SIMILAR PATTERNS OF AMINO ACIDS FOR 3ZQ8_D_DVAD6_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gi2 CROTONYL-COA
CARBOXYLASE/REDUCTAS
E

(Methylobacterium
extorquens) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 TRP A 217
TRP A 282
ALA A 313
VAL A 317
 None
 0.96A 3zq8C-4gi2A:
undetectable
3zq8D-4gi2A:
undetectable		 3zq8C-4gi2A:
5.09
3zq8D-4gi2A:
5.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pxn UNCHARACTERIZED
PROTEIN

(Zea mays) 		PF00171
(Aldedh) 		4 TRP A 188
TRP A 174
ALA A 176
VAL A 171
 None
 1.47A 3zq8C-4pxnA:
undetectable
3zq8D-4pxnA:
undetectable		 3zq8C-4pxnA:
2.60
3zq8D-4pxnA:
2.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nit GLUCOSE OXIDASE

(Aspergillus
niger) 		no annotation 4 TRP A 133
TRP A 122
ALA A 117
VAL A 119
 DIO  A 610 ( 3.9A)
None
None
DIO  A 610 ( 4.9A)
 1.28A 3zq8C-5nitA:
undetectable
3zq8D-5nitA:
undetectable		 3zq8C-5nitA:
2.74
3zq8D-5nitA:
2.74