SIMILAR PATTERNS OF AMINO ACIDS FOR 4A6E_A_SAMA1349_0
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ahi | 7ALPHA-HYDROXYSTEROIDDEHYDROGENASE (Escherichiacoli) |
PF13561(adh_short_C2) | 5 | GLY A 24GLY A 20ILE A 29VAL A 51ALA A 96 | NoneNAI A 302 ( 4.1A)NoneNoneNAI A 302 ( 4.3A) | 1.17A | 4a6eA-1ahiA:4.4 | 4a6eA-1ahiA:20.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1avb | ARCELIN-1 (Phaseolusvulgaris) |
PF00139(Lectin_legB) | 5 | PHE A 65GLY A 199ILE A 52VAL A 196ALA A 86 | None | 1.08A | 4a6eA-1avbA:undetectable | 4a6eA-1avbA:23.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1c0i | D-AMINO ACID OXIDASE (Rhodotorulatoruloides) |
PF01266(DAO) | 5 | PHE A1157LEU A1021GLY A1013GLY A1016VAL A1009 | NoneNoneFAD A1363 (-3.3A)NoneNone | 1.13A | 4a6eA-1c0iA:undetectable | 4a6eA-1c0iA:24.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ioa | ARCELIN-5A (Phaseolusvulgaris) |
PF00139(Lectin_legB) | 5 | PHE A 67GLY A 201ILE A 56VAL A 198ALA A 88 | None | 1.00A | 4a6eA-1ioaA:undetectable | 4a6eA-1ioaA:20.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1k1x | 4-ALPHA-GLUCANOTRANSFERASE (Thermococcuslitoralis) |
PF03065(Glyco_hydro_57)PF09094(DUF1925)PF09095(DUF1926) | 5 | GLY A 9ILE A 177VAL A 143PHE A 211ASP A 214 | None | 1.16A | 4a6eA-1k1xA:undetectable | 4a6eA-1k1xA:19.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1kc8 | RIBOSOMAL PROTEINL21E (Haloarculamarismortui) |
PF01157(Ribosomal_L21e) | 5 | PHE R 52GLY R 61ILE R 84VAL R 73ASP R 57 | None | 1.14A | 4a6eA-1kc8R:undetectable | 4a6eA-1kc8R:15.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1o5t | TRYPTOPHANYL-TRNASYNTHETASE (Homo sapiens) |
PF00579(tRNA-synt_1b) | 5 | PHE A 280GLY A 163GLY A 161ALA A 215ASP A 198 | None | 1.14A | 4a6eA-1o5tA:undetectable | 4a6eA-1o5tA:23.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1tkc | TRANSKETOLASE (Saccharomycescerevisiae) |
PF00456(Transketolase_N)PF02779(Transket_pyr)PF02780(Transketolase_C) | 5 | LEU A 224GLY A 220ILE A 244VAL A 217ALA A 38 | None | 1.02A | 4a6eA-1tkcA:2.9 | 4a6eA-1tkcA:19.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1tz6 | PUTATIVE SUGARKINASE (Salmonellaenterica) |
PF00294(PfkB) | 5 | LEU A 53GLY A 11GLY A 51VAL A 111ALA A 34 | None | 1.16A | 4a6eA-1tz6A:3.2 | 4a6eA-1tz6A:21.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1uan | HYPOTHETICAL PROTEINTT1542 (Thermusthermophilus) |
PF02585(PIG-L) | 5 | PHE A 213GLY A 19GLY A 14VAL A 6ARG A 194 | None | 1.03A | 4a6eA-1uanA:2.6 | 4a6eA-1uanA:21.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1uc8 | LYSINE BIOSYNTHESISENZYME (Thermusthermophilus) |
PF08443(RimK) | 5 | PHE A 256LEU A 53GLY A 269VAL A 184ALA A 20 | None | 1.14A | 4a6eA-1uc8A:undetectable | 4a6eA-1uc8A:24.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wy6 | HYPOTHETICAL PROTEINST1625 (Sulfurisphaeratokodaii) |
PF09205(DUF1955) | 5 | PHE A 46LEU A 20GLY A 27ILE A 66VAL A 62 | None | 0.93A | 4a6eA-1wy6A:undetectable | 4a6eA-1wy6A:18.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wzz | PROBABLEENDOGLUCANASE (Komagataeibacterxylinus) |
PF01270(Glyco_hydro_8) | 5 | PHE A 65GLY A 60GLY A 58VAL A 45ARG A 248 | None | 1.00A | 4a6eA-1wzzA:undetectable | 4a6eA-1wzzA:22.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ys9 | PROTEIN SPY1043 (Streptococcuspyogenes) |
PF13242(Hydrolase_like)PF13344(Hydrolase_6) | 5 | PHE A 142GLY A 119ILE A 143PHE A 178ALA A 163 | None | 1.14A | 4a6eA-1ys9A:undetectable | 4a6eA-1ys9A:20.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2c7z | 3-KETOACYL-COATHIOLASE 2 (Arabidopsisthaliana) |
PF00108(Thiolase_N)PF02803(Thiolase_C) | 5 | GLY A 297GLY A 299VAL A 82PHE A 70ASP A 261 | None | 1.01A | 4a6eA-2c7zA:undetectable | 4a6eA-2c7zA:22.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2d3a | GLUTAMINE SYNTHETASE (Zea mays) |
PF00120(Gln-synt_C)PF03951(Gln-synt_N) | 5 | GLY A 61GLY A 57ILE A 102VAL A 70ASP A 32 | None | 1.14A | 4a6eA-2d3aA:undetectable | 4a6eA-2d3aA:21.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2dr3 | UPF0273 PROTEINPH0284 (Pyrococcushorikoshii) |
PF06745(ATPase) | 5 | PHE A 39LEU A 16GLY A 11ILE A 231VAL A 233 | None | 0.97A | 4a6eA-2dr3A:undetectable | 4a6eA-2dr3A:19.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2g28 | PYRUVATEDEHYDROGENASE E1COMPONENT (Escherichiacoli) |
PF00456(Transketolase_N) | 6 | GLY A 363ILE A 386VAL A 292PHE A 227ALA A 114ARG A 82 | None | 1.07A | 4a6eA-2g28A:undetectable | 4a6eA-2g28A:18.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gh9 | MALTOSE/MALTODEXTRIN-BINDING PROTEIN (Thermusthermophilus) |
PF13416(SBP_bac_8) | 5 | LEU A 185GLY A 192GLY A 189ILE A 366ALA A 168 | None | 1.16A | 4a6eA-2gh9A:undetectable | 4a6eA-2gh9A:24.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ji9 | OXALYL-COADECARBOXYLASE (Oxalobacterformigenes) |
PF00205(TPP_enzyme_M)PF02775(TPP_enzyme_C)PF02776(TPP_enzyme_N) | 5 | LEU A 420GLY A 433GLY A 431ILE A 465PHE A 53 | None | 1.00A | 4a6eA-2ji9A:3.3 | 4a6eA-2ji9A:19.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2o0x | 3-PHOSPHOSHIKIMATE1-CARBOXYVINYLTRANSFERASE (Mycobacteriumtuberculosis) |
PF00275(EPSP_synthase) | 5 | PHE A 415LEU A 395GLY A 390ILE A 405ALA A 318 | None | 1.09A | 4a6eA-2o0xA:undetectable | 4a6eA-2o0xA:21.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2o3c | APEX NUCLEASE 1 (Danio rerio) |
PF03372(Exo_endo_phos) | 5 | LEU A 65GLY A 114GLY A 123ILE A 151ALA A 93 | None | 0.98A | 4a6eA-2o3cA:undetectable | 4a6eA-2o3cA:20.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2og9 | MANDELATERACEMASE/MUCONATELACTONIZING ENZYME (Polaromonas sp.JS666) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 5 | GLY A 293GLY A 120ILE A 295VAL A 124ASP A 288 | None | 1.13A | 4a6eA-2og9A:undetectable | 4a6eA-2og9A:23.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2q27 | OXALYL-COADECARBOXYLASE (Escherichiacoli) |
PF00205(TPP_enzyme_M)PF02775(TPP_enzyme_C)PF02776(TPP_enzyme_N) | 5 | LEU A 415GLY A 428GLY A 426ILE A 460PHE A 51 | None | 1.08A | 4a6eA-2q27A:3.1 | 4a6eA-2q27A:20.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qm1 | GLUCOKINASE (Enterococcusfaecalis) |
PF00480(ROK) | 5 | GLY A 267GLY A 140ILE A 137VAL A 143ALA A 271 | None | 1.16A | 4a6eA-2qm1A:undetectable | 4a6eA-2qm1A:20.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qyo | O-METHYLTRANSFERASE (Medicagotruncatula) |
PF00891(Methyltransf_2)PF08100(Dimerisation) | 5 | GLY A 201GLY A 203VAL A 228ASP A 263TRP A 264 | SAH A 601 (-3.7A)SAH A 601 ( 3.8A)SAH A 601 ( 4.9A)QSO A 701 (-3.9A)None | 0.62A | 4a6eA-2qyoA:23.7 | 4a6eA-2qyoA:28.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3a5r | BENZALACETONESYNTHASE (Rheum palmatum) |
PF00195(Chal_sti_synt_N)PF02797(Chal_sti_synt_C) | 5 | GLY A 365ILE A 294VAL A 335ALA A 236ARG A 165 | None | 1.15A | 4a6eA-3a5rA:undetectable | 4a6eA-3a5rA:21.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3c3y | O-METHYLTRANSFERASE (Mesembryanthemumcrystallinum) |
PF01596(Methyltransf_3) | 5 | PHE A 126GLY A 82GLY A 111ILE A 124ASP A 102 | NoneSAH A 464 ( 4.6A)NoneNoneSAH A 464 (-2.8A) | 1.01A | 4a6eA-3c3yA:11.1 | 4a6eA-3c3yA:21.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ec4 | PUTATIVEACETYLTRANSFERASEFROM THE GNAT FAMILY (Novosphingobiumaromaticivorans) |
PF08445(FR47) | 5 | LEU A 103GLY A 161GLY A 147ILE A 178VAL A 181 | None | 1.11A | 4a6eA-3ec4A:undetectable | 4a6eA-3ec4A:24.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gxo | MMCR (Streptomyceslavendulae) |
PF00891(Methyltransf_2) | 6 | GLY A 190GLY A 192VAL A 217PHE A 241ASP A 260TRP A 261 | SAH A 350 (-4.1A)SAH A 350 (-3.6A)SAH A 350 ( 4.7A)SAH A 350 (-3.6A)MQA A 351 (-2.8A)None | 0.62A | 4a6eA-3gxoA:33.5 | 4a6eA-3gxoA:27.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3i58 | O-METHYLTRANSFERASE (Streptomycescarzinostaticus) |
PF00891(Methyltransf_2) | 5 | GLY A 177GLY A 179PHE A 228ASP A 247TRP A 248 | SAH A 401 (-3.9A)SAH A 401 (-3.6A)SAH A 401 (-3.4A)SAH A 401 (-4.6A)None | 0.69A | 4a6eA-3i58A:29.4 | 4a6eA-3i58A:27.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3i9f | PUTATIVE TYPE 11METHYLTRANSFERASE (Sulfolobussolfataricus) |
PF08241(Methyltransf_11) | 5 | GLY A 39GLY A 41ILE A 61ALA A 96ASP A 101 | None | 1.12A | 4a6eA-3i9fA:11.9 | 4a6eA-3i9fA:19.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3iwg | ACETYLTRANSFERASE,GNAT FAMILY (Colwelliapsychrerythraea) |
PF00583(Acetyltransf_1) | 5 | GLY A 181GLY A 192ILE A 138VAL A 224ALA A 143 | NoneNone CL A 603 (-4.3A)NoneNone | 1.17A | 4a6eA-3iwgA:undetectable | 4a6eA-3iwgA:21.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3krs | TRIOSEPHOSPHATEISOMERASE (Cryptosporidiumparvum) |
PF00121(TIM) | 5 | PHE A 61GLY A 9GLY A 8PHE A 11ALA A 236 | None | 1.09A | 4a6eA-3krsA:undetectable | 4a6eA-3krsA:20.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kv1 | TRANSCRIPTIONALREPRESSOR (Aliivibriofischeri) |
PF04198(Sugar-bind) | 5 | GLY A 188GLY A 59ILE A 186VAL A 151ALA A 119 | GOL A 271 (-3.7A)NoneNoneNoneNone | 1.13A | 4a6eA-3kv1A:undetectable | 4a6eA-3kv1A:21.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lst | CALO1METHYLTRANSFERASE (Micromonosporaechinospora) |
PF00891(Methyltransf_2) | 5 | GLY A 189GLY A 191VAL A 216PHE A 238TRP A 257 | SAH A 346 (-4.0A)SAH A 346 ( 3.7A)NoneSAH A 346 (-3.4A)None | 0.75A | 4a6eA-3lstA:28.3 | 4a6eA-3lstA:26.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3n29 | CARBOXYNORSPERMIDINEDECARBOXYLASE (Campylobacterjejuni) |
PF00278(Orn_DAP_Arg_deC) | 5 | LEU A 38GLY A 42ILE A 344VAL A 345ALA A 237 | None | 1.05A | 4a6eA-3n29A:undetectable | 4a6eA-3n29A:23.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pv2 | DEGQ (Legionellafallonii) |
PF13180(PDZ_2)PF13365(Trypsin_2) | 5 | GLY A 194GLY A 67VAL A 23ALA A 210ASP A 114 | None | 1.00A | 4a6eA-3pv2A:undetectable | 4a6eA-3pv2A:22.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3q2k | OXIDOREDUCTASE (Bordetellapertussis) |
PF01408(GFO_IDH_MocA)PF02894(GFO_IDH_MocA_C) | 5 | GLY A 259GLY A 151ILE A 254ALA A 277TRP A 274 | None | 1.15A | 4a6eA-3q2kA:4.6 | 4a6eA-3q2kA:22.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3sg1 | UDP-N-ACETYLGLUCOSAMINE1-CARBOXYVINYLTRANSFERASE 1 (Bacillusanthracis) |
PF00275(EPSP_synthase) | 5 | PHE A 403GLY A 381ILE A 4VAL A 6ALA A 313 | None | 1.03A | 4a6eA-3sg1A:undetectable | 4a6eA-3sg1A:24.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3sti | PROTEASE DEGQ (Escherichiacoli) |
PF13365(Trypsin_2) | 5 | GLY A 188GLY A 65VAL A 29ALA A 204ASP A 112 | None | 1.04A | 4a6eA-3stiA:undetectable | 4a6eA-3stiA:19.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3v7i | PUTATIVE POLYKETIDESYNTHASE (Streptomycescoelicolor) |
PF00195(Chal_sti_synt_N) | 5 | LEU A 389TRP A 388GLY A 367ALA A 370ASP A 247 | None | 1.12A | 4a6eA-3v7iA:undetectable | 4a6eA-3v7iA:22.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wcs | ERYTHROAGGLUTININ (Phaseolusvulgaris) |
PF00139(Lectin_legB) | 5 | PHE A 89GLY A 229ILE A 76VAL A 226ALA A 110 | NoneNoneEDO A1009 (-4.2A)NoneNone | 1.14A | 4a6eA-3wcsA:undetectable | 4a6eA-3wcsA:20.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wxr | PROBABLE PROTEASOMESUBUNIT ALPHA TYPE-7 (Saccharomycescerevisiae) |
PF00227(Proteasome)PF10584(Proteasome_A_N) | 5 | PHE G 137LEU G 87GLY G 91ILE G 73VAL G 69 | None | 1.10A | 4a6eA-3wxrG:undetectable | 4a6eA-3wxrG:23.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3zdn | MONOAMINE OXIDASE N (Aspergillusniger) |
PF01593(Amino_oxidase) | 5 | GLY A 47GLY A 51VAL A 44PHE A 275ALA A 258 | FAD A1487 (-4.2A)NoneNoneNoneNone | 1.17A | 4a6eA-3zdnA:undetectable | 4a6eA-3zdnA:21.05 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4a6e | HYDROXYINDOLEO-METHYLTRANSFERASE (Homo sapiens) |
PF00891(Methyltransf_2)PF16864(Dimerisation2) | 5 | LEU A 160GLY A 188VAL A 214ALA A 251ARG A 252 | SAM A1349 (-4.1A)SAM A1349 ( 4.0A)SAM A1349 (-4.9A)SAM A1349 (-3.7A)SAM A1349 ( 3.8A) | 1.14A | 4a6eA-4a6eA:55.0 | 4a6eA-4a6eA:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4a6e | HYDROXYINDOLEO-METHYLTRANSFERASE (Homo sapiens) |
PF00891(Methyltransf_2)PF16864(Dimerisation2) | 12 | PHE A 143LEU A 160TRP A 164GLY A 187GLY A 189ILE A 211VAL A 214PHE A 237ALA A 251ARG A 252ASP A 256TRP A 257 | SAM A1349 (-3.8A)SAM A1349 (-4.1A)SAM A1349 (-4.2A)SAM A1349 (-3.6A)SAM A1349 ( 3.8A)SAM A1349 (-4.6A)SAM A1349 (-4.9A)SAM A1349 (-3.5A)SAM A1349 (-3.7A)SAM A1349 ( 3.8A)ASE A1350 ( 2.9A)None | 0.02A | 4a6eA-4a6eA:55.0 | 4a6eA-4a6eA:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4a6e | HYDROXYINDOLEO-METHYLTRANSFERASE (Homo sapiens) |
PF00891(Methyltransf_2)PF16864(Dimerisation2) | 9 | PHE A 143LEU A 160TRP A 164GLY A 188ILE A 211PHE A 237ARG A 252ASP A 256TRP A 257 | SAM A1349 (-3.8A)SAM A1349 (-4.1A)SAM A1349 (-4.2A)SAM A1349 ( 4.0A)SAM A1349 (-4.6A)SAM A1349 (-3.5A)SAM A1349 ( 3.8A)ASE A1350 ( 2.9A)None | 0.94A | 4a6eA-4a6eA:55.0 | 4a6eA-4a6eA:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4c7v | TRANSKETOLASE (Lactobacillussalivarius) |
PF00456(Transketolase_N)PF02779(Transket_pyr)PF02780(Transketolase_C) | 5 | LEU A 224GLY A 221ILE A 244VAL A 218ALA A 36 | None | 1.14A | 4a6eA-4c7vA:3.5 | 4a6eA-4c7vA:19.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4dzh | AMIDOHYDROLASE (Xanthomonascampestris) |
PF01979(Amidohydro_1) | 5 | PHE A 154GLY A 73ILE A 414VAL A 412ALA A 355 | None | 1.04A | 4a6eA-4dzhA:undetectable | 4a6eA-4dzhA:22.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4evi | CONIFERYL ALCOHOL9-O-METHYLTRANSFERASE (Linumnodiflorum) |
PF00891(Methyltransf_2)PF08100(Dimerisation) | 5 | GLY A 208GLY A 210VAL A 235ASP A 272TRP A 273 | SAH A 401 (-3.6A)SAH A 401 ( 3.8A)SAH A 401 (-4.8A)C9M A 402 ( 2.3A)None | 0.29A | 4a6eA-4eviA:34.0 | 4a6eA-4eviA:27.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4g4i | 4-O-METHYL-GLUCURONOYL METHYLESTERASE (Thermothelomycesthermophila) |
no annotation | 5 | GLY A 211GLY A 132ILE A 128ALA A 213ARG A 214 | NoneNoneNoneEDO A 506 ( 4.1A)EDO A 506 (-3.6A) | 1.02A | 4a6eA-4g4iA:undetectable | 4a6eA-4g4iA:22.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hds | ARSA (Sporomusa ovata) |
PF02277(DBI_PRT) | 5 | GLY A 250GLY A 254ILE A 160VAL A 161ALA A 276 | None | 1.02A | 4a6eA-4hdsA:undetectable | 4a6eA-4hdsA:22.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hu8 | GH10 XYLANASE (Globitermesbrachycerastes) |
PF00331(Glyco_hydro_10)PF02368(Big_2) | 5 | GLY A 441GLY A 387ILE A 397ALA A 390ASP A 394 | None | 1.06A | 4a6eA-4hu8A:undetectable | 4a6eA-4hu8A:20.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jot | ENOYL-COA HYDRATASE,PUTATIVE (Deinococcusradiodurans) |
PF00378(ECH_1) | 5 | PHE A 44GLY A 121PHE A 65ALA A 126ARG A 157 | None | 1.10A | 4a6eA-4jotA:undetectable | 4a6eA-4jotA:23.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4m3c | LECTIN BETA CHAIN (Buteamonosperma) |
PF00139(Lectin_legB) | 5 | PHE B 70GLY B 211ILE B 57VAL B 208ALA B 91 | NoneNoneABU B 303 (-3.7A)NoneNone | 1.11A | 4a6eA-4m3cB:undetectable | 4a6eA-4m3cB:19.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mo2 | UDP-GALACTOPYRANOSEMUTASE (Campylobacterjejuni) |
no annotation | 5 | PHE B 100LEU B 146GLY B 139ILE B 115ALA B 134 | None | 1.13A | 4a6eA-4mo2B:2.4 | 4a6eA-4mo2B:18.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ntd | THIOREDOXINREDUCTASE (Streptomycesclavuligerus) |
PF07992(Pyr_redox_2) | 5 | PHE A 79LEU A 25GLY A 17GLY A 20VAL A 13 | NoneNoneFAD A 402 (-3.5A)NoneNone | 1.12A | 4a6eA-4ntdA:undetectable | 4a6eA-4ntdA:22.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4otd | SERINE/THREONINE-PROTEIN KINASE N1 (Homo sapiens) |
PF00069(Pkinase)PF00433(Pkinase_C) | 5 | GLY A 773GLY A 771ARG A 745ASP A 803TRP A 804 | NoneNoneTPO A 780 ( 2.8A)NoneNone | 1.09A | 4a6eA-4otdA:undetectable | 4a6eA-4otdA:23.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4pgh | CAFFEIC ACIDO-METHYLTRANSFERASE (Sorghum bicolor) |
PF00891(Methyltransf_2)PF08100(Dimerisation) | 5 | GLY A 206GLY A 208VAL A 233ASP A 268TRP A 269 | SAM A 401 (-3.8A)SAM A 401 ( 4.1A)SAM A 401 ( 4.9A)NoneNone | 0.63A | 4a6eA-4pghA:30.7 | 4a6eA-4pghA:26.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rep | GAMMA-CAROTENEDESATURASE (Nonlabensdokdonensis) |
PF01593(Amino_oxidase) | 5 | PHE A 241LEU A 18GLY A 10GLY A 13VAL A 6 | NoneNoneFAD A 501 (-3.4A)NoneNone | 0.96A | 4a6eA-4repA:3.2 | 4a6eA-4repA:21.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rnc | ESTERASE (Rhodococcus sp.ECU1013) |
PF12697(Abhydrolase_6) | 5 | GLY A 80ILE A 14VAL A 85ALA A 113TRP A 78 | None | 1.09A | 4a6eA-4rncA:undetectable | 4a6eA-4rncA:23.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4s3k | SPORE GERMINATIONPROTEIN YAAH (Bacillusmegaterium) |
PF00704(Glyco_hydro_18)PF01476(LysM) | 5 | TRP A 407GLY A 136GLY A 108PHE A 167ALA A 138 | None | 1.07A | 4a6eA-4s3kA:undetectable | 4a6eA-4s3kA:21.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4u36 | SEED LECTIN (Vataireamacrocarpa) |
PF00139(Lectin_legB) | 5 | PHE A 69GLY A 206ILE A 56VAL A 203ALA A 90 | None | 1.10A | 4a6eA-4u36A:undetectable | 4a6eA-4u36A:19.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ykn | PHOSPHATIDYLINOSITOL3-KINASE REGULATORYSUBUNITALPHA,PHOSPHATIDYLINOSITOL4,5-BISPHOSPHATE3-KINASE CATALYTICSUBUNIT ALPHAISOFORM FUSIONPROTEIN (Homo sapiens) |
PF00017(SH2)PF00454(PI3_PI4_kinase)PF00613(PI3Ka)PF00792(PI3K_C2)PF00794(PI3K_rbd)PF02192(PI3K_p85B)PF16454(PI3K_P85_iSH2) | 5 | PHE A2016LEU A1570TRP A1574GLY A1364ASP A1603 | None | 1.01A | 4a6eA-4yknA:undetectable | 4a6eA-4yknA:13.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ysh | GLYCINE OXIDASE (Geobacilluskaustophilus) |
PF01266(DAO) | 5 | LEU A 367GLY A 216ILE A 183VAL A 219ALA A 332 | None | 1.04A | 4a6eA-4yshA:2.3 | 4a6eA-4yshA:22.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5awp | ISOMALTODEXTRANASE (Arthrobacterglobiformis) |
no annotation | 5 | LEU A 584GLY A 303GLY A 305ILE A 308ALA A 477 | None | 1.14A | 4a6eA-5awpA:undetectable | 4a6eA-5awpA:20.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5cvv | (ISO)EUGENOLO-METHYLTRANSFERASE (Clarkia breweri) |
PF00891(Methyltransf_2)PF08100(Dimerisation) | 5 | GLY A 211GLY A 213VAL A 238ASP A 273TRP A 274 | SAH A 401 (-3.8A)SAH A 401 ( 3.7A)NoneN7I A 402 ( 2.7A)None | 0.39A | 4a6eA-5cvvA:35.2 | 4a6eA-5cvvA:25.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5elp | NRPS/PKS PROTEIN (Bacillusamyloliquefaciens) |
no annotation | 5 | LEU C 185ILE C 17VAL C 251PHE C 30ALA C 362 | None | 1.12A | 4a6eA-5elpC:undetectable | 4a6eA-5elpC:20.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5h5l | GLUTATHIONES-TRANSFERASE S2 (Nilaparvatalugens) |
PF02798(GST_N)PF14497(GST_C_3) | 5 | PHE A 29GLY A 15ALA A 12ARG A 197ASP A 31 | None | 1.14A | 4a6eA-5h5lA:undetectable | 4a6eA-5h5lA:17.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hj7 | GLUTAMATE RACEMASE (Mycobacteriumtuberculosis) |
PF01177(Asp_Glu_race) | 5 | PHE A 148LEU A 181GLY A 118GLY A 184ALA A 142 | None | 1.10A | 4a6eA-5hj7A:undetectable | 4a6eA-5hj7A:20.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5i2h | O-METHYLTRANSFERASEFAMILY 2 (Planctopiruslimnophila) |
PF00891(Methyltransf_2)PF16864(Dimerisation2) | 5 | LEU A 162GLY A 202VAL A 228ASP A 271TRP A 272 | NoneNoneNoneAGI A 501 (-2.4A)None | 0.81A | 4a6eA-5i2hA:22.0 | 4a6eA-5i2hA:27.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5i2h | O-METHYLTRANSFERASEFAMILY 2 (Planctopiruslimnophila) |
PF00891(Methyltransf_2)PF16864(Dimerisation2) | 5 | LEU A 162GLY A 203VAL A 228ASP A 271TRP A 272 | NoneNoneNoneAGI A 501 (-2.4A)None | 0.71A | 4a6eA-5i2hA:22.0 | 4a6eA-5i2hA:27.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5i70 | PLASMEPSIN IV (Plasmodiumfalciparum) |
no annotation | 5 | LEU B 191GLY B 36ILE B 300VAL B 212ALA B 38 | None | 0.90A | 4a6eA-5i70B:undetectable | 4a6eA-5i70B:19.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5icl | LIPOATE--PROTEINLIGASE (Enterococcusfaecalis) |
PF03099(BPL_LplA_LipB)PF10437(Lip_prot_lig_C) | 5 | PHE A 84LEU A 125ILE A 209PHE A -2ALA A 99 | None | 1.08A | 4a6eA-5iclA:undetectable | 4a6eA-5iclA:21.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jfc | NADH-DEPENDENTFERREDOXIN:NADPOXIDOREDUCTASESUBUNIT ALPHA (Pyrococcusfuriosus) |
PF07992(Pyr_redox_2)PF14691(Fer4_20) | 5 | GLY L 246GLY L 248ILE L 446PHE L 244ALA L 162 | NoneFAD L 503 (-3.1A)NoneNoneNone | 0.92A | 4a6eA-5jfcL:3.2 | 4a6eA-5jfcL:21.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jia | RAN-BINDING PROTEIN10 (Mus musculus) |
PF00622(SPRY) | 5 | LEU A 132GLY A 121GLY A 141ILE A 169PHE A 105 | None | 1.12A | 4a6eA-5jiaA:undetectable | 4a6eA-5jiaA:20.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jiu | RAN-BINDING PROTEIN9 (Homo sapiens) |
PF00622(SPRY) | 5 | LEU A 244GLY A 233GLY A 253ILE A 281PHE A 217 | None | 1.13A | 4a6eA-5jiuA:undetectable | 4a6eA-5jiuA:24.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jlt | MIDDLE TRANSCRIPTIONREGULATORY PROTEINMOTA (Escherichiavirus T4) |
PF09158(MotCF) | 5 | PHE A 175GLY A 148GLY A 164ILE A 172VAL A 190 | None | 1.14A | 4a6eA-5jltA:undetectable | 4a6eA-5jltA:17.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jr3 | CARMINOMYCIN4-O-METHYLTRANSFERASE DNRK (Streptomycespeucetius) |
PF00891(Methyltransf_2) | 5 | LEU A 160GLY A 187GLY A 189PHE A 238TRP A 258 | SAH A 401 (-4.1A)SAH A 401 (-3.9A)SAH A 401 ( 3.8A)SAH A 401 (-3.4A)None | 0.66A | 4a6eA-5jr3A:32.2 | 4a6eA-5jr3A:29.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5kva | CAFFEOYL-COAO-METHYLTRANSFERASE (Sorghum bicolor) |
PF01596(Methyltransf_3) | 5 | PHE A 149GLY A 105GLY A 134ILE A 147ASP A 125 | NoneSAM A 301 ( 4.8A)NoneNoneSAM A 301 (-2.8A) | 1.00A | 4a6eA-5kvaA:11.3 | 4a6eA-5kvaA:22.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5kxb | WISTERIA FLORIBUNDAAGGLUTININ (Wisteriafloribunda) |
PF00139(Lectin_legB) | 5 | PHE A 99GLY A 238ILE A 86VAL A 235ALA A 120 | None | 1.11A | 4a6eA-5kxbA:undetectable | 4a6eA-5kxbA:17.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5l10 | N-ACYLHOMOSERINELACTONE DEPENDENTREGULATORY PROTEIN (Burkholderiacenocepacia) |
PF03472(Autoind_bind) | 5 | GLY A 127GLY A 118ILE A 79VAL A 82ALA A 157 | None | 1.17A | 4a6eA-5l10A:undetectable | 4a6eA-5l10A:20.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5lf7 | PROTEASOME SUBUNITBETA TYPE-1 (Homo sapiens) |
PF00227(Proteasome) | 5 | LEU L 46GLY L 111ILE L 12VAL L 23ALA L 89 | None | 1.05A | 4a6eA-5lf7L:undetectable | 4a6eA-5lf7L:21.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vj4 | UNCHARACTERIZEDPROTEIN (Borreliaturicatae) |
no annotation | 5 | LEU A 230GLY A 234ILE A 240PHE A 294ALA A 288 | None | 1.11A | 4a6eA-5vj4A:undetectable | 4a6eA-5vj4A:21.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vj7 | OXIDOREDUCTASE (Pyrococcusfuriosus) |
PF07992(Pyr_redox_2)PF14691(Fer4_20) | 5 | GLY A 246GLY A 248ILE A 447PHE A 244ALA A 162 | NoneFAD A 503 (-3.1A)NoneNoneFAD A 503 (-4.8A) | 0.94A | 4a6eA-5vj7A:2.8 | 4a6eA-5vj7A:20.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vyl | INNER TEGUMENTPROTEIN (Humanalphaherpesvirus1) |
PF03970(Herpes_UL37_1) | 5 | LEU A 224GLY A 112ILE A 140VAL A 115ALA A 161 | None | 1.04A | 4a6eA-5vylA:undetectable | 4a6eA-5vylA:21.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5w16 | GLUTAMATE RACEMASE (Thermusthermophilus) |
no annotation | 5 | PHE A 140LEU A 172GLY A 115GLY A 175ALA A 134 | None | 1.09A | 4a6eA-5w16A:undetectable | 4a6eA-5w16A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5w7p | OXAC (Penicilliumoxalicum) |
no annotation | 6 | PHE A 194GLY A 244PHE A 293ARG A 310ASP A 314TRP A 315 | SAM A 501 (-3.7A)SAM A 501 ( 3.8A)SAM A 501 (-3.3A)SAM A 501 (-4.1A)SAM A 501 ( 4.2A)None | 1.13A | 4a6eA-5w7pA:29.0 | 4a6eA-5w7pA:25.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5w7p | OXAC (Penicilliumoxalicum) |
no annotation | 6 | PHE A 194VAL A 273PHE A 293ARG A 310ASP A 314TRP A 315 | SAM A 501 (-3.7A)SAM A 501 (-4.8A)SAM A 501 (-3.3A)SAM A 501 (-4.1A)SAM A 501 ( 4.2A)None | 0.61A | 4a6eA-5w7pA:29.0 | 4a6eA-5w7pA:25.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wjc | KINETOCHORE PROTEINMIS16 (Schizosaccharomycespombe) |
no annotation | 6 | TRP A 210GLY A 185GLY A 201ILE A 237VAL A 238ALA A 156 | None | 1.35A | 4a6eA-5wjcA:undetectable | 4a6eA-5wjcA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5x1n | VANILLATE/3-O-METHYLGALLATEO-DEMETHYLASE (Sphingobium sp.SYK-6) |
PF01571(GCV_T)PF08669(GCV_T_C) | 5 | GLY A 101ILE A 80VAL A 97PHE A 315ALA A 327 | None | 1.08A | 4a6eA-5x1nA:undetectable | 4a6eA-5x1nA:20.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5x8o | INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE (Trypanosomabrucei) |
no annotation | 5 | LEU A 230GLY A 73ILE A 349VAL A 50ALA A 253 | None | 1.12A | 4a6eA-5x8oA:undetectable | 4a6eA-5x8oA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xgj | PHOSPHATIDYLINOSITOL4,5-BISPHOSPHATE3-KINASE CATALYTICSUBUNIT ALPHAISOFORM (Homo sapiens) |
no annotation | 5 | PHE A1016LEU A 570TRP A 574GLY A 364ASP A 603 | None | 1.01A | 4a6eA-5xgjA:undetectable | 4a6eA-5xgjA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xoh | BERGAPTOLO-METHYLTRANSFERASE (Peucedanumpraeruptorum) |
no annotation | 5 | PHE A 158GLY A 203GLY A 205VAL A 230TRP A 266 | SAH A 401 ( 3.6A)SAH A 401 (-3.4A)SAH A 401 ( 3.7A)NoneNone | 0.55A | 4a6eA-5xohA:33.3 | 4a6eA-5xohA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5yal | ESTERASE (Streptomycescinnamoneus) |
no annotation | 5 | GLY A 267GLY A 294PHE A 271ALA A 265ASP A 262 | None | 0.93A | 4a6eA-5yalA:undetectable | 4a6eA-5yalA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5yo8 | TETRAPRENYL-BETA-CURCUMENE SYNTHASE (Bacillusalcalophilus) |
no annotation | 5 | LEU A 64GLY A 58GLY A 60VAL A 22PHE A 54 | None | 1.02A | 4a6eA-5yo8A:undetectable | 4a6eA-5yo8A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6c5b | METHYLTRANSFERASE (Lysobacterantibioticus) |
no annotation | 7 | PHE A 138GLY A 182GLY A 184VAL A 209PHE A 233ASP A 252TRP A 253 | SAH A 501 ( 3.9A)SAH A 501 (-4.0A)SAH A 501 (-3.3A)SAH A 501 ( 4.9A)SAH A 501 (-3.5A)SAH A 501 (-4.0A)None | 0.58A | 4a6eA-6c5bA:35.8 | 4a6eA-6c5bA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6cmz | DIHYDROLIPOYLDEHYDROGENASE (Burkholderiacenocepacia) |
no annotation | 5 | LEU A 266GLY A 191ILE A 55VAL A 193ALA A 183 | None | 1.12A | 4a6eA-6cmzA:2.8 | 4a6eA-6cmzA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6fn1 | HUMAN-MOUSE CHIMERICABCB1 (ABCBHM) (Homo sapiens) |
no annotation | 5 | PHE A 696GLY A 829GLY A 826ILE A 699ALA A 833 | None | 1.12A | 4a6eA-6fn1A:undetectable | 4a6eA-6fn1A:undetectable |