SIMILAR PATTERNS OF AMINO ACIDS FOR 4A3U_B_ACTB1358_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dj0 PSEUDOURIDINE
SYNTHASE I

(Escherichia
coli) 		PF01416
(PseudoU_synth_1) 		4 PRO A 261
ARG A  98
GLY A  15
VAL A  69
 None
 0.87A 4a3uB-1dj0A:
undetectable		 4a3uB-1dj0A:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f8f BENZYL ALCOHOL
DEHYDROGENASE

(Acinetobacter
calcoaceticus) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 ILE A 271
GLY A 198
VAL A 221
SER A 242
 None
NAD  A 375 ( 4.0A)
None
NAD  A 375 ( 3.7A)
 0.85A 4a3uB-1f8fA:
undetectable		 4a3uB-1f8fA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ka0 HALOTOLERANCE
PROTEIN HAL2

(Saccharomyces
cerevisiae) 		PF00459
(Inositol_P) 		4 PRO A 143
GLN A  53
GLY A 128
VAL A  69
 NA  A 501 ( 4.8A)
None
None
None
 0.99A 4a3uB-1ka0A:
undetectable		 4a3uB-1ka0A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mir PROCATHEPSIN B

(Rattus
norvegicus) 		PF00112
(Peptidase_C1)
PF08127
(Propeptide_C1) 		4 PRO A 106
ILE A 105
GLY A 123
SER A  25
 None
 0.94A 4a3uB-1mirA:
undetectable		 4a3uB-1mirA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qox BETA-GLUCOSIDASE

(Bacillus
circulans) 		PF00232
(Glyco_hydro_1) 		4 PRO A 182
ILE A  34
GLN A 129
GLY A 133
 None
 0.97A 4a3uB-1qoxA:
14.5		 4a3uB-1qoxA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qpa LIGNIN PEROXIDASE

(Phanerochaete
chrysosporium) 		PF00141
(peroxidase)
PF11895
(Peroxidase_ext) 		4 PRO A 290
ILE A 289
GLY A 116
VAL A 117
 None
 0.93A 4a3uB-1qpaA:
undetectable		 4a3uB-1qpaA:
25.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s1d APYRASE

(Homo sapiens) 		PF06079
(Apyrase) 		4 PRO A 208
ARG A 236
GLY A 168
VAL A 170
 None
 0.94A 4a3uB-1s1dA:
undetectable		 4a3uB-1s1dA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sei RIBOSOMAL PROTEIN S8

(Geobacillus
stearothermophilus) 		PF00410
(Ribosomal_S8) 		4 ILE A  13
ARG A  14
GLY A  74
VAL A 129
 None
 0.83A 4a3uB-1seiA:
undetectable		 4a3uB-1seiA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sxj ACTIVATOR 1 95 KDA
SUBUNIT

(Saccharomyces
cerevisiae) 		PF00004
(AAA)
PF08519
(RFC1) 		4 PRO A 354
ILE A 357
ARG A 477
GLY A 512
 None
AGS  A 801 (-4.4A)
None
None
 1.00A 4a3uB-1sxjA:
undetectable		 4a3uB-1sxjA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tr1 BETA-GLUCOSIDASE A

(Paenibacillus
polymyxa) 		PF00232
(Glyco_hydro_1) 		4 PRO A 182
ILE A  34
GLN A 129
GLY A 133
 None
 0.97A 4a3uB-1tr1A:
13.5		 4a3uB-1tr1A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wcg THIOGLUCOSIDASE

(Brevicoryne
brassicae) 		PF00232
(Glyco_hydro_1) 		4 PRO A 182
ILE A  33
GLN A 130
GLY A 134
 None
 1.00A 4a3uB-1wcgA:
14.0		 4a3uB-1wcgA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xkt FATTY ACID SYNTHASE

(Homo sapiens) 		PF00975
(Thioesterase) 		4 PRO A2301
GLN A2297
ARG A2242
VAL A2304
 None
 0.97A 4a3uB-1xktA:
undetectable		 4a3uB-1xktA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a2l UNKNOWN

(Klebsiella
pneumoniae) 		PF03928
(Haem_degrading) 		4 ILE A  32
GLN A 130
GLY A 126
VAL A  36
 None
 0.93A 4a3uB-2a2lA:
undetectable		 4a3uB-2a2lA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b4q RHAMNOLIPIDS
BIOSYNTHESIS
3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE

(Pseudomonas
aeruginosa) 		PF13561
(adh_short_C2) 		4 ILE A 217
ARG A 194
GLY A 193
VAL A 149
 None
None
NAP  A1901 (-4.7A)
None
 0.97A 4a3uB-2b4qA:
undetectable		 4a3uB-2b4qA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c3z INDOLE-3-GLYCEROL
PHOSPHATE SYNTHASE

(Sulfolobus
solfataricus) 		PF00218
(IGPS) 		4 PRO A 106
ILE A  31
ARG A  36
SER A 104
 None
 0.96A 4a3uB-2c3zA:
11.9		 4a3uB-2c3zA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dr3 UPF0273 PROTEIN
PH0284

(Pyrococcus
horikoshii) 		PF06745
(ATPase) 		4 PRO A  10
ILE A   9
GLN A  42
GLY A 230
 None
 0.94A 4a3uB-2dr3A:
2.8		 4a3uB-2dr3A:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fqz R.ECL18KI

(Enterobacter
cloacae) 		PF09019
(EcoRII-C) 		4 ILE A 275
GLN A 168
GLY A 165
SER A 278
 None
 0.87A 4a3uB-2fqzA:
undetectable		 4a3uB-2fqzA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hi0 PUTATIVE
PHOSPHOGLYCOLATE
PHOSPHATASE

(Lactobacillus
delbrueckii) 		PF13419
(HAD_2) 		4 PRO A 165
ILE A 192
GLY A  74
VAL A  53
 None
None
EDO  A 247 (-3.4A)
EDO  A 247 ( 4.7A)
 0.92A 4a3uB-2hi0A:
undetectable		 4a3uB-2hi0A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ija ARYLAMINE
N-ACETYLTRANSFERASE
1

(Homo sapiens) 		PF00797
(Acetyltransf_2) 		4 ILE A  32
GLN A 130
GLY A 124
VAL A  71
 None
 1.01A 4a3uB-2ijaA:
undetectable		 4a3uB-2ijaA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ozg GCN5-RELATED
N-ACETYLTRANSFERASE

(Trichormus
variabilis) 		PF13527
(Acetyltransf_9)
PF13530
(SCP2_2) 		4 PRO A 239
GLN A 212
GLY A 206
SER A 243
 None
 0.85A 4a3uB-2ozgA:
undetectable		 4a3uB-2ozgA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pfr ARYLAMINE
N-ACETYLTRANSFERASE
2

(Homo sapiens) 		PF00797
(Acetyltransf_2) 		4 ILE A  32
GLN A 130
GLY A 124
VAL A  71
 None
 1.00A 4a3uB-2pfrA:
undetectable		 4a3uB-2pfrA:
23.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2q3o 12-OXOPHYTODIENOATE
REDUCTASE 3

(Arabidopsis
thaliana) 		PF00724
(Oxidored_FMN) 		4 PRO A  31
ILE A  61
ARG A 238
SER A 341
 FMN  A7401 (-4.3A)
None
FMN  A7401 (-3.7A)
None
 0.44A 4a3uB-2q3oA:
52.3		 4a3uB-2q3oA:
39.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rdx MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME,
PUTATIVE

(Roseovarius
nubinhibens) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 PRO A  52
GLY A  64
VAL A  65
SER A  34
 None
 0.98A 4a3uB-2rdxA:
6.4		 4a3uB-2rdxA:
25.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vro ALDEHYDE
DEHYDROGENASE

(Paraburkholderia
xenovorans) 		PF00171
(Aldedh) 		4 ILE A 465
GLN A 473
GLY A 475
SER A 439
 None
 0.99A 4a3uB-2vroA:
undetectable		 4a3uB-2vroA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zts PUTATIVE
UNCHARACTERIZED
PROTEIN PH0186

(Pyrococcus
horikoshii) 		PF06745
(ATPase) 		4 PRO A  17
ILE A  16
GLN A  49
GLY A 241
 None
 1.00A 4a3uB-2ztsA:
3.1		 4a3uB-2ztsA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a5f DIHYDRODIPICOLINATE
SYNTHASE

(Clostridium
botulinum) 		PF00701
(DHDPS) 		4 PRO A  73
ILE A  72
GLY A   8
VAL A   9
 None
 1.00A 4a3uB-3a5fA:
8.2		 4a3uB-3a5fA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b13 DEDICATOR OF
CYTOKINESIS PROTEIN
2

(Homo sapiens) 		PF06920
(DHR-2) 		4 PRO A1394
GLN A1407
GLY A1346
VAL A1360
 None
 0.81A 4a3uB-3b13A:
undetectable		 4a3uB-3b13A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b5i S-ADENOSYL-L-METHION
INE:SALICYLIC ACID
CARBOXYL
METHYLTRANSFERASE-LI
KE PROTEIN

(Arabidopsis
thaliana) 		PF03492
(Methyltransf_7) 		4 ARG A 324
GLY A 328
VAL A 331
SER A 340
 None
 0.81A 4a3uB-3b5iA:
undetectable		 4a3uB-3b5iA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bg2 DGTP
TRIPHOSPHOHYDROLASE

(Leeuwenhoekiella
blandensis) 		PF01966
(HD) 		4 GLN A  24
ARG A  19
GLY A  30
VAL A  33
 None
 0.93A 4a3uB-3bg2A:
undetectable		 4a3uB-3bg2A:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cai POSSIBLE
AMINOTRANSFERASE

(Mycobacterium
tuberculosis) 		PF00266
(Aminotran_5) 		4 PRO A  31
ILE A  30
GLY A 266
VAL A  38
 None
 0.98A 4a3uB-3caiA:
undetectable		 4a3uB-3caiA:
24.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ge5 PUTATIVE NAD(P)H:FMN
OXIDOREDUCTASE

(Porphyromonas
gingivalis) 		PF00881
(Nitroreductase) 		4 ILE A 137
ARG A  66
GLY A  63
VAL A  58
 None
 1.00A 4a3uB-3ge5A:
undetectable		 4a3uB-3ge5A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h4h COPPER-CONTAINING
NITRITE REDUCTASE

(Alcaligenes
faecalis) 		PF00394
(Cu-oxidase)
PF07732
(Cu-oxidase_3) 		4 PRO A 284
ILE A 283
GLY A 268
VAL A 131
 None
 1.00A 4a3uB-3h4hA:
undetectable		 4a3uB-3h4hA:
22.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3hgo 12-OXOPHYTODIENOATE
REDUCTASE 3

(Solanum
lycopersicum) 		PF00724
(Oxidored_FMN) 		4 PRO A  31
ILE A  61
ARG A 237
SER A 340
 FMN  A 401 (-3.9A)
None
FMN  A 401 (-2.9A)
None
 0.41A 4a3uB-3hgoA:
53.4		 4a3uB-3hgoA:
37.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ifq PLAKOGLOBIN
E-CADHERIN

(Homo sapiens;
Mus musculus) 		PF00514
(Arm)
PF01049
(Cadherin_C) 		4 PRO C 672
ARG A 506
GLY A 565
VAL A 603
 None
 0.99A 4a3uB-3ifqC:
undetectable		 4a3uB-3ifqC:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kwu MUNC13-1

(Rattus
norvegicus) 		PF00168
(C2) 		5 GLN A 780
ARG A 801
GLY A 779
VAL A 807
SER A 805
 None
None
None
None
CL  A 911 (-4.4A)
 1.23A 4a3uB-3kwuA:
undetectable		 4a3uB-3kwuA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kyl TELOMERASE REVERSE
TRANSCRIPTASE

(Tribolium
castaneum) 		PF00078
(RVT_1)
PF12009
(Telomerase_RBD) 		4 ILE A 288
GLN A 291
GLY A 305
VAL A 259
 None
 0.89A 4a3uB-3kylA:
undetectable		 4a3uB-3kylA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m1l 3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
REDUCTASE

(Mycobacterium
tuberculosis) 		PF13561
(adh_short_C2) 		4 ILE A  93
GLN A 138
GLY A 123
VAL A 121
 None
 0.92A 4a3uB-3m1lA:
2.3		 4a3uB-3m1lA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m7f E3 UBIQUITIN-PROTEIN
LIGASE NEDD4

(Mus musculus) 		PF00168
(C2) 		4 GLN B 205
GLY B 204
VAL B 240
SER B 238
 None
 0.99A 4a3uB-3m7fB:
undetectable		 4a3uB-3m7fB:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o14 ANTI-ECFSIGMA
FACTOR, CHRR

(Marinobacter
hydrocarbonoclasticus) 		PF12973
(Cupin_7) 		4 PRO A  51
GLY A  71
VAL A  72
SER A  98
 None
 0.94A 4a3uB-3o14A:
undetectable		 4a3uB-3o14A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ogr BETA-GALACTOSIDASE

(Trichoderma
reesei) 		PF01301
(Glyco_hydro_35)
PF10435
(BetaGal_dom2)
PF13363
(BetaGal_dom3)
PF13364
(BetaGal_dom4_5) 		4 PRO A1000
ILE A 922
VAL A 674
SER A 997
 None
 0.90A 4a3uB-3ogrA:
10.6		 4a3uB-3ogrA:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qfk UNCHARACTERIZED
PROTEIN

(Staphylococcus
aureus) 		PF00149
(Metallophos)
PF02872
(5_nucleotid_C) 		4 ILE A 236
GLN A 247
ARG A 234
GLY A 193
 None
 0.90A 4a3uB-3qfkA:
2.3		 4a3uB-3qfkA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t6c PUTATIVE MAND FAMILY
DEHYDRATASE

(Pantoea
ananatis) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 ILE A 385
GLY A  37
VAL A  23
SER A 331
 None
 0.87A 4a3uB-3t6cA:
6.1		 4a3uB-3t6cA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tav METHIONINE
AMINOPEPTIDASE

(Mycobacteroides
abscessus) 		PF00557
(Peptidase_M24) 		4 ARG A 264
GLY A  30
VAL A  29
SER A 116
 None
 1.00A 4a3uB-3tavA:
undetectable		 4a3uB-3tavA:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tma METHYLTRANSFERASE

(Thermus
thermophilus) 		PF01170
(UPF0020)
PF02926
(THUMP) 		4 PRO A  83
ARG A  61
GLY A 147
VAL A 135
 None
 0.87A 4a3uB-3tmaA:
undetectable		 4a3uB-3tmaA:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u4j NAD-DEPENDENT
ALDEHYDE
DEHYDROGENASE

(Sinorhizobium
meliloti) 		PF00171
(Aldedh) 		4 ILE A 401
GLY A 299
VAL A 294
SER A 306
 None
 1.00A 4a3uB-3u4jA:
2.2		 4a3uB-3u4jA:
23.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3wjs NADH OXIDASE

(Gluconobacter
oxydans) 		PF00724
(Oxidored_FMN) 		4 ILE A  53
GLN A 170
ARG A 224
VAL A 290
 None
 0.54A 4a3uB-3wjsA:
44.9		 4a3uB-3wjsA:
69.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3wjs NADH OXIDASE

(Gluconobacter
oxydans) 		PF00724
(Oxidored_FMN) 		4 PRO A  12
ARG A 220
GLY A 168
VAL A  96
 None
PGE  A 401 (-3.7A)
None
None
 0.83A 4a3uB-3wjsA:
44.9		 4a3uB-3wjsA:
69.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4a3u NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE

(Zymomonas
mobilis) 		PF00724
(Oxidored_FMN) 		7 PRO A  23
ILE A  53
GLN A 170
ARG A 224
GLY A 259
VAL A 290
SER A 313
 FMN  A1357 (-4.2A)
ACT  A1358 (-4.7A)
ACT  A1358 (-3.3A)
FMN  A1357 ( 3.0A)
ACT  A1358 (-3.6A)
ACT  A1358 ( 4.8A)
ACT  A1358 (-2.4A)
 0.20A 4a3uB-4a3uA:
65.8		 4a3uB-4a3uA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b3i FATTY ACID
BETA-OXIDATION
COMPLEX ALPHA-CHAIN
FADB

(Mycobacterium
tuberculosis) 		PF00378
(ECH_1)
PF00725
(3HCDH)
PF02737
(3HCDH_N) 		4 ILE A 340
GLY A 329
VAL A 351
SER A 344
 None
 0.95A 4a3uB-4b3iA:
2.2		 4a3uB-4b3iA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dkm AMPHIOXUS GREEN
FLUORESCENT PROTEIN,
GFPC1A

(Branchiostoma
floridae) 		PF01353
(GFP) 		4 ILE A  90
ARG A  88
GLY A 100
VAL A 117
 None
CR2  A  60 ( 2.8A)
None
None
 0.99A 4a3uB-4dkmA:
undetectable		 4a3uB-4dkmA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dqa UNCHARACTERIZED
PROTEIN

(Bacteroides
ovatus) 		PF08522
(DUF1735)
PF13385
(Laminin_G_3) 		4 ILE A 278
GLN A 235
GLY A 234
VAL A 211
 None
 1.00A 4a3uB-4dqaA:
undetectable		 4a3uB-4dqaA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f85 GERANYL DIPHOSPHATE
2-C-METHYLTRANSFERAS
E

(Streptomyces
lasaliensis) 		PF02353
(CMAS) 		4 PRO A 168
ARG A 160
GLY A 133
VAL A 110
 None
 0.97A 4a3uB-4f85A:
undetectable		 4a3uB-4f85A:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fcs VERSATILE PEROXIDASE
VPL2

(Pleurotus
eryngii) 		PF00141
(peroxidase)
PF11895
(Peroxidase_ext) 		4 ILE A 254
GLN A 251
GLY A 116
VAL A 118
 None
 1.00A 4a3uB-4fcsA:
undetectable		 4a3uB-4fcsA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hnl MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME

(Enterococcus
gallinarum) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 ILE A 367
GLY A  36
VAL A  23
SER A 313
 None
 0.98A 4a3uB-4hnlA:
6.0		 4a3uB-4hnlA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ihc MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN

(Dickeya
paradisiaca) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 ILE A 385
GLY A  37
VAL A  23
SER A 331
 None
 0.88A 4a3uB-4ihcA:
5.7		 4a3uB-4ihcA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jzj INTERLEUKIN-3
RECEPTOR SUBUNIT
ALPHA

(Homo sapiens) 		PF09240
(IL6Ra-bind) 		4 PRO C 193
ILE C 192
GLY C 127
VAL C 126
 None
 1.01A 4a3uB-4jzjC:
undetectable		 4a3uB-4jzjC:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4krf PROTEIN ARGONAUTE-1

(Homo sapiens) 		PF02170
(PAZ)
PF02171
(Piwi)
PF08699
(ArgoL1)
PF16486
(ArgoN)
PF16487
(ArgoMid)
PF16488
(ArgoL2) 		4 PRO A 729
ILE A 728
GLY A 408
VAL A 734
 None
 0.97A 4a3uB-4krfA:
2.4		 4a3uB-4krfA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m8n PLEXINC1
INTRACELLULAR REGION
RAS-RELATED PROTEIN
RAP-1B

(Danio rerio;
Homo sapiens) 		PF08337
(Plexin_cytopl)
PF00071
(Ras) 		5 PRO E  34
GLN E  63
ARG A 711
GLY E  12
VAL E  14
 AF3  E 202 ( 4.3A)
AF3  E 202 (-3.5A)
GDP  E 201 ( 2.9A)
AF3  E 202 (-3.5A)
GDP  E 201 (-4.3A)
 1.48A 4a3uB-4m8nE:
undetectable		 4a3uB-4m8nE:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mee DIFFUSE ADHERENCE
ADHESIN

(Escherichia
coli) 		PF03797
(Autotransporter) 		4 PRO A 965
GLY A1115
VAL A1113
SER A 969
 None
 0.97A 4a3uB-4meeA:
undetectable		 4a3uB-4meeA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mkn TRIOSEPHOSPHATE
ISOMERASE

(Chlamydomonas
reinhardtii) 		PF00121
(TIM) 		4 ILE A 124
GLY A   9
VAL A  40
SER A  62
 None
 0.88A 4a3uB-4mknA:
5.6		 4a3uB-4mknA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mzd NISIN LEADER
PEPTIDE-PROCESSING
SERINE PROTEASE NISP

(Lactococcus
lactis) 		PF00082
(Peptidase_S8) 		4 ILE A 314
GLY A 256
VAL A 359
SER A 519
 None
 1.00A 4a3uB-4mzdA:
undetectable		 4a3uB-4mzdA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nar PUTATIVE URONATE
ISOMERASE

(Thermotoga
maritima) 		PF09861
(DUF2088) 		4 PRO A 189
ILE A 188
GLN A 293
GLY A 358
 None
 0.99A 4a3uB-4narA:
undetectable		 4a3uB-4narA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ohq TRIOSEPHOSPHATE
ISOMERASE,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF00121
(TIM) 		4 ILE A 125
GLY A  10
VAL A  41
SER A  63
 None
 0.87A 4a3uB-4ohqA:
7.1		 4a3uB-4ohqA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pdb 30S RIBOSOMAL
PROTEIN S8

(Bacillus
anthracis) 		PF00410
(Ribosomal_S8) 		4 ILE A  37
ARG A  38
GLY A  99
VAL A 154
 None
 0.83A 4a3uB-4pdbA:
undetectable		 4a3uB-4pdbA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pe6 PUTATIVE ABC
TRANSPORTER

(Thermobispora
bispora) 		PF13407
(Peripla_BP_4) 		4 PRO A 260
ILE A 259
GLY A 245
SER A 283
 None
 0.99A 4a3uB-4pe6A:
undetectable		 4a3uB-4pe6A:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ptx GLYCOSIDE HYDROLASE
FAMILY 1

(Halothermothrix
orenii) 		PF00232
(Glyco_hydro_1) 		4 PRO A 182
ILE A  34
GLN A 129
GLY A 133
 None
 0.97A 4a3uB-4ptxA:
14.2		 4a3uB-4ptxA:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pz2 ZMALDH

(Zea mays) 		PF00171
(Aldedh) 		5 PRO A 421
ILE A 399
GLN A 360
GLY A 358
VAL A 346
 None
 1.49A 4a3uB-4pz2A:
2.0		 4a3uB-4pz2A:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rl3 CHITINASE A

(Pteris
ryukyuensis) 		PF00704
(Glyco_hydro_18) 		4 ILE A 154
GLY A 241
VAL A 276
SER A 278
 None
 1.00A 4a3uB-4rl3A:
10.8		 4a3uB-4rl3A:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u48 PUTATIVE INNER
MEMBRANE LIPOPROTEIN

(Salmonella
enterica) 		PF00207
(A2M)
PF01835
(A2M_N)
PF07703
(A2M_N_2)
PF10569
(Thiol-ester_cl)
PF11974
(MG1) 		4 ARG A1030
GLY A1613
VAL A1642
SER A1517
 None
 0.94A 4a3uB-4u48A:
undetectable		 4a3uB-4u48A:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xv0 BETA-XYLANASE

(Trichoderma
reesei) 		PF00331
(Glyco_hydro_10) 		4 PRO A 289
ILE A 285
GLY A 260
VAL A 296
 None
 0.90A 4a3uB-4xv0A:
10.2		 4a3uB-4xv0A:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yxm DNA INTEGRITY
SCANNING PROTEIN
DISA

(Thermotoga
maritima) 		PF00633
(HHH)
PF02457
(DisA_N)
PF10635
(DisA-linker) 		5 PRO A 304
ILE A 303
ARG A 339
GLY A 334
SER A 306
 None
 1.48A 4a3uB-4yxmA:
undetectable		 4a3uB-4yxmA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zh7 OUTER MEMBRANE
PROTEIN-ADHESIN

(Helicobacter
pylori) 		no annotation 4 PRO A 278
ILE A 300
GLY A 101
VAL A 103
 None
 0.99A 4a3uB-4zh7A:
undetectable		 4a3uB-4zh7A:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zjg ALPHA-2-MACROGLOBULI
N

(Escherichia
coli) 		PF11974
(MG1) 		4 ILE A 319
GLN A 316
GLY A 293
VAL A 294
 None
 0.99A 4a3uB-4zjgA:
undetectable		 4a3uB-4zjgA:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c2k TRANSFORMING PROTEIN
RHOA,RAC
GTPASE-ACTIVATING
PROTEIN 1

(Homo sapiens) 		PF00071
(Ras)
PF00620
(RhoGAP) 		4 PRO A  36
GLN A  63
ARG A 247
GLY A  14
 AF3  A 502 (-4.5A)
AF3  A 502 (-3.2A)
GDP  A 503 ( 3.5A)
AF3  A 502 (-3.3A)
 0.90A 4a3uB-5c2kA:
undetectable		 4a3uB-5c2kA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cg0 BETA-GLUCOSIDASE

(Spodoptera
frugiperda) 		PF00232
(Glyco_hydro_1) 		4 PRO A 203
ILE A  53
GLN A 150
GLY A 154
 None
 1.01A 4a3uB-5cg0A:
12.8		 4a3uB-5cg0A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fac ALANINE RACEMASE

(Streptomyces
coelicolor) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		4 PRO A 307
ILE A 306
GLY A 314
VAL A 325
 None
 0.87A 4a3uB-5facA:
3.7		 4a3uB-5facA:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5feu NOROXOMARITIDINE/NOR
CRAUGSODINE
REDUCTASE

(Narcissus
pseudonarcissus) 		PF13561
(adh_short_C2) 		4 ILE A 235
ARG A 234
GLY A 233
VAL A 230
 None
 0.91A 4a3uB-5feuA:
3.1		 4a3uB-5feuA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ff9 NOROXOMARITIDINE/NOR
CRAUGSODINE
REDUCTASE

(Narcissus
pseudonarcissus) 		PF13561
(adh_short_C2) 		4 ILE A 235
ARG A 234
GLY A 233
VAL A 230
 None
 0.98A 4a3uB-5ff9A:
2.1		 4a3uB-5ff9A:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fhz ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3

(Homo sapiens) 		PF00171
(Aldedh) 		5 PRO A 415
ILE A 393
GLN A 356
GLY A 354
VAL A 343
 None
 1.38A 4a3uB-5fhzA:
undetectable		 4a3uB-5fhzA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gam PRE-MRNA-SPLICING
FACTOR 8

(Saccharomyces
cerevisiae) 		PF08082
(PRO8NT)
PF08083
(PROCN) 		4 ILE A 346
GLY A 339
VAL A 385
SER A 381
 None
 0.93A 4a3uB-5gamA:
undetectable		 4a3uB-5gamA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i6c URIC ACID-XANTHINE
PERMEASE

(Aspergillus
nidulans) 		PF00860
(Xan_ur_permease) 		4 PRO A 448
ILE A 447
GLY A 305
VAL A 278
 None
 0.80A 4a3uB-5i6cA:
undetectable		 4a3uB-5i6cA:
21.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5k1u NAD(P)H:FLAVIN
OXIDOREDUCTASE SYE4

(Shewanella
oneidensis) 		PF00724
(Oxidored_FMN) 		4 PRO A  33
ILE A  63
ARG A 234
VAL A 299
 FMN  A 400 (-3.7A)
None
FMN  A 400 (-2.9A)
None
 0.61A 4a3uB-5k1uA:
49.4		 4a3uB-5k1uA:
38.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l8v DNA REPAIR AND
RECOMBINATION
PROTEIN RADA

(Pyrococcus
furiosus) 		PF08423
(Rad51) 		4 ILE A 277
ARG A 226
GLY A 166
VAL A 155
 None
 0.98A 4a3uB-5l8vA:
undetectable		 4a3uB-5l8vA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lc5 NADH DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR PROTEIN
2, MITOCHONDRIAL

(Bos taurus) 		PF00346
(Complex1_49kDa) 		4 ILE D 417
GLN D 421
GLY D 401
SER D 406
 None
 0.99A 4a3uB-5lc5D:
undetectable		 4a3uB-5lc5D:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nh0 REPLICASE
POLYPROTEIN 1AB

(Human
coronavirus
NL63) 		no annotation 4 PRO A  39
GLY A 174
VAL A 181
SER A  84
 None
 0.93A 4a3uB-5nh0A:
undetectable		 4a3uB-5nh0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ns8 -

(-) 		no annotation 4 PRO A 180
ILE A  32
GLN A 127
GLY A 131
 None
 0.96A 4a3uB-5ns8A:
14.0		 4a3uB-5ns8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o96 RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E

(Legionella
pneumophila) 		no annotation 4 ILE A  82
GLN A 238
GLY A 241
VAL A 186
 None
 0.99A 4a3uB-5o96A:
undetectable		 4a3uB-5o96A:
20.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ocs PUTATIVE
NADH-DEPENTDENT
FLAVIN
OXIDOREDUCTASE

(Cupriavidus
metallidurans) 		PF00724
(Oxidored_FMN) 		4 PRO A  23
ILE A  54
ARG A 231
SER A 322
 FMN  A 401 (-4.1A)
None
FMN  A 401 (-2.8A)
None
 0.41A 4a3uB-5ocsA:
38.4		 4a3uB-5ocsA:
30.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ogz -

(-) 		no annotation 4 PRO A 182
ILE A  34
GLN A 129
GLY A 133
 None
 1.00A 4a3uB-5ogzA:
12.9		 4a3uB-5ogzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t3a INTEGRASE

(Visna-maedi
virus) 		PF00665
(rve) 		4 PRO A 144
ILE A 143
GLN A 116
VAL A 153
 None
 0.98A 4a3uB-5t3aA:
undetectable		 4a3uB-5t3aA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ufh LACI-TYPE
TRANSCRIPTIONAL
REGULATOR

(Bifidobacterium
animalis) 		PF13377
(Peripla_BP_3) 		4 PRO A 303
ILE A 305
VAL A 158
SER A 332
 None
None
None
NO3  A 408 ( 4.9A)
 0.99A 4a3uB-5ufhA:
undetectable		 4a3uB-5ufhA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5van BETA-KLOTHO

(Homo sapiens) 		no annotation 4 PRO A 257
ILE A 109
GLN A 203
GLY A 208
 None
 0.98A 4a3uB-5vanA:
8.1		 4a3uB-5vanA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vwn TRIOSEPHOSPHATE
ISOMERASE

(Trichomonas
vaginalis) 		no annotation 4 ILE A 117
GLY A   7
VAL A  39
SER A  61
 None
 0.95A 4a3uB-5vwnA:
6.7		 4a3uB-5vwnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w21 KLOTHO

(Homo sapiens) 		no annotation 4 PRO A 255
ILE A  89
GLN A 201
GLY A 206
 None
 1.00A 4a3uB-5w21A:
8.5		 4a3uB-5w21A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wea PROTEIN ARGONAUTE-2

(Homo sapiens) 		no annotation 4 PRO A 731
ILE A 730
GLY A 410
VAL A 736
 None
 0.96A 4a3uB-5weaA:
2.3		 4a3uB-5weaA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wi9 -

(-) 		no annotation 4 PRO A 257
ILE A 109
GLN A 203
GLY A 208
 None
 1.00A 4a3uB-5wi9A:
12.8		 4a3uB-5wi9A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xxu RIBOSOMAL PROTEIN
US5
RIBOSOMAL PROTEIN
ES21

(Toxoplasma
gondii;
Toxoplasma
gondii) 		PF00333
(Ribosomal_S5)
PF03719
(Ribosomal_S5_C)
PF01249
(Ribosomal_S21e) 		4 PRO V  25
ILE V  24
GLY V  30
SER C  62
 None
 0.88A 4a3uB-5xxuV:
undetectable		 4a3uB-5xxuV:
12.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zq6 SIDE

(Legionella
pneumophila) 		no annotation 4 PRO A1056
ILE A1055
GLY A1027
VAL A1024
 None
 0.95A 4a3uB-5zq6A:
undetectable		 4a3uB-5zq6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f42 DNA-DIRECTED RNA
POLYMERASE III
SUBUNIT RPC2

(Saccharomyces
cerevisiae) 		no annotation 4 ILE B 959
GLY B 976
VAL B 736
SER B 963
 None
 0.91A 4a3uB-6f42B:
undetectable		 4a3uB-6f42B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fcx METHYLENETETRAHYDROF
OLATE REDUCTASE

(Homo sapiens) 		no annotation 4 PRO A 502
GLY A 562
VAL A 507
SER A 493
 None
 0.81A 4a3uB-6fcxA:
8.5		 4a3uB-6fcxA:
undetectable