisiae) 		PF01073
(3Beta_HSD) 		4 VAL A 101
ILE A  98
ASN A 102
GLU A 182
 None
 1.07A 4a97C-4pvcA:
undetectable		 4a97C-4pvcA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q8k ALGINASE

(Pseudoalteromonas
sp. SM0524) 		PF08787
(Alginate_lyase2) 		4 PHE A 239
TYR A 395
VAL A 393
ILE A 175
 None
 1.01A 4a97C-4q8kA:
undetectable		 4a97C-4q8kA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q8l ALGINASE

(Pseudoalteromonas
sp. SM0524) 		PF08787
(Alginate_lyase2) 		4 PHE A  72
TYR A 228
VAL A 226
ILE A   8
 None
 0.99A 4a97C-4q8lA:
undetectable		 4a97C-4q8lA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qni UNCHARACTERIZED
PROTEIN

(Bacteroides
thetaiotaomicron) 		PF14274
(DUF4361)
PF16343
(DUF4973) 		4 TYR A 328
VAL A 330
ILE A 200
ASN A 202
 None
None
EDO  A 403 ( 4.1A)
EDO  A 403 ( 4.9A)
 1.00A 4a97C-4qniA:
undetectable		 4a97C-4qniA:
20.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4twf CYS-LOOP
LIGAND-GATED ION
CHANNEL

(Dickeya
chrysanthemi) 		PF02931
(Neur_chan_LBD) 		6 PHE A  19
TYR A  38
VAL A  40
ARG A  91
MET A  93
ILE A 101
 None
 0.55A 4a97C-4twfA:
33.8		 4a97C-4twfA:
99.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4twf CYS-LOOP
LIGAND-GATED ION
CHANNEL

(Dickeya
chrysanthemi) 		PF02931
(Neur_chan_LBD) 		5 PHE A  19
VAL A  40
ARG A  91
MET A  93
ASN A 103
 None
 0.90A 4a97C-4twfA:
33.8		 4a97C-4twfA:
99.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4unw H3 HAEMAGGLUTININ
HA1 CHAIN

(Influenza A
virus) 		PF00509
(Hemagglutinin) 		4 TYR A  56
VAL A  58
MET A 268
ILE A  88
 None
 0.95A 4a97C-4unwA:
undetectable		 4a97C-4unwA:
22.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4yeu CYS-LOOP
LIGAND-GATED ION
CHANNEL,PROTON-GATED
ION CHANNEL

(Dickeya
chrysanthemi;
Gloeobacter
violaceus) 		PF02931
(Neur_chan_LBD) 		7 PHE A  19
TYR A  38
VAL A  40
ARG A  91
MET A  93
ILE A 101
ASN A 103
 None
 0.64A 4a97C-4yeuA:
29.4		 4a97C-4yeuA:
71.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cmn LATROPHILIN-3

(Homo sapiens) 		PF02191
(OLF) 		4 PHE E 314
VAL E 367
ILE E 364
ASN E 312
 None
CA  E 401 (-4.8A)
None
CA  E 401 (-3.3A)
 1.01A 4a97C-5cmnE:
undetectable		 4a97C-5cmnE:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5czz CRISPR-ASSOCIATED
ENDONUCLEASE CAS9

(Staphylococcus
aureus) 		PF13395
(HNH_4)
PF16592
(Cas9_REC) 		4 ARG A 980
ILE A 982
ASN A 995
GLU A1006
 None
 1.05A 4a97C-5czzA:
undetectable		 4a97C-5czzA:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dxv RETHREADED DHFR

(synthetic
construct) 		PF00186
(DHFR_1) 		4 VAL A  89
MET A  59
ILE A  78
ASN A  76
 None
 0.79A 4a97C-5dxvA:
undetectable		 4a97C-5dxvA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e9o CELLULASE, GLYCOSYL
HYDROLASE FAMILY 5,
TPS LINKER, DOMAIN X

(Spirochaeta
thermophila) 		no annotation 4 TYR A 526
ILE A 517
ASN A 503
GLU A 461
 None
 0.90A 4a97C-5e9oA:
undetectable		 4a97C-5e9oA:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5flz SPINDLE POLE BODY
COMPONENT SPC98

(Saccharomyces
cerevisiae) 		PF04130
(Spc97_Spc98) 		4 TYR B 187
VAL B 188
ILE B 224
GLU B 182
 None
 1.05A 4a97C-5flzB:
undetectable		 4a97C-5flzB:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fno MANGANESE
LIPOXYGENASE

(Magnaporthe
oryzae) 		PF00305
(Lipoxygenase) 		4 VAL A 573
MET A 566
ILE A 569
GLU A 476
 None
 1.06A 4a97C-5fnoA:
undetectable		 4a97C-5fnoA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ftt ADHESION G
PROTEIN-COUPLED
RECEPTOR L3

(Mus musculus) 		PF02140
(Gal_Lectin)
PF02191
(OLF) 		4 PHE C 382
VAL C 435
ILE C 432
ASN C 380
 None
CA  C1467 (-4.8A)
None
CA  C1467 (-3.7A)
 1.03A 4a97C-5fttC:
undetectable		 4a97C-5fttC:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ii5 MALTOSE-BINDING
PERIPLASMIC
PROTEIN,VITELLINE
ENVELOPE SPERM LYSIN
RECEPTOR

(Escherichia
coli;
Haliotis
rufescens) 		PF11386
(VERL)
PF13416
(SBP_bac_8) 		4 PHE A4106
VAL A4123
MET A4077
ILE A4070
 None
 0.79A 4a97C-5ii5A:
undetectable		 4a97C-5ii5A:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l0l UNCHARACTERIZED
PROTEIN

(Legionella
pneumophila) 		no annotation 4 TYR A 130
VAL A 132
MET A 224
ILE A 144
 None
 0.70A 4a97C-5l0lA:
undetectable		 4a97C-5l0lA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lmg DNA TOPOISOMERASE
2-ASSOCIATED PROTEIN
PAT1

(Saccharomyces
cerevisiae) 		PF09770
(PAT1) 		4 PHE A 681
VAL A 727
ILE A 724
GLU A 701
 None
None
None
EDO  A 804 (-2.9A)
 1.10A 4a97C-5lmgA:
undetectable		 4a97C-5lmgA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mpd 26S PROTEASOME
REGULATORY SUBUNIT
RPN6

(Saccharomyces
cerevisiae) 		PF01399
(PCI) 		4 VAL Q 302
MET Q 271
ILE Q 270
GLU Q 322
 None
 0.86A 4a97C-5mpdQ:
4.3		 4a97C-5mpdQ:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n0l GTP-SENSING
TRANSCRIPTIONAL
PLEIOTROPIC
REPRESSOR CODY

(Clostridioides
difficile) 		no annotation 4 PHE A  74
TYR A  78
VAL A  82
ILE A  85
 ILE  A 201 ( 4.7A)
None
None
None
 1.01A 4a97C-5n0lA:
undetectable		 4a97C-5n0lA:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ofb MORC FAMILY CW-TYPE
ZINC FINGER PROTEIN
2

(Homo sapiens) 		no annotation 4 TYR B 418
VAL B 416
ILE B 384
ASN B 386
 None
 1.10A 4a97C-5ofbB:
undetectable		 4a97C-5ofbB:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5te1 ATP-CITRATE SYNTHASE

(Homo sapiens) 		PF00549
(Ligase_CoA)
PF02629
(CoA_binding)
PF16114
(Citrate_bind) 		4 PHE A 493
VAL A 568
ILE A 591
GLU A 683
 None
 1.02A 4a97C-5te1A:
undetectable		 4a97C-5te1A:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tet ATP-CITRATE SYNTHASE

(Homo sapiens) 		PF00549
(Ligase_CoA)
PF02629
(CoA_binding) 		4 PHE B 493
VAL B 568
ILE B 591
GLU B 683
 None
 0.99A 4a97C-5tetB:
undetectable		 4a97C-5tetB:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5trv DENOVO NTF2

(synthetic
construct) 		PF12680
(SnoaL_2) 		4 PHE A  41
VAL A  36
MET A  88
ILE A 106
 PEG  A 201 (-4.3A)
None
None
None
 0.94A 4a97C-5trvA:
undetectable		 4a97C-5trvA:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u7x NOD FACTOR BINDING
LECTIN-NUCLEOTIDE
PHOSPHOHYDROLASE

(Vigna
unguiculata) 		PF01150
(GDA1_CD39) 		4 TYR F 209
VAL F 164
ILE F 157
GLU F 185
 None
 1.10A 4a97C-5u7xF:
undetectable		 4a97C-5u7xF:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5udy ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 7

(Homo sapiens) 		PF01663
(Phosphodiest) 		4 TYR A 194
VAL A  36
ILE A 243
GLU A 171
 None
None
None
FUC  A 508 ( 4.3A)
 0.93A 4a97C-5udyA:
undetectable		 4a97C-5udyA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uwb TOLUENE TOLERANCE
PROTEIN

(Pseudomonas
putida) 		no annotation 4 TYR B 144
VAL B 164
ILE B 167
ASN B 165
 PEF  B 302 (-4.0A)
PEF  B 302 ( 4.6A)
None
PEF  B 302 ( 4.1A)
 0.94A 4a97C-5uwbB:
undetectable		 4a97C-5uwbB:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vf3 MAJOR CAPSID PROTEIN

(Escherichia
virus T4) 		PF07068
(Gp23) 		4 PHE A 434
VAL A 382
ILE A 521
GLU A 360
 None
 1.08A 4a97C-5vf3A:
undetectable		 4a97C-5vf3A:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xns CHROMOSOME PARTITION
PROTEIN SMC

(Pyrococcus
furiosus) 		PF02463
(SMC_N) 		4 PHE A  12
TYR A  15
VAL A  82
ILE A  84
 None
 0.98A 4a97C-5xnsA:
undetectable		 4a97C-5xnsA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yfb DIPEPTIDYL PEPTIDASE
3

(Armillaria
tabescens) 		no annotation 4 TYR A 313
VAL A 314
ILE A 164
GLU A 324
 None
 1.04A 4a97C-5yfbA:
undetectable		 4a97C-5yfbA:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6azt ASPARAGINYL
ENDOPEPTIDASE 1

(Helianthus
annuus) 		no annotation 4 PHE A 100
VAL A  63
MET A 213
ILE A 171
 None
 0.90A 4a97C-6aztA:
undetectable		 4a97C-6aztA:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6caa ELECTROGENIC SODIUM
BICARBONATE
COTRANSPORTER 1

(Homo sapiens) 		no annotation 4 PHE A 865
TYR A 862
VAL A 864
ILE A 692
 None
 1.04A 4a97C-6caaA:
undetectable		 4a97C-6caaA:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d46 BETA SLIDING CLAMP

(Rickettsia
typhi) 		no annotation 4 PHE A 353
TYR A 352
VAL A 362
ILE A 376
 None
 0.96A 4a97C-6d46A:
undetectable		 4a97C-6d46A:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f36 MITOCHONDRIAL ATP
SYNTHASE SUBUNIT
ASA6

(Polytomella sp.
Pringsheim
198.80) 		no annotation 4 PHE N 129
TYR N 126
VAL N 125
ILE N 120
 None
 1.11A 4a97C-6f36N:
undetectable		 4a97C-6f36N:
14.71