SIMILAR PATTERNS OF AMINO ACIDS FOR 4A6N_D_T1CD392

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3p9u TETX2 PROTEIN

(Bacteroides
thetaiotaomicron) 		PF01494
(FAD_binding_3) 		8 GLN A 192
ARG A 213
ASN A 226
HIS A 234
GLY A 236
SER A 238
PRO A 318
MET A 375
 FAD  A 401 (-3.4A)
SO4  A   1 (-4.5A)
SO4  A   1 (-4.5A)
SO4  A   1 ( 4.6A)
None
None
FAD  A 401 (-4.4A)
None
 0.58A 4a6nD-3p9uA:
58.3		 4a6nD-3p9uA:
94.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT

(Homo sapiens) 		PF00454
(PI3_PI4_kinase)
PF02259
(FAT)
PF02260
(FATC)
PF08163
(NUC194) 		5 GLN C3564
ARG C3696
ASN C3697
GLY C3565
MET C3796
 None
 1.44A 4a6nD-5y3rC:
undetectable		 4a6nD-5y3rC:
7.14