SIMILAR PATTERNS OF AMINO ACIDS FOR 4A83_A_DXCA1160_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e5f METHIONINE
GAMMA-LYASE

(Trichomonas
vaginalis) 		PF01053
(Cys_Met_Meta_PP) 		5 PHE A 292
PRO A 156
ILE A 192
SER A 268
MET A 272
 None
 1.17A 4a83A-1e5fA:
1.0		 4a83A-1e5fA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gey HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE

(Escherichia
coli) 		PF00155
(Aminotran_1_2) 		5 PRO A 165
PHE A 168
ILE A 208
ALA A 194
SER A 195
 None
 1.29A 4a83A-1geyA:
0.6		 4a83A-1geyA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gyt CYTOSOL
AMINOPEPTIDASE

(Escherichia
coli) 		PF00883
(Peptidase_M17)
PF02789
(Peptidase_M17_N) 		5 PHE A 159
PHE A 111
LEU A  35
ILE A  73
ALA A 108
 None
 1.35A 4a83A-1gytA:
0.0		 4a83A-1gytA:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jr7 HYPOTHETICAL 37.4
KDA PROTEIN IN
ILEY-GABD INTERGENIC
REGION

(Escherichia
coli) 		PF08943
(CsiD) 		5 PHE A  37
LEU A  87
ILE A 122
TYR A 172
ALA A 115
 None
 1.42A 4a83A-1jr7A:
undetectable		 4a83A-1jr7A:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k32 TRICORN PROTEASE

(Thermoplasma
acidophilum) 		PF03572
(Peptidase_S41)
PF07676
(PD40)
PF14684
(Tricorn_C1)
PF14685
(Tricorn_PDZ) 		5 PRO A 802
LEU A 825
ILE A 821
TYR A 822
ALA A 779
 None
 1.39A 4a83A-1k32A:
0.0		 4a83A-1k32A:
9.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l5a AMIDE SYNTHASE

(Vibrio cholerae) 		PF00668
(Condensation) 		5 PRO A 254
PRO A 280
LEU A 279
ILE A 316
ALA A 191
 None
 1.37A 4a83A-1l5aA:
2.1		 4a83A-1l5aA:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lln ANTIVIRAL PROTEIN 3

(Phytolacca
americana) 		PF00161
(RIP) 		5 LEU A  70
ILE A  63
GLN A 168
ALA A 173
SER A 174
 None
 1.42A 4a83A-1llnA:
0.7		 4a83A-1llnA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1obp ODORANT-BINDING
PROTEIN

(Bos taurus) 		PF00061
(Lipocalin) 		5 PHE A  40
PHE A  56
LEU A  10
ILE A  91
ALA A  71
 UNX  A 163 (-4.4A)
UNX  A 194 (-4.1A)
None
None
UNX  A 170 ( 4.0A)
 1.36A 4a83A-1obpA:
2.3		 4a83A-1obpA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1px8 BETA-XYLOSIDASE

(Thermoanaerobacterium
saccharolyticum) 		PF01229
(Glyco_hydro_39) 		5 PHE A 354
PHE A 351
PHE A 353
LEU A 414
ALA A 295
 None
 1.33A 4a83A-1px8A:
0.9		 4a83A-1px8A:
15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pzv PROBABLE
UBIQUITIN-CONJUGATIN
G ENZYME E2-19 KDA

(Caenorhabditis
elegans) 		PF00179
(UQ_con) 		5 PRO A 134
LEU A 126
ILE A  76
GLN A 143
ALA A 139
 None
 1.40A 4a83A-1pzvA:
undetectable		 4a83A-1pzvA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qyi HYPOTHETICAL PROTEIN

(Staphylococcus
aureus) 		PF13242
(Hydrolase_like) 		5 PHE A 167
LEU A  30
ILE A  92
GLN A 116
MET A 105
 None
 1.44A 4a83A-1qyiA:
undetectable		 4a83A-1qyiA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qyi HYPOTHETICAL PROTEIN

(Staphylococcus
aureus) 		PF13242
(Hydrolase_like) 		5 PHE A 167
LEU A  38
ILE A  92
GLN A 116
MET A 105
 None
 1.31A 4a83A-1qyiA:
undetectable		 4a83A-1qyiA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1re0 ARF
GUANINE-NUCLEOTIDE
EXCHANGE FACTOR 1

(Saccharomyces
cerevisiae) 		PF01369
(Sec7) 		5 PHE B 174
LEU B 189
ILE B 185
ALA B 207
SER B 209
 None
 1.17A 4a83A-1re0B:
undetectable		 4a83A-1re0B:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v3t LEUKOTRIENE B4
12-HYDROXYDEHYDROGEN
ASE/PROSTAGLANDIN
15-KETO REDUCTASE

(Cavia porcellus) 		PF00107
(ADH_zinc_N)
PF16884
(ADH_N_2) 		5 PRO A 252
PRO A 255
LEU A 227
ILE A 267
ALA A 241
 None
 1.11A 4a83A-1v3tA:
undetectable		 4a83A-1v3tA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vmk PURINE NUCLEOSIDE
PHOSPHORYLASE

(Thermotoga
maritima) 		PF01048
(PNP_UDP_1) 		5 PHE A  51
PHE A  93
LEU A  26
ILE A  75
ALA A  98
 None
 1.32A 4a83A-1vmkA:
undetectable		 4a83A-1vmkA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wno CHITINASE

(Aspergillus
fumigatus) 		PF00704
(Glyco_hydro_18) 		5 PHE A 105
LEU A 192
ILE A 187
TYR A 244
ALA A 179
 None
 1.33A 4a83A-1wnoA:
undetectable		 4a83A-1wnoA:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wql IRON-SULFUR PROTEIN
LARGE SUBUNIT OF
CUMENE DIOXYGENASE

(Pseudomonas
fluorescens) 		PF00355
(Rieske)
PF00848
(Ring_hydroxyl_A) 		5 PHE A 425
PRO A 426
PHE A 266
LEU A 188
TYR A 169
 None
 1.42A 4a83A-1wqlA:
3.4		 4a83A-1wqlA:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xfs CONSERVED
HYPOTHETICAL PROTEIN

(Nitrosomonas
europaea) 		PF08327
(AHSA1) 		5 PHE A  39
LEU A 160
ILE A 157
TYR A 129
ALA A 116
 None
 1.41A 4a83A-1xfsA:
12.7		 4a83A-1xfsA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z6u NP95-LIKE RING
FINGER PROTEIN
ISOFORM B

(Homo sapiens) 		PF00097
(zf-C3HC4) 		5 PHE A 795
PHE A 794
LEU A 717
SER A 730
MET A 732
 None
 1.40A 4a83A-1z6uA:
undetectable		 4a83A-1z6uA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z7l UBIQUITIN-ACTIVATING
ENZYME E1 1

(Mus musculus) 		PF10585
(UBA_e1_thiolCys) 		5 PRO A 638
ILE A 875
GLN A 646
ALA A 648
SER A 866
 None
None
TBR  A 999 (-3.1A)
None
None
 1.13A 4a83A-1z7lA:
undetectable		 4a83A-1z7lA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zyp ALKYL HYDROPEROXIDE
REDUCTASE SUBUNIT F

(Salmonella
enterica) 		PF13192
(Thioredoxin_3) 		5 PRO A  63
PRO A  82
LEU A  90
ILE A  43
ALA A  25
 None
 1.35A 4a83A-1zypA:
undetectable		 4a83A-1zypA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c1c CARBOXYPEPTIDASE B

(Helicoverpa zea) 		PF00246
(Peptidase_M14) 		5 PRO A 109
LEU A  22
ILE A  83
TYR A  21
GLN A  13
 None
 1.41A 4a83A-2c1cA:
undetectable		 4a83A-2c1cA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i99 MU-CRYSTALLIN
HOMOLOG

(Homo sapiens) 		PF02423
(OCD_Mu_crystall) 		5 LEU A 139
ILE A 202
GLN A 158
ALA A 122
SER A 124
 None
 1.35A 4a83A-2i99A:
undetectable		 4a83A-2i99A:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i9c HYPOTHETICAL PROTEIN
RPA1889

(Rhodopseudomonas
palustris) 		PF09450
(DUF2019) 		5 PHE A  66
LEU A  17
ILE A  47
GLN A  12
ALA A  61
 None
 1.34A 4a83A-2i9cA:
undetectable		 4a83A-2i9cA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ibd POSSIBLE
TRANSCRIPTIONAL
REGULATOR

(Rhodococcus
jostii) 		PF00440
(TetR_N) 		5 PHE A 164
PHE A 162
LEU A 138
TYR A  77
ALA A 169
 None
 1.25A 4a83A-2ibdA:
undetectable		 4a83A-2ibdA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iv2 FORMATE
DEHYDROGENASE H

(Escherichia
coli) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		5 PHE X 462
PHE X 455
GLN X 335
ALA X 341
MET X 344
 None
None
2MD  X 801 (-3.2A)
None
None
 1.39A 4a83A-2iv2X:
undetectable		 4a83A-2iv2X:
12.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k7n PEPTIDYL-PROLYL
CIS-TRANS
ISOMERASE-LIKE 1

(Homo sapiens) 		PF00160
(Pro_isomerase) 		5 PRO A 197
PRO A 189
LEU A  90
ILE A 128
ALA A 117
 None
 1.35A 4a83A-2k7nA:
undetectable		 4a83A-2k7nA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ofk 3-METHYLADENINE DNA
GLYCOSYLASE I,
CONSTITUTIVE

(Salmonella
enterica) 		PF03352
(Adenine_glyco) 		5 PHE A  63
PHE A  32
LEU A  44
ILE A  86
ALA A  94
 None
 1.14A 4a83A-2ofkA:
undetectable		 4a83A-2ofkA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ozk URIDYLATE-SPECIFIC
ENDORIBONUCLEASE

(Severe acute
respiratory
syndrome-related
coronavirus) 		PF06471
(NSP11) 		5 PRO A 157
LEU A 122
ILE A  85
ALA A 160
SER A 161
 None
 1.43A 4a83A-2ozkA:
undetectable		 4a83A-2ozkA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qe8 UNCHARACTERIZED
PROTEIN

(Trichormus
variabilis) 		PF03022
(MRJP) 		5 PHE A 305
LEU A 173
ILE A 175
ALA A 269
SER A 268
 None
 1.25A 4a83A-2qe8A:
undetectable		 4a83A-2qe8A:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r9l PUTATIVE DNA
LIGASE-LIKE PROTEIN

(Mycobacterium
tuberculosis) 		no annotation 5 PHE A  64
PRO A  91
LEU A  76
ILE A  93
ALA A 107
 None
 1.12A 4a83A-2r9lA:
undetectable		 4a83A-2r9lA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r9u VARIABLE LYMPHOCYTE
RECEPTOR

(Petromyzon
marinus) 		PF11921
(DUF3439)
PF13855
(LRR_8) 		5 PRO A  48
PRO A  44
LEU A  40
ILE A  38
SER A  27
 None
 1.41A 4a83A-2r9uA:
undetectable		 4a83A-2r9uA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wzs PUTATIVE
ALPHA-1,2-MANNOSIDAS
E

(Bacteroides
thetaiotaomicron) 		PF07971
(Glyco_hydro_92) 		5 PHE A 354
PRO A 355
LEU A 681
ILE A 289
ALA A 650
 None
 1.38A 4a83A-2wzsA:
undetectable		 4a83A-2wzsA:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xry DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE

(Methanosarcina
mazei) 		PF00875
(DNA_photolyase) 		5 PRO A 392
LEU A 386
ILE A 440
ALA A 335
SER A 332
 None
 1.34A 4a83A-2xryA:
undetectable		 4a83A-2xryA:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xwu IMPORTIN13

(Homo sapiens) 		PF03810
(IBN_N)
PF08389
(Xpo1) 		5 LEU B 324
TYR B 386
GLN B 331
ALA B 335
MET B 339
 None
 1.25A 4a83A-2xwuB:
undetectable		 4a83A-2xwuB:
10.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y0o PROBABLE D-LYXOSE
KETOL-ISOMERASE

(Bacillus
subtilis) 		no annotation 5 LEU A  19
ILE A  17
TYR A  12
GLN A  28
MET A 151
 None
 1.08A 4a83A-2y0oA:
undetectable		 4a83A-2y0oA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b3j HISTONE-ARGININE
METHYLTRANSFERASE
CARM1

(Rattus
norvegicus) 		PF06325
(PrmA) 		5 PRO A 339
LEU A 470
ILE A 451
GLN A 418
ALA A 389
 None
 1.16A 4a83A-3b3jA:
undetectable		 4a83A-3b3jA:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cb0 4-HYDROXYPHENYLACETA
TE 3-MONOOXYGENASE

(Brucella
melitensis) 		PF01613
(Flavin_Reduct) 		5 PHE A 107
LEU A 161
TYR A 168
ALA A  94
SER A  96
 None
None
None
None
FMN  A 200 (-4.0A)
 1.37A 4a83A-3cb0A:
undetectable		 4a83A-3cb0A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ci6 PHOSPHOENOLPYRUVATE-
PROTEIN
PHOSPHOTRANSFERASE

(Acinetobacter
sp. ADP1) 		PF01590
(GAF) 		5 PHE A 139
LEU A 154
ILE A  44
GLN A  32
ALA A  34
 None
 1.38A 4a83A-3ci6A:
undetectable		 4a83A-3ci6A:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dui BETA-GALACTOSIDE-BIN
DING LECTIN

(Gallus gallus) 		PF00337
(Gal-bind_lectin) 		5 PRO A 102
LEU A 101
ILE A  88
GLN A  81
ALA A  84
 None
 1.30A 4a83A-3duiA:
undetectable		 4a83A-3duiA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h5l PUTATIVE
BRANCHED-CHAIN AMINO
ACID ABC TRANSPORTER

(Ruegeria
pomeroyi) 		PF13458
(Peripla_BP_6) 		5 PHE A 162
LEU A  86
ILE A  84
ALA A 342
SER A 344
 None
 1.31A 4a83A-3h5lA:
undetectable		 4a83A-3h5lA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ivu HOMOCITRATE
SYNTHASE,
MITOCHONDRIAL

(Schizosaccharomyces
pombe) 		PF00682
(HMGL-like) 		5 PHE A  52
LEU A  65
ILE A 251
GLN A  60
ALA A 297
 None
 1.35A 4a83A-3ivuA:
undetectable		 4a83A-3ivuA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jrk TAGATOSE
1,6-DIPHOSPHATE
ALDOLASE 2

(Streptococcus
pyogenes) 		PF01791
(DeoC) 		5 PHE A 122
PRO A  67
LEU A  71
ALA A 109
SER A 108
 None
 1.38A 4a83A-3jrkA:
undetectable		 4a83A-3jrkA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kao TAGATOSE
1,6-DIPHOSPHATE
ALDOLASE

(Staphylococcus
aureus) 		PF01791
(DeoC) 		5 PHE A 126
PRO A  71
LEU A  75
ALA A 113
SER A 112
 None
 1.42A 4a83A-3kaoA:
undetectable		 4a83A-3kaoA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3le2 SERPIN-ZX

(Arabidopsis
thaliana) 		PF00079
(Serpin) 		5 PHE A 382
PHE A  33
LEU A 292
GLN A  10
ALA A  36
 None
 1.39A 4a83A-3le2A:
undetectable		 4a83A-3le2A:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ml0 PENICILLIN G
ACYLASE, BETA
SUBUNIT

(Alcaligenes
faecalis) 		PF01804
(Penicil_amidase) 		5 PHE B 166
PRO B 193
ILE B 177
GLN B 149
ALA B 153
 None
 1.16A 4a83A-3ml0B:
undetectable		 4a83A-3ml0B:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mn2 PROBABLE ARAC FAMILY
TRANSCRIPTIONAL
REGULATOR

(Rhodopseudomonas
palustris) 		PF12833
(HTH_18) 		5 PHE A 253
PHE A 256
ILE A 236
TYR A 227
GLN A 223
 None
None
PO4  A   2 (-4.3A)
None
None
 1.29A 4a83A-3mn2A:
undetectable		 4a83A-3mn2A:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nap CAPSID PROTEIN
CAPSID PROTEIN

(Triatoma virus;
Triatoma virus) 		PF08762
(CRPV_capsid)
PF00073
(Rhv) 		5 PRO B 200
PHE A 112
LEU A 231
ALA A 188
SER A 187
 None
 1.15A 4a83A-3napB:
undetectable		 4a83A-3napB:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qat MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE

(Bartonella
henselae) 		PF00698
(Acyl_transf_1) 		5 PHE A   7
PRO A   8
LEU A  55
ILE A  47
MET A  70
 None
 1.36A 4a83A-3qatA:
undetectable		 4a83A-3qatA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rko NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT M

(Escherichia
coli) 		no annotation 5 PRO M  10
LEU M 124
ILE M 128
ALA M  41
SER M  43
 None
 1.20A 4a83A-3rkoM:
undetectable		 4a83A-3rkoM:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sir CASPASE

(Drosophila
melanogaster) 		PF00656
(Peptidase_C14) 		5 LEU A  72
ILE A  71
TYR A  68
ALA A 137
SER A  95
 None
 1.43A 4a83A-3sirA:
undetectable		 4a83A-3sirA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vjj P9-1

(Rice black
streaked dwarf
virus) 		PF06043
(Reo_P9) 		5 PHE A  94
PHE A  30
LEU A 247
ILE A  73
TYR A 244
 None
 1.37A 4a83A-3vjjA:
undetectable		 4a83A-3vjjA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vxi DYP

(Bjerkandera
adusta) 		PF04261
(Dyp_perox) 		5 PHE A  71
PHE A 429
LEU A 198
ILE A  11
ALA A 435
 None
 1.20A 4a83A-3vxiA:
0.0		 4a83A-3vxiA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dz4 AGMATINASE

(Burkholderia
thailandensis) 		PF00491
(Arginase) 		5 LEU A 153
ILE A 280
TYR A 149
GLN A 147
ALA A 118
 None
 1.16A 4a83A-4dz4A:
undetectable		 4a83A-4dz4A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fd7 PUTATIVE
ARYLALKYLAMINE
N-ACETYLTRANSFERASE
7

(Aedes aegypti) 		PF00583
(Acetyltransf_1) 		5 PHE A 202
LEU A 183
ILE A 138
TYR A 147
ALA A 150
 None
 1.26A 4a83A-4fd7A:
undetectable		 4a83A-4fd7A:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hzu ENERGY-COUPLING
FACTOR TRANSPORTER
ATP-BINDING PROTEIN
ECFA 1
ENERGY-COUPLING
FACTOR TRANSPORTER
TRANSMEMBRANE
PROTEIN ECFT

(Lactobacillus
brevis;
Lactobacillus
brevis) 		PF00005
(ABC_tran)
PF02361
(CbiQ) 		5 PHE B 144
LEU T 204
ILE T 178
ALA T 212
SER T 211
 None
 1.25A 4a83A-4hzuB:
undetectable		 4a83A-4hzuB:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jla ADENYLATE KINASE

(Aquifex
aeolicus) 		PF00406
(ADK) 		5 PHE A  72
PHE A  83
PRO A  84
LEU A 172
TYR A 175
 None
 1.39A 4a83A-4jlaA:
undetectable		 4a83A-4jlaA:
26.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jso OLIGOPEPTIDE ABC
TRANSPORTER,
PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN

(Thermotoga
maritima) 		PF00496
(SBP_bac_5) 		5 PHE A 134
LEU A 139
ILE A 574
TYR A  58
ALA A 581
 None
 1.39A 4a83A-4jsoA:
undetectable		 4a83A-4jsoA:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k22 PROTEIN VISC

(Escherichia
coli) 		PF01494
(FAD_binding_3) 		5 LEU A 249
ILE A 192
GLN A 238
ALA A 265
SER A 264
 None
 1.36A 4a83A-4k22A:
undetectable		 4a83A-4k22A:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mmh HEPARINASE III
PROTEIN

(Pedobacter
heparinus) 		PF07940
(Hepar_II_III)
PF16889
(Hepar_II_III_N) 		5 PHE A 356
LEU A 333
ILE A 299
ALA A 362
SER A 363
 None
 1.39A 4a83A-4mmhA:
undetectable		 4a83A-4mmhA:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4my5 PUTATIVE AMINO ACID
AMINOTRANSFERASE

(Streptococcus
mutans) 		PF00155
(Aminotran_1_2) 		5 PHE A  42
PRO A  40
LEU A  35
ILE A 375
ALA A 320
 None
 1.30A 4a83A-4my5A:
undetectable		 4a83A-4my5A:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4okd ISOAMYLASE

(Chlamydomonas
reinhardtii) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48) 		5 PHE A 730
LEU A 861
ILE A 859
TYR A 851
SER A 816
 None
 1.18A 4a83A-4okdA:
undetectable		 4a83A-4okdA:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pcs ALPHA-L-FUCOSIDASE

(Bacteroides
thetaiotaomicron) 		PF01120
(Alpha_L_fucos) 		5 PHE A 112
LEU A 161
ILE A 131
ALA A 118
MET A 120
 None
None
None
None
IMD  A 503 (-3.1A)
 1.04A 4a83A-4pcsA:
undetectable		 4a83A-4pcsA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pet EXTRACELLULAR
SOLUTE-BINDING
PROTEIN, FAMILY 7

(Colwellia
psychrerythraea) 		PF03480
(DctP) 		5 PHE A 150
PRO A 151
PHE A 129
LEU A 337
ILE A 333
 None
 1.42A 4a83A-4petA:
undetectable		 4a83A-4petA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pz7 MRNA-CAPPING ENZYME
SUBUNIT ALPHA

(Schizosaccharomyces
pombe) 		PF01331
(mRNA_cap_enzyme)
PF03919
(mRNA_cap_C) 		5 PHE A 188
PRO A 189
PHE A 190
LEU A 123
ILE A 170
 None
 1.26A 4a83A-4pz7A:
undetectable		 4a83A-4pz7A:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wj3 ASPARTATE--TRNA(ASP/
ASN) LIGASE

(Pseudomonas
aeruginosa) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon)
PF02938
(GAD) 		5 PHE M 438
PRO M 456
PRO M 452
ILE M 506
ALA M 499
 None
 1.32A 4a83A-4wj3M:
undetectable		 4a83A-4wj3M:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wj3 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT C

(Pseudomonas
aeruginosa;
Pseudomonas
aeruginosa) 		PF01425
(Amidase)
PF02686
(Glu-tRNAGln) 		5 PHE A 349
PHE A 125
LEU C  31
ALA A 315
SER A 316
 None
 1.28A 4a83A-4wj3A:
undetectable		 4a83A-4wj3A:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xvg ALKYL HYDROPEROXIDE
REDUCTASE SUBUNIT F

(Escherichia
coli) 		PF07992
(Pyr_redox_2)
PF13192
(Thioredoxin_3) 		5 PRO A  63
PRO A  82
LEU A  90
ILE A  43
ALA A  25
 None
 1.42A 4a83A-4xvgA:
undetectable		 4a83A-4xvgA:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yzw AGAP004976-PA

(Anopheles
gambiae) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		5 LEU A 504
ILE A 520
TYR A 502
GLN A 562
SER A 566
 None
 1.27A 4a83A-4yzwA:
undetectable		 4a83A-4yzwA:
12.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4z3l MAJOR POLLEN
ALLERGEN BET V 1-A

(Betula pendula) 		PF00407
(Bet_v_1) 		10 PHE A  58
PHE A  62
PRO A  63
PHE A  64
LEU A  95
ILE A  98
TYR A 120
ALA A 135
SER A 136
MET A 139
 None
None
None
SO4  A 202 (-4.8A)
None
None
None
None
None
None
 0.85A 4a83A-4z3lA:
27.9		 4a83A-4z3lA:
97.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zwn MONOGLYCERIDE LIPASE

(Saccharomyces
cerevisiae) 		PF12146
(Hydrolase_4) 		5 PHE A 218
PRO A 169
LEU A 170
ILE A 166
ALA A 223
 None
NO3  A 401 ( 4.9A)
None
NO3  A 401 ( 4.5A)
None
 1.13A 4a83A-4zwnA:
undetectable		 4a83A-4zwnA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zzh NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-1

(Homo sapiens) 		PF02146
(SIR2) 		5 PHE A 297
PHE A 413
LEU A 350
ILE A 270
ALA A 313
 None
 1.42A 4a83A-4zzhA:
undetectable		 4a83A-4zzhA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ckm MANNAN-BINDING
LECTIN SERINE
PEPTIDASE 2

(Rattus
norvegicus) 		PF00431
(CUB)
PF07645
(EGF_CA) 		5 PRO A 238
PHE A 239
LEU A 206
ILE A 272
GLN A 230
 None
 1.39A 4a83A-5ckmA:
undetectable		 4a83A-5ckmA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d0f UNCHARACTERIZED
PROTEIN

([Candida]
glabrata) 		PF06202
(GDE_C)
PF14699
(hGDE_N)
PF14701
(hDGE_amylase)
PF14702
(hGDE_central) 		5 PRO A 406
PHE A 407
ILE A 371
GLN A 349
ALA A 348
 None
 1.38A 4a83A-5d0fA:
undetectable		 4a83A-5d0fA:
8.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d6a PREDICTED ATPASE OF
THE ABC CLASS

(Vibrio
vulnificus) 		PF09818
(ABC_ATPase) 		5 PHE A 466
LEU A 513
ILE A 509
ALA A 538
MET A 542
 None
 1.22A 4a83A-5d6aA:
undetectable		 4a83A-5d6aA:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dom 2S ALBUMIN

(Moringa
oleifera) 		PF00234
(Tryp_alpha_amyl) 		5 PHE A 157
PRO A 145
LEU A 150
GLN A 102
SER A 114
 None
 1.33A 4a83A-5domA:
undetectable		 4a83A-5domA:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e6t CAPSID

(Norwalk virus) 		PF00915
(Calici_coat)
PF08435
(Calici_coat_C) 		5 PRO A 349
PHE A 316
PRO A 317
LEU A 369
SER A 320
 None
 1.36A 4a83A-5e6tA:
undetectable		 4a83A-5e6tA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e8y TGF-BETA RECEPTOR
TYPE-2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 PRO A 498
PHE A 474
LEU A 430
ALA A 451
SER A 449
 None
 1.40A 4a83A-5e8yA:
undetectable		 4a83A-5e8yA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5elx ATP-DEPENDENT RNA
HELICASE DBP5

(Saccharomyces
cerevisiae) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		5 ILE A 424
TYR A 420
GLN A 453
SER A 438
MET A 309
 None
 1.42A 4a83A-5elxA:
undetectable		 4a83A-5elxA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g3f THERMUS THERMOPHILUS
MULTICOPPER OXIDASE

(Thermus
thermophilus) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 PHE A 147
PRO A 136
LEU A  94
TYR A 134
ALA A 227
 None
 1.39A 4a83A-5g3fA:
undetectable		 4a83A-5g3fA:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5giv CARBOXYPEPTIDASE 1

(Deinococcus
radiodurans) 		PF02074
(Peptidase_M32) 		5 LEU A 484
ILE A 476
GLN A 420
ALA A 292
SER A 291
 None
 1.38A 4a83A-5givA:
undetectable		 4a83A-5givA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hos CELLULASE

(Xanthomonas
citri) 		PF00150
(Cellulase) 		5 PHE A 125
LEU A  52
ILE A  54
GLN A  77
ALA A  73
 None
 1.33A 4a83A-5hosA:
undetectable		 4a83A-5hosA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hqn SPHINGOMYELIN
PHOSPHODIESTERASE

(Mus musculus) 		PF00149
(Metallophos) 		5 PHE A 478
PHE A 453
PRO A 426
TYR A 438
ALA A 475
 None
 1.21A 4a83A-5hqnA:
undetectable		 4a83A-5hqnA:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lcn UNCHARACTERIZED
PROTEIN

(Pyrococcus
furiosus) 		PF12146
(Hydrolase_4) 		5 PHE A 244
LEU A 257
ILE A 229
ALA A 152
MET A 150
 None
 1.32A 4a83A-5lcnA:
undetectable		 4a83A-5lcnA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5myv SRSF PROTEIN KINASE
2,SRSF PROTEIN
KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		5 PRO A 526
LEU A 527
ILE A 188
TYR A 193
MET A 584
 None
 1.23A 4a83A-5myvA:
undetectable		 4a83A-5myvA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n6u BETA-MANNOSIDASE

(Dictyoglomus
thermophilum) 		PF00703
(Glyco_hydro_2)
PF02837
(Glyco_hydro_2_N) 		5 PHE A 703
LEU A 570
ILE A 573
TYR A 569
ALA A 758
 None
 1.30A 4a83A-5n6uA:
undetectable		 4a83A-5n6uA:
11.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n6u BETA-MANNOSIDASE

(Dictyoglomus
thermophilum) 		PF00703
(Glyco_hydro_2)
PF02837
(Glyco_hydro_2_N) 		5 PHE A 722
LEU A 570
ILE A 573
TYR A 569
ALA A 758
 None
 1.38A 4a83A-5n6uA:
undetectable		 4a83A-5n6uA:
11.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5opt 40S RIBOSOMAL
PROTEIN S6

(Trypanosoma
cruzi) 		no annotation 5 PHE P  16
PHE P  42
LEU P 105
ILE P 109
GLN P  54
 None
None
None
None
A  E 168 ( 4.1A)
 1.36A 4a83A-5optP:
undetectable		 4a83A-5optP:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tqi PYRIDOXAL KINASE
PDXY

(Burkholderia
multivorans) 		PF08543
(Phos_pyr_kin) 		5 PHE A  23
PRO A  24
LEU A  28
ILE A 226
ALA A 268
 None
 1.37A 4a83A-5tqiA:
undetectable		 4a83A-5tqiA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u89 AMINO ACID
ADENYLATION DOMAIN
PROTEIN

(Geobacillus sp.
Y4.1MC1) 		PF00501
(AMP-binding)
PF00550
(PP-binding)
PF00668
(Condensation)
PF13193
(AMP-binding_C) 		5 PRO A 665
LEU A 719
ILE A 690
GLN A 699
ALA A 649
 None
 1.06A 4a83A-5u89A:
2.1		 4a83A-5u89A:
10.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uh0 MEMBRANE-BOUND LYTIC
MUREIN
TRANSGLYCOSYLASE F

(Yersinia pestis) 		PF00497
(SBP_bac_3) 		5 PHE A 232
LEU A  45
ILE A  39
ALA A 242
SER A 239
 None
 1.32A 4a83A-5uh0A:
undetectable		 4a83A-5uh0A:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uos METHYLMALONIC
ACIDURIA AND
HOMOCYSTINURIA TYPE
C PROTEIN

(Homo sapiens) 		PF16690
(MMACHC) 		5 PRO A  25
PHE A  50
LEU A  94
GLN A  10
ALA A   6
 None
 1.36A 4a83A-5uosA:
undetectable		 4a83A-5uosA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vvh OCTOPINE
CATABOLISM/UPTAKE
OPERON REGULATORY
PROTEIN OCCR

(Agrobacterium
tumefaciens) 		PF03466
(LysR_substrate) 		5 PHE A 257
PRO A 182
LEU A 185
ILE A 207
ALA A 164
 None
 1.42A 4a83A-5vvhA:
undetectable		 4a83A-5vvhA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x8r PROTEIN PLASTID PY

(Spinacia
oleracea) 		no annotation 5 PRO y  71
LEU y 136
ILE y 164
ALA y 103
SER y 101
 None
 1.16A 4a83A-5x8ry:
undetectable		 4a83A-5x8ry:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xjy ATP-BINDING CASSETTE
SUB-FAMILY A MEMBER
1

(Homo sapiens) 		PF00005
(ABC_tran)
PF12698
(ABC2_membrane_3) 		5 LEU A1404
ILE A1613
ALA A  64
SER A  63
MET A  61
 None
 1.30A 4a83A-5xjyA:
undetectable		 4a83A-5xjyA:
5.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5za2 BETA-LACTAMASE

(Escherichia
coli) 		no annotation 5 PHE A 300
PRO A 303
PHE A 258
TYR A 312
ALA A 305
 None
 1.34A 4a83A-5za2A:
undetectable		 4a83A-5za2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bhu MULTIDRUG
RESISTANCE-ASSOCIATE
D PROTEIN 1

(Bos taurus) 		no annotation 5 PRO A 712
PRO A 794
LEU A 795
ILE A 811
ALA A 781
 None
 1.23A 4a83A-6bhuA:
undetectable		 4a83A-6bhuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c8z ADP-DEPENDENT
PHOSPHOFRUCTOKINASE

(Methanosarcinales) 		no annotation 5 PRO A 137
PRO A 156
LEU A 165
ILE A 231
ALA A  30
 None
 1.37A 4a83A-6c8zA:
undetectable		 4a83A-6c8zA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cp7 ATP SYNTHASE SUBUNIT
A

(Saccharomyces
cerevisiae) 		no annotation 5 PHE X  90
PHE X  93
LEU X 101
ALA X  64
SER X  61
 None
 1.39A 4a83A-6cp7X:
undetectable		 4a83A-6cp7X:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ekv TOXIN COMPLEX
COMPONENT ORF-X2

(Clostridium
botulinum) 		no annotation 5 PHE A 414
PRO A 358
LEU A 344
ILE A 342
TYR A 265
 None
 1.43A 4a83A-6ekvA:
1.4		 4a83A-6ekvA:
12.37