SIMILAR PATTERNS OF AMINO ACIDS FOR 4A6N_A_T1CA392

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dbj IGG1-KAPPA DB3 FAB
(HEAVY CHAIN)


(Mus musculus)
PF07654
(C1-set)
PF07686
(V-set)
5 GLN H   6
PHE H  91
ASN H  35
GLY H 104
ALA H  40
None
None
AE2  H 229 (-2.9A)
None
None
1.20A 4a6nA-1dbjH:
undetectable
4a6nA-1dbjH:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f76 DIHYDROOROTATE
DEHYDROGENASE
(QUINONE)


(Escherichia
coli)
PF01180
(DHO_dh)
5 GLY A  94
ALA A  62
GLY A  63
GLU A  83
ASN A 139
None
FMN  A1337 (-3.7A)
FMN  A1337 (-3.1A)
None
FMN  A1337 (-3.3A)
1.27A 4a6nA-1f76A:
undetectable
4a6nA-1f76A:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h0h FORMATE
DEHYDROGENASE
SUBUNIT ALPHA


(Desulfovibrio
gigas)
PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4)
5 ASN A 198
GLY A 408
GLY A 864
GLU A 548
ASN A 518
MGD  A1002 (-3.4A)
MGD  A1002 (-3.2A)
None
None
None
1.27A 4a6nA-1h0hA:
undetectable
4a6nA-1h0hA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i2m REGULATOR OF
CHROMOSOME
CONDENSATION 1


(Homo sapiens)
PF00415
(RCC1)
5 PHE B  91
ASN B  94
GLY B 113
ALA B  74
GLY B  75
None
1.26A 4a6nA-1i2mB:
undetectable
4a6nA-1i2mB:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o50 CBS
DOMAIN-CONTAINING
PREDICTED PROTEIN
TM0935


(Thermotoga
maritima)
PF00571
(CBS)
5 ASN A  45
GLY A 124
PRO A 118
GLU A 134
MET A  98
None
1.27A 4a6nA-1o50A:
undetectable
4a6nA-1o50A:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pvd PYRUVATE
DECARBOXYLASE


(Saccharomyces
cerevisiae)
PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N)
5 ARG A 224
GLY A 250
ALA A 287
GLY A 286
GLU A 308
None
1.24A 4a6nA-1pvdA:
0.9
4a6nA-1pvdA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1si8 CATALASE

(Enterococcus
faecalis)
PF00199
(Catalase)
PF06628
(Catalase-rel)
5 PHE A 111
GLY A 126
ALA A  60
GLY A  59
MET A 295
None
HEM  A 501 (-3.8A)
None
None
None
1.20A 4a6nA-1si8A:
undetectable
4a6nA-1si8A:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ulv GLUCODEXTRANASE

(Arthrobacter
globiformis)
PF00723
(Glyco_hydro_15)
PF09136
(Glucodextran_B)
PF09137
(Glucodextran_N)
PF09985
(Glucodextran_C)
5 GLN A 629
GLY A 574
PRO A 312
ALA A 317
GLY A 314
None
1.27A 4a6nA-1ulvA:
undetectable
4a6nA-1ulvA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uuo DIHYDROOROTATE
DEHYDROGENASE


(Rattus rattus)
PF01180
(DHO_dh)
5 GLY A 128
ALA A  96
GLY A  97
GLU A 117
ASN A 181
None
FMN  A1398 (-3.7A)
FMN  A1398 (-3.0A)
None
FMN  A1398 (-3.2A)
1.24A 4a6nA-1uuoA:
undetectable
4a6nA-1uuoA:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wyt GLYCINE
DEHYDROGENASE
(DECARBOXYLATING)
SUBUNIT 1
GLYCINE
DEHYDROGENASE
SUBUNIT 2
(P-PROTEIN)


(Thermus
thermophilus)
PF02347
(GDC-P)
5 ARG A 285
GLY A 270
ALA B 133
GLY B 132
GLU B 136
None
1.08A 4a6nA-1wytA:
undetectable
4a6nA-1wytA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e9q 11S GLOBULIN SUBUNIT
BETA


(Cucurbita
maxima)
PF00190
(Cupin_1)
5 GLN A  91
GLY A  92
ALA A  45
GLY A  46
GLU A  44
None
1.20A 4a6nA-2e9qA:
undetectable
4a6nA-2e9qA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fhx SPM-1

(Pseudomonas
aeruginosa)
PF00753
(Lactamase_B)
5 PHE B  61
PRO B  86
GLY B 123
GLU B 126
ASN B  89
None
1.31A 4a6nA-2fhxB:
undetectable
4a6nA-2fhxB:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h1n OLIGOENDOPEPTIDASE F

(Geobacillus
stearothermophilus)
PF01432
(Peptidase_M3)
5 GLY A 472
ALA A 433
GLU A 436
ASN A 437
MET A 440
None
1.28A 4a6nA-2h1nA:
undetectable
4a6nA-2h1nA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j2m CATALASE

(Exiguobacterium
oxidotolerans)
PF00199
(Catalase)
PF06628
(Catalase-rel)
5 PHE A 113
GLY A 128
ALA A  62
GLY A  61
MET A 297
None
HEM  A 501 (-3.7A)
None
None
None
1.12A 4a6nA-2j2mA:
undetectable
4a6nA-2j2mA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ldk UNCHARACTERIZED
PROTEIN


(Paenarthrobacter
aurescens)
PF08327
(AHSA1)
5 GLN A 134
PHE A  94
GLY A 106
GLY A 142
GLU A 149
None
1.22A 4a6nA-2ldkA:
undetectable
4a6nA-2ldkA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nrx UVRABC SYSTEM
PROTEIN C


(Thermotoga
maritima)
PF08459
(UvrC_HhH_N)
5 PHE A 427
GLY A 365
ALA A 455
GLY A 431
GLU A 458
None
None
None
SO4  A 903 (-3.5A)
None
0.91A 4a6nA-2nrxA:
undetectable
4a6nA-2nrxA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2tpt THYMIDINE
PHOSPHORYLASE


(Escherichia
coli)
PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N)
PF07831
(PYNP_C)
5 GLY A 206
ALA A 247
GLY A  91
GLU A 258
ASN A 269
None
1.28A 4a6nA-2tptA:
2.8
4a6nA-2tptA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uvd 3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
REDUCTASE


(Bacillus
anthracis)
PF13561
(adh_short_C2)
5 GLN A  82
PHE A  80
GLY A  81
ALA A  25
GLY A  28
None
1.22A 4a6nA-2uvdA:
6.6
4a6nA-2uvdA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vdc GLUTAMATE SYNTHASE
[NADPH] SMALL CHAIN


(Azospirillum
brasilense)
PF07992
(Pyr_redox_2)
PF14691
(Fer4_20)
5 PRO G 157
ALA G 161
GLY G 159
GLU G 165
ASN G  89
FAD  G 484 (-3.6A)
None
None
None
None
1.22A 4a6nA-2vdcG:
5.4
4a6nA-2vdcG:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wk2 CHITINASE A

(Serratia
marcescens)
PF00704
(Glyco_hydro_18)
PF08329
(ChitinaseA_N)
5 PHE A 316
ASN A 323
GLY A 319
GLY A 273
MET A 388
None
None
None
None
NGT  A1565 (-3.7A)
1.20A 4a6nA-2wk2A:
undetectable
4a6nA-2wk2A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wsb GALACTITOL
DEHYDROGENASE


(Rhodobacter
sphaeroides)
PF13561
(adh_short_C2)
5 ARG A  29
GLY A  56
ALA A  47
GLY A  20
GLU A  44
None
None
NAD  A 500 ( 4.9A)
NAD  A 500 ( 3.8A)
NAD  A 500 ( 4.1A)
1.23A 4a6nA-2wsbA:
4.7
4a6nA-2wsbA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xf2 CATALASE

(Penicillium
janthinellum)
PF00199
(Catalase)
PF06628
(Catalase-rel)
5 PHE A 121
GLY A 136
ALA A  70
GLY A  69
MET A 309
None
HDD  A 690 (-3.9A)
None
None
None
1.19A 4a6nA-2xf2A:
3.7
4a6nA-2xf2A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ada SARCOSINE OXIDASE
BETA SUBUNIT


(Corynebacterium
sp. U-96)
PF01266
(DAO)
5 GLN B 294
GLY B 326
ALA B 224
GLY B  27
ASN B 349
None
FAD  B   1 (-3.5A)
None
FAD  B   1 (-3.3A)
None
1.32A 4a6nA-3adaB:
14.8
4a6nA-3adaB:
24.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3asi NEUREXIN-1-ALPHA

(Bos taurus)
PF02210
(Laminin_G_2)
5 GLN A1064
PHE A1068
GLY A1067
GLY A1059
ASN A1083
None
1.22A 4a6nA-3asiA:
undetectable
4a6nA-3asiA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3egw RESPIRATORY NITRATE
REDUCTASE 1 ALPHA
CHAIN
RESPIRATORY NITRATE
REDUCTASE 1 BETA
CHAIN


(Escherichia
coli)
PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF13247
(Fer4_11)
PF14710
(Nitr_red_alph_N)
PF14711
(Nitr_red_bet_C)
5 GLN A1152
PHE B 176
GLY B  49
GLU B  57
ASN B 160
None
1.28A 4a6nA-3egwA:
2.5
4a6nA-3egwA:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fk5 3-OXOACYL-SYNTHASE
III


(Xanthomonas
oryzae)
PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III)
5 PHE A 126
ASN A 121
GLY A 129
ALA A 187
GLY A 150
None
1.27A 4a6nA-3fk5A:
undetectable
4a6nA-3fk5A:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3grh ACYL-COA THIOESTER
HYDROLASE YBGC


(Escherichia
coli)
PF01095
(Pectinesterase)
5 ARG A  14
PHE A 340
GLY A 311
ALA A 335
GLY A 388
None
1.08A 4a6nA-3grhA:
undetectable
4a6nA-3grhA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ihv SUSD HOMOLOG

(Bacteroides
thetaiotaomicron)
PF07980
(SusD_RagB)
PF14322
(SusD-like_3)
5 GLY A 489
PRO A 390
ALA A 322
GLY A 307
ASN A 323
CL  A   1 (-3.7A)
None
None
None
None
1.24A 4a6nA-3ihvA:
undetectable
4a6nA-3ihvA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j31 A223 PENTON BASE

(Sulfolobus
turreted
icosahedral
virus 1)
no annotation 5 GLY Q  53
PRO Q 157
ALA Q 201
GLY Q 202
ASN Q 159
None
1.30A 4a6nA-3j31Q:
undetectable
4a6nA-3j31Q:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j9u V-TYPE PROTON ATPASE
CATALYTIC SUBUNIT A


(Saccharomyces
cerevisiae)
no annotation 5 PRO C  84
ALA C  26
GLY C  82
GLU C  38
ASN C  39
None
1.25A 4a6nA-3j9uC:
undetectable
4a6nA-3j9uC:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3koy D-ORNITHINE
AMINOMUTASE E
COMPONENT


(Acetoanaerobium
sticklandii)
PF02310
(B12-binding)
PF09043
(Lys-AminoMut_A)
PF16554
(OAM_dimer)
5 GLY A 166
ALA A 216
GLY A 180
ASN A 261
MET A 257
None
1.34A 4a6nA-3koyA:
undetectable
4a6nA-3koyA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lpp SUCRASE-ISOMALTASE

(Homo sapiens)
PF00088
(Trefoil)
PF01055
(Glyco_hydro_31)
PF16863
(NtCtMGAM_N)
5 GLN A 245
GLY A 243
ALA A 599
GLY A 598
ASN A 572
None
1.13A 4a6nA-3lppA:
undetectable
4a6nA-3lppA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m1h LYSINE SPECIFIC
CYSTEINE PROTEASE


(Porphyromonas
gingivalis)
PF07675
(Cleaved_Adhesin)
5 PHE A1584
ASN A1490
GLY A1585
ALA A1536
ASN A1537
None
CA  A2001 (-2.9A)
None
None
None
1.34A 4a6nA-3m1hA:
undetectable
4a6nA-3m1hA:
18.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3p9u TETX2 PROTEIN

(Bacteroides
thetaiotaomicron)
PF01494
(FAD_binding_3)
7 GLN A 192
ARG A 213
ASN A 226
ALA A 320
GLY A 321
ASN A 371
MET A 375
FAD  A 401 (-3.4A)
SO4  A   1 (-4.5A)
SO4  A   1 (-4.5A)
None
None
None
None
0.82A 4a6nA-3p9uA:
58.3
4a6nA-3p9uA:
94.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3p9u TETX2 PROTEIN

(Bacteroides
thetaiotaomicron)
PF01494
(FAD_binding_3)
8 GLN A 192
ARG A 213
ASN A 226
GLY A 236
PRO A 318
ALA A 320
GLY A 321
MET A 375
FAD  A 401 (-3.4A)
SO4  A   1 (-4.5A)
SO4  A   1 (-4.5A)
None
FAD  A 401 (-4.4A)
None
None
None
0.60A 4a6nA-3p9uA:
58.3
4a6nA-3p9uA:
94.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pea ENOYL-COA
HYDRATASE/ISOMERASE
FAMILY PROTEIN


(Bacillus
anthracis)
PF00378
(ECH_1)
5 PHE A 235
GLY A 232
ALA A 245
GLY A 243
GLU A 249
None
1.29A 4a6nA-3peaA:
undetectable
4a6nA-3peaA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3poy NEUREXIN-1-ALPHA

(Bos taurus)
PF00008
(EGF)
PF02210
(Laminin_G_2)
5 GLN A1124
PHE A1128
GLY A1127
GLY A1119
ASN A1143
None
1.20A 4a6nA-3poyA:
undetectable
4a6nA-3poyA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pvo C-REACTIVE PROTEIN

(Homo sapiens)
PF00354
(Pentaxin)
5 GLN A 139
PHE A 142
GLY A 143
ALA A 129
GLY A 128
None
0.96A 4a6nA-3pvoA:
undetectable
4a6nA-3pvoA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q3q ALKALINE PHOSPHATASE

(Sphingomonas
sp. BSAR-1)
PF01663
(Phosphodiest)
5 PHE A 260
GLY A 259
PRO A 192
GLY A 190
ASN A 211
None
1.19A 4a6nA-3q3qA:
undetectable
4a6nA-3q3qA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qdf 2-HYDROXYHEPTA-2,4-D
IENE-1,7-DIOATE
ISOMERASE


(Mycobacterium
marinum)
PF01557
(FAA_hydrolase)
PF10370
(DUF2437)
5 PHE A 116
ASN A 257
GLY A 118
ALA A 195
GLY A 194
None
1.01A 4a6nA-3qdfA:
undetectable
4a6nA-3qdfA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t4j HISTIDINE KINASE 4

(Arabidopsis
thaliana)
PF03924
(CHASE)
5 PHE A 153
ASN A 158
GLY A 379
ALA A 322
GLY A 321
None
None
None
ZIP  A 400 (-3.5A)
None
1.15A 4a6nA-3t4jA:
undetectable
4a6nA-3t4jA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uiw GLUTAREDOXIN 2

(Danio rerio)
PF00462
(Glutaredoxin)
5 GLN A  89
PHE A  85
GLY A  88
ALA A  73
GLY A  77
None
1.34A 4a6nA-3uiwA:
undetectable
4a6nA-3uiwA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w5f BETA-GALACTOSIDASE

(Solanum
lycopersicum)
PF01301
(Glyco_hydro_35)
5 GLY A 303
PRO A 519
ALA A 496
GLY A 497
ASN A 556
None
None
EPE  A 805 ( 4.4A)
None
EPE  A 805 (-3.4A)
1.21A 4a6nA-3w5fA:
undetectable
4a6nA-3w5fA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wvo CRISPR-ASSOCIATED
PROTEIN, CSE1 FAMILY


(Thermobifida
fusca)
PF09481
(CRISPR_Cse1)
5 GLN A 316
ARG A 357
ASN A 224
ALA A 335
GLY A 339
None
1.27A 4a6nA-3wvoA:
undetectable
4a6nA-3wvoA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aef NEOPULLULANASE
(ALPHA-AMYLASE II)


(Pyrococcus
furiosus)
PF00128
(Alpha-amylase)
PF02903
(Alpha-amylase_N)
PF16561
(AMPK1_CBM)
5 PHE A 122
ASN A 587
GLY A 123
ALA A 490
GLY A 488
None
1.25A 4a6nA-4aefA:
undetectable
4a6nA-4aefA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ayz HEME-BINDING PROTEIN
2


(Homo sapiens)
PF04832
(SOUL)
5 ASN A  70
GLY A  65
ALA A 177
GLY A 178
GLU A 191
None
1.14A 4a6nA-4ayzA:
undetectable
4a6nA-4ayzA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c7v TRANSKETOLASE

(Lactobacillus
salivarius)
PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C)
5 ASN A 256
GLY A 264
PRO A  32
ALA A  35
GLY A  34
None
1.31A 4a6nA-4c7vA:
undetectable
4a6nA-4c7vA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cab CATALASE

(Deinococcus
radiodurans)
PF00199
(Catalase)
PF06628
(Catalase-rel)
5 PHE A 143
GLY A 158
ALA A  87
GLY A  86
MET A 327
None
HEM  A 537 (-4.0A)
None
None
None
1.25A 4a6nA-4cabA:
undetectable
4a6nA-4cabA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ccl 50S RIBOSOMAL
PROTEIN L16 ARGININE
HYDROXYLASE


(Escherichia
coli)
PF08007
(Cupin_4)
5 PHE A  28
ASN A  30
GLY A 176
PRO A  34
ALA A  95
None
1.33A 4a6nA-4cclA:
undetectable
4a6nA-4cclA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cx9 CYTOCHROME C, CLASS
II


(Shewanella
frigidimarina)
PF01322
(Cytochrom_C_2)
5 PHE A  23
ASN A  47
GLY A  24
ALA A 110
ASN A 113
HEC  A1129 ( 4.0A)
None
None
None
None
1.22A 4a6nA-4cx9A:
undetectable
4a6nA-4cx9A:
15.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eg2 CYTIDINE DEAMINASE

(Vibrio cholerae)
PF00383
(dCMP_cyt_deam_1)
PF08211
(dCMP_cyt_deam_2)
5 ARG A   4
GLY A 252
ALA A 103
GLY A  74
GLU A 104
None
None
URI  A 302 (-3.8A)
None
URI  A 302 (-3.0A)
1.17A 4a6nA-4eg2A:
undetectable
4a6nA-4eg2A:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4flx DNA POLYMERASE 1

(Pyrococcus
abyssi)
PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1)
5 GLN A 665
PHE A 152
GLY A 696
ALA A 215
GLY A 211
GLN  A 665 ( 0.6A)
PHE  A 152 ( 1.3A)
GLY  A 696 ( 0.0A)
ALA  A 215 ( 0.0A)
GLY  A 211 ( 0.0A)
1.24A 4a6nA-4flxA:
undetectable
4a6nA-4flxA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fvv NEUROTOXIN

(Clostridium
botulinum)
PF07951
(Toxin_R_bind_C)
PF07953
(Toxin_R_bind_N)
5 ARG A1132
ASN A1135
GLY A 999
ALA A1282
GLU A1107
None
1.27A 4a6nA-4fvvA:
undetectable
4a6nA-4fvvA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i62 AMINO ACID ABC
TRANSPORTER,
PERIPLASMIC AMINO
ACID-BINDING
PROTEIN, PUTATIVE


(Streptococcus
pneumoniae)
PF00497
(SBP_bac_3)
5 PHE A  48
GLY A 107
PRO A 199
ALA A 201
GLY A 203
ARG  A 301 (-3.4A)
ARG  A 301 (-4.7A)
None
None
None
1.25A 4a6nA-4i62A:
undetectable
4a6nA-4i62A:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jc8 HOPS COMPONENT VPS33

(Chaetomium
thermophilum)
PF00995
(Sec1)
5 PHE A 157
ASN A 154
PRO A 245
GLY A 643
MET A 465
None
1.20A 4a6nA-4jc8A:
undetectable
4a6nA-4jc8A:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jcl CYCLOMALTODEXTRIN
GLUCANOTRANSFERASE


(Paenibacillus
macerans)
PF00128
(Alpha-amylase)
PF00686
(CBM_20)
PF01833
(TIG)
5 GLY A  99
PRO A 143
ALA A 198
GLY A 155
ASN A 193
None
EDO  A 720 ( 4.9A)
None
None
None
1.30A 4a6nA-4jclA:
undetectable
4a6nA-4jclA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k1c VACUOLAR CALCIUM ION
TRANSPORTER


(Saccharomyces
cerevisiae)
PF01699
(Na_Ca_ex)
5 GLN A 152
GLY A 145
ALA A 322
GLY A 320
ASN A 133
None
1.11A 4a6nA-4k1cA:
undetectable
4a6nA-4k1cA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k2n ENOYL-COA
HYDRATASE/CARNITHINE
RACEMASE


(Magnetospirillum
magneticum)
PF00378
(ECH_1)
5 ASN A  25
GLY A 112
ALA A  36
GLY A  34
GLU A  40
None
1.35A 4a6nA-4k2nA:
undetectable
4a6nA-4k2nA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k2n ENOYL-COA
HYDRATASE/CARNITHINE
RACEMASE


(Magnetospirillum
magneticum)
PF00378
(ECH_1)
5 ASN A  25
GLY A 113
ALA A  36
GLY A  34
GLU A  40
None
1.33A 4a6nA-4k2nA:
undetectable
4a6nA-4k2nA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lk5 ENOYL-COA HYDRATASE

(Mycobacterium
avium)
PF00378
(ECH_1)
5 ASN A  35
GLY A  73
ALA A  46
GLY A  44
GLU A  50
None
1.31A 4a6nA-4lk5A:
undetectable
4a6nA-4lk5A:
25.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o9x TCDB2, TCCC3

(Photorhabdus
luminescens)
PF03534
(SpvB)
PF12255
(TcdB_toxin_midC)
PF12256
(TcdB_toxin_midN)
5 GLY A 705
ALA A  97
GLY A  98
ASN A  94
MET A  70
None
0.96A 4a6nA-4o9xA:
undetectable
4a6nA-4o9xA:
11.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qor CATALASE

(Bacillus
pumilus)
PF00199
(Catalase)
PF06628
(Catalase-rel)
5 PHE A 114
GLY A 129
ALA A  63
GLY A  62
MET A 298
None
HEM  A 501 ( 3.8A)
None
None
None
1.31A 4a6nA-4qorA:
undetectable
4a6nA-4qorA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4um8 INTEGRIN ALPHA-V
INTEGRIN BETA-6


(Homo sapiens)
PF00362
(Integrin_beta)
PF01839
(FG-GAP)
PF08441
(Integrin_alpha2)
PF17205
(PSI_integrin)
5 PHE B 259
GLY B 260
PRO A 244
ALA A 246
GLY A 251
None
1.30A 4a6nA-4um8B:
undetectable
4a6nA-4um8B:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ye5 PEPTIDOGLYCAN
SYNTHETASE
PENICILLIN-BINDING
PROTEIN 3


(Bifidobacterium
adolescentis)
PF00905
(Transpeptidase)
PF03717
(PBP_dimer)
5 GLN A 226
ASN A 169
GLY A 172
ALA A 122
GLY A 121
None
1.06A 4a6nA-4ye5A:
undetectable
4a6nA-4ye5A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yyc PUTATIVE
TRIMETHYLAMINE
METHYLTRANSFERASE


(Sinorhizobium
meliloti)
PF06253
(MTTB)
5 GLN A 267
PHE A 228
ASN A 235
GLU A 124
ASN A 122
None
1.34A 4a6nA-4yycA:
undetectable
4a6nA-4yycA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z37 PUTATIVE MIXED
POLYKETIDE
SYNTHASE/NON-RIBOSOM
AL PEPTIDE
SYNTHETASE


(Brevibacillus
brevis)
PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc)
5 GLN A2877
GLY A2872
ALA A2860
GLY A2899
GLU A2825
None
1.34A 4a6nA-4z37A:
undetectable
4a6nA-4z37A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b3j NMDA GLUTAMATE
RECEPTOR SUBUNIT


(Xenopus laevis)
PF01094
(ANF_receptor)
5 PHE A 137
GLY A 365
PRO A 117
ALA A 111
GLY A 112
None
1.35A 4a6nA-5b3jA:
3.6
4a6nA-5b3jA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cer BD0816

(Bdellovibrio
bacteriovorus)
PF02113
(Peptidase_S13)
5 PHE A 334
ASN A 333
GLY A 336
ALA A 386
GLY A 384
None
1.28A 4a6nA-5cerA:
undetectable
4a6nA-5cerA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5csu 4-ALPHA-GLUCANOTRANS
FERASE DPE1,
CHLOROPLASTIC/AMYLOP
LASTIC


(Arabidopsis
thaliana)
PF02446
(Glyco_hydro_77)
5 ARG A 359
GLY A 292
PRO A 135
ALA A 137
GLY A 138
None
None
None
GLC  A 605 ( 4.1A)
None
1.09A 4a6nA-5csuA:
1.0
4a6nA-5csuA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dgq PUTATIVE
ENDOGLUCANASE-RELATE
D PROTEIN


(Photobacterium
profundum)
PF00759
(Glyco_hydro_9)
5 GLN A 346
PHE A 405
ASN A 404
ALA A 372
GLY A 373
None
1.20A 4a6nA-5dgqA:
undetectable
4a6nA-5dgqA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f7s GLYCOSIDE HYDROLASE
FAMILY 31


(Trueperella
pyogenes)
PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2)
5 GLY A 279
ALA A 550
GLY A 551
GLU A 180
MET A 213
None
1.16A 4a6nA-5f7sA:
undetectable
4a6nA-5f7sA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5frt DIMERIC (2FE-2S)
PROTEIN


(Azotobacter
vinelandii)
PF00111
(Fer2)
5 PHE A 115
GLY A 117
GLY A  29
GLU A  33
ASN A  34
None
1.33A 4a6nA-5frtA:
undetectable
4a6nA-5frtA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ft6 CYSTEINE DESULFURASE
CSDA


(Escherichia
coli)
PF00266
(Aminotran_5)
5 GLN A 168
PHE A 218
GLY A 197
ALA A  73
GLU A  70
None
1.18A 4a6nA-5ft6A:
undetectable
4a6nA-5ft6A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gpr CHITINASE

(Ostrinia
furnacalis)
PF00704
(Glyco_hydro_18)
PF08329
(ChitinaseA_N)
5 PHE A 309
ASN A 316
GLY A 312
GLY A 266
MET A 381
PHE  A 309 ( 1.3A)
ASN  A 316 ( 0.6A)
GLY  A 312 ( 0.0A)
GLY  A 266 ( 0.0A)
MET  A 381 ( 0.0A)
1.13A 4a6nA-5gprA:
undetectable
4a6nA-5gprA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gqq HEME-BINDING PROTEIN
2


(Homo sapiens)
PF04832
(SOUL)
5 ASN A  70
GLY A  65
ALA A 177
GLY A 178
GLU A 191
None
1.17A 4a6nA-5gqqA:
undetectable
4a6nA-5gqqA:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h7j ELONGATION FACTOR 2

(Pyrococcus
horikoshii)
no annotation 5 GLY A 438
PRO A 628
ALA A 698
GLY A 699
GLU A 670
None
1.20A 4a6nA-5h7jA:
undetectable
4a6nA-5h7jA:
11.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ito NOPALINE-BINDING
PERIPLASMIC PROTEIN


(Agrobacterium
fabrum)
PF00497
(SBP_bac_3)
5 PHE A 162
GLY A 163
GLY A 227
GLU A 149
MET A 178
None
1.24A 4a6nA-5itoA:
undetectable
4a6nA-5itoA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iuw ALDEHYDE
DEHYDROGENASE FAMILY
PROTEIN


(Pseudomonas
syringae group
genomosp. 3)
no annotation 5 GLN A 349
ASN A 297
GLY A 404
ALA A 268
GLY A 244
None
None
None
None
NAD  A 700 (-2.9A)
1.26A 4a6nA-5iuwA:
undetectable
4a6nA-5iuwA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5je8 3-HYDROXYISOBUTYRATE
DEHYDROGENASE


(Bacillus cereus)
PF03446
(NAD_binding_2)
PF14833
(NAD_binding_11)
5 PHE A 135
ASN A 157
GLY A 152
ALA A 118
GLY A 138
None
1.35A 4a6nA-5je8A:
4.2
4a6nA-5je8A:
24.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k1z AMINODEOXYFUTALOSINE
NUCLEOSIDASE


(Helicobacter
pylori)
PF01048
(PNP_UDP_1)
5 PHE A 208
ASN A 199
GLY A 205
ALA A 216
MET A  10
4CT  A 301 (-3.5A)
None
None
None
4CT  A 301 ( 2.9A)
1.34A 4a6nA-5k1zA:
undetectable
4a6nA-5k1zA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kf7 BIFUNCTIONAL PROTEIN
PUTA


(Sinorhizobium
meliloti)
PF00171
(Aldedh)
PF01619
(Pro_dh)
PF14850
(Pro_dh-DNA_bdg)
5 GLN A1191
ASN A1201
PRO A 804
ALA A1170
GLY A 802
None
1.31A 4a6nA-5kf7A:
undetectable
4a6nA-5kf7A:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lw7 ABC TRANSPORTER
ATP-BINDING PROTEIN


(Pyrococcus
abyssi)
PF00005
(ABC_tran)
PF00037
(Fer4)
PF04068
(RLI)
5 GLN B 410
ARG B 210
GLY B 217
GLY B 536
GLU B 534
None
0.92A 4a6nA-5lw7B:
undetectable
4a6nA-5lw7B:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mqs BETA-L-ARABINOBIOSID
ASE


(Bacteroides
thetaiotaomicron)
PF13088
(BNR_2)
5 ASN A 169
GLY A 155
ALA A  94
ASN A  76
MET A 399
None
1.30A 4a6nA-5mqsA:
undetectable
4a6nA-5mqsA:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mvd DIHYDROOROTATE
DEHYDROGENASE
(QUINONE),
MITOCHONDRIAL


(Homo sapiens)
PF01180
(DHO_dh)
5 GLY A 128
ALA A  96
GLY A  97
GLU A 117
ASN A 181
None
FMN  A 401 (-3.4A)
FMN  A 401 (-3.3A)
None
FMN  A 401 (-3.1A)
1.25A 4a6nA-5mvdA:
undetectable
4a6nA-5mvdA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mzs FERRIC ENTEROBACTIN
RECEPTOR


(Pseudomonas
aeruginosa)
no annotation 5 ARG A 104
GLY A 694
ALA A 480
GLY A 481
GLU A 386
None
1.31A 4a6nA-5mzsA:
undetectable
4a6nA-5mzsA:
11.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ng6 CRISPR-ASSOCIATED
ENDONUCLEASE CPF1


(Francisella
tularensis)
no annotation 5 ASN A1093
GLY A1090
ALA A1079
GLY A1080
GLU A1006
None
1.03A 4a6nA-5ng6A:
undetectable
4a6nA-5ng6A:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nvm EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4E
TYPE 2


(Homo sapiens)
PF01652
(IF4E)
5 GLN A  84
ASN A  59
GLY A  86
ALA A 169
GLY A 168
None
1.03A 4a6nA-5nvmA:
2.2
4a6nA-5nvmA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u7s FRUCTOSE-1,6-BISPHOS
PHATE ALDOLASE


(Acinetobacter
baumannii)
PF01116
(F_bP_aldolase)
5 ARG A 205
PHE A 203
GLY A 257
ALA A 213
GLY A 209
None
1.26A 4a6nA-5u7sA:
undetectable
4a6nA-5u7sA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wpw 11S GLOBULIN ISOFORM
1


(Cocos nucifera)
no annotation 5 GLN A 109
GLY A 110
ALA A  63
GLY A  64
GLU A  62
None
1.15A 4a6nA-5wpwA:
undetectable
4a6nA-5wpwA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wxu 11S GLOBULIN

(Wrightia
tinctoria)
no annotation 5 GLN A 108
GLY A 109
ALA A  62
GLY A  63
GLU A  61
None
1.16A 4a6nA-5wxuA:
undetectable
4a6nA-5wxuA:
10.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xgv PYRE3

(Streptomyces
rugosporus)
no annotation 5 GLN A  56
ARG A 322
ASN A 297
GLY A 440
GLY A 289
None
1.33A 4a6nA-5xgvA:
26.8
4a6nA-5xgvA:
14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xm3 GLUCOSE
DEHYDROGENASE


(Methylophaga
aminisulfidivorans)
no annotation 5 ASN A 264
GLY A 233
ALA A 207
GLY A 210
ASN A 292
None
None
PQQ  A 701 (-3.0A)
None
MG  A 702 ( 3.0A)
1.30A 4a6nA-5xm3A:
undetectable
4a6nA-5xm3A:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xns CHROMOSOME PARTITION
PROTEIN SMC


(Pyrococcus
furiosus)
PF02463
(SMC_N)
5 GLN A1123
PHE A  86
ASN A  87
ALA A  83
GLU A  81
None
1.11A 4a6nA-5xnsA:
undetectable
4a6nA-5xnsA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT


(Homo sapiens)
PF00454
(PI3_PI4_kinase)
PF02259
(FAT)
PF02260
(FATC)
PF08163
(NUC194)
5 GLN C3564
ARG C3696
GLY C3565
ALA C3574
MET C3796
None
1.23A 4a6nA-5y3rC:
undetectable
4a6nA-5y3rC:
7.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ys9 ACYL-COENZYME A
OXIDASE 3


(Yarrowia
lipolytica)
no annotation 5 ASN A 261
GLY A 248
ALA A 196
GLU A 175
ASN A 193
FAD  A 801 (-3.7A)
None
None
None
None
1.18A 4a6nA-5ys9A:
undetectable
4a6nA-5ys9A:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zl9 CHITINASE AB

(Serratia
marcescens)
no annotation 5 PHE A 316
ASN A 323
GLY A 319
GLY A 273
MET A 390
None
None
None
None
GOL  A 706 (-3.3A)
1.12A 4a6nA-5zl9A:
undetectable
4a6nA-5zl9A:
12.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cfw MEMBRANE-BOUND
HYDROGENASE SUBUNIT
ALPHA
MEMBRANE-BOUND
HYDROGENASE SUBUNIT
BETA


(Pyrococcus
furiosus)
no annotation 5 ARG L  54
GLY L  47
PRO K 146
GLY K 153
GLU K 151
None
1.25A 4a6nA-6cfwL:
undetectable
4a6nA-6cfwL:
10.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f85 CYTOCHROME P450
CYP260A1


(Sorangium
cellulosum)
no annotation 5 PHE A  38
ASN A   7
GLY A  39
ALA A 383
GLY A 377
None
1.31A 4a6nA-6f85A:
undetectable
4a6nA-6f85A:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fay ODZ3 PROTEIN

(Mus musculus)
no annotation 5 ARG A1797
PHE A1779
ASN A1777
ALA A1740
ASN A1744
None
1.26A 4a6nA-6fayA:
undetectable
4a6nA-6fayA:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fd5 -

(-)
no annotation 5 PHE A  71
GLY A  68
ALA A  41
GLY A  44
GLU A   5
None
1.33A 4a6nA-6fd5A:
undetectable
4a6nA-6fd5A:
undetectable