SIMILAR PATTERNS OF AMINO ACIDS FOR 3ZOS_B_0LIB1000_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gng GLYCOGEN SYNTHASE
KINASE-3 BETA

(Homo sapiens) 		PF00069
(Pkinase) 		5 ILE A 100
MET A 101
LEU A 104
ILE A 109
TYR A 134
 None
 0.59A 3zosB-1gngA:
20.3		 3zosB-1gngA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1go3 DNA-DIRECTED RNA
POLYMERASE SUBUNIT E
DNA-DIRECTED RNA
POLYMERASE SUBUNIT F

(Methanocaldococcus
jannaschii) 		PF00575
(S1)
PF03874
(RNA_pol_Rpb4)
PF03876
(SHS2_Rpb7-N) 		5 LEU F  41
LEU F  59
ILE F  72
TYR E   2
MET E   1
 None
 1.20A 3zosB-1go3F:
undetectable		 3zosB-1go3F:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h09 LYSOZYME

(Streptococcus
virus Cp1) 		PF01183
(Glyco_hydro_25)
PF01473
(CW_binding_1) 		5 LEU A  89
ILE A 185
LEU A 187
ILE A 171
ILE A 150
 None
 1.25A 3zosB-1h09A:
undetectable		 3zosB-1h09A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1itx GLYCOSYL HYDROLASE

(Bacillus
circulans) 		PF00704
(Glyco_hydro_18) 		5 LEU A 118
ILE A 250
LEU A 248
ILE A 231
TYR A 194
 None
 1.22A 3zosB-1itxA:
undetectable		 3zosB-1itxA:
20.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1luf MUSCLE-SPECIFIC
TYROSINE KINASE
RECEPTOR MUSK

(Rattus
norvegicus) 		PF07714
(Pkinase_Tyr) 		5 MET A 629
ILE A 637
TYR A 656
MET A 657
ILE A 740
 None
 0.71A 3zosB-1lufA:
35.7		 3zosB-1lufA:
39.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tua HYPOTHETICAL PROTEIN
APE0754

(Aeropyrum
pernix) 		PF00013
(KH_1) 		5 LEU A 156
ILE A 111
MET A 125
TYR A 129
ILE A 112
 None
 1.26A 3zosB-1tuaA:
undetectable		 3zosB-1tuaA:
20.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1u59 TYROSINE-PROTEIN
KINASE ZAP-70

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 344
ILE A 389
LEU A 393
ILE A 398
ILE A 477
 STU  A 100 (-3.8A)
None
None
None
None
 0.81A 3zosB-1u59A:
29.0		 3zosB-1u59A:
33.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1u59 TYROSINE-PROTEIN
KINASE ZAP-70

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 344
ILE A 389
MET A 390
ILE A 398
ILE A 477
 STU  A 100 (-3.8A)
None
None
None
None
 0.75A 3zosB-1u59A:
29.0		 3zosB-1u59A:
33.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A  15
ILE A  58
LEU A  62
TYR A  86
ILE A 146
 HYM  A 400 (-4.2A)
None
None
HYM  A 400 (-4.7A)
None
 0.73A 3zosB-1zltA:
20.3		 3zosB-1zltA:
24.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU X  17
ILE X  57
MET X  58
TYR X  84
MET X  85
ILE X 146
 STU  X 902 (-3.8A)
None
None
STU  X 902 (-4.6A)
None
None
 0.69A 3zosB-2dq7X:
29.9		 3zosB-2dq7X:
35.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hak SERINE/THREONINE-PRO
TEIN KINASE MARK1

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		5 ILE A 103
LEU A 107
ILE A 112
TYR A 131
ILE A 191
 None
 0.68A 3zosB-2hakA:
20.2		 3zosB-2hakA:
26.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i2x METHYLTRANSFERASE 1

(Methanosarcina
barkeri) 		PF12176
(MtaB) 		5 LEU A 161
ILE A 108
MET A 109
ILE A  81
ILE A  43
 None
 1.29A 3zosB-2i2xA:
undetectable		 3zosB-2i2xA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i6l MITOGEN-ACTIVATED
PROTEIN KINASE 6

(Homo sapiens) 		PF00069
(Pkinase) 		6 ILE A  68
LEU A  72
ILE A  77
TYR A 110
MET A 111
ILE A 169
 None
 0.83A 3zosB-2i6lA:
21.9		 3zosB-2i6lA:
27.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i79 ACETYLTRANSFERASE,
GNAT FAMILY

(Streptococcus
pneumoniae) 		PF00583
(Acetyltransf_1) 		5 LEU A  41
ILE A  92
LEU A  90
ILE A  76
ILE A  60
 None
ACO  A 402 (-4.7A)
None
None
None
 1.00A 3zosB-2i79A:
undetectable		 3zosB-2i79A:
21.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2og8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 251
MET A 292
TYR A 318
MET A 319
ILE A 380
 None
1N8  A 501 ( 3.6A)
1N8  A 501 ( 3.7A)
1N8  A 501 ( 4.4A)
None
 0.72A 3zosB-2og8A:
30.9		 3zosB-2og8A:
37.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ogv MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
PRECURSOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 588
ILE A 636
MET A 637
ILE A 646
TYR A 665
ILE A 794
 None
 0.97A 3zosB-2ogvA:
32.8		 3zosB-2ogvA:
35.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 487
MET A 538
ILE A 547
TYR A 566
ILE A 642
 None
 0.70A 3zosB-2psqA:
23.7		 3zosB-2psqA:
33.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2r2p EPHRIN TYPE-A
RECEPTOR 5

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		5 ILE A 727
MET A 728
ILE A 736
TYR A 755
MET A 756
 None
 0.68A 3zosB-2r2pA:
30.7		 3zosB-2r2pA:
35.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v6z DNA POLYMERASE
EPSILON SUBUNIT 2

(Homo sapiens) 		PF12213
(Dpoe2NT) 		5 LEU M  63
ILE M  50
LEU M  53
ILE M  72
ILE M  73
 None
 1.25A 3zosB-2v6zM:
undetectable		 3zosB-2v6zM:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y4o PHENYLACETATE-COENZY
ME A LIGASE

(Burkholderia
cenocepacia) 		PF00501
(AMP-binding)
PF14535
(AMP-binding_C_2) 		5 LEU A 193
ILE A 151
LEU A 136
ILE A 184
ILE A 213
 None
 1.24A 3zosB-2y4oA:
undetectable		 3zosB-2y4oA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2za1 OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE

(Plasmodium
falciparum) 		PF00215
(OMPdecase) 		5 LEU A   7
ILE A 316
LEU A 273
ILE A 266
ILE A 292
 None
 1.18A 3zosB-2za1A:
undetectable		 3zosB-2za1A:
21.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 487
MET A 538
ILE A 547
TYR A 566
ILE A 642
 M33  A1996 (-4.0A)
None
None
M33  A1996 ( 4.7A)
None
 0.60A 3zosB-3b2tA:
23.4		 3zosB-3b2tA:
34.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 484
MET A 535
ILE A 544
TYR A 563
ILE A 639
 C4F  A   1 ( 3.9A)
C4F  A   1 ( 3.7A)
None
None
None
 0.62A 3zosB-3c4fA:
24.5		 3zosB-3c4fA:
37.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d9y PROFILIN

(Schizosaccharomyces
pombe) 		PF00235
(Profilin) 		5 LEU A 121
ILE A  61
LEU A  63
TYR A   5
ILE A  43
 None
 1.15A 3zosB-3d9yA:
undetectable		 3zosB-3d9yA:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e3b CASEIN KINASE II
SUBUNIT ALPHA'

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU X  46
ILE X  85
LEU X  89
ILE X  95
TYR X 116
 CCK  X 351 (-4.0A)
None
None
None
CCK  X 351 (-4.3A)
 0.84A 3zosB-3e3bX:
11.9		 3zosB-3e3bX:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e3p PROTEIN KINASE,
PUTATIVE GLYCOGEN
SYNTHASE KINASE

(Leishmania
major) 		PF00069
(Pkinase) 		5 LEU A  36
ILE A  64
MET A  65
LEU A  68
ILE A  76
 None
 1.17A 3zosB-3e3pA:
18.4		 3zosB-3e3pA:
24.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eb0 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		6 LEU A  15
ILE A  53
MET A  54
LEU A  57
ILE A  62
TYR A 119
 DRK  A 384 (-3.8A)
None
None
None
None
DRK  A 384 (-4.4A)
 0.50A 3zosB-3eb0A:
21.0		 3zosB-3eb0A:
24.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fe3 MAP/MICROTUBULE
AFFINITY-REGULATING
KINASE 3

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		5 ILE A 106
LEU A 110
ILE A 115
TYR A 134
ILE A 194
 None
 0.89A 3zosB-3fe3A:
15.5		 3zosB-3fe3A:
25.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3fzp PROTEIN TYROSINE
KINASE 2 BETA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 431
ILE A 477
MET A 478
LEU A 481
ILE A 486
 AGS  A 999 ( 4.4A)
None
None
None
None
 1.14A 3zosB-3fzpA:
30.3		 3zosB-3fzpA:
33.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gf7 GLUTACONYL-COA
DECARBOXYLASE
SUBUNIT A

([Clostridium]
symbiosum) 		PF01039
(Carboxyl_trans) 		5 LEU A 371
ILE A 330
LEU A 414
ILE A 454
ILE A 316
 None
 1.13A 3zosB-3gf7A:
undetectable		 3zosB-3gf7A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hdg UNCHARACTERIZED
PROTEIN

(Wolinella
succinogenes) 		PF00072
(Response_reg) 		5 LEU A 101
ILE A 111
LEU A  24
ILE A  13
ILE A  11
 None
 1.23A 3zosB-3hdgA:
undetectable		 3zosB-3hdgA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		5 ILE A 103
LEU A 107
ILE A 112
TYR A 131
ILE A 191
 None
 0.82A 3zosB-3iecA:
22.0		 3zosB-3iecA:
26.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		5 ILE A 103
MET A 104
ILE A 112
TYR A 131
ILE A 191
 None
 0.99A 3zosB-3iecA:
22.0		 3zosB-3iecA:
26.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kul EPHRIN TYPE-A
RECEPTOR 8

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		5 ILE A 687
MET A 688
ILE A 696
TYR A 715
MET A 716
 None
None
None
GOL  A 403 (-4.1A)
None
 0.89A 3zosB-3kulA:
24.5		 3zosB-3kulA:
37.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l77 SHORT-CHAIN ALCOHOL
DEHYDROGENASE

(Thermococcus
sibiricus) 		PF00106
(adh_short) 		5 LEU A  89
ILE A  41
LEU A  30
ILE A   6
ILE A  17
 None
 1.20A 3zosB-3l77A:
undetectable		 3zosB-3l77A:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m1r FORMIMIDOYLGLUTAMASE

(Bacillus
subtilis) 		PF00491
(Arginase) 		5 LEU A 307
ILE A  34
LEU A  87
ILE A  40
ILE A 122
 None
 1.01A 3zosB-3m1rA:
undetectable		 3zosB-3m1rA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mn3 CARBON
CATABOLITE-DEREPRESS
ING PROTEIN KINASE

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		5 LEU A  61
LEU A 110
ILE A 115
TYR A 134
ILE A 193
 None
 0.69A 3zosB-3mn3A:
14.3		 3zosB-3mn3A:
29.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nuu PKB-LIKE

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A  88
MET A 134
LEU A 137
TYR A 161
ILE A 221
 JOZ  A 361 (-4.1A)
None
None
None
None
 0.80A 3zosB-3nuuA:
22.8		 3zosB-3nuuA:
25.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nzp ARGININE
DECARBOXYLASE

(Campylobacter
jejuni) 		PF02784
(Orn_Arg_deC_N) 		5 LEU A 223
ILE A 129
LEU A 116
ILE A 142
ILE A 145
 None
 1.20A 3zosB-3nzpA:
undetectable		 3zosB-3nzpA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pf2 CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN

(Streptococcus
agalactiae) 		PF16569
(GramPos_pilinBB)
PF16570
(GramPos_pilinD3) 		5 ILE A 302
LEU A 271
ILE A 264
MET A 309
ILE A 333
 None
 1.27A 3zosB-3pf2A:
undetectable		 3zosB-3pf2A:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pnr FALCIPAIN 2

(Plasmodium
falciparum) 		PF00112
(Peptidase_C1) 		5 LEU A  65
ILE A 202
LEU A 178
ILE A 146
TYR A  55
 None
 1.02A 3zosB-3pnrA:
undetectable		 3zosB-3pnrA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ps5 TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 6

(Homo sapiens) 		PF00017
(SH2)
PF00102
(Y_phosphatase) 		5 LEU A 523
ILE A 466
LEU A 469
ILE A 482
ILE A 223
 None
 1.25A 3zosB-3ps5A:
undetectable		 3zosB-3ps5A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rh9 SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(NAD(P)(+))

(Marinobacter
hydrocarbonoclasticus) 		PF00171
(Aldedh) 		5 ILE A 189
LEU A   7
ILE A   2
MET A 321
ILE A  38
 None
 1.26A 3zosB-3rh9A:
undetectable		 3zosB-3rh9A:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tac LIPRIN-ALPHA-2

(Homo sapiens) 		PF00536
(SAM_1)
PF07647
(SAM_2) 		5 ILE B 930
MET B 931
LEU B 934
ILE B 939
MET B 913
 None
 1.20A 3zosB-3tacB:
undetectable		 3zosB-3tacB:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tsd INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Bacillus
anthracis) 		PF00478
(IMPDH)
PF00571
(CBS) 		5 LEU A 454
LEU A  69
ILE A  47
MET A 350
ILE A 339
 None
 1.20A 3zosB-3tsdA:
undetectable		 3zosB-3tsdA:
21.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3tt0 BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 484
MET A 535
ILE A 544
TYR A 563
ILE A 639
 07J  A   1 ( 4.3A)
07J  A   1 (-3.8A)
None
07J  A   1 (-4.7A)
None
 0.70A 3zosB-3tt0A:
30.3		 3zosB-3tt0A:
31.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3v5q NT-3 GROWTH FACTOR
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 544
ILE A 600
MET A 615
TYR A 619
MET A 620
ILE A 695
 0F4  A 902 ( 4.2A)
0F4  A 902 (-4.1A)
None
0F4  A 902 (-4.2A)
None
0F4  A 902 (-4.6A)
 0.63A 3zosB-3v5qA:
26.7		 3zosB-3v5qA:
45.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vo2 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Zea mays) 		PF00175
(NAD_binding_1) 		5 ILE A 166
LEU A 168
ILE A 281
MET A 297
ILE A 284
 None
 1.15A 3zosB-3vo2A:
undetectable		 3zosB-3vo2A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4af3 AURORA KINASE B

(Homo sapiens) 		PF00069
(Pkinase) 		5 ILE A 128
LEU A 132
ILE A 137
TYR A 156
ILE A 216
 None
None
None
VX6  A 500 (-4.2A)
None
 1.01A 3zosB-4af3A:
19.5		 3zosB-4af3A:
26.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4at3 BDNF/NT-3 GROWTH
FACTORS RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 560
ILE A 616
MET A 631
TYR A 635
MET A 636
ILE A 708
 LTI  A1839 ( 4.2A)
None
None
LTI  A1839 (-4.7A)
None
None
 0.72A 3zosB-4at3A:
32.1		 3zosB-4at3A:
47.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cfh 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1

(Rattus
norvegicus) 		PF00069
(Pkinase)
PF16579
(AdenylateSensor) 		5 LEU A  22
ILE A  76
MET A  91
TYR A  95
ILE A 155
 STU  A1550 (-4.3A)
None
None
STU  A1550 (-4.5A)
None
 0.72A 3zosB-4cfhA:
22.4		 3zosB-4cfhA:
21.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ckr EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 LEU A 616
ILE A 675
MET A 676
LEU A 679
ILE A 684
MET A 699
TYR A 703
MET A 704
ILE A 782
 None
None
DI1  A1000 (-3.6A)
DI1  A1000 (-4.5A)
DI1  A1000 ( 4.5A)
DI1  A1000 ( 4.1A)
DI1  A1000 (-4.0A)
None
DI1  A1000 (-4.5A)
 0.54A 3zosB-4ckrA:
43.7		 3zosB-4ckrA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eqm PROTEIN KINASE

(Staphylococcus
aureus) 		PF00069
(Pkinase) 		5 LEU A  16
LEU A  65
ILE A  70
TYR A  89
ILE A 149
 ANP  A 300 (-4.7A)
None
None
ANP  A 300 (-4.3A)
None
 0.71A 3zosB-4eqmA:
22.3		 3zosB-4eqmA:
26.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f0g SERINE/THREONINE-PRO
TEIN KINASE ROCO4

(Dictyostelium
discoideum) 		PF07714
(Pkinase_Tyr) 		5 ILE A1081
MET A1082
LEU A1085
ILE A1090
MET A1103
 None
 0.77A 3zosB-4f0gA:
19.6		 3zosB-4f0gA:
29.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4f0i HIGH AFFINITY NERVE
GROWTH FACTOR
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 515
ILE A 571
MET A 586
TYR A 590
MET A 591
ILE A 665
 None
 0.74A 3zosB-4f0iA:
33.5		 3zosB-4f0iA:
44.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f4f THREONINE SYNTHASE

(Brucella
melitensis) 		PF00291
(PALP)
PF14821
(Thr_synth_N) 		5 LEU A 383
ILE A 310
LEU A 286
ILE A 278
ILE A 260
 None
 1.13A 3zosB-4f4fA:
undetectable		 3zosB-4f4fA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4flx DNA POLYMERASE 1

(Pyrococcus
abyssi) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		5 LEU A 322
ILE A 198
LEU A 194
ILE A 160
ILE A 142
 LEU  A 322 ( 0.6A)
ILE  A 198 ( 0.7A)
LEU  A 194 ( 0.5A)
ILE  A 160 ( 0.7A)
ILE  A 142 (-0.7A)
 1.25A 3zosB-4flxA:
undetectable		 3zosB-4flxA:
18.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4fod ALK TYROSINE KINASE
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A1122
ILE A1170
ILE A1179
MET A1199
ILE A1268
 0UV  A1501 (-3.8A)
None
None
None
None
 0.82A 3zosB-4fodA:
23.5		 3zosB-4fodA:
34.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fr4 SERINE/THREONINE-PRO
TEIN KINASE 32A

(Homo sapiens) 		PF00069
(Pkinase) 		5 ILE A  74
MET A  75
LEU A  78
MET A  98
ILE A 162
 None
 1.08A 3zosB-4fr4A:
20.7		 3zosB-4fr4A:
23.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4gl9 TYROSINE-PROTEIN
KINASE

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		5 LEU A 855
ILE A 901
ILE A 910
TYR A 931
ILE A 992
 IZA  A2001 (-3.7A)
None
None
None
None
 0.69A 3zosB-4gl9A:
28.3		 3zosB-4gl9A:
33.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4gl9 TYROSINE-PROTEIN
KINASE

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		5 LEU A 855
ILE A 901
LEU A 905
ILE A 910
ILE A 992
 IZA  A2001 (-3.7A)
None
None
None
None
 0.71A 3zosB-4gl9A:
28.3		 3zosB-4gl9A:
33.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hpf POTASSIUM CHANNEL
SUBFAMILY U MEMBER 1

(Homo sapiens) 		PF03493
(BK_channel_a) 		5 LEU A 367
ILE A 472
LEU A 458
ILE A 430
MET A 395
 None
 1.16A 3zosB-4hpfA:
undetectable		 3zosB-4hpfA:
18.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hvi TYROSINE-PROTEIN
KINASE JAK3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 828
ILE A 874
LEU A 878
ILE A 883
TYR A 904
ILE A 965
 19S  A1201 (-3.9A)
None
None
None
19S  A1201 (-4.7A)
None
 0.66A 3zosB-4hviA:
29.2		 3zosB-4hviA:
33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4k33 FIBROBLAST GROWTH
FACTOR RECEPTOR 3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 478
MET A 529
ILE A 538
TYR A 557
ILE A 633
 ACP  A 801 (-3.8A)
None
None
None
None
 0.67A 3zosB-4k33A:
6.1		 3zosB-4k33A:
34.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mvf CALCIUM-DEPENDENT
PROTEIN KINASE 2

(Plasmodium
falciparum) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		5 ILE A 120
MET A 121
LEU A 124
ILE A 129
ILE A 211
 None
 0.79A 3zosB-4mvfA:
19.5		 3zosB-4mvfA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 903
ILE A 950
ILE A 959
TYR A 980
ILE A1039
 2TT  A1202 (-3.5A)
None
None
2TT  A1202 (-4.6A)
None
 0.58A 3zosB-4oliA:
26.3		 3zosB-4oliA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 903
ILE A 950
LEU A 954
ILE A 959
ILE A1039
 2TT  A1202 (-3.5A)
None
None
None
None
 0.74A 3zosB-4oliA:
26.3		 3zosB-4oliA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qlz SJCHGC07024 PROTEIN

(Schistosoma
japonicum) 		PF00719
(Pyrophosphatase) 		5 LEU A  32
ILE A 169
ILE A 122
MET A  43
ILE A 156
 None
 1.22A 3zosB-4qlzA:
undetectable		 3zosB-4qlzA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rd8 UNCHARACTERIZED
PROTEIN

(Legionella
pneumophila) 		no annotation 5 LEU A  99
ILE A 131
ILE A 182
MET A  90
MET A 105
 None
 1.26A 3zosB-4rd8A:
undetectable		 3zosB-4rd8A:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4red 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A  24
ILE A  78
MET A  93
TYR A  97
ILE A 157
 None
 0.73A 3zosB-4redA:
13.9		 3zosB-4redA:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rew 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1

(Homo sapiens) 		PF00069
(Pkinase)
PF16579
(AdenylateSensor) 		5 LEU A  24
ILE A  78
MET A  93
TYR A  97
ILE A 157
 STU  A 601 (-3.7A)
None
None
STU  A 601 (-4.4A)
None
 0.63A 3zosB-4rewA:
22.2		 3zosB-4rewA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rxt SUGAR ABC
TRANSPORTER

(Agrobacterium
tumefaciens) 		PF13407
(Peripla_BP_4) 		5 LEU A  63
LEU A  70
ILE A  40
TYR A 284
ILE A  96
 None
 1.21A 3zosB-4rxtA:
undetectable		 3zosB-4rxtA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wbo RHODOPSIN KINASE

(Bos taurus) 		PF00069
(Pkinase)
PF00615
(RGS) 		5 LEU A 193
ILE A 238
ILE A 247
MET A 267
ILE A 330
 ANW  A 601 ( 4.0A)
None
None
None
None
 1.01A 3zosB-4wboA:
21.9		 3zosB-4wboA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4znj PHAGE TERMINASE
LARGE SUBUNIT

(Thermus virus
P74-26) 		PF03237
(Terminase_6) 		5 LEU A  87
ILE A  25
LEU A 175
ILE A 147
ILE A  76
 None
 1.23A 3zosB-4znjA:
undetectable		 3zosB-4znjA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zxi TYROCIDINE
SYNTHETASE 3

(Acinetobacter
baumannii) 		PF00501
(AMP-binding)
PF00550
(PP-binding)
PF00668
(Condensation)
PF00975
(Thioesterase)
PF13193
(AMP-binding_C) 		5 LEU A 736
ILE A 485
MET A 681
ILE A 643
ILE A 642
 None
 1.26A 3zosB-4zxiA:
undetectable		 3zosB-4zxiA:
14.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 484
MET A 535
ILE A 544
TYR A 563
ILE A 639
 38O  A1769 (-3.2A)
EDO  A1766 (-3.5A)
None
38O  A1769 (-4.2A)
None
 0.76A 3zosB-5a46A:
30.6		 3zosB-5a46A:
31.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bpt MGC81278 PROTEIN

(Xenopus laevis) 		PF12894
(ANAPC4_WD40)
PF12896
(ANAPC4) 		5 LEU A 530
ILE A  72
LEU A  94
ILE A 148
ILE A 157
 None
 1.28A 3zosB-5bptA:
2.1		 3zosB-5bptA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dm4 METHYLTRANSFERASE
DOMAIN FAMILY

(Bacillus
pumilus) 		PF13489
(Methyltransf_23) 		5 LEU A 134
ILE A 201
LEU A 254
ILE A 155
ILE A 126
 SAH  A 300 ( 4.3A)
None
None
None
None
 1.26A 3zosB-5dm4A:
undetectable		 3zosB-5dm4A:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5es1 MAP/MICROTUBULE
AFFINITY-REGULATING
KINASE 4

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		5 ILE A 106
LEU A 110
ILE A 115
TYR A 134
ILE A 194
 None
None
None
5RC  A4000 (-4.5A)
None
 0.83A 3zosB-5es1A:
22.5		 3zosB-5es1A:
25.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ILE A 950
LEU A 954
ILE A 959
TYR A 980
ILE A1039
 None
None
None
5U3  A1200 (-4.5A)
None
 0.73A 3zosB-5f1zA:
27.1		 3zosB-5f1zA:
34.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 903
ILE A 950
ILE A 959
TYR A 980
ILE A1039
 5U3  A1200 (-3.8A)
None
None
5U3  A1200 (-4.5A)
None
 0.46A 3zosB-5f1zA:
27.1		 3zosB-5f1zA:
34.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 599
ILE A 647
MET A 648
ILE A 657
TYR A 676
ILE A 834
 748  A1001 (-3.8A)
748  A1001 ( 4.0A)
748  A1001 (-3.4A)
748  A1001 ( 4.4A)
748  A1001 (-4.0A)
748  A1001 (-4.8A)
 0.84A 3zosB-5grnA:
28.1		 3zosB-5grnA:
30.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i3o BMP-2-INDUCIBLE
PROTEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A  57
ILE A  98
MET A  99
ILE A 108
TYR A 132
 IDV  A 401 (-3.8A)
None
None
None
IDV  A 401 (-3.5A)
 0.95A 3zosB-5i3oA:
21.6		 3zosB-5i3oA:
26.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ig1 CAMK/CAMK2 PROTEIN
KINASE

(Salpingoeca
rosetta) 		PF00069
(Pkinase) 		5 ILE A  68
LEU A  72
ILE A  77
TYR A  96
ILE A 159
 None
None
None
PO4  A 401 (-4.8A)
None
 0.74A 3zosB-5ig1A:
23.2		 3zosB-5ig1A:
26.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iso 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2

(Homo sapiens) 		PF00069
(Pkinase)
PF16579
(AdenylateSensor) 		5 LEU A  22
ILE A  76
MET A  91
TYR A  95
ILE A 155
 STU  A 601 (-4.1A)
None
None
STU  A 601 (-4.3A)
None
 0.71A 3zosB-5isoA:
22.6		 3zosB-5isoA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5of4 GENERAL
TRANSCRIPTION FACTOR
IIH SUBUNIT 2
TFIIH BASAL
TRANSCRIPTION FACTOR
COMPLEX HELICASE XPD
SUBUNIT

(Homo sapiens) 		PF04056
(Ssl1)
PF06733
(DEAD_2)
PF06777
(HBB)
PF13307
(Helicase_C_2) 		5 ILE E 169
LEU E 145
ILE E 182
TYR B 614
ILE E 186
 None
 1.27A 3zosB-5of4E:
undetectable		 3zosB-5of4E:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u8s DNA REPLICATION
LICENSING FACTOR
MCM4

(Saccharomyces
cerevisiae) 		PF00493
(MCM)
PF14551
(MCM_N)
PF17207
(MCM_OB) 		5 ILE 4 829
LEU 4 704
ILE 4 564
MET 4 649
ILE 4 562
 None
 1.15A 3zosB-5u8s4:
2.3		 3zosB-5u8s4:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uuw INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Bacillus
anthracis) 		PF00478
(IMPDH) 		5 LEU A 454
LEU A  69
ILE A  47
MET A 350
ILE A 339
 None
 1.21A 3zosB-5uuwA:
undetectable		 3zosB-5uuwA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w4l ANTIBODY N12-I3 FAB
HEAVY CHAIN

(Homo sapiens) 		no annotation 5 LEU D  45
ILE D  52
ILE D  69
TYR D  91
ILE D  67
 None
 1.29A 3zosB-5w4lD:
undetectable		 3zosB-5w4lD:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w5j RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2

(Homo sapiens) 		no annotation 5 LEU A  24
ILE A  78
TYR A  97
MET A  98
ILE A 162
 9WS  A 401 ( 4.2A)
None
None
None
None
 0.47A 3zosB-5w5jA:
22.2		 3zosB-5w5jA:
27.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w5j RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2

(Homo sapiens) 		no annotation 5 LEU A  24
ILE A 162
TYR A  97
MET A  98
ILE A 152
 9WS  A 401 ( 4.2A)
None
None
None
None
 0.83A 3zosB-5w5jA:
22.2		 3zosB-5w5jA:
27.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wnm RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 4

(Mus musculus) 		no annotation 5 MET A  73
ILE A  81
TYR A  98
MET A  99
ILE A 159
 None
None
VX6  A 402 (-4.3A)
None
None
 0.72A 3zosB-5wnmA:
26.0		 3zosB-5wnmA:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xu1 ABC TRANSPORTER
ATP-BINDING PROTEIN

(Streptococcus
pneumoniae) 		no annotation 5 ILE A 183
LEU A 187
ILE A 197
MET A  51
ILE A 166
 None
 1.21A 3zosB-5xu1A:
undetectable		 3zosB-5xu1A:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xwy A TYPE VI-A
CRISPR-CAS
RNA-GUIDED RNA
RIBONUCLEASE, CAS13A

(Leptotrichia
buccalis) 		no annotation 5 LEU A 596
ILE A 550
ILE A 681
TYR A 560
ILE A 684
 None
 1.09A 3zosB-5xwyA:
undetectable		 3zosB-5xwyA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bx6 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2

(Homo sapiens) 		no annotation 5 LEU A  22
ILE A  76
MET A  91
TYR A  95
ILE A 155
 EDJ  A 301 (-3.9A)
None
None
EDJ  A 301 ( 4.8A)
None
 0.45A 3zosB-6bx6A:
18.8		 3zosB-6bx6A:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c6k INTERFERON-INDUCED
PROTEIN WITH
TETRATRICOPEPTIDE
REPEATS 1

(Homo sapiens) 		no annotation 5 LEU A 459
ILE A 401
LEU A 405
ILE A 408
ILE A 421
 None
 1.28A 3zosB-6c6kA:
undetectable		 3zosB-6c6kA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c7y TYROSINE-PROTEIN
KINASE JAK1

(Homo sapiens) 		no annotation 5 LEU A 881
ILE A 928
LEU A 932
ILE A 937
ILE A1019
 ADP  A1201 ( 4.5A)
None
None
None
None
 0.71A 3zosB-6c7yA:
20.0		 3zosB-6c7yA:
12.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c9d SERINE/THREONINE-PRO
TEIN KINASE
MARK1,SERINE/THREONI
NE-PROTEIN KINASE
MARK1

(Homo sapiens) 		no annotation 5 ILE A 110
LEU A 114
ILE A 119
TYR A 138
ILE A 198
 None
 0.80A 3zosB-6c9dA:
21.2		 3zosB-6c9dA:
11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c9d SERINE/THREONINE-PRO
TEIN KINASE
MARK1,SERINE/THREONI
NE-PROTEIN KINASE
MARK1

(Homo sapiens) 		no annotation 5 ILE A 110
MET A 111
ILE A 119
TYR A 138
ILE A 198
 None
 0.98A 3zosB-6c9dA:
21.2		 3zosB-6c9dA:
11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f5d ATP SYNTHASE SUBUNIT
BETA

(Trypanosoma
brucei) 		no annotation 5 LEU D 150
ILE D 309
LEU D 258
ILE D 260
ILE D 263
 None
 1.16A 3zosB-6f5dD:
undetectable		 3zosB-6f5dD:
12.18