SIMILAR PATTERNS OF AMINO ACIDS FOR 4A7A_B_RGZB601

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lf9 GLUCOAMYLASE

(Thermoanaerobacterium
thermosaccharolyticum) 		PF00723
(Glyco_hydro_15)
PF09137
(Glucodextran_N) 		5 LEU A 190
LEU A 248
LEU A 133
ILE A  75
PHE A  52
 None
 1.06A 4a7aB-1lf9A:
undetectable		 4a7aB-1lf9A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mt5 FATTY-ACID AMIDE
HYDROLASE

(Rattus
norvegicus) 		PF01425
(Amidase) 		5 PRO A 338
LEU A 364
TYR A 330
PHE A 363
TYR A 454
 None
 1.04A 4a7aB-1mt5A:
0.0		 4a7aB-1mt5A:
19.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1o5w AMINE OXIDASE
[FLAVIN-CONTAINING]
A

(Rattus
norvegicus) 		PF01593
(Amino_oxidase) 		7 PRO A 113
LEU A 176
GLN A 215
ILE A 325
PHE A 352
TYR A 407
TYR A 444
 None
None
MLG  A 709 (-3.8A)
None
None
MLG  A 709 ( 3.8A)
FAD  A 652 ( 4.5A)
 0.84A 4a7aB-1o5wA:
61.2		 4a7aB-1o5wA:
70.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pgw BEAN POD MOTTLE
VIRUS LARGE (L)
SUBUNIT

(Bean pod mottle
virus) 		PF02247
(Como_LCP) 		5 PRO 2 129
LEU 2 141
LEU 2  51
ILE 2  68
ILE 2  72
 None
 1.06A 4a7aB-1pgw2:
undetectable		 4a7aB-1pgw2:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qag UTROPHIN ACTIN
BINDING REGION

(Homo sapiens) 		PF00307
(CH) 		5 LEU A  73
LEU A  70
LEU A  66
ILE A  41
ILE A 130
 None
 0.95A 4a7aB-1qagA:
undetectable		 4a7aB-1qagA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rk2 RIBOKINASE

(Escherichia
coli) 		PF00294
(PfkB) 		5 PRO A 186
LEU A 194
LEU A 173
LEU A 177
ILE A 217
 None
 1.08A 4a7aB-1rk2A:
3.2		 4a7aB-1rk2A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tdj BIOSYNTHETIC
THREONINE DEAMINASE

(Escherichia
coli) 		PF00291
(PALP)
PF00585
(Thr_dehydrat_C) 		5 PRO A 186
LEU A 192
LEU A 169
LEU A 173
ILE A 313
 None
PLP  A 962 (-4.5A)
None
None
None
 1.04A 4a7aB-1tdjA:
undetectable		 4a7aB-1tdjA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v2d GLUTAMINE
AMINOTRANSFERASE

(Thermus
thermophilus) 		PF00155
(Aminotran_1_2) 		5 LEU A  98
LEU A  95
LEU A  91
ILE A 234
ILE A 189
 None
 1.09A 4a7aB-1v2dA:
undetectable		 4a7aB-1v2dA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vpv UPF0230 PROTEIN
TM1468

(Thermotoga
maritima) 		PF02645
(DegV) 		5 LEU A 247
LEU A 246
LEU A 216
ILE A 281
TYR A 203
 None
 1.14A 4a7aB-1vpvA:
undetectable		 4a7aB-1vpvA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w1k VANILLYL-ALCOHOL
OXIDASE

(Penicillium
simplicissimum) 		PF01565
(FAD_binding_4)
PF02913
(FAD-oxidase_C) 		5 PRO A  77
LEU A 121
LEU A  97
ILE A  86
PHE A  93
 None
 1.08A 4a7aB-1w1kA:
undetectable		 4a7aB-1w1kA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w8d 2,4-DIENOYL-COA
REDUCTASE,
MITOCHONDRIAL
PRECURSOR

(Homo sapiens) 		PF13561
(adh_short_C2) 		5 PRO A 240
LEU A 277
LEU A 280
LEU A 284
CYH A 285
 NAP  A1330 (-4.5A)
None
None
None
None
 1.08A 4a7aB-1w8dA:
3.4		 4a7aB-1w8dA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wwl MONOCYTE
DIFFERENTIATION
ANTIGEN CD14

(Mus musculus) 		no annotation 5 PRO A 298
LEU A 281
LEU A 262
LEU A 267
GLN A 269
 None
 1.05A 4a7aB-1wwlA:
undetectable		 4a7aB-1wwlA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zvd SMAD UBIQUITINATION
REGULATORY FACTOR 2

(Homo sapiens) 		PF00632
(HECT) 		5 LEU A 442
LEU A 445
ILE A 500
ILE A 489
TYR A 459
 None
 1.14A 4a7aB-1zvdA:
undetectable		 4a7aB-1zvdA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ap1 PUTATIVE REGULATOR
PROTEIN

(Salmonella
enterica) 		PF00480
(ROK) 		5 LEU A 230
LEU A 233
LEU A 237
ILE A 282
PHE A 155
 None
 1.13A 4a7aB-2ap1A:
undetectable		 4a7aB-2ap1A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1

(Homo sapiens) 		PF00330
(Aconitase)
PF00694
(Aconitase_C) 		5 PRO A 171
GLN A 179
ILE A 616
TYR A 613
PHE A 609
 None
 0.99A 4a7aB-2b3xA:
undetectable		 4a7aB-2b3xA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bih NITRATE REDUCTASE
[NADPH]

(Ogataea angusta) 		PF00174
(Oxidored_molyb)
PF03404
(Mo-co_dimer) 		5 LEU A 237
LEU A 253
LEU A 256
ILE A 119
ILE A 220
 None
 1.13A 4a7aB-2bihA:
undetectable		 4a7aB-2bihA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2buf ACETYLGLUTAMATE
KINASE

(Pseudomonas
aeruginosa) 		PF00696
(AA_kinase) 		5 LEU A 223
LEU A 231
ILE A 295
GLN A 238
ILE A 248
 None
 1.12A 4a7aB-2bufA:
undetectable		 4a7aB-2bufA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f06 CONSERVED
HYPOTHETICAL PROTEIN

(Bacteroides
thetaiotaomicron) 		no annotation 5 LEU A  90
LEU A  87
LEU A  83
ILE A  74
ILE A  97
 None
None
HIS  A 152 (-3.7A)
None
None
 0.95A 4a7aB-2f06A:
undetectable		 4a7aB-2f06A:
15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 364
LEU A 428
LEU A 429
ILE A 489
ILE A 347
 None
 1.07A 4a7aB-2hz0A:
undetectable		 4a7aB-2hz0A:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i3f GLYCOLIPID
TRANSFER-LIKE
PROTEIN

(Galdieria
sulphuraria) 		PF08718
(GLTP) 		5 PRO A 153
LEU A 121
LEU A 114
LEU A 111
PHE A 176
 None
 1.14A 4a7aB-2i3fA:
undetectable		 4a7aB-2i3fA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i79 ACETYLTRANSFERASE,
GNAT FAMILY

(Streptococcus
pneumoniae) 		PF00583
(Acetyltransf_1) 		6 LEU A 107
LEU A 103
LEU A  66
ILE A  70
ILE A  94
TYR A  98
 None
ACO  A 402 (-4.9A)
None
None
ACO  A 402 (-4.1A)
None
 1.49A 4a7aB-2i79A:
undetectable		 4a7aB-2i79A:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2in3 HYPOTHETICAL PROTEIN

(Nitrosomonas
europaea) 		PF01323
(DSBA) 		5 LEU A 178
LEU A   8
ILE A  29
TYR A  33
PHE A  36
 None
 1.06A 4a7aB-2in3A:
undetectable		 4a7aB-2in3A:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j7n RNA-DEPENDENT RNA
POLYMERASE

(Neurospora
crassa) 		PF05183
(RdRP) 		5 PRO A 732
LEU A 728
LEU A 726
GLN A 736
ILE A 722
 None
 1.11A 4a7aB-2j7nA:
undetectable		 4a7aB-2j7nA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2n9u RESPONSE REGULATOR

(Erythrobacter
litoralis) 		PF00072
(Response_reg) 		5 LEU A 192
LEU A 158
LEU A 161
ILE A 253
ILE A 221
 None
 1.11A 4a7aB-2n9uA:
undetectable		 4a7aB-2n9uA:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2okx RHAMNOSIDASE B

(Bacillus sp.
GL1) 		PF05592
(Bac_rhamnosid)
PF08531
(Bac_rhamnosid_N)
PF17389
(Bac_rhamnosid6H)
PF17390
(Bac_rhamnosid_C) 		5 PRO A 868
LEU A 872
LEU A 546
LEU A 545
ILE A 824
 None
 1.12A 4a7aB-2okxA:
undetectable		 4a7aB-2okxA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qgh DIAMINOPIMELATE
DECARBOXYLASE

(Helicobacter
pylori) 		PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N) 		5 PRO A 179
LEU A 169
LEU A 165
ILE A 134
ILE A 215
 None
 0.92A 4a7aB-2qghA:
undetectable		 4a7aB-2qghA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r39 FIXG-RELATED PROTEIN

(Vibrio
parahaemolyticus) 		PF11614
(FixG_C) 		5 LEU A 446
LEU A 420
LEU A 468
ILE A 436
TYR A 418
 None
 1.02A 4a7aB-2r39A:
undetectable		 4a7aB-2r39A:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rk0 GLYOXALASE/BLEOMYCIN
RESISTANCE
PROTEIN/DIOXYGENASE
DOMAIN

(Frankia sp.
EAN1pec) 		PF00903
(Glyoxalase) 		5 LEU A  51
LEU A  47
LEU A  27
ILE A  53
TYR A  23
 None
 1.00A 4a7aB-2rk0A:
undetectable		 4a7aB-2rk0A:
13.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vl6 MINICHROMOSOME
MAINTENANCE PROTEIN
MCM

(Sulfolobus
solfataricus) 		PF14551
(MCM_N)
PF17207
(MCM_OB) 		5 LEU A  37
ILE A  93
ILE A  82
TYR A  79
TYR A 138
 None
 1.11A 4a7aB-2vl6A:
undetectable		 4a7aB-2vl6A:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w0s THYMIDYLATE KINASE

(Vaccinia virus) 		PF02223
(Thymidylate_kin) 		5 PRO A 120
LEU A   6
LEU A  89
LEU A  36
ILE A  79
 None
 1.00A 4a7aB-2w0sA:
undetectable		 4a7aB-2w0sA:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wmh FUCOLECTIN-RELATED
PROTEIN

(Streptococcus
pneumoniae) 		PF08306
(Glyco_hydro_98M)
PF08307
(Glyco_hydro_98C) 		5 LEU A 468
LEU A 466
LEU A 543
ILE A 577
ILE A 487
 None
 1.12A 4a7aB-2wmhA:
undetectable		 4a7aB-2wmhA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xko GLOBAL NITROGEN
REGULATOR

(Synechococcus
elongatus) 		PF00027
(cNMP_binding)
PF13545
(HTH_Crp_2) 		5 LEU A 148
LEU A 155
CYH A 156
ILE A 209
ILE A 178
 None
 0.79A 4a7aB-2xkoA:
undetectable		 4a7aB-2xkoA:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xot AMPHOTERIN-INDUCED
PROTEIN 1

(Mus musculus) 		PF07679
(I-set)
PF13855
(LRR_8) 		5 PRO A 174
LEU A 190
LEU A 163
LEU A 141
ILE A 170
 None
 1.06A 4a7aB-2xotA:
undetectable		 4a7aB-2xotA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y0n MALE-SPECIFIC LETHAL
1 HOMOLOG
MALE-SPECIFIC LETHAL
3 HOMOLOG

(Homo sapiens;
Mus musculus) 		PF05712
(MRG)
no annotation 		5 PRO E 582
LEU E 584
LEU A 459
ILE A 466
PHE A 460
 None
 1.14A 4a7aB-2y0nE:
undetectable		 4a7aB-2y0nE:
7.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2z5x AMINE OXIDASE
[FLAVIN-CONTAINING]
A

(Homo sapiens) 		PF01593
(Amino_oxidase) 		7 PRO A 113
LEU A 176
GLN A 215
ILE A 325
PHE A 352
TYR A 407
TYR A 444
 None
None
HRM  A 700 (-3.4A)
None
HRM  A 700 (-4.3A)
HRM  A 700 ( 3.9A)
FAD  A 600 ( 4.6A)
 0.48A 4a7aB-2z5xA:
62.1		 4a7aB-2z5xA:
72.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z7x TOLL-LIKE RECEPTOR
1, VARIABLE
LYMPHOCYTE RECEPTOR
B

(Eptatretus
burgeri;
Homo sapiens) 		PF11921
(DUF3439)
PF13855
(LRR_8) 		5 LEU B  95
LEU B  71
LEU B  50
ILE B  76
ILE B  65
 None
 1.14A 4a7aB-2z7xB:
undetectable		 4a7aB-2z7xB:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z87 CHONDROITIN SYNTHASE

(Escherichia
coli) 		PF00535
(Glycos_transf_2) 		5 LEU A 165
LEU A 172
CYH A 173
ILE A 207
ILE A 156
 None
 0.90A 4a7aB-2z87A:
undetectable		 4a7aB-2z87A:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c49 POLY(ADP-RIBOSE)
POLYMERASE 3

(Homo sapiens) 		PF00644
(PARP)
PF02877
(PARP_reg) 		5 LEU A 322
LEU A 395
LEU A 528
ILE A 196
TYR A 438
 None
 1.14A 4a7aB-3c49A:
undetectable		 4a7aB-3c49A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dy5 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN

(Plexaura
homomalla) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		5 LEU A 935
LEU A 932
LEU A 928
ILE A 899
GLN A 896
 None
 0.77A 4a7aB-3dy5A:
undetectable		 4a7aB-3dy5A:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eaa EVPC

(Edwardsiella
tarda) 		PF05638
(T6SS_HCP) 		5 LEU A   9
LEU A  83
LEU A  57
ILE A 126
ILE A   7
 None
 1.05A 4a7aB-3eaaA:
undetectable		 4a7aB-3eaaA:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3euh CHROMOSOME PARTITION
PROTEIN MUKF

(Escherichia
coli) 		PF03882
(KicB)
PF17192
(MukF_M)
PF17193
(MukF_C) 		5 LEU A  86
LEU A  32
LEU A  29
ILE A 110
TYR A 114
 None
 1.14A 4a7aB-3euhA:
undetectable		 4a7aB-3euhA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fg4 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN

(Plexaura
homomalla) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		5 LEU A 935
LEU A 932
LEU A 928
ILE A 899
GLN A 896
 None
 0.79A 4a7aB-3fg4A:
undetectable		 4a7aB-3fg4A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gka N-ETHYLMALEIMIDE
REDUCTASE

(Burkholderia
pseudomallei) 		PF00724
(Oxidored_FMN) 		5 PRO A 289
LEU A  16
LEU A  23
ILE A 291
ILE A  18
 None
 0.99A 4a7aB-3gkaA:
undetectable		 4a7aB-3gkaA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gka N-ETHYLMALEIMIDE
REDUCTASE

(Burkholderia
pseudomallei) 		PF00724
(Oxidored_FMN) 		5 PRO A 289
LEU A  16
LEU A  23
LEU A  59
ILE A 291
 None
 0.98A 4a7aB-3gkaA:
undetectable		 4a7aB-3gkaA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h7t GROUP 3 ALLERGEN
SMIPP-S YVT004A06

(Sarcoptes
scabiei) 		PF00089
(Trypsin) 		5 LEU A 196
LEU A 215
ILE A  37
TYR A  86
TYR A 166
 None
 1.08A 4a7aB-3h7tA:
undetectable		 4a7aB-3h7tA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hdi PROCESSING PROTEASE

(Bacillus
halodurans) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C) 		5 LEU A 269
LEU A 261
LEU A 392
ILE A 298
TYR A 241
 None
 1.13A 4a7aB-3hdiA:
undetectable		 4a7aB-3hdiA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3imf SHORT CHAIN
DEHYDROGENASE

(Bacillus
anthracis) 		PF13561
(adh_short_C2) 		5 LEU A 224
LEU A 228
CYH A 229
ILE A  85
ILE A 182
 None
 1.09A 4a7aB-3imfA:
3.4		 4a7aB-3imfA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k9h PF-32 PROTEIN

(Borreliella
burgdorferi) 		PF13614
(AAA_31) 		5 LEU A 120
LEU A 117
LEU A 113
ILE A  92
ILE A 127
 None
 0.99A 4a7aB-3k9hA:
undetectable		 4a7aB-3k9hA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kcn ADENYLATE CYCLASE
HOMOLOG

(Rhodopirellula
baltica) 		PF00072
(Response_reg) 		5 LEU A  11
LEU A  82
ILE A 115
ILE A   9
PHE A 103
 None
 0.85A 4a7aB-3kcnA:
undetectable		 4a7aB-3kcnA:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l07 BIFUNCTIONAL PROTEIN
FOLD

(Francisella
tularensis) 		PF00763
(THF_DHG_CYH)
PF02882
(THF_DHG_CYH_C) 		5 LEU A  77
LEU A  80
LEU A  84
ILE A 112
ILE A  37
 None
 1.03A 4a7aB-3l07A:
undetectable		 4a7aB-3l07A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3la2 GLOBAL NITROGEN
REGULATOR

(Nostoc sp. PCC
7120) 		PF00027
(cNMP_binding)
PF13545
(HTH_Crp_2) 		5 LEU A 149
LEU A 156
CYH A 157
ILE A 210
ILE A 179
 None
 0.83A 4a7aB-3la2A:
undetectable		 4a7aB-3la2A:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lup DEGV FAMILY PROTEIN

(Streptococcus
agalactiae) 		PF02645
(DegV) 		5 LEU A  69
LEU A  72
LEU A  76
ILE A 112
ILE A   6
 None
GOL  A 302 ( 4.2A)
None
None
None
 0.97A 4a7aB-3lupA:
undetectable		 4a7aB-3lupA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3odm PHOSPHOENOLPYRUVATE
CARBOXYLASE

(Clostridium
perfringens) 		PF14010
(PEPcase_2) 		5 LEU A 429
LEU A 436
LEU A 440
ILE A 210
TYR A 481
 None
 0.92A 4a7aB-3odmA:
undetectable		 4a7aB-3odmA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ogk CORONATINE-INSENSITI
VE PROTEIN 1

(Arabidopsis
thaliana) 		no annotation 5 LEU B 132
LEU B 129
CYH B 148
ILE B 159
PHE B 176
 None
 1.03A 4a7aB-3ogkB:
undetectable		 4a7aB-3ogkB:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ppc 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE

(Candida
albicans) 		PF01717
(Meth_synt_2)
PF08267
(Meth_synt_1) 		5 PRO A 150
LEU A 207
LEU A 204
ILE A 168
TYR A 200
 None
 1.13A 4a7aB-3ppcA:
undetectable		 4a7aB-3ppcA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qhq SAG0897 FAMILY
CRISPR-ASSOCIATED
PROTEIN

(Streptococcus
agalactiae) 		PF09711
(Cas_Csn2) 		5 LEU A  45
LEU A  47
LEU A 164
ILE A   4
TYR A 156
 None
 0.90A 4a7aB-3qhqA:
undetectable		 4a7aB-3qhqA:
18.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zyx AMINE OXIDASE
[FLAVIN-CONTAINING]
B

(Homo sapiens) 		PF01593
(Amino_oxidase) 		10 PRO A 104
LEU A 164
LEU A 167
LEU A 171
CYH A 172
GLN A 206
ILE A 316
PHE A 343
TYR A 398
TYR A 435
 None
None
None
MBT  A 601 (-4.2A)
None
MBT  A 601 (-3.4A)
MBT  A 601 (-4.6A)
MBT  A 601 (-4.7A)
MBT  A 601 ( 3.6A)
MBT  A 601 ( 4.6A)
 0.42A 4a7aB-3zyxA:
64.9		 4a7aB-3zyxA:
99.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a7l MYOSIN IE HEAVY
CHAIN

(Dictyostelium
discoideum) 		PF00063
(Myosin_head) 		5 LEU C 577
LEU C 413
LEU C 410
CYH C 406
ILE C  98
 None
 1.13A 4a7aB-4a7lC:
undetectable		 4a7aB-4a7lC:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ae5 SIGNAL TRANSDUCTION
PROTEIN TRAP

(Staphylococcus
aureus) 		no annotation 5 PRO A 108
LEU A  83
LEU A  87
ILE A  56
PHE A 139
 None
 1.05A 4a7aB-4ae5A:
undetectable		 4a7aB-4ae5A:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4co6 NUCLEOPROTEIN

(Nipah
henipavirus) 		PF00973
(Paramyxo_ncap) 		5 LEU A 221
LEU A 175
LEU A 214
ILE A  59
ILE A 172
 None
 1.07A 4a7aB-4co6A:
undetectable		 4a7aB-4co6A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e2s UREIDOGLYCINE
AMINOHYDROLASE

(Arabidopsis
thaliana) 		PF07883
(Cupin_2) 		5 LEU A 210
LEU A 209
ILE A 187
TYR A 150
PHE A 127
 None
 1.13A 4a7aB-4e2sA:
undetectable		 4a7aB-4e2sA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e4y SHORT CHAIN
DEHYDROGENASE FAMILY
PROTEIN

(Francisella
tularensis) 		PF13561
(adh_short_C2) 		5 LEU A 109
LEU A   5
ILE A  56
ILE A  63
PHE A  45
 None
 1.14A 4a7aB-4e4yA:
2.7		 4a7aB-4e4yA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ehj PHOSPHOGLYCERATE
KINASE

(Francisella
tularensis) 		PF00162
(PGK) 		5 PRO A 257
LEU A 302
LEU A 303
LEU A 330
ILE A 212
 None
 1.12A 4a7aB-4ehjA:
undetectable		 4a7aB-4ehjA:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g41 MTA/SAH NUCLEOSIDASE

(Streptococcus
pyogenes) 		PF01048
(PNP_UDP_1) 		5 LEU A 229
LEU A 226
LEU A 222
ILE A 190
ILE A   3
 LEU  A 229 ( 0.6A)
LEU  A 226 ( 0.6A)
LEU  A 222 ( 0.6A)
ILE  A 190 ( 0.7A)
ILE  A   3 ( 0.6A)
 0.81A 4a7aB-4g41A:
undetectable		 4a7aB-4g41A:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h09 HYPOTHETICAL LEUCINE
RICH REPEAT PROTEIN

(Eubacterium
ventriosum) 		PF13306
(LRR_5) 		5 LEU A 290
LEU A 289
ILE A 253
ILE A 278
TYR A 211
 None
 1.13A 4a7aB-4h09A:
undetectable		 4a7aB-4h09A:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i3g BETA-GLUCOSIDASE

(Streptomyces
venezuelae) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		5 LEU A 543
LEU A 541
ILE A 504
ILE A 529
PHE A 532
 None
 1.09A 4a7aB-4i3gA:
undetectable		 4a7aB-4i3gA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iug BETA-GALACTOSIDASE A

(Aspergillus
oryzae) 		PF01301
(Glyco_hydro_35)
PF10435
(BetaGal_dom2)
PF13363
(BetaGal_dom3)
PF13364
(BetaGal_dom4_5) 		5 LEU A 560
LEU A 503
LEU A 505
ILE A 544
ILE A 484
 None
 0.94A 4a7aB-4iugA:
undetectable		 4a7aB-4iugA:
19.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4krf PROTEIN ARGONAUTE-1

(Homo sapiens) 		PF02170
(PAZ)
PF02171
(Piwi)
PF08699
(ArgoL1)
PF16486
(ArgoN)
PF16487
(ArgoMid)
PF16488
(ArgoL2) 		5 LEU A 777
LEU A 780
LEU A 784
CYH A 785
ILE A 663
 None
 0.80A 4a7aB-4krfA:
undetectable		 4a7aB-4krfA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oj5 TAILSPIKE PROTEIN

(Escherichia
virus CBA120) 		no annotation 5 LEU A 272
LEU A 331
LEU A 354
ILE A 256
ILE A 284
 None
 1.15A 4a7aB-4oj5A:
undetectable		 4a7aB-4oj5A:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pue ENDO-1,4-BETA-XYLANA
SE

(Geobacillus
stearothermophilus) 		PF00331
(Glyco_hydro_10) 		5 LEU A 299
LEU A 302
LEU A 306
ILE A 263
ILE A 247
 None
 1.13A 4a7aB-4pueA:
undetectable		 4a7aB-4pueA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r94 NON-STRUCTURAL
PROTEIN NS1

(Rodent
protoparvovirus
1) 		PF12433
(PV_NSP1) 		5 LEU A 165
LEU A 173
LEU A 157
GLN A  86
ILE A  42
 None
 1.14A 4a7aB-4r94A:
undetectable		 4a7aB-4r94A:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4trq NUCLEAR MRNA EXPORT
PROTEIN SAC3
NUCLEAR MRNA EXPORT
PROTEIN THP1

(Saccharomyces
cerevisiae) 		PF01399
(PCI)
PF03399
(SAC3_GANP) 		6 PRO B 419
LEU A 465
LEU A 508
LEU A 458
ILE A 472
PHE A 492
 None
 1.16A 4a7aB-4trqB:
undetectable		 4a7aB-4trqB:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ubt ACETYL-COA
ACETYLTRANSFERASE
FADA5

(Mycobacterium
tuberculosis) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		5 PRO A  13
LEU A  21
LEU A  24
GLN A  34
ILE A 196
 None
 1.06A 4a7aB-4ubtA:
undetectable		 4a7aB-4ubtA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uvk ZYRO0D15994P

(Zygosaccharomyces
rouxii) 		PF08514
(STAG) 		5 LEU A 247
LEU A 250
LEU A 258
ILE A 142
PHE A 177
 None
 1.14A 4a7aB-4uvkA:
undetectable		 4a7aB-4uvkA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wlh KYNURENINE--OXOGLUTA
RATE TRANSAMINASE 1

(Homo sapiens) 		PF00155
(Aminotran_1_2) 		5 LEU A 162
LEU A 198
LEU A 202
CYH A 203
ILE A 119
 None
 1.10A 4a7aB-4wlhA:
undetectable		 4a7aB-4wlhA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xpz RNA POLYMERASE II
SUBUNIT A C-TERMINAL
DOMAIN PHOSPHATASE

(Schizosaccharomyces
pombe) 		PF03031
(NIF)
PF12738
(PTCB-BRCT) 		5 LEU A 497
LEU A 500
LEU A 504
ILE A 451
PHE A 458
 None
 1.08A 4a7aB-4xpzA:
undetectable		 4a7aB-4xpzA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xqe HOMOSPERMIDINE
SYNTHASE

(Blastochloris
viridis) 		PF03435
(Sacchrp_dh_NADP)
PF16653
(Sacchrp_dh_C) 		5 LEU A  74
LEU A  78
CYH A  88
ILE A  17
ILE A  62
 None
None
None
NAD  A 501 ( 4.3A)
None
 1.11A 4a7aB-4xqeA:
1.9		 4a7aB-4xqeA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z94 GELSOLIN,
TROPOMODULIN-1,
LEIOMODIN-1 CHIMERA

(Homo sapiens) 		PF00626
(Gelsolin) 		5 LEU G1366
LEU G1394
LEU G1420
ILE G1389
ILE G1379
 None
 1.11A 4a7aB-4z94G:
undetectable		 4a7aB-4z94G:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b4x REELIN

(Mus musculus) 		PF07974
(EGF_2) 		5 LEU A2431
LEU A2398
ILE A2442
PHE A2457
TYR A2449
 None
 1.06A 4a7aB-5b4xA:
undetectable		 4a7aB-5b4xA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cio PYRROLOQUINOLINE
QUINONE BIOSYNTHESIS
PROTEIN PQQF

(Serratia sp.
FS14) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C) 		5 PRO A 454
LEU A 583
LEU A 587
ILE A 512
PHE A 594
 None
 0.98A 4a7aB-5cioA:
undetectable		 4a7aB-5cioA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d2e MLNE

(Bacillus
velezensis) 		PF08659
(KR) 		5 LEU A 114
LEU A 118
CYH A 168
ILE A 128
ILE A  85
 None
 1.12A 4a7aB-5d2eA:
undetectable		 4a7aB-5d2eA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e1t TNF
RECEPTOR-ASSOCIATED
FACTOR 1

(Homo sapiens) 		no annotation 5 LEU A 291
LEU A 309
LEU A 322
ILE A 273
PHE A 388
 None
 0.89A 4a7aB-5e1tA:
undetectable		 4a7aB-5e1tA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ehk LANTIBIOTIC
DEHYDRATASE

(Microbispora
corallina) 		PF04738
(Lant_dehydr_N)
PF14028
(Lant_dehydr_C) 		5 PRO A 634
LEU A 623
LEU A 426
LEU A 609
ILE A 607
 None
 1.12A 4a7aB-5ehkA:
undetectable		 4a7aB-5ehkA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g5g PUTATIVE XANTHINE
DEHYDROGENASE YAGR
MOLYBDENUM-BINDING
SU SUBUNIT
PUTATIVE XANTHINE
DEHYDROGENASE YAGT
IRON-SULFUR-BINDING
SUBUNIT

(Escherichia
coli) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01799
(Fer2_2)
PF03450
(CO_deh_flav_C) 		5 LEU A  86
LEU A  82
GLN A 127
ILE A 131
TYR B   6
 None
 1.04A 4a7aB-5g5gA:
undetectable		 4a7aB-5g5gA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ghe PESTICIDAL CRYSTAL
PROTEIN CRY6AA

(Bacillus
thuringiensis) 		no annotation 5 LEU A 183
LEU A 101
ILE A  47
ILE A 105
TYR A 102
 None
 1.15A 4a7aB-5gheA:
undetectable		 4a7aB-5gheA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jxr CHROMATIN-REMODELING
COMPLEX ATPASE-LIKE
PROTEIN

(Thermothelomyces
thermophila) 		PF00176
(SNF2_N)
PF00271
(Helicase_C) 		5 LEU A 225
LEU A 239
ILE A 290
ILE A 312
PHE A 333
 None
 1.14A 4a7aB-5jxrA:
undetectable		 4a7aB-5jxrA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lnk MITOCHONDRIAL
COMPLEX I, ND5
SUBUNIT

(Ovis aries) 		PF00361
(Proton_antipo_M)
PF00662
(Proton_antipo_N)
PF06455
(NADH5_C) 		5 LEU L 431
LEU L 373
ILE L 356
ILE L 346
PHE L 340
 None
 1.14A 4a7aB-5lnkL:
undetectable		 4a7aB-5lnkL:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lsl COLD SENSITIVE U2
SNRNA SUPPRESSOR 1
PROTEIN HSH49

(Saccharomyces
cerevisiae) 		PF00076
(RRM_1)
PF04046
(PSP) 		5 LEU A  25
LEU A  28
ILE A  30
ILE A  55
TYR E 345
 None
 1.10A 4a7aB-5lslA:
undetectable		 4a7aB-5lslA:
12.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m0t ALPHA-KETOGLUTARATE-
DEPENDENT NON-HEME
IRON OXYGENASE EASH

(Aspergillus
japonicus) 		PF05721
(PhyH) 		5 LEU A  95
LEU A  99
CYH A 100
ILE A  35
PHE A  24
 None
 0.85A 4a7aB-5m0tA:
undetectable		 4a7aB-5m0tA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mrw POTASSIUM-TRANSPORTI
NG ATPASE
ATP-BINDING SUBUNIT

(Escherichia
coli) 		PF00122
(E1-E2_ATPase)
PF00702
(Hydrolase) 		5 PRO B 264
LEU B 225
LEU B 221
ILE B 580
ILE B 267
 None
 1.06A 4a7aB-5mrwB:
undetectable		 4a7aB-5mrwB:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n5z RNA POLYMERASE
I-SPECIFIC
TRANSCRIPTION
INITIATION FACTOR
RRN3

(Saccharomyces
cerevisiae) 		PF05327
(RRN3) 		5 LEU O 100
LEU O  97
LEU O  93
ILE O  74
ILE O 119
 None
 0.98A 4a7aB-5n5zO:
undetectable		 4a7aB-5n5zO:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vm9 PROTEIN ARGONAUTE-3

(Homo sapiens) 		no annotation 5 LEU A 780
LEU A 783
LEU A 787
CYH A 788
ILE A 666
 None
 0.80A 4a7aB-5vm9A:
undetectable		 4a7aB-5vm9A:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wea PROTEIN ARGONAUTE-2

(Homo sapiens) 		no annotation 5 LEU A 779
LEU A 782
LEU A 786
CYH A 787
ILE A 665
 None
 0.73A 4a7aB-5weaA:
undetectable		 4a7aB-5weaA:
9.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wp0 NH(3)-DEPENDENT
NAD(+) SYNTHETASE

(Aliivibrio
fischeri) 		PF02540
(NAD_synthase) 		5 PRO A 189
LEU A 164
LEU A  40
CYH A  37
ILE A  28
 None
 1.10A 4a7aB-5wp0A:
undetectable		 4a7aB-5wp0A:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xd6 PROTEIN KINASE
SUPERFAMILY PROTEIN

(Arabidopsis
thaliana) 		no annotation 5 LEU A 184
LEU A 187
ILE A 196
GLN A 223
ILE A 200
 None
 1.07A 4a7aB-5xd6A:
undetectable		 4a7aB-5xd6A:
9.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ybp PRHA

(Penicillium
brasilianum) 		no annotation 5 LEU A  92
LEU A  96
CYH A  97
ILE A  33
PHE A  22
 None
 0.89A 4a7aB-5ybpA:
undetectable		 4a7aB-5ybpA:
9.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6a8m -

(-) 		no annotation 5 LEU A  57
LEU A  56
ILE A 102
ILE A  66
PHE A  23
 None
 1.08A 4a7aB-6a8mA:
undetectable		 4a7aB-6a8mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dbr -

(-) 		no annotation 5 PRO B 134
LEU B 155
LEU B 142
LEU B  91
ILE B 185
 None
 1.07A 4a7aB-6dbrB:
undetectable		 4a7aB-6dbrB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6de8 BIFUNCTIONAL PROTEIN
FOLD

(Campylobacter
jejuni) 		no annotation 5 LEU A  76
LEU A  79
LEU A  83
ILE A 111
ILE A  36
 None
 1.07A 4a7aB-6de8A:
undetectable		 4a7aB-6de8A:
9.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fhf -

(-) 		no annotation 5 LEU A 302
LEU A 305
LEU A 309
ILE A 265
ILE A 249
 None
 1.14A 4a7aB-6fhfA:
undetectable		 4a7aB-6fhfA:
undetectable