SIMILAR PATTERNS OF AMINO ACIDS FOR 3ZTV_A_ADNA1600

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
13pk 3-PHOSPHOGLYCERATE
KINASE

(Trypanosoma
brucei) 		PF00162
(PGK) 		5 GLY A 375
GLY A 376
ASN A  36
GLY A 397
TYR A  38
 ADP  A 421 (-3.3A)
ADP  A 421 (-4.0A)
None
None
None
 0.90A 3ztvA-13pkA:
undetectable		 3ztvA-13pkA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aog TRYPANOTHIONE
REDUCTASE

(Trypanosoma
cruzi) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 GLY A  14
GLY A  17
SER A  47
GLY A  51
ASP A  36
 FAD  A 492 (-3.3A)
None
FAD  A 492 (-2.5A)
FAD  A 492 (-3.2A)
FAD  A 492 (-3.2A)
 0.88A 3ztvA-1aogA:
undetectable		 3ztvA-1aogA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d6m DNA TOPOISOMERASE
III

(Escherichia
coli) 		PF01131
(Topoisom_bac)
PF01751
(Toprim) 		5 GLY A 102
ASN A 135
GLY A 108
TYR A 328
ASP A 105
 None
 1.29A 3ztvA-1d6mA:
undetectable		 3ztvA-1d6mA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fsu N-ACETYLGALACTOSAMIN
E-4-SULFATASE

(Homo sapiens) 		PF00884
(Sulfatase) 		5 ASN A 301
GLY A 302
GLY A 303
SER A 320
GLY A 325
 CA  A 604 ( 2.9A)
None
None
None
None
 1.32A 3ztvA-1fsuA:
undetectable		 3ztvA-1fsuA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fux HYPOTHETICAL 19.5
KDA PROTEIN IN
EMRE-RUS INTERGENIC
REGION

(Escherichia
coli) 		PF01161
(PBP) 		5 ASN A  29
GLY A 106
PHE A  99
ASN A  97
GLY A  27
 None
 1.29A 3ztvA-1fuxA:
undetectable		 3ztvA-1fuxA:
13.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h0h FORMATE
DEHYDROGENASE
SUBUNIT ALPHA

(Desulfovibrio
gigas) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		5 ASN A 177
GLY A 401
GLY A 402
GLY A 400
ASP A 181
 None
 1.27A 3ztvA-1h0hA:
undetectable		 3ztvA-1h0hA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hp1 5'-NUCLEOTIDASE

(Escherichia
coli) 		PF00149
(Metallophos)
PF02872
(5_nucleotid_C) 		6 GLY A 407
GLY A 408
PHE A 429
ASN A 431
GLY A 458
ASP A 504
 ATP  A 606 (-3.3A)
ATP  A 606 ( 4.2A)
ATP  A 606 (-3.8A)
ATP  A 606 (-3.1A)
ATP  A 606 (-3.6A)
ATP  A 606 (-2.8A)
 0.53A 3ztvA-1hp1A:
35.6		 3ztvA-1hp1A:
26.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kqf FORMATE
DEHYDROGENASE,
NITRATE-INDUCIBLE,
MAJOR SUBUNIT

(Escherichia
coli) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		5 ASN A 215
GLY A 440
GLY A 441
GLY A 439
ASP A 219
 None
 1.24A 3ztvA-1kqfA:
undetectable		 3ztvA-1kqfA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lxt PHOSPHOGLUCOMUTASE
(DEPHOSPHO FORM)

(Oryctolagus
cuniculus) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		5 ASN A 363
GLY A 362
ASN A 134
SER A 482
ASP A 480
 None
 1.32A 3ztvA-1lxtA:
undetectable		 3ztvA-1lxtA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lyb CATHEPSIN D

(Homo sapiens) 		PF00026
(Asp) 		5 GLY A  20
PHE A  28
SER A  64
GLY A  22
ASP A  90
 None
 1.32A 3ztvA-1lybA:
undetectable		 3ztvA-1lybA:
10.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1od3 PUTATIVE XYLANASE

([Clostridium]
stercorarium) 		PF03422
(CBM_6) 		5 GLY A  50
GLY A  49
GLY A  51
TYR A 115
ASP A 142
 None
None
None
None
CA  A1153 (-3.4A)
 1.17A 3ztvA-1od3A:
undetectable		 3ztvA-1od3A:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qs0 2-OXOISOVALERATE
DEHYDROGENASE
BETA-SUBUNIT

(Pseudomonas
putida) 		PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		5 GLY B 123
GLY B 124
SER B 134
GLY B 122
TYR B 322
 None
 1.28A 3ztvA-1qs0B:
undetectable		 3ztvA-1qs0B:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r53 CHORISMATE SYNTHASE

(Saccharomyces
cerevisiae) 		PF01264
(Chorismate_synt) 		5 ASN A 289
GLY A 292
GLY A 293
SER A 259
GLY A 258
 None
 1.10A 3ztvA-1r53A:
undetectable		 3ztvA-1r53A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ri3 MRNA CAPPING ENZYME

(Encephalitozoon
cuniculi) 		PF03291
(Pox_MCEL) 		5 GLY A  76
GLY A  77
ASN A  51
SER A  99
GLY A  74
 None
None
None
SAH  A 299 ( 4.2A)
SAH  A 299 (-3.5A)
 1.31A 3ztvA-1ri3A:
undetectable		 3ztvA-1ri3A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rk2 RIBOKINASE

(Escherichia
coli) 		PF00294
(PfkB) 		5 ASN A  46
GLY A  42
GLY A  41
GLY A  44
ASP A 255
 RIB  A 311 (-3.3A)
RIB  A 311 (-3.4A)
RIB  A 311 (-3.3A)
None
RIB  A 311 (-3.1A)
 1.03A 3ztvA-1rk2A:
undetectable		 3ztvA-1rk2A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rkr AZURIN-I

(Achromobacter
xylosoxidans) 		PF00127
(Copper-bind) 		5 GLY A  89
GLY A  88
ASN A  42
GLY A  37
ASP A  11
 None
 1.25A 3ztvA-1rkrA:
undetectable		 3ztvA-1rkrA:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1umb 2-OXO ACID
DEHYDROGENASE BETA
SUBUNIT

(Thermus
thermophilus) 		PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		5 GLY B 121
GLY B 122
SER B 132
GLY B 120
ASP B 262
 None
 1.15A 3ztvA-1umbB:
undetectable		 3ztvA-1umbB:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1umb 2-OXO ACID
DEHYDROGENASE BETA
SUBUNIT

(Thermus
thermophilus) 		PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		5 GLY B 121
GLY B 122
SER B 132
GLY B 120
TYR B 307
 None
 1.32A 3ztvA-1umbB:
undetectable		 3ztvA-1umbB:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1urh 3-MERCAPTOPYRUVATE
SULFURTRANSFERASE

(Escherichia
coli) 		PF00581
(Rhodanese) 		5 GLY A 120
GLY A 119
PHE A   5
GLY A  95
ASP A  93
 None
 0.92A 3ztvA-1urhA:
undetectable		 3ztvA-1urhA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vm7 RIBOKINASE

(Thermotoga
maritima) 		PF00294
(PfkB) 		5 ASN A  44
GLY A  40
GLY A  39
GLY A  42
ASP A 246
 None
 1.00A 3ztvA-1vm7A:
undetectable		 3ztvA-1vm7A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vpe PHOSPHOGLYCERATE
KINASE

(Thermotoga
maritima) 		PF00162
(PGK) 		5 GLY A 353
GLY A 354
ASN A 361
SER A 379
GLY A 376
 ANP  A 400 (-3.0A)
ANP  A 400 (-3.6A)
None
None
ANP  A 400 (-3.5A)
 1.25A 3ztvA-1vpeA:
undetectable		 3ztvA-1vpeA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aaf ARGININE DEIMINASE

(Pseudomonas
aeruginosa) 		PF02274
(Amidinotransf) 		5 ASN A 360
GLY A 403
GLY A 402
PHE A 163
GLY A 404
 CYR  A 406 ( 3.0A)
CYR  A 406 ( 4.6A)
CYR  A 406 ( 3.7A)
CYR  A 406 ( 3.9A)
CYR  A 406 ( 4.3A)
 1.23A 3ztvA-2aafA:
undetectable		 3ztvA-2aafA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2abq FRUCTOSE 1-PHOSPHATE
KINASE

(Bacillus
halodurans) 		PF00294
(PfkB) 		5 GLY A 246
PHE A 285
ASN A 243
GLY A  37
ASP A  12
 None
 1.28A 3ztvA-2abqA:
undetectable		 3ztvA-2abqA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ajr SUGAR KINASE, PFKB
FAMILY

(Thermotoga
maritima) 		PF00294
(PfkB) 		5 ASN A  44
GLY A  39
SER A 141
GLY A  42
ASP A 261
 ACT  A 321 (-3.9A)
ACT  A 321 ( 4.3A)
None
None
None
 1.05A 3ztvA-2ajrA:
undetectable		 3ztvA-2ajrA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ajr SUGAR KINASE, PFKB
FAMILY

(Thermotoga
maritima) 		PF00294
(PfkB) 		5 ASN A  44
GLY A  40
GLY A  39
SER A 141
ASP A 261
 ACT  A 321 (-3.9A)
ACT  A 321 (-3.9A)
ACT  A 321 ( 4.3A)
None
None
 1.16A 3ztvA-2ajrA:
undetectable		 3ztvA-2ajrA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cw6 HYDROXYMETHYLGLUTARY
L-COA LYASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00682
(HMGL-like) 		5 ASN A 275
GLY A 264
GLY A 265
GLY A  43
ASP A  42
 MG  A 401 (-2.8A)
None
None
None
MG  A 401 (-2.5A)
 1.34A 3ztvA-2cw6A:
2.0		 3ztvA-2cw6A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2elc ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Thermus
thermophilus) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N) 		5 ASN A 263
GLY A 258
GLY A 257
SER A 114
GLY A 259
 None
 1.21A 3ztvA-2elcA:
undetectable		 3ztvA-2elcA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f02 TAGATOSE-6-PHOSPHATE
KINASE

(Enterococcus
faecalis) 		PF00294
(PfkB) 		6 ASN A  41
GLY A  37
GLY A  36
SER A 134
GLY A  39
ASP A 255
 None
None
None
None
None
ATP  A 411 (-4.1A)
 1.39A 3ztvA-2f02A:
undetectable		 3ztvA-2f02A:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ie8 PHOSPHOGLYCERATE
KINASE

(Thermus
caldophilus) 		PF00162
(PGK) 		5 GLY A 347
GLY A 348
ASN A 355
SER A 373
GLY A 370
 None
 1.16A 3ztvA-2ie8A:
undetectable		 3ztvA-2ie8A:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jgv TAGATOSE-6-PHOSPHATE
KINASE

(Staphylococcus
aureus) 		PF00294
(PfkB) 		6 ASN A  41
GLY A  37
GLY A  36
SER A 134
GLY A  39
ASP A 254
 None
 1.37A 3ztvA-2jgvA:
undetectable		 3ztvA-2jgvA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nqo GAMMA-GLUTAMYLTRANSP
EPTIDASE

(Helicobacter
pylori) 		PF01019
(G_glu_transpept) 		5 ASN A  81
GLY A  84
GLY A  83
PHE A 231
GLY A  85
 None
 1.32A 3ztvA-2nqoA:
undetectable		 3ztvA-2nqoA:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pbg 6-PHOSPHO-BETA-D-GAL
ACTOSIDASE

(Lactococcus
lactis) 		PF00232
(Glyco_hydro_1) 		5 ASN A 316
GLY A 319
ASN A 431
GLY A 322
ASP A 346
 None
None
SO4  A 469 (-4.5A)
None
None
 1.24A 3ztvA-2pbgA:
0.9		 3ztvA-2pbgA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rd5 ACETYLGLUTAMATE
KINASE-LIKE PROTEIN

(Arabidopsis
thaliana) 		PF00696
(AA_kinase) 		5 PHE A 155
SER A 187
GLY A 188
TYR A 191
ASP A 185
 None
 1.23A 3ztvA-2rd5A:
undetectable		 3ztvA-2rd5A:
20.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2z1a 5'-NUCLEOTIDASE

(Thermus
thermophilus) 		PF00149
(Metallophos)
PF02872
(5_nucleotid_C) 		6 ASN A 378
GLY A 379
GLY A 381
ASN A 404
GLY A 432
ASP A 487
 THM  A6510 (-3.4A)
None
THM  A6510 (-3.6A)
THM  A6510 (-3.0A)
THM  A6510 (-3.2A)
THM  A6510 (-2.4A)
 1.16A 3ztvA-2z1aA:
42.3		 3ztvA-2z1aA:
32.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2z1a 5'-NUCLEOTIDASE

(Thermus
thermophilus) 		PF00149
(Metallophos)
PF02872
(5_nucleotid_C) 		7 ASN A 378
GLY A 380
GLY A 381
PHE A 402
ASN A 404
GLY A 432
ASP A 487
 THM  A6510 (-3.4A)
THM  A6510 (-4.1A)
THM  A6510 (-3.6A)
THM  A6510 (-3.7A)
THM  A6510 (-3.0A)
THM  A6510 (-3.2A)
THM  A6510 (-2.4A)
 0.36A 3ztvA-2z1aA:
42.3		 3ztvA-2z1aA:
32.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2z1a 5'-NUCLEOTIDASE

(Thermus
thermophilus) 		PF00149
(Metallophos)
PF02872
(5_nucleotid_C) 		5 GLY A 380
GLY A 381
PHE A 402
ASN A 479
GLY A 432
 THM  A6510 (-4.1A)
THM  A6510 (-3.6A)
THM  A6510 (-3.7A)
THM  A6510 ( 4.7A)
THM  A6510 (-3.2A)
 1.08A 3ztvA-2z1aA:
42.3		 3ztvA-2z1aA:
32.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z8z LIPASE

(Pseudomonas sp.
MIS38) 		PF00353
(HemolysinCabind) 		5 GLY A 539
GLY A 540
ASN A 562
GLY A 520
ASP A 525
 CA  A 626 ( 4.5A)
CA  A 626 (-4.2A)
CA  A 628 (-3.0A)
CA  A 626 ( 4.6A)
CA  A 624 ( 2.7A)
 1.10A 3ztvA-2z8zA:
undetectable		 3ztvA-2z8zA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3go7 RIBOKINASE RBSK

(Mycobacterium
tuberculosis) 		PF00294
(PfkB) 		5 ASN A  55
GLY A  51
GLY A  50
GLY A  53
ASP A 242
 RIB  A 305 (-3.2A)
RIB  A 305 (-3.1A)
RIB  A 305 ( 3.7A)
None
RIB  A 305 (-2.9A)
 1.04A 3ztvA-3go7A:
undetectable		 3ztvA-3go7A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gq9 PRENECK APPENDAGE
PROTEIN

(Bacillus virus
phi29) 		PF11962
(Peptidase_G2)
PF12708
(Pectate_lyase_3) 		5 ASN A 307
GLY A 330
PHE A 397
SER A 325
GLY A 331
 NA  A   1 (-4.4A)
None
None
None
None
 1.30A 3ztvA-3gq9A:
undetectable		 3ztvA-3gq9A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gtt SUPEROXIDE DISMUTASE
[CU-ZN]

(Mus musculus) 		PF00080
(Sod_Cu) 		5 GLY A  72
GLY A  73
SER A 134
GLY A 127
ASP A 125
 None
 1.29A 3ztvA-3gttA:
undetectable		 3ztvA-3gttA:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h3b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2

(Homo sapiens) 		PF01030
(Recep_L_domain) 		5 ASN A  37
GLY A  36
GLY A  60
GLY A   6
ASP A   8
 None
 0.96A 3ztvA-3h3bA:
undetectable		 3ztvA-3h3bA:
13.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h9n RIBOSOME MATURATION
FACTOR RIMM

(Haemophilus
influenzae) 		PF01782
(RimM)
PF05239
(PRC) 		5 GLY A 177
ASN A 114
GLY A 146
TYR A 118
ASP A 143
 SO4  A   1 (-3.3A)
None
None
None
None
 1.26A 3ztvA-3h9nA:
undetectable		 3ztvA-3h9nA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hpx 2-ISOPROPYLMALATE
SYNTHASE

(Mycobacterium
tuberculosis) 		PF00682
(HMGL-like) 		5 ASN A 321
GLY A 316
GLY A 320
GLY A  82
ASP A  81
 NI  A 701 (-2.7A)
None
None
None
NI  A 701 (-2.5A)
 1.15A 3ztvA-3hpxA:
undetectable		 3ztvA-3hpxA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ive NUCLEOTIDASE

(Escherichia
coli) 		PF00149
(Metallophos)
PF02872
(5_nucleotid_C) 		6 ASN A 370
GLY A 372
GLY A 373
PHE A 394
ASN A 396
ASP A 472
 CTN  A 603 (-3.2A)
CTN  A 603 (-3.2A)
CTN  A 603 (-3.3A)
CTN  A 603 (-3.5A)
CTN  A 603 (-3.0A)
CTN  A 603 (-2.7A)
 0.61A 3ztvA-3iveA:
33.3		 3ztvA-3iveA:
28.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l9y SUPEROXIDE DISMUTASE
[CU-ZN]

(Bombyx mori) 		PF00080
(Sod_Cu) 		5 GLY A  71
GLY A  72
SER A 134
GLY A 127
ASP A 125
 None
 1.31A 3ztvA-3l9yA:
undetectable		 3ztvA-3l9yA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n0t DIPEPTIDYL PEPTIDASE
2

(Homo sapiens) 		PF05577
(Peptidase_S28) 		5 GLY A 441
GLY A 440
SER A 186
GLY A 415
TYR A 274
 None
 1.27A 3ztvA-3n0tA:
undetectable		 3ztvA-3n0tA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n5f N-CARBAMOYL-L-AMINO
ACID HYDROLASE

(Geobacillus
stearothermophilus) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		5 ASN A  85
GLY A  24
GLY A  23
SER A  82
GLY A  86
 None
 1.03A 3ztvA-3n5fA:
undetectable		 3ztvA-3n5fA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3na6 SUCCINYLGLUTAMATE
DESUCCINYLASE/ASPART
OACYLASE

(Ruegeria sp.
TM1040) 		PF04952
(AstE_AspA) 		5 ASN A  57
PHE A 129
GLY A  55
TYR A 194
ASP A 142
 None
 1.27A 3ztvA-3na6A:
undetectable		 3ztvA-3na6A:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ooq AMIDOHYDROLASE

(Thermotoga
maritima) 		PF01979
(Amidohydro_1) 		5 ASN A  81
GLY A 120
ASN A 157
SER A  78
GLY A  80
 None
 1.06A 3ztvA-3ooqA:
1.4		 3ztvA-3ooqA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ops MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN

(Paenibacillus
sp. Y412MC10) 		PF13378
(MR_MLE_C) 		5 GLY A 174
GLY A 175
GLY A 183
TYR A 212
ASP A 187
 None
 1.10A 3ztvA-3opsA:
undetectable		 3ztvA-3opsA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q9t CHOLINE
DEHYDROGENASE AND
RELATED
FLAVOPROTEINS

(Aspergillus
oryzae) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		5 GLY A  16
GLY A  19
SER A  96
GLY A  92
TYR A 562
 FAY  A 600 (-3.2A)
None
None
None
None
 1.32A 3ztvA-3q9tA:
undetectable		 3ztvA-3q9tA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q9t CHOLINE
DEHYDROGENASE AND
RELATED
FLAVOPROTEINS

(Aspergillus
oryzae) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		5 GLY A  16
GLY A  19
SER A  96
GLY A  93
TYR A 562
 FAY  A 600 (-3.2A)
None
None
FAY  A 600 (-3.2A)
None
 0.89A 3ztvA-3q9tA:
undetectable		 3ztvA-3q9tA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qsl PUTATIVE EXPORTED
PROTEIN

(Bordetella
bronchiseptica) 		PF13379
(NMT1_2) 		5 GLY A  40
GLY A  41
SER A 148
GLY A  74
TYR A  46
 CIT  A 347 (-3.8A)
None
CIT  A 347 (-3.6A)
CIT  A 347 (-3.2A)
CIT  A 347 (-3.3A)
 1.11A 3ztvA-3qslA:
undetectable		 3ztvA-3qslA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rmj 2-ISOPROPYLMALATE
SYNTHASE

(Neisseria
meningitidis) 		PF00682
(HMGL-like) 		5 ASN A 240
GLY A 235
GLY A 239
GLY A  17
ASP A  16
 MN  A 365 (-2.6A)
None
None
None
MN  A 365 (-2.6A)
 1.13A 3ztvA-3rmjA:
2.0		 3ztvA-3rmjA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rpw ABC TRANSPORTER

(Rhodopseudomonas
palustris) 		PF13416
(SBP_bac_8) 		5 GLY A  39
GLY A  40
PHE A 297
GLY A  38
ASP A  36
 FMT  A 370 (-3.8A)
None
GOL  A 364 (-4.9A)
FMT  A 370 (-3.7A)
None
 1.22A 3ztvA-3rpwA:
undetectable		 3ztvA-3rpwA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ry7 RIBOKINASE

(Staphylococcus
aureus) 		PF00294
(PfkB) 		5 ASN A  45
GLY A  41
GLY A  40
GLY A  43
ASP A 254
 GOL  A 401 (-3.9A)
GOL  A 401 (-3.8A)
GOL  A 401 ( 3.7A)
None
None
 0.97A 3ztvA-3ry7A:
undetectable		 3ztvA-3ry7A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3suc PRENECK APPENDAGE
PROTEIN

(Bacillus virus
phi29) 		PF11962
(Peptidase_G2)
PF12708
(Pectate_lyase_3) 		5 ASN A 307
GLY A 330
PHE A 397
SER A 325
GLY A 331
 CA  A   1 ( 4.7A)
None
None
None
None
 1.32A 3ztvA-3sucA:
undetectable		 3ztvA-3sucA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t6s CERJ

(Streptomyces
tendae) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		5 ASN A 117
GLY A 325
GLY A 324
PHE A 323
GLY A 326
 None
 1.13A 3ztvA-3t6sA:
undetectable		 3ztvA-3t6sA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ujz METALLOPROTEASE STCE

(Escherichia
coli) 		PF10462
(Peptidase_M66) 		5 ASN A 451
GLY A 430
GLY A 431
SER A 428
GLY A 429
 None
 1.12A 3ztvA-3ujzA:
undetectable		 3ztvA-3ujzA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ujz METALLOPROTEASE STCE

(Escherichia
coli) 		PF10462
(Peptidase_M66) 		5 ASN A 451
GLY A 430
GLY A 432
SER A 428
GLY A 429
 None
 1.30A 3ztvA-3ujzA:
undetectable		 3ztvA-3ujzA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uqe 6-PHOSPHOFRUCTOKINAS
E ISOZYME 2

(Escherichia
coli) 		PF00294
(PfkB) 		5 ASN A  43
GLY A  38
SER A 137
GLY A  41
ASP A 256
 None
 1.05A 3ztvA-3uqeA:
undetectable		 3ztvA-3uqeA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uqe 6-PHOSPHOFRUCTOKINAS
E ISOZYME 2

(Escherichia
coli) 		PF00294
(PfkB) 		6 ASN A  43
GLY A  39
GLY A  38
SER A 137
GLY A  40
ASP A 256
 None
 1.11A 3ztvA-3uqeA:
undetectable		 3ztvA-3uqeA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wc3 ENDO-1,
4-BETA-GLUCANASE

(Eisenia fetida) 		PF00759
(Glyco_hydro_9) 		5 GLY A  70
GLY A  71
ASN A 434
SER A  56
GLY A  42
 None
 1.27A 3ztvA-3wc3A:
undetectable		 3ztvA-3wc3A:
21.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zu0 NAD NUCLEOTIDASE

(Haemophilus
influenzae) 		PF00149
(Metallophos)
PF02872
(5_nucleotid_C) 		9 ASN A 432
GLY A 434
GLY A 435
PHE A 456
ASN A 458
SER A 486
GLY A 488
TYR A 540
ASP A 546
 A12  A1598 (-3.5A)
A12  A1598 (-3.4A)
A12  A1598 (-3.6A)
A12  A1598 (-3.4A)
A12  A1598 (-3.1A)
A12  A1598 (-2.8A)
A12  A1598 (-3.4A)
A12  A1598 (-3.4A)
A12  A1598 (-2.7A)
 0.27A 3ztvA-3zu0A:
60.0		 3ztvA-3zu0A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zu0 NAD NUCLEOTIDASE

(Haemophilus
influenzae) 		PF00149
(Metallophos)
PF02872
(5_nucleotid_C) 		8 GLY A 434
GLY A 435
PHE A 456
ASN A 538
SER A 486
GLY A 488
TYR A 540
ASP A 546
 A12  A1598 (-3.4A)
A12  A1598 (-3.6A)
A12  A1598 (-3.4A)
A12  A1598 ( 4.4A)
A12  A1598 (-2.8A)
A12  A1598 (-3.4A)
A12  A1598 (-3.4A)
A12  A1598 (-2.7A)
 1.04A 3ztvA-3zu0A:
60.0		 3ztvA-3zu0A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ayj BOGT -
METAL-INDEPENDENT
GLYCOSYLTRANSFERASE

(Bacteroides
ovatus) 		PF03414
(Glyco_transf_6) 		5 GLY A 160
PHE A  92
SER A 114
GLY A 116
TYR A  90
 None
 1.24A 3ztvA-4ayjA:
undetectable		 3ztvA-4ayjA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d1y PUTATIVE PROTEASE I

(Bacteroides
thetaiotaomicron) 		PF01965
(DJ-1_PfpI) 		5 ASN A  14
GLY A  15
GLY A  17
ASN A 161
SER A  47
 None
None
None
RBF  A1176 (-4.2A)
None
 1.14A 3ztvA-4d1yA:
undetectable		 3ztvA-4d1yA:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dd5 ACETYL-COA
ACETYLTRANSFERASE

(Clostridioides
difficile) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		5 GLY A 387
GLY A 386
PHE A 157
ASN A 158
GLY A 287
 None
 1.09A 3ztvA-4dd5A:
undetectable		 3ztvA-4dd5A:
21.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4h1s 5'-NUCLEOTIDASE

(Homo sapiens) 		PF00149
(Metallophos)
PF02872
(5_nucleotid_C) 		5 ASN A 390
GLY A 391
GLY A 393
GLY A 447
ASP A 506
 None
 1.30A 3ztvA-4h1sA:
40.8		 3ztvA-4h1sA:
31.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4h1s 5'-NUCLEOTIDASE

(Homo sapiens) 		PF00149
(Metallophos)
PF02872
(5_nucleotid_C) 		6 ASN A 390
GLY A 392
GLY A 393
PHE A 417
GLY A 447
ASP A 506
 None
 0.44A 3ztvA-4h1sA:
40.8		 3ztvA-4h1sA:
31.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l8k PUTATIVE PEPTIDASE

(Parabacteroides
merdae) 		PF03572
(Peptidase_S41)
PF14684
(Tricorn_C1) 		5 ASN A 244
GLY A 265
GLY A 299
SER A 284
GLY A 266
 None
None
None
PO4  A 401 (-2.6A)
PO4  A 401 (-3.3A)
 1.21A 3ztvA-4l8kA:
undetectable		 3ztvA-4l8kA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m6r METHYLTHIORIBULOSE-1
-PHOSPHATE
DEHYDRATASE

(Homo sapiens) 		PF00596
(Aldolase_II) 		5 GLY A  46
GLY A  47
PHE A 101
GLY A  45
TYR A 198
 ZN  A 301 ( 4.9A)
None
None
None
None
 1.31A 3ztvA-4m6rA:
undetectable		 3ztvA-4m6rA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pve POLLEN ALLERGEN PHL
P 4.0202

(Phleum pratense) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		5 ASN A 158
GLY A 162
GLY A 163
PHE A 164
GLY A 161
 FAD  A 601 (-3.9A)
None
FAD  A 601 (-3.4A)
FAD  A 601 (-4.5A)
None
 1.25A 3ztvA-4pveA:
undetectable		 3ztvA-4pveA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rsl FRUCTOSYL PEPTIDE
OXIDASE

(Penicillium
terrenum) 		PF01266
(DAO) 		5 GLY A  17
GLY A  20
SER A  47
GLY A  16
ASP A  41
 FAD  A 502 (-3.1A)
None
FAD  A 502 (-2.4A)
FAD  A 502 (-4.2A)
FAD  A 502 (-3.0A)
 1.24A 3ztvA-4rslA:
undetectable		 3ztvA-4rslA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wj3 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A

(Pseudomonas
aeruginosa) 		PF01425
(Amidase) 		5 ASN A 131
GLY A 154
GLY A 155
ASN A  40
GLY A 150
 None
 1.05A 3ztvA-4wj3A:
undetectable		 3ztvA-4wj3A:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zdm GLUTAMATE RECEPTOR
KAINATE-LIKE PROTEIN

(Pleurobrachia
bachei) 		PF10613
(Lig_chan-Glu_bd) 		5 ASN A  77
GLY A  67
GLY A  68
GLY A  78
ASP A  63
 None
 1.06A 3ztvA-4zdmA:
undetectable		 3ztvA-4zdmA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zpd RNA-DIRECTED RNA
POLYMERASE

(Enterovirus B) 		PF00680
(RdRP_1) 		5 ASN A  65
GLY A   1
GLY A 285
ASN A 271
GLY A  64
 None
 1.29A 3ztvA-4zpdA:
undetectable		 3ztvA-4zpdA:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aee ALPHA-GLUCOSIDASE
YIHQ

(Escherichia
coli) 		PF01055
(Glyco_hydro_31) 		5 GLY A 507
ASN A 545
SER A 478
GLY A 482
ASP A 476
 None
 1.25A 3ztvA-5aeeA:
undetectable		 3ztvA-5aeeA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bv9 CELLULOSE
1,4-BETA-CELLOBIOSID
ASE

(Bacillus
pumilus) 		PF02011
(Glyco_hydro_48) 		5 GLY A 413
ASN A 502
SER A 685
GLY A 536
ASP A 534
 None
None
CBI  A 804 ( 4.7A)
None
CBI  A 804 (-3.0A)
 1.30A 3ztvA-5bv9A:
undetectable		 3ztvA-5bv9A:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c41 RIBOKINASE

(Homo sapiens) 		PF00294
(PfkB) 		5 ASN A  57
GLY A  53
GLY A  52
GLY A  55
ASP A 269
 None
None
None
None
NA  A 403 ( 4.7A)
 0.99A 3ztvA-5c41A:
undetectable		 3ztvA-5c41A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e9j MRNA CAP GUANINE-N7
METHYLTRANSFERASE,MR
NA CAP GUANINE-N7
METHYLTRANSFERASE

(Homo sapiens) 		PF03291
(Pox_MCEL) 		5 GLY A 209
GLY A 210
ASN A 177
SER A 232
GLY A 207
 None
None
None
SAH  A 501 ( 4.6A)
SAH  A 501 (-3.4A)
 1.30A 3ztvA-5e9jA:
undetectable		 3ztvA-5e9jA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fkr ENDO-1,4-BETA-GLUCAN
ASE/XYLOGLUCANASE,
PUTATIVE, GLY74A

(Cellvibrio
japonicus) 		no annotation 5 GLY A 153
GLY A 152
ASN A 123
GLY A 100
TYR A 121
 None
 1.07A 3ztvA-5fkrA:
undetectable		 3ztvA-5fkrA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5foz LARVICIDAL TOXIN
PROTEIN

(Lysinibacillus
sphaericus) 		PF05431
(Toxin_10) 		5 GLY B 308
ASN B 416
GLY B 312
TYR B 418
ASP B 310
 None
 1.21A 3ztvA-5fozB:
undetectable		 3ztvA-5fozB:
20.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5h7w VENOM
5'-NUCLEOTIDASE

(Naja atra) 		no annotation 5 ASN A 390
GLY A 391
GLY A 393
GLY A 448
ASP A 507
 None
 1.21A 3ztvA-5h7wA:
41.1		 3ztvA-5h7wA:
31.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5h7w VENOM
5'-NUCLEOTIDASE

(Naja atra) 		no annotation 6 ASN A 390
GLY A 392
GLY A 393
PHE A 418
GLY A 448
ASP A 507
 None
 0.72A 3ztvA-5h7wA:
41.1		 3ztvA-5h7wA:
31.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j44 SERINE PROTEASE SEPA
AUTOTRANSPORTER

(Shigella
flexneri) 		PF02395
(Peptidase_S6) 		5 GLY A 442
ASN A  92
GLY A 463
TYR A  89
ASP A 461
 None
 1.16A 3ztvA-5j44A:
undetectable		 3ztvA-5j44A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kp7 CURD

(Moorea
producens) 		PF01154
(HMG_CoA_synt_N)
PF08540
(HMG_CoA_synt_C) 		5 ASN A 312
GLY A 313
PHE A 315
SER A 305
GLY A 287
 None
 1.30A 3ztvA-5kp7A:
undetectable		 3ztvA-5kp7A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5me4 PROBABLE PHOSPHITE
TRANSPORT
SYSTEM-BINDING
PROTEIN HTXB

(Pseudomonas
stutzeri) 		no annotation 5 GLY A 131
PHE A 158
ASN A 161
GLY A 127
ASP A 125
 None
 1.09A 3ztvA-5me4A:
undetectable		 3ztvA-5me4A:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mif 'CARBOXYL ESTERASE 2

(Tuber
melanosporum) 		PF07859
(Abhydrolase_3) 		5 GLY A 118
GLY A 119
PHE A  53
SER A 127
GLY A 123
 None
 1.29A 3ztvA-5mifA:
undetectable		 3ztvA-5mifA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5njf METALLOPROTEASE TLDD

(Escherichia
coli) 		PF01523
(PmbA_TldD) 		5 GLY A 204
GLY A 205
PHE A 212
SER A 202
GLY A 203
 None
 0.99A 3ztvA-5njfA:
undetectable		 3ztvA-5njfA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5sga PROTEINASE A (SGPA)

(Streptomyces
griseus) 		PF00089
(Trypsin) 		5 GLY E 197
GLY E  45
ASN E  47
SER E 141
GLY E 140
 None
 1.19A 3ztvA-5sgaE:
undetectable		 3ztvA-5sgaE:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u2n NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE

(Homo sapiens) 		PF04095
(NAPRTase) 		5 GLY A 383
GLY A 385
ASN A 164
GLY A 194
ASP A 192
 None
 1.31A 3ztvA-5u2nA:
1.9		 3ztvA-5u2nA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vj1 MDCA

(Pseudomonas
aeruginosa) 		PF16957
(Mal_decarbox_Al) 		5 GLY A 381
PHE A 312
ASN A 292
SER A 108
GLY A 380
 None
CL  A 601 (-3.6A)
CL  A 601 ( 4.3A)
None
None
 1.24A 3ztvA-5vj1A:
undetectable		 3ztvA-5vj1A:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5whz ANTI-HIV CODV-FAB
HEAVY CHAIN
ANTI-HIV CODV-FAB
LIGHT CHAIN

(Homo sapiens) 		no annotation 5 GLY H 114
SER H 109
GLY H 110
TYR L 149
ASP H 106
 None
 1.12A 3ztvA-5whzH:
undetectable		 3ztvA-5whzH:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xlu GAMMA GLUTAMYL
TRANSPEPTIDASE

(Bacillus
licheniformis) 		no annotation 5 GLY A  89
GLY A  88
PHE A 236
SER A 108
GLY A  90
 GLY  A  89 ( 0.0A)
GLY  A  88 ( 0.0A)
PHE  A 236 ( 1.3A)
SER  A 108 ( 0.0A)
GLY  A  90 ( 0.0A)
 1.26A 3ztvA-5xluA:
undetectable		 3ztvA-5xluA:
7.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y31 DISINTEGRIN AND
METALLOPROTEINASE
DOMAIN-CONTAINING
PROTEIN 22

(Homo sapiens) 		no annotation 5 ASN A 377
GLY A 347
GLY A 346
PHE A 425
GLY A 354
 None
 1.26A 3ztvA-5y31A:
undetectable		 3ztvA-5y31A:
7.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c62 BIURET HYDROLASE

(Pseudomonas sp.
ADP) 		no annotation 5 GLY A 152
GLY A 153
ASN A  75
GLY A 149
ASP A 121
 None
 1.13A 3ztvA-6c62A:
undetectable		 3ztvA-6c62A:
10.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cfw MBH SUBUNIT
MONOVALENT CATION/H+
ANTIPORTER SUBUNIT B

(Pyrococcus
furiosus) 		no annotation 5 GLY F  37
GLY F  38
PHE E  65
GLY F  36
ASP D  64
 None
 1.17A 3ztvA-6cfwF:
undetectable		 3ztvA-6cfwF:
12.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f5o POLYMERASE BASIC
PROTEIN 2
RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza B
virus) 		no annotation 5 ASN C 648
GLY C 645
GLY C 644
SER B 291
GLY C 646
 None
 1.21A 3ztvA-6f5oC:
undetectable		 3ztvA-6f5oC:
10.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gbg OUTER MEMBRANE
PROTEIN

(Helicobacter
pylori) 		no annotation 5 ASN A 148
GLY A 133
GLY A 134
SER A 157
GLY A 104
 None
 0.97A 3ztvA-6gbgA:
undetectable		 3ztvA-6gbgA:
9.33