SIMILAR PATTERNS OF AMINO ACIDS FOR 4A7T_A_5FWA1002

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e8t HEMAGGLUTININ-NEURAM
INIDASE


(Avian
avulavirus 1)
PF00423
(HN)
3 ASN A 298
TRP A 295
ASP A 261
None
None
CA  A1001 (-3.6A)
1.26A 4a7tA-1e8tA:
0.0
4a7tF-1e8tA:
0.0
4a7tA-1e8tA:
17.34
4a7tF-1e8tA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ece ENDOCELLULASE E1

(Acidothermus
cellulolyticus)
PF00150
(Cellulase)
3 ASN A  27
TRP A 319
ASP A 158
None
BGC  A 403 ( 4.2A)
None
1.24A 4a7tA-1eceA:
0.0
4a7tF-1eceA:
0.0
4a7tA-1eceA:
17.78
4a7tF-1eceA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gq1 CYTOCHROME CD1
NITRITE REDUCTASE


(Paracoccus
pantotrophus)
PF02239
(Cytochrom_D1)
PF13442
(Cytochrome_CBB3)
3 ASN A 161
TRP A 163
ASP A 224
None
1.30A 4a7tA-1gq1A:
0.0
4a7tF-1gq1A:
0.0
4a7tA-1gq1A:
16.14
4a7tF-1gq1A:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gzj EGI

(Thermoascus
aurantiacus)
PF00150
(Cellulase)
3 ASN A  10
TRP A 273
ASP A 129
None
1.22A 4a7tA-1gzjA:
undetectable
4a7tF-1gzjA:
0.0
4a7tA-1gzjA:
20.88
4a7tF-1gzjA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h3e TYROSYL-TRNA
SYNTHETASE


(Thermus
thermophilus)
PF00579
(tRNA-synt_1b)
3 ASN A 128
TRP A 131
ASP A  45
TYE  A1434 ( 4.8A)
None
TYE  A1434 ( 3.8A)
0.80A 4a7tA-1h3eA:
0.1
4a7tF-1h3eA:
0.2
4a7tA-1h3eA:
16.03
4a7tF-1h3eA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j6x AUTOINDUCER-2
PRODUCTION PROTEIN
LUXS


(Helicobacter
pylori)
PF02664
(LuxS)
3 ASN A 127
TRP A 124
ASP A  50
None
1.30A 4a7tA-1j6xA:
0.0
4a7tF-1j6xA:
0.0
4a7tA-1j6xA:
19.76
4a7tF-1j6xA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jik TYROSYL-TRNA
SYNTHETASE


(Staphylococcus
aureus)
PF00579
(tRNA-synt_1b)
3 ASN A 124
TRP A 127
ASP A  40
545  A 421 (-4.4A)
None
545  A 421 (-3.7A)
0.87A 4a7tA-1jikA:
undetectable
4a7tF-1jikA:
undetectable
4a7tA-1jikA:
16.67
4a7tF-1jikA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k38 BETA-LACTAMASE OXA-2

(Salmonella
enterica)
PF00905
(Transpeptidase)
3 ASN A 231
TRP A 214
ASP A  55
None
1.18A 4a7tA-1k38A:
0.0
4a7tF-1k38A:
0.0
4a7tA-1k38A:
20.70
4a7tF-1k38A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lc7 L-THREONINE-O-3-PHOS
PHATE DECARBOXYLASE


(Salmonella
enterica)
PF00155
(Aminotran_1_2)
3 ASN A 230
TRP A 209
ASP A 233
None
1.18A 4a7tA-1lc7A:
0.0
4a7tF-1lc7A:
0.0
4a7tA-1lc7A:
18.18
4a7tF-1lc7A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qgd PROTEIN
(TRANSKETOLASE)


(Escherichia
coli)
PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C)
3 ASN A   9
TRP A 279
ASP A  35
None
1.19A 4a7tA-1qgdA:
undetectable
4a7tF-1qgdA:
undetectable
4a7tA-1qgdA:
13.31
4a7tF-1qgdA:
13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qgi PROTEIN
(CHITOSANASE)


(Bacillus
circulans)
PF01374
(Glyco_hydro_46)
3 ASN A 227
TRP A 256
ASP A 215
None
1.22A 4a7tA-1qgiA:
undetectable
4a7tF-1qgiA:
undetectable
4a7tA-1qgiA:
22.62
4a7tF-1qgiA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1szn ALPHA-GALACTOSIDASE

(Trichoderma
reesei)
PF16499
(Melibiase_2)
3 ASN A 133
TRP A 205
ASP A 142
GOL  A 901 (-2.9A)
None
GOL  A 901 (-3.7A)
1.12A 4a7tA-1sznA:
undetectable
4a7tF-1sznA:
undetectable
4a7tA-1sznA:
18.47
4a7tF-1sznA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tyd TYROSYL-TRNA
SYNTHETASE


(Geobacillus
stearothermophilus)
PF00579
(tRNA-synt_1b)
3 ASN E 123
TRP E 126
ASP E  38
TYR  E 320 ( 4.7A)
None
TYR  E 320 (-3.6A)
0.85A 4a7tA-1tydE:
undetectable
4a7tF-1tydE:
undetectable
4a7tA-1tydE:
17.61
4a7tF-1tydE:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vbm TYROSYL-TRNA
SYNTHETASE


(Escherichia
coli)
PF00579
(tRNA-synt_1b)
3 ASN A 126
TRP A 129
ASP A  41
YSA  A3001 ( 4.9A)
None
YSA  A3001 (-3.9A)
1.01A 4a7tA-1vbmA:
undetectable
4a7tF-1vbmA:
undetectable
4a7tA-1vbmA:
18.87
4a7tF-1vbmA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2csg PUTATIVE CYTOPLASMIC
PROTEIN


(Salmonella
enterica)
PF07350
(DUF1479)
3 ASN A 113
TRP A 400
ASP A 108
None
1.27A 4a7tA-2csgA:
undetectable
4a7tF-2csgA:
undetectable
4a7tA-2csgA:
20.21
4a7tF-2csgA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e8y AMYX PROTEIN

(Bacillus
subtilis)
PF00128
(Alpha-amylase)
PF02922
(CBM_48)
3 ASN A 399
TRP A 202
ASP A 401
None
0.89A 4a7tA-2e8yA:
undetectable
4a7tF-2e8yA:
3.7
4a7tA-2e8yA:
15.55
4a7tF-2e8yA:
15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hes YDR267CP

(Saccharomyces
cerevisiae)
PF00400
(WD40)
3 ASN X 322
TRP X 324
ASP X 318
None
1.26A 4a7tA-2hesX:
undetectable
4a7tF-2hesX:
undetectable
4a7tA-2hesX:
17.42
4a7tF-2hesX:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2osy ENDOGLYCOCERAMIDASE
II


(Rhodococcus sp.)
PF00150
(Cellulase)
3 ASN A  60
TRP A 382
ASP A 229
None
GLC  A 600 ( 3.5A)
None
1.16A 4a7tA-2osyA:
undetectable
4a7tF-2osyA:
undetectable
4a7tA-2osyA:
14.73
4a7tF-2osyA:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pid TYROSYL-TRNA
SYNTHETASE


(Homo sapiens)
PF00579
(tRNA-synt_1b)
3 ASN A 173
TRP A 176
ASP A  81
YSA  A 384 ( 4.8A)
None
YSA  A 384 (-3.9A)
0.78A 4a7tA-2pidA:
undetectable
4a7tF-2pidA:
undetectable
4a7tA-2pidA:
17.61
4a7tF-2pidA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qp4 BILE SALT
SULFOTRANSFERASE


(Homo sapiens)
PF00685
(Sulfotransfer_1)
3 ASN A 122
TRP A 284
ASP A 253
None
1.15A 4a7tA-2qp4A:
undetectable
4a7tF-2qp4A:
undetectable
4a7tA-2qp4A:
20.38
4a7tF-2qp4A:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ts1 TYROSYL-TRNA
SYNTHETASE


(Geobacillus
stearothermophilus)
PF00579
(tRNA-synt_1b)
3 ASN A 123
TRP A 126
ASP A  38
None
0.91A 4a7tA-2ts1A:
undetectable
4a7tF-2ts1A:
undetectable
4a7tA-2ts1A:
18.44
4a7tF-2ts1A:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vca ALPHA-N-ACETYLGLUCOS
AMINIDASE


(Clostridium
perfringens)
PF00754
(F5_F8_type_C)
PF05089
(NAGLU)
PF12971
(NAGLU_N)
PF12972
(NAGLU_C)
3 ASN A 325
TRP A 321
ASP A 615
None
1.00A 4a7tA-2vcaA:
undetectable
4a7tF-2vcaA:
undetectable
4a7tA-2vcaA:
10.18
4a7tF-2vcaA:
10.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wda PUTATIVE SECRETED
LYASE


(Streptomyces
violaceoruber)
PF02278
(Lyase_8)
PF02884
(Lyase_8_C)
PF08124
(Lyase_8_N)
3 ASN A 557
TRP A 615
ASP A 456
FMT  A1769 (-4.5A)
PEG  A1782 (-3.2A)
FMT  A1769 (-3.5A)
0.99A 4a7tA-2wdaA:
undetectable
4a7tF-2wdaA:
1.2
4a7tA-2wdaA:
12.35
4a7tF-2wdaA:
12.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wkn FORMAMIDASE

(Delftia
acidovorans)
PF03069
(FmdA_AmdA)
3 ASN A  54
TRP A 102
ASP A  56
None
1.13A 4a7tA-2wknA:
undetectable
4a7tF-2wknA:
undetectable
4a7tA-2wknA:
19.12
4a7tF-2wknA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wn4 ADP-RIBOSYLTRANSFERA
SE ENZYMATIC
COMPONENT


(Clostridioides
difficile)
PF03496
(ADPrib_exo_Tox)
3 ASN A 234
TRP A 230
ASP A 237
None
1.13A 4a7tA-2wn4A:
undetectable
4a7tF-2wn4A:
undetectable
4a7tA-2wn4A:
14.29
4a7tF-2wn4A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y9x POLYPHENOL OXIDASE

(Agaricus
bisporus)
PF00264
(Tyrosinase)
3 ASN A 298
TRP A 138
ASP A 367
None
1.06A 4a7tA-2y9xA:
undetectable
4a7tF-2y9xA:
undetectable
4a7tA-2y9xA:
16.45
4a7tF-2y9xA:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3axx 458AA LONG
HYPOTHETICAL
ENDO-1,4-BETA-GLUCAN
ASE


(Pyrococcus
horikoshii)
PF00150
(Cellulase)
3 ASN A  67
TRP A 377
ASP A 197
None
1.22A 4a7tA-3axxA:
undetectable
4a7tF-3axxA:
undetectable
4a7tA-3axxA:
15.85
4a7tF-3axxA:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3djd FRUCTOSYL AMINE:
OXYGEN
OXIDOREDUCTASE


(Aspergillus
fumigatus)
PF01266
(DAO)
3 ASN A 229
TRP A 405
ASP A 226
None
0.89A 4a7tA-3djdA:
undetectable
4a7tF-3djdA:
undetectable
4a7tA-3djdA:
17.21
4a7tF-3djdA:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3efm FERRIC ALCALIGIN
SIDEROPHORE RECEPTOR


(Bordetella
pertussis)
PF00593
(TonB_dep_Rec)
PF07715
(Plug)
3 ASN A 339
TRP A 115
ASP A 311
None
1.21A 4a7tA-3efmA:
undetectable
4a7tF-3efmA:
undetectable
4a7tA-3efmA:
11.72
4a7tF-3efmA:
11.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3flu DIHYDRODIPICOLINATE
SYNTHASE


(Neisseria
meningitidis)
PF00701
(DHDPS)
3 ASN A  34
TRP A  30
ASP A 216
GOL  A 299 (-3.1A)
GOL  A 299 (-4.2A)
None
1.09A 4a7tA-3fluA:
undetectable
4a7tF-3fluA:
undetectable
4a7tA-3fluA:
20.20
4a7tF-3fluA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fot 15-O-ACETYLTRANSFERA
SE


(Fusarium
sporotrichioides)
PF07428
(Tri3)
3 ASN A  46
TRP A  98
ASP A  52
None
1.32A 4a7tA-3fotA:
undetectable
4a7tF-3fotA:
undetectable
4a7tA-3fotA:
16.63
4a7tF-3fotA:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i1l HEMAGGLUTININ-ESTERA
SE PROTEIN


(Porcine
torovirus)
PF02710
(Hema_HEFG)
PF03996
(Hema_esterase)
3 ASN A 128
TRP A 125
ASP A 255
None
0.90A 4a7tA-3i1lA:
undetectable
4a7tF-3i1lA:
undetectable
4a7tA-3i1lA:
18.41
4a7tF-3i1lA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3if6 OXA-46 OXACILLINASE

(Pseudomonas
aeruginosa)
PF00905
(Transpeptidase)
3 ASN C 236
TRP C 219
ASP C  60
None
1.24A 4a7tA-3if6C:
undetectable
4a7tF-3if6C:
undetectable
4a7tA-3if6C:
19.70
4a7tF-3if6C:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iiw POLYCOMB PROTEIN EED

(Homo sapiens)
PF00400
(WD40)
3 ASN A 102
TRP A 152
ASP A 109
None
1.23A 4a7tA-3iiwA:
undetectable
4a7tF-3iiwA:
undetectable
4a7tA-3iiwA:
17.90
4a7tF-3iiwA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jcm U4/U6 SMALL NUCLEAR
RIBONUCLEOPROTEIN
PRP4


(Saccharomyces
cerevisiae)
PF00400
(WD40)
3 ASN B 374
TRP B 376
ASP B 370
None
1.18A 4a7tA-3jcmB:
undetectable
4a7tF-3jcmB:
undetectable
4a7tA-3jcmB:
17.42
4a7tF-3jcmB:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kom TRANSKETOLASE

(Francisella
tularensis)
PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C)
3 ASN A  11
TRP A 281
ASP A  37
None
1.12A 4a7tA-3komA:
undetectable
4a7tF-3komA:
undetectable
4a7tA-3komA:
15.46
4a7tF-3komA:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lew SUSD-LIKE
CARBOHYDRATE BINDING
PROTEIN


(Bacteroides
vulgatus)
PF07980
(SusD_RagB)
PF14322
(SusD-like_3)
3 ASN A 436
TRP A 416
ASP A 162
None
1.20A 4a7tA-3lewA:
undetectable
4a7tF-3lewA:
undetectable
4a7tA-3lewA:
14.32
4a7tF-3lewA:
14.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lm3 UNCHARACTERIZED
PROTEIN


(Parabacteroides
distasonis)
PF12979
(DUF3863)
PF12980
(DUF3864)
3 ASN A 364
TRP A 367
ASP A 236
None
1.31A 4a7tA-3lm3A:
undetectable
4a7tF-3lm3A:
undetectable
4a7tA-3lm3A:
16.11
4a7tF-3lm3A:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oks 4-AMINOBUTYRATE
TRANSAMINASE


(Mycolicibacterium
smegmatis)
PF00202
(Aminotran_3)
3 ASN A 256
TRP A 252
ASP A 222
None
1.19A 4a7tA-3oksA:
undetectable
4a7tF-3oksA:
undetectable
4a7tA-3oksA:
16.74
4a7tF-3oksA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3opy 6-PHOSPHOFRUCTO-1-KI
NASE BETA-SUBUNIT


(Komagataella
pastoris)
PF00365
(PFK)
3 ASN B 197
TRP B 243
ASP B 192
None
1.22A 4a7tA-3opyB:
undetectable
4a7tF-3opyB:
undetectable
4a7tA-3opyB:
11.94
4a7tF-3opyB:
11.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3otn SUSD SUPERFAMILY
PROTEIN


(Parabacteroides
distasonis)
PF07980
(SusD_RagB)
PF14322
(SusD-like_3)
3 ASN A 475
TRP A 476
ASP A 460
None
1.23A 4a7tA-3otnA:
undetectable
4a7tF-3otnA:
undetectable
4a7tA-3otnA:
15.49
4a7tF-3otnA:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r7a PHOSPHOGLYCERATE
MUTASE, PUTATIVE


(Bacillus
anthracis)
PF00300
(His_Phos_1)
3 ASN A  96
TRP A  32
ASP A 140
None
1.26A 4a7tA-3r7aA:
undetectable
4a7tF-3r7aA:
undetectable
4a7tA-3r7aA:
22.86
4a7tF-3r7aA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rsj BONT/F

(Clostridium
botulinum)
PF07951
(Toxin_R_bind_C)
PF07953
(Toxin_R_bind_N)
3 ASN A1108
TRP A1266
ASP A1113
None
1.31A 4a7tA-3rsjA:
undetectable
4a7tF-3rsjA:
undetectable
4a7tA-3rsjA:
14.53
4a7tF-3rsjA:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3th6 TRIOSEPHOSPHATE
ISOMERASE


(Rhipicephalus
microplus)
PF00121
(TIM)
3 ASN A 122
TRP A  90
ASP A 156
None
0.68A 4a7tA-3th6A:
undetectable
4a7tF-3th6A:
undetectable
4a7tA-3th6A:
22.27
4a7tF-3th6A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v10 RHUSIOPATHIAE
SURFACE PROTEIN B


(Erysipelothrix
rhusiopathiae)
PF05737
(Collagen_bind)
3 ASN A 215
TRP A 197
ASP A 247
None
0.74A 4a7tA-3v10A:
undetectable
4a7tF-3v10A:
undetectable
4a7tA-3v10A:
20.50
4a7tF-3v10A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vup BETA-1,4-MANNANASE

(Aplysia kurodai)
PF00150
(Cellulase)
3 ASN A  22
TRP A 322
ASP A 158
None
TRS  A 401 (-3.8A)
None
1.29A 4a7tA-3vupA:
undetectable
4a7tF-3vupA:
undetectable
4a7tA-3vupA:
16.76
4a7tF-3vupA:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vzm ENDO-1,4-BETA-XYLANA
SE


(Bacillus
circulans)
PF00457
(Glyco_hydro_11)
3 ASN A  52
TRP A 185
ASP A 101
None
0.88A 4a7tA-3vzmA:
undetectable
4a7tF-3vzmA:
undetectable
4a7tA-3vzmA:
24.02
4a7tF-3vzmA:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w0k BIFUNCTIONAL
ENDOMANNANASE/ENDOGL
UCANASE


(Caldanaerobius
polysaccharolyticus)
PF00150
(Cellulase)
3 ASN A   7
TRP A 291
ASP A 133
None
TRS  A 401 (-3.6A)
None
1.31A 4a7tA-3w0kA:
undetectable
4a7tF-3w0kA:
undetectable
4a7tA-3w0kA:
18.97
4a7tF-3w0kA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w6m 458AA LONG
HYPOTHETICAL
ENDO-1,4-BETA-GLUCAN
ASE


(Pyrococcus
horikoshii)
PF00150
(Cellulase)
3 ASN A  67
TRP A 377
ASP A 197
None
1.27A 4a7tA-3w6mA:
undetectable
4a7tF-3w6mA:
undetectable
4a7tA-3w6mA:
18.10
4a7tF-3w6mA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wwp (S)-HYDROXYNITRILE
LYASE


(Baliospermum
montanum)
PF00561
(Abhydrolase_1)
3 ASN A 221
TRP A 217
ASP A 111
None
1.18A 4a7tA-3wwpA:
undetectable
4a7tF-3wwpA:
undetectable
4a7tA-3wwpA:
23.08
4a7tF-3wwpA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zyj LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 4C
NETRIN-G1


(Homo sapiens)
PF00053
(Laminin_EGF)
PF00055
(Laminin_N)
PF00560
(LRR_1)
PF07679
(I-set)
PF13306
(LRR_5)
PF13855
(LRR_8)
3 ASN B  84
TRP A 154
ASP A 225
None
1.09A 4a7tA-3zyjB:
undetectable
4a7tF-3zyjB:
undetectable
4a7tA-3zyjB:
16.71
4a7tF-3zyjB:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ee9 ENDOGLUCANASE

(uncultured
bacterium)
PF00150
(Cellulase)
3 ASN A   8
TRP A 276
ASP A 131
None
TRS  A 401 (-3.8A)
None
1.26A 4a7tA-4ee9A:
undetectable
4a7tF-4ee9A:
undetectable
4a7tA-4ee9A:
18.91
4a7tF-4ee9A:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hrt GLOBIN-2 A CHAIN
HEMOGLOBIN B CHAIN


(Scapharca
inaequivalvis)
PF00042
(Globin)
3 ASN A  78
TRP A  22
ASP B  84
None
1.18A 4a7tA-4hrtA:
undetectable
4a7tF-4hrtA:
undetectable
4a7tA-4hrtA:
21.38
4a7tF-4hrtA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jkm BETA-GLUCURONIDASE

(Clostridium
perfringens)
PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
3 ASN A 133
TRP A  65
ASP A 137
None
1.31A 4a7tA-4jkmA:
3.8
4a7tF-4jkmA:
3.2
4a7tA-4jkmA:
14.38
4a7tF-4jkmA:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oud TYROSYL-TRNA
SYNTHETASE


(Escherichia
coli)
PF00579
(tRNA-synt_1b)
3 ASN B 126
TRP B 129
ASP B  41
ASN  B 126 ( 0.6A)
TRP  B 129 ( 0.5A)
ASP  B  41 ( 0.6A)
0.80A 4a7tA-4oudB:
undetectable
4a7tF-4oudB:
undetectable
4a7tA-4oudB:
18.31
4a7tF-4oudB:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p27 VENOM ALLERGEN-LIKE
(VAL) 4 PROTEIN


(Schistosoma
mansoni)
PF00188
(CAP)
3 ASN A 111
TRP A  91
ASP A 144
None
1.27A 4a7tA-4p27A:
undetectable
4a7tF-4p27A:
undetectable
4a7tA-4p27A:
19.89
4a7tF-4p27A:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q9c NOVEL ANTIGEN
RECEPTOR


(Ginglymostoma
cirratum)
PF07654
(C1-set)
3 ASN A 448
TRP A 423
ASP A 389
None
1.16A 4a7tA-4q9cA:
3.8
4a7tF-4q9cA:
3.9
4a7tA-4q9cA:
19.25
4a7tF-4q9cA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qdg PUTATIVE ADHESIN

(Bacteroides
thetaiotaomicron)
PF08842
(Mfa2)
3 ASN A 213
TRP A 156
ASP A 302
None
1.31A 4a7tA-4qdgA:
undetectable
4a7tF-4qdgA:
undetectable
4a7tA-4qdgA:
20.07
4a7tF-4qdgA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tuf MAJOR EXTRACELLULAR
ENDOGLUCANASE


(Xanthomonas
campestris)
PF00150
(Cellulase)
3 ASN A  48
TRP A 337
ASP A 178
None
1.21A 4a7tA-4tufA:
undetectable
4a7tF-4tufA:
undetectable
4a7tA-4tufA:
18.29
4a7tF-4tufA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uac CARBOHYDRATE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, CUT1 FAMILY
(TC 3.A.1.1.-)


([Eubacterium]
rectale)
PF13416
(SBP_bac_8)
3 ASN A 264
TRP A 267
ASP A 243
None
ACR  A 501 (-2.7A)
None
1.19A 4a7tA-4uacA:
undetectable
4a7tF-4uacA:
undetectable
4a7tA-4uacA:
18.39
4a7tF-4uacA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ued EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4E


(Homo sapiens)
PF01652
(IF4E)
3 ASN A  41
TRP A  43
ASP A 147
None
1.27A 4a7tA-4uedA:
undetectable
4a7tF-4uedA:
undetectable
4a7tA-4uedA:
20.77
4a7tF-4uedA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uis GAMMA-SECRETASE

(Homo sapiens)
PF05450
(Nicastrin)
3 ASN A 290
TRP A 289
ASP A 548
None
0.91A 4a7tA-4uisA:
undetectable
4a7tF-4uisA:
undetectable
4a7tA-4uisA:
13.63
4a7tF-4uisA:
13.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uzj NOTUM

(Drosophila
melanogaster)
PF03283
(PAE)
3 ASN A 175
TRP A 119
ASP A  84
None
1.12A 4a7tA-4uzjA:
undetectable
4a7tF-4uzjA:
undetectable
4a7tA-4uzjA:
15.89
4a7tF-4uzjA:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wu0 SIMILAR TO YTER
(BACILUS SUBTILIS)


(Clostridium
acetobutylicum)
PF07470
(Glyco_hydro_88)
3 ASN A  79
TRP A  23
ASP A  32
None
1.18A 4a7tA-4wu0A:
undetectable
4a7tF-4wu0A:
undetectable
4a7tA-4wu0A:
17.65
4a7tF-4wu0A:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xeu TRANSKETOLASE

(Pseudomonas
aeruginosa)
PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C)
3 ASN A   9
TRP A 278
ASP A  35
None
1.14A 4a7tA-4xeuA:
undetectable
4a7tF-4xeuA:
undetectable
4a7tA-4xeuA:
13.44
4a7tF-4xeuA:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xhc ALPHA-L-RHAMNOSIDASE

(Klebsiella
oxytoca)
PF17389
(Bac_rhamnosid6H)
3 ASN A 267
TRP A 226
ASP A 278
None
RAM  A 900 (-3.8A)
None
1.09A 4a7tA-4xhcA:
undetectable
4a7tF-4xhcA:
undetectable
4a7tA-4xhcA:
16.56
4a7tF-4xhcA:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xru PNKP1

(Capnocytophaga
gingivalis)
PF13671
(AAA_33)
3 ASN A  81
TRP A  38
ASP A 106
None
1.23A 4a7tA-4xruA:
undetectable
4a7tF-4xruA:
undetectable
4a7tA-4xruA:
19.68
4a7tF-4xruA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a30 MITOCHONDRIAL
PROTEIN


(Gallus gallus)
PF03828
(PAP_assoc)
3 ASN A 453
TRP A 471
ASP A 394
None
1.23A 4a7tA-5a30A:
undetectable
4a7tF-5a30A:
undetectable
4a7tA-5a30A:
15.56
4a7tF-5a30A:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aby EUKARYOTIC
TRANSLATION
INITIATION FACTOR
4E-3


(Caenorhabditis
elegans)
PF01652
(IF4E)
3 ASN A  36
TRP A  38
ASP A 145
None
1.21A 4a7tA-5abyA:
undetectable
4a7tF-5abyA:
undetectable
4a7tA-5abyA:
20.30
4a7tF-5abyA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aw4 NA, K-ATPASE ALPHA
SUBUNIT


(Squalus
acanthias)
PF00122
(E1-E2_ATPase)
PF00689
(Cation_ATPase_C)
PF00690
(Cation_ATPase_N)
PF13246
(Cation_ATPase)
3 ASN A 395
TRP A 392
ASP A 533
None
1.28A 4a7tA-5aw4A:
undetectable
4a7tF-5aw4A:
undetectable
4a7tA-5aw4A:
9.86
4a7tF-5aw4A:
9.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ei3 EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4E


(Homo sapiens)
PF01652
(IF4E)
3 ASN A  41
TRP A  43
ASP A 147
None
1.27A 4a7tA-5ei3A:
undetectable
4a7tF-5ei3A:
undetectable
4a7tA-5ei3A:
22.27
4a7tF-5ei3A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f7h T-CELL
IMMUNOGLOBULIN AND
MUCIN
DOMAIN-CONTAINING
PROTEIN 4


(Homo sapiens)
no annotation 3 ASN B  29
TRP B  24
ASP B 101
None
None
CA  B 201 ( 3.1A)
1.28A 4a7tA-5f7hB:
undetectable
4a7tF-5f7hB:
undetectable
4a7tA-5f7hB:
22.67
4a7tF-5f7hB:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fbz ENZYME SUBTILASE
SUBHAL FROM BACILLUS
HALMAPALUS


(Bacillus
halmapalus)
PF00082
(Peptidase_S8)
PF04151
(PPC)
3 ASN A 397
TRP A 350
ASP A 218
None
1.31A 4a7tA-5fbzA:
undetectable
4a7tF-5fbzA:
undetectable
4a7tA-5fbzA:
17.66
4a7tF-5fbzA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hvn 3-DEHYDROQUINATE
SYNTHASE


(Francisella
tularensis)
PF01761
(DHQ_synthase)
3 ASN A 202
TRP A 198
ASP A 210
None
1.30A 4a7tA-5hvnA:
undetectable
4a7tF-5hvnA:
undetectable
4a7tA-5hvnA:
16.39
4a7tF-5hvnA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i6s ENDOGLUCANASE

(Talaromyces
verruculosus)
PF00150
(Cellulase)
3 ASN A  19
TRP A 282
ASP A 138
None
1.29A 4a7tA-5i6sA:
undetectable
4a7tF-5i6sA:
undetectable
4a7tA-5i6sA:
20.68
4a7tF-5i6sA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i77 ENDO-BETA-1,
4-GLUCANASE


(Aspergillus
niger)
PF00150
(Cellulase)
3 ASN A  38
TRP A 300
ASP A 156
None
PEG  A 403 ( 4.1A)
None
1.27A 4a7tA-5i77A:
undetectable
4a7tF-5i77A:
undetectable
4a7tA-5i77A:
20.00
4a7tF-5i77A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ihx TYROSINE--TRNA
LIGASE,
MITOCHONDRIAL


(Aspergillus
nidulans)
PF00579
(tRNA-synt_1b)
3 ASN A 227
TRP A 230
ASP A 131
TYR  A 501 ( 4.6A)
None
TYR  A 501 (-2.9A)
0.87A 4a7tA-5ihxA:
undetectable
4a7tF-5ihxA:
undetectable
4a7tA-5ihxA:
17.94
4a7tF-5ihxA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ijx TYROSINE--TRNA
LIGASE,
MITOCHONDRIAL


(Coccidioides
posadasii)
PF00579
(tRNA-synt_1b)
3 ASN A 214
TRP A 217
ASP A 118
TYR  A 501 ( 4.4A)
None
TYR  A 501 (-2.9A)
0.81A 4a7tA-5ijxA:
undetectable
4a7tF-5ijxA:
undetectable
4a7tA-5ijxA:
17.55
4a7tF-5ijxA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5irr SEPTIN-LIKE PROTEIN

(Chlamydomonas
reinhardtii)
PF00735
(Septin)
3 ASN A 204
TRP A 387
ASP A 225
None
0.47A 4a7tA-5irrA:
undetectable
4a7tF-5irrA:
undetectable
4a7tA-5irrA:
18.36
4a7tF-5irrA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j6s ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 2


(Homo sapiens)
PF01433
(Peptidase_M1)
PF11838
(ERAP1_C)
3 ASN A 948
TRP A 944
ASP A 678
None
0.95A 4a7tA-5j6sA:
undetectable
4a7tF-5j6sA:
undetectable
4a7tA-5j6sA:
11.05
4a7tF-5j6sA:
11.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jp6 PUTATIVE
POLYSACCHARIDE
DEACETYLASE


(Bdellovibrio
bacteriovorus)
PF01522
(Polysacc_deac_1)
3 ASN A  37
TRP A  46
ASP A  89
None
1.11A 4a7tA-5jp6A:
undetectable
4a7tF-5jp6A:
undetectable
4a7tA-5jp6A:
19.02
4a7tF-5jp6A:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m6q UNCHARACTERIZED
PROTEIN


(Kutzneria
albida)
PF09017
(Transglut_prok)
3 ASN A  53
TRP A 178
ASP A 226
None
1.23A 4a7tA-5m6qA:
undetectable
4a7tF-5m6qA:
undetectable
4a7tA-5m6qA:
20.18
4a7tF-5m6qA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n6u BETA-MANNOSIDASE

(Dictyoglomus
thermophilum)
PF00703
(Glyco_hydro_2)
PF02837
(Glyco_hydro_2_N)
3 ASN A 476
TRP A 428
ASP A 501
None
1.27A 4a7tA-5n6uA:
5.6
4a7tF-5n6uA:
5.9
4a7tA-5n6uA:
10.67
4a7tF-5n6uA:
10.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t47 EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4E


(Drosophila
melanogaster)
PF01652
(IF4E)
3 ASN A  74
TRP A  76
ASP A 178
None
1.22A 4a7tA-5t47A:
undetectable
4a7tF-5t47A:
undetectable
4a7tA-5t47A:
22.16
4a7tF-5t47A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v1w GLYCOSIDE HYDROLASE

(Bacillus
halodurans)
PF03639
(Glyco_hydro_81)
3 ASN A 440
TRP A 426
ASP A  45
None
0.92A 4a7tA-5v1wA:
undetectable
4a7tF-5v1wA:
undetectable
4a7tA-5v1wA:
11.82
4a7tF-5v1wA:
11.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v1w GLYCOSIDE HYDROLASE

(Bacillus
halodurans)
PF03639
(Glyco_hydro_81)
3 ASN A 540
TRP A 606
ASP A 466
BGC  A 801 (-3.1A)
None
BGC  A 801 ( 2.7A)
1.10A 4a7tA-5v1wA:
undetectable
4a7tF-5v1wA:
undetectable
4a7tA-5v1wA:
11.82
4a7tF-5v1wA:
11.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wh8 PUTATIVE
CARBOHYDRATE-ACTIVE
ENZYME


(uncultured
organism)
no annotation 3 ASN A 198
TRP A 234
ASP A 201
None
1.30A 4a7tA-5wh8A:
undetectable
4a7tF-5wh8A:
undetectable
4a7tA-5wh8A:
19.87
4a7tF-5wh8A:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x62 CARNOSINE
N-METHYLTRANSFERASE


(Saccharomyces
cerevisiae)
PF07942
(N2227)
3 ASN A 302
TRP A 300
ASP A 278
None
1.31A 4a7tA-5x62A:
undetectable
4a7tF-5x62A:
undetectable
4a7tA-5x62A:
18.28
4a7tF-5x62A:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xtb NADH DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR PROTEIN
4, MITOCHONDRIAL
NADH-UBIQUINONE
OXIDOREDUCTASE 75
KDA SUBUNIT,
MITOCHONDRIAL


(Homo sapiens)
PF00384
(Molybdopterin)
PF04800
(ETC_C1_NDUFA4)
PF09326
(NADH_dhqG_C)
PF10588
(NADH-G_4Fe-4S_3)
PF13510
(Fer2_4)
3 ASN L 167
TRP L 166
ASP M 426
None
0.88A 4a7tA-5xtbL:
undetectable
4a7tF-5xtbL:
undetectable
4a7tA-5xtbL:
21.38
4a7tF-5xtbL:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yf0 -

(-)
no annotation 3 ASN A 340
TRP A 338
ASP A 316
None
1.27A 4a7tA-5yf0A:
undetectable
4a7tF-5yf0A:
undetectable
4a7tA-5yf0A:
undetectable
4a7tF-5yf0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yq0 COFJ

(Escherichia
coli)
no annotation 3 ASN A 240
TRP A 244
ASP A  72
None
0.94A 4a7tA-5yq0A:
undetectable
4a7tF-5yq0A:
1.4
4a7tA-5yq0A:
17.29
4a7tF-5yq0A:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b2y SOLUTE-BINDING
PERIPLASMIC PROTEIN
OF IRON/SIDEROPHORE
ABC TRANSPORTER


(Yersinia pestis)
no annotation 3 ASN A 294
TRP A 292
ASP A  49
None
1.11A 4a7tA-6b2yA:
undetectable
4a7tF-6b2yA:
undetectable
4a7tA-6b2yA:
18.73
4a7tF-6b2yA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ba5 INACTIVE
TYROSINE-PROTEIN
KINASE TRANSMEMBRANE
RECEPTOR ROR1
VARIABLE DOMAIN
HEAVY CHAIN,
ANTIBODY R11
VARIABLE DOMAIN OF
LIGHT CHAIN,
ANTIBODY R11


(Homo sapiens)
no annotation 3 ASN A  95
TRP B  57
ASP M 378
None
1.27A 4a7tA-6ba5A:
undetectable
4a7tF-6ba5A:
undetectable
4a7tA-6ba5A:
22.31
4a7tF-6ba5A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bo6 -

(-)
no annotation 3 ASN A 133
TRP A  65
ASP A 137
None
1.27A 4a7tA-6bo6A:
undetectable
4a7tF-6bo6A:
undetectable
4a7tA-6bo6A:
undetectable
4a7tF-6bo6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cwo RIBONUCLEOTIDE
REDUCTASE


(Flavobacterium
johnsoniae)
no annotation 3 ASN A 186
TRP A 190
ASP A  40
None
1.30A 4a7tA-6cwoA:
undetectable
4a7tF-6cwoA:
undetectable
4a7tA-6cwoA:
15.69
4a7tF-6cwoA:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cwp RIBONUCLEOTIDE
REDUCTASE


(Flavobacterium
johnsoniae)
no annotation 3 ASN A 186
TRP A 190
ASP A  40
None
1.26A 4a7tA-6cwpA:
undetectable
4a7tF-6cwpA:
undetectable
4a7tA-6cwpA:
24.75
4a7tF-6cwpA:
24.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f0k FE-S-CLUSTER-CONTAIN
ING HYDROGENASE
POLYSULPHIDE
REDUCTASE NRFD


(Rhodothermus
marinus)
no annotation 3 ASN B 905
TRP C  82
ASP C 406
None
0.85A 4a7tA-6f0kB:
undetectable
4a7tF-6f0kB:
undetectable
4a7tA-6f0kB:
20.65
4a7tF-6f0kB:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fml LES2
RUVB-LIKE HELICASE


(Chaetomium
thermophilum)
no annotation 3 ASN H 452
TRP H 450
ASP D 190
None
1.22A 4a7tA-6fmlH:
undetectable
4a7tF-6fmlH:
undetectable
4a7tA-6fmlH:
17.09
4a7tF-6fmlH:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gh2 LAMINARIBIOSE
PHOSPHORYLASE


(Paenibacillus
sp. YM1)
no annotation 3 ASN A 408
TRP A 373
ASP A 405
None
0.98A 4a7tA-6gh2A:
1.3
4a7tF-6gh2A:
undetectable
4a7tA-6gh2A:
24.16
4a7tF-6gh2A:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6grw -

(-)
no annotation 3 ASN A 140
TRP A 184
ASP A 203
None
0.94A 4a7tA-6grwA:
undetectable
4a7tF-6grwA:
undetectable
4a7tA-6grwA:
undetectable
4a7tF-6grwA:
undetectable