SIMILAR PATTERNS OF AMINO ACIDS FOR 4A97_D_ZPCD1318

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1air PECTATE LYASE C

(Dickeya
chrysanthemi) 		PF00544
(Pec_lyase_C) 		4 PHE A 103
VAL A  82
ILE A  33
GLU A  60
 None
 1.05A 4a97C-1airA:
undetectable		 4a97C-1airA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bf6 PHOSPHOTRIESTERASE
HOMOLOGY PROTEIN

(Escherichia
coli) 		PF02126
(PTE) 		4 PHE A   3
VAL A  78
ARG A 153
ILE A 122
 None
 1.03A 4a97C-1bf6A:
0.0		 4a97C-1bf6A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f82 BOTULINUM NEUROTOXIN
TYPE B

(Clostridium
botulinum) 		PF01742
(Peptidase_M27) 		4 PHE A 154
VAL A 135
ARG A  27
ILE A 132
 None
 0.92A 4a97C-1f82A:
0.0		 4a97C-1f82A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kfu M-CALPAIN LARGE
SUBUNIT

(Homo sapiens) 		PF00648
(Peptidase_C2)
PF01067
(Calpain_III)
PF13833
(EF-hand_8) 		4 PHE L 475
VAL L 409
ILE L 499
GLU L 460
 None
 0.91A 4a97C-1kfuL:
0.0		 4a97C-1kfuL:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1knr L-ASPARTATE OXIDASE

(Escherichia
coli) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C) 		4 PHE A 446
TYR A 450
MET A 505
GLU A 442
 None
 1.11A 4a97C-1knrA:
6.3		 4a97C-1knrA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l1l RIBONUCLEOSIDE
TRIPHOSPHATE
REDUCTASE

(Lactobacillus
leichmannii) 		PF02867
(Ribonuc_red_lgC) 		4 PHE A 165
VAL A 167
ILE A 172
GLU A 322
 None
 1.05A 4a97C-1l1lA:
1.7		 4a97C-1l1lA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nba N-CARBAMOYLSARCOSINE
AMIDOHYDROLASE

(Arthrobacter
sp.) 		PF00857
(Isochorismatase) 		4 VAL A  75
MET A  68
ILE A  71
GLU A 139
 None
 0.90A 4a97C-1nbaA:
undetectable		 4a97C-1nbaA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nt2 FIBRILLARIN-LIKE
PRE-RRNA PROCESSING
PROTEIN

(Archaeoglobus
fulgidus) 		PF01269
(Fibrillarin) 		4 TYR A 208
VAL A 157
ILE A 130
GLU A 184
 None
 1.06A 4a97C-1nt2A:
0.0		 4a97C-1nt2A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o12 N-ACETYLGLUCOSAMINE-
6-PHOSPHATE
DEACETYLASE

(Thermotoga
maritima) 		PF01979
(Amidohydro_1) 		4 TYR A 319
VAL A 316
ILE A 250
ASN A 320
 None
 1.03A 4a97C-1o12A:
0.0		 4a97C-1o12A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qdl PROTEIN
(ANTHRANILATE
SYNTHASE
(TRPE-SUBUNIT))

(Sulfolobus
solfataricus) 		PF00425
(Chorismate_bind)
PF04715
(Anth_synt_I_N) 		4 TYR A  41
VAL A  43
ILE A 118
GLU A 371
 None
 1.07A 4a97C-1qdlA:
undetectable		 4a97C-1qdlA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tvm PTS SYSTEM,
GALACTITOL-SPECIFIC
IIB COMPONENT

(Escherichia
coli) 		PF02302
(PTS_IIB) 		4 PHE A  17
TYR A  16
ASN A  14
GLU A  54
 None
 0.98A 4a97C-1tvmA:
undetectable		 4a97C-1tvmA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1twd COPPER HOMEOSTASIS
PROTEIN CUTC

(Shigella
flexneri) 		PF03932
(CutC) 		4 VAL A 118
MET A 106
ILE A 109
GLU A   5
 None
 1.08A 4a97C-1twdA:
undetectable		 4a97C-1twdA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xew SMC PROTEIN

(Pyrococcus
furiosus) 		PF02463
(SMC_N) 		4 PHE X  12
TYR X  15
VAL X  82
ILE X  84
 None
 0.92A 4a97C-1xewX:
undetectable		 4a97C-1xewX:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xmx HYPOTHETICAL PROTEIN
VC1899

(Vibrio cholerae) 		PF09002
(DUF1887) 		4 PHE A 106
TYR A 109
VAL A  87
ILE A   3
 None
 1.02A 4a97C-1xmxA:
undetectable		 4a97C-1xmxA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yal CHYMOPAPAIN

(Carica papaya) 		PF00112
(Peptidase_C1) 		4 VAL A 161
MET A 191
ILE A 177
ASN A 179
 None
 0.85A 4a97C-1yalA:
undetectable		 4a97C-1yalA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2az3 NUCLEOSIDE
DIPHOSPHATE KINASE

(Halobacterium
salinarum) 		PF00334
(NDK) 		4 ARG A 106
ILE A 118
ASN A 116
GLU A  55
 CDP  A1100 ( 4.8A)
None
CDP  A1100 (-3.1A)
MG  A 201 ( 2.7A)
 1.08A 4a97C-2az3A:
undetectable		 4a97C-2az3A:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e18 NH(3)-DEPENDENT
NAD(+) SYNTHETASE

(Pyrococcus
horikoshii) 		PF02540
(NAD_synthase) 		4 TYR A 197
VAL A 161
ILE A 153
ASN A 131
 None
None
None
ZN  A1305 ( 4.9A)
 0.99A 4a97C-2e18A:
undetectable		 4a97C-2e18A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eaa 7S GLOBULIN-3

(Vigna angularis) 		PF00190
(Cupin_1) 		4 PHE A  47
TYR A  60
VAL A  62
ILE A 134
 None
 0.88A 4a97C-2eaaA:
undetectable		 4a97C-2eaaA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iuy GLYCOSYLTRANSFERASE

(Streptomyces
viridochromogenes) 		PF00534
(Glycos_transf_1) 		4 TYR A  39
VAL A 230
ILE A 227
GLU A 270
 None
MES  A1353 (-3.4A)
None
None
 1.05A 4a97C-2iuyA:
undetectable		 4a97C-2iuyA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2okx RHAMNOSIDASE B

(Bacillus sp.
GL1) 		PF05592
(Bac_rhamnosid)
PF08531
(Bac_rhamnosid_N)
PF17389
(Bac_rhamnosid6H)
PF17390
(Bac_rhamnosid_C) 		4 PHE A 806
ILE A 626
ASN A 628
GLU A 809
 None
 1.10A 4a97C-2okxA:
3.7		 4a97C-2okxA:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qjt NICOTINAMIDE-NUCLEOT
IDE
ADENYLYLTRANSFERASE

(Francisella
tularensis) 		no annotation 4 PHE B  51
ILE B  33
ASN B  94
GLU B  52
 None
 1.07A 4a97C-2qjtB:
undetectable		 4a97C-2qjtB:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qn0 NEUROTOXIN

(Clostridium
botulinum) 		PF01742
(Peptidase_M27) 		4 TYR A 202
VAL A 379
ILE A 256
GLU A 360
 None
 0.89A 4a97C-2qn0A:
undetectable		 4a97C-2qn0A:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qqp LARGE CAPSID PROTEIN

(Providence
virus) 		PF03566
(Peptidase_A21) 		4 PHE A 458
VAL A 405
ILE A 263
ASN A 406
 None
 1.08A 4a97C-2qqpA:
undetectable		 4a97C-2qqpA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r6f EXCINUCLEASE ABC
SUBUNIT A

(Geobacillus
stearothermophilus) 		PF00005
(ABC_tran) 		4 TYR A 315
VAL A 375
ILE A 376
ASN A 378
 None
 1.07A 4a97C-2r6fA:
undetectable		 4a97C-2r6fA:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uut RNA-DIRECTED RNA
POLYMERASE

(Sapporo virus) 		PF00680
(RdRP_1) 		4 PHE A 337
TYR A  90
VAL A  87
ILE A 261
 None
 1.10A 4a97C-2uutA:
undetectable		 4a97C-2uutA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yqu 2-OXOGLUTARATE
DEHYDROGENASE E3
COMPONENT

(Thermus
thermophilus) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 TYR A 265
VAL A 303
ILE A 284
GLU A  31
 FAD  A1601 (-4.8A)
None
None
FAD  A1601 (-2.7A)
 0.87A 4a97C-2yquA:
2.3		 4a97C-2yquA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z3k LEUCYL/PHENYLALANYL-
TRNA-PROTEIN
TRANSFERASE

(Escherichia
coli) 		PF03588
(Leu_Phe_trans) 		4 TYR A  87
VAL A  89
MET A 144
ILE A 132
 None
None
PHE  A 302 ( 3.6A)
None
 0.72A 4a97C-2z3kA:
undetectable		 4a97C-2z3kA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zi8 PROBABLE
BIPHENYL-2,3-DIOL
1,2-DIOXYGENASE BPHC

(Mycobacterium
tuberculosis) 		PF00903
(Glyoxalase) 		4 PHE A 136
VAL A 218
MET A 257
ILE A 265
 None
 0.96A 4a97C-2zi8A:
undetectable		 4a97C-2zi8A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3al8 SEMAPHORIN-6A

(Mus musculus) 		PF01403
(Sema)
PF01437
(PSI) 		4 PHE A 291
TYR A 292
ILE A 295
ASN A 294
 None
 1.09A 4a97C-3al8A:
undetectable		 4a97C-3al8A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dg8 BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE

(Plasmodium
falciparum) 		PF00186
(DHFR_1) 		4 VAL A 140
MET A 104
ILE A 126
ASN A 124
 None
RJ6  A 609 ( 4.0A)
None
None
 0.99A 4a97C-3dg8A:
undetectable		 4a97C-3dg8A:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3doo SHIKIMATE
DEHYDROGENASE

(Staphylococcus
epidermidis) 		PF01488
(Shikimate_DH)
PF08501
(Shikimate_dh_N) 		4 TYR A  97
VAL A  84
ILE A  67
GLU A  76
 None
 0.93A 4a97C-3dooA:
undetectable		 4a97C-3dooA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dwl ACTIN-RELATED
PROTEIN 2/3 COMPLEX
SUBUNIT 4

(Schizosaccharomyces
pombe) 		PF05856
(ARPC4) 		4 PHE F 138
VAL F 142
MET F 149
ILE F 146
 None
 1.10A 4a97C-3dwlF:
undetectable		 4a97C-3dwlF:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dzu PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep)
PF00105
(zf-C4) 		4 PHE D 368
VAL D 339
ILE D 341
GLU D 365
 None
None
PLB  D 701 (-3.6A)
None
 1.10A 4a97C-3dzuD:
0.9		 4a97C-3dzuD:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ejg NON-STRUCTURAL
PROTEIN 3

(Human
coronavirus
229E) 		PF01661
(Macro) 		4 PHE A   6
TYR A  15
VAL A 150
ILE A 120
 None
 0.99A 4a97C-3ejgA:
undetectable		 4a97C-3ejgA:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ele AMINO TRANSFERASE

([Eubacterium]
rectale) 		PF00155
(Aminotran_1_2) 		4 TYR A 219
ILE A 177
ASN A 178
GLU A 221
 PLP  A 500 (-4.4A)
None
PLP  A 500 (-3.0A)
EDO  A 501 ( 3.8A)
 0.94A 4a97C-3eleA:
undetectable		 4a97C-3eleA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3erv PUTATIVE C39-LIKE
PEPTIDASE

(Bacillus
anthracis) 		PF13529
(Peptidase_C39_2) 		4 TYR A 207
VAL A 212
ILE A 214
GLU A 155
 None
 1.11A 4a97C-3ervA:
undetectable		 4a97C-3ervA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ewr NON-STRUCTURAL
PROTEIN 3

(Human
coronavirus
229E) 		PF01661
(Macro) 		4 PHE A   7
TYR A  16
VAL A 151
ILE A 121
 None
None
APR  A 169 ( 4.6A)
None
 0.94A 4a97C-3ewrA:
undetectable		 4a97C-3ewrA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fmq METHIONINE
AMINOPEPTIDASE 2

(Encephalitozoon
cuniculi) 		PF00557
(Peptidase_M24) 		4 PHE A 148
VAL A 146
MET A 101
ILE A 129
 None
 1.07A 4a97C-3fmqA:
0.6		 4a97C-3fmqA:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gpg NON-STRUCTURAL
PROTEIN 3

(Chikungunya
virus) 		PF01661
(Macro) 		4 VAL A  19
ILE A  11
ASN A  14
GLU A  43
 None
 1.06A 4a97C-3gpgA:
undetectable		 4a97C-3gpgA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hur ALANINE RACEMASE

(Oenococcus oeni) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		4 VAL A 252
ARG A 371
ILE A 369
GLU A 343
 None
 1.11A 4a97C-3hurA:
undetectable		 4a97C-3hurA:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ib5 SEX PHEROMONE
PRECURSOR

(Lactobacillus
salivarius) 		PF07537
(CamS) 		4 TYR A 146
VAL A 147
MET A 227
ILE A 172
 None
 0.85A 4a97C-3ib5A:
undetectable		 4a97C-3ib5A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j82 C-TYPE LECTIN DOMAIN
FAMILY 9 MEMBER A

(Mus musculus) 		PF00059
(Lectin_C) 		4 TYR A 236
VAL A 198
MET A 181
ILE A 175
 None
 1.07A 4a97C-3j82A:
undetectable		 4a97C-3j82A:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jbh MYOSIN 2 HEAVY CHAIN
STRIATED MUSCLE

(Aphonopelma) 		PF00063
(Myosin_head)
PF01576
(Myosin_tail_1)
PF02736
(Myosin_N) 		4 PHE A 338
TYR A 342
VAL A 346
ILE A 349
 None
 0.99A 4a97C-3jbhA:
undetectable		 4a97C-3jbhA:
9.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ll9 ISOPENTENYL
PHOSPHATE KINASE

(Methanothermobacter
thermautotrophicus) 		PF00696
(AA_kinase) 		4 VAL A  10
ARG A  28
ILE A  29
ASN A  25
 None
 1.04A 4a97C-3ll9A:
1.2		 4a97C-3ll9A:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ml6 CHIMERIC COMPLEX
BETWEEN PROTEIN
DISHEVLLED2 HOMOLOG
DVL-2 AND CLATHRIN
ADAPTOR AP-2 COMPLEX
SUBUNIT MU

(Mus musculus;
Rattus
norvegicus) 		PF00610
(DEP)
PF00928
(Adap_comp_sub) 		4 PHE A 469
TYR A 463
VAL A 466
MET A 430
 None
 0.95A 4a97C-3ml6A:
undetectable		 4a97C-3ml6A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p8s JACALIN

(Artocarpus
heterophyllus) 		PF01419
(Jacalin) 		4 PHE A 128
TYR A  95
VAL A 105
ILE A  49
 None
 1.08A 4a97C-3p8sA:
undetectable		 4a97C-3p8sA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pco PHENYLALANYL-TRNA
SYNTHETASE, BETA
CHAIN

(Escherichia
coli) 		PF01588
(tRNA_bind)
PF03147
(FDX-ACB)
PF03483
(B3_4)
PF03484
(B5) 		4 VAL B 250
ILE B 246
ASN B 254
GLU B 334
 None
 1.07A 4a97C-3pcoB:
undetectable		 4a97C-3pcoB:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pg7 NEUROFIBROMIN

(Homo sapiens) 		PF13716
(CRAL_TRIO_2) 		4 PHE A1719
VAL A1736
ILE A1805
GLU A1794
 None
 1.01A 4a97C-3pg7A:
undetectable		 4a97C-3pg7A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3um6 BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE

(Plasmodium
falciparum) 		PF00186
(DHFR_1)
PF00303
(Thymidylat_synt) 		4 VAL A 140
MET A 104
ILE A 126
ASN A 124
 None
1CY  A 609 ( 4.5A)
None
None
 0.83A 4a97C-3um6A:
undetectable		 4a97C-3um6A:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v9e LACCASE

(Botrytis aclada) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 PHE A 393
TYR A 397
VAL A 399
GLU A 390
 None
 1.10A 4a97C-3v9eA:
undetectable		 4a97C-3v9eA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vtz GLUCOSE
1-DEHYDROGENASE

(Thermoplasma
volcanium) 		PF13561
(adh_short_C2) 		4 TYR A 109
VAL A 105
ILE A 101
ASN A 106
 None
 0.86A 4a97C-3vtzA:
undetectable		 4a97C-3vtzA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vys HYDROGENASE
EXPRESSION/FORMATION
PROTEIN HYPD

(Thermococcus
kodakarensis) 		PF01924
(HypD) 		4 VAL B  58
ILE B  32
ASN B  57
GLU B  19
 None
 0.98A 4a97C-3vysB:
undetectable		 4a97C-3vysB:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wcy INTERFERON
ALPHA/BETA RECEPTOR
1

(Mus musculus) 		PF01108
(Tissue_fac)
PF09294
(Interfer-bind) 		4 TYR A 370
VAL A 372
MET A 352
ILE A 339
 None
 0.88A 4a97C-3wcyA:
undetectable		 4a97C-3wcyA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wiq KOJIBIOSE
PHOSPHORYLASE

(Caldicellulosiruptor
saccharolyticus) 		PF03632
(Glyco_hydro_65m)
PF03633
(Glyco_hydro_65C)
PF03636
(Glyco_hydro_65N) 		4 PHE A 655
VAL A 307
ILE A 311
ASN A 310
 None
 0.93A 4a97C-3wiqA:
3.0		 4a97C-3wiqA:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wr7 SPERMIDINE
N1-ACETYLTRANSFERASE

(Escherichia
coli) 		PF13302
(Acetyltransf_3) 		4 TYR A  30
VAL A 122
ILE A 130
ASN A 126
 COA  A 202 (-3.4A)
COA  A 202 ( 4.8A)
None
COA  A 202 ( 4.7A)
 1.05A 4a97C-3wr7A:
undetectable		 4a97C-3wr7A:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bih UNCHARACTERIZED
LIPOPROTEIN
SAOUHSC_00053

(Staphylococcus
aureus) 		PF04507
(DUF576) 		4 TYR A 125
VAL A 127
ILE A 134
GLU A 122
 None
 1.06A 4a97C-4bihA:
undetectable		 4a97C-4bihA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c1n IRON-SULFUR CLUSTER
BINDING PROTEIN

(Carboxydothermus
hydrogenoformans) 		PF14574
(DUF4445) 		4 VAL I 538
MET I 384
ILE I 376
GLU I 533
 None
 1.06A 4a97C-4c1nI:
undetectable		 4a97C-4c1nI:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c8q DNA TOPOISOMERASE
2-ASSOCIATED PROTEIN
PAT1

(Saccharomyces
cerevisiae) 		PF09770
(PAT1) 		4 PHE H 681
VAL H 727
ILE H 724
GLU H 701
 None
None
None
CO  H1080 (-3.8A)
 1.08A 4a97C-4c8qH:
1.5		 4a97C-4c8qH:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4crn ERF1 IN
RIBOSOME-BOUND
ERF1-ERF3-GDPNP
COMPLEX

(Saccharomyces
cerevisiae) 		PF03463
(eRF1_1)
PF03464
(eRF1_2)
PF03465
(eRF1_3) 		4 TYR X 277
VAL X   5
ILE X 387
ASN X   8
 None
 1.09A 4a97C-4crnX:
undetectable		 4a97C-4crnX:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eg9 UNCHARACTERIZED
PROTEIN
SAOUHSC_02783

(Staphylococcus
aureus) 		PF04507
(DUF576) 		4 VAL A  95
ILE A  75
ASN A  77
GLU A 126
 None
 0.74A 4a97C-4eg9A:
undetectable		 4a97C-4eg9A:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f92 U5 SMALL NUCLEAR
RIBONUCLEOPROTEIN
200 KDA HELICASE

(Homo sapiens) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF02889
(Sec63) 		4 VAL B1099
MET B1092
ILE B1095
GLU B1226
 None
 1.07A 4a97C-4f92B:
undetectable		 4a97C-4f92B:
10.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fyc THIOL:DISULFIDE
INTERCHANGE PROTEIN
(DSBC)

(Helicobacter
pylori) 		PF13098
(Thioredoxin_2) 		4 PHE A  67
TYR A 116
VAL A  83
ILE A 158
 None
 0.99A 4a97C-4fycA:
undetectable		 4a97C-4fycA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iug BETA-GALACTOSIDASE A

(Aspergillus
oryzae) 		PF01301
(Glyco_hydro_35)
PF10435
(BetaGal_dom2)
PF13363
(BetaGal_dom3)
PF13364
(BetaGal_dom4_5) 		4 TYR A 957
VAL A 925
ILE A 949
ASN A 926
 None
 1.10A 4a97C-4iugA:
undetectable		 4a97C-4iugA:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k91 D-ALA-D-ALA-CARBOXYP
EPTIDASE

(Pseudomonas
aeruginosa) 		PF00768
(Peptidase_S11)
PF07943
(PBP5_C) 		4 PHE A 230
VAL A 228
MET A  20
ILE A 226
 None
 1.06A 4a97C-4k91A:
undetectable		 4a97C-4k91A:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p27 VENOM ALLERGEN-LIKE
(VAL) 4 PROTEIN

(Schistosoma
mansoni) 		PF00188
(CAP) 		4 PHE A  14
VAL A  18
ILE A  27
GLU A  85
 None
 1.06A 4a97C-4p27A:
undetectable		 4a97C-4p27A:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p68 DIHYDROFOLATE
REDUCTASE

(Escherichia
coli) 		PF00186
(DHFR_1) 		4 VAL A  72
MET A  42
ILE A  61
ASN A  59
 None
None
None
XCN  A  54 ( 3.0A)
 0.84A 4a97C-4p68A:
undetectable		 4a97C-4p68A:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pvc NADPH-DEPENDENT
METHYLGLYOXAL
REDUCTASE GRE2

(Saccharomyces
cerevisiae) 		PF01073
(3Beta_HSD) 		4 VAL A 101
ILE A  98
ASN A 102
GLU A 182
 None
 1.07A 4a97C-4pvcA:
undetectable		 4a97C-4pvcA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q8k ALGINASE

(Pseudoalteromonas
sp. SM0524) 		PF08787
(Alginate_lyase2) 		4 PHE A 239
TYR A 395
VAL A 393
ILE A 175
 None
 1.01A 4a97C-4q8kA:
undetectable		 4a97C-4q8kA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q8l ALGINASE

(Pseudoalteromonas
sp. SM0524) 		PF08787
(Alginate_lyase2) 		4 PHE A  72
TYR A 228
VAL A 226
ILE A   8
 None
 0.99A 4a97C-4q8lA:
undetectable		 4a97C-4q8lA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qni UNCHARACTERIZED
PROTEIN

(Bacteroides
thetaiotaomicron) 		PF14274
(DUF4361)
PF16343
(DUF4973) 		4 TYR A 328
VAL A 330
ILE A 200
ASN A 202
 None
None
EDO  A 403 ( 4.1A)
EDO  A 403 ( 4.9A)
 1.00A 4a97C-4qniA:
undetectable		 4a97C-4qniA:
20.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4twf CYS-LOOP
LIGAND-GATED ION
CHANNEL

(Dickeya
chrysanthemi) 		PF02931
(Neur_chan_LBD) 		6 PHE A  19
TYR A  38
VAL A  40
ARG A  91
MET A  93
ILE A 101
 None
 0.55A 4a97C-4twfA:
33.8		 4a97C-4twfA:
99.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4twf CYS-LOOP
LIGAND-GATED ION
CHANNEL

(Dickeya
chrysanthemi) 		PF02931
(Neur_chan_LBD) 		5 PHE A  19
VAL A  40
ARG A  91
MET A  93
ASN A 103
 None
 0.90A 4a97C-4twfA:
33.8		 4a97C-4twfA:
99.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4unw H3 HAEMAGGLUTININ
HA1 CHAIN

(Influenza A
virus) 		PF00509
(Hemagglutinin) 		4 TYR A  56
VAL A  58
MET A 268
ILE A  88
 None
 0.95A 4a97C-4unwA:
undetectable		 4a97C-4unwA:
22.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4yeu CYS-LOOP
LIGAND-GATED ION
CHANNEL,PROTON-GATED
ION CHANNEL

(Dickeya
chrysanthemi;
Gloeobacter
violaceus) 		PF02931
(Neur_chan_LBD) 		7 PHE A  19
TYR A  38
VAL A  40
ARG A  91
MET A  93
ILE A 101
ASN A 103
 None
 0.64A 4a97C-4yeuA:
29.4		 4a97C-4yeuA:
71.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cmn LATROPHILIN-3

(Homo sapiens) 		PF02191
(OLF) 		4 PHE E 314
VAL E 367
ILE E 364
ASN E 312
 None
CA  E 401 (-4.8A)
None
CA  E 401 (-3.3A)
 1.01A 4a97C-5cmnE:
undetectable		 4a97C-5cmnE:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5czz CRISPR-ASSOCIATED
ENDONUCLEASE CAS9

(Staphylococcus
aureus) 		PF13395
(HNH_4)
PF16592
(Cas9_REC) 		4 ARG A 980
ILE A 982
ASN A 995
GLU A1006
 None
 1.05A 4a97C-5czzA:
undetectable		 4a97C-5czzA:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dxv RETHREADED DHFR

(synthetic
construct) 		PF00186
(DHFR_1) 		4 VAL A  89
MET A  59
ILE A  78
ASN A  76
 None
 0.79A 4a97C-5dxvA:
undetectable		 4a97C-5dxvA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e9o CELLULASE, GLYCOSYL
HYDROLASE FAMILY 5,
TPS LINKER, DOMAIN X

(Spirochaeta
thermophila) 		no annotation 4 TYR A 526
ILE A 517
ASN A 503
GLU A 461
 None
 0.90A 4a97C-5e9oA:
undetectable		 4a97C-5e9oA:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5flz SPINDLE POLE BODY
COMPONENT SPC98

(Saccharomyces
cerevisiae) 		PF04130
(Spc97_Spc98) 		4 TYR B 187
VAL B 188
ILE B 224
GLU B 182
 None
 1.05A 4a97C-5flzB:
undetectable		 4a97C-5flzB:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fno MANGANESE
LIPOXYGENASE

(Magnaporthe
oryzae) 		PF00305
(Lipoxygenase) 		4 VAL A 573
MET A 566
ILE A 569
GLU A 476
 None
 1.06A 4a97C-5fnoA:
undetectable		 4a97C-5fnoA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ftt ADHESION G
PROTEIN-COUPLED
RECEPTOR L3

(Mus musculus) 		PF02140
(Gal_Lectin)
PF02191
(OLF) 		4 PHE C 382
VAL C 435
ILE C 432
ASN C 380
 None
CA  C1467 (-4.8A)
None
CA  C1467 (-3.7A)
 1.03A 4a97C-5fttC:
undetectable		 4a97C-5fttC:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ii5 MALTOSE-BINDING
PERIPLASMIC
PROTEIN,VITELLINE
ENVELOPE SPERM LYSIN
RECEPTOR

(Escherichia
coli;
Haliotis
rufescens) 		PF11386
(VERL)
PF13416
(SBP_bac_8) 		4 PHE A4106
VAL A4123
MET A4077
ILE A4070
 None
 0.79A 4a97C-5ii5A:
undetectable		 4a97C-5ii5A:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l0l UNCHARACTERIZED
PROTEIN

(Legionella
pneumophila) 		no annotation 4 TYR A 130
VAL A 132
MET A 224
ILE A 144
 None
 0.70A 4a97C-5l0lA:
undetectable		 4a97C-5l0lA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lmg DNA TOPOISOMERASE
2-ASSOCIATED PROTEIN
PAT1

(Saccharomyces
cerevisiae) 		PF09770
(PAT1) 		4 PHE A 681
VAL A 727
ILE A 724
GLU A 701
 None
None
None
EDO  A 804 (-2.9A)
 1.10A 4a97C-5lmgA:
undetectable		 4a97C-5lmgA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mpd 26S PROTEASOME
REGULATORY SUBUNIT
RPN6

(Saccharomyces
cerevisiae) 		PF01399
(PCI) 		4 VAL Q 302
MET Q 271
ILE Q 270
GLU Q 322
 None
 0.86A 4a97C-5mpdQ:
4.3		 4a97C-5mpdQ:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n0l GTP-SENSING
TRANSCRIPTIONAL
PLEIOTROPIC
REPRESSOR CODY

(Clostridioides
difficile) 		no annotation 4 PHE A  74
TYR A  78
VAL A  82
ILE A  85
 ILE  A 201 ( 4.7A)
None
None
None
 1.01A 4a97C-5n0lA:
undetectable		 4a97C-5n0lA:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ofb MORC FAMILY CW-TYPE
ZINC FINGER PROTEIN
2

(Homo sapiens) 		no annotation 4 TYR B 418
VAL B 416
ILE B 384
ASN B 386
 None
 1.10A 4a97C-5ofbB:
undetectable		 4a97C-5ofbB:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5te1 ATP-CITRATE SYNTHASE

(Homo sapiens) 		PF00549
(Ligase_CoA)
PF02629
(CoA_binding)
PF16114
(Citrate_bind) 		4 PHE A 493
VAL A 568
ILE A 591
GLU A 683
 None
 1.02A 4a97C-5te1A:
undetectable		 4a97C-5te1A:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tet ATP-CITRATE SYNTHASE

(Homo sapiens) 		PF00549
(Ligase_CoA)
PF02629
(CoA_binding) 		4 PHE B 493
VAL B 568
ILE B 591
GLU B 683
 None
 0.99A 4a97C-5tetB:
undetectable		 4a97C-5tetB:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5trv DENOVO NTF2

(synthetic
construct) 		PF12680
(SnoaL_2) 		4 PHE A  41
VAL A  36
MET A  88
ILE A 106
 PEG  A 201 (-4.3A)
None
None
None
 0.94A 4a97C-5trvA:
undetectable		 4a97C-5trvA:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u7x NOD FACTOR BINDING
LECTIN-NUCLEOTIDE
PHOSPHOHYDROLASE

(Vigna
unguiculata) 		PF01150
(GDA1_CD39) 		4 TYR F 209
VAL F 164
ILE F 157
GLU F 185
 None
 1.10A 4a97C-5u7xF:
undetectable		 4a97C-5u7xF:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5udy ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 7

(Homo sapiens) 		PF01663
(Phosphodiest) 		4 TYR A 194
VAL A  36
ILE A 243
GLU A 171
 None
None
None
FUC  A 508 ( 4.3A)
 0.93A 4a97C-5udyA:
undetectable		 4a97C-5udyA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uwb TOLUENE TOLERANCE
PROTEIN

(Pseudomonas
putida) 		no annotation 4 TYR B 144
VAL B 164
ILE B 167
ASN B 165
 PEF  B 302 (-4.0A)
PEF  B 302 ( 4.6A)
None
PEF  B 302 ( 4.1A)
 0.94A 4a97C-5uwbB:
undetectable		 4a97C-5uwbB:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vf3 MAJOR CAPSID PROTEIN

(Escherichia
virus T4) 		PF07068
(Gp23) 		4 PHE A 434
VAL A 382
ILE A 521
GLU A 360
 None
 1.08A 4a97C-5vf3A:
undetectable		 4a97C-5vf3A:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xns CHROMOSOME PARTITION
PROTEIN SMC

(Pyrococcus
furiosus) 		PF02463
(SMC_N) 		4 PHE A  12
TYR A  15
VAL A  82
ILE A  84
 None
 0.98A 4a97C-5xnsA:
undetectable		 4a97C-5xnsA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yfb DIPEPTIDYL PEPTIDASE
3

(Armillaria
tabescens) 		no annotation 4 TYR A 313
VAL A 314
ILE A 164
GLU A 324
 None
 1.04A 4a97C-5yfbA:
undetectable		 4a97C-5yfbA:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6azt ASPARAGINYL
ENDOPEPTIDASE 1

(Helianthus
annuus) 		no annotation 4 PHE A 100
VAL A  63
MET A 213
ILE A 171
 None
 0.90A 4a97C-6aztA:
undetectable		 4a97C-6aztA:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6caa ELECTROGENIC SODIUM
BICARBONATE
COTRANSPORTER 1

(Homo sapiens) 		no annotation 4 PHE A 865
TYR A 862
VAL A 864
ILE A 692
 None
 1.04A 4a97C-6caaA:
undetectable		 4a97C-6caaA:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d46 BETA SLIDING CLAMP

(Rickettsia
typhi) 		no annotation 4 PHE A 353
TYR A 352
VAL A 362
ILE A 376
 None
 0.96A 4a97C-6d46A:
undetectable		 4a97C-6d46A:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f36 MITOCHONDRIAL ATP
SYNTHASE SUBUNIT
ASA6

(Polytomella sp.
Pringsheim
198.80) 		no annotation 4 PHE N 129
TYR N 126
VAL N 125
ILE N 120
 None
 1.11A 4a97C-6f36N:
undetectable		 4a97C-6f36N:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bg4 ENDO-1,4-BETA-XYLANA
SE

(Penicillium
simplicissimum) 		PF00331
(Glyco_hydro_10) 		4 GLU A  56
PHE A  62
HIS A  84
VAL A  71
 None
None
GOL  A 629 ( 3.8A)
None
 1.04A 4a97D-1bg4A:
undetectable		 4a97D-1bg4A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e1c METHYLMALONYL-COA
MUTASE ALPHA CHAIN

(Propionibacterium
freudenreichii) 		PF01642
(MM_CoA_mutase)
PF02310
(B12-binding) 		4 GLU A 447
ILE A 566
GLU A 448
VAL A 427
 None
 1.02A 4a97D-1e1cA:
undetectable		 4a97D-1e1cA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e4o MALTODEXTRIN
PHOSPHORYLASE

(Escherichia
coli) 		PF00343
(Phosphorylase) 		4 ILE A 627
GLU A 629
TYR A 747
VAL A 706
 None
 1.10A 4a97D-1e4oA:
2.7		 4a97D-1e4oA:
16.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ikp EXOTOXIN A

(Pseudomonas
aeruginosa) 		PF09009
(Exotox-A_cataly)
PF09101
(Exotox-A_bind)
PF09102
(Exotox-A_target) 		4 GLU A 591
ILE A 594
TYR A 502
VAL A 455
 None
 1.06A 4a97D-1ikpA:
0.1		 4a97D-1ikpA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ixk METHYLTRANSFERASE

(Pyrococcus
horikoshii) 		PF01189
(Methyltr_RsmB-F)
PF17125
(Methyltr_RsmF_N) 		4 GLU A 252
ILE A 218
GLU A 253
PHE A 256
 None
 0.97A 4a97D-1ixkA:
undetectable		 4a97D-1ixkA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l8t AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E

(Enterococcus
faecalis) 		PF01636
(APH) 		4 ILE A 112
PHE A 242
HIS A 188
VAL A 185
 None
 0.83A 4a97D-1l8tA:
0.6		 4a97D-1l8tA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qfc PROTEIN (PURPLE ACID
PHOSPHATASE)

(Rattus
norvegicus) 		PF00149
(Metallophos) 		4 GLU A  69
PHE A  23
TYR A 104
VAL A  98
 None
 0.95A 4a97D-1qfcA:
undetectable		 4a97D-1qfcA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sus CAFFEOYL-COA
O-METHYLTRANSFERASE

(Medicago sativa) 		PF01596
(Methyltransf_3) 		4 GLU A  85
ILE A 107
HIS A  43
VAL A  38
 SAH  A 301 (-4.1A)
None
None
None
 1.06A 4a97D-1susA:
undetectable		 4a97D-1susA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x1q TRYPTOPHAN SYNTHASE
BETA CHAIN

(Thermus
thermophilus) 		PF00291
(PALP) 		4 GLU A 336
ILE A 260
PHE A  30
VAL A  38
 None
CL  A1001 (-4.0A)
None
None
 1.09A 4a97D-1x1qA:
undetectable		 4a97D-1x1qA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xr0 FGFR SIGNALLING
ADAPTOR SNT-1

(Homo sapiens) 		PF02174
(IRS) 		4 GLU B  44
ILE B  46
GLU B  39
VAL B  13
 None
 1.08A 4a97D-1xr0B:
undetectable		 4a97D-1xr0B:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ygu LEUKOCYTE COMMON
ANTIGEN

(Homo sapiens) 		PF00102
(Y_phosphatase) 		4 GLU A 894
GLU A1167
TYR A 767
VAL A 722
 None
 0.87A 4a97D-1yguA:
undetectable		 4a97D-1yguA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zhn CD1D1 ANTIGEN

(Mus musculus) 		PF07654
(C1-set)
PF16497
(MHC_I_3) 		4 GLU A 105
GLU A 113
PHE A 115
VAL A 136
 None
 1.10A 4a97D-1zhnA:
2.3		 4a97D-1zhnA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zwx SPHINGOMYELINASE-C

(Listeria
ivanovii) 		PF03372
(Exo_endo_phos) 		4 ILE A 218
TYR A 169
HIS A 151
VAL A 137
 None
 1.07A 4a97D-1zwxA:
undetectable		 4a97D-1zwxA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2czr TBP-INTERACTING
PROTEIN

(Thermococcus
kodakarensis) 		PF15517
(TBPIP_N) 		4 GLU A 151
ILE A 170
TYR A 147
HIS A 179
 None
 1.07A 4a97D-2czrA:
undetectable		 4a97D-2czrA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2di4 CELL DIVISION
PROTEIN FTSH HOMOLOG

(Aquifex
aeolicus) 		PF01434
(Peptidase_M41) 		4 GLU A 480
ILE A 489
GLU A 481
TYR A 559
 None
 1.03A 4a97D-2di4A:
undetectable		 4a97D-2di4A:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dph FORMALDEHYDE
DISMUTASE

(Pseudomonas
putida) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 ILE A 170
GLU A  67
PHE A  92
VAL A  58
 None
ZN  A1002 ( 4.6A)
NAD  A1403 (-4.2A)
None
 1.06A 4a97D-2dphA:
undetectable		 4a97D-2dphA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e3z BETA-GLUCOSIDASE

(Phanerochaete
chrysosporium) 		PF00232
(Glyco_hydro_1) 		4 GLU A  22
ILE A  21
TYR A  76
VAL A 111
 None
 1.07A 4a97D-2e3zA:
undetectable		 4a97D-2e3zA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2esf CARBONIC ANHYDRASE 2

(Escherichia
coli) 		PF00484
(Pro_CA) 		4 GLU A 148
TYR A  99
HIS A 184
VAL A  47
 None
 1.07A 4a97D-2esfA:
undetectable		 4a97D-2esfA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h1n OLIGOENDOPEPTIDASE F

(Geobacillus
stearothermophilus) 		PF01432
(Peptidase_M3) 		4 ILE A 372
GLU A 374
PHE A 113
TYR A  91
 None
 0.97A 4a97D-2h1nA:
1.9		 4a97D-2h1nA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h8r HEPATOCYTE NUCLEAR
FACTOR 1-BETA

(Homo sapiens) 		PF00046
(Homeobox)
PF04814
(HNF-1_N) 		4 GLU A 138
GLU A 178
HIS A 284
VAL A 278
 None
 0.94A 4a97D-2h8rA:
undetectable		 4a97D-2h8rA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hiv THERMOSTABLE DNA
LIGASE

(Sulfolobus
solfataricus) 		PF01068
(DNA_ligase_A_M)
PF04675
(DNA_ligase_A_N)
PF04679
(DNA_ligase_A_C) 		4 GLU A 406
TYR A 259
HIS A 387
VAL A 413
 None
 0.96A 4a97D-2hivA:
undetectable		 4a97D-2hivA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lm3 TRIPARTITE
MOTIF-CONTAINING
PROTEIN 5

(Macaca mulatta) 		PF00622
(SPRY) 		4 GLU A 395
GLU A 392
TYR A 480
VAL A 453
 None
 1.03A 4a97D-2lm3A:
undetectable		 4a97D-2lm3A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o04 PECTATE LYASE

(Bacillus
subtilis) 		PF00544
(Pec_lyase_C) 		4 ILE A 196
TYR A 242
HIS A 243
VAL A 277
 None
 1.07A 4a97D-2o04A:
undetectable		 4a97D-2o04A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qvw GLP_546_48378_50642

(Giardia
intestinalis) 		PF00636
(Ribonuclease_3)
PF02170
(PAZ) 		4 ILE A 346
GLU A 424
PHE A 414
HIS A 568
 None
 0.86A 4a97D-2qvwA:
undetectable		 4a97D-2qvwA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rhq PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN

(Staphylococcus
haemolyticus) 		PF01409
(tRNA-synt_2d) 		4 GLU A 118
GLU A 347
TYR A 324
VAL A 277
 None
 1.04A 4a97D-2rhqA:
undetectable		 4a97D-2rhqA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uxo HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR

(Pseudomonas
putida) 		PF00440
(TetR_N)
PF08361
(TetR_C_2) 		4 ILE A 109
GLU A  21
PHE A  24
VAL A  43
 None
 0.91A 4a97D-2uxoA:
undetectable		 4a97D-2uxoA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vmf BETA-MANNOSIDASE

(Bacteroides
thetaiotaomicron) 		PF00703
(Glyco_hydro_2) 		4 GLU A  90
PHE A 156
TYR A 153
HIS A 151
 EDO  A1875 (-3.3A)
None
None
None
 1.03A 4a97D-2vmfA:
undetectable		 4a97D-2vmfA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x2i ALPHA-1,4-GLUCAN
LYASE ISOZYME 1

(Gracilariopsis
lemaneiformis) 		PF01055
(Glyco_hydro_31) 		4 ILE A 147
TYR A  89
HIS A 325
VAL A 337
 None
None
None
CSO  A 336 ( 3.4A)
 1.08A 4a97D-2x2iA:
undetectable		 4a97D-2x2iA:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xss CGMP-SPECIFIC 3',
5'-CYCLIC
PHOSPHODIESTERASE

(Homo sapiens) 		PF01590
(GAF) 		4 GLU A 390
GLU A 392
TYR A 409
VAL A 415
 None
 1.04A 4a97D-2xssA:
undetectable		 4a97D-2xssA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z23 PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN

(Yersinia pestis) 		PF00496
(SBP_bac_5) 		4 GLU A 422
TYR A 420
HIS A 161
VAL A  48
 None
 1.10A 4a97D-2z23A:
undetectable		 4a97D-2z23A:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3adf MONOMERIC AZAMI
GREEN

(Galaxea
fascicularis) 		PF01353
(GFP) 		4 GLU A 144
TYR A 177
HIS A  88
VAL A 183
 None
 0.94A 4a97D-3adfA:
undetectable		 4a97D-3adfA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ahm OLIGOPEPTIDASE

(Geobacillus sp.
MO-1) 		no annotation 4 ILE A 372
GLU A 374
PHE A 113
TYR A  91
 None
 0.97A 4a97D-3ahmA:
2.3		 4a97D-3ahmA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d6b GLUTARYL-COA
DEHYDROGENASE

(Burkholderia
pseudomallei) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 GLU A  57
TYR A  32
HIS A  30
VAL A  25
 None
 1.07A 4a97D-3d6bA:
3.6		 4a97D-3d6bA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d6e BETA-GLUCANASE

(Bacillus
licheniformis) 		PF00722
(Glyco_hydro_16) 		4 GLU A  33
PHE A  10
TYR A 131
HIS A 132
 None
 1.06A 4a97D-3d6eA:
undetectable		 4a97D-3d6eA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dec BETA-GALACTOSIDASE

(Bacteroides
thetaiotaomicron) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF02929
(Bgal_small_N)
PF16353
(DUF4981) 		4 GLU A 335
TYR A 238
HIS A 237
VAL A 297
 None
 0.95A 4a97D-3decA:
1.6		 4a97D-3decA:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fa3 2,3-DIMETHYLMALATE
LYASE

(Aspergillus
niger) 		PF13714
(PEP_mutase) 		4 GLU A 191
GLU A 116
PHE A 189
VAL A 110
 OAF  A 501 (-2.8A)
None
None
None
 1.08A 4a97D-3fa3A:
undetectable		 4a97D-3fa3A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i12 D-ALANINE-D-ALANINE
LIGASE A

(Salmonella
enterica) 		PF01820
(Dala_Dala_lig_N)
PF07478
(Dala_Dala_lig_C) 		4 GLU A 230
ILE A 247
GLU A 228
VAL A 219
 None
None
ADP  A 365 (-2.9A)
None
 0.71A 4a97D-3i12A:
undetectable		 4a97D-3i12A:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jty BENF-LIKE PORIN

(Pseudomonas
protegens) 		PF03573
(OprD) 		4 GLU A 408
GLU A 373
PHE A 406
VAL A 359
 None
 1.08A 4a97D-3jtyA:
undetectable		 4a97D-3jtyA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k55 BETA-HEMOLYSIN

(Staphylococcus
aureus) 		PF03372
(Exo_endo_phos) 		4 ILE A 183
TYR A 134
HIS A 116
VAL A 102
 None
 1.08A 4a97D-3k55A:
undetectable		 4a97D-3k55A:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o5s BETA-GLUCANASE

(Bacillus
subtilis) 		PF00722
(Glyco_hydro_16) 		4 GLU A  74
PHE A  38
TYR A 172
HIS A 173
 None
 1.05A 4a97D-3o5sA:
undetectable		 4a97D-3o5sA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ohw PHYCOBILISOME LCM
CORE-MEMBRANE LINKER
POLYPEPTIDE

(Synechocystis
sp. PCC 6803) 		no annotation 4 GLU B 764
ILE B 756
HIS B 807
VAL B 839
 None
 1.11A 4a97D-3ohwB:
undetectable		 4a97D-3ohwB:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3olz GLUTAMATE RECEPTOR,
IONOTROPIC KAINATE 3

(Rattus
norvegicus) 		PF01094
(ANF_receptor) 		4 ILE A  52
GLU A  26
TYR A  13
HIS A  56
 None
 1.07A 4a97D-3olzA:
undetectable		 4a97D-3olzA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p2y ALANINE
DEHYDROGENASE/PYRIDI
NE NUCLEOTIDE
TRANSHYDROGENASE

(Mycolicibacterium
smegmatis) 		PF01262
(AlaDh_PNT_C)
PF05222
(AlaDh_PNT_N) 		4 GLU A  14
PHE A  90
HIS A 317
VAL A  23
 None
 0.99A 4a97D-3p2yA:
undetectable		 4a97D-3p2yA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pay PUTATIVE ADHESIN

(Bacteroides
ovatus) 		PF08842
(Mfa2) 		4 ILE A 217
GLU A 201
HIS A 144
VAL A 100
 None
 1.09A 4a97D-3payA:
undetectable		 4a97D-3payA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pvt PHENYLACETIC ACID
DEGRADATION PROTEIN
PAAA

(Escherichia
coli) 		PF05138
(PaaA_PaaC) 		4 GLU A 263
PHE A 264
TYR A 110
VAL A  44
 None
3HC  A 310 (-4.8A)
None
None
 1.07A 4a97D-3pvtA:
undetectable		 4a97D-3pvtA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s51 FANCONI ANEMIA GROUP
I PROTEIN HOMOLOG

(Mus musculus) 		PF14674
(FANCI_S1-cap)
PF14675
(FANCI_S1)
PF14676
(FANCI_S2)
PF14677
(FANCI_S3)
PF14678
(FANCI_S4)
PF14679
(FANCI_HD1)
PF14680
(FANCI_HD2) 		4 GLU A 247
TYR A 265
HIS A 266
VAL A 271
 None
 1.10A 4a97D-3s51A:
4.9		 4a97D-3s51A:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sk7 PROTEIN SEQA

(Vibrio cholerae) 		PF03925
(SeqA) 		4 GLU A  77
PHE A  78
HIS A  96
VAL A 143
 None
 1.07A 4a97D-3sk7A:
undetectable		 4a97D-3sk7A:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sks PUTATIVE
OLIGOENDOPEPTIDASE F

(Bacillus
anthracis) 		no annotation 4 ILE A 372
GLU A 374
PHE A 113
TYR A  91
 None
 0.86A 4a97D-3sksA:
2.5		 4a97D-3sksA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uv9 TRIPARTITE
MOTIF-CONTAINING
PROTEIN 5

(Macaca mulatta) 		PF00622
(SPRY) 		4 GLU A 395
GLU A 392
TYR A 480
VAL A 453
 None
 1.04A 4a97D-3uv9A:
undetectable		 4a97D-3uv9A:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3va7 KLLA0E08119P

(Kluyveromyces
lactis) 		PF00289
(Biotin_carb_N)
PF00364
(Biotin_lipoyl)
PF02626
(CT_A_B)
PF02682
(CT_C_D)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 ILE A1508
GLU A1505
TYR A1445
VAL A1323
 None
 1.06A 4a97D-3va7A:
undetectable		 4a97D-3va7A:
12.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vrd FLAVOCYTOCHROME C
FLAVIN SUBUNIT

(Thermochromatium
tepidum) 		PF07992
(Pyr_redox_2)
PF09242
(FCSD-flav_bind) 		4 GLU B 167
ILE B 340
GLU B  47
VAL B  60
 None
 0.88A 4a97D-3vrdB:
undetectable		 4a97D-3vrdB:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zvu ABSCISIC ACID
RECEPTOR PYR1

(Arabidopsis
thaliana) 		PF10604
(Polyketide_cyc2) 		4 GLU A  94
ILE A 110
HIS A  34
VAL A 139
 None
A8S  A 192 (-4.6A)
None
None
 0.93A 4a97D-3zvuA:
undetectable		 4a97D-3zvuA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a2n ISOPRENYLCYSTEINE
CARBOXYL
METHYLTRANSFERASE

(Methanosarcina
acetivorans) 		PF04140
(ICMT) 		4 GLU B  42
GLU B 167
TYR B 129
HIS B 131
 None
SAH  B1193 (-3.5A)
SAH  B1193 (-3.4A)
None
 1.05A 4a97D-4a2nB:
2.6		 4a97D-4a2nB:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4btf MIXED LINEAGE KINASE
DOMAIN-LIKE PROTEIN

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		4 GLU A 338
ILE A 254
PHE A 337
VAL A 388
 None
 1.06A 4a97D-4btfA:
3.9		 4a97D-4btfA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c1o BETA-XYLOSIDASE

(Parageobacillus
thermoglucosidasius) 		PF03512
(Glyco_hydro_52) 		4 GLU A 376
TYR A 338
HIS A  33
VAL A 124
 None
 1.06A 4a97D-4c1oA:
3.0		 4a97D-4c1oA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eyu LYSINE-SPECIFIC
DEMETHYLASE 6B

(Mus musculus) 		PF02373
(JmjC) 		4 GLU A1625
GLU A1626
TYR A1563
VAL A1618
 None
 1.09A 4a97D-4eyuA:
2.2		 4a97D-4eyuA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f4c MULTIDRUG RESISTANCE
PROTEIN PGP-1

(Caenorhabditis
elegans) 		PF00005
(ABC_tran)
PF00664
(ABC_membrane) 		4 ILE A 106
PHE A 778
HIS A 234
VAL A 362
 None
 1.01A 4a97D-4f4cA:
undetectable		 4a97D-4f4cA:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f7k LACCASE

(uncultured
bacterium) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 ILE A 297
PHE A 244
HIS A 153
VAL A 194
 None
 0.78A 4a97D-4f7kA:
2.9		 4a97D-4f7kA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gnx PUTATIVE
UNCHARACTERIZED
PROTEIN

(Ustilago maydis) 		PF01336
(tRNA_anti-codon) 		4 ILE B 154
GLU B 158
HIS B 149
VAL B 107
 None
 0.89A 4a97D-4gnxB:
undetectable		 4a97D-4gnxB:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ncj DNA DOUBLE-STRAND
BREAK REPAIR RAD50
ATPASE

(Pyrococcus
furiosus) 		PF02463
(SMC_N) 		4 GLU A 786
GLU A 766
PHE A 779
VAL A 157
 None
 1.02A 4a97D-4ncjA:
undetectable		 4a97D-4ncjA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nzr PGT135 HEAVY CHAIN
PROTEIN M TD

(Homo sapiens;
Mycoplasma
genitalium) 		PF07654
(C1-set)
PF07686
(V-set)
no annotation 		4 GLU M 427
ILE M 449
TYR H  32
HIS H  95
 None
 0.71A 4a97D-4nzrM:
undetectable		 4a97D-4nzrM:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pbq PUTATIVE TRAP
PERIPLASMIC SOLUTE
BINDING PROTEIN

(Haemophilus
influenzae) 		PF03480
(DctP) 		4 GLU A 207
PHE A 175
HIS A  32
VAL A  77
 None
2UF  A 401 (-4.5A)
None
None
 0.92A 4a97D-4pbqA:
undetectable		 4a97D-4pbqA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pdb 30S RIBOSOMAL
PROTEIN S8

(Bacillus
anthracis) 		PF00410
(Ribosomal_S8) 		4 GLU A  73
ILE A  75
GLU A  49
PHE A  86
 None
 0.94A 4a97D-4pdbA:
undetectable		 4a97D-4pdbA:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r4g PUTATIVE LIPOPROTEIN
YCDA

(Bacillus
subtilis) 		PF11611
(DUF4352)
PF17118
(DUF5105) 		4 GLU A 354
ILE A 352
TYR A 307
VAL A 284
 None
 1.11A 4a97D-4r4gA:
undetectable		 4a97D-4r4gA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r4g PUTATIVE LIPOPROTEIN
YCDA

(Bacillus
subtilis) 		PF11611
(DUF4352)
PF17118
(DUF5105) 		4 GLU A 354
ILE A 352
TYR A 307
VAL A 300
 None
 0.84A 4a97D-4r4gA:
undetectable		 4a97D-4r4gA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rhh BETA-XYLOSIDASE

(Geobacillus
stearothermophilus) 		PF03512
(Glyco_hydro_52) 		4 GLU A 354
TYR A 316
HIS A  10
VAL A 102
 None
 1.03A 4a97D-4rhhA:
2.5		 4a97D-4rhhA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rs2 PREDICTED
ACYLTRANSFERASE WITH
ACYL-COA
N-ACYLTRANSFERASE
DOMAIN

(Escherichia
coli) 		PF13508
(Acetyltransf_7) 		4 ILE A  14
GLU A   6
HIS A 163
VAL A  62
 None
 0.91A 4a97D-4rs2A:
undetectable		 4a97D-4rs2A:
20.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4twf CYS-LOOP
LIGAND-GATED ION
CHANNEL

(Dickeya
chrysanthemi) 		PF02931
(Neur_chan_LBD) 		5 GLU A  77
ILE A  79
GLU A 131
PHE A 133
TYR A 175
 BR7  A 401 ( 4.9A)
None
BR7  A 401 (-4.1A)
BR7  A 401 (-4.5A)
BR7  A 401 (-3.9A)
 0.54A 4a97D-4twfA:
33.6		 4a97D-4twfA:
99.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x0q DNA POLYMERASE THETA

(Homo sapiens) 		PF00476
(DNA_pol_A) 		4 GLU A2049
ILE A2053
HIS A2236
VAL A2232
 None
None
None
GOL  A2602 (-4.5A)
 1.03A 4a97D-4x0qA:
undetectable		 4a97D-4x0qA:
16.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4yeu CYS-LOOP
LIGAND-GATED ION
CHANNEL,PROTON-GATED
ION CHANNEL

(Dickeya
chrysanthemi;
Gloeobacter
violaceus) 		PF02931
(Neur_chan_LBD) 		6 GLU A  77
ILE A  79
GLU A 131
PHE A 133
TYR A 175
HIS A 177
 None
 0.70A 4a97D-4yeuA:
29.5		 4a97D-4yeuA:
71.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5daj NALD

(Pseudomonas
aeruginosa) 		PF00440
(TetR_N)
PF08361
(TetR_C_2) 		4 ILE A 108
GLU A  20
PHE A  23
VAL A  42
 None
 0.90A 4a97D-5dajA:
4.0		 4a97D-5dajA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dh2 SIDEROPHORE
PERIPLASMIC BINDING
PROTEIN

(Thermobifida
fusca) 		PF01497
(Peripla_BP_2) 		4 GLU A 101
ILE A 118
PHE A 102
TYR A 125
 None
 1.07A 4a97D-5dh2A:
undetectable		 4a97D-5dh2A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dqf SERUM ALBUMIN

(Equus caballus) 		PF00273
(Serum_albumin) 		4 GLU A 229
PHE A 222
TYR A 262
VAL A 240
 None
 1.03A 4a97D-5dqfA:
3.1		 4a97D-5dqfA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ejj UFM1-SPECIFIC
PROTEASE

(Caenorhabditis
elegans) 		PF07910
(Peptidase_C78) 		4 ILE A 367
GLU A 538
TYR A 534
HIS A 533
 None
 0.82A 4a97D-5ejjA:
2.5		 4a97D-5ejjA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fwm HEAT SHOCK PROTEIN
HSP 90 BETA

(Homo sapiens) 		PF00183
(HSP90)
PF02518
(HATPase_c) 		4 ILE A 441
TYR A 457
HIS A 458
VAL A 494
 None
 1.09A 4a97D-5fwmA:
2.0		 4a97D-5fwmA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g4l OXIDOREDUCTASE,
SHORT CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY PROTEIN

(Clostridium sp.) 		PF13561
(adh_short_C2) 		4 GLU A  60
GLU A  64
PHE A  61
VAL A  15
 None
 1.10A 4a97D-5g4lA:
undetectable		 4a97D-5g4lA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ghk SERUM ALBUMIN

(Canis lupus) 		PF00273
(Serum_albumin) 		4 GLU A 230
PHE A 223
TYR A 263
VAL A 241
 None
 0.99A 4a97D-5ghkA:
2.1		 4a97D-5ghkA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i1f UTP--GLUCOSE-1-PHOSP
HATE
URIDYLYLTRANSFERASE

(Burkholderia
vietnamiensis) 		PF00483
(NTP_transferase) 		4 GLU A 161
PHE A 202
TYR A 249
VAL A 149
 None
 1.06A 4a97D-5i1fA:
undetectable		 4a97D-5i1fA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i1f UTP--GLUCOSE-1-PHOSP
HATE
URIDYLYLTRANSFERASE

(Burkholderia
vietnamiensis) 		PF00483
(NTP_transferase) 		4 GLU A 162
GLU A 161
PHE A 202
VAL A 149
 None
 1.01A 4a97D-5i1fA:
undetectable		 4a97D-5i1fA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i8i UREA AMIDOLYASE

(Kluyveromyces
lactis) 		PF00289
(Biotin_carb_N)
PF01425
(Amidase)
PF02626
(CT_A_B)
PF02682
(CT_C_D)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 ILE A1508
GLU A1505
TYR A1445
VAL A1323
 None
 1.03A 4a97D-5i8iA:
3.4		 4a97D-5i8iA:
10.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kvp ZOOCIN A
ENDOPEPTIDASE

(Streptococcus
equi) 		PF01551
(Peptidase_M23) 		4 ILE A  93
PHE A  57
HIS A 120
VAL A  35
 None
 1.08A 4a97D-5kvpA:
undetectable		 4a97D-5kvpA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kz5 CYSTEINE
DESULFURASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00266
(Aminotran_5) 		4 GLU 1 416
TYR 1 317
HIS 1 319
VAL 1 310
 None
 0.94A 4a97D-5kz51:
undetectable		 4a97D-5kz51:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l2q SERINE/THREONINE-PRO
TEIN KINASE 40

(Homo sapiens) 		no annotation 4 ILE C 278
GLU C 281
PHE C 283
VAL C 262
 None
 1.08A 4a97D-5l2qC:
undetectable		 4a97D-5l2qC:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m0k BETA-XYLANASE

(Cellulomonas
flavigena) 		no annotation 4 GLU A  53
PHE A  59
HIS A  81
VAL A  68
 None
 1.02A 4a97D-5m0kA:
undetectable		 4a97D-5m0kA:
12.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mg5 2,4-DIACETYLPHLOROGL
UCINOL BIOSYNTHESIS
PROTEIN PHLC

(Pseudomonas
protegens) 		no annotation 4 ILE C  60
GLU C 116
PHE C  26
VAL C  51
 None
 1.02A 4a97D-5mg5C:
undetectable		 4a97D-5mg5C:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mrj BETA-XYLANASE

(Acremonium
chrysogenum) 		no annotation 4 GLU A 145
PHE A 151
HIS A 173
VAL A 160
 None
 1.08A 4a97D-5mrjA:
undetectable		 4a97D-5mrjA:
9.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o64 REACTION CENTER
PROTEIN H CHAIN

(Blastochloris
viridis) 		PF03967
(PRCH)
PF05239
(PRC) 		5 GLU H 234
ILE H 230
GLU H 235
HIS H  72
VAL H  76
 None
 1.20A 4a97D-5o64H:
undetectable		 4a97D-5o64H:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t1p ABC TRANSPORTER,
PERIPLASMIC
SUBSTRATE-BINDING
PROTEIN

(Campylobacter
jejuni) 		PF13343
(SBP_bac_6) 		4 ILE A  22
GLU A 276
PHE A 277
TYR A 112
 None
 0.99A 4a97D-5t1pA:
undetectable		 4a97D-5t1pA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tch TRYPTOPHAN SYNTHASE
BETA CHAIN

(Mycobacterium
tuberculosis) 		PF00291
(PALP) 		4 GLU B 326
ILE B 252
PHE B  19
VAL B  30
 None
 1.06A 4a97D-5tchB:
undetectable		 4a97D-5tchB:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5td7 ZGC:55652

(Danio rerio) 		PF00850
(Hist_deacetyl) 		4 GLU A  28
TYR A  16
HIS A 103
VAL A  74
 None
 1.00A 4a97D-5td7A:
undetectable		 4a97D-5td7A:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v9x ATP-DEPENDENT DNA
HELICASE

(Mycolicibacterium
smegmatis) 		no annotation 4 GLU A 558
GLU A 554
HIS A 689
VAL A 817
 None
 1.10A 4a97D-5v9xA:
undetectable		 4a97D-5v9xA:
13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wtk CRISPR-ASSOCIATED
ENDORIBONUCLEASE
C2C2

(Leptotrichia
shahii) 		no annotation 4 ILE A1376
GLU A1350
PHE A1325
VAL A1303
 None
 0.89A 4a97D-5wtkA:
2.7		 4a97D-5wtkA:
11.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x6o SERINE/THREONINE-PRO
TEIN KINASE MEC1

(Saccharomyces
cerevisiae) 		no annotation 4 GLU C1568
GLU C1540
TYR C1665
HIS C1625
 None
 1.00A 4a97D-5x6oC:
3.9		 4a97D-5x6oC:
14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z7h LYSR FAMILY
TRANSCRIPTIONAL
REGULATOR

(Staphylococcus
aureus) 		no annotation 4 ILE A 189
GLU A 181
TYR A 204
VAL A 174
 None
 1.08A 4a97D-5z7hA:
undetectable		 4a97D-5z7hA:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zqz TRIFUNCTIONAL ENZYME
SUBUNIT ALPHA,
MITOCHONDRIAL

(Homo sapiens) 		no annotation 4 GLU A 238
ILE A 237
HIS A  40
VAL A  75
 None
 1.06A 4a97D-5zqzA:
undetectable		 4a97D-5zqzA:
12.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6arx ACETYLCHOLINESTERASE

(Anopheles
gambiae) 		no annotation 4 GLU A 400
GLU A 448
TYR A 522
VAL A 694
 None
 1.04A 4a97D-6arxA:
undetectable		 4a97D-6arxA:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bpc RETICULOCYTE BINDING
PROTEIN 2, PUTATIVE

(Plasmodium
vivax) 		no annotation 4 GLU A 255
ILE A 251
GLU A 380
TYR A 177
 None
 0.65A 4a97D-6bpcA:
4.0		 4a97D-6bpcA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d04 RETICULOCYTE BINDING
PROTEIN 2, PUTATIVE

(Plasmodium
vivax) 		no annotation 4 GLU E 255
ILE E 251
GLU E 380
TYR E 177
 None
 0.95A 4a97D-6d04E:
4.0		 4a97D-6d04E:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fkh ATP SYNTHASE SUBUNIT
BETA, CHLOROPLASTIC

(Spinacia
oleracea) 		no annotation 4 GLU D 150
PHE D 149
TYR D 448
VAL D 437
 None
 0.98A 4a97D-6fkhD:
2.3		 4a97D-6fkhD:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g3u -

(-) 		no annotation 4 GLU A 615
ILE A 619
GLU A 616
VAL A 410
 None
 1.06A 4a97D-6g3uA:
undetectable		 4a97D-6g3uA:
undetectable