SIMILAR PATTERNS OF AMINO ACIDS FOR 3ZQT_A_TESA1000_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ax8 OBESITY PROTEIN

(Homo sapiens) 		PF02024
(Leptin) 		5 LEU A  86
LEU A  83
ASN A  82
LEU A  80
VAL A  18
 None
 1.25A 3zqtA-1ax8A:
undetectable		 3zqtA-1ax8A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1elv COMPLEMENT C1S
COMPONENT

(Homo sapiens) 		PF00084
(Sushi)
PF00089
(Trypsin) 		5 LEU A 456
LEU A 517
VAL A 657
MET A 661
THR A 651
 None
 1.35A 3zqtA-1elvA:
undetectable		 3zqtA-1elvA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gvh FLAVOHEMOPROTEIN

(Escherichia
coli) 		PF00042
(Globin)
PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6) 		5 LEU A 281
LEU A 278
LEU A 275
GLN A 271
THR A 263
 None
None
None
NA  A1400 (-4.2A)
None
 1.35A 3zqtA-1gvhA:
undetectable		 3zqtA-1gvhA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hlb HEMOGLOBIN (DEOXY)

(Molpadia
arenicola) 		PF00042
(Globin) 		5 LEU A  97
LEU A  96
VAL A  77
MET A  81
THR A 103
 None
None
HEM  A 158 ( 4.1A)
HEM  A 158 ( 4.8A)
HEM  A 158 (-3.2A)
 1.01A 3zqtA-1hlbA:
undetectable		 3zqtA-1hlbA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jhd SULFATE
ADENYLYLTRANSFERASE

(Sulfur-oxidizing
endosymbiont of
Riftia
pachyptila) 		PF01747
(ATP-sulfurylase)
PF14306
(PUA_2) 		5 LEU A 230
LEU A 229
GLN A 199
VAL A 226
ARG A 284
 None
None
BR  A2008 (-4.0A)
None
None
 1.40A 3zqtA-1jhdA:
undetectable		 3zqtA-1jhdA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lw7 TRANSCRIPTIONAL
REGULATOR NADR

(Haemophilus
influenzae) 		PF01467
(CTP_transf_like)
PF13521
(AAA_28) 		5 LEU A 339
LEU A 367
LEU A 370
GLN A 311
THR A 337
 None
 1.28A 3zqtA-1lw7A:
undetectable		 3zqtA-1lw7A:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1miv TRNA CCA-ADDING
ENZYME

(Geobacillus
stearothermophilus) 		PF01743
(PolyA_pol)
PF12627
(PolyA_pol_RNAbd)
PF13735
(tRNA_NucTran2_2) 		5 LEU A 234
LEU A 215
ASN A 221
LEU A 220
MET A 195
 None
 1.15A 3zqtA-1mivA:
undetectable		 3zqtA-1mivA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1puj CONSERVED
HYPOTHETICAL PROTEIN
YLQF

(Bacillus
subtilis) 		PF01926
(MMR_HSR1) 		5 LEU A  30
LEU A  56
LEU A  83
GLN A  95
VAL A  97
 None
 1.25A 3zqtA-1pujA:
undetectable		 3zqtA-1pujA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tqh CARBOXYLESTERASE
PRECURSOR

(Geobacillus
stearothermophilus) 		PF12146
(Hydrolase_4) 		5 LEU A  21
LEU A  22
MET A 115
VAL A 113
THR A 226
 None
 1.20A 3zqtA-1tqhA:
undetectable		 3zqtA-1tqhA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vz8 ORNITHINE
ACETYL-TRANSFERASE

(Streptomyces
clavuligerus) 		PF01960
(ArgJ) 		5 LEU A 175
LEU A 182
LEU A 183
VAL A  43
THR A 218
 None
 1.31A 3zqtA-1vz8A:
undetectable		 3zqtA-1vz8A:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xb7 STEROID HORMONE
RECEPTOR ERR1

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 LEU A 324
LEU A 327
MET A 362
VAL A 366
ARG A 372
 None
 0.50A 3zqtA-1xb7A:
26.4		 3zqtA-1xb7A:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xec DECORIN

(Bos taurus) 		PF01462
(LRRNT)
PF13855
(LRR_8) 		5 LEU A 252
LEU A 270
ASN A 273
LEU A 300
VAL A 267
 None
 1.42A 3zqtA-1xecA:
undetectable		 3zqtA-1xecA:
24.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y2f CELL DIVISION
PROTEIN ZIPA

(Escherichia
coli) 		PF04354
(ZipA_C) 		5 LEU A  23
ASN A  24
LEU A  28
VAL A  65
MET A  64
 None
 1.33A 3zqtA-1y2fA:
undetectable		 3zqtA-1y2fA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aja ANKYRIN REPEAT
FAMILY PROTEIN

(Legionella
pneumophila) 		no annotation 5 LEU A 176
LEU A 179
ASN A 180
LEU A 182
MET A 193
 None
 1.37A 3zqtA-2ajaA:
undetectable		 3zqtA-2ajaA:
21.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ax9 ANDROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		10 LEU A 701
LEU A 704
ASN A 705
LEU A 707
GLN A 711
MET A 745
VAL A 746
MET A 749
ARG A 752
MET A 895
 None
BHM  A   1 (-4.0A)
BHM  A   1 (-3.6A)
BHM  A   1 ( 4.2A)
BHM  A   1 (-2.2A)
BHM  A   1 (-3.9A)
BHM  A   1 (-3.6A)
BHM  A   1 (-4.3A)
BHM  A   1 (-3.8A)
None
 0.66A 3zqtA-2ax9A:
40.4		 3zqtA-2ax9A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ax9 ANDROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		11 LEU A 701
LEU A 704
ASN A 705
LEU A 707
MET A 742
MET A 745
VAL A 746
MET A 749
ARG A 752
THR A 877
MET A 895
 None
BHM  A   1 (-4.0A)
BHM  A   1 (-3.6A)
BHM  A   1 ( 4.2A)
BHM  A   1 ( 4.0A)
BHM  A   1 (-3.9A)
BHM  A   1 (-3.6A)
BHM  A   1 (-4.3A)
BHM  A   1 (-3.8A)
BHM  A   1 (-3.0A)
None
 0.52A 3zqtA-2ax9A:
40.4		 3zqtA-2ax9A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dhy CUE
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF02845
(CUE) 		5 LEU A  56
ASN A  59
GLN A  54
VAL A  48
MET A  32
 None
 1.29A 3zqtA-2dhyA:
undetectable		 3zqtA-2dhyA:
13.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j4b TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT
72/90-100 KDA

(Encephalitozoon
cuniculi) 		PF04494
(TFIID_NTD2) 		5 LEU A 134
LEU A 137
ASN A 138
LEU A 141
VAL A 145
 None
 1.09A 3zqtA-2j4bA:
undetectable		 3zqtA-2j4bA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j4b TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT
72/90-100 KDA

(Encephalitozoon
cuniculi) 		PF04494
(TFIID_NTD2) 		5 LEU A 134
LEU A 137
LEU A 141
VAL A 145
MET A 113
 None
 1.17A 3zqtA-2j4bA:
undetectable		 3zqtA-2j4bA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oez UPF0289 PROTEIN
VP2528

(Vibrio
parahaemolyticus) 		PF07072
(ZapD) 		5 LEU A 202
LEU A 242
GLN A 183
VAL A 238
THR A   3
 None
 1.12A 3zqtA-2oezA:
undetectable		 3zqtA-2oezA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p4w TRANSCRIPTIONAL
REGULATORY PROTEIN
ARSR FAMILY

(Pyrococcus
furiosus) 		PF01022
(HTH_5) 		5 LEU A  52
LEU A  49
GLN A  42
ARG A  71
THR A  16
 None
 1.41A 3zqtA-2p4wA:
undetectable		 3zqtA-2p4wA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pl3 PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX10

(Homo sapiens) 		PF00270
(DEAD) 		5 LEU A 251
LEU A 263
LEU A 266
VAL A 239
THR A 249
 None
EOH  A 403 (-3.9A)
EOH  A 403 (-4.0A)
None
None
 1.39A 3zqtA-2pl3A:
undetectable		 3zqtA-2pl3A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pzh HYPOTHETICAL PROTEIN
HP_0496

(Helicobacter
pylori) 		PF03061
(4HBT) 		5 LEU A  75
LEU A 130
ASN A 131
LEU A 129
GLN A  36
 None
 1.39A 3zqtA-2pzhA:
undetectable		 3zqtA-2pzhA:
18.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2q3y ANCESTRAL CORTICIOD
RECEPTOR

(unidentified) 		PF00104
(Hormone_recep) 		8 LEU A  29
LEU A  32
ASN A  33
LEU A  35
GLN A  39
MET A  70
MET A  73
ARG A  80
 1CA  A 247 ( 3.6A)
1CA  A 247 (-4.0A)
1CA  A 247 (-2.9A)
1CA  A 247 ( 4.4A)
1CA  A 247 (-3.1A)
1CA  A 247 ( 3.8A)
1CA  A 247 (-3.6A)
1CA  A 247 (-3.8A)
 0.70A 3zqtA-2q3yA:
37.4		 3zqtA-2q3yA:
58.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q6z UROPORPHYRINOGEN
DECARBOXYLASE

(Homo sapiens) 		PF01208
(URO-D) 		5 LEU A 118
LEU A 121
MET A 162
MET A 165
VAL A 166
 None
 1.20A 3zqtA-2q6zA:
undetectable		 3zqtA-2q6zA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qjx PROTEIN BIM1

(Saccharomyces
cerevisiae) 		no annotation 5 LEU A  13
LEU A  16
ASN A  17
LEU A  20
GLN A  38
 None
 1.33A 3zqtA-2qjxA:
undetectable		 3zqtA-2qjxA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rad SUCCINOGLYCAN
BIOSYNTHESIS PROTEIN

(Bacillus cereus) 		PF05139
(Erythro_esteras) 		5 LEU A 430
LEU A 423
GLN A 401
MET A 315
VAL A 419
 None
 1.28A 3zqtA-2radA:
undetectable		 3zqtA-2radA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wzg GLUCOSYLTRANSFERASE

(Legionella
pneumophila) 		PF16849
(Glyco_transf_88) 		5 LEU A 403
LEU A 406
MET A 427
VAL A 426
MET A 429
 None
 1.23A 3zqtA-2wzgA:
undetectable		 3zqtA-2wzgA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xa7 ADAPTOR-RELATED
PROTEIN COMPLEX 2,
ALPHA 2 SUBUNIT

(Rattus
norvegicus) 		PF01602
(Adaptin_N) 		5 LEU A 541
LEU A 526
LEU A 525
GLN A 488
VAL A 483
 None
 1.33A 3zqtA-2xa7A:
undetectable		 3zqtA-2xa7A:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yn9 POTASSIUM-TRANSPORTI
NG ATPASE ALPHA
CHAIN 1

(Sus scrofa) 		PF00122
(E1-E2_ATPase)
PF00689
(Cation_ATPase_C)
PF00690
(Cation_ATPase_N)
PF09040
(H-K_ATPase_N)
PF13246
(Cation_ATPase) 		5 LEU A 759
ASN A 763
LEU A 760
VAL A 367
THR A 769
 None
 1.26A 3zqtA-2yn9A:
undetectable		 3zqtA-2yn9A:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z1a 5'-NUCLEOTIDASE

(Thermus
thermophilus) 		PF00149
(Metallophos)
PF02872
(5_nucleotid_C) 		5 LEU A 319
LEU A 320
MET A 330
MET A 327
VAL A 326
 None
 1.41A 3zqtA-2z1aA:
undetectable		 3zqtA-2z1aA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z65 TOLL-LIKE RECEPTOR
4, VARIABLE
LYMPHOCYTE RECEPTOR
B

(Eptatretus
burgeri;
Homo sapiens) 		PF11921
(DUF3439)
PF13306
(LRR_5)
PF13855
(LRR_8) 		5 LEU A 155
LEU A 180
LEU A 208
MET A 201
VAL A 197
 None
 1.26A 3zqtA-2z65A:
undetectable		 3zqtA-2z65A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3agr NUCLEOSIDE
TRIPHOSPHATE
HYDROLASE

(Neospora
caninum) 		PF01150
(GDA1_CD39) 		5 LEU A 537
LEU A 541
LEU A 542
VAL A 464
MET A 463
 None
 1.35A 3zqtA-3agrA:
undetectable		 3zqtA-3agrA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bac DNA LIGASE

(Haemophilus
influenzae) 		PF01653
(DNA_ligase_aden) 		5 LEU A 158
LEU A 131
GLN A 133
VAL A 122
THR A 152
 None
 1.36A 3zqtA-3bacA:
undetectable		 3zqtA-3bacA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c2b TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY

(Agrobacterium
fabrum) 		PF00440
(TetR_N) 		5 LEU A 110
ASN A 111
LEU A 113
GLN A 117
ARG A  57
 None
 1.26A 3zqtA-3c2bA:
undetectable		 3zqtA-3c2bA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c30 AUTOINDUCER 2 SENSOR
KINASE/PHOSPHATASE
LUXQ

(Vibrio cholerae) 		PF09308
(LuxQ-periplasm) 		5 LEU A 198
LEU A 192
ASN A 195
LEU A 220
VAL A 156
 None
 1.34A 3zqtA-3c30A:
undetectable		 3zqtA-3c30A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ciy TOLL-LIKE RECEPTOR 3

(Mus musculus) 		PF00560
(LRR_1)
PF13855
(LRR_8) 		5 LEU A 106
ASN A 109
LEU A 130
VAL A 103
THR A  59
 None
 1.40A 3zqtA-3ciyA:
undetectable		 3zqtA-3ciyA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ciy TOLL-LIKE RECEPTOR 3

(Mus musculus) 		PF00560
(LRR_1)
PF13855
(LRR_8) 		5 LEU A 535
LEU A 567
LEU A 588
GLN A 609
VAL A 581
 None
 1.42A 3zqtA-3ciyA:
undetectable		 3zqtA-3ciyA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h35 UNCHARACTERIZED
PROTEIN ABO_0056

(Alcanivorax
borkumensis) 		no annotation 5 LEU A 111
LEU A 116
LEU A 165
GLN A 168
VAL A  45
 None
 1.40A 3zqtA-3h35A:
undetectable		 3zqtA-3h35A:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hjh TRANSCRIPTION-REPAIR
-COUPLING FACTOR

(Escherichia
coli) 		no annotation 5 LEU A 339
LEU A  22
GLN A 356
VAL A 438
THR A  29
 None
 1.33A 3zqtA-3hjhA:
undetectable		 3zqtA-3hjhA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k70 EXODEOXYRIBONUCLEASE
V BETA CHAIN

(Escherichia
coli) 		PF00580
(UvrD-helicase)
PF12705
(PDDEXK_1)
PF13361
(UvrD_C) 		5 LEU B 557
LEU B 754
LEU B 815
MET B 453
VAL B 457
 None
 1.35A 3zqtA-3k70B:
undetectable		 3zqtA-3k70B:
11.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kba PROGESTERONE
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 LEU A 714
LEU A 718
LEU A 721
GLN A 725
MET A 759
ARG A 766
 None
WOW  A   1 (-4.2A)
WOW  A   1 ( 4.3A)
WOW  A   1 ( 4.1A)
WOW  A   1 (-3.7A)
WOW  A   1 (-3.8A)
 1.31A 3zqtA-3kbaA:
35.4		 3zqtA-3kbaA:
53.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kba PROGESTERONE
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		9 LEU A 715
LEU A 718
ASN A 719
LEU A 721
GLN A 725
MET A 756
MET A 759
VAL A 760
ARG A 766
 WOW  A   1 (-3.9A)
WOW  A   1 (-4.2A)
WOW  A   1 (-3.3A)
WOW  A   1 ( 4.3A)
WOW  A   1 ( 4.1A)
WOW  A   1 ( 4.1A)
WOW  A   1 (-3.7A)
WOW  A   1 (-4.1A)
WOW  A   1 (-3.8A)
 0.64A 3zqtA-3kbaA:
35.4		 3zqtA-3kbaA:
53.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kba PROGESTERONE
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		7 LEU A 715
LEU A 718
ASN A 719
LEU A 721
MET A 756
MET A 759
MET A 909
 WOW  A   1 (-3.9A)
WOW  A   1 (-4.2A)
WOW  A   1 (-3.3A)
WOW  A   1 ( 4.3A)
WOW  A   1 ( 4.1A)
WOW  A   1 (-3.7A)
None
 1.07A 3zqtA-3kbaA:
35.4		 3zqtA-3kbaA:
53.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kxw SAFRAMYCIN MX1
SYNTHETASE B

(Legionella
pneumophila) 		PF00501
(AMP-binding) 		5 LEU A 332
LEU A 333
ASN A 193
MET A 203
THR A 227
 1ZZ  A 589 (-4.6A)
1ZZ  A 589 ( 4.2A)
None
None
None
 1.41A 3zqtA-3kxwA:
undetectable		 3zqtA-3kxwA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qz1 STEROID
21-HYDROXYLASE

(Bos taurus) 		PF00067
(p450) 		5 LEU A  49
ASN A 386
LEU A  72
VAL A 382
MET A 381
 None
 1.09A 3zqtA-3qz1A:
2.3		 3zqtA-3qz1A:
19.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1

(synthetic
construct) 		PF00104
(Hormone_recep) 		7 LEU A  29
LEU A  32
ASN A  33
LEU A  35
MET A  70
MET A  73
ARG A  80
 1CA  A 249 ( 3.8A)
1CA  A 249 (-3.9A)
1CA  A 249 (-3.0A)
1CA  A 249 ( 4.4A)
1CA  A 249 ( 3.8A)
1CA  A 249 (-3.9A)
1CA  A 249 (-3.5A)
 0.58A 3zqtA-3ry9A:
36.8		 3zqtA-3ry9A:
53.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1

(synthetic
construct) 		PF00104
(Hormone_recep) 		7 LEU A  29
LEU A  32
LEU A  35
GLN A  39
MET A  70
MET A  73
ARG A  80
 1CA  A 249 ( 3.8A)
1CA  A 249 (-3.9A)
1CA  A 249 ( 4.4A)
1CA  A 249 (-3.0A)
1CA  A 249 ( 3.8A)
1CA  A 249 (-3.9A)
1CA  A 249 (-3.5A)
 0.70A 3zqtA-3ry9A:
36.8		 3zqtA-3ry9A:
53.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sf6 GLUTARYL-COA
DEHYDROGENASE

(Mycolicibacterium
smegmatis) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		5 LEU A  67
LEU A  70
VAL A  41
ARG A  43
MET A  75
 None
 1.28A 3zqtA-3sf6A:
undetectable		 3zqtA-3sf6A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3shq UBLCP1

(Drosophila
melanogaster) 		PF00240
(ubiquitin)
PF03031
(NIF) 		5 LEU A 293
LEU A 143
LEU A 142
MET A 211
VAL A 210
 None
 1.24A 3zqtA-3shqA:
undetectable		 3zqtA-3shqA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ty2 5'-NUCLEOTIDASE SURE

(Coxiella
burnetii) 		PF01975
(SurE) 		5 LEU A  16
LEU A  34
LEU A  37
GLN A 155
VAL A 149
 None
 1.27A 3zqtA-3ty2A:
undetectable		 3zqtA-3ty2A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u37 ACETYL-XYLAN
ESTERASE EST2A

(Butyrivibrio
proteoclasticus) 		PF13472
(Lipase_GDSL_2) 		5 LEU A 242
ASN A 241
MET A 163
THR A 244
MET A 308
 None
None
None
ACY  A 401 ( 4.5A)
None
 1.39A 3zqtA-3u37A:
undetectable		 3zqtA-3u37A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zny CTX-M-12A ENZYME

(Klebsiella
pneumoniae) 		PF13354
(Beta-lactamase2) 		5 LEU A 199
LEU A  81
GLN A 206
VAL A 208
MET A 211
 None
 1.33A 3zqtA-3znyA:
undetectable		 3zqtA-3znyA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4avy PROBABLE SHORT-CHAIN
DEHYDROGENASE

(Pseudomonas
aeruginosa) 		PF13561
(adh_short_C2) 		5 LEU A 121
LEU A  78
LEU A  75
VAL A  37
ARG A  56
 None
 1.40A 3zqtA-4avyA:
undetectable		 3zqtA-4avyA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b8s ADP-DEPENDENT
GLUCOKINASE

(Thermococcus
litoralis) 		PF04587
(ADP_PFK_GK) 		5 LEU A 266
LEU A 269
ASN A 270
VAL A  33
THR A 300
 None
None
None
None
GOL  A1469 (-4.5A)
 0.94A 3zqtA-4b8sA:
undetectable		 3zqtA-4b8sA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f6o METACASPASE-1

(Saccharomyces
cerevisiae) 		PF00656
(Peptidase_C14) 		5 LEU A 418
LEU A 359
LEU A 272
MET A 389
MET A 432
 None
 1.30A 3zqtA-4f6oA:
undetectable		 3zqtA-4f6oA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f6o METACASPASE-1

(Saccharomyces
cerevisiae) 		PF00656
(Peptidase_C14) 		5 LEU A 418
LEU A 359
LEU A 272
VAL A 388
MET A 432
 None
 1.40A 3zqtA-4f6oA:
undetectable		 3zqtA-4f6oA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ilr CRISPR-ASSOCIATED
ENDORIBONUCLEASE
CAS6 2

(Sulfolobus
solfataricus) 		PF10040
(CRISPR_Cas6) 		5 LEU A 125
LEU A 259
ASN A 256
LEU A 255
VAL A 139
 None
 1.40A 3zqtA-4ilrA:
undetectable		 3zqtA-4ilrA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iw7 8-AMINO-7-OXONONANOA
TE SYNTHASE

(Francisella
tularensis) 		PF00155
(Aminotran_1_2) 		5 LEU A  40
LEU A  38
ASN A 273
LEU A 277
GLN A 278
 None
 1.33A 3zqtA-4iw7A:
undetectable		 3zqtA-4iw7A:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j1y COMPLEMENT C1S
SUBCOMPONENT

(Homo sapiens) 		PF00084
(Sushi)
PF00089
(Trypsin) 		5 LEU A 471
LEU A 532
VAL A 672
MET A 676
THR A 666
 None
 1.42A 3zqtA-4j1yA:
undetectable		 3zqtA-4j1yA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l7w HD DOMAIN-CONTAINING
PROTEIN 2

(Homo sapiens) 		PF13023
(HD_3) 		5 LEU A 117
LEU A 113
LEU A 112
GLN A  19
VAL A  24
 None
 1.32A 3zqtA-4l7wA:
undetectable		 3zqtA-4l7wA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l9c F-BOX ONLY PROTEIN 7

(Homo sapiens) 		PF11566
(PI31_Prot_N) 		5 LEU A 301
LEU A 304
LEU A 307
GLN A 311
VAL A 313
 None
 1.29A 3zqtA-4l9cA:
undetectable		 3zqtA-4l9cA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mlc EXTRACELLULAR
LIGAND-BINDING
RECEPTOR

(Desulfitobacterium
hafniense) 		PF13458
(Peripla_BP_6) 		5 LEU A 212
LEU A 224
MET A 142
VAL A 143
MET A 195
 None
 1.40A 3zqtA-4mlcA:
undetectable		 3zqtA-4mlcA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mlc EXTRACELLULAR
LIGAND-BINDING
RECEPTOR

(Desulfitobacterium
hafniense) 		PF13458
(Peripla_BP_6) 		5 LEU A 249
LEU A 224
MET A 142
VAL A 143
MET A 195
 None
 1.41A 3zqtA-4mlcA:
undetectable		 3zqtA-4mlcA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n1y ESTROGEN RECEPTOR

(Crassostrea
gigas) 		PF00104
(Hormone_recep) 		5 LEU A 280
LEU A 283
LEU A 286
MET A 321
ARG A 331
 None
 0.54A 3zqtA-4n1yA:
28.7		 3zqtA-4n1yA:
28.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nzp ARGININOSUCCINATE
SYNTHASE

(Campylobacter
jejuni) 		PF00764
(Arginosuc_synth) 		6 LEU A 247
LEU A 250
ASN A 251
LEU A 253
VAL A 354
THR A 280
 None
 1.33A 3zqtA-4nzpA:
undetectable		 3zqtA-4nzpA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o3s DNA POLYMERASE ETA

(Homo sapiens) 		PF00817
(IMS)
PF11799
(IMS_C) 		5 LEU A 171
LEU A 142
LEU A 141
VAL A 197
ARG A 128
 None
 1.19A 3zqtA-4o3sA:
undetectable		 3zqtA-4o3sA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ojz PUTATIVE ALGINATE
LYASE

(Saccharophagus
degradans) 		PF05426
(Alginate_lyase)
PF07940
(Hepar_II_III) 		5 LEU A 625
LEU A 581
LEU A 572
VAL A 468
ARG A 643
 None
 1.29A 3zqtA-4ojzA:
undetectable		 3zqtA-4ojzA:
16.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p6w GLUCOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 LEU A 563
ASN A 564
LEU A 566
MET A 601
MET A 604
ARG A 611
 MOF  A 801 (-3.9A)
MOF  A 801 (-3.0A)
MOF  A 801 ( 4.6A)
MOF  A 801 (-3.7A)
None
MOF  A 801 (-4.2A)
 0.91A 3zqtA-4p6wA:
33.4		 3zqtA-4p6wA:
49.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p6w GLUCOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 LEU A 566
GLN A 570
MET A 601
MET A 604
ARG A 611
 MOF  A 801 ( 4.6A)
MOF  A 801 (-2.9A)
MOF  A 801 (-3.7A)
None
MOF  A 801 (-4.2A)
 1.01A 3zqtA-4p6wA:
33.4		 3zqtA-4p6wA:
49.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qj4 1-PHOSPHATIDYLINOSIT
OL 4,5-BISPHOSPHATE
PHOSPHODIESTERASE
BETA-3

(Homo sapiens) 		PF00168
(C2)
PF00387
(PI-PLC-Y)
PF00388
(PI-PLC-X)
PF09279
(EF-hand_like) 		5 LEU B 354
LEU B 355
GLN B 352
VAL B 347
ARG B  73
 None
 1.38A 3zqtA-4qj4B:
undetectable		 3zqtA-4qj4B:
14.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qmk TYPE III SECRETION
SYSTEM EFFECTOR
PROTEIN EXOU

(Pseudomonas
fluorescens) 		PF01734
(Patatin) 		5 LEU A 585
ASN A 582
GLN A 587
ARG A 591
THR A 628
 None
 1.35A 3zqtA-4qmkA:
undetectable		 3zqtA-4qmkA:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tx2 NON-RIBOSOMAL
PEPTIDE SYNTHETASE

(Actinoplanes
teichomyceticus) 		PF00668
(Condensation) 		5 LEU B 248
LEU B 262
GLN B 264
MET B 269
VAL B 321
 None
 1.37A 3zqtA-4tx2B:
undetectable		 3zqtA-4tx2B:
20.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4udb MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 LEU A 766
LEU A 769
ASN A 770
LEU A 772
MET A 807
ARG A 817
 CV7  A1987 (-3.6A)
CV7  A1987 (-4.1A)
CV7  A1987 (-3.1A)
CV7  A1987 ( 4.5A)
CV7  A1987 ( 3.9A)
CV7  A1987 (-3.7A)
 0.73A 3zqtA-4udbA:
34.0		 3zqtA-4udbA:
49.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4udb MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 LEU A 766
LEU A 772
GLN A 776
MET A 807
ARG A 817
 CV7  A1987 (-3.6A)
CV7  A1987 ( 4.5A)
CV7  A1987 (-3.0A)
CV7  A1987 ( 3.9A)
CV7  A1987 (-3.7A)
 0.88A 3zqtA-4udbA:
34.0		 3zqtA-4udbA:
49.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4usf STE20-LIKE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A 140
LEU A 143
ASN A 144
LEU A 146
THR A 282
 None
 1.25A 3zqtA-4usfA:
undetectable		 3zqtA-4usfA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xdt FAD:PROTEIN FMN
TRANSFERASE

(Treponema
pallidum) 		PF02424
(ApbE) 		5 LEU A  61
LEU A  64
ASN A  65
GLN A 150
ARG A 138
 None
 1.41A 3zqtA-4xdtA:
undetectable		 3zqtA-4xdtA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE

(Eimeria tenella) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		5 LEU A 321
LEU A 478
LEU A 479
GLN A 476
THR A 313
 None
 1.39A 3zqtA-4ysjA:
undetectable		 3zqtA-4ysjA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b1q U14 PROTEIN

(Human
betaherpesvirus
6B) 		PF04637
(Herpes_pp85) 		5 LEU A 359
LEU A 358
ASN A 355
LEU A 354
VAL A 344
 None
 1.39A 3zqtA-5b1qA:
undetectable		 3zqtA-5b1qA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cqs ELONGATOR COMPLEX
PROTEIN 1

(Saccharomyces
cerevisiae) 		PF04762
(IKI3) 		5 LEU A 958
LEU A 955
LEU A 952
VAL A 921
MET A 946
 None
 1.17A 3zqtA-5cqsA:
undetectable		 3zqtA-5cqsA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ctm BETA-LACTAMASE

(Bacillus
pumilus) 		PF00905
(Transpeptidase) 		5 LEU A 109
MET A 157
MET A 146
THR A 114
MET A 166
 None
None
KCX  A 104 ( 4.6A)
None
None
 1.14A 3zqtA-5ctmA:
undetectable		 3zqtA-5ctmA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dj4 SESTRIN-2

(Homo sapiens) 		PF04636
(PA26) 		5 LEU A 421
LEU A 417
GLN A 415
MET A 265
VAL A 388
 None
 1.20A 3zqtA-5dj4A:
undetectable		 3zqtA-5dj4A:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e4v NUCLEOPROTEIN,PHOSPH
OPROTEIN

(Measles
morbillivirus) 		PF00973
(Paramyxo_ncap)
PF13825
(Paramyxo_PNT) 		5 LEU A 277
LEU A 280
LEU A 283
MET A 294
VAL A 295
 None
 0.86A 3zqtA-5e4vA:
undetectable		 3zqtA-5e4vA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g4q DNA POLYMERASE III
SUBUNIT BETA

(Helicobacter
pylori) 		PF00712
(DNA_pol3_beta)
PF02767
(DNA_pol3_beta_2)
PF02768
(DNA_pol3_beta_3) 		5 LEU A 332
LEU A 329
LEU A 326
VAL A 320
THR A 367
 None
 1.01A 3zqtA-5g4qA:
undetectable		 3zqtA-5g4qA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gw5 T-COMPLEX PROTEIN 1
SUBUNIT ALPHA

(Saccharomyces
cerevisiae) 		PF00118
(Cpn60_TCP1) 		5 LEU a  44
LEU a 462
ASN a 465
LEU a 504
VAL a 474
 None
 1.24A 3zqtA-5gw5a:
undetectable		 3zqtA-5gw5a:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gw5 T-COMPLEX PROTEIN 1
SUBUNIT BETA

(Saccharomyces
cerevisiae) 		PF00118
(Cpn60_TCP1) 		5 LEU b  37
LEU b 444
ASN b 447
LEU b 474
VAL b 456
 None
 1.34A 3zqtA-5gw5b:
2.2		 3zqtA-5gw5b:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j68 ASTROTACTIN-2

(Homo sapiens) 		PF01823
(MACPF) 		5 LEU A 788
LEU A1021
LEU A1034
VAL A1031
THR A1024
 None
 1.29A 3zqtA-5j68A:
undetectable		 3zqtA-5j68A:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jjt SERINE/THREONINE-PRO
TEIN PHOSPHATASE 5

(Arabidopsis
thaliana) 		PF00149
(Metallophos)
PF00515
(TPR_1)
PF08321
(PPP5)
PF13431
(TPR_17) 		5 LEU A 285
LEU A 272
VAL A 177
MET A 181
THR A 202
 None
 1.29A 3zqtA-5jjtA:
undetectable		 3zqtA-5jjtA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jm7 AEROBACTIN SYNTHASE
IUCA

(Klebsiella
pneumoniae) 		PF04183
(IucA_IucC)
PF06276
(FhuF) 		5 LEU A 362
LEU A 365
LEU A 376
VAL A 381
ARG A 383
 None
 1.39A 3zqtA-5jm7A:
undetectable		 3zqtA-5jm7A:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mwp MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		no annotation 6 LEU A 766
LEU A 769
ASN A 770
LEU A 772
MET A 807
ARG A 817
 ECV  A1101 ( 3.9A)
ECV  A1101 (-4.7A)
ECV  A1101 (-3.1A)
ECV  A1101 ( 3.9A)
ECV  A1101 (-3.6A)
ECV  A1101 (-4.0A)
 0.61A 3zqtA-5mwpA:
37.2		 3zqtA-5mwpA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n94 CG9323, ISOFORM A

(Drosophila
melanogaster) 		no annotation 5 LEU A 618
LEU A 612
LEU A 611
GLN A 639
THR A 625
 None
 1.33A 3zqtA-5n94A:
undetectable		 3zqtA-5n94A:
14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ubm COMPLEMENT C1S
SUBCOMPONENT

(Homo sapiens) 		no annotation 5 LEU A 471
LEU A 532
VAL A 672
MET A 676
THR A 666
 None
 1.41A 3zqtA-5ubmA:
undetectable		 3zqtA-5ubmA:
21.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5uc1 GLUCOCORTICOID
RECEPTOR

(Heterocephalus
glaber) 		no annotation 5 LEU A 559
ASN A 560
LEU A 562
MET A 600
ARG A 607
 486  A 801 (-4.7A)
486  A 801 (-4.2A)
486  A 801 ( 4.8A)
None
486  A 801 (-3.5A)
 0.73A 3zqtA-5uc1A:
23.3		 3zqtA-5uc1A:
50.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5uc1 GLUCOCORTICOID
RECEPTOR

(Heterocephalus
glaber) 		no annotation 5 LEU A 559
ASN A 560
MET A 597
MET A 600
ARG A 607
 486  A 801 (-4.7A)
486  A 801 (-4.2A)
CPS  A 803 ( 3.9A)
None
486  A 801 (-3.5A)
 0.85A 3zqtA-5uc1A:
23.3		 3zqtA-5uc1A:
50.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ufs ANCESTRAL
GLUCOCORTICOID
RECEPTOR2

(unidentified) 		PF00104
(Hormone_recep) 		6 LEU A  32
ASN A  33
LEU A  35
MET A  70
MET A  73
ARG A  80
 1TA  A 301 (-3.5A)
1TA  A 301 (-3.0A)
1TA  A 301 ( 3.6A)
1TA  A 301 ( 3.1A)
1TA  A 301 (-4.2A)
1TA  A 301 (-3.5A)
 0.87A 3zqtA-5ufsA:
35.5		 3zqtA-5ufsA:
54.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ufs ANCESTRAL
GLUCOCORTICOID
RECEPTOR2

(unidentified) 		PF00104
(Hormone_recep) 		5 LEU A  35
GLN A  39
MET A  70
MET A  73
ARG A  80
 1TA  A 301 ( 3.6A)
1TA  A 301 (-3.0A)
1TA  A 301 ( 3.1A)
1TA  A 301 (-4.2A)
1TA  A 301 (-3.5A)
 0.97A 3zqtA-5ufsA:
35.5		 3zqtA-5ufsA:
54.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xcb PROBABLE SURFACE
PROTEIN

(Clostridium
perfringens) 		no annotation 5 LEU A  75
LEU A  57
ASN A  72
LEU A  58
VAL A 155
 None
 1.25A 3zqtA-5xcbA:
undetectable		 3zqtA-5xcbA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6caa ELECTROGENIC SODIUM
BICARBONATE
COTRANSPORTER 1

(Homo sapiens) 		no annotation 5 LEU A 923
LEU A 920
LEU A 917
GLN A 913
VAL A 940
 None
 1.41A 3zqtA-6caaA:
undetectable		 3zqtA-6caaA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eu6 AMMONIUM TRANSPORTER

(Candidatus
Kuenenia
stuttgartiensis) 		no annotation 5 LEU A 357
LEU A 346
MET A 286
VAL A 287
THR A 334
 None
 1.29A 3zqtA-6eu6A:
undetectable		 3zqtA-6eu6A:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6geb DOTB

(Legionella
pneumophila) 		no annotation 5 LEU A  65
ASN A  62
LEU A  60
MET A  21
THR A  78
 None
 1.42A 3zqtA-6gebA:
undetectable		 3zqtA-6gebA:
14.46