SIMILAR PATTERNS OF AMINO ACIDS FOR 4A81_A_DXCA1161

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1e09 PRU AV 1

(Prunus avium) 		PF00407
(Bet_v_1) 		5 ASP A  27
LYS A  54
ILE A  56
VAL A  67
TYR A  81
 None
 0.72A 4a81A-1e09A:
22.0		 4a81A-1e09A:
59.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1e09 PRU AV 1

(Prunus avium) 		PF00407
(Bet_v_1) 		5 LYS A  54
ILE A  56
VAL A  67
TYR A  81
LEU A 143
 None
 0.89A 4a81A-1e09A:
22.0		 4a81A-1e09A:
59.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1erz N-CARBAMYL-D-AMINO
ACID AMIDOHYDROLASE

(Agrobacterium
sp. KNK712) 		PF00795
(CN_hydrolase) 		5 ILE A  14
GLY A  12
ASP A 266
VAL A  43
ASN A 109
 None
 1.17A 4a81A-1erzA:
undetectable		 4a81A-1erzA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f2j FRUCTOSE-BISPHOSPHAT
E ALDOLASE,
GLYCOSOMAL

(Trypanosoma
brucei) 		PF00274
(Glycolytic) 		5 GLY A 276
ILE A 270
VAL A 269
ASN A 241
LEU A 307
 None
 1.23A 4a81A-1f2jA:
undetectable		 4a81A-1f2jA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g8x MYOSIN II HEAVY
CHAIN FUSED TO
ALPHA-ACTININ 3

(Dictyostelium
discoideum) 		PF00063
(Myosin_head)
PF00435
(Spectrin)
PF02736
(Myosin_N) 		5 ILE A 471
GLY A 457
LYS A 185
ASP A 454
LEU A 478
 None
None
ADP  A1100 (-3.2A)
MG  A1101 ( 4.3A)
None
 1.14A 4a81A-1g8xA:
undetectable		 4a81A-1g8xA:
10.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gnz GSI-B4 ISOLECTIN

(Griffonia
simplicifolia) 		PF00139
(Lectin_legB) 		5 GLY A 215
ILE A 175
VAL A 186
ASN A 148
LEU A  90
 None
 1.21A 4a81A-1gnzA:
0.0		 4a81A-1gnzA:
21.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ifv PROTEIN LLR18B

(Lupinus luteus) 		PF00407
(Bet_v_1) 		5 ASP A  27
LYS A  53
ILE A  55
VAL A  66
TYR A  80
 None
 0.65A 4a81A-1ifvA:
21.1		 4a81A-1ifvA:
49.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iy9 SPERMIDINE SYNTHASE

(Bacillus
subtilis) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		5 GLY A 234
VAL A  83
TYR A 173
ASN A 166
LEU A 180
 None
 1.07A 4a81A-1iy9A:
undetectable		 4a81A-1iy9A:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jae ALPHA-AMYLASE

(Tenebrio
molitor) 		PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C) 		5 ILE A 198
GLY A 201
ILE A 175
VAL A 179
ASN A  46
 None
 1.20A 4a81A-1jaeA:
undetectable		 4a81A-1jaeA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mio NITROGENASE
MOLYBDENUM IRON
PROTEIN (BETA CHAIN)

(Clostridium
pasteurianum) 		PF00148
(Oxidored_nitro) 		5 ILE B 337
GLY B 312
ILE B 441
VAL B 440
LEU B 334
 None
 1.19A 4a81A-1mioB:
undetectable		 4a81A-1mioB:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n11 ANKYRIN

(Homo sapiens) 		PF00023
(Ank)
PF12796
(Ank_2)
PF13637
(Ank_4)
PF13857
(Ank_5) 		5 ILE A 749
GLY A 745
ILE A 773
ASN A 728
LEU A 786
 None
 1.24A 4a81A-1n11A:
undetectable		 4a81A-1n11A:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sg9 HEMK PROTEIN

(Thermotoga
maritima) 		PF05175
(MTS) 		5 GLY A 225
ASP A 224
ILE A 258
VAL A 259
MET A 245
 None
 1.15A 4a81A-1sg9A:
undetectable		 4a81A-1sg9A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1svx ANKYRIN REPEAT
PROTEIN OFF7

(-) 		PF00023
(Ank)
PF12796
(Ank_2) 		5 ILE A 128
GLY A 124
ILE A 152
ASN A 107
LEU A 165
 None
 1.07A 4a81A-1svxA:
undetectable		 4a81A-1svxA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1te2 2-DEOXYGLUCOSE-6-P
PHOSPHATASE

(Escherichia
coli) 		PF13419
(HAD_2) 		5 GLY A  51
ILE A  54
VAL A  76
ASP A  55
MET A 121
 PGA  A 711 (-3.3A)
None
None
None
None
 1.07A 4a81A-1te2A:
undetectable		 4a81A-1te2A:
20.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1txc PATHOGENESIS-RELATED
CLASS 10 PROTEIN
SPE-16

(Pachyrhizus
erosus) 		PF00407
(Bet_v_1) 		5 ASP A  27
LYS A  53
ILE A  55
VAL A  66
TYR A  80
 None
None
2AN  A 716 (-4.2A)
2AN  A 716 (-4.0A)
None
 0.80A 4a81A-1txcA:
21.9		 4a81A-1txcA:
40.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1typ TRYPANOTHIONE
REDUCTASE

(Crithidia
fasciculata) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 GLY A 431
ASP A 432
ILE A 369
ASP A  71
LEU A 238
 None
 1.23A 4a81A-1typA:
undetectable		 4a81A-1typA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uxt GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(NADP+)

(Thermoproteus
tenax) 		PF00171
(Aldedh) 		5 ILE A 435
GLY A 429
ASP A 275
VAL A 406
ASN A 417
 None
 1.23A 4a81A-1uxtA:
undetectable		 4a81A-1uxtA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w61 B-CELL MITOGEN

(Trypanosoma
cruzi) 		PF05544
(Pro_racemase) 		5 ILE A 273
GLY A 244
ILE A 251
VAL A 255
LEU A 202
 None
 1.19A 4a81A-1w61A:
undetectable		 4a81A-1w61A:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wch PROTEIN TYROSINE
PHOSPHATASE,
NON-RECEPTOR TYPE 13

(Homo sapiens) 		PF00102
(Y_phosphatase) 		5 GLY A2190
ASP A2431
ILE A2428
VAL A2424
LEU A2197
 None
 1.22A 4a81A-1wchA:
undetectable		 4a81A-1wchA:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xqp 8-OXOGUANINE DNA
GLYCOSYLASE

(Pyrobaculum
aerophilum) 		PF09171
(AGOG) 		5 ILE A 167
GLY A 123
VAL A 133
MET A  52
LEU A 149
 None
 1.13A 4a81A-1xqpA:
undetectable		 4a81A-1xqpA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b39 C3

(Bos taurus) 		PF00207
(A2M)
PF01759
(NTR)
PF01821
(ANATO)
PF01835
(A2M_N)
PF07677
(A2M_recep)
PF07678
(A2M_comp)
PF07703
(A2M_N_2)
PF10569
(Thiol-ester_cl) 		5 ILE A1401
ILE A1387
VAL A1364
MET A1406
LEU A1442
 None
 1.19A 4a81A-2b39A:
undetectable		 4a81A-2b39A:
6.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e3d UTP--GLUCOSE-1-PHOSP
HATE
URIDYLYLTRANSFERASE

(Escherichia
coli) 		PF00483
(NTP_transferase) 		5 ILE A 134
GLY A 216
ILE A 167
VAL A 254
LEU A 241
 None
 1.23A 4a81A-2e3dA:
undetectable		 4a81A-2e3dA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nn5 HYPOTHETICAL PROTEIN
EF_2215

(Enterococcus
faecalis) 		PF08327
(AHSA1) 		5 GLY A 120
ASP A 117
ILE A  86
VAL A  79
LEU A 125
 None
 0.95A 4a81A-2nn5A:
10.3		 4a81A-2nn5A:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w9x PUTATIVE ACETYL
XYLAN ESTERASE

(Cellvibrio
japonicus) 		PF00657
(Lipase_GDSL) 		5 ILE A 242
GLY A 149
ASP A 150
ASP A 248
ASN A 272
 None
 1.07A 4a81A-2w9xA:
undetectable		 4a81A-2w9xA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xij METHYLMALONYL-COA
MUTASE,
MITOCHONDRIAL

(Homo sapiens) 		PF01642
(MM_CoA_mutase)
PF02310
(B12-binding) 		5 GLY A 563
ASP A 147
VAL A 162
ASP A 169
MET A 188
 None
 1.23A 4a81A-2xijA:
undetectable		 4a81A-2xijA:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ynm LIGHT-INDEPENDENT
PROTOCHLOROPHYLLIDE
REDUCTASE SUBUNIT B

(Prochlorococcus
marinus) 		PF00148
(Oxidored_nitro)
PF08369
(PCP_red) 		5 ILE D 516
GLY D 485
ILE D 492
ASN D 503
LEU D 522
 None
 0.98A 4a81A-2ynmD:
undetectable		 4a81A-2ynmD:
15.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ywr PHOSPHORIBOSYLGLYCIN
AMIDE
FORMYLTRANSFERASE

(Aquifex
aeolicus) 		PF00551
(Formyl_trans_N) 		5 ILE A  31
GLY A   5
ILE A 106
VAL A 137
LEU A   2
 None
 1.16A 4a81A-2ywrA:
undetectable		 4a81A-2ywrA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yxg DIHYDRODIPICOLINATE
SYNTHASE

(Methanocaldococcus
jannaschii) 		PF00701
(DHDPS) 		5 ILE A 192
GLY A 197
ILE A 179
ASN A 133
ASN A 141
 None
 1.04A 4a81A-2yxgA:
undetectable		 4a81A-2yxgA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zqq METHYLGLUTACONYL-COA
HYDRATASE

(Homo sapiens) 		PF00378
(ECH_1) 		5 GLY A 220
ILE A 228
VAL A 251
MET A 205
LEU A 188
 None
 1.14A 4a81A-2zqqA:
undetectable		 4a81A-2zqqA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a6p EXPORTIN-5

(Homo sapiens) 		PF08389
(Xpo1) 		5 GLY A  67
ILE A 119
VAL A 120
ASN A 100
LEU A  52
 None
 1.12A 4a81A-3a6pA:
undetectable		 4a81A-3a6pA:
9.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bgw DNAB-LIKE
REPLICATIVE HELICASE

(Bacillus phage
SPP1) 		PF00772
(DnaB)
PF03796
(DnaB_C) 		5 ILE A 175
GLY A 191
ILE A 311
VAL A 226
ASP A 224
 None
 1.04A 4a81A-3bgwA:
undetectable		 4a81A-3bgwA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bh0 DNAB-LIKE
REPLICATIVE HELICASE

(Bacillus phage
SPP1) 		PF03796
(DnaB_C) 		5 ILE A 175
GLY A 191
ILE A 311
VAL A 226
ASP A 224
 None
 0.87A 4a81A-3bh0A:
undetectable		 4a81A-3bh0A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bhi CARBONYL REDUCTASE
[NADPH] 1

(Homo sapiens) 		PF00106
(adh_short) 		5 ILE A  20
GLY A  12
ILE A  63
ASN A 136
LEU A   8
 None
NAP  A 309 ( 4.8A)
NAP  A 309 (-4.2A)
None
None
 0.93A 4a81A-3bhiA:
undetectable		 4a81A-3bhiA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e05 PRECORRIN-6Y
C5,15-METHYLTRANSFER
ASE
(DECARBOXYLATING)

(Geobacter
metallireducens) 		no annotation 5 ILE A 255
GLY A 323
ILE A 398
VAL A 370
LEU A 329
 None
 1.19A 4a81A-3e05A:
undetectable		 4a81A-3e05A:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ebl GIBBERELLIN RECEPTOR
GID1

(Oryza sativa) 		PF07859
(Abhydrolase_3) 		5 ILE A 203
GLY A 196
ASP A 197
TYR A 154
ASN A 153
 None
None
GA4  A 401 (-4.2A)
None
None
 0.97A 4a81A-3eblA:
undetectable		 4a81A-3eblA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ecq ENDO-ALPHA-N-ACETYLG
ALACTOSAMINIDASE

(Streptococcus
pneumoniae) 		PF12905
(Glyco_hydro_101)
PF17451
(Glyco_hyd_101C) 		5 ILE A1209
ASP A1061
ILE A1083
VAL A1084
LEU A1104
 None
 1.07A 4a81A-3ecqA:
undetectable		 4a81A-3ecqA:
7.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ekm DIAMINOPIMELATE
EPIMERASE,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF01678
(DAP_epimerase) 		5 ILE A 131
ILE A 286
VAL A 277
ASN A 101
ASN A  37
 None
None
None
ZDR  A 500 (-3.7A)
ZDR  A 500 (-3.4A)
 1.09A 4a81A-3ekmA:
undetectable		 4a81A-3ekmA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fle SE_1780 PROTEIN

(Staphylococcus
epidermidis) 		PF06028
(DUF915) 		5 GLY A 195
ASP A 192
ILE A 190
ASN A 201
ASN A 183
 None
 0.93A 4a81A-3fleA:
undetectable		 4a81A-3fleA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT B

(Sulfolobus
solfataricus) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5) 		5 ILE B 161
GLY B 347
ASP B 348
ILE B 476
VAL B 575
 None
 1.13A 4a81A-3hkzB:
undetectable		 4a81A-3hkzB:
10.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ive NUCLEOTIDASE

(Escherichia
coli) 		PF00149
(Metallophos)
PF02872
(5_nucleotid_C) 		5 ILE A 109
GLY A  78
ASP A  79
ASP A 115
ASN A 120
 None
None
FE  A 602 (-2.6A)
CTN  A 603 ( 4.1A)
None
 0.92A 4a81A-3iveA:
undetectable		 4a81A-3iveA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3izq ELONGATION FACTOR 1
ALPHA-LIKE PROTEIN

(Saccharomyces
cerevisiae) 		PF00009
(GTP_EFTU)
PF03143
(GTP_EFTU_D3)
PF08938
(HBS1_N) 		5 ILE 1 578
GLY 1 489
ASP 1 490
ILE 1 500
LEU 1 589
 None
 1.02A 4a81A-3izq1:
undetectable		 4a81A-3izq1:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jb9 SMALL NUCLEAR
RIBONUCLEOPROTEIN E
SMALL NUCLEAR
RIBONUCLEOPROTEIN F
SMALL NUCLEAR
RIBONUCLEOPROTEIN G

(Schizosaccharomyces
pombe;
Schizosaccharomyces
pombe;
Schizosaccharomyces
pombe) 		PF01423
(LSM)
PF01423
(LSM)
PF01423
(LSM) 		5 GLY I  27
ILE H  36
ASP H  35
ASN J  22
LEU I  71
 None
 1.18A 4a81A-3jb9I:
undetectable		 4a81A-3jb9I:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k50 PUTATIVE S41
PROTEASE

(Bacteroides
fragilis) 		PF03572
(Peptidase_S41) 		5 GLY A 163
ILE A 116
VAL A 119
MET A 187
LEU A 160
 None
None
CL  A   1 (-4.4A)
None
None
 1.14A 4a81A-3k50A:
undetectable		 4a81A-3k50A:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k50 PUTATIVE S41
PROTEASE

(Bacteroides
fragilis) 		PF03572
(Peptidase_S41) 		5 ILE A 182
ILE A 116
VAL A 119
MET A 187
LEU A 160
 None
None
CL  A   1 (-4.4A)
None
None
 0.99A 4a81A-3k50A:
undetectable		 4a81A-3k50A:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k7t 6-HYDROXY-L-NICOTINE
OXIDASE

(Paenarthrobacter
nicotinovorans) 		PF01593
(Amino_oxidase) 		5 ILE A 252
GLY A   8
ILE A 220
ASN A  22
LEU A  14
 None
FAD  A 434 (-3.2A)
None
None
None
 1.23A 4a81A-3k7tA:
undetectable		 4a81A-3k7tA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kfu GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT C

(Thermus
thermophilus;
Thermus
thermophilus) 		PF01425
(Amidase)
PF02686
(Glu-tRNAGln) 		5 GLY E 163
ASP E 407
VAL G  39
TYR E 193
LEU E 415
 None
 1.07A 4a81A-3kfuE:
undetectable		 4a81A-3kfuE:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nok GLUTAMINYL CYCLASE

(Myxococcus
xanthus) 		PF05096
(Glu_cyclase_2) 		5 ILE A 181
ILE A 237
VAL A 250
ASN A 184
ASN A 226
 None
 1.00A 4a81A-3nokA:
undetectable		 4a81A-3nokA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pt1 UPF0364 PROTEIN
YMR027W

(Saccharomyces
cerevisiae) 		PF01937
(DUF89) 		5 ILE A 187
ASP A 263
LYS A 382
ILE A 380
LEU A 270
 None
 1.21A 4a81A-3pt1A:
undetectable		 4a81A-3pt1A:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ptk BETA-GLUCOSIDASE
OS4BGLU12

(Oryza sativa) 		PF00232
(Glyco_hydro_1) 		5 ILE A 271
GLY A 276
ASP A 280
TYR A 379
LEU A 249
 None
 0.93A 4a81A-3ptkA:
undetectable		 4a81A-3ptkA:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ptk BETA-GLUCOSIDASE
OS4BGLU12

(Oryza sativa) 		PF00232
(Glyco_hydro_1) 		5 ILE A 271
GLY A 276
ILE A 283
TYR A 379
LEU A 249
 None
 1.04A 4a81A-3ptkA:
undetectable		 4a81A-3ptkA:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pw9 UPF0603 PROTEIN
AT1G54780,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF04536
(TPM_phosphatase) 		5 GLY A  93
ILE A 133
VAL A 169
TYR A 156
LEU A  90
 None
None
None
None
GOL  A 303 ( 4.7A)
 1.14A 4a81A-3pw9A:
undetectable		 4a81A-3pw9A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rhg PUTATIVE
PHOPHOTRIESTERASE

(Proteus
mirabilis) 		PF02126
(PTE) 		5 ILE A 146
GLY A 165
ILE A 225
ASN A 189
LEU A 181
 None
 1.12A 4a81A-3rhgA:
undetectable		 4a81A-3rhgA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vrd FLAVOCYTOCHROME C
FLAVIN SUBUNIT

(Thermochromatium
tepidum) 		PF07992
(Pyr_redox_2)
PF09242
(FCSD-flav_bind) 		5 ILE B 347
GLY B 203
ILE B 217
VAL B 185
ASN B  46
 None
None
None
None
FAD  B 501 ( 3.6A)
 1.24A 4a81A-3vrdB:
undetectable		 4a81A-3vrdB:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aca TRANSLATION
ELONGATION FACTOR
SELB

(Methanococcus
maripaludis) 		PF00009
(GTP_EFTU)
PF03144
(GTP_EFTU_D2) 		5 ILE A 223
ILE A 252
VAL A 229
MET A 188
LEU A 190
 None
None
None
None
CMH  A 264 ( 4.1A)
 1.21A 4a81A-4acaA:
undetectable		 4a81A-4acaA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4avy PROBABLE SHORT-CHAIN
DEHYDROGENASE

(Pseudomonas
aeruginosa) 		PF13561
(adh_short_C2) 		5 ILE A  26
GLY A  18
ILE A  62
ASN A 130
LEU A  14
 None
 1.08A 4a81A-4avyA:
undetectable		 4a81A-4avyA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b3k BETA-GLUCOSIDASE

(Streptococcus
pyogenes) 		PF00232
(Glyco_hydro_1) 		5 GLY A  16
ILE A 115
VAL A 157
TYR A  98
ASN A 100
 None
 1.21A 4a81A-4b3kA:
undetectable		 4a81A-4b3kA:
17.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4c94 FRA A 3 ALLERGEN

(Fragaria x
ananassa) 		PF00407
(Bet_v_1) 		6 ASP A  28
LYS A  55
ILE A  57
VAL A  68
TYR A  82
LEU A 143
 None
None
KXN  A 160 ( 4.7A)
None
None
None
 0.93A 4a81A-4c94A:
24.6		 4a81A-4c94A:
58.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h1s 5'-NUCLEOTIDASE

(Homo sapiens) 		PF00149
(Metallophos)
PF02872
(5_nucleotid_C) 		5 ILE A 343
GLY A 404
ILE A 532
MET A 360
LEU A 346
 None
 1.10A 4a81A-4h1sA:
undetectable		 4a81A-4h1sA:
14.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hdt 3-HYDROXYISOBUTYRYL-
COA HYDROLASE

(Mycolicibacterium
thermoresistibile) 		PF16113
(ECH_2) 		5 ILE A  98
GLY A 119
VAL A 129
TYR A 105
LEU A 153
 None
 1.21A 4a81A-4hdtA:
undetectable		 4a81A-4hdtA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i0o PROTEIN ELYS

(Mus musculus) 		PF16687
(ELYS-bb) 		5 GLY A 242
ASP A 241
ILE A 223
VAL A 159
TYR A 257
 None
 1.12A 4a81A-4i0oA:
undetectable		 4a81A-4i0oA:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jgp SPORULATION KINASE D

(Bacillus
subtilis) 		PF02743
(dCache_1) 		5 ILE A 153
GLY A 105
ASN A 110
MET A  89
LEU A  93
 PYR  A 301 (-3.9A)
None
None
None
None
 1.23A 4a81A-4jgpA:
undetectable		 4a81A-4jgpA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jz7 CARBAMATE KINASE

(Giardia
intestinalis) 		PF00696
(AA_kinase) 		5 ILE A 180
ILE A   9
ASN A 194
MET A  97
LEU A 189
 None
 1.02A 4a81A-4jz7A:
undetectable		 4a81A-4jz7A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lds BICYCLOMYCIN
RESISTANCE PROTEIN
TCAB

(Staphylococcus
epidermidis) 		PF00083
(Sugar_tr) 		5 ILE A  46
GLY A  45
ILE A  26
VAL A  25
LEU A  52
 None
 1.18A 4a81A-4ldsA:
undetectable		 4a81A-4ldsA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n6s C-PHYCOCYANIN BETA
SUBUNIT

(Thermosynechococcus
vulcanus) 		PF00502
(Phycobilisome) 		5 ILE B 162
GLY B 164
ASP B 167
ILE B 133
LEU B 107
 None
 1.03A 4a81A-4n6sB:
undetectable		 4a81A-4n6sB:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4na3 POLYKETIDE SYNTHASE
PKSJ

(Bacillus
subtilis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		5 ILE A 371
GLY A 244
ILE A  68
ASN A  28
LEU A 361
 None
 1.21A 4a81A-4na3A:
undetectable		 4a81A-4na3A:
14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oj5 TAILSPIKE PROTEIN

(Escherichia
virus CBA120) 		no annotation 5 GLY A 759
ASP A 758
ILE A 730
ASN A 714
LEU A 763
 None
 1.15A 4a81A-4oj5A:
undetectable		 4a81A-4oj5A:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4per RIBONUCLEASE
INHIBITOR

(Gallus gallus) 		PF13516
(LRR_6) 		5 GLY A 235
ILE A 206
VAL A 182
ASP A 179
LEU A 242
 None
 1.17A 4a81A-4perA:
undetectable		 4a81A-4perA:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rkm MCCA

(Wolinella
succinogenes) 		no annotation 5 GLY A 273
ASP A 274
LYS A 291
VAL A 236
LEU A 269
 None
 1.01A 4a81A-4rkmA:
undetectable		 4a81A-4rkmA:
14.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s3k SPORE GERMINATION
PROTEIN YAAH

(Bacillus
megaterium) 		PF00704
(Glyco_hydro_18)
PF01476
(LysM) 		5 ILE A 420
GLY A 104
ILE A 318
VAL A 279
ASN A 322
 None
 1.23A 4a81A-4s3kA:
undetectable		 4a81A-4s3kA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tv6 2-DEHYDRO-3-DEOXYGLU
CARATE ALDOLASE

(Staphylococcus
aureus) 		PF03328
(HpcH_HpaI) 		5 ILE A 233
GLY A 235
VAL A  48
ASP A  44
MET A  29
 None
 1.21A 4a81A-4tv6A:
undetectable		 4a81A-4tv6A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u3v POLYKETIDE SYNTHASE
PKSR

(Bacillus
subtilis) 		PF14765
(PS-DH) 		5 ILE A 206
GLY A 253
ILE A 224
ASN A 182
LEU A 256
 None
 1.21A 4a81A-4u3vA:
undetectable		 4a81A-4u3vA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u9i PERIPLASMIC [NIFE]
HYDROGENASE LARGE
SUBUNIT

(Desulfovibrio
vulgaris) 		PF00374
(NiFeSe_Hases) 		5 GLY L 425
ILE L 432
VAL L 436
ASN L 476
LEU L 392
 None
None
None
None
MPD  L 604 ( 4.4A)
 1.16A 4a81A-4u9iL:
undetectable		 4a81A-4u9iL:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wep PUTATIVE
OSMOPROTECTANT
UPTAKE SYSTEM
SUBSTRATE-BINDING
PROTEIN OSMF

(Escherichia
coli) 		PF04069
(OpuAC) 		5 GLY A 197
ASP A 198
ILE A 203
VAL A 225
ASP A 222
 None
 1.21A 4a81A-4wepA:
undetectable		 4a81A-4wepA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xe7 UNCHARACTERIZED
PROTEIN

(Bacillus
thuringiensis) 		no annotation 5 GLY A 142
LYS A 187
ILE A 189
VAL A 177
LEU A  11
 None
 1.21A 4a81A-4xe7A:
undetectable		 4a81A-4xe7A:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xhp PARM HYBRID FUSION
PROTEIN

(Bacillus
thuringiensis) 		no annotation 5 GLY A 142
LYS A 187
ILE A 189
VAL A 177
LEU A  11
 None
 1.06A 4a81A-4xhpA:
undetectable		 4a81A-4xhpA:
12.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xhp PARM HYBRID FUSION
PROTEIN

(Bacillus
thuringiensis) 		no annotation 5 GLY A 585
LYS A 630
ILE A 632
VAL A 620
LEU A 454
 None
 1.15A 4a81A-4xhpA:
undetectable		 4a81A-4xhpA:
12.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xqk LLABIII

(Lactococcus
lactis) 		PF00271
(Helicase_C)
PF02384
(N6_Mtase)
PF04851
(ResIII)
PF13156
(Mrr_cat_2) 		5 ILE A 437
GLY A 669
VAL A 429
ASN A 628
LEU A 691
 None
 1.22A 4a81A-4xqkA:
undetectable		 4a81A-4xqkA:
7.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ynn PROTEASE DO

(Legionella
pneumophila) 		PF13180
(PDZ_2)
PF13365
(Trypsin_2) 		5 ILE A  77
ILE A 202
ASN A 205
ASN A 189
LEU A 125
 None
 1.21A 4a81A-4ynnA:
undetectable		 4a81A-4ynnA:
19.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4z3l MAJOR POLLEN
ALLERGEN BET V 1-A

(Betula pendula) 		PF00407
(Bet_v_1) 		8 ILE A  23
ASP A  27
LYS A  54
ILE A  56
VAL A  67
ASN A 100
MET A 139
LEU A 143
 None
 0.64A 4a81A-4z3lA:
28.3		 4a81A-4z3lA:
97.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4z3l MAJOR POLLEN
ALLERGEN BET V 1-A

(Betula pendula) 		PF00407
(Bet_v_1) 		9 ILE A  23
ASP A  27
LYS A  54
ILE A  56
VAL A  67
TYR A  81
ASN A 100
ASN A 118
LEU A 143
 None
 0.60A 4a81A-4z3lA:
28.3		 4a81A-4z3lA:
97.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zm6 N-ACETYL-BETA-D
GLUCOSAMINIDASE

(Rhizomucor
miehei) 		PF00583
(Acetyltransf_1)
PF00933
(Glyco_hydro_3) 		5 ILE A 525
GLY A 152
ILE A 146
TYR A 484
ASN A 454
 None
 1.15A 4a81A-4zm6A:
undetectable		 4a81A-4zm6A:
11.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a55 ENDO-ALPHA-N-ACETYLG
ALACTOSAMINIDASE

(Streptococcus
pneumoniae) 		PF12905
(Glyco_hydro_101)
PF17451
(Glyco_hyd_101C) 		5 ILE A1209
ASP A1061
ILE A1083
VAL A1084
LEU A1104
 None
 1.08A 4a81A-5a55A:
undetectable		 4a81A-5a55A:
8.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5amw FRA A 2 ALLERGEN

(Fragaria x
ananassa) 		PF00407
(Bet_v_1) 		6 ILE A  24
ASP A  28
ILE A  57
VAL A  68
TYR A  82
LEU A 144
 None
 0.81A 4a81A-5amwA:
24.6		 4a81A-5amwA:
58.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5amw FRA A 2 ALLERGEN

(Fragaria x
ananassa) 		PF00407
(Bet_v_1) 		5 ILE A  24
ASP A  28
LYS A  55
TYR A  82
LEU A 144
 None
 0.79A 4a81A-5amwA:
24.6		 4a81A-5amwA:
58.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5c9y PROTEIN LLR18A

(Lupinus luteus) 		PF00407
(Bet_v_1) 		5 ASP A  27
LYS A  53
ILE A  55
VAL A  66
LEU A 141
 None
 1.03A 4a81A-5c9yA:
21.1		 4a81A-5c9yA:
47.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5c9y PROTEIN LLR18A

(Lupinus luteus) 		PF00407
(Bet_v_1) 		5 ASP A  27
LYS A  53
ILE A  55
VAL A  66
TYR A  80
 None
 0.49A 4a81A-5c9yA:
21.1		 4a81A-5c9yA:
47.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cbn MBP3-16,IMMUNOGLOBUL
IN G-BINDING PROTEIN
A

(Staphylococcus
aureus;
synthetic
construct) 		PF02216
(B)
PF12796
(Ank_2) 		5 ILE A  95
GLY A  91
ILE A 119
ASN A  74
LEU A 132
 None
 1.08A 4a81A-5cbnA:
undetectable		 4a81A-5cbnA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d04 PHOSPHO-2-DEHYDRO-3-
DEOXYHEPTONATE
ALDOLASE

(Neisseria
meningitidis) 		PF00793
(DAHP_synth_1) 		5 ILE C  60
ILE C 234
ASP C 267
MET C 299
LEU C  57
 None
 1.16A 4a81A-5d04C:
undetectable		 4a81A-5d04C:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5diy HYALURONIDASE

(Thermobaculum
terrenum) 		PF07555
(NAGidase) 		5 ILE A 162
GLY A 115
VAL A 121
ASP A 119
LEU A 145
 None
 1.13A 4a81A-5diyA:
undetectable		 4a81A-5diyA:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ejj UFM1-SPECIFIC
PROTEASE

(Caenorhabditis
elegans) 		PF07910
(Peptidase_C78) 		6 ILE A  17
VAL A  57
ASP A  18
ASN A  25
ASN A 338
LEU A 108
 None
 1.22A 4a81A-5ejjA:
undetectable		 4a81A-5ejjA:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5evj ARSENITE
METHYLTRANSFERASE

(Chlamydomonas
reinhardtii) 		PF13847
(Methyltransf_31) 		5 GLY A  93
ASP A 115
ILE A 150
VAL A 181
ASN A 173
 None
 1.12A 4a81A-5evjA:
undetectable		 4a81A-5evjA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5itw DIHYDROANTICAPSIN
7-DEHYDROGENASE

(Bacillus
subtilis) 		PF13561
(adh_short_C2) 		5 GLY A  15
ASP A  38
ILE A  63
ASN A 138
LEU A  11
 None
 1.02A 4a81A-5itwA:
undetectable		 4a81A-5itwA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jmv PROBABLE
BIFUNCTIONAL TRNA
THREONYLCARBAMOYLADE
NOSINE BIOSYNTHESIS
PROTEIN

(Methanocaldococcus
jannaschii) 		PF00814
(Peptidase_M22) 		5 GLY A 283
ASP A 284
ILE A 289
VAL A 104
TYR A 127
 AMP  A 401 (-3.5A)
MG  A 402 ( 2.7A)
None
None
MG  A 402 (-4.7A)
 1.17A 4a81A-5jmvA:
undetectable		 4a81A-5jmvA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jqk PEPTIDASE, PUTATIVE

(Plasmodium
falciparum) 		PF00557
(Peptidase_M24)
PF01321
(Creatinase_N)
PF16188
(Peptidase_M24_C)
PF16189
(Creatinase_N_2) 		5 ASP A 381
ILE A 385
VAL A 407
ASN A 355
LEU A 328
 None
 0.99A 4a81A-5jqkA:
undetectable		 4a81A-5jqkA:
12.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mz9 -

(-) 		no annotation 5 ILE A 633
GLY A 647
ILE A 546
ASP A 666
ASN A 306
 None
 1.09A 4a81A-5mz9A:
undetectable		 4a81A-5mz9A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n2g DNA POLYMERASE

(Vaccinia virus) 		no annotation 5 ILE A 695
GLY A 750
ILE A 547
ASP A 549
ASN A 779
 None
None
None
MN  A1106 ( 4.6A)
None
 1.22A 4a81A-5n2gA:
2.1		 4a81A-5n2gA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ocd -

(-) 		no annotation 5 ILE A 111
ASP A 116
VAL A  67
ASP A  65
LEU A  30
 None
 1.05A 4a81A-5ocdA:
undetectable		 4a81A-5ocdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wna MAB 3D3 FAB HEAVY
CHAIN

(Homo sapiens) 		no annotation 5 GLY H  24
ILE H  98
VAL H 100
ASN H  54
LEU H  79
 None
 1.21A 4a81A-5wnaH:
undetectable		 4a81A-5wnaH:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y6q ALDEHYDE OXIDASE
MEDIUM SUBUNIT

(Methylobacillus
sp. KY4400) 		no annotation 5 GLY B 164
ASP B 165
LYS B 232
VAL B 318
ASN B 308
 FAD  B 401 (-3.4A)
FAD  B 401 (-3.5A)
FAD  B 401 (-2.7A)
None
None
 1.11A 4a81A-5y6qB:
undetectable		 4a81A-5y6qB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bnp UNCONVENTIONAL
MYOSIN-VI

(Sus scrofa) 		no annotation 5 ILE I 518
GLY I 524
ASP I 527
VAL I 643
TYR I 475
 None
 1.21A 4a81A-6bnpI:
undetectable		 4a81A-6bnpI:
undetectable