SIMILAR PATTERNS OF AMINO ACIDS FOR 4A84_A_DXCA1161_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e3h GUANOSINE
PENTAPHOSPHATE
SYNTHETASE

(Streptomyces
antibioticus) 		PF00013
(KH_1)
PF01138
(RNase_PH)
PF03726
(PNPase) 		5 PHE A 110
PRO A 151
PRO A 258
ALA A  53
SER A  54
 None
None
None
None
SO4  A 901 (-4.1A)
 1.38A 4a84A-1e3hA:
1.2		 4a84A-1e3hA:
12.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ee8 MUTM (FPG) PROTEIN

(Thermus
thermophilus) 		PF01149
(Fapy_DNA_glyco)
PF06827
(zf-FPG_IleRS)
PF06831
(H2TH) 		5 PHE A 135
PHE A 132
PRO A 125
LEU A   3
ALA A 193
 None
 1.49A 4a84A-1ee8A:
1.1		 4a84A-1ee8A:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ehk BA3-TYPE
CYTOCHROME-C OXIDASE

(Thermus
thermophilus) 		PF00115
(COX1) 		5 PHE A 385
PRO A 382
LEU A 439
TYR A  46
GLN A  42
 HAS  A 801 ( 3.7A)
None
None
HEM  A 800 (-4.5A)
HEM  A 800 (-4.4A)
 1.47A 4a84A-1ehkA:
undetectable		 4a84A-1ehkA:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fvf SEC1

(Doryteuthis
pealeii) 		PF00995
(Sec1) 		5 PRO A 502
TYR A 153
VAL A 544
ALA A 199
SER A 197
 None
 1.16A 4a84A-1fvfA:
0.3		 4a84A-1fvfA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mi1 NEUROBEACHIN

(Homo sapiens) 		PF02138
(Beach)
PF14844
(PH_BEACH) 		5 PHE A2388
PHE A2385
PRO A2384
VAL A2172
ALA A2152
 None
 1.32A 4a84A-1mi1A:
0.0		 4a84A-1mi1A:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ndf CARNITINE
ACETYLTRANSFERASE

(Mus musculus) 		PF00755
(Carn_acyltransf) 		5 PHE A 421
PRO A 422
PRO A 580
GLN A 434
ALA A 436
 None
 1.48A 4a84A-1ndfA:
0.0		 4a84A-1ndfA:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sbp SULFATE-BINDING
PROTEIN

(Salmonella
enterica) 		PF13531
(SBP_bac_11) 		5 PHE A 275
PRO A 276
PRO A 213
VAL A 188
ALA A 196
 None
 1.26A 4a84A-1sbpA:
0.0		 4a84A-1sbpA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ua4 ADP-DEPENDENT
GLUCOKINASE

(Pyrococcus
furiosus) 		PF04587
(ADP_PFK_GK) 		5 LEU A 381
TYR A 125
VAL A  19
ALA A 446
SER A 444
 None
 1.47A 4a84A-1ua4A:
0.4		 4a84A-1ua4A:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1umg 385AA LONG CONSERVED
HYPOTHETICAL PROTEIN

(Sulfurisphaera
tokodaii) 		PF01950
(FBPase_3) 		5 PHE A 255
PRO A 142
LEU A 143
VAL A 217
ALA A 131
 None
 1.47A 4a84A-1umgA:
2.1		 4a84A-1umgA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vrb PUTATIVE ASPARAGINYL
HYDROXYLASE

(Bacillus
subtilis) 		PF08007
(Cupin_4) 		5 PHE A  21
PRO A  30
LEU A 164
VAL A 208
ALA A  33
 None
 1.26A 4a84A-1vrbA:
undetectable		 4a84A-1vrbA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wql IRON-SULFUR PROTEIN
LARGE SUBUNIT OF
CUMENE DIOXYGENASE

(Pseudomonas
fluorescens) 		PF00355
(Rieske)
PF00848
(Ring_hydroxyl_A) 		5 PHE A 425
PRO A 426
PHE A 266
LEU A 188
TYR A 169
 None
 1.47A 4a84A-1wqlA:
3.3		 4a84A-1wqlA:
15.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z2i MALATE DEHYDROGENASE

(Agrobacterium
tumefaciens) 		PF02615
(Ldh_2) 		5 PHE A 350
TYR A 357
VAL A 335
ALA A 342
SER A 344
 None
 1.38A 4a84A-1z2iA:
undetectable		 4a84A-1z2iA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z6u NP95-LIKE RING
FINGER PROTEIN
ISOFORM B

(Homo sapiens) 		PF00097
(zf-C3HC4) 		5 PHE A 795
PHE A 794
LEU A 717
SER A 730
MET A 732
 None
 1.37A 4a84A-1z6uA:
undetectable		 4a84A-1z6uA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2am4 ALPHA-1,3-MANNOSYL-G
LYCOPROTEIN
2-BETA-N-ACETYLGLUCO
SAMINYLTRANSFERASE

(Oryctolagus
cuniculus) 		PF03071
(GNT-I) 		5 PHE A 316
LEU A 128
TYR A 157
VAL A 161
ALA A 114
 None
None
None
GOL  A 450 (-4.7A)
U2F  A 449 (-4.8A)
 1.44A 4a84A-2am4A:
undetectable		 4a84A-2am4A:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bru NAD(P)
TRANSHYDROGENASE
SUBUNIT BETA

(Escherichia
coli) 		PF02233
(PNTB) 		5 PHE C 163
PHE C 164
PRO C 161
GLN C 123
ALA C 121
 None
 1.09A 4a84A-2bruC:
undetectable		 4a84A-2bruC:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d4e 5-CARBOXYMETHYL-2-HY
DROXYMUCONATE
SEMIALDEHYDE
DEHYDROGENASE

(Thermus
thermophilus) 		PF00171
(Aldedh) 		5 PHE A 475
PRO A 185
LEU A 187
VAL A 193
SER A 179
 None
 1.33A 4a84A-2d4eA:
undetectable		 4a84A-2d4eA:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ip4 PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE

(Thermus
thermophilus) 		PF01071
(GARS_A)
PF02843
(GARS_C)
PF02844
(GARS_N) 		5 PRO A 348
LEU A 327
TYR A 403
VAL A 325
ALA A 391
 None
 1.44A 4a84A-2ip4A:
undetectable		 4a84A-2ip4A:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2isa CATALASE

(Aliivibrio
salmonicida) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		5 PRO A 275
PHE A 276
PRO A 326
LEU A 401
ALA A 269
 None
 1.34A 4a84A-2isaA:
1.3		 4a84A-2isaA:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iwa GLUTAMINE
CYCLOTRANSFERASE

(Carica papaya) 		PF05096
(Glu_cyclase_2) 		5 PHE A 111
LEU A  48
VAL A  71
SER A  67
MET A  84
 NAG  A 503 (-4.7A)
None
None
None
None
 1.48A 4a84A-2iwaA:
undetectable		 4a84A-2iwaA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jgp TYROCIDINE
SYNTHETASE 3

(Brevibacillus
brevis) 		PF00550
(PP-binding)
PF00668
(Condensation) 		5 PHE A 392
LEU A 336
TYR A 339
VAL A 354
ALA A 344
 None
 1.43A 4a84A-2jgpA:
2.5		 4a84A-2jgpA:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jis CYSTEINE SULFINIC
ACID DECARBOXYLASE

(Homo sapiens) 		PF00282
(Pyridoxal_deC) 		5 PHE A 465
PHE A 416
PRO A 418
GLN A 491
MET A 445
 None
 1.29A 4a84A-2jisA:
undetectable		 4a84A-2jisA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rhq PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN

(Staphylococcus
haemolyticus) 		PF01588
(tRNA_bind)
PF03147
(FDX-ACB)
PF03483
(B3_4)
PF03484
(B5) 		5 PHE B 143
PRO B 144
LEU B 387
TYR B 262
ALA B 243
 None
 1.41A 4a84A-2rhqB:
3.9		 4a84A-2rhqB:
11.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vii PSP OPERON
TRANSCRIPTIONAL
ACTIVATOR

(Escherichia
coli) 		PF00158
(Sigma54_activat) 		5 PHE A  60
LEU A 176
VAL A  18
GLN A  21
ALA A  26
 None
 1.48A 4a84A-2viiA:
undetectable		 4a84A-2viiA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ypq PHOSPHO-2-DEHYDRO-3-
DEOXYHEPTONATE
ALDOLASE AROG

(Mycobacterium
tuberculosis) 		PF01474
(DAHP_synth_2) 		5 PRO A 302
LEU A  71
VAL A 122
ALA A 245
SER A 246
 None
 1.26A 4a84A-2ypqA:
undetectable		 4a84A-2ypqA:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zxx DNA REPLICATION
FACTOR CDT1

(Mus musculus) 		PF08839
(CDT1) 		5 PHE C 347
LEU C 314
VAL C 207
GLN C 204
ALA C 188
 None
 1.50A 4a84A-2zxxC:
undetectable		 4a84A-2zxxC:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cb0 4-HYDROXYPHENYLACETA
TE 3-MONOOXYGENASE

(Brucella
melitensis) 		PF01613
(Flavin_Reduct) 		5 PHE A 107
LEU A 161
TYR A 168
ALA A  94
SER A  96
 None
None
None
None
FMN  A 200 (-4.0A)
 1.36A 4a84A-3cb0A:
undetectable		 4a84A-3cb0A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ebc TYPE-2 RESTRICTION
ENZYME HINCII

(Haemophilus
influenzae) 		PF09226
(Endonuc-HincII) 		5 PHE A 210
PRO A 140
LEU A 126
VAL A  41
SER A 186
 None
 1.48A 4a84A-3ebcA:
undetectable		 4a84A-3ebcA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hsy GLUTAMATE RECEPTOR 2

(Rattus
norvegicus) 		PF01094
(ANF_receptor) 		5 PRO A  13
PHE A  70
PRO A  93
LEU A 278
TYR A 274
 None
 1.20A 4a84A-3hsyA:
undetectable		 4a84A-3hsyA:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hva PROTEIN FIMX

(Pseudomonas
aeruginosa) 		PF00990
(GGDEF) 		5 PHE A 281
PHE A 345
GLN A 427
ALA A 410
MET A 407
 None
 1.39A 4a84A-3hvaA:
undetectable		 4a84A-3hvaA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jrk TAGATOSE
1,6-DIPHOSPHATE
ALDOLASE 2

(Streptococcus
pyogenes) 		PF01791
(DeoC) 		5 PHE A 122
PRO A  67
LEU A  71
ALA A 109
SER A 108
 None
 1.31A 4a84A-3jrkA:
undetectable		 4a84A-3jrkA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kao TAGATOSE
1,6-DIPHOSPHATE
ALDOLASE

(Staphylococcus
aureus) 		PF01791
(DeoC) 		5 PHE A 126
PRO A  71
LEU A  75
ALA A 113
SER A 112
 None
 1.36A 4a84A-3kaoA:
undetectable		 4a84A-3kaoA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nap CAPSID PROTEIN
CAPSID PROTEIN

(Triatoma virus;
Triatoma virus) 		PF08762
(CRPV_capsid)
PF00073
(Rhv) 		5 PRO B 200
PHE A 112
LEU A 231
ALA A 188
SER A 187
 None
 1.16A 4a84A-3napB:
undetectable		 4a84A-3napB:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p5p TAXADIENE SYNTHASE

(Taxus
brevifolia) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		5 PHE A 834
TYR A 856
VAL A 855
ALA A 589
SER A 588
 A3C  A 912 ( 3.8A)
None
None
None
None
 1.21A 4a84A-3p5pA:
undetectable		 4a84A-3p5pA:
12.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tr6 O-METHYLTRANSFERASE

(Coxiella
burnetii) 		PF01596
(Methyltransf_3) 		5 PRO A  24
LEU A  83
VAL A  57
ALA A  50
SER A  75
 None
None
None
None
SAH  A 224 (-2.8A)
 1.22A 4a84A-3tr6A:
undetectable		 4a84A-3tr6A:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zty MANNOSYL-3-PHOSPHOGL
YCERATE PHOSPHATASE

(Thermus
thermophilus) 		PF08282
(Hydrolase_3) 		5 PRO A  34
PRO A  54
LEU A  65
VAL A  71
ALA A 194
 None
 1.08A 4a84A-3ztyA:
undetectable		 4a84A-3ztyA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zu0 NAD NUCLEOTIDASE

(Haemophilus
influenzae) 		PF00149
(Metallophos)
PF02872
(5_nucleotid_C) 		5 PRO A 399
PHE A 490
PRO A 491
LEU A 474
VAL A 514
 None
 1.30A 4a84A-3zu0A:
undetectable		 4a84A-3zu0A:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c79 SMOOTHENED

(Danio rerio) 		PF01392
(Fz) 		5 PRO A 142
LEU A 145
TYR A 108
VAL A 107
SER A  74
 None
 1.35A 4a84A-4c79A:
undetectable		 4a84A-4c79A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4edn BETA-PARVIN

(Homo sapiens) 		PF00307
(CH) 		5 PRO A 309
LEU A 268
VAL A 275
GLN A 281
ALA A 283
 None
 1.20A 4a84A-4ednA:
undetectable		 4a84A-4ednA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jla ADENYLATE KINASE

(Aquifex
aeolicus) 		PF00406
(ADK) 		5 PHE A  72
PHE A  83
PRO A  84
LEU A 172
TYR A 175
 None
 1.42A 4a84A-4jlaA:
undetectable		 4a84A-4jlaA:
27.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k1x NADPH:FERREDOXIN
REDUCTASE

(Rhodobacter
capsulatus) 		PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6) 		5 PHE A  34
LEU A 104
VAL A  50
ALA A  69
SER A  70
 None
 0.82A 4a84A-4k1xA:
undetectable		 4a84A-4k1xA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kvg AMYLOID BETA A4
PRECURSOR
PROTEIN-BINDING
FAMILY B MEMBER
1-INTERACTING
PROTEIN

(Mus musculus) 		PF00169
(PH)
PF00788
(RA) 		5 PHE B 306
PRO B 273
PRO B 314
LEU B 316
ALA B 268
 None
 1.50A 4a84A-4kvgB:
undetectable		 4a84A-4kvgB:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p3i P DOMAIN OF VP1

(Norwalk virus) 		PF00915
(Calici_coat)
PF08435
(Calici_coat_C) 		5 PRO A 362
PHE A 325
PRO A 326
LEU A 383
VAL A 386
 None
 1.46A 4a84A-4p3iA:
undetectable		 4a84A-4p3iA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4whm UDP-GLUCOSE:ANTHOCYA
NIDIN
3-O-GLUCOSYLTRANSFER
ASE

(Clitoria
ternatea) 		PF00201
(UDPGT) 		5 PRO A  20
VAL A 274
ALA A 346
SER A 348
MET A 350
 None
UDP  A1001 ( 4.3A)
GOL  A1002 ( 3.4A)
UDP  A1001 (-2.5A)
None
 1.45A 4a84A-4whmA:
undetectable		 4a84A-4whmA:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xwu INOSINE-5'-MONOPHOSP
HATE
DEHYDROGENASE,INOSIN
E-5'-MONOPHOSPHATE
DEHYDROGENASE

(Eremothecium
gossypii) 		PF00478
(IMPDH) 		5 PHE A  71
PRO A  70
LEU A 483
VAL A  55
GLN A 472
 None
 1.31A 4a84A-4xwuA:
undetectable		 4a84A-4xwuA:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y1b ANTE

(Streptomyces
sp. NRRL 2288) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 PHE A 281
PHE A 285
PRO A 295
VAL A 222
ALA A 231
 None
 1.25A 4a84A-4y1bA:
undetectable		 4a84A-4y1bA:
15.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4z3l MAJOR POLLEN
ALLERGEN BET V 1-A

(Betula pendula) 		PF00407
(Bet_v_1) 		9 PHE A  58
PHE A  62
PRO A  63
PHE A  64
LEU A  95
TYR A 120
VAL A 128
SER A 136
MET A 139
 None
None
None
SO4  A 202 (-4.8A)
None
None
None
None
None
 0.91A 4a84A-4z3lA:
27.8		 4a84A-4z3lA:
96.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4z3l MAJOR POLLEN
ALLERGEN BET V 1-A

(Betula pendula) 		PF00407
(Bet_v_1) 		9 PHE A  58
PRO A  63
PHE A  64
LEU A  95
TYR A 120
VAL A 128
ALA A 135
SER A 136
MET A 139
 None
None
SO4  A 202 (-4.8A)
None
None
None
None
None
None
 0.84A 4a84A-4z3lA:
27.8		 4a84A-4z3lA:
96.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cio PYRROLOQUINOLINE
QUINONE BIOSYNTHESIS
PROTEIN PQQF

(Serratia sp.
FS14) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C) 		5 PHE A 411
LEU A 391
VAL A 307
ALA A 316
SER A 313
 None
 1.34A 4a84A-5cioA:
2.7		 4a84A-5cioA:
9.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cj5 ALPHA-1,4-GLUCAN:MAL
TOSE-1-PHOSPHATE
MALTOSYLTRANSFERASE

(Mycolicibacterium
thermoresistibile) 		PF00128
(Alpha-amylase)
PF11896
(DUF3416) 		5 PHE A 322
LEU A 271
VAL A 269
ALA A 327
SER A 328
 None
 1.23A 4a84A-5cj5A:
undetectable		 4a84A-5cj5A:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d1r RV1816
TRANSCRIPTIONAL
REGULATOR

(Mycobacterium
tuberculosis) 		PF00440
(TetR_N) 		5 PRO A 180
PHE A 179
LEU A 192
VAL A 228
ALA A 148
 None
None
56S  A 305 ( 4.3A)
None
None
 1.19A 4a84A-5d1rA:
undetectable		 4a84A-5d1rA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d86 PROBABLE SIDEROPHORE
BIOSYNTHESIS PROTEIN
SBNA

(Staphylococcus
aureus) 		PF00291
(PALP) 		5 PRO A 235
PHE A 152
LEU A  78
SER A 189
MET A 191
 None
None
None
PLP  A1001 (-2.7A)
None
 1.44A 4a84A-5d86A:
undetectable		 4a84A-5d86A:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d8w ENDOGLUCANASE

(Ganoderma
lucidum) 		PF00150
(Cellulase) 		5 PHE A  34
PRO A  50
PRO A  78
VAL A 307
ALA A 311
 None
 1.40A 4a84A-5d8wA:
undetectable		 4a84A-5d8wA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e6t CAPSID

(Norwalk virus) 		PF00915
(Calici_coat)
PF08435
(Calici_coat_C) 		5 PRO A 349
PHE A 316
PRO A 317
LEU A 369
SER A 320
 None
 1.35A 4a84A-5e6tA:
undetectable		 4a84A-5e6tA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e8y TGF-BETA RECEPTOR
TYPE-2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 PRO A 498
PHE A 474
LEU A 430
ALA A 451
SER A 449
 None
 1.37A 4a84A-5e8yA:
undetectable		 4a84A-5e8yA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f15 4-AMINO-4-DEOXY-L-AR
ABINOSE (L-ARA4N)
TRANSFERASE

(Cupriavidus
metallidurans) 		PF13231
(PMT_2) 		5 PHE A 293
PRO A 295
LEU A 364
VAL A 432
ALA A 440
 None
 1.44A 4a84A-5f15A:
undetectable		 4a84A-5f15A:
12.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g0q BETA-GLUCURONIDASE

(Acidobacterium
capsulatum) 		PF03662
(Glyco_hydro_79n) 		5 PHE A 212
LEU A 165
TYR A 137
VAL A 156
ALA A 149
 None
 1.37A 4a84A-5g0qA:
undetectable		 4a84A-5g0qA:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g3f THERMUS THERMOPHILUS
MULTICOPPER OXIDASE

(Thermus
thermophilus) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 PHE A 147
PRO A 136
LEU A  94
TYR A 134
ALA A 227
 None
 1.37A 4a84A-5g3fA:
undetectable		 4a84A-5g3fA:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hgq LYSINE--TRNA LIGASE

(Loa loa) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon) 		5 PHE A  40
PRO A 120
LEU A  53
VAL A  51
SER A  46
 None
 1.47A 4a84A-5hgqA:
undetectable		 4a84A-5hgqA:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hqn SPHINGOMYELIN
PHOSPHODIESTERASE

(Mus musculus) 		PF00149
(Metallophos) 		5 PHE A 478
PHE A 453
PRO A 426
TYR A 438
ALA A 475
 None
 1.23A 4a84A-5hqnA:
undetectable		 4a84A-5hqnA:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iuw ALDEHYDE
DEHYDROGENASE FAMILY
PROTEIN

(Pseudomonas
syringae group
genomosp. 3) 		no annotation 5 PRO A 166
TYR A 487
VAL A 161
ALA A 174
MET A 172
 NAD  A 700 (-4.2A)
None
None
None
IAC  A 701 ( 3.8A)
 1.48A 4a84A-5iuwA:
undetectable		 4a84A-5iuwA:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5keu TAURINE DIOXYGENASE

(Paraburkholderia
xenovorans) 		PF02668
(TauD) 		5 PHE A  53
PHE A  54
LEU A  34
GLN A  41
ALA A  45
 None
 1.43A 4a84A-5keuA:
undetectable		 4a84A-5keuA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kzy SMOOTHENED

(Xenopus laevis) 		PF01392
(Fz) 		5 PRO A 137
LEU A 140
TYR A 103
VAL A 102
SER A  69
 CY8  A1201 ( 4.9A)
None
None
None
None
 1.40A 4a84A-5kzyA:
undetectable		 4a84A-5kzyA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l16 PUTATIVE
SELENOPHOSPHATE
SYNTHETASE

(Leishmania
major) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		5 PRO A 244
LEU A 142
VAL A 211
SER A 188
MET A 184
 None
 1.40A 4a84A-5l16A:
undetectable		 4a84A-5l16A:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l7z MATERNAL PROTEIN
EXUPERANTIA

(Drosophila
melanogaster) 		no annotation 5 PHE A  63
PHE A 115
VAL A  83
ALA A 261
SER A 262
 None
 1.46A 4a84A-5l7zA:
undetectable		 4a84A-5l7zA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l80 MATERNAL PROTEIN
EXUPERANTIA,MATERNAL
PROTEIN EXUPERANTIA

(Drosophila
melanogaster) 		no annotation 5 PHE A  63
PHE A 115
VAL A  83
ALA A 208
SER A 209
 None
 1.43A 4a84A-5l80A:
undetectable		 4a84A-5l80A:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n6r BREAKPOINT CLUSTER
REGION PROTEIN

(Homo sapiens) 		no annotation 5 PRO A 523
LEU A 527
VAL A 537
GLN A 614
SER A 619
 None
 1.19A 4a84A-5n6rA:
undetectable		 4a84A-5n6rA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tc3 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Eremothecium
gossypii) 		PF00478
(IMPDH)
PF00571
(CBS) 		5 PHE A  71
PRO A  70
LEU A 483
VAL A  55
GLN A 472
 None
 1.29A 4a84A-5tc3A:
undetectable		 4a84A-5tc3A:
14.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vba LYSOZYME, ESX-1
SECRETION-ASSOCIATED
PROTEIN ESPG1
CHIMERA

(Mycobacterium
kansasii;
Escherichia
virus T4) 		PF00959
(Phage_lysozyme)
PF14011
(ESX-1_EspG) 		5 PRO A  39
PHE A  38
LEU A  29
VAL A  21
ALA A 123
 None
 1.24A 4a84A-5vbaA:
undetectable		 4a84A-5vbaA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vj1 MDCA
MDCC

(Pseudomonas
aeruginosa;
Pseudomonas
protegens) 		PF16957
(Mal_decarbox_Al)
PF06857
(ACP) 		5 PRO A 430
PHE A 424
PRO C  82
LEU C  58
ALA A 488
 None
 1.49A 4a84A-5vj1A:
undetectable		 4a84A-5vj1A:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yhj CYTOCHROME P450

(Exiguobacterium
sp. AT1b) 		no annotation 5 PHE A  79
PRO A  71
LEU A  42
VAL A  46
ALA A 289
 None
None
None
None
HEM  A 501 ( 4.1A)
 1.32A 4a84A-5yhjA:
undetectable		 4a84A-5yhjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5za2 BETA-LACTAMASE

(Escherichia
coli) 		no annotation 5 PHE A 300
PRO A 303
PHE A 258
TYR A 312
ALA A 305
 None
 1.33A 4a84A-5za2A:
undetectable		 4a84A-5za2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cnz CHORISMATE MUTASE

(Burkholderia
thailandensis) 		no annotation 5 PHE A  97
LEU A 137
VAL A  56
GLN A 109
ALA A 104
 None
 1.29A 4a84A-6cnzA:
undetectable		 4a84A-6cnzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cp7 ATP SYNTHASE SUBUNIT
A

(Saccharomyces
cerevisiae) 		no annotation 5 PHE X  90
PHE X  93
LEU X 101
ALA X  64
SER X  61
 None
 1.39A 4a84A-6cp7X:
undetectable		 4a84A-6cp7X:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d35 SMOOTHENED,SOLUBLE
CYTOCHROME
B562,SMOOTHENED

(Escherichia
coli;
Xenopus laevis) 		no annotation 5 PRO A 137
LEU A 140
TYR A 103
VAL A 102
SER A  69
 CLR  A1201 ( 4.8A)
None
None
None
None
 1.48A 4a84A-6d35A:
undetectable		 4a84A-6d35A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dex SUPPRESSOR OF
HYDROXYUREA
SENSITIVITY PROTEIN
2

(Eremothecium
gossypii) 		no annotation 5 PHE B 160
LEU B  22
VAL B  27
ALA B  42
SER B  44
 None
 1.34A 4a84A-6dexB:
undetectable		 4a84A-6dexB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ft1 FLAVODOXIN

(Bacillus cereus) 		no annotation 5 PRO A  42
PHE A  72
LEU A 110
VAL A  88
ALA A   9
 None
 1.42A 4a84A-6ft1A:
undetectable		 4a84A-6ft1A:
undetectable