SIMILAR PATTERNS OF AMINO ACIDS FOR 3ZS3_A_ACTA1224

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qd1 FORMIMINOTRANSFERASE
-CYCLODEAMINASE

(Sus scrofa) 		PF02971
(FTCD)
PF07837
(FTCD_N) 		4 SER A  40
GLU A  13
THR A  47
TYR A  49
 None
 1.48A 3zs3A-1qd1A:
0.0		 3zs3A-1qd1A:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uj4 RIBOSE 5-PHOSPHATE
ISOMERASE

(Thermus
thermophilus) 		PF06026
(Rib_5-P_isom_A) 		4 SER A  59
GLU A 108
THR A  62
ASP A  86
 None
CL  A 301 (-3.1A)
None
None
 1.20A 3zs3A-1uj4A:
undetectable		 3zs3A-1uj4A:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xf1 C5A PEPTIDASE

(Streptococcus
pyogenes) 		PF00082
(Peptidase_S8)
PF02225
(PA)
PF06280
(fn3_5)
PF13585
(CHU_C) 		4 SER A 787
THR A 976
TYR A 978
ASP A 803
 None
 1.27A 3zs3A-1xf1A:
0.0		 3zs3A-1xf1A:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f8m RIBOSE 5-PHOSPHATE
ISOMERASE

(Plasmodium
falciparum) 		PF06026
(Rib_5-P_isom_A) 		4 SER A  56
GLU A 106
THR A  59
ASP A  84
 None
 1.23A 3zs3A-2f8mA:
0.0		 3zs3A-2f8mA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oae DIPEPTIDYL PEPTIDASE
4

(Rattus
norvegicus) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		4 SER A 413
GLU A 465
THR A 412
ASP A  63
 None
 1.42A 3zs3A-2oaeA:
0.0		 3zs3A-2oaeA:
13.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q4x SEED MATURATION
PROTEIN PM36 HOMOLOG

(Arabidopsis
thaliana) 		PF03070
(TENA_THI-4) 		4 SER A 146
GLU A 210
THR A  22
TYR A  18
 None
HMH  A1300 (-2.8A)
None
None
 1.35A 3zs3A-2q4xA:
undetectable		 3zs3A-2q4xA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wd5 STRUCTURAL
MAINTENANCE OF
CHROMOSOMES PROTEIN
1A
STRUCTURAL
MAINTENANCE OF
CHROMOSOMES PROTEIN
3

(Mus musculus;
Mus musculus) 		PF06470
(SMC_hinge)
PF06470
(SMC_hinge) 		4 SER A 653
GLU B 583
THR B 585
TYR B 559
 None
 1.15A 3zs3A-2wd5A:
0.0		 3zs3A-2wd5A:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bww PROTEIN OF UNKNOWN
FUNCTION
DUF692/COG3220

(Histophilus
somni) 		PF05114
(DUF692) 		4 SER A  92
GLU A 138
TYR A 201
ASP A 171
 None
FE  A 307 (-2.5A)
None
FE  A 308 ( 3.2A)
 1.49A 3zs3A-3bwwA:
undetectable		 3zs3A-3bwwA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d8u PURR TRANSCRIPTIONAL
REGULATOR

(Vibrio
parahaemolyticus) 		PF13377
(Peripla_BP_3) 		4 SER A  91
GLU A 304
THR A 308
ASP A 302
 None
 1.48A 3zs3A-3d8uA:
0.0		 3zs3A-3d8uA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eet PUTATIVE GNTR-FAMILY
TRANSCRIPTIONAL
REGULATOR

(Streptomyces
avermitilis) 		PF00392
(GntR)
PF07702
(UTRA) 		4 SER A 111
GLU A 153
THR A 135
TYR A 137
 None
 1.16A 3zs3A-3eetA:
undetectable		 3zs3A-3eetA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i9h BETA AND GAMMA
CRYSTALLIN

(Clostridium
beijerinckii) 		no annotation 4 SER A  18
THR A   5
TYR A   7
ASP A  68
 None
 1.16A 3zs3A-3i9hA:
undetectable		 3zs3A-3i9hA:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kfo NUCLEOPORIN NUP133

(Saccharomyces
cerevisiae) 		no annotation 4 SER A 993
GLU A 990
THR A 995
ASP A1001
 None
 1.47A 3zs3A-3kfoA:
undetectable		 3zs3A-3kfoA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ohg UNCHARACTERIZED
PROTEIN FROM DUF2233
FAMILY

(Bacteroides
ovatus) 		PF09992
(NAGPA) 		4 SER A 108
THR A 306
TYR A 134
ASP A 270
 None
None
None
EDO  A 414 ( 4.7A)
 1.29A 3zs3A-3ohgA:
undetectable		 3zs3A-3ohgA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pfo PUTATIVE
ACETYLORNITHINE
DEACETYLASE

(Rhodopseudomonas
palustris) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		4 SER A 179
GLU A 177
THR A 180
ASP A 378
 None
ZN  A 450 (-3.7A)
None
None
 1.33A 3zs3A-3pfoA:
undetectable		 3zs3A-3pfoA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t6p BACULOVIRAL IAP
REPEAT-CONTAINING
PROTEIN 2

(Homo sapiens) 		PF00619
(CARD)
PF00653
(BIR)
PF13920
(zf-C3HC4_3) 		4 SER A 415
GLU A 317
THR A 419
ASP A 320
 None
 1.39A 3zs3A-3t6pA:
undetectable		 3zs3A-3t6pA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vyl L-RIBULOSE
3-EPIMERASE

(Mesorhizobium
loti) 		PF01261
(AP_endonuc_2) 		4 SER A  64
GLU A 241
TYR A 204
ASP A 180
 None
MN  A1001 (-2.3A)
None
MN  A1001 (-3.1A)
 1.49A 3zs3A-3vylA:
undetectable		 3zs3A-3vylA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zgj 4-HYDROXYPHENYLPYRUV
IC ACID DIOXYGENASE

(Streptomyces
coelicolor) 		PF00903
(Glyoxalase)
PF14696
(Glyoxalase_5) 		4 SER A  59
THR A  72
TYR A  25
ASP A  94
 None
 1.31A 3zs3A-3zgjA:
undetectable		 3zs3A-3zgjA:
19.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zs3 THAUMATIN-LIKE
PROTEIN

(Malus domestica) 		PF00314
(Thaumatin) 		5 SER A  48
GLU A  92
THR A  94
TYR A 103
ASP A 105
 ACT  A1224 ( 3.7A)
ACT  A1224 (-3.9A)
ACT  A1224 (-3.8A)
ACT  A1224 (-4.3A)
ACT  A1224 (-4.2A)
 0.00A 3zs3A-3zs3A:
43.1		 3zs3A-3zs3A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fio METHENYLTETRAHYDROME
THANOPTERIN
CYCLOHYDROLASE

(Methanobrevibacter
ruminantium) 		PF02289
(MCH) 		4 SER A 111
GLU A 142
THR A 140
TYR A  52
 None
 1.34A 3zs3A-4fioA:
undetectable		 3zs3A-4fioA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gmk RIBOSE-5-PHOSPHATE
ISOMERASE A

(Lactobacillus
salivarius) 		PF06026
(Rib_5-P_isom_A) 		4 SER A  56
GLU A 106
THR A  59
ASP A  84
 None
PO4  A 301 (-3.1A)
None
PO4  A 301 ( 4.3A)
 1.21A 3zs3A-4gmkA:
undetectable		 3zs3A-4gmkA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ixl XYLANASE

(Bacillus sp.
(in: Bacteria)) 		PF00457
(Glyco_hydro_11) 		4 SER A 188
GLU A  38
THR A  40
TYR A  24
 None
 1.26A 3zs3A-4ixlA:
undetectable		 3zs3A-4ixlA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j0m SERINE/THREONINE-PRO
TEIN KINASE
BRI1-LIKE 1

(Arabidopsis
thaliana) 		PF08263
(LRRNT_2)
PF13516
(LRR_6)
PF13855
(LRR_8) 		4 SER A 234
THR A 209
TYR A 184
ASP A 181
 NAG  A 805 (-2.7A)
NAG  A 805 ( 4.4A)
None
NAG  A 811 (-3.9A)
 1.27A 3zs3A-4j0mA:
undetectable		 3zs3A-4j0mA:
15.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4leb AGGLUTININ-LIKE
PROTEIN 3

(Candida
albicans) 		PF11766
(Candida_ALS_N) 		4 SER A 274
THR A 202
TYR A 203
ASP A 205
 None
 1.31A 3zs3A-4lebA:
undetectable		 3zs3A-4lebA:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n4p ACYLNEURAMINATE
LYASE

(Mycoplasma
synoviae) 		PF00701
(DHDPS) 		4 SER A 210
GLU A 194
THR A 211
TYR A 244
 None
 1.48A 3zs3A-4n4pA:
undetectable		 3zs3A-4n4pA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nml RIBULOSE 5-PHOSPHATE
ISOMERASE

(Toxoplasma
gondii) 		PF06026
(Rib_5-P_isom_A) 		4 SER A  59
GLU A 111
THR A  62
ASP A  88
 None
CL  A 301 (-3.1A)
None
None
 1.19A 3zs3A-4nmlA:
undetectable		 3zs3A-4nmlA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o9r SMOOTHENED
HOMOLOG/SOLUBLE
CYTOCHROME B562
CHIMERIC PROTEIN

(Escherichia
coli;
Homo sapiens) 		PF01534
(Frizzled)
PF07361
(Cytochrom_B562) 		4 SER A 387
GLU A 518
TYR A 394
ASP A 473
 None
CY8  A1201 (-3.3A)
CY8  A1201 (-4.3A)
CY8  A1201 (-4.2A)
 1.32A 3zs3A-4o9rA:
undetectable		 3zs3A-4o9rA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rul DNA TOPOISOMERASE 1

(Escherichia
coli) 		PF01131
(Topoisom_bac)
PF01396
(zf-C4_Topoisom)
PF01751
(Toprim)
PF08272
(Topo_Zn_Ribbon) 		4 SER A 499
GLU A 115
THR A 496
ASP A 113
 None
 1.42A 3zs3A-4rulA:
undetectable		 3zs3A-4rulA:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u3j PROTEIN STU2

(Saccharomyces
cerevisiae) 		no annotation 4 SER C 493
GLU C 488
THR C 494
ASP C 447
 None
 1.39A 3zs3A-4u3jC:
undetectable		 3zs3A-4u3jC:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x84 RIBOSE-5-PHOSPHATE
ISOMERASE A

(Pseudomonas
aeruginosa) 		PF06026
(Rib_5-P_isom_A) 		4 SER A  57
GLU A 107
THR A  60
ASP A  85
 None
FLC  A 300 ( 4.1A)
None
None
 1.17A 3zs3A-4x84A:
undetectable		 3zs3A-4x84A:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y07 NEDD4-LIKE E3
UBIQUITIN-PROTEIN
LIGASE WWP2

(Homo sapiens) 		PF00632
(HECT) 		4 SER A 835
GLU A 865
THR A 837
ASP A 643
 None
 1.30A 3zs3A-4y07A:
undetectable		 3zs3A-4y07A:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z2a FURIN

(Homo sapiens) 		PF00082
(Peptidase_S8)
PF01483
(P_proprotein) 		4 SER A 318
GLU A 331
THR A 367
ASP A 258
 None
CA  A 604 (-2.2A)
None
CA  A 604 (-3.2A)
 1.47A 3zs3A-4z2aA:
undetectable		 3zs3A-4z2aA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5awf PROBABLE
ATP-DEPENDENT
TRANSPORTER SUFC

(Escherichia
coli) 		PF00005
(ABC_tran) 		4 SER C 174
GLU C 171
TYR C  86
ASP C 170
 None
 1.20A 3zs3A-5awfC:
undetectable		 3zs3A-5awfC:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c05 PUTATIVE
GAMMA-TERPINENE
SYNTHASE

(Thymus vulgaris) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		4 SER A 377
GLU A 374
THR A 378
ASP A 372
 SER  A 377 ( 0.0A)
GLU  A 374 ( 0.6A)
THR  A 378 ( 0.8A)
ASP  A 372 ( 0.6A)
 1.49A 3zs3A-5c05A:
undetectable		 3zs3A-5c05A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dji 3'-PHOSPHOADENOSINE
5'-PHOSPHATE
PHOSPHATASE

(Mycobacterium
tuberculosis) 		PF00459
(Inositol_P) 		4 SER A 100
GLU A  98
THR A 101
ASP A 106
 None
AMP  A 303 ( 4.1A)
None
None
 1.41A 3zs3A-5djiA:
undetectable		 3zs3A-5djiA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h4e BETA 1-3 GLUCANASE

(Clostridium
beijerinckii) 		no annotation 4 SER A 577
GLU A 358
THR A 370
TYR A 380
 None
 1.48A 3zs3A-5h4eA:
12.3		 3zs3A-5h4eA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jri PYRIDINE
NUCLEOTIDE-DISULFIDE
OXIDOREDUCTASE

(Synechocystis
sp. PCC 6803) 		no annotation 4 SER A 234
GLU A 229
TYR A 149
ASP A 230
 None
 1.25A 3zs3A-5jriA:
undetectable		 3zs3A-5jriA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o67 FAPF

(Pseudomonas sp.
UK4) 		no annotation 4 SER B 196
GLU B 176
THR B 178
ASP B 148
 None
LDA  B 502 ( 4.9A)
None
LDA  B 502 (-4.1A)
 1.09A 3zs3A-5o67B:
undetectable		 3zs3A-5o67B:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tr1 CHLORIDE CHANNEL
PROTEIN

(Bos taurus) 		PF00654
(Voltage_CLC) 		4 SER A 481
THR A 479
TYR A 520
ASP A 521
 None
 1.29A 3zs3A-5tr1A:
undetectable		 3zs3A-5tr1A:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x3t RIBONUCLEASE VAPC26

(Mycobacterium
tuberculosis) 		PF01850
(PIN) 		4 GLU B  56
THR B  49
TYR B  45
ASP B  44
 None
 1.17A 3zs3A-5x3tB:
undetectable		 3zs3A-5x3tB:
19.28