SIMILAR PATTERNS OF AMINO ACIDS FOR 3ZS3_A_ACTA1227

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pan GLYOXYLATE
CARBOLIGASE

(Escherichia
coli) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		4 THR A  62
ARG A  63
ASN A 216
ILE A  95
 None
None
FAD  A 701 (-3.9A)
None
 1.39A 3zs3A-2panA:
0.0		 3zs3A-2panA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3icq EXPORTIN-T

(Schizosaccharomyces
pombe) 		PF08389
(Xpo1) 		4 THR T 782
ARG T 786
ASN T 747
ILE T 749
 None
 1.01A 3zs3A-3icqT:
undetectable		 3zs3A-3icqT:
12.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pvz UDP-N-ACETYLGLUCOSAM
INE 4,6-DEHYDRATASE

(Aliivibrio
fischeri) 		PF02719
(Polysacc_synt_2) 		4 THR A 162
ARG A 196
ASN A 342
ILE A 253
 None
 1.44A 3zs3A-3pvzA:
0.0		 3zs3A-3pvzA:
19.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zs3 THAUMATIN-LIKE
PROTEIN

(Malus domestica) 		PF00314
(Thaumatin) 		4 THR A  55
ARG A  56
ASN A 137
ILE A 154
 ACT  A1227 (-3.1A)
ACT  A1227 (-3.9A)
ACT  A1227 ( 4.7A)
ACT  A1227 (-4.2A)
 0.01A 3zs3A-3zs3A:
43.1		 3zs3A-3zs3A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zs3 THAUMATIN-LIKE
PROTEIN

(Malus domestica) 		PF00314
(Thaumatin) 		4 THR A  69
ARG A  56
ASN A 137
ILE A 154
 ACT  A1227 ( 4.4A)
ACT  A1227 (-3.9A)
ACT  A1227 ( 4.7A)
ACT  A1227 (-4.2A)
 1.04A 3zs3A-3zs3A:
43.1		 3zs3A-3zs3A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4irt UNCHARACTERIZED
PROTEIN

(Bacteroides
ovatus) 		PF15892
(BNR_4) 		4 THR A 271
ARG A 333
ASN A 223
ILE A 268
 None
 1.41A 3zs3A-4irtA:
0.0		 3zs3A-4irtA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mul NEURAMINIDASE

(Bacteroides
thetaiotaomicron) 		PF15892
(BNR_4) 		4 THR A 271
ARG A 333
ASN A 223
ILE A 268
 None
 1.24A 3zs3A-5mulA:
0.0		 3zs3A-5mulA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mvh BACCELL_00856

(Bacteroides
cellulosilyticus) 		PF15892
(BNR_4) 		4 THR A 271
ARG A 333
ASN A 223
ILE A 268
 None
 1.39A 3zs3A-5mvhA:
0.0		 3zs3A-5mvhA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5txr 5-AMINOLEVULINATE
SYNTHASE,
MITOCHONDRIAL

(Saccharomyces
cerevisiae) 		no annotation 4 THR B 392
ARG B 391
ASN B 525
ILE B 388
 None
 1.32A 3zs3A-5txrB:
0.0		 3zs3A-5txrB:
undetectable