SIMILAR PATTERNS OF AMINO ACIDS FOR 4A7T_F_5FWF1001

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aj8 CITRATE SYNTHASE

(Pyrococcus
furiosus) 		PF00285
(Citrate_synt) 		4 GLU A  47
LYS A  68
PRO A  59
GLU A  48
 None
 1.49A 4a7tF-1aj8A:
undetectable		 4a7tF-1aj8A:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c8n COAT PROTEIN

(unidentified
tobacco
necrosis virus) 		PF00729
(Viral_coat) 		4 GLU A 268
LYS A 131
LYS A  87
GLU A 265
 None
 1.30A 4a7tF-1c8nA:
0.0		 4a7tF-1c8nA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dbh PROTEIN (HUMAN SOS
1)

(Homo sapiens) 		PF00169
(PH)
PF00621
(RhoGEF) 		4 GLU A 361
LYS A 370
LYS A 363
GLU A 365
 None
 1.43A 4a7tF-1dbhA:
0.0		 4a7tF-1dbhA:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1elj MALTODEXTRIN-BINDING
PROTEIN

(Pyrococcus
furiosus) 		PF13416
(SBP_bac_8) 		4 GLU A 136
LYS A 132
PRO A 249
GLU A 256
 None
 1.45A 4a7tF-1eljA:
0.0		 4a7tF-1eljA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mjh PROTEIN (ATP-BINDING
DOMAIN OF PROTEIN
MJ0577)

(Methanocaldococcus
jannaschii) 		PF00582
(Usp) 		4 GLU A  93
LYS A  89
LYS A  98
GLU A  35
 None
 1.20A 4a7tF-1mjhA:
0.0		 4a7tF-1mjhA:
23.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1p1v SUPEROXIDE DISMUTASE
[CU-ZN]

(Homo sapiens) 		PF00080
(Sod_Cu) 		4 GLU A  21
PRO A  28
TRP A  32
GLU A 100
 None
 0.73A 4a7tF-1p1vA:
30.2		 4a7tF-1p1vA:
98.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pjb L-ALANINE
DEHYDROGENASE

(Phormidium
lapideum) 		PF01262
(AlaDh_PNT_C)
PF05222
(AlaDh_PNT_N) 		4 GLU A   8
LYS A  72
LYS A   7
GLU A  36
 None
 1.37A 4a7tF-1pjbA:
0.0		 4a7tF-1pjbA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ptj NAD(P)
TRANSHYDROGENASE
SUBUNIT ALPHA PART 1

(Rhodospirillum
rubrum) 		PF01262
(AlaDh_PNT_C)
PF05222
(AlaDh_PNT_N) 		4 GLU A   8
LYS A  73
LYS A   7
GLU A  36
 None
 1.41A 4a7tF-1ptjA:
undetectable		 4a7tF-1ptjA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vkc PUTATIVE ACETYL
TRANSFERASE

(Pyrococcus
furiosus) 		PF00583
(Acetyltransf_1) 		4 GLU A  52
LYS A  54
TRP A 111
GLU A   9
 None
 1.21A 4a7tF-1vkcA:
0.0		 4a7tF-1vkcA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xdv SON OF SEVENLESS
PROTEIN HOMOLOG 1

(Homo sapiens) 		PF00169
(PH)
PF00617
(RasGEF)
PF00618
(RasGEF_N)
PF00621
(RhoGEF) 		4 GLU A 361
LYS A 370
LYS A 363
GLU A 365
 None
 1.43A 4a7tF-1xdvA:
undetectable		 4a7tF-1xdvA:
9.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xfs CONSERVED
HYPOTHETICAL PROTEIN

(Nitrosomonas
europaea) 		PF08327
(AHSA1) 		4 GLU A 145
LYS A 142
PRO A 138
GLU A   9
 None
 0.98A 4a7tF-1xfsA:
undetectable		 4a7tF-1xfsA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c3o PYRUVATE-FERREDOXIN
OXIDOREDUCTASE

(Desulfovibrio
africanus) 		PF01558
(POR)
PF01855
(POR_N)
PF02775
(TPP_enzyme_C)
PF10371
(EKR)
PF13484
(Fer4_16)
PF17147
(PFOR_II) 		4 GLU A 472
LYS A 473
PRO A 414
LYS A 415
 None
 1.36A 4a7tF-2c3oA:
undetectable		 4a7tF-2c3oA:
9.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2de0 ALPHA-(1,6)-FUCOSYLT
RANSFERASE

(Homo sapiens) 		PF14604
(SH3_9) 		4 GLU X 183
PRO X 484
LYS X 185
GLU X 181
 None
 1.24A 4a7tF-2de0X:
undetectable		 4a7tF-2de0X:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dgk GLUTAMATE
DECARBOXYLASE BETA

(Escherichia
coli) 		PF00282
(Pyridoxal_deC) 		4 GLU A 364
LYS A 381
PRO A 362
GLU A 386
 None
 1.26A 4a7tF-2dgkA:
undetectable		 4a7tF-2dgkA:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eez ALANINE
DEHYDROGENASE

(Thermus
thermophilus) 		PF01262
(AlaDh_PNT_C)
PF05222
(AlaDh_PNT_N) 		4 GLU A   8
LYS A  71
LYS A   7
GLU A  36
 None
 1.31A 4a7tF-2eezA:
undetectable		 4a7tF-2eezA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2grv LPQW

(Mycolicibacterium
smegmatis) 		PF00496
(SBP_bac_5) 		4 GLU A 148
PRO A 104
LYS A 101
GLU A  86
 None
 1.38A 4a7tF-2grvA:
undetectable		 4a7tF-2grvA:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kp5 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Hahella
chejuensis) 		PF00030
(Crystall) 		4 GLU A  19
LYS A   6
PRO A  46
GLU A   2
 None
 1.11A 4a7tF-2kp5A:
undetectable		 4a7tF-2kp5A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ln7 LPXTG-SITE
TRANSPEPTIDASE
FAMILY PROTEIN

(Bacillus
anthracis) 		PF04203
(Sortase) 		4 GLU A 138
LYS A  97
TRP A  99
GLU A  78
 None
 1.45A 4a7tF-2ln7A:
undetectable		 4a7tF-2ln7A:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mg4 COMPUTATIONAL
DESIGNED HOMODIMER

(Drosophila
melanogaster) 		PF00046
(Homeobox) 		4 GLU A  11
LYS A   1
PRO A   5
GLU A   8
 None
 1.40A 4a7tF-2mg4A:
undetectable		 4a7tF-2mg4A:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q7n LEUKEMIA INHIBITORY
FACTOR RECEPTOR

(Mus musculus) 		PF00041
(fn3) 		4 GLU A 125
LYS A 127
TRP A 190
GLU A 135
 None
 1.32A 4a7tF-2q7nA:
2.8		 4a7tF-2q7nA:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qfq 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE

(Escherichia
coli) 		PF00275
(EPSP_synthase) 		4 GLU A 378
PRO A 406
LYS A   1
GLU A   2
 None
 1.48A 4a7tF-2qfqA:
undetectable		 4a7tF-2qfqA:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rb5 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Bacteroides
thetaiotaomicron) 		PF08282
(Hydrolase_3) 		4 GLU A 170
LYS A 184
PRO A  86
GLU A  89
 None
 1.13A 4a7tF-2rb5A:
undetectable		 4a7tF-2rb5A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yma PROTEIN OS-9 HOMOLOG

(Saccharomyces
cerevisiae) 		no annotation 4 GLU A 353
LYS A 299
PRO A 291
GLU A 296
 None
 1.49A 4a7tF-2ymaA:
undetectable		 4a7tF-2ymaA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zah COAT PROTEIN

(Melon necrotic
spot virus) 		PF00729
(Viral_coat) 		4 GLU A 255
LYS A  97
LYS A 257
TRP A 213
 None
 1.42A 4a7tF-2zahA:
undetectable		 4a7tF-2zahA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bma D-ALANYL-LIPOTEICHOI
C ACID SYNTHETASE

(Streptococcus
pneumoniae) 		PF04914
(DltD) 		4 GLU A 339
LYS A 329
PRO A 326
LYS A 366
 None
 1.45A 4a7tF-3bmaA:
undetectable		 4a7tF-3bmaA:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cih PUTATIVE
ALPHA-RHAMNOSIDASE

(Bacteroides
thetaiotaomicron) 		PF17389
(Bac_rhamnosid6H)
PF17390
(Bac_rhamnosid_C) 		4 GLU A 648
LYS A 643
LYS A 689
TRP A 718
 None
 1.35A 4a7tF-3cihA:
undetectable		 4a7tF-3cihA:
12.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3gtt SUPEROXIDE DISMUTASE
[CU-ZN]

(Mus musculus) 		PF00080
(Sod_Cu) 		4 GLU A  21
LYS A  23
PRO A  28
GLU A 100
 None
 0.83A 4a7tF-3gttA:
31.7		 4a7tF-3gttA:
83.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iwj PUTATIVE
AMINOALDEHYDE
DEHYDROGENASE

(Pisum sativum) 		PF00171
(Aldedh) 		4 GLU A  87
PRO A  90
LYS A  88
GLU A  91
 None
 1.17A 4a7tF-3iwjA:
undetectable		 4a7tF-3iwjA:
15.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l7o RIBOSE-5-PHOSPHATE
ISOMERASE A

(Streptococcus
mutans) 		PF06026
(Rib_5-P_isom_A) 		4 GLU A 147
PRO A 155
LYS A 150
GLU A 149
 None
 1.21A 4a7tF-3l7oA:
undetectable		 4a7tF-3l7oA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n93 MALTOSE BINDING
PROTEIN-CRFR2 ALPHA

(Homo sapiens) 		PF02793
(HRM)
PF13416
(SBP_bac_8) 		4 GLU A-367
LYS A-369
PRO A -99
GLU A-366
 None
 1.36A 4a7tF-3n93A:
undetectable		 4a7tF-3n93A:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zj1 NUCLEAR
POLYADENYLATED
RNA-BINDING PROTEIN
NAB2

(Saccharomyces
cerevisiae) 		no annotation 4 GLU A 312
PRO A 266
LYS A 309
GLU A 310
 None
 1.47A 4a7tF-3zj1A:
undetectable		 4a7tF-3zj1A:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zyx AMINE OXIDASE
[FLAVIN-CONTAINING]
B

(Homo sapiens) 		PF01593
(Amino_oxidase) 		4 GLU A 366
LYS A 362
PRO A 380
GLU A 379
 None
 1.36A 4a7tF-3zyxA:
undetectable		 4a7tF-3zyxA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e3a SUGAR KINASE PROTEIN

(Rhizobium etli) 		PF00294
(PfkB) 		4 PRO A 137
LYS A 164
TRP A 158
GLU A 165
 None
 1.24A 4a7tF-4e3aA:
undetectable		 4a7tF-4e3aA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hc3 PPCA

(Geobacter
sulfurreducens) 		no annotation 4 GLU A  56
LYS A  52
PRO A  62
GLU A  67
 None
SO4  A  77 (-4.7A)
HEM  A  73 ( 4.4A)
None
 1.40A 4a7tF-4hc3A:
undetectable		 4a7tF-4hc3A:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k8l PROLINE RACEMASE

(Ochrobactrum
anthropi) 		PF05544
(Pro_racemase) 		4 PRO A 214
LYS A 216
TRP A  35
GLU A 215
 None
 1.42A 4a7tF-4k8lA:
undetectable		 4a7tF-4k8lA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kcb ARABINAN
ENDO-1,5-ALPHA-L-ARA
BINOSIDASE

(uncultured
bacterium) 		PF04616
(Glyco_hydro_43) 		4 GLU A 141
LYS A 139
PRO A  78
GLU A  79
 None
 1.23A 4a7tF-4kcbA:
undetectable		 4a7tF-4kcbA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mlg BETA-XYLOSIDASE

(uncultured
organism) 		PF04616
(Glyco_hydro_43) 		4 GLU A 307
PRO A   4
LYS A   2
GLU A   3
 None
 1.29A 4a7tF-4mlgA:
undetectable		 4a7tF-4mlgA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4po6 INTERFERON
ALPHA/BETA RECEPTOR
1
NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		no annotation 4 GLU B 500
PRO A 506
LYS B 501
GLU A 517
 None
 1.34A 4a7tF-4po6B:
undetectable		 4a7tF-4po6B:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r1j GU4 NUCLEIC-BINDING
PROTEIN 1

(Saccharomyces
cerevisiae) 		PF01588
(tRNA_bind) 		4 GLU A 141
LYS A 166
PRO A  97
GLU A 163
 None
 1.47A 4a7tF-4r1jA:
undetectable		 4a7tF-4r1jA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rgt PUTATIVE
UNCHARACTERIZED
PROTEIN

(Staphylococcus
aureus) 		PF02876
(Stap_Strp_tox_C)
PF09199
(SSL_OB) 		4 GLU A 229
LYS A 186
LYS A 188
GLU A 202
 None
None
None
GAL  A 402 (-3.6A)
 1.27A 4a7tF-4rgtA:
undetectable		 4a7tF-4rgtA:
19.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xcr SUPEROXIDE DISMUTASE
[CU-ZN]

(Homo sapiens) 		PF00080
(Sod_Cu) 		4 GLU A  21
PRO A  28
LYS A  30
GLU A  70
 None
 0.73A 4a7tF-4xcrA:
16.2		 4a7tF-4xcrA:
67.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cdh MAJOR ACID
PHOSPHATASE

(Legionella
pneumophila) 		PF00328
(His_Phos_2) 		4 GLU A 171
LYS A 175
TRP A 235
GLU A 178
 None
1PE  A 402 (-3.0A)
1PE  A 402 (-4.0A)
1PE  A 402 (-3.7A)
 1.20A 4a7tF-5cdhA:
undetectable		 4a7tF-5cdhA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fly FERRICHROME-BINDING
PERIPLASMIC PROTEIN

(Staphylococcus
pseudintermedius) 		PF01497
(Peripla_BP_2) 		4 GLU A   4
LYS A  23
PRO A  22
LYS A   3
 CD  A1283 (-3.0A)
CL  A1294 (-3.3A)
None
None
 1.34A 4a7tF-5flyA:
undetectable		 4a7tF-5flyA:
20.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5j0g OXIDOREDUCTASE,SUPER
OXIDE DISMUTASE
[CU-ZN]

(Homo sapiens) 		PF00080
(Sod_Cu) 		4 GLU A  39
PRO A  46
LYS A  48
GLU A  88
 None
 0.75A 4a7tF-5j0gA:
13.0		 4a7tF-5j0gA:
56.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jp0 BETA-GLUCOSIDASE
BOGH3B

(Bacteroides
ovatus) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		4 GLU A 529
PRO A 442
TRP A 502
GLU A 505
 None
 1.39A 4a7tF-5jp0A:
3.8		 4a7tF-5jp0A:
12.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kyv LUCIFERIN
4-MONOOXYGENASE

(Photinus
pyralis) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 GLU A 370
LYS A   9
LYS A 372
TRP A 417
 None
 1.38A 4a7tF-5kyvA:
undetectable		 4a7tF-5kyvA:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l3s SIGNAL RECOGNITION
PARTICLE 54 KDA
PROTEIN

(Sulfolobus
solfataricus) 		PF00448
(SRP54)
PF02881
(SRP54_N) 		4 GLU A  53
LYS A  57
LYS A  50
GLU A  77
 None
 1.49A 4a7tF-5l3sA:
undetectable		 4a7tF-5l3sA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tjr METHYLMALONATE-SEMIA
LDEHYDE
DEHYDROGENASE

(Pseudomonas sp.
AAC) 		PF00171
(Aldedh) 		4 GLU A  76
LYS A  72
LYS A 102
GLU A 106
 None
 1.45A 4a7tF-5tjrA:
undetectable		 4a7tF-5tjrA:
16.89