SIMILAR PATTERNS OF AMINO ACIDS FOR 4A97_C_ZPCC1318_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ao3 VON WILLEBRAND
FACTOR

(Homo sapiens) 		PF00092
(VWA) 		5 VAL A  73
ILE A  33
GLU A  24
ILE A 169
VAL A  45
 None
 1.14A 4a97B-1ao3A:
undetectable
4a97C-1ao3A:
undetectable		 4a97B-1ao3A:
21.82
4a97C-1ao3A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dkg MOLECULAR CHAPERONE
DNAK

(Escherichia
coli) 		PF00012
(HSP70) 		5 VAL D  16
ILE D   5
ILE D  40
GLU D 118
VAL D 135
 None
 1.16A 4a97B-1dkgD:
0.1
4a97C-1dkgD:
0.0		 4a97B-1dkgD:
22.89
4a97C-1dkgD:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dpp DIPEPTIDE BINDING
PROTEIN

(Escherichia
coli) 		PF00496
(SBP_bac_5) 		5 VAL A 504
ILE A 211
GLU A 482
ILE A 254
HIS A 499
 None
 0.99A 4a97B-1dppA:
0.0
4a97C-1dppA:
0.0		 4a97B-1dppA:
18.75
4a97C-1dppA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gz6 ESTRADIOL 17
BETA-DEHYDROGENASE 4

(Rattus
norvegicus) 		PF00106
(adh_short) 		5 VAL A  58
ILE A  62
GLU A 216
TYR A  25
VAL A  36
 None
 1.12A 4a97B-1gz6A:
0.0
4a97C-1gz6A:
0.0		 4a97B-1gz6A:
21.75
4a97C-1gz6A:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jal YCHF PROTEIN

(Haemophilus
influenzae) 		PF01926
(MMR_HSR1)
PF06071
(YchF-GTPase_C) 		5 PHE A 213
ILE A 205
ASN A 207
GLU A 243
VAL A 269
 None
 1.22A 4a97B-1jalA:
2.3
4a97C-1jalA:
2.2		 4a97B-1jalA:
22.05
4a97C-1jalA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k32 TRICORN PROTEASE

(Thermoplasma
acidophilum) 		PF03572
(Peptidase_S41)
PF07676
(PD40)
PF14684
(Tricorn_C1)
PF14685
(Tricorn_PDZ) 		5 VAL A  75
ILE A  95
GLU A 312
ILE A 308
VAL A  97
 None
 1.34A 4a97B-1k32A:
0.0
4a97C-1k32A:
2.9		 4a97B-1k32A:
15.06
4a97C-1k32A:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qni NITROUS-OXIDE
REDUCTASE

(Marinobacter
hydrocarbonoclasticus) 		no annotation 5 VAL A 105
ILE A 170
ILE A 440
GLU A 383
HIS A 128
 None
None
None
None
CUZ  A 801 (-3.1A)
 1.25A 4a97B-1qniA:
0.0
4a97C-1qniA:
0.0		 4a97B-1qniA:
18.04
4a97C-1qniA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uf2 CORE PROTEIN P3

(Rice dwarf
virus) 		PF09231
(RDV-p3) 		5 ILE A 138
GLU A 212
TYR A 217
HIS A 218
VAL A 983
 None
 1.17A 4a97B-1uf2A:
0.9
4a97C-1uf2A:
1.0		 4a97B-1uf2A:
15.35
4a97C-1uf2A:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wps HUT OPERON POSITIVE
REGULATORY PROTEIN

(Bacillus
subtilis) 		PF09021
(HutP) 		5 VAL A  50
ILE A  54
ILE A 129
HIS A  84
VAL A 123
 None
 1.32A 4a97B-1wpsA:
0.0
4a97C-1wpsA:
undetectable		 4a97B-1wpsA:
19.18
4a97C-1wpsA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yaa ASPARTATE
AMINOTRANSFERASE

(Saccharomyces
cerevisiae) 		PF00155
(Aminotran_1_2) 		5 VAL A 103
ILE A 101
GLU A 294
ILE A 146
VAL A 283
 None
 1.00A 4a97B-1yaaA:
undetectable
4a97C-1yaaA:
undetectable		 4a97B-1yaaA:
22.17
4a97C-1yaaA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cjs UNC-13 HOMOLOG A

(Rattus
norvegicus) 		PF00168
(C2) 		5 PHE A  49
VAL A   8
ILE A 121
ILE A  53
VAL A  64
 None
 0.99A 4a97B-2cjsA:
undetectable
4a97C-2cjsA:
undetectable		 4a97B-2cjsA:
19.74
4a97C-2cjsA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eyq TRANSCRIPTION-REPAIR
COUPLING FACTOR

(Escherichia
coli) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF02559
(CarD_CdnL_TRCF)
PF03461
(TRCF) 		5 PHE A 734
VAL A 728
ILE A 751
GLU A 957
HIS A 738
 None
 1.28A 4a97B-2eyqA:
undetectable
4a97C-2eyqA:
undetectable		 4a97B-2eyqA:
13.36
4a97C-2eyqA:
13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hjh NAD-DEPENDENT
HISTONE DEACETYLASE
SIR2

(Saccharomyces
cerevisiae) 		PF02146
(SIR2)
PF04574
(DUF592) 		5 PHE A 241
VAL A 493
ILE A 495
GLU A 545
VAL A 520
 None
 1.06A 4a97B-2hjhA:
undetectable
4a97C-2hjhA:
undetectable		 4a97B-2hjhA:
22.96
4a97C-2hjhA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hru PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE II

(Thermotoga
maritima) 		PF00586
(AIRS)
PF02769
(AIRS_C)
PF16904
(PurL_C) 		5 VAL A 231
ILE A 297
ILE A  92
GLU A 215
VAL A 176
 None
 1.31A 4a97B-2hruA:
undetectable
4a97C-2hruA:
undetectable		 4a97B-2hruA:
20.68
4a97C-2hruA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jf3 ACYL-[ACYL-CARRIER-P
ROTEIN]--UDP-N-ACETY
LGLUCOSAMINE
O-ACYLTRANSFERASE

(Escherichia
coli) 		PF00132
(Hexapep)
PF13720
(Acetyltransf_11) 		5 VAL A  50
ILE A  68
ILE A   2
HIS A  35
VAL A  84
 None
 1.34A 4a97B-2jf3A:
undetectable
4a97C-2jf3A:
undetectable		 4a97B-2jf3A:
19.51
4a97C-2jf3A:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jjy ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE

(Francisella
tularensis) 		PF13561
(adh_short_C2) 		5 ILE A 192
GLU A 150
TYR A 251
HIS A 246
VAL A 220
 None
 1.22A 4a97B-2jjyA:
undetectable
4a97C-2jjyA:
undetectable		 4a97B-2jjyA:
21.99
4a97C-2jjyA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kho HEAT SHOCK PROTEIN
70

(Escherichia
coli) 		PF00012
(HSP70) 		5 VAL A  16
ILE A   5
ILE A  40
GLU A 118
VAL A 135
 None
 1.18A 4a97B-2khoA:
2.9
4a97C-2khoA:
2.9		 4a97B-2khoA:
19.32
4a97C-2khoA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ph5 HOMOSPERMIDINE
SYNTHASE

(Legionella
pneumophila) 		PF03435
(Sacchrp_dh_NADP)
PF16653
(Sacchrp_dh_C) 		5 VAL A 317
ILE A 203
GLU A 417
HIS A 293
VAL A 361
 None
 1.30A 4a97B-2ph5A:
undetectable
4a97C-2ph5A:
undetectable		 4a97B-2ph5A:
20.61
4a97C-2ph5A:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qdl CHEMOTAXIS SIGNAL
TRANSDUCTION PROTEIN

(Caldanaerobacter
subterraneus) 		PF01584
(CheW) 		5 VAL A  31
ILE A  84
GLU A 126
ILE A 111
VAL A 100
 None
None
None
None
GOL  A 166 ( 4.1A)
 1.09A 4a97B-2qdlA:
undetectable
4a97C-2qdlA:
undetectable		 4a97B-2qdlA:
18.77
4a97C-2qdlA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r9h H(+)/CL(-) EXCHANGE
TRANSPORTER CLCA

(Escherichia
coli) 		PF00654
(Voltage_CLC) 		5 VAL A 218
ILE A 215
ILE A 109
GLU A 203
HIS A 175
 None
None
CL  A   2 ( 4.9A)
None
None
 1.28A 4a97B-2r9hA:
2.3
4a97C-2r9hA:
2.3		 4a97B-2r9hA:
21.59
4a97C-2r9hA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rhq PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN

(Staphylococcus
haemolyticus) 		PF01409
(tRNA-synt_2d) 		5 ILE A 284
GLU A 118
GLU A 347
TYR A 324
VAL A 277
 None
 1.01A 4a97B-2rhqA:
undetectable
4a97C-2rhqA:
undetectable		 4a97B-2rhqA:
19.45
4a97C-2rhqA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v5g YSCU

(Yersinia
enterocolitica) 		PF01312
(Bac_export_2) 		5 VAL A 283
ILE A 271
GLU A 227
GLU A 329
VAL A 261
 None
 1.09A 4a97B-2v5gA:
undetectable
4a97C-2v5gA:
undetectable		 4a97B-2v5gA:
19.05
4a97C-2v5gA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w87 ESTERASE D

(Cellvibrio
japonicus) 		PF03422
(CBM_6) 		5 VAL A 118
ILE A  53
ILE A  26
GLU A  14
VAL A 136
 None
None
None
CA  A1149 (-2.2A)
None
 1.04A 4a97B-2w87A:
undetectable
4a97C-2w87A:
undetectable		 4a97B-2w87A:
18.03
4a97C-2w87A:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wtb FATTY ACID
MULTIFUNCTIONAL
PROTEIN (ATMFP2)

(Arabidopsis
thaliana) 		PF00378
(ECH_1)
PF00725
(3HCDH)
PF02737
(3HCDH_N) 		5 VAL A 446
ILE A 473
ILE A 317
HIS A 449
VAL A 489
 None
 1.31A 4a97B-2wtbA:
undetectable
4a97C-2wtbA:
undetectable		 4a97B-2wtbA:
17.37
4a97C-2wtbA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xvo SSO1725

(Sulfolobus
solfataricus) 		no annotation 5 PHE A 102
VAL A  72
ILE A 186
ILE A  87
TYR A  25
 None
 1.12A 4a97B-2xvoA:
undetectable
4a97C-2xvoA:
undetectable		 4a97B-2xvoA:
23.20
4a97C-2xvoA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y7l AGGLUTININ-LIKE ALS9
PROTEIN

(Candida
albicans) 		PF11766
(Candida_ALS_N) 		5 ILE A 214
ASN A 213
GLU A  86
ILE A 173
VAL A 245
 None
 1.26A 4a97B-2y7lA:
2.6
4a97C-2y7lA:
2.6		 4a97B-2y7lA:
19.71
4a97C-2y7lA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z51 NIFU-LIKE PROTEIN 2,
CHLOROPLAST

(Arabidopsis
thaliana) 		PF01106
(NifU) 		5 VAL A  27
ILE A  59
GLU A   7
HIS A  30
VAL A  73
 None
 1.01A 4a97B-2z51A:
undetectable
4a97C-2z51A:
undetectable		 4a97B-2z51A:
17.59
4a97C-2z51A:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zyg 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING

(Klebsiella
pneumoniae) 		PF00393
(6PGD)
PF03446
(NAD_binding_2) 		5 ILE A  22
GLU A  45
GLU A 132
GLU A 131
VAL A   8
 None
 1.01A 4a97B-2zygA:
2.0
4a97C-2zygA:
2.2		 4a97B-2zygA:
21.27
4a97C-2zygA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b0q PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 PHE A 368
VAL A 339
ILE A 341
GLU A 365
ILE A 445
 None
MC5  A   1 (-4.6A)
MC5  A   1 (-4.5A)
None
None
 1.27A 4a97B-3b0qA:
undetectable
4a97C-3b0qA:
undetectable		 4a97B-3b0qA:
20.00
4a97C-3b0qA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b49 LIN2189 PROTEIN

(Listeria
innocua) 		PF06445
(GyrI-like) 		5 ILE A  60
GLU A  12
ILE A 186
GLU A  82
VAL A 111
 None
 1.26A 4a97B-3b49A:
undetectable
4a97C-3b49A:
undetectable		 4a97B-3b49A:
21.20
4a97C-3b49A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b49 LIN2189 PROTEIN

(Listeria
innocua) 		PF06445
(GyrI-like) 		5 PHE A   8
ILE A  60
GLU A  12
ILE A 186
VAL A 111
 None
 1.06A 4a97B-3b49A:
undetectable
4a97C-3b49A:
undetectable		 4a97B-3b49A:
21.20
4a97C-3b49A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bga BETA-GALACTOSIDASE

(Bacteroides
thetaiotaomicron) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF02929
(Bgal_small_N)
PF16353
(DUF4981) 		5 ARG A 892
ILE A 907
GLU A 632
ILE A 636
VAL A 738
 None
 1.34A 4a97B-3bgaA:
3.0
4a97C-3bgaA:
3.0		 4a97B-3bgaA:
14.50
4a97C-3bgaA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cdd PROPHAGE MUSO2, 43
KDA TAIL PROTEIN

(Shewanella
oneidensis) 		PF05954
(Phage_GPD) 		5 PHE A 142
ILE A 178
ILE A 147
GLU A 151
VAL A 166
 None
 1.16A 4a97B-3cddA:
undetectable
4a97C-3cddA:
undetectable		 4a97B-3cddA:
22.08
4a97C-3cddA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dcl TM1086

(Thermotoga
maritima) 		PF14505
(DUF4438) 		5 VAL A 256
ILE A  84
ASN A 151
ILE A  76
HIS A 106
 None
 1.20A 4a97B-3dclA:
undetectable
4a97C-3dclA:
undetectable		 4a97B-3dclA:
21.10
4a97C-3dclA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dzu PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep)
PF00105
(zf-C4) 		5 PHE D 368
VAL D 339
ILE D 341
GLU D 365
ILE D 445
 None
None
PLB  D 701 (-3.6A)
None
None
 1.16A 4a97B-3dzuD:
undetectable
4a97C-3dzuD:
undetectable		 4a97B-3dzuD:
21.48
4a97C-3dzuD:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3egc PUTATIVE RIBOSE
OPERON REPRESSOR

(Burkholderia
thailandensis) 		PF00532
(Peripla_BP_1) 		5 PHE A  81
VAL A 152
ILE A 128
GLU A 107
VAL A  89
 None
 1.33A 4a97B-3egcA:
undetectable
4a97C-3egcA:
undetectable		 4a97B-3egcA:
21.60
4a97C-3egcA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f3b PHAGE-LIKE ELEMENT
PBSX PROTEIN XKDH

(Bacillus
subtilis) 		PF12206
(DUF3599) 		5 PHE A  52
ILE A  13
TYR A  51
HIS A   9
VAL A  48
 None
None
None
PO4  A 127 (-3.5A)
None
 1.29A 4a97B-3f3bA:
undetectable
4a97C-3f3bA:
undetectable		 4a97B-3f3bA:
18.84
4a97C-3f3bA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gpg NON-STRUCTURAL
PROTEIN 3

(Chikungunya
virus) 		PF01661
(Macro) 		5 VAL A  19
ILE A  11
ASN A  14
GLU A  43
VAL A  33
 None
 1.21A 4a97B-3gpgA:
undetectable
4a97C-3gpgA:
undetectable		 4a97B-3gpgA:
18.24
4a97C-3gpgA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gyr PHENOXAZINONE
SYNTHASE

(Streptomyces
antibioticus) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 VAL A 588
GLU A 461
TYR A 601
HIS A 527
VAL A 580
 None
None
None
CU  A1004 ( 3.2A)
None
 1.17A 4a97B-3gyrA:
undetectable
4a97C-3gyrA:
undetectable		 4a97B-3gyrA:
19.90
4a97C-3gyrA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h5l PUTATIVE
BRANCHED-CHAIN AMINO
ACID ABC TRANSPORTER

(Ruegeria
pomeroyi) 		PF13458
(Peripla_BP_6) 		5 VAL A 252
ILE A 197
GLU A 183
TYR A 219
VAL A 223
 None
 1.24A 4a97B-3h5lA:
undetectable
4a97C-3h5lA:
undetectable		 4a97B-3h5lA:
21.18
4a97C-3h5lA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jzj ACARBOSE/MALTOSE
BINDING PROTEIN GACH

(Streptomyces
glaucescens) 		PF13416
(SBP_bac_8) 		5 PHE A  24
VAL A  79
GLU A  46
TYR A 310
VAL A 128
 None
 1.35A 4a97B-3jzjA:
undetectable
4a97C-3jzjA:
undetectable		 4a97B-3jzjA:
19.42
4a97C-3jzjA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ki8 BETA
UREIDOPROPIONASE
(BETA-ALANINE
SYNTHASE)

(Pyrococcus
abyssi) 		PF00795
(CN_hydrolase) 		5 VAL A 190
ASN A 188
GLU A 153
HIS A 168
VAL A 133
 None
 1.34A 4a97B-3ki8A:
undetectable
4a97C-3ki8A:
undetectable		 4a97B-3ki8A:
21.45
4a97C-3ki8A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3klq PUTATIVE PILUS
ANCHORING PROTEIN

(Streptococcus
pyogenes) 		PF12892
(FctA) 		5 PHE A 115
VAL A  11
ILE A   9
TYR A  66
VAL A  84
 None
 1.05A 4a97B-3klqA:
undetectable
4a97C-3klqA:
undetectable		 4a97B-3klqA:
18.12
4a97C-3klqA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ld1 REPLICASE
POLYPROTEIN 1A

(Avian
coronavirus) 		no annotation 5 PHE A 185
VAL A 158
ILE A 216
ILE A 202
VAL A 227
 None
 1.16A 4a97B-3ld1A:
undetectable
4a97C-3ld1A:
undetectable		 4a97B-3ld1A:
21.88
4a97C-3ld1A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3led 3-OXOACYL-ACYL
CARRIER PROTEIN
SYNTHASE III

(Rhodopseudomonas
palustris) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		5 PHE A 367
ILE A 306
ILE A   6
HIS A 279
VAL A 272
 None
 1.30A 4a97B-3ledA:
undetectable
4a97C-3ledA:
undetectable		 4a97B-3ledA:
25.93
4a97C-3ledA:
25.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n6r PROPIONYL-COA
CARBOXYLASE, ALPHA
SUBUNIT

(Ruegeria
pomeroyi) 		PF00289
(Biotin_carb_N)
PF00364
(Biotin_lipoyl)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		5 PHE A 494
VAL A 300
ASN A 398
GLU A 464
VAL A 360
 None
 1.31A 4a97B-3n6rA:
undetectable
4a97C-3n6rA:
undetectable		 4a97B-3n6rA:
18.80
4a97C-3n6rA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3opy 6-PHOSPHOFRUCTO-1-KI
NASE ALPHA-SUBUNIT

(Komagataella
pastoris) 		PF00365
(PFK) 		5 VAL A 309
ILE A 215
GLU A 521
ILE A 538
VAL A 243
 None
 1.34A 4a97B-3opyA:
undetectable
4a97C-3opyA:
undetectable		 4a97B-3opyA:
15.71
4a97C-3opyA:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p8a UNCHARACTERIZED
PROTEIN

(Staphylococcus
aureus) 		PF13468
(Glyoxalase_3) 		5 PHE A 107
VAL A 248
ILE A 191
ILE A 162
HIS A  30
 None
None
None
CL  A 278 (-4.8A)
None
 1.35A 4a97B-3p8aA:
undetectable
4a97C-3p8aA:
undetectable		 4a97B-3p8aA:
21.15
4a97C-3p8aA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3plr UDP-GLUCOSE
6-DEHYDROGENASE

(Klebsiella
pneumoniae) 		PF00984
(UDPG_MGDP_dh)
PF03720
(UDPG_MGDP_dh_C)
PF03721
(UDPG_MGDP_dh_N) 		5 PHE A 170
ILE A   5
ASN A  15
ILE A 183
VAL A  25
 None
 1.33A 4a97B-3plrA:
undetectable
4a97C-3plrA:
undetectable		 4a97B-3plrA:
20.56
4a97C-3plrA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3prl NADP-DEPENDENT
GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE

(Bacillus
halodurans) 		PF00171
(Aldedh) 		5 VAL A 199
ILE A 173
GLU A  98
ILE A  31
VAL A 183
 None
 1.03A 4a97B-3prlA:
undetectable
4a97C-3prlA:
undetectable		 4a97B-3prlA:
20.63
4a97C-3prlA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3psg PEPSINOGEN

(Sus scrofa) 		PF00026
(Asp)
PF07966
(A1_Propeptide) 		5 PHE A 151
VAL A 153
ILE A 306
ILE A  18
VAL A 214
 None
 1.27A 4a97B-3psgA:
undetectable
4a97C-3psgA:
undetectable		 4a97B-3psgA:
21.96
4a97C-3psgA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pvl MYOSIN VIIA ISOFORM
1

(Mus musculus) 		PF00784
(MyTH4) 		5 PHE A1513
VAL A1556
ILE A1552
ILE A1537
VAL A1491
 None
 1.07A 4a97B-3pvlA:
undetectable
4a97C-3pvlA:
undetectable		 4a97B-3pvlA:
19.64
4a97C-3pvlA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q9o EXOTOXIN A

(Vibrio cholerae) 		PF09009
(Exotox-A_cataly)
PF09101
(Exotox-A_bind)
PF09102
(Exotox-A_target) 		5 VAL A 434
ILE A 429
GLU A 617
ILE A 609
VAL A 471
 None
 1.10A 4a97B-3q9oA:
undetectable
4a97C-3q9oA:
undetectable		 4a97B-3q9oA:
18.53
4a97C-3q9oA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q9t CHOLINE
DEHYDROGENASE AND
RELATED
FLAVOPROTEINS

(Aspergillus
oryzae) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		5 PHE A 454
VAL A 504
ILE A 467
GLU A 371
VAL A 422
 None
 1.04A 4a97B-3q9tA:
undetectable
4a97C-3q9tA:
undetectable		 4a97B-3q9tA:
20.80
4a97C-3q9tA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qjp PUTATIVE
UNCHARACTERIZED
PROTEIN PH0350

(Pyrococcus
horikoshii) 		PF01881
(Cas_Cas6) 		5 PHE A  52
ILE A 200
ILE A  56
TYR A  20
VAL A 195
 None
None
U  R   3 ( 4.5A)
None
None
 1.26A 4a97B-3qjpA:
undetectable
4a97C-3qjpA:
undetectable		 4a97B-3qjpA:
20.50
4a97C-3qjpA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s51 FANCONI ANEMIA GROUP
I PROTEIN HOMOLOG

(Mus musculus) 		PF14674
(FANCI_S1-cap)
PF14675
(FANCI_S1)
PF14676
(FANCI_S2)
PF14677
(FANCI_S3)
PF14678
(FANCI_S4)
PF14679
(FANCI_HD1)
PF14680
(FANCI_HD2) 		5 ILE A 210
GLU A 247
TYR A 265
HIS A 266
VAL A 271
 None
 1.15A 4a97B-3s51A:
5.3
4a97C-3s51A:
4.9		 4a97B-3s51A:
12.18
4a97C-3s51A:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s5k FALCILYSIN

(Plasmodium
falciparum) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C)
PF08367
(M16C_assoc) 		5 VAL A 187
ILE A 184
GLU A 632
ILE A 203
GLU A 207
 None
 1.18A 4a97B-3s5kA:
2.1
4a97C-3s5kA:
2.0		 4a97B-3s5kA:
14.52
4a97C-3s5kA:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sbq NITROUS-OXIDE
REDUCTASE

(Pseudomonas
stutzeri) 		no annotation 5 VAL A 155
ILE A 222
ILE A 497
GLU A 440
HIS A 178
 None
None
None
None
CUK  A 702 (-3.1A)
 1.19A 4a97B-3sbqA:
undetectable
4a97C-3sbqA:
undetectable		 4a97B-3sbqA:
19.40
4a97C-3sbqA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ssz MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME,
N-TERMINAL DOMAIN
PROTEIN

(Rhodobacteraceae
bacterium KLH11) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 ILE A 325
GLU A 359
ILE A 169
HIS A 339
VAL A 316
 None
None
None
SO4  A 414 ( 4.7A)
None
 1.16A 4a97B-3sszA:
undetectable
4a97C-3sszA:
undetectable		 4a97B-3sszA:
19.95
4a97C-3sszA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3stp GALACTONATE
DEHYDRATASE,
PUTATIVE

(Labrenzia
aggregata) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 ILE A 302
GLU A 336
ILE A 146
HIS A 316
VAL A 293
 None
 1.20A 4a97B-3stpA:
undetectable
4a97C-3stpA:
undetectable		 4a97B-3stpA:
19.64
4a97C-3stpA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3upy OXIDOREDUCTASE

(Brucella
abortus) 		PF03447
(NAD_binding_3) 		5 VAL A 329
ILE A  38
GLU A 168
GLU A 141
HIS A 323
 None
None
FOM  A 447 ( 2.4A)
None
FOM  A 447 (-4.1A)
 1.28A 4a97B-3upyA:
undetectable
4a97C-3upyA:
undetectable		 4a97B-3upyA:
19.82
4a97C-3upyA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vxi DYP

(Bjerkandera
adusta) 		PF04261
(Dyp_perox) 		5 ILE A 393
GLU A 337
GLU A 254
HIS A 166
VAL A 420
 None
None
None
None
HEM  A 501 ( 4.5A)
 1.20A 4a97B-3vxiA:
undetectable
4a97C-3vxiA:
undetectable		 4a97B-3vxiA:
21.78
4a97C-3vxiA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w3a V-TYPE ATP SYNTHASE
ALPHA CHAIN

(Thermus
thermophilus) 		PF00006
(ATP-synt_ab)
PF02874
(ATP-synt_ab_N)
PF16886
(ATP-synt_ab_Xtn) 		5 VAL A 251
ILE A 288
GLU A 140
TYR A 312
VAL A 305
 None
 0.91A 4a97B-3w3aA:
2.5
4a97C-3w3aA:
2.6		 4a97B-3w3aA:
19.22
4a97C-3w3aA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wsv L-LACTATE
DEHYDROGENASE

(Enterococcus
mundtii) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 ILE A 159
GLU A 208
GLU A 201
HIS A 188
VAL A 170
 None
 1.33A 4a97B-3wsvA:
undetectable
4a97C-3wsvA:
undetectable		 4a97B-3wsvA:
22.64
4a97C-3wsvA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ziu LEUCYL-TRNA
SYNTHETASE

(Mycoplasma
mobile) 		PF00133
(tRNA-synt_1)
PF08264
(Anticodon_1) 		5 ILE A  81
GLU A 366
ILE A 403
GLU A  58
HIS A 367
 None
LSS  A1638 (-3.0A)
LSS  A1638 (-4.2A)
LSS  A1638 (-4.4A)
LSS  A1638 (-3.8A)
 1.19A 4a97B-3ziuA:
2.8
4a97C-3ziuA:
2.9		 4a97B-3ziuA:
18.65
4a97C-3ziuA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4acq ALPHA-2-MACROGLOBULI
N

(Homo sapiens) 		PF00207
(A2M)
PF01835
(A2M_N)
PF07678
(A2M_comp)
PF07703
(A2M_N_2)
PF10569
(Thiol-ester_cl) 		5 PHE A 300
VAL A 266
ILE A 268
TYR A 301
VAL A 304
 None
 0.97A 4a97B-4acqA:
3.5
4a97C-4acqA:
3.5		 4a97B-4acqA:
11.67
4a97C-4acqA:
11.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aw7 GH86A
BETA-PORPHYRANASE

(Bacteroides
plebeius) 		no annotation 5 VAL A 391
ILE A 389
GLU A 593
ILE A 478
VAL A 414
 None
 1.19A 4a97B-4aw7A:
undetectable
4a97C-4aw7A:
undetectable		 4a97B-4aw7A:
19.62
4a97C-4aw7A:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ffu OXIDASE

(Sinorhizobium
meliloti) 		PF01575
(MaoC_dehydratas) 		5 VAL A  79
ASN A  77
GLU A   9
GLU A 123
ILE A 106
 None
 1.23A 4a97B-4ffuA:
undetectable
4a97C-4ffuA:
undetectable		 4a97B-4ffuA:
19.68
4a97C-4ffuA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h9k HOG CHOLERA VIRUS

(Pestivirus C) 		PF05550
(Peptidase_C53) 		5 VAL A 121
ILE A 131
GLU A 104
HIS A  99
VAL A  83
 None
 1.21A 4a97B-4h9kA:
undetectable
4a97C-4h9kA:
undetectable		 4a97B-4h9kA:
18.89
4a97C-4h9kA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ida RIPENING-INDUCED
PROTEIN

(Fragaria vesca) 		PF08240
(ADH_N)
PF13602
(ADH_zinc_N_2) 		5 ASN A 135
GLU A 274
ILE A 148
TYR A 101
HIS A 131
 None
 1.05A 4a97B-4idaA:
undetectable
4a97C-4idaA:
undetectable		 4a97B-4idaA:
22.31
4a97C-4idaA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jn6 4-HYDROXY-2-OXOVALER
ATE ALDOLASE

(Mycobacterium
tuberculosis) 		PF00682
(HMGL-like)
PF07836
(DmpG_comm) 		5 PHE A 137
VAL A 135
ILE A 107
HIS A 198
VAL A  44
 OXL  A 401 (-4.5A)
None
None
MN  A 402 ( 3.5A)
None
 1.24A 4a97B-4jn6A:
undetectable
4a97C-4jn6A:
undetectable		 4a97B-4jn6A:
20.79
4a97C-4jn6A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kgb SUCCINYL-COA:3-KETOA
CID-COENZYME A
TRANSFERASE

(Drosophila
melanogaster) 		PF01144
(CoA_trans) 		5 VAL A 400
ILE A 462
GLU A 438
GLU A 468
VAL A 474
 None
 1.32A 4a97B-4kgbA:
undetectable
4a97C-4kgbA:
undetectable		 4a97B-4kgbA:
22.11
4a97C-4kgbA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mo9 PERIPLASMIC BINDING
PROTEIN

(Veillonella
parvula) 		PF01497
(Peripla_BP_2) 		5 ARG A 293
ILE A 257
GLU A 209
GLU A 210
HIS A 312
 None
 1.33A 4a97B-4mo9A:
1.6
4a97C-4mo9A:
1.6		 4a97B-4mo9A:
22.98
4a97C-4mo9A:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nnb OBCA, OXALATE
BIOSYNTHETIC
COMPONENT A

(Burkholderia
glumae) 		PF05853
(BKACE) 		5 VAL A 306
ILE A 271
ASN A 273
GLU A 473
VAL A 517
 None
None
None
MG  A 601 ( 2.6A)
None
 1.02A 4a97B-4nnbA:
undetectable
4a97C-4nnbA:
undetectable		 4a97B-4nnbA:
21.28
4a97C-4nnbA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pzc 3-HYDROXYACYL-COA
DEHYDROGENASE

(Cupriavidus
necator) 		PF00725
(3HCDH)
PF02737
(3HCDH_N) 		5 PHE A 142
VAL A 189
ASN A 190
GLU A  92
VAL A 181
 None
 1.26A 4a97B-4pzcA:
undetectable
4a97C-4pzcA:
undetectable		 4a97B-4pzcA:
22.66
4a97C-4pzcA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r37 PUTATIVE
ACYL-[ACYL-CARRIER-P
ROTEIN]--UDP-N-ACETY
LGLUCOSAMINE
O-ACYLTRANSFERASE

(Bacteroides
fragilis) 		PF00132
(Hexapep)
PF13720
(Acetyltransf_11) 		5 ILE A  50
GLU A  11
GLU A  75
TYR A  46
HIS A   9
 None
None
PE5  A1002 (-3.7A)
None
None
 1.32A 4a97B-4r37A:
undetectable
4a97C-4r37A:
undetectable		 4a97B-4r37A:
20.99
4a97C-4r37A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1

(Homo sapiens;
synthetic
construct) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		5 PHE A3243
ILE A3211
GLU A3196
GLU A3249
VAL A2878
 None
 1.29A 4a97B-4rh7A:
undetectable
4a97C-4rh7A:
undetectable		 4a97B-4rh7A:
6.68
4a97C-4rh7A:
6.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4udn PERIPLASMIC SOLUTE
BINDING PROTEIN

(Candidatus
Liberibacter
asiaticus) 		PF01297
(ZnuA) 		5 VAL A 169
ILE A 218
GLU A  95
HIS A 205
VAL A 232
 None
None
GOL  A1282 (-3.1A)
GOL  A1281 (-4.6A)
None
 1.33A 4a97B-4udnA:
undetectable
4a97C-4udnA:
undetectable		 4a97B-4udnA:
22.77
4a97C-4udnA:
22.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4yeu CYS-LOOP
LIGAND-GATED ION
CHANNEL,PROTON-GATED
ION CHANNEL

(Dickeya
chrysanthemi;
Gloeobacter
violaceus) 		PF02931
(Neur_chan_LBD) 		5 GLU A  77
ILE A  79
GLU A 131
TYR A 175
HIS A 177
 None
 0.78A 4a97B-4yeuA:
27.0
4a97C-4yeuA:
29.4		 4a97B-4yeuA:
71.88
4a97C-4yeuA:
71.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4yeu CYS-LOOP
LIGAND-GATED ION
CHANNEL,PROTON-GATED
ION CHANNEL

(Dickeya
chrysanthemi;
Gloeobacter
violaceus) 		PF02931
(Neur_chan_LBD) 		5 PHE A  19
VAL A  40
ARG A  91
ILE A 101
ASN A 103
 None
 0.48A 4a97B-4yeuA:
27.0
4a97C-4yeuA:
29.4		 4a97B-4yeuA:
71.88
4a97C-4yeuA:
71.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a9d SOLUTE CARRIER
FAMILY 15 MEMBER 1

(Mus musculus) 		no annotation 5 PHE A 455
VAL A 451
ILE A 440
HIS A 461
VAL A 465
 None
 1.27A 4a97B-5a9dA:
undetectable
4a97C-5a9dA:
undetectable		 4a97B-5a9dA:
20.58
4a97C-5a9dA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bqm SOMATOLIBERIN,BOTULI
NUM NEUROTOXIN TYPE
D

(Clostridium
botulinum;
Homo sapiens) 		PF07952
(Toxin_trans) 		5 VAL B 630
ILE B 700
GLU B 723
TYR B 605
VAL B 513
 None
 1.25A 4a97B-5bqmB:
3.6
4a97C-5bqmB:
undetectable		 4a97B-5bqmB:
20.74
4a97C-5bqmB:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cee NAD-DEPENDENT MALIC
ENZYME

(Aster yellows
witches'-broom
phytoplasma) 		PF00390
(malic)
PF03949
(Malic_M) 		5 PHE A 156
VAL A 323
GLU A 144
HIS A 161
VAL A 166
 None
 1.09A 4a97B-5ceeA:
undetectable
4a97C-5ceeA:
undetectable		 4a97B-5ceeA:
19.01
4a97C-5ceeA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cee NAD-DEPENDENT MALIC
ENZYME

(Aster yellows
witches'-broom
phytoplasma) 		PF00390
(malic)
PF03949
(Malic_M) 		5 PHE A 156
VAL A 323
ILE A 374
GLU A 144
HIS A 161
 None
 1.28A 4a97B-5ceeA:
undetectable
4a97C-5ceeA:
undetectable		 4a97B-5ceeA:
19.01
4a97C-5ceeA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fjn L-AMINO ACID
DEAMINASE

(Cosenzaea
myxofaciens) 		PF01266
(DAO) 		5 PHE A 264
VAL A 228
GLU A  92
ILE A 259
VAL A  59
 None
FAD  A 500 (-3.8A)
FAD  A 500 (-3.5A)
None
None
 1.20A 4a97B-5fjnA:
undetectable
4a97C-5fjnA:
undetectable		 4a97B-5fjnA:
20.59
4a97C-5fjnA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hcc COMPLEMENT C5

(Homo sapiens) 		PF01835
(A2M_N)
PF07703
(A2M_N_2) 		5 PHE B 111
VAL B 106
ILE B  54
HIS B 110
VAL B  71
 None
 1.16A 4a97B-5hccB:
undetectable
4a97C-5hccB:
undetectable		 4a97B-5hccB:
19.15
4a97C-5hccB:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hkq CONTACT-DEPENDENT
INHIBITOR A

(Escherichia
coli) 		PF14436
(EndoU_bacteria) 		5 VAL A 234
ILE A 220
ILE A 268
HIS A 204
VAL A 213
 None
 1.05A 4a97B-5hkqA:
undetectable
4a97C-5hkqA:
undetectable		 4a97B-5hkqA:
17.11
4a97C-5hkqA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hzr SNF2-FAMILY ATP
DEPENDENT CHROMATIN
REMODELING FACTOR
LIKE PROTEIN

(Thermothelomyces
thermophila) 		PF00176
(SNF2_N)
PF00271
(Helicase_C)
PF14619
(SnAC) 		5 PHE A 943
VAL A 892
ILE A 965
GLU A1073
ILE A1076
 None
 1.16A 4a97B-5hzrA:
undetectable
4a97C-5hzrA:
undetectable		 4a97B-5hzrA:
17.42
4a97C-5hzrA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jcn OS09G0567300 PROTEIN

(Oryza sativa) 		PF07992
(Pyr_redox_2) 		5 VAL A 296
ILE A 120
GLU A  47
TYR A  20
VAL A 327
 None
 1.27A 4a97B-5jcnA:
undetectable
4a97C-5jcnA:
undetectable		 4a97B-5jcnA:
19.18
4a97C-5jcnA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jo7 VETISPIRADIENE
SYNTHASE 1

(Hyoscyamus
muticus) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		5 ILE A 133
GLU A  78
GLU A 160
HIS A 125
VAL A 129
 None
 1.28A 4a97B-5jo7A:
undetectable
4a97C-5jo7A:
undetectable		 4a97B-5jo7A:
19.92
4a97C-5jo7A:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jt8 BLO T 1 ALLERGEN

(Blomia
tropicalis) 		PF00112
(Peptidase_C1)
PF08246
(Inhibitor_I29) 		5 VAL A 265
ILE A 281
ASN A 283
HIS A 237
VAL A 297
 None
 1.11A 4a97B-5jt8A:
undetectable
4a97C-5jt8A:
undetectable		 4a97B-5jt8A:
22.73
4a97C-5jt8A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mp2 TYPE II SECRETION
SYSTEM PROTEIN D

(Pseudomonas
aeruginosa) 		no annotation 6 VAL A  89
ILE A  55
GLU A 195
ILE A 198
HIS A 172
VAL A 100
 None
 1.44A 4a97B-5mp2A:
undetectable
4a97C-5mp2A:
undetectable		 4a97B-5mp2A:
14.38
4a97C-5mp2A:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mqc VP2

(Black queen
cell virus) 		PF00073
(Rhv) 		5 PHE B 210
VAL B 212
ILE B 114
ILE B 163
VAL B 194
 None
 1.10A 4a97B-5mqcB:
undetectable
4a97C-5mqcB:
undetectable		 4a97B-5mqcB:
22.68
4a97C-5mqcB:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nf2 MINOR FIMBRIUM
SUBUNIT MFA1

(Porphyromonas
gingivalis) 		no annotation 5 VAL A 547
ILE A 489
ILE A 252
TYR A 462
VAL A 389
 None
 1.01A 4a97B-5nf2A:
undetectable
4a97C-5nf2A:
undetectable		 4a97B-5nf2A:
15.77
4a97C-5nf2A:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nl7 CALPONIN HOMOLOGY
DOMAIN PROTEIN
PUTATIVE

(Entamoeba
histolytica) 		no annotation 5 PHE A  40
VAL A 108
ILE A 112
GLU A  45
ILE A  58
 None
 1.19A 4a97B-5nl7A:
undetectable
4a97C-5nl7A:
undetectable		 4a97B-5nl7A:
13.99
4a97C-5nl7A:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o64 REACTION CENTER
PROTEIN H CHAIN

(Blastochloris
viridis) 		PF03967
(PRCH)
PF05239
(PRC) 		5 GLU H 234
ILE H 230
GLU H 235
HIS H  72
VAL H  76
 None
 1.20A 4a97B-5o64H:
undetectable
4a97C-5o64H:
undetectable		 4a97B-5o64H:
20.75
4a97C-5o64H:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oki SISTER CHROMATID
COHESION PROTEIN
DCC1

(Saccharomyces
cerevisiae) 		no annotation 5 VAL C 234
ILE C 231
ILE C 254
HIS C 190
VAL C 215
 None
 1.02A 4a97B-5okiC:
undetectable
4a97C-5okiC:
undetectable		 4a97B-5okiC:
13.42
4a97C-5okiC:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wox UNCHARACTERIZED
PROTEIN

(Mycolicibacterium
smegmatis) 		no annotation 5 VAL A 103
ILE A  12
GLU A  81
ILE A 131
VAL A 143
 None
 1.09A 4a97B-5woxA:
undetectable
4a97C-5woxA:
undetectable		 4a97B-5woxA:
13.03
4a97C-5woxA:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xhw PUTATIVE
6-DEOXY-D-MANNOHEPTO
SE PATHWAY PROTEIN

(Yersinia
pseudotuberculosis) 		no annotation 5 ILE A   6
ASN A 106
ILE A 154
TYR A 170
VAL A   4
 None
 1.20A 4a97B-5xhwA:
undetectable
4a97C-5xhwA:
undetectable		 4a97B-5xhwA:
12.34
4a97C-5xhwA:
12.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xsq NUCLEOPROTEIN

(Marburg
marburgvirus) 		PF05505
(Ebola_NP) 		5 PHE A  83
VAL A  86
ILE A  75
GLU A  46
ILE A 113
 None
 1.28A 4a97B-5xsqA:
undetectable
4a97C-5xsqA:
undetectable		 4a97B-5xsqA:
21.14
4a97C-5xsqA:
21.14