SIMILAR PATTERNS OF AMINO ACIDS FOR 4A6E_A_SAMA1349

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ahi 7
ALPHA-HYDROXYSTEROID
DEHYDROGENASE

(Escherichia
coli) 		PF13561
(adh_short_C2) 		5 GLY A  24
GLY A  20
ILE A  29
VAL A  51
ALA A  96
 None
NAI  A 302 ( 4.1A)
None
None
NAI  A 302 ( 4.3A)
 1.17A 4a6eA-1ahiA:
4.4		 4a6eA-1ahiA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1avb ARCELIN-1

(Phaseolus
vulgaris) 		PF00139
(Lectin_legB) 		5 PHE A  65
GLY A 199
ILE A  52
VAL A 196
ALA A  86
 None
 1.08A 4a6eA-1avbA:
undetectable		 4a6eA-1avbA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c0i D-AMINO ACID OXIDASE

(Rhodotorula
toruloides) 		PF01266
(DAO) 		5 PHE A1157
LEU A1021
GLY A1013
GLY A1016
VAL A1009
 None
None
FAD  A1363 (-3.3A)
None
None
 1.13A 4a6eA-1c0iA:
undetectable		 4a6eA-1c0iA:
24.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ioa ARCELIN-5A

(Phaseolus
vulgaris) 		PF00139
(Lectin_legB) 		5 PHE A  67
GLY A 201
ILE A  56
VAL A 198
ALA A  88
 None
 1.00A 4a6eA-1ioaA:
undetectable		 4a6eA-1ioaA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k1x 4-ALPHA-GLUCANOTRANS
FERASE

(Thermococcus
litoralis) 		PF03065
(Glyco_hydro_57)
PF09094
(DUF1925)
PF09095
(DUF1926) 		5 GLY A   9
ILE A 177
VAL A 143
PHE A 211
ASP A 214
 None
 1.16A 4a6eA-1k1xA:
undetectable		 4a6eA-1k1xA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kc8 RIBOSOMAL PROTEIN
L21E

(Haloarcula
marismortui) 		PF01157
(Ribosomal_L21e) 		5 PHE R  52
GLY R  61
ILE R  84
VAL R  73
ASP R  57
 None
 1.14A 4a6eA-1kc8R:
undetectable		 4a6eA-1kc8R:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o5t TRYPTOPHANYL-TRNA
SYNTHETASE

(Homo sapiens) 		PF00579
(tRNA-synt_1b) 		5 PHE A 280
GLY A 163
GLY A 161
ALA A 215
ASP A 198
 None
 1.14A 4a6eA-1o5tA:
undetectable		 4a6eA-1o5tA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tkc TRANSKETOLASE

(Saccharomyces
cerevisiae) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		5 LEU A 224
GLY A 220
ILE A 244
VAL A 217
ALA A  38
 None
 1.02A 4a6eA-1tkcA:
2.9		 4a6eA-1tkcA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tz6 PUTATIVE SUGAR
KINASE

(Salmonella
enterica) 		PF00294
(PfkB) 		5 LEU A  53
GLY A  11
GLY A  51
VAL A 111
ALA A  34
 None
 1.16A 4a6eA-1tz6A:
3.2		 4a6eA-1tz6A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uan HYPOTHETICAL PROTEIN
TT1542

(Thermus
thermophilus) 		PF02585
(PIG-L) 		5 PHE A 213
GLY A  19
GLY A  14
VAL A   6
ARG A 194
 None
 1.03A 4a6eA-1uanA:
2.6		 4a6eA-1uanA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uc8 LYSINE BIOSYNTHESIS
ENZYME

(Thermus
thermophilus) 		PF08443
(RimK) 		5 PHE A 256
LEU A  53
GLY A 269
VAL A 184
ALA A  20
 None
 1.14A 4a6eA-1uc8A:
undetectable		 4a6eA-1uc8A:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wy6 HYPOTHETICAL PROTEIN
ST1625

(Sulfurisphaera
tokodaii) 		PF09205
(DUF1955) 		5 PHE A  46
LEU A  20
GLY A  27
ILE A  66
VAL A  62
 None
 0.93A 4a6eA-1wy6A:
undetectable		 4a6eA-1wy6A:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wzz PROBABLE
ENDOGLUCANASE

(Komagataeibacter
xylinus) 		PF01270
(Glyco_hydro_8) 		5 PHE A  65
GLY A  60
GLY A  58
VAL A  45
ARG A 248
 None
 1.00A 4a6eA-1wzzA:
undetectable		 4a6eA-1wzzA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ys9 PROTEIN SPY1043

(Streptococcus
pyogenes) 		PF13242
(Hydrolase_like)
PF13344
(Hydrolase_6) 		5 PHE A 142
GLY A 119
ILE A 143
PHE A 178
ALA A 163
 None
 1.14A 4a6eA-1ys9A:
undetectable		 4a6eA-1ys9A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c7z 3-KETOACYL-COA
THIOLASE 2

(Arabidopsis
thaliana) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		5 GLY A 297
GLY A 299
VAL A  82
PHE A  70
ASP A 261
 None
 1.01A 4a6eA-2c7zA:
undetectable		 4a6eA-2c7zA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d3a GLUTAMINE SYNTHETASE

(Zea mays) 		PF00120
(Gln-synt_C)
PF03951
(Gln-synt_N) 		5 GLY A  61
GLY A  57
ILE A 102
VAL A  70
ASP A  32
 None
 1.14A 4a6eA-2d3aA:
undetectable		 4a6eA-2d3aA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dr3 UPF0273 PROTEIN
PH0284

(Pyrococcus
horikoshii) 		PF06745
(ATPase) 		5 PHE A  39
LEU A  16
GLY A  11
ILE A 231
VAL A 233
 None
 0.97A 4a6eA-2dr3A:
undetectable		 4a6eA-2dr3A:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g28 PYRUVATE
DEHYDROGENASE E1
COMPONENT

(Escherichia
coli) 		PF00456
(Transketolase_N) 		6 GLY A 363
ILE A 386
VAL A 292
PHE A 227
ALA A 114
ARG A  82
 None
 1.07A 4a6eA-2g28A:
undetectable		 4a6eA-2g28A:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gh9 MALTOSE/MALTODEXTRIN
-BINDING PROTEIN

(Thermus
thermophilus) 		PF13416
(SBP_bac_8) 		5 LEU A 185
GLY A 192
GLY A 189
ILE A 366
ALA A 168
 None
 1.16A 4a6eA-2gh9A:
undetectable		 4a6eA-2gh9A:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ji9 OXALYL-COA
DECARBOXYLASE

(Oxalobacter
formigenes) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		5 LEU A 420
GLY A 433
GLY A 431
ILE A 465
PHE A  53
 None
 1.00A 4a6eA-2ji9A:
3.3		 4a6eA-2ji9A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o0x 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE

(Mycobacterium
tuberculosis) 		PF00275
(EPSP_synthase) 		5 PHE A 415
LEU A 395
GLY A 390
ILE A 405
ALA A 318
 None
 1.09A 4a6eA-2o0xA:
undetectable		 4a6eA-2o0xA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o3c APEX NUCLEASE 1

(Danio rerio) 		PF03372
(Exo_endo_phos) 		5 LEU A  65
GLY A 114
GLY A 123
ILE A 151
ALA A  93
 None
 0.98A 4a6eA-2o3cA:
undetectable		 4a6eA-2o3cA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2og9 MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME

(Polaromonas sp.
JS666) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 GLY A 293
GLY A 120
ILE A 295
VAL A 124
ASP A 288
 None
 1.13A 4a6eA-2og9A:
undetectable		 4a6eA-2og9A:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q27 OXALYL-COA
DECARBOXYLASE

(Escherichia
coli) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		5 LEU A 415
GLY A 428
GLY A 426
ILE A 460
PHE A  51
 None
 1.08A 4a6eA-2q27A:
3.1		 4a6eA-2q27A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qm1 GLUCOKINASE

(Enterococcus
faecalis) 		PF00480
(ROK) 		5 GLY A 267
GLY A 140
ILE A 137
VAL A 143
ALA A 271
 None
 1.16A 4a6eA-2qm1A:
undetectable		 4a6eA-2qm1A:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qyo O-METHYLTRANSFERASE

(Medicago
truncatula) 		PF00891
(Methyltransf_2)
PF08100
(Dimerisation) 		5 GLY A 201
GLY A 203
VAL A 228
ASP A 263
TRP A 264
 SAH  A 601 (-3.7A)
SAH  A 601 ( 3.8A)
SAH  A 601 ( 4.9A)
QSO  A 701 (-3.9A)
None
 0.62A 4a6eA-2qyoA:
23.7		 4a6eA-2qyoA:
28.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a5r BENZALACETONE
SYNTHASE

(Rheum palmatum) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		5 GLY A 365
ILE A 294
VAL A 335
ALA A 236
ARG A 165
 None
 1.15A 4a6eA-3a5rA:
undetectable		 4a6eA-3a5rA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c3y O-METHYLTRANSFERASE

(Mesembryanthemum
crystallinum) 		PF01596
(Methyltransf_3) 		5 PHE A 126
GLY A  82
GLY A 111
ILE A 124
ASP A 102
 None
SAH  A 464 ( 4.6A)
None
None
SAH  A 464 (-2.8A)
 1.01A 4a6eA-3c3yA:
11.1		 4a6eA-3c3yA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ec4 PUTATIVE
ACETYLTRANSFERASE
FROM THE GNAT FAMILY

(Novosphingobium
aromaticivorans) 		PF08445
(FR47) 		5 LEU A 103
GLY A 161
GLY A 147
ILE A 178
VAL A 181
 None
 1.11A 4a6eA-3ec4A:
undetectable		 4a6eA-3ec4A:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gxo MMCR

(Streptomyces
lavendulae) 		PF00891
(Methyltransf_2) 		6 GLY A 190
GLY A 192
VAL A 217
PHE A 241
ASP A 260
TRP A 261
 SAH  A 350 (-4.1A)
SAH  A 350 (-3.6A)
SAH  A 350 ( 4.7A)
SAH  A 350 (-3.6A)
MQA  A 351 (-2.8A)
None
 0.62A 4a6eA-3gxoA:
33.5		 4a6eA-3gxoA:
27.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i58 O-METHYLTRANSFERASE

(Streptomyces
carzinostaticus) 		PF00891
(Methyltransf_2) 		5 GLY A 177
GLY A 179
PHE A 228
ASP A 247
TRP A 248
 SAH  A 401 (-3.9A)
SAH  A 401 (-3.6A)
SAH  A 401 (-3.4A)
SAH  A 401 (-4.6A)
None
 0.69A 4a6eA-3i58A:
29.4		 4a6eA-3i58A:
27.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i9f PUTATIVE TYPE 11
METHYLTRANSFERASE

(Sulfolobus
solfataricus) 		PF08241
(Methyltransf_11) 		5 GLY A  39
GLY A  41
ILE A  61
ALA A  96
ASP A 101
 None
 1.12A 4a6eA-3i9fA:
11.9		 4a6eA-3i9fA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iwg ACETYLTRANSFERASE,
GNAT FAMILY

(Colwellia
psychrerythraea) 		PF00583
(Acetyltransf_1) 		5 GLY A 181
GLY A 192
ILE A 138
VAL A 224
ALA A 143
 None
None
CL  A 603 (-4.3A)
None
None
 1.17A 4a6eA-3iwgA:
undetectable		 4a6eA-3iwgA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3krs TRIOSEPHOSPHATE
ISOMERASE

(Cryptosporidium
parvum) 		PF00121
(TIM) 		5 PHE A  61
GLY A   9
GLY A   8
PHE A  11
ALA A 236
 None
 1.09A 4a6eA-3krsA:
undetectable		 4a6eA-3krsA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kv1 TRANSCRIPTIONAL
REPRESSOR

(Aliivibrio
fischeri) 		PF04198
(Sugar-bind) 		5 GLY A 188
GLY A  59
ILE A 186
VAL A 151
ALA A 119
 GOL  A 271 (-3.7A)
None
None
None
None
 1.13A 4a6eA-3kv1A:
undetectable		 4a6eA-3kv1A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lst CALO1
METHYLTRANSFERASE

(Micromonospora
echinospora) 		PF00891
(Methyltransf_2) 		5 GLY A 189
GLY A 191
VAL A 216
PHE A 238
TRP A 257
 SAH  A 346 (-4.0A)
SAH  A 346 ( 3.7A)
None
SAH  A 346 (-3.4A)
None
 0.75A 4a6eA-3lstA:
28.3		 4a6eA-3lstA:
26.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n29 CARBOXYNORSPERMIDINE
DECARBOXYLASE

(Campylobacter
jejuni) 		PF00278
(Orn_DAP_Arg_deC) 		5 LEU A  38
GLY A  42
ILE A 344
VAL A 345
ALA A 237
 None
 1.05A 4a6eA-3n29A:
undetectable		 4a6eA-3n29A:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pv2 DEGQ

(Legionella
fallonii) 		PF13180
(PDZ_2)
PF13365
(Trypsin_2) 		5 GLY A 194
GLY A  67
VAL A  23
ALA A 210
ASP A 114
 None
 1.00A 4a6eA-3pv2A:
undetectable		 4a6eA-3pv2A:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q2k OXIDOREDUCTASE

(Bordetella
pertussis) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		5 GLY A 259
GLY A 151
ILE A 254
ALA A 277
TRP A 274
 None
 1.15A 4a6eA-3q2kA:
4.6		 4a6eA-3q2kA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sg1 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE 1

(Bacillus
anthracis) 		PF00275
(EPSP_synthase) 		5 PHE A 403
GLY A 381
ILE A   4
VAL A   6
ALA A 313
 None
 1.03A 4a6eA-3sg1A:
undetectable		 4a6eA-3sg1A:
24.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sti PROTEASE DEGQ

(Escherichia
coli) 		PF13365
(Trypsin_2) 		5 GLY A 188
GLY A  65
VAL A  29
ALA A 204
ASP A 112
 None
 1.04A 4a6eA-3stiA:
undetectable		 4a6eA-3stiA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v7i PUTATIVE POLYKETIDE
SYNTHASE

(Streptomyces
coelicolor) 		PF00195
(Chal_sti_synt_N) 		5 LEU A 389
TRP A 388
GLY A 367
ALA A 370
ASP A 247
 None
 1.12A 4a6eA-3v7iA:
undetectable		 4a6eA-3v7iA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wcs ERYTHROAGGLUTININ

(Phaseolus
vulgaris) 		PF00139
(Lectin_legB) 		5 PHE A  89
GLY A 229
ILE A  76
VAL A 226
ALA A 110
 None
None
EDO  A1009 (-4.2A)
None
None
 1.14A 4a6eA-3wcsA:
undetectable		 4a6eA-3wcsA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wxr PROBABLE PROTEASOME
SUBUNIT ALPHA TYPE-7

(Saccharomyces
cerevisiae) 		PF00227
(Proteasome)
PF10584
(Proteasome_A_N) 		5 PHE G 137
LEU G  87
GLY G  91
ILE G  73
VAL G  69
 None
 1.10A 4a6eA-3wxrG:
undetectable		 4a6eA-3wxrG:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zdn MONOAMINE OXIDASE N

(Aspergillus
niger) 		PF01593
(Amino_oxidase) 		5 GLY A  47
GLY A  51
VAL A  44
PHE A 275
ALA A 258
 FAD  A1487 (-4.2A)
None
None
None
None
 1.17A 4a6eA-3zdnA:
undetectable		 4a6eA-3zdnA:
21.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4a6e HYDROXYINDOLE
O-METHYLTRANSFERASE

(Homo sapiens) 		PF00891
(Methyltransf_2)
PF16864
(Dimerisation2) 		5 LEU A 160
GLY A 188
VAL A 214
ALA A 251
ARG A 252
 SAM  A1349 (-4.1A)
SAM  A1349 ( 4.0A)
SAM  A1349 (-4.9A)
SAM  A1349 (-3.7A)
SAM  A1349 ( 3.8A)
 1.14A 4a6eA-4a6eA:
55.0		 4a6eA-4a6eA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4a6e HYDROXYINDOLE
O-METHYLTRANSFERASE

(Homo sapiens) 		PF00891
(Methyltransf_2)
PF16864
(Dimerisation2) 		12 PHE A 143
LEU A 160
TRP A 164
GLY A 187
GLY A 189
ILE A 211
VAL A 214
PHE A 237
ALA A 251
ARG A 252
ASP A 256
TRP A 257
 SAM  A1349 (-3.8A)
SAM  A1349 (-4.1A)
SAM  A1349 (-4.2A)
SAM  A1349 (-3.6A)
SAM  A1349 ( 3.8A)
SAM  A1349 (-4.6A)
SAM  A1349 (-4.9A)
SAM  A1349 (-3.5A)
SAM  A1349 (-3.7A)
SAM  A1349 ( 3.8A)
ASE  A1350 ( 2.9A)
None
 0.02A 4a6eA-4a6eA:
55.0		 4a6eA-4a6eA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4a6e HYDROXYINDOLE
O-METHYLTRANSFERASE

(Homo sapiens) 		PF00891
(Methyltransf_2)
PF16864
(Dimerisation2) 		9 PHE A 143
LEU A 160
TRP A 164
GLY A 188
ILE A 211
PHE A 237
ARG A 252
ASP A 256
TRP A 257
 SAM  A1349 (-3.8A)
SAM  A1349 (-4.1A)
SAM  A1349 (-4.2A)
SAM  A1349 ( 4.0A)
SAM  A1349 (-4.6A)
SAM  A1349 (-3.5A)
SAM  A1349 ( 3.8A)
ASE  A1350 ( 2.9A)
None
 0.94A 4a6eA-4a6eA:
55.0		 4a6eA-4a6eA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c7v TRANSKETOLASE

(Lactobacillus
salivarius) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		5 LEU A 224
GLY A 221
ILE A 244
VAL A 218
ALA A  36
 None
 1.14A 4a6eA-4c7vA:
3.5		 4a6eA-4c7vA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dzh AMIDOHYDROLASE

(Xanthomonas
campestris) 		PF01979
(Amidohydro_1) 		5 PHE A 154
GLY A  73
ILE A 414
VAL A 412
ALA A 355
 None
 1.04A 4a6eA-4dzhA:
undetectable		 4a6eA-4dzhA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4evi CONIFERYL ALCOHOL
9-O-METHYLTRANSFERAS
E

(Linum
nodiflorum) 		PF00891
(Methyltransf_2)
PF08100
(Dimerisation) 		5 GLY A 208
GLY A 210
VAL A 235
ASP A 272
TRP A 273
 SAH  A 401 (-3.6A)
SAH  A 401 ( 3.8A)
SAH  A 401 (-4.8A)
C9M  A 402 ( 2.3A)
None
 0.29A 4a6eA-4eviA:
34.0		 4a6eA-4eviA:
27.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g4i 4-O-METHYL-GLUCURONO
YL METHYLESTERASE

(Thermothelomyces
thermophila) 		no annotation 5 GLY A 211
GLY A 132
ILE A 128
ALA A 213
ARG A 214
 None
None
None
EDO  A 506 ( 4.1A)
EDO  A 506 (-3.6A)
 1.02A 4a6eA-4g4iA:
undetectable		 4a6eA-4g4iA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hds ARSA

(Sporomusa ovata) 		PF02277
(DBI_PRT) 		5 GLY A 250
GLY A 254
ILE A 160
VAL A 161
ALA A 276
 None
 1.02A 4a6eA-4hdsA:
undetectable		 4a6eA-4hdsA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hu8 GH10 XYLANASE

(Globitermes
brachycerastes) 		PF00331
(Glyco_hydro_10)
PF02368
(Big_2) 		5 GLY A 441
GLY A 387
ILE A 397
ALA A 390
ASP A 394
 None
 1.06A 4a6eA-4hu8A:
undetectable		 4a6eA-4hu8A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jot ENOYL-COA HYDRATASE,
PUTATIVE

(Deinococcus
radiodurans) 		PF00378
(ECH_1) 		5 PHE A  44
GLY A 121
PHE A  65
ALA A 126
ARG A 157
 None
 1.10A 4a6eA-4jotA:
undetectable		 4a6eA-4jotA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m3c LECTIN BETA CHAIN

(Butea
monosperma) 		PF00139
(Lectin_legB) 		5 PHE B  70
GLY B 211
ILE B  57
VAL B 208
ALA B  91
 None
None
ABU  B 303 (-3.7A)
None
None
 1.11A 4a6eA-4m3cB:
undetectable		 4a6eA-4m3cB:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mo2 UDP-GALACTOPYRANOSE
MUTASE

(Campylobacter
jejuni) 		no annotation 5 PHE B 100
LEU B 146
GLY B 139
ILE B 115
ALA B 134
 None
 1.13A 4a6eA-4mo2B:
2.4		 4a6eA-4mo2B:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ntd THIOREDOXIN
REDUCTASE

(Streptomyces
clavuligerus) 		PF07992
(Pyr_redox_2) 		5 PHE A  79
LEU A  25
GLY A  17
GLY A  20
VAL A  13
 None
None
FAD  A 402 (-3.5A)
None
None
 1.12A 4a6eA-4ntdA:
undetectable		 4a6eA-4ntdA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4otd SERINE/THREONINE-PRO
TEIN KINASE N1

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		5 GLY A 773
GLY A 771
ARG A 745
ASP A 803
TRP A 804
 None
None
TPO  A 780 ( 2.8A)
None
None
 1.09A 4a6eA-4otdA:
undetectable		 4a6eA-4otdA:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pgh CAFFEIC ACID
O-METHYLTRANSFERASE

(Sorghum bicolor) 		PF00891
(Methyltransf_2)
PF08100
(Dimerisation) 		5 GLY A 206
GLY A 208
VAL A 233
ASP A 268
TRP A 269
 SAM  A 401 (-3.8A)
SAM  A 401 ( 4.1A)
SAM  A 401 ( 4.9A)
None
None
 0.63A 4a6eA-4pghA:
30.7		 4a6eA-4pghA:
26.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rep GAMMA-CAROTENE
DESATURASE

(Nonlabens
dokdonensis) 		PF01593
(Amino_oxidase) 		5 PHE A 241
LEU A  18
GLY A  10
GLY A  13
VAL A   6
 None
None
FAD  A 501 (-3.4A)
None
None
 0.96A 4a6eA-4repA:
3.2		 4a6eA-4repA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rnc ESTERASE

(Rhodococcus sp.
ECU1013) 		PF12697
(Abhydrolase_6) 		5 GLY A  80
ILE A  14
VAL A  85
ALA A 113
TRP A  78
 None
 1.09A 4a6eA-4rncA:
undetectable		 4a6eA-4rncA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s3k SPORE GERMINATION
PROTEIN YAAH

(Bacillus
megaterium) 		PF00704
(Glyco_hydro_18)
PF01476
(LysM) 		5 TRP A 407
GLY A 136
GLY A 108
PHE A 167
ALA A 138
 None
 1.07A 4a6eA-4s3kA:
undetectable		 4a6eA-4s3kA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u36 SEED LECTIN

(Vatairea
macrocarpa) 		PF00139
(Lectin_legB) 		5 PHE A  69
GLY A 206
ILE A  56
VAL A 203
ALA A  90
 None
 1.10A 4a6eA-4u36A:
undetectable		 4a6eA-4u36A:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ykn PHOSPHATIDYLINOSITOL
3-KINASE REGULATORY
SUBUNIT
ALPHA,PHOSPHATIDYLIN
OSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT ALPHA
ISOFORM FUSION
PROTEIN

(Homo sapiens) 		PF00017
(SH2)
PF00454
(PI3_PI4_kinase)
PF00613
(PI3Ka)
PF00792
(PI3K_C2)
PF00794
(PI3K_rbd)
PF02192
(PI3K_p85B)
PF16454
(PI3K_P85_iSH2) 		5 PHE A2016
LEU A1570
TRP A1574
GLY A1364
ASP A1603
 None
 1.01A 4a6eA-4yknA:
undetectable		 4a6eA-4yknA:
13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ysh GLYCINE OXIDASE

(Geobacillus
kaustophilus) 		PF01266
(DAO) 		5 LEU A 367
GLY A 216
ILE A 183
VAL A 219
ALA A 332
 None
 1.04A 4a6eA-4yshA:
2.3		 4a6eA-4yshA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5awp ISOMALTODEXTRANASE

(Arthrobacter
globiformis) 		no annotation 5 LEU A 584
GLY A 303
GLY A 305
ILE A 308
ALA A 477
 None
 1.14A 4a6eA-5awpA:
undetectable		 4a6eA-5awpA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cvv (ISO)EUGENOL
O-METHYLTRANSFERASE

(Clarkia breweri) 		PF00891
(Methyltransf_2)
PF08100
(Dimerisation) 		5 GLY A 211
GLY A 213
VAL A 238
ASP A 273
TRP A 274
 SAH  A 401 (-3.8A)
SAH  A 401 ( 3.7A)
None
N7I  A 402 ( 2.7A)
None
 0.39A 4a6eA-5cvvA:
35.2		 4a6eA-5cvvA:
25.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5elp NRPS/PKS PROTEIN

(Bacillus
amyloliquefaciens) 		no annotation 5 LEU C 185
ILE C  17
VAL C 251
PHE C  30
ALA C 362
 None
 1.12A 4a6eA-5elpC:
undetectable		 4a6eA-5elpC:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h5l GLUTATHIONE
S-TRANSFERASE S2

(Nilaparvata
lugens) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		5 PHE A  29
GLY A  15
ALA A  12
ARG A 197
ASP A  31
 None
 1.14A 4a6eA-5h5lA:
undetectable		 4a6eA-5h5lA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hj7 GLUTAMATE RACEMASE

(Mycobacterium
tuberculosis) 		PF01177
(Asp_Glu_race) 		5 PHE A 148
LEU A 181
GLY A 118
GLY A 184
ALA A 142
 None
 1.10A 4a6eA-5hj7A:
undetectable		 4a6eA-5hj7A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i2h O-METHYLTRANSFERASE
FAMILY 2

(Planctopirus
limnophila) 		PF00891
(Methyltransf_2)
PF16864
(Dimerisation2) 		5 LEU A 162
GLY A 202
VAL A 228
ASP A 271
TRP A 272
 None
None
None
AGI  A 501 (-2.4A)
None
 0.81A 4a6eA-5i2hA:
22.0		 4a6eA-5i2hA:
27.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i2h O-METHYLTRANSFERASE
FAMILY 2

(Planctopirus
limnophila) 		PF00891
(Methyltransf_2)
PF16864
(Dimerisation2) 		5 LEU A 162
GLY A 203
VAL A 228
ASP A 271
TRP A 272
 None
None
None
AGI  A 501 (-2.4A)
None
 0.71A 4a6eA-5i2hA:
22.0		 4a6eA-5i2hA:
27.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i70 PLASMEPSIN IV

(Plasmodium
falciparum) 		no annotation 5 LEU B 191
GLY B  36
ILE B 300
VAL B 212
ALA B  38
 None
 0.90A 4a6eA-5i70B:
undetectable		 4a6eA-5i70B:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5icl LIPOATE--PROTEIN
LIGASE

(Enterococcus
faecalis) 		PF03099
(BPL_LplA_LipB)
PF10437
(Lip_prot_lig_C) 		5 PHE A  84
LEU A 125
ILE A 209
PHE A  -2
ALA A  99
 None
 1.08A 4a6eA-5iclA:
undetectable		 4a6eA-5iclA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jfc NADH-DEPENDENT
FERREDOXIN:NADP
OXIDOREDUCTASE
SUBUNIT ALPHA

(Pyrococcus
furiosus) 		PF07992
(Pyr_redox_2)
PF14691
(Fer4_20) 		5 GLY L 246
GLY L 248
ILE L 446
PHE L 244
ALA L 162
 None
FAD  L 503 (-3.1A)
None
None
None
 0.92A 4a6eA-5jfcL:
3.2		 4a6eA-5jfcL:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jia RAN-BINDING PROTEIN
10

(Mus musculus) 		PF00622
(SPRY) 		5 LEU A 132
GLY A 121
GLY A 141
ILE A 169
PHE A 105
 None
 1.12A 4a6eA-5jiaA:
undetectable		 4a6eA-5jiaA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jiu RAN-BINDING PROTEIN
9

(Homo sapiens) 		PF00622
(SPRY) 		5 LEU A 244
GLY A 233
GLY A 253
ILE A 281
PHE A 217
 None
 1.13A 4a6eA-5jiuA:
undetectable		 4a6eA-5jiuA:
24.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jlt MIDDLE TRANSCRIPTION
REGULATORY PROTEIN
MOTA

(Escherichia
virus T4) 		PF09158
(MotCF) 		5 PHE A 175
GLY A 148
GLY A 164
ILE A 172
VAL A 190
 None
 1.14A 4a6eA-5jltA:
undetectable		 4a6eA-5jltA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jr3 CARMINOMYCIN
4-O-METHYLTRANSFERAS
E DNRK

(Streptomyces
peucetius) 		PF00891
(Methyltransf_2) 		5 LEU A 160
GLY A 187
GLY A 189
PHE A 238
TRP A 258
 SAH  A 401 (-4.1A)
SAH  A 401 (-3.9A)
SAH  A 401 ( 3.8A)
SAH  A 401 (-3.4A)
None
 0.66A 4a6eA-5jr3A:
32.2		 4a6eA-5jr3A:
29.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kva CAFFEOYL-COA
O-METHYLTRANSFERASE

(Sorghum bicolor) 		PF01596
(Methyltransf_3) 		5 PHE A 149
GLY A 105
GLY A 134
ILE A 147
ASP A 125
 None
SAM  A 301 ( 4.8A)
None
None
SAM  A 301 (-2.8A)
 1.00A 4a6eA-5kvaA:
11.3		 4a6eA-5kvaA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kxb WISTERIA FLORIBUNDA
AGGLUTININ

(Wisteria
floribunda) 		PF00139
(Lectin_legB) 		5 PHE A  99
GLY A 238
ILE A  86
VAL A 235
ALA A 120
 None
 1.11A 4a6eA-5kxbA:
undetectable		 4a6eA-5kxbA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l10 N-ACYLHOMOSERINE
LACTONE DEPENDENT
REGULATORY PROTEIN

(Burkholderia
cenocepacia) 		PF03472
(Autoind_bind) 		5 GLY A 127
GLY A 118
ILE A  79
VAL A  82
ALA A 157
 None
 1.17A 4a6eA-5l10A:
undetectable		 4a6eA-5l10A:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lf7 PROTEASOME SUBUNIT
BETA TYPE-1

(Homo sapiens) 		PF00227
(Proteasome) 		5 LEU L  46
GLY L 111
ILE L  12
VAL L  23
ALA L  89
 None
 1.05A 4a6eA-5lf7L:
undetectable		 4a6eA-5lf7L:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vj4 UNCHARACTERIZED
PROTEIN

(Borrelia
turicatae) 		no annotation 5 LEU A 230
GLY A 234
ILE A 240
PHE A 294
ALA A 288
 None
 1.11A 4a6eA-5vj4A:
undetectable		 4a6eA-5vj4A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vj7 OXIDOREDUCTASE

(Pyrococcus
furiosus) 		PF07992
(Pyr_redox_2)
PF14691
(Fer4_20) 		5 GLY A 246
GLY A 248
ILE A 447
PHE A 244
ALA A 162
 None
FAD  A 503 (-3.1A)
None
None
FAD  A 503 (-4.8A)
 0.94A 4a6eA-5vj7A:
2.8		 4a6eA-5vj7A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vyl INNER TEGUMENT
PROTEIN

(Human
alphaherpesvirus
1) 		PF03970
(Herpes_UL37_1) 		5 LEU A 224
GLY A 112
ILE A 140
VAL A 115
ALA A 161
 None
 1.04A 4a6eA-5vylA:
undetectable		 4a6eA-5vylA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w16 GLUTAMATE RACEMASE

(Thermus
thermophilus) 		no annotation 5 PHE A 140
LEU A 172
GLY A 115
GLY A 175
ALA A 134
 None
 1.09A 4a6eA-5w16A:
undetectable		 4a6eA-5w16A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w7p OXAC

(Penicillium
oxalicum) 		no annotation 6 PHE A 194
GLY A 244
PHE A 293
ARG A 310
ASP A 314
TRP A 315
 SAM  A 501 (-3.7A)
SAM  A 501 ( 3.8A)
SAM  A 501 (-3.3A)
SAM  A 501 (-4.1A)
SAM  A 501 ( 4.2A)
None
 1.13A 4a6eA-5w7pA:
29.0		 4a6eA-5w7pA:
25.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w7p OXAC

(Penicillium
oxalicum) 		no annotation 6 PHE A 194
VAL A 273
PHE A 293
ARG A 310
ASP A 314
TRP A 315
 SAM  A 501 (-3.7A)
SAM  A 501 (-4.8A)
SAM  A 501 (-3.3A)
SAM  A 501 (-4.1A)
SAM  A 501 ( 4.2A)
None
 0.61A 4a6eA-5w7pA:
29.0		 4a6eA-5w7pA:
25.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wjc KINETOCHORE PROTEIN
MIS16

(Schizosaccharomyces
pombe) 		no annotation 6 TRP A 210
GLY A 185
GLY A 201
ILE A 237
VAL A 238
ALA A 156
 None
 1.35A 4a6eA-5wjcA:
undetectable		 4a6eA-5wjcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x1n VANILLATE/3-O-METHYL
GALLATE
O-DEMETHYLASE

(Sphingobium sp.
SYK-6) 		PF01571
(GCV_T)
PF08669
(GCV_T_C) 		5 GLY A 101
ILE A  80
VAL A  97
PHE A 315
ALA A 327
 None
 1.08A 4a6eA-5x1nA:
undetectable		 4a6eA-5x1nA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x8o INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Trypanosoma
brucei) 		no annotation 5 LEU A 230
GLY A  73
ILE A 349
VAL A  50
ALA A 253
 None
 1.12A 4a6eA-5x8oA:
undetectable		 4a6eA-5x8oA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xgj PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT ALPHA
ISOFORM

(Homo sapiens) 		no annotation 5 PHE A1016
LEU A 570
TRP A 574
GLY A 364
ASP A 603
 None
 1.01A 4a6eA-5xgjA:
undetectable		 4a6eA-5xgjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xoh BERGAPTOL
O-METHYLTRANSFERASE

(Peucedanum
praeruptorum) 		no annotation 5 PHE A 158
GLY A 203
GLY A 205
VAL A 230
TRP A 266
 SAH  A 401 ( 3.6A)
SAH  A 401 (-3.4A)
SAH  A 401 ( 3.7A)
None
None
 0.55A 4a6eA-5xohA:
33.3		 4a6eA-5xohA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yal ESTERASE

(Streptomyces
cinnamoneus) 		no annotation 5 GLY A 267
GLY A 294
PHE A 271
ALA A 265
ASP A 262
 None
 0.93A 4a6eA-5yalA:
undetectable		 4a6eA-5yalA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yo8 TETRAPRENYL-BETA-CUR
CUMENE SYNTHASE

(Bacillus
alcalophilus) 		no annotation 5 LEU A  64
GLY A  58
GLY A  60
VAL A  22
PHE A  54
 None
 1.02A 4a6eA-5yo8A:
undetectable		 4a6eA-5yo8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c5b METHYLTRANSFERASE

(Lysobacter
antibioticus) 		no annotation 7 PHE A 138
GLY A 182
GLY A 184
VAL A 209
PHE A 233
ASP A 252
TRP A 253
 SAH  A 501 ( 3.9A)
SAH  A 501 (-4.0A)
SAH  A 501 (-3.3A)
SAH  A 501 ( 4.9A)
SAH  A 501 (-3.5A)
SAH  A 501 (-4.0A)
None
 0.58A 4a6eA-6c5bA:
35.8		 4a6eA-6c5bA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cmz DIHYDROLIPOYL
DEHYDROGENASE

(Burkholderia
cenocepacia) 		no annotation 5 LEU A 266
GLY A 191
ILE A  55
VAL A 193
ALA A 183
 None
 1.12A 4a6eA-6cmzA:
2.8		 4a6eA-6cmzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fn1 HUMAN-MOUSE CHIMERIC
ABCB1 (ABCBHM)

(Homo sapiens) 		no annotation 5 PHE A 696
GLY A 829
GLY A 826
ILE A 699
ALA A 833
 None
 1.12A 4a6eA-6fn1A:
undetectable		 4a6eA-6fn1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cbg CYANOGENIC
BETA-GLUCOSIDASE

(Trifolium
repens) 		PF00232
(Glyco_hydro_1) 		3 TYR A 383
ASP A 276
ASP A 269
 None
 0.49A 4a6eA-1cbgA:
undetectable		 4a6eA-1cbgA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cli PROTEIN
(PHOSPHORIBOSYL-AMIN
OIMIDAZOLE
SYNTHETASE)

(Escherichia
coli) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		3 TYR A 194
ASP A  86
ASP A  65
 None
 0.88A 4a6eA-1cliA:
undetectable		 4a6eA-1cliA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p4t OUTER MEMBRANE
PROTEIN NSPA

(Neisseria
meningitidis) 		PF02462
(Opacity) 		3 TYR A  62
ASP A  99
ASP A  58
 None
 0.88A 4a6eA-1p4tA:
undetectable		 4a6eA-1p4tA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli) 		PF00724
(Oxidored_FMN)
PF07992
(Pyr_redox_2) 		3 TYR A   2
ASP A 291
ASP A 316
 None
 0.88A 4a6eA-1ps9A:
2.8		 4a6eA-1ps9A:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qgu PROTEIN (NITROGENASE
MOLYBDENUM IRON
PROTEIN)

(Klebsiella
pneumoniae) 		PF00148
(Oxidored_nitro) 		3 TYR A 352
ASP A 400
ASP A 384
 None
 0.70A 4a6eA-1qguA:
undetectable		 4a6eA-1qguA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qq0 CARBONIC ANHYDRASE

(Methanosarcina
thermophila) 		PF00132
(Hexapep)
PF14602
(Hexapep_2) 		3 TYR A 108
ASP A 129
ASP A 163
 None
 0.79A 4a6eA-1qq0A:
undetectable		 4a6eA-1qq0A:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r62 NITROGEN REGULATION
PROTEIN NR(II)

(Escherichia
coli) 		PF02518
(HATPase_c) 		3 TYR A 344
ASP A 284
ASP A 225
 None
 0.62A 4a6eA-1r62A:
undetectable		 4a6eA-1r62A:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uan HYPOTHETICAL PROTEIN
TT1542

(Thermus
thermophilus) 		PF02585
(PIG-L) 		3 TYR A 173
ASP A  36
ASP A  74
 None
 0.88A 4a6eA-1uanA:
2.6		 4a6eA-1uanA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vkd CONSERVED
HYPOTHETICAL PROTEIN
TM1225

(Thermotoga
maritima) 		PF04041
(Glyco_hydro_130) 		3 TYR A 117
ASP A 114
ASP A 136
 None
 0.74A 4a6eA-1vkdA:
undetectable		 4a6eA-1vkdA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wj5 HYPOTHETICAL PROTEIN
(RIKEN CDNA
0610009H20)

(Mus musculus) 		PF09170
(STN1_2) 		3 TYR A 105
ASP A  97
ASP A 101
 None
 0.80A 4a6eA-1wj5A:
3.3		 4a6eA-1wj5A:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xmb IAA-AMINO ACID
HYDROLASE HOMOLOG 2

(Arabidopsis
thaliana) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		3 TYR A 401
ASP A 140
ASP A 114
 None
 0.88A 4a6eA-1xmbA:
undetectable		 4a6eA-1xmbA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xmx HYPOTHETICAL PROTEIN
VC1899

(Vibrio cholerae) 		PF09002
(DUF1887) 		3 TYR A 145
ASP A  11
ASP A 328
 None
 0.58A 4a6eA-1xmxA:
2.8		 4a6eA-1xmxA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yby TRANSLATION
ELONGATION FACTOR P

(Ruminiclostridium
thermocellum) 		PF01132
(EFP)
PF08207
(EFP_N)
PF09285
(Elong-fact-P_C) 		3 TYR A  81
ASP A  78
ASP A  96
 None
 0.84A 4a6eA-1ybyA:
undetectable		 4a6eA-1ybyA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ar1 HYPOTHETICAL PROTEIN

(Leishmania
major) 		PF01878
(EVE) 		3 TYR A  42
ASP A  94
ASP A  81
 None
 0.81A 4a6eA-2ar1A:
undetectable		 4a6eA-2ar1A:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b67 COG0778:
NITROREDUCTASE

(Streptococcus
pneumoniae) 		PF00881
(Nitroreductase) 		3 TYR A 181
ASP A  25
ASP A 145
 None
 0.72A 4a6eA-2b67A:
undetectable		 4a6eA-2b67A:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bra NEDD9 INTERACTING
PROTEIN WITH
CALPONIN HOMOLOGY
AND LIM DOMAINS

(Mus musculus) 		PF01494
(FAD_binding_3) 		3 TYR A 144
ASP A 289
ASP A 153
 None
 0.83A 4a6eA-2braA:
undetectable		 4a6eA-2braA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cug MKIAA0962 PROTEIN

(Mus musculus) 		PF00226
(DnaJ) 		3 TYR A  78
ASP A  18
ASP A  16
 None
 0.85A 4a6eA-2cugA:
undetectable		 4a6eA-2cugA:
14.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2edz PDZ
DOMAIN-CONTAINING
PROTEIN 1

(Mus musculus) 		PF00595
(PDZ) 		3 TYR A  99
ASP A  71
ASP A 108
 None
 0.59A 4a6eA-2edzA:
undetectable		 4a6eA-2edzA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hcz BETA-EXPANSIN 1A

(Zea mays) 		PF01357
(Pollen_allerg_1)
PF03330
(DPBB_1) 		3 TYR X  74
ASP X 173
ASP X 170
 None
 0.73A 4a6eA-2hczX:
undetectable		 4a6eA-2hczX:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jf7 STRICTOSIDINE-O-BETA
-D-GLUCOSIDASE

(Rauvolfia
serpentina) 		PF00232
(Glyco_hydro_1) 		3 TYR A 402
ASP A 295
ASP A 288
 None
 0.60A 4a6eA-2jf7A:
undetectable		 4a6eA-2jf7A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l8a ENDOGLUCANASE

(Bacillus
subtilis) 		PF00942
(CBM_3) 		3 TYR A 393
ASP A 469
ASP A 431
 None
 0.83A 4a6eA-2l8aA:
undetectable		 4a6eA-2l8aA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nef NEGATIVE FACTOR
(F-PROTEIN)

(Human
immunodeficiency
virus 1) 		PF00469
(F-protein) 		3 TYR A 127
ASP A 111
ASP A 123
 None
 0.73A 4a6eA-2nefA:
undetectable		 4a6eA-2nefA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oaj PROTEIN SNI1

(Saccharomyces
cerevisiae) 		PF08596
(Lgl_C) 		3 TYR A 131
ASP A 171
ASP A 167
 None
 0.88A 4a6eA-2oajA:
undetectable		 4a6eA-2oajA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p91 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH]

(Aquifex
aeolicus) 		PF13561
(adh_short_C2) 		3 TYR A 136
ASP A  83
ASP A  79
 None
 0.87A 4a6eA-2p91A:
5.2		 4a6eA-2p91A:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pge MENC

(Desulfotalea
psychrophila) 		PF13378
(MR_MLE_C) 		3 TYR A 300
ASP A 108
ASP A 102
 None
 0.81A 4a6eA-2pgeA:
undetectable		 4a6eA-2pgeA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2psy KALLIKREIN-5

(Homo sapiens) 		PF00089
(Trypsin) 		3 TYR A 228
ASP A 189
ASP A 185
 None
 0.88A 4a6eA-2psyA:
undetectable		 4a6eA-2psyA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qvp UNCHARACTERIZED
PROTEIN

(Shewanella
amazonensis) 		PF04952
(AstE_AspA) 		3 TYR A 177
ASP A 211
ASP A 225
 None
 0.88A 4a6eA-2qvpA:
undetectable		 4a6eA-2qvpA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r26 CITRATE SYNTHASE

(Thermoplasma
acidophilum) 		PF00285
(Citrate_synt) 		3 TYR A  56
ASP A 122
ASP A 118
 None
 0.74A 4a6eA-2r26A:
undetectable		 4a6eA-2r26A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yw9 ENOYL-[ACYL CARRIER
PROTEIN] REDUCTASE

(Thermus
thermophilus) 		PF13561
(adh_short_C2) 		3 TYR A 123
ASP A  70
ASP A  66
 None
 0.80A 4a6eA-2yw9A:
5.5		 4a6eA-2yw9A:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bvm ENTEROTOXIN TYPE C-3

(Staphylococcus
aureus) 		PF01123
(Stap_Strp_toxin)
PF02876
(Stap_Strp_tox_C) 		3 TYR A  90
ASP A  55
ASP A  62
 None
 0.86A 4a6eA-3bvmA:
undetectable		 4a6eA-3bvmA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cf4 ACETYL-COA
DECARBOXYLASE/SYNTHA
SE ALPHA SUBUNIT

(Methanosarcina
barkeri) 		PF03063
(Prismane) 		3 TYR A 378
ASP A 320
ASP A 282
 None
 0.85A 4a6eA-3cf4A:
2.6		 4a6eA-3cf4A:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cgd PYRIDINE
NUCLEOTIDE-DISULFIDE
OXIDOREDUCTASE,
CLASS I

(Bacillus
anthracis) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		3 TYR A 278
ASP A 316
ASP A  23
 None
 0.72A 4a6eA-3cgdA:
3.7		 4a6eA-3cgdA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d46 PUTATIVE GALACTONATE
DEHYDRATASE

(Salmonella
enterica) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 TYR A 235
ASP A 206
ASP A 226
 None
None
MG  A 501 ( 2.5A)
 0.78A 4a6eA-3d46A:
undetectable		 4a6eA-3d46A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ek2 ENOYL-(ACYL-CARRIER-
PROTEIN) REDUCTASE
(NADH)

(Burkholderia
pseudomallei) 		PF13561
(adh_short_C2) 		3 TYR A 122
ASP A  68
ASP A  64
 None
 0.86A 4a6eA-3ek2A:
5.1		 4a6eA-3ek2A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ezy DEHYDROGENASE

(Thermotoga
maritima) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		3 TYR A 279
ASP A 152
ASP A 236
 None
 0.70A 4a6eA-3ezyA:
3.8		 4a6eA-3ezyA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hsk ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE

(Candida
albicans) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		3 TYR A 111
ASP A  92
ASP A  88
 None
 0.85A 4a6eA-3hskA:
undetectable		 4a6eA-3hskA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica) 		PF03063
(Prismane) 		3 TYR A 242
ASP A 558
ASP A 552
 None
 0.75A 4a6eA-3i04A:
undetectable		 4a6eA-3i04A:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iuu PUTATIVE
METALLOPEPTIDASE

(Chelativorans
sp. BNC1) 		PF07171
(MlrC_C)
PF07364
(DUF1485) 		3 TYR A 332
ASP A  27
ASP A 391
 None
 0.68A 4a6eA-3iuuA:
2.9		 4a6eA-3iuuA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iz3 VIRAL STRUCTURAL
PROTEIN 5

(Cypovirus 1) 		no annotation 3 TYR D 112
ASP D 108
ASP D  70
 None
 0.78A 4a6eA-3iz3D:
undetectable		 4a6eA-3iz3D:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kzw CYTOSOL
AMINOPEPTIDASE

(Staphylococcus
aureus) 		PF00883
(Peptidase_M17)
PF02789
(Peptidase_M17_N) 		3 TYR A 354
ASP A 211
ASP A 214
 None
 0.79A 4a6eA-3kzwA:
undetectable		 4a6eA-3kzwA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nbm PTS SYSTEM,
LACTOSE-SPECIFIC
IIBC COMPONENTS

(Streptococcus
pneumoniae) 		PF02302
(PTS_IIB) 		3 TYR A 493
ASP A 522
ASP A 498
 None
 0.79A 4a6eA-3nbmA:
undetectable		 4a6eA-3nbmA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nva CTP SYNTHASE

(Sulfolobus
solfataricus) 		PF00117
(GATase)
PF06418
(CTP_synth_N) 		3 TYR A  76
ASP A  70
ASP A 307
 None
 0.84A 4a6eA-3nvaA:
undetectable		 4a6eA-3nvaA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o8o 6-PHOSPHOFRUCTOKINAS
E SUBUNIT ALPHA
6-PHOSPHOFRUCTOKINAS
E SUBUNIT BETA

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		PF00365
(PFK)
PF00365
(PFK) 		3 TYR A 381
ASP B 365
ASP B 372
 None
 0.88A 4a6eA-3o8oA:
undetectable		 4a6eA-3o8oA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3otm CARBONIC ANHYDRASE

(Methanosarcina
thermophila) 		PF00132
(Hexapep)
PF14602
(Hexapep_2) 		3 TYR A 108
ASP A 129
ASP A 163
 None
 0.81A 4a6eA-3otmA:
undetectable		 4a6eA-3otmA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pei CYTOSOL
AMINOPEPTIDASE

(Francisella
tularensis) 		PF00883
(Peptidase_M17)
PF02789
(Peptidase_M17_N) 		3 TYR A 345
ASP A 202
ASP A 205
 None
 0.86A 4a6eA-3peiA:
undetectable		 4a6eA-3peiA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ptk BETA-GLUCOSIDASE
OS4BGLU12

(Oryza sativa) 		PF00232
(Glyco_hydro_1) 		3 TYR A 379
ASP A 272
ASP A 265
 None
 0.49A 4a6eA-3ptkA:
undetectable		 4a6eA-3ptkA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sqi KLLA0E03807P

(Kluyveromyces
lactis) 		PF16787
(NDC10_II) 		3 TYR A  53
ASP A  59
ASP A  63
 None
 0.86A 4a6eA-3sqiA:
undetectable		 4a6eA-3sqiA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t79 KLLA0E03807P

(Kluyveromyces
lactis) 		PF16787
(NDC10_II) 		3 TYR A  53
ASP A  59
ASP A  63
 None
 0.87A 4a6eA-3t79A:
undetectable		 4a6eA-3t79A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t8l ADENINE DEAMINASE 2

(Agrobacterium
fabrum) 		PF01979
(Amidohydro_1)
PF13382
(Adenine_deam_C) 		3 TYR A 105
ASP A  90
ASP A 120
 None
 0.87A 4a6eA-3t8lA:
undetectable		 4a6eA-3t8lA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v9f TWO-COMPONENT SYSTEM
SENSOR HISTIDINE
KINASE/RESPONSE
REGULATOR, HYBRID
(ONE-COMPONENT
SYSTEM)

(Bacteroides
thetaiotaomicron) 		PF07494
(Reg_prop)
PF07495
(Y_Y_Y) 		3 TYR A 448
ASP A 432
ASP A 388
 None
 0.79A 4a6eA-3v9fA:
undetectable		 4a6eA-3v9fA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vbo GENOME POLYPROTEIN,
CAPSID PROTEIN VP2

(Enterovirus A) 		PF00073
(Rhv) 		3 TYR B 217
ASP B 153
ASP B 225
 None
 0.78A 4a6eA-3vboB:
undetectable		 4a6eA-3vboB:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vuu ERYTHROCYTE MEMBRANE
PROTEIN, PUTATIVE

(Plasmodium
falciparum) 		PF05424
(Duffy_binding) 		3 TYR A 237
ASP A 219
ASP A 229
 None
 0.63A 4a6eA-3vuuA:
undetectable		 4a6eA-3vuuA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vuv ERYTHROCYTE MEMBRANE
PROTEIN, PUTATIVE

(Plasmodium
falciparum) 		PF05424
(Duffy_binding) 		3 TYR A 237
ASP A 219
ASP A 229
 None
 0.68A 4a6eA-3vuvA:
undetectable		 4a6eA-3vuvA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wq4 BETA-PRIMEVEROSIDASE

(Camellia
sinensis) 		PF00232
(Glyco_hydro_1) 		3 TYR A 402
ASP A 295
ASP A 288
 None
 0.77A 4a6eA-3wq4A:
undetectable		 4a6eA-3wq4A:
21.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4a6e HYDROXYINDOLE
O-METHYLTRANSFERASE

(Homo sapiens) 		PF00891
(Methyltransf_2)
PF16864
(Dimerisation2) 		3 TYR A 147
ASP A 210
ASP A 236
 SAM  A1349 (-4.7A)
SAM  A1349 (-2.9A)
SAM  A1349 (-3.5A)
 0.01A 4a6eA-4a6eA:
55.0		 4a6eA-4a6eA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b28 METALLOPEPTIDASE,
FAMILY M24, PUTATIVE

(Roseobacter
denitrificans) 		PF00557
(Peptidase_M24) 		3 TYR A 366
ASP A 307
ASP A 422
 None
FE  A1446 ( 2.2A)
None
 0.77A 4a6eA-4b28A:
undetectable		 4a6eA-4b28A:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b9g CS6 FIMBRIAL SUBUNIT
B, CS6 FIMBRIAL
SUBUNIT A

(Escherichia
coli) 		PF16831
(CssAB) 		3 TYR A 130
ASP A  31
ASP A  29
 None
 0.74A 4a6eA-4b9gA:
undetectable		 4a6eA-4b9gA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c1s GLYCOSIDE HYDROLASE
FAMILY 76
MANNOSIDASE

(Bacteroides
thetaiotaomicron) 		PF03663
(Glyco_hydro_76) 		3 TYR A 407
ASP A 348
ASP A 341
 None
 0.79A 4a6eA-4c1sA:
undetectable		 4a6eA-4c1sA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d8m PESTICIDAL CRYSTAL
PROTEIN CRY5BA

(Bacillus
thuringiensis) 		PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N) 		3 TYR A 264
ASP A 198
ASP A 191
 None
 0.79A 4a6eA-4d8mA:
undetectable		 4a6eA-4d8mA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4da5 CHOLINE KINASE ALPHA

(Homo sapiens) 		PF01633
(Choline_kinase) 		3 TYR A 280
ASP A 446
ASP A 439
 None
 0.82A 4a6eA-4da5A:
undetectable		 4a6eA-4da5A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eca L-ASPARAGINE
AMIDOHYDROLASE

(Escherichia
coli) 		PF00710
(Asparaginase) 		3 TYR A  25
ASP A  90
ASP A  60
 AEI  A  12 (-4.0A)
AEI  A  12 (-2.7A)
None
 0.88A 4a6eA-4ecaA:
undetectable		 4a6eA-4ecaA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4epu ANGIOPOIETIN-1

(Homo sapiens) 		PF00147
(Fibrinogen_C) 		3 TYR A 404
ASP A 424
ASP A 450
 None
 0.69A 4a6eA-4epuA:
undetectable		 4a6eA-4epuA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hoo LYSINE-SPECIFIC
DEMETHYLASE 4D

(Homo sapiens) 		PF02373
(JmjC)
PF02375
(JmjN) 		3 TYR A 279
ASP A 197
ASP A 195
 None
 0.84A 4a6eA-4hooA:
undetectable		 4a6eA-4hooA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mrm GAMMA-AMINOBUTYRIC
ACID TYPE B RECEPTOR
SUBUNIT 2

(Homo sapiens) 		PF01094
(ANF_receptor) 		3 TYR B 277
ASP B 247
ASP B 228
 None
 0.85A 4a6eA-4mrmB:
undetectable		 4a6eA-4mrmB:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nh0 CELL
DIVISIONFTSK/SPOIIIE

(Thermomonospora
curvata) 		PF01580
(FtsK_SpoIIIE) 		3 TYR A 928
ASP A 931
ASP A 935
 None
 0.77A 4a6eA-4nh0A:
undetectable		 4a6eA-4nh0A:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nov XYLOSIDASE/ARABINOFU
RANOSIDASE XSA43E

(Butyrivibrio
proteoclasticus) 		PF04616
(Glyco_hydro_43) 		3 TYR A  35
ASP A  32
ASP A  62
 None
 0.44A 4a6eA-4novA:
undetectable		 4a6eA-4novA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o2w E3 UBIQUITIN-PROTEIN
LIGASE HERC1

(Homo sapiens) 		PF00415
(RCC1) 		3 TYR A4111
ASP A4108
ASP A4120
 None
 0.87A 4a6eA-4o2wA:
undetectable		 4a6eA-4o2wA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ofs PROBABLE LIPOAMIDE
ACYLTRANSFERASE

(Thermoplasma
acidophilum) 		PF00198
(2-oxoacid_dh) 		3 TYR A  88
ASP A 194
ASP A 199
 None
 0.84A 4a6eA-4ofsA:
undetectable		 4a6eA-4ofsA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ox3 PUTATIVE
CARBOXYPEPTIDASE
YODJ

(Bacillus
subtilis) 		PF02557
(VanY) 		3 TYR A 179
ASP A 162
ASP A 155
 None
 0.71A 4a6eA-4ox3A:
undetectable		 4a6eA-4ox3A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4psw HISTONE
ACETYLTRANSFERASE
TYPE B CATALYTIC
SUBUNIT

(Saccharomyces
cerevisiae) 		PF00583
(Acetyltransf_1)
PF10394
(Hat1_N) 		3 TYR A  49
ASP A  82
ASP A  78
 None
 0.84A 4a6eA-4pswA:
2.0		 4a6eA-4pswA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qtb MITOGEN-ACTIVATED
PROTEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		3 TYR A 333
ASP A 141
ASP A 300
 None
EDO  A 407 (-4.3A)
None
 0.84A 4a6eA-4qtbA:
undetectable		 4a6eA-4qtbA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ru0 PUTATIVE
BRANCHED-CHAIN AMINO
ACID ABC
TRANSPORTER,
PERIPLASMIC
BRANCHED-CHAIN AMINO
ACID-BINDING PROTEIN

(Pseudomonas
protegens) 		PF13458
(Peripla_BP_6) 		3 TYR A 323
ASP A 272
ASP A 264
 None
 0.74A 4a6eA-4ru0A:
undetectable		 4a6eA-4ru0A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rzz PEPTIDASE M24

(Ruegeria
lacuscaerulensis) 		PF00557
(Peptidase_M24) 		3 TYR A 366
ASP A 307
ASP A 422
 PO4  A 503 (-4.5A)
FE  A 502 (-2.3A)
None
 0.74A 4a6eA-4rzzA:
undetectable		 4a6eA-4rzzA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tqg PUTATIVE
DTDP-D-GLUCOSE 4
6-DEHYDRATASE

(Megavirus
chiliensis) 		PF02719
(Polysacc_synt_2) 		3 TYR A 316
ASP A 210
ASP A 281
 None
 0.88A 4a6eA-4tqgA:
5.0		 4a6eA-4tqgA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4up7 LYSINE--TRNA LIGASE

(Entamoeba
histolytica) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon) 		3 TYR A 231
ASP A 516
ASP A 521
 None
 0.77A 4a6eA-4up7A:
undetectable		 4a6eA-4up7A:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v20 CELLOBIOHYDROLASE

(Aspergillus
fumigatus) 		PF00840
(Glyco_hydro_7) 		3 TYR A 247
ASP A 173
ASP A 257
 None
 0.80A 4a6eA-4v20A:
undetectable		 4a6eA-4v20A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wn9 NITROGENASE
MOLYBDENUM-IRON
PROTEIN ALPHA CHAIN

(Clostridium
pasteurianum) 		PF00148
(Oxidored_nitro) 		3 TYR A 342
ASP A 442
ASP A 374
 None
 0.70A 4a6eA-4wn9A:
undetectable		 4a6eA-4wn9A:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wu0 SIMILAR TO YTER
(BACILUS SUBTILIS)

(Clostridium
acetobutylicum) 		PF07470
(Glyco_hydro_88) 		3 TYR A  95
ASP A  55
ASP A  48
 None
 0.83A 4a6eA-4wu0A:
undetectable		 4a6eA-4wu0A:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wzb NITROGENASE
MOLYBDENUM-IRON
PROTEIN ALPHA CHAIN

(Azotobacter
vinelandii) 		PF00148
(Oxidored_nitro) 		3 TYR A 354
ASP A 402
ASP A 386
 None
 0.71A 4a6eA-4wzbA:
2.2		 4a6eA-4wzbA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgc ORIGIN RECOGNITION
COMPLEX SUBUNIT 1

(Drosophila
melanogaster) 		PF00004
(AAA)
PF09079
(Cdc6_C) 		3 TYR A 595
ASP A 687
ASP A 684
 None
 0.73A 4a6eA-4xgcA:
4.4		 4a6eA-4xgcA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xrl MITOGEN-ACTIVATED
PROTEIN KINASE 1

(Rattus
norvegicus) 		PF00069
(Pkinase) 		3 TYR A 314
ASP A 122
ASP A 281
 None
 0.88A 4a6eA-4xrlA:
undetectable		 4a6eA-4xrlA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yvs CAPSID PROTEIN VP0

(Enterovirus A) 		PF00073
(Rhv) 		3 TYR C 148
ASP C  84
ASP C 156
 None
 0.81A 4a6eA-4yvsC:
undetectable		 4a6eA-4yvsC:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zju ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH]

(Acinetobacter
baumannii) 		PF13561
(adh_short_C2) 		3 TYR A 124
ASP A  70
ASP A  66
 None
None
NAD  A 300 (-3.7A)
 0.83A 4a6eA-4zjuA:
5.0		 4a6eA-4zjuA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5awp ISOMALTODEXTRANASE

(Arthrobacter
globiformis) 		no annotation 3 TYR A  36
ASP A 310
ASP A 258
 None
 0.65A 4a6eA-5awpA:
undetectable		 4a6eA-5awpA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fq6 PUTATIVE LIPOPROTEIN

(Bacteroides
thetaiotaomicron) 		PF12771
(SusD-like_2) 		3 TYR A 388
ASP A 195
ASP A 478
 None
 0.82A 4a6eA-5fq6A:
undetectable		 4a6eA-5fq6A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5inw PUTATIVE
ANGIOTENSINOGEN

(Lampetra
fluviatilis) 		PF00079
(Serpin) 		3 TYR A 374
ASP A 390
ASP A 236
 None
 0.76A 4a6eA-5inwA:
undetectable		 4a6eA-5inwA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j6b ALDEHYDE
DEHYDROGENASE

(Burkholderia
thailandensis) 		PF00171
(Aldedh) 		3 TYR A   8
ASP A  39
ASP A  44
 None
 0.73A 4a6eA-5j6bA:
3.6		 4a6eA-5j6bA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jry NAD-DEPENDENT
ALDEHYDE
DEHYDROGENASE

(Burkholderia
multivorans) 		PF00171
(Aldedh) 		3 TYR A   8
ASP A  39
ASP A  44
 None
 0.74A 4a6eA-5jryA:
3.5		 4a6eA-5jryA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kj2 HISTONE
ACETYLTRANSFERASE
P300

(Homo sapiens) 		PF08214
(HAT_KAT11) 		3 TYR A1397
ASP A1628
ASP A1625
 None
 0.64A 4a6eA-5kj2A:
undetectable		 4a6eA-5kj2A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5koj NITROGENASE PROTEIN
ALPHA CHAIN

(Gluconacetobacter
diazotrophicus) 		PF00148
(Oxidored_nitro) 		3 TYR A 370
ASP A 418
ASP A 402
 None
 0.68A 4a6eA-5kojA:
undetectable		 4a6eA-5kojA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lx8 SUSD HOMOLOG

(Bacteroides
thetaiotaomicron) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		3 TYR A 254
ASP A 201
ASP A 194
 None
 0.76A 4a6eA-5lx8A:
undetectable		 4a6eA-5lx8A:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mdn DNA POLYMERASE

(Pyrobaculum
calidifontis) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		3 TYR A 558
ASP A 562
ASP A 590
 None
 0.81A 4a6eA-5mdnA:
undetectable		 4a6eA-5mdnA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nd5 TRANSKETOLASE

(Chlamydomonas
reinhardtii) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		3 TYR A 335
ASP A 343
ASP A  53
 None
 0.88A 4a6eA-5nd5A:
3.5		 4a6eA-5nd5A:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u1s SEPARIN

(Saccharomyces
cerevisiae) 		PF03568
(Peptidase_C50) 		3 TYR A1361
ASP A1350
ASP A1343
 None
 0.85A 4a6eA-5u1sA:
undetectable		 4a6eA-5u1sA:
11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u7g CREB-BINDING PROTEIN

(Mus musculus) 		PF00439
(Bromodomain)
PF00569
(ZZ)
PF06001
(DUF902)
PF08214
(HAT_KAT11) 		3 TYR A1434
ASP A1666
ASP A1663
 None
 0.58A 4a6eA-5u7gA:
undetectable		 4a6eA-5u7gA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u7x NOD FACTOR BINDING
LECTIN-NUCLEOTIDE
PHOSPHOHYDROLASE

(Vigna
unguiculata) 		PF01150
(GDA1_CD39) 		3 TYR F 361
ASP F 366
ASP F 261
 None
 0.85A 4a6eA-5u7xF:
undetectable		 4a6eA-5u7xF:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vk4 PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE

(Neisseria
gonorrhoeae) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		3 TYR A 192
ASP A  84
ASP A  63
 None
None
MG  A 402 ( 3.6A)
 0.82A 4a6eA-5vk4A:
undetectable		 4a6eA-5vk4A:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xnc -

(-) 		no annotation 3 TYR A 295
ASP A 126
ASP A 344
 None
N4P  A 402 ( 3.6A)
None
 0.88A 4a6eA-5xncA:
8.8		 4a6eA-5xncA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xyn SUPPRESSOR OF HU
SENSITIVITY INVOLVED
IN RECOMBINATION
PROTEIN 1

(Saccharomyces
cerevisiae) 		no annotation 3 TYR C  94
ASP C  98
ASP C  31
 None
 0.86A 4a6eA-5xynC:
undetectable		 4a6eA-5xynC:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ze3 LYSYL OXIDASE
HOMOLOG 2

(Homo sapiens) 		no annotation 3 TYR A 744
ASP A 707
ASP A 737
 None
 0.54A 4a6eA-5ze3A:
undetectable		 4a6eA-5ze3A:
undetectable