SIMILAR PATTERNS OF AMINO ACIDS FOR 4A7T_A_5FWA1001

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ea9 CYCLOMALTODEXTRINASE

(Bacillus sp.
(in: Bacteria)) 		PF00128
(Alpha-amylase)
PF02903
(Alpha-amylase_N)
PF16657
(Malt_amylase_C) 		3 ASP C 482
LYS C 481
ASP C 480
 None
 0.60A 4a7tA-1ea9C:
2.5		 4a7tA-1ea9C:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g61 TRANSLATION
INITIATION FACTOR 6

(Methanocaldococcus
jannaschii) 		PF01912
(eIF-6) 		3 ASP A2035
LYS A2034
ASP A2036
 None
 0.86A 4a7tA-1g61A:
0.0		 4a7tA-1g61A:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ixp PYRIDOXINE
5'-PHOSPHATE
SYNTHASE

(Escherichia
coli) 		PF03740
(PdxJ) 		3 ASP A 114
LYS A 115
ASP A 118
 None
 0.75A 4a7tA-1ixpA:
undetectable		 4a7tA-1ixpA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l4z STREPTOKINASE

(Streptococcus
dysgalactiae) 		PF02821
(Staphylokinase) 		3 ASP B 120
LYS B 121
ASP B 122
 None
 0.84A 4a7tA-1l4zB:
0.0		 4a7tA-1l4zB:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ldk CULLIN HOMOLOG

(Homo sapiens) 		PF00888
(Cullin)
PF10557
(Cullin_Nedd8) 		3 ASP B 458
LYS B 459
ASP B 460
 None
 0.81A 4a7tA-1ldkB:
undetectable		 4a7tA-1ldkB:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mvu IG VDJ-REGION (HEAVY
CHAIN)

(Mus musculus) 		PF07686
(V-set) 		3 ASP B  31
LYS B  30
ASP B  32
 None
 0.76A 4a7tA-1mvuB:
undetectable		 4a7tA-1mvuB:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n7r HYALURONIDASE

(Streptococcus
pneumoniae) 		PF02278
(Lyase_8)
PF02884
(Lyase_8_C)
PF08124
(Lyase_8_N) 		3 ASP A 431
LYS A 432
ASP A 433
 None
 0.64A 4a7tA-1n7rA:
1.9		 4a7tA-1n7rA:
12.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rxw FLAP
STRUCTURE-SPECIFIC
ENDONUCLEASE

(Archaeoglobus
fulgidus) 		PF00752
(XPG_N)
PF00867
(XPG_I) 		3 ASP A 113
LYS A 114
ASP A 115
 None
 0.77A 4a7tA-1rxwA:
undetectable		 4a7tA-1rxwA:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t8q GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE,
PERIPLASMIC

(Escherichia
coli) 		PF03009
(GDPD) 		3 ASP A 202
LYS A 201
ASP A 203
 None
 0.86A 4a7tA-1t8qA:
0.0		 4a7tA-1t8qA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c1i PEPTIDOGLYCAN GLCNAC
DEACETYLASE

(Streptococcus
pneumoniae) 		PF01522
(Polysacc_deac_1) 		3 ASP A  58
LYS A  57
ASP A  59
 None
 0.82A 4a7tA-2c1iA:
0.0		 4a7tA-2c1iA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dfs MYOSIN-5A

(Gallus gallus) 		PF00063
(Myosin_head)
PF00612
(IQ) 		3 ASP A 740
LYS A 739
ASP A 738
 None
 0.58A 4a7tA-2dfsA:
undetectable		 4a7tA-2dfsA:
8.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dn9 DNAJ HOMOLOG
SUBFAMILY A MEMBER 3

(Homo sapiens) 		PF00226
(DnaJ) 		3 ASP A  42
LYS A  41
ASP A  43
 None
 0.72A 4a7tA-2dn9A:
undetectable		 4a7tA-2dn9A:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eia EIAV CAPSID PROTEIN
P26

(Equine
infectious
anemia virus) 		PF00607
(Gag_p24) 		3 ASP A  75
LYS A  76
ASP A  79
 None
 0.79A 4a7tA-2eiaA:
undetectable		 4a7tA-2eiaA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g8s GLUCOSE/SORBOSONE
DEHYDROGENASES

(Escherichia
coli) 		PF07995
(GSDH) 		3 ASP A 295
LYS A 296
ASP A 297
 None
 0.69A 4a7tA-2g8sA:
undetectable		 4a7tA-2g8sA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2izp PUTATIVE MEMBRANE
ANTIGEN

(Burkholderia
pseudomallei) 		PF06511
(IpaD) 		3 ASP A1176
LYS A1178
ASP A1177
 None
 0.85A 4a7tA-2izpA:
undetectable		 4a7tA-2izpA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jr7 DPH3 HOMOLOG

(Homo sapiens) 		PF05207
(zf-CSL) 		3 ASP A  62
LYS A  61
ASP A  60
 None
 0.69A 4a7tA-2jr7A:
undetectable		 4a7tA-2jr7A:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k7b CALCIUM-BINDING
PROTEIN 1

(Homo sapiens) 		PF13499
(EF-hand_7) 		3 ASP A  39
LYS A  38
ASP A  35
 MG  A 601 (-3.5A)
None
MG  A 601 (-3.3A)
 0.76A 4a7tA-2k7bA:
undetectable		 4a7tA-2k7bA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kct CYTOCHROME C-TYPE
BIOGENESIS PROTEIN
CCME

(Desulfovibrio
vulgaris) 		PF03100
(CcmE) 		3 ASP A  81
LYS A  80
ASP A  79
 None
 0.76A 4a7tA-2kctA:
undetectable		 4a7tA-2kctA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2knx PROLOW-DENSITY
LIPOPROTEIN
RECEPTOR-RELATED
PROTEIN 1

(Homo sapiens) 		PF00057
(Ldl_recept_a) 		3 ASP A  30
LYS A  31
ASP A  32
 None
None
CA  A  51 (-3.8A)
 0.82A 4a7tA-2knxA:
undetectable		 4a7tA-2knxA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kny LRP-1, LINKER, APO-E

(Homo sapiens) 		PF00057
(Ldl_recept_a) 		3 ASP A  30
LYS A  31
ASP A  32
 None
None
CA  A  81 (-3.1A)
 0.73A 4a7tA-2knyA:
undetectable		 4a7tA-2knyA:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lta DE NOVO DESIGNED
PROTEIN

(synthetic
construct) 		PF01515
(PTA_PTB) 		3 ASP A  38
LYS A  37
ASP A  36
 None
 0.79A 4a7tA-2ltaA:
undetectable		 4a7tA-2ltaA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2m3k MINOR PILIN COMP

(Neisseria
meningitidis) 		PF16732
(ComP_DUS) 		3 ASP A  75
LYS A  76
ASP A  77
 None
 0.67A 4a7tA-2m3kA:
undetectable		 4a7tA-2m3kA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mux UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 25

(Homo sapiens) 		PF02809
(UIM) 		3 ASP A  98
LYS A  99
ASP A 101
 None
 0.80A 4a7tA-2muxA:
undetectable		 4a7tA-2muxA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mzj NUCLEOLAR PROTEIN 6

(Saccharomyces
cerevisiae) 		PF00076
(RRM_1) 		3 ASP A  48
LYS A  49
ASP A  46
 None
 0.84A 4a7tA-2mzjA:
undetectable		 4a7tA-2mzjA:
25.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2n2e NISIN IMMUNITY
PROTEIN

(Lactococcus
lactis) 		no annotation 3 ASP A 182
LYS A 181
ASP A 180
 None
 0.72A 4a7tA-2n2eA:
undetectable		 4a7tA-2n2eA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2n80 RHO GDP-DISSOCIATION
INHIBITOR 1

(Homo sapiens) 		PF02115
(Rho_GDI) 		3 ASP B  42
LYS B  43
ASP B  45
 None
 0.72A 4a7tA-2n80B:
3.3		 4a7tA-2n80B:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ogg TREHALOSE OPERON
TRANSCRIPTIONAL
REPRESSOR

(Bacillus
subtilis) 		PF07702
(UTRA) 		3 ASP A 140
LYS A 141
ASP A 142
 None
None
SO4  A 302 ( 4.8A)
 0.84A 4a7tA-2oggA:
undetectable		 4a7tA-2oggA:
24.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2owa ARFGAP-LIKE FINGER
DOMAIN CONTAINING
PROTEIN

(Cryptosporidium
parvum) 		PF01412
(ArfGap) 		3 ASP A  20
LYS A  21
ASP A  24
 None
 0.67A 4a7tA-2owaA:
undetectable		 4a7tA-2owaA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oze ORF DELTA'

(Streptococcus
pyogenes) 		PF13614
(AAA_31) 		3 ASP A  74
LYS A  73
ASP A  72
 None
 0.57A 4a7tA-2ozeA:
undetectable		 4a7tA-2ozeA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ro9 CALMODULIN-2

(Glycine max) 		PF13499
(EF-hand_7) 		3 ASP A  95
LYS A  94
ASP A  93
 CA  A 221 (-4.0A)
None
CA  A 221 (-3.5A)
 0.66A 4a7tA-2ro9A:
undetectable		 4a7tA-2ro9A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2tbv TOMATO BUSHY STUNT
VIRUS

(Tomato bushy
stunt virus) 		PF00729
(Viral_coat) 		3 ASP A 183
LYS A 182
ASP A 181
 CA  A 388 (-3.9A)
None
CA  A 390 (-2.4A)
 0.42A 4a7tA-2tbvA:
undetectable		 4a7tA-2tbvA:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wd6 AGGLUTININ RECEPTOR

(Streptococcus
gordonii) 		PF06696
(Strep_SA_rep)
PF08363
(GbpC) 		3 ASP A 661
LYS A 660
ASP A 659
 None
 0.42A 4a7tA-2wd6A:
1.0		 4a7tA-2wd6A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c2b TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY

(Agrobacterium
fabrum) 		PF00440
(TetR_N) 		3 ASP A 185
LYS A 186
ASP A 187
 None
 0.59A 4a7tA-3c2bA:
undetectable		 4a7tA-3c2bA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ctz XAA-PRO
AMINOPEPTIDASE 1

(Homo sapiens) 		PF00557
(Peptidase_M24)
PF01321
(Creatinase_N)
PF16188
(Peptidase_M24_C)
PF16189
(Creatinase_N_2) 		3 ASP A 579
LYS A 580
ASP A 583
 None
 0.82A 4a7tA-3ctzA:
undetectable		 4a7tA-3ctzA:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dtp MYOSIN REGULATORY
LIGHT CHAIN

(Avicularia
avicularia) 		PF13405
(EF-hand_6)
PF13833
(EF-hand_8) 		3 ASP E  71
LYS E  70
ASP E  69
 None
 0.80A 4a7tA-3dtpE:
undetectable		 4a7tA-3dtpE:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dwk PENICILLIN-BINDING
PROTEIN 2

(Staphylococcus
aureus) 		PF00905
(Transpeptidase)
PF00912
(Transgly) 		3 ASP A 185
LYS A 184
ASP A 186
 SO4  A  16 ( 4.5A)
None
None
 0.82A 4a7tA-3dwkA:
undetectable		 4a7tA-3dwkA:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f9i 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE

(Rickettsia
prowazekii) 		PF13561
(adh_short_C2) 		3 ASP A 101
LYS A 102
ASP A 105
 None
 0.48A 4a7tA-3f9iA:
undetectable		 4a7tA-3f9iA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gas HEME OXYGENASE

(Helicobacter
pylori) 		PF01243
(Putative_PNPOx)
PF10615
(DUF2470) 		3 ASP A 183
LYS A 184
ASP A 187
 None
 0.84A 4a7tA-3gasA:
undetectable		 4a7tA-3gasA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gxk GOOSE-TYPE LYSOZYME
1

(Gadus morhua) 		PF01464
(SLT) 		3 ASP A 172
LYS A 171
ASP A 165
 None
 0.78A 4a7tA-3gxkA:
undetectable		 4a7tA-3gxkA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iu1 GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE 1

(Homo sapiens) 		PF01233
(NMT)
PF02799
(NMT_C) 		3 ASP A 141
LYS A 142
ASP A 143
 None
 0.83A 4a7tA-3iu1A:
undetectable		 4a7tA-3iu1A:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ixw HEMOCYANIN AA6 CHAIN

(Androctonus
australis) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		3 ASP A 284
LYS A 285
ASP A 286
 None
 0.79A 4a7tA-3ixwA:
3.2		 4a7tA-3ixwA:
13.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j7a 40S RIBOSOMAL
PROTEIN US19

(Plasmodium
falciparum) 		PF00203
(Ribosomal_S19) 		3 ASP X  27
LYS X  24
ASP X  23
 None
 0.86A 4a7tA-3j7aX:
undetectable		 4a7tA-3j7aX:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j9o INTRACELLULAR GROWTH
LOCUS PROTEIN B

(Francisella
tularensis) 		PF05943
(VipB) 		3 ASP B  81
LYS B  82
ASP B  85
 None
 0.80A 4a7tA-3j9oB:
undetectable		 4a7tA-3j9oB:
14.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mew SAGA-ASSOCIATED
FACTOR 29 HOMOLOG

(Homo sapiens) 		PF07039
(DUF1325) 		3 ASP A 196
LYS A 200
ASP A 194
 None
 0.80A 4a7tA-3mewA:
undetectable		 4a7tA-3mewA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mj9 JUNCTIONAL ADHESION
MOLECULE-LIKE

(Mus musculus) 		PF07686
(V-set) 		3 ASP A  48
LYS A  46
ASP A  45
 None
 0.81A 4a7tA-3mj9A:
undetectable		 4a7tA-3mj9A:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ob8 BETA-GALACTOSIDASE

(Kluyveromyces
lactis) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF02929
(Bgal_small_N) 		3 ASP A 675
LYS A 674
ASP A 673
 None
 0.78A 4a7tA-3ob8A:
4.5		 4a7tA-3ob8A:
10.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oq0 DBF4

(Saccharomyces
cerevisiae) 		PF08630
(Dfp1_Him1_M) 		3 ASP A 145
LYS A 146
ASP A 149
 None
 0.64A 4a7tA-3oq0A:
undetectable		 4a7tA-3oq0A:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pdw UNCHARACTERIZED
HYDROLASE YUTF

(Bacillus
subtilis) 		PF13242
(Hydrolase_like)
PF13344
(Hydrolase_6) 		3 ASP A 239
LYS A 237
ASP A 240
 None
 0.70A 4a7tA-3pdwA:
undetectable		 4a7tA-3pdwA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3re2 PREDICTED PROTEIN

(Nematostella
vectensis) 		PF05053
(Menin) 		3 ASP A 331
LYS A 330
ASP A 332
 None
 0.61A 4a7tA-3re2A:
undetectable		 4a7tA-3re2A:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ueb PUTATIVE
UNCHARACTERIZED
PROTEIN

(Thermococcus
onnurineus) 		PF11419
(DUF3194) 		3 ASP A  81
LYS A  82
ASP A  85
 None
 0.73A 4a7tA-3uebA:
undetectable		 4a7tA-3uebA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3utn THIOSULFATE
SULFURTRANSFERASE
TUM1

(Saccharomyces
cerevisiae) 		PF00581
(Rhodanese) 		3 ASP X  90
LYS X  89
ASP X  91
 None
 0.86A 4a7tA-3utnX:
undetectable		 4a7tA-3utnX:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aez MITOTIC SPINDLE
CHECKPOINT COMPONENT
MAD2

(Schizosaccharomyces
pombe) 		PF02301
(HORMA) 		3 ASP B 158
LYS B 159
ASP B 160
 None
 0.77A 4a7tA-4aezB:
undetectable		 4a7tA-4aezB:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4awe ENDO-BETA-D-1,4-MANN
ANASE

(Neurospora
sitophila) 		PF00150
(Cellulase) 		3 ASP A 104
LYS A 105
ASP A 108
 None
 0.76A 4a7tA-4aweA:
undetectable		 4a7tA-4aweA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bn7 COPPER INDUCED
NITROREDUCTASE D

(Lactococcus
lactis) 		PF00881
(Nitroreductase) 		3 ASP A  57
LYS A  58
ASP A  61
 None
 0.86A 4a7tA-4bn7A:
undetectable		 4a7tA-4bn7A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c4a PROTEIN ARGININE
N-METHYLTRANSFERASE
7

(Mus musculus) 		PF06325
(PrmA) 		3 ASP A  43
LYS A  42
ASP A  41
 None
 0.55A 4a7tA-4c4aA:
undetectable		 4a7tA-4c4aA:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d4p PROTEIN ATS1,
DIPHTHAMIDE
BIOSYNTHESIS PROTEIN
3

(Saccharomyces
cerevisiae) 		PF00415
(RCC1)
PF05207
(zf-CSL) 		3 ASP A 402
LYS A 403
ASP A 405
 None
 0.83A 4a7tA-4d4pA:
undetectable		 4a7tA-4d4pA:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dcc PUTATIVE HALOACID
DEHALOGENASE-LIKE
HYDROLASE

(Bacteroides
thetaiotaomicron) 		PF13419
(HAD_2) 		3 ASP A  77
LYS A  78
ASP A  81
 None
 0.79A 4a7tA-4dccA:
undetectable		 4a7tA-4dccA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ecg PUTATIVE
IRON-REGULATED
PROTEIN A

(Parabacteroides
distasonis) 		PF09375
(Peptidase_M75) 		3 ASP A 357
LYS A 358
ASP A 361
 None
 0.79A 4a7tA-4ecgA:
undetectable		 4a7tA-4ecgA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4emy AMINOTRANSFERASE
CLASS I AND II

(Anaerococcus
prevotii) 		PF00155
(Aminotran_1_2) 		3 ASP A 213
LYS A 212
ASP A 211
 None
 0.75A 4a7tA-4emyA:
undetectable		 4a7tA-4emyA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fu0 D-ALANINE--D-ALANINE
LIGASE 7

(Enterococcus
faecalis) 		PF01820
(Dala_Dala_lig_N)
PF07478
(Dala_Dala_lig_C) 		3 ASP A 141
LYS A 140
ASP A 139
 None
ADP  A 401 (-2.7A)
None
 0.83A 4a7tA-4fu0A:
undetectable		 4a7tA-4fu0A:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ged ASCORBATE PEROXIDASE

(Leishmania
major) 		PF00141
(peroxidase) 		3 ASP A  74
LYS A  78
ASP A  79
 None
 0.71A 4a7tA-4gedA:
undetectable		 4a7tA-4gedA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iuy SHORT CHAIN
DEHYDROGENASE/REDUCT
ASE

(Acinetobacter
baumannii) 		PF00106
(adh_short) 		3 ASP A 111
LYS A 112
ASP A 115
 None
 0.55A 4a7tA-4iuyA:
undetectable		 4a7tA-4iuyA:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kf7 NUP188

(Thermothelomyces
thermophila) 		PF10487
(Nup188) 		3 ASP A 101
LYS A 100
ASP A 102
 None
 0.74A 4a7tA-4kf7A:
undetectable		 4a7tA-4kf7A:
8.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kh9 HYPOTHETICAL PROTEIN

(Legionella
pneumophila) 		PF16024
(DUF4785) 		3 ASP A 359
LYS A 357
ASP A 360
 None
 0.66A 4a7tA-4kh9A:
3.7		 4a7tA-4kh9A:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l1k D-ALANINE--D-ALANINE
LIGASE

(Xanthomonas
oryzae) 		PF01820
(Dala_Dala_lig_N)
PF07478
(Dala_Dala_lig_C) 		3 ASP A 142
LYS A 141
ASP A 140
 None
ANP  A 401 (-2.6A)
None
 0.79A 4a7tA-4l1kA:
undetectable		 4a7tA-4l1kA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4llf CAPSID PROTEIN

(Cucumber
necrosis virus) 		PF00729
(Viral_coat) 		3 ASP A 175
LYS A 174
ASP A 173
 None
 0.62A 4a7tA-4llfA:
undetectable		 4a7tA-4llfA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pxl CYTOSOLIC ALDEHYDE
DEHYDROGENASE RF2C

(Zea mays) 		PF00171
(Aldedh) 		3 ASP A 349
LYS A 348
ASP A 347
 None
 0.66A 4a7tA-4pxlA:
undetectable		 4a7tA-4pxlA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rcn LONG-CHAIN ACYL-COA
CARBOXYLASE

(Mycobacterium
avium) 		PF00289
(Biotin_carb_N)
PF01039
(Carboxyl_trans)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		3 ASP A 915
LYS A 916
ASP A 919
 None
 0.83A 4a7tA-4rcnA:
undetectable		 4a7tA-4rcnA:
8.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rot ESTERASE A

(Streptococcus
pyogenes) 		PF00756
(Esterase) 		3 ASP A  38
LYS A  37
ASP A  36
 None
 0.68A 4a7tA-4rotA:
undetectable		 4a7tA-4rotA:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uu4 PERIPLASMIC
LIPOPOLYSACCHARIDE
TRANSPORT PROTEIN
LPTH

(Pseudomonas
aeruginosa) 		PF03968
(OstA) 		3 ASP A  98
LYS A  99
ASP A 100
 None
 0.76A 4a7tA-4uu4A:
undetectable		 4a7tA-4uu4A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xct MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9

(Homo sapiens) 		PF00413
(Peptidase_M10) 		3 ASP A 259
LYS A 258
ASP A 260
 None
 0.84A 4a7tA-4xctA:
undetectable		 4a7tA-4xctA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xyw O-ANTIGEN
BIOSYNTHESIS
GLYCOSYLTRANSFERASE
WBNH

(Escherichia
coli) 		PF00534
(Glycos_transf_1)
PF13439
(Glyco_transf_4) 		3 ASP A 303
LYS A 304
ASP A 307
 None
 0.74A 4a7tA-4xywA:
undetectable		 4a7tA-4xywA:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y96 TRIOSEPHOSPHATE
ISOMERASE

(Gemmata
obscuriglobus) 		PF00121
(TIM) 		3 ASP A 204
LYS A 205
ASP A 208
 None
 0.76A 4a7tA-4y96A:
undetectable		 4a7tA-4y96A:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yn2 FUSOLIN

(unidentified
entomopoxvirus) 		PF03067
(LPMO_10) 		3 ASP A  42
LYS A  43
ASP A  46
 None
 0.69A 4a7tA-4yn2A:
2.6		 4a7tA-4yn2A:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aor DOSAGE COMPENSATION
REGULATOR

(Drosophila
melanogaster) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF04408
(HA2)
PF07717
(OB_NTP_bind) 		3 ASP A 603
LYS A 604
ASP A 605
 None
 0.74A 4a7tA-5aorA:
undetectable		 4a7tA-5aorA:
7.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5apz GENERAL CONTROL
PROTEIN GCN4, NOR1
TCAR0761, GENERAL
CONTROL PROTEIN GCN4

(Saccharomyces
cerevisiae;
Thermosinus
carboxydivorans) 		no annotation 3 ASP A  40
LYS A  39
ASP A  41
 None
 0.80A 4a7tA-5apzA:
undetectable		 4a7tA-5apzA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dmy BETA-GALACTOSIDASE

(Bifidobacterium
bifidum) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF16355
(DUF4982) 		3 ASP A 416
LYS A 417
ASP A 418
 None
 0.79A 4a7tA-5dmyA:
4.3		 4a7tA-5dmyA:
10.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fmf TRANSCRIPTION
INITIATION FACTOR
IIE SUBUNIT BETA,
TFA2

(Saccharomyces
cerevisiae) 		PF02186
(TFIIE_beta) 		3 ASP S 212
LYS S 208
ASP S 209
 None
 0.84A 4a7tA-5fmfS:
undetectable		 4a7tA-5fmfS:
24.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5frs SISTER CHROMATID
COHESION PROTEIN
PDS5

(Saccharomyces
cerevisiae) 		PF12717
(Cnd1) 		3 ASP A  53
LYS A  54
ASP A  57
 None
 0.80A 4a7tA-5frsA:
undetectable		 4a7tA-5frsA:
13.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gn1 ATP-DEPENDENT
HELICASE FUN30

(Saccharomyces
cerevisiae) 		PF00176
(SNF2_N)
PF00271
(Helicase_C) 		3 ASP A1017
LYS A1016
ASP A1015
 None
 0.79A 4a7tA-5gn1A:
undetectable		 4a7tA-5gn1A:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h6b PUTATIVE SECRETED
LIPASE

(Streptomyces
sp. W007) 		PF01674
(Lipase_2) 		3 ASP A  92
LYS A  93
ASP A  96
 ZN  A 304 (-3.3A)
None
None
 0.86A 4a7tA-5h6bA:
undetectable		 4a7tA-5h6bA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hn1 INTERLEUKIN-37

(Homo sapiens) 		PF00340
(IL1) 		3 ASP A 125
LYS A 124
ASP A 123
 None
None
SO4  A 302 (-4.5A)
 0.85A 4a7tA-5hn1A:
undetectable		 4a7tA-5hn1A:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hr4 MMEI

(Methylophilus
methylotrophus) 		no annotation 3 ASP C 873
LYS C 874
ASP C 877
 None
 0.63A 4a7tA-5hr4C:
undetectable		 4a7tA-5hr4C:
11.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iva LPS-ASSEMBLY PROTEIN
LPTD

(Pseudomonas
aeruginosa) 		PF04453
(OstA_C) 		3 ASP A 114
LYS A 113
ASP A 112
 None
 0.79A 4a7tA-5ivaA:
undetectable		 4a7tA-5ivaA:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kr6 4-AMINOBUTYRATE
TRANSAMINASE

(Pseudomonas) 		PF00202
(Aminotran_3) 		3 ASP A 392
LYS A 391
ASP A 390
 None
 0.62A 4a7tA-5kr6A:
undetectable		 4a7tA-5kr6A:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ku1 MITOCHONDRIAL RHO
GTPASE 1

(Homo sapiens) 		PF08355
(EF_assoc_1)
PF08356
(EF_assoc_2) 		3 ASP A 296
LYS A 405
ASP A 404
 None
 0.75A 4a7tA-5ku1A:
undetectable		 4a7tA-5ku1A:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lew DNA POLYMERASE III
SUBUNIT ALPHA

(Mycobacterium
tuberculosis) 		no annotation 3 ASP A 822
LYS A 821
ASP A 820
 None
 0.78A 4a7tA-5lewA:
undetectable		 4a7tA-5lewA:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mgt KILLER CELL
LECTIN-LIKE RECEPTOR
SUBFAMILY B MEMBER 1

(Homo sapiens) 		no annotation 3 ASP C 136
LYS C 135
ASP C 134
 None
 0.86A 4a7tA-5mgtC:
undetectable		 4a7tA-5mgtC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n48 NEUTROPHIL
GELATINASE-ASSOCIATE
D LIPOCALIN

(Homo sapiens) 		no annotation 3 ASP A  47
LYS A  46
ASP A  45
 None
 0.79A 4a7tA-5n48A:
undetectable		 4a7tA-5n48A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5opt ACTIVATED PROTEIN
KINASE C RECEPTOR,
PUTATIVE

(Trypanosoma
cruzi) 		no annotation 3 ASP p 217
LYS p 216
ASP p 215
 None
 0.74A 4a7tA-5optp:
undetectable		 4a7tA-5optp:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5szn PROTOCADHERIN GAMMA
A9

(Mus musculus) 		PF00028
(Cadherin)
PF08266
(Cadherin_2) 		3 ASP A 295
LYS A 248
ASP A 240
 CA  A 607 (-3.6A)
None
CA  A 607 (-2.4A)
 0.83A 4a7tA-5sznA:
undetectable		 4a7tA-5sznA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t51 KLLA0F02343P

(Kluyveromyces
lactis) 		PF05859
(Mis12) 		3 ASP A  77
LYS A  78
ASP A  81
 None
 0.49A 4a7tA-5t51A:
undetectable		 4a7tA-5t51A:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5th6 MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9

(Homo sapiens) 		PF00413
(Peptidase_M10)
PF01471
(PG_binding_1) 		3 ASP A 434
LYS A 433
ASP A 435
 None
 0.82A 4a7tA-5th6A:
undetectable		 4a7tA-5th6A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tuk TETRACYCLINE
DESTRUCTASE TET(51)

(uncultured
bacterium) 		PF01494
(FAD_binding_3) 		3 ASP A 168
LYS A 169
ASP A 170
 None
 0.79A 4a7tA-5tukA:
undetectable		 4a7tA-5tukA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wx8 IMMEDIATE-EARLY
PROTEIN 2

(Human
betaherpesvirus
6A) 		PF03361
(Herpes_IE2_3) 		3 ASP A1400
LYS A1399
ASP A1398
 None
 0.76A 4a7tA-5wx8A:
undetectable		 4a7tA-5wx8A:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xoe ATP-DEPENDENT
6-PHOSPHOFRUCTOKINAS
E

(Staphylococcus
aureus) 		no annotation 3 ASP A 153
LYS A 154
ASP A 157
 None
 0.63A 4a7tA-5xoeA:
undetectable		 4a7tA-5xoeA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xxu RIBOSOMAL PROTEIN
US15

(Toxoplasma
gondii) 		PF00312
(Ribosomal_S15)
PF08069
(Ribosomal_S13_N) 		3 ASP N 110
LYS N 109
ASP N 108
 G  2 874 ( 3.9A)
G  2 973 ( 3.4A)
G  2 875 ( 3.0A)
 0.66A 4a7tA-5xxuN:
undetectable		 4a7tA-5xxuN:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ar7 UNCHARACTERIZED
PROTEIN

(Burkholderia
thailandensis) 		PF07007
(LprI) 		3 ASP A  35
LYS A  33
ASP A  38
 None
 0.84A 4a7tA-6ar7A:
undetectable		 4a7tA-6ar7A:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bq8 CGMP-DEPENDENT
PROTEIN KINASE 2

(Homo sapiens) 		no annotation 3 ASP A 308
LYS A 309
ASP A 311
 None
 0.85A 4a7tA-6bq8A:
undetectable		 4a7tA-6bq8A:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fik POLYKETIDE SYNTHASE

(Cercospora
nicotianae) 		no annotation 3 ASP A 634
LYS A 635
ASP A 636
 None
 0.77A 4a7tA-6fikA:
undetectable		 4a7tA-6fikA:
18.47