SIMILAR PATTERNS OF AMINO ACIDS FOR 3ZS3_A_ACTA1226

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zs3 THAUMATIN-LIKE
PROTEIN

(Malus domestica) 		PF00314
(Thaumatin) 		5 GLU A 190
TYR A 197
ASP A 202
ASN A 205
PHE A 208
 ACT  A1226 ( 3.9A)
ACT  A1226 ( 4.6A)
ACT  A1226 ( 3.6A)
ACT  A1226 ( 3.8A)
ACT  A1226 (-4.6A)
 0.00A 3zs3A-3zs3A:
43.1		 3zs3A-3zs3A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uu2 FERULIC ACID
DECARBOXYLASE

(Enterobacter
sp.) 		PF05870
(PA_decarbox) 		4 GLU A 149
ASP A  38
ASN A 111
PHE A 109
 None
 1.34A 3zs3A-4uu2A:
0.0		 3zs3A-4uu2A:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ymk ACYL-COA DESATURASE
1

(Mus musculus) 		PF00487
(FA_desaturase) 		4 GLU A 148
TYR A 214
ASP A 145
PHE A 142
 None
None
None
ST9  A 403 (-4.3A)
 1.24A 3zs3A-4ymkA:
undetectable		 3zs3A-4ymkA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zyo ACYL-COA DESATURASE

(Homo sapiens) 		no annotation 4 GLU A 152
TYR A 218
ASP A 149
PHE A 146
 None
None
None
ST9  A 403 (-4.4A)
 1.19A 3zs3A-4zyoA:
undetectable		 3zs3A-4zyoA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iry DESMOCOLLIN-1

(Homo sapiens) 		PF00028
(Cadherin) 		4 GLU A 402
TYR A 436
ASP A 438
ASN A 469
 CA  A 609 ( 2.1A)
None
CA  A 609 ( 2.7A)
None
 1.47A 3zs3A-5iryA:
0.0		 3zs3A-5iryA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jip CORTICAL-LYTIC
ENZYME

(Clostridium
perfringens) 		PF01183
(Glyco_hydro_25) 		4 GLU A 115
TYR A  73
ASP A 113
ASN A  20
 MES  A 401 ( 2.7A)
MES  A 401 (-3.2A)
MES  A 401 (-2.8A)
MES  A 401 (-3.8A)
 1.11A 3zs3A-5jipA:
0.0		 3zs3A-5jipA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kbw RIBOFLAVIN
TRANSPORTER RIBU

(Thermotoga
maritima) 		PF12822
(ECF_trnsprt) 		4 GLU A  40
ASP A 156
ASN A 149
PHE A 148
 None
None
RBF  A 201 (-1.8A)
RBF  A 201 (-4.9A)
 1.25A 3zs3A-5kbwA:
0.0		 3zs3A-5kbwA:
18.92