SIMILAR PATTERNS OF AMINO ACIDS FOR 3ZOS_B_0LIB1000_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k9a CARBOXYL-TERMINAL
SRC KINASE

(Rattus
norvegicus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		8 ALA A 220
LYS A 222
GLU A 236
THR A 266
LEU A 305
HIS A 312
ARG A 313
LEU A 321
 None
 0.63A 3zosB-1k9aA:
28.5		 3zosB-1k9aA:
25.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1luf MUSCLE-SPECIFIC
TYROSINE KINASE
RECEPTOR MUSK

(Rattus
norvegicus) 		PF07714
(Pkinase_Tyr) 		7 ALA A 606
LYS A 608
LEU A 715
HIS A 722
LEU A 731
ALA A 741
ASP A 742
 None
 0.73A 3zosB-1lufA:
35.7		 3zosB-1lufA:
39.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		9 ALA A 288
LYS A 290
GLU A 305
THR A 334
LEU A 373
HIS A 380
ARG A 381
LEU A 389
ALA A 399
 P16  A   2 (-3.4A)
P16  A   2 (-4.5A)
P16  A   2 (-4.2A)
P16  A   2 (-3.7A)
None
None
None
P16  A   2 (-4.4A)
P16  A   2 (-3.5A)
 0.92A 3zosB-1opkA:
29.4		 3zosB-1opkA:
26.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1py5 TGF-BETA RECEPTOR
TYPE I

(Homo sapiens) 		PF00069
(Pkinase)
PF08515
(TGF_beta_GS) 		8 ALA A 230
LYS A 232
GLU A 245
LEU A 316
HIS A 331
ARG A 332
LEU A 340
ALA A 350
 PY1  A 700 (-3.5A)
PY1  A 700 (-3.9A)
PY1  A 700 ( 4.9A)
None
None
None
PY1  A 700 (-4.4A)
PY1  A 700 ( 4.2A)
 0.79A 3zosB-1py5A:
24.2		 3zosB-1py5A:
25.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1rjb FL CYTOKINE RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 642
LYS A 644
GLU A 661
LEU A 802
HIS A 809
LEU A 818
ASP A 829
 None
 0.72A 3zosB-1rjbA:
33.0		 3zosB-1rjbA:
32.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 ALA A 621
LYS A 623
GLU A 640
THR A 670
LEU A 783
HIS A 790
LEU A 799
ASP A 810
PHE A 811
 STI  A   3 (-3.5A)
STI  A   3 (-3.7A)
STI  A   3 (-3.6A)
STI  A   3 (-3.2A)
None
STI  A   3 (-4.5A)
STI  A   3 (-4.4A)
STI  A   3 (-3.9A)
STI  A   3 (-3.6A)
 0.61A 3zosB-1t46A:
34.9		 3zosB-1t46A:
32.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 ALA A 621
LYS A 623
THR A 670
LEU A 783
HIS A 790
ARG A 791
LEU A 799
ASP A 810
PHE A 811
 STI  A   3 (-3.5A)
STI  A   3 (-3.7A)
STI  A   3 (-3.2A)
None
STI  A   3 (-4.5A)
None
STI  A   3 (-4.4A)
STI  A   3 (-3.9A)
STI  A   3 (-3.6A)
 0.75A 3zosB-1t46A:
34.9		 3zosB-1t46A:
32.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u5q SERINE/THREONINE
PROTEIN KINASE TAO2

(Rattus
norvegicus) 		PF00069
(Pkinase) 		8 ALA A  55
LYS A  57
GLU A  76
ILE A  89
LEU A 142
HIS A 149
ARG A 150
LEU A 158
 None
None
None
None
None
None
SEP  A 181 ( 2.8A)
None
 0.77A 3zosB-1u5qA:
23.2		 3zosB-1u5qA:
26.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1

(Homo sapiens) 		PF00069
(Pkinase) 		7 ALA A  36
LYS A  38
GLU A  55
LEU A 121
HIS A 128
ARG A 129
LEU A 137
 HYM  A 400 (-3.5A)
HYM  A 400 (-3.2A)
None
None
None
SO4  A 901 (-2.9A)
HYM  A 400 (-4.5A)
 0.79A 3zosB-1zltA:
20.3		 3zosB-1zltA:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eu9 DUAL SPECIFICITY
PROTEIN KINASE CLK3

(Homo sapiens) 		PF00069
(Pkinase) 		7 ALA A 184
LYS A 186
GLU A 201
LEU A 274
HIS A 281
LEU A 290
ALA A 319
 None
 0.71A 3zosB-2eu9A:
20.9		 3zosB-2eu9A:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f9g MITOGEN-ACTIVATED
PROTEIN KINASE FUS3

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		7 ALA A  40
LYS A  42
GLU A  59
ILE A  72
LEU A 128
HIS A 135
LEU A 144
 ADP  A 500 ( 3.7A)
ADP  A 500 (-2.9A)
None
None
None
None
ADP  A 500 (-4.3A)
 0.85A 3zosB-2f9gA:
21.4		 3zosB-2f9gA:
26.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gcd SERINE/THREONINE-PRO
TEIN KINASE TAO2

(Rattus
norvegicus) 		PF00069
(Pkinase) 		7 ALA A  55
GLU A  76
ILE A  89
LEU A 142
HIS A 149
ARG A 150
LEU A 158
 STU  A 400 (-3.2A)
None
STU  A 400 ( 4.5A)
None
None
SEP  A 181 ( 2.9A)
STU  A 400 ( 4.6A)
 0.67A 3zosB-2gcdA:
24.1		 3zosB-2gcdA:
28.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hk5 TYROSINE-PROTEIN
KINASE HCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 ALA A 271
LYS A 273
GLU A 288
THR A 316
HIS A 362
ARG A 363
LEU A 371
ALA A 381
 1BM  A 499 (-3.6A)
1BM  A 499 (-3.8A)
1BM  A 499 (-3.2A)
1BM  A 499 (-3.2A)
None
None
1BM  A 499 (-4.4A)
1BM  A 499 ( 3.7A)
 1.04A 3zosB-2hk5A:
23.5		 3zosB-2hk5A:
35.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 ALA A 269
GLU A 286
THR A 315
HIS A 361
ARG A 362
LEU A 370
ALA A 380
ASP A 381
 GIN  A 600 (-3.1A)
GIN  A 600 (-3.6A)
GIN  A 600 (-3.4A)
GIN  A 600 (-4.3A)
None
GIN  A 600 (-4.7A)
GIN  A 600 (-3.1A)
GIN  A 600 (-4.9A)
 1.02A 3zosB-2hz0A:
30.1		 3zosB-2hz0A:
38.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 ALA A 269
GLU A 286
THR A 315
HIS A 361
ARG A 362
LEU A 370
ASP A 381
PHE A 382
 GIN  A 600 (-3.1A)
GIN  A 600 (-3.6A)
GIN  A 600 (-3.4A)
GIN  A 600 (-4.3A)
None
GIN  A 600 (-4.7A)
GIN  A 600 (-4.9A)
GIN  A 600 (-4.0A)
 1.12A 3zosB-2hz0A:
30.1		 3zosB-2hz0A:
38.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 ALA A 269
GLU A 286
THR A 315
LEU A 354
HIS A 361
LEU A 370
ALA A 380
ASP A 381
 GIN  A 600 (-3.1A)
GIN  A 600 (-3.6A)
GIN  A 600 (-3.4A)
GIN  A 600 ( 4.6A)
GIN  A 600 (-4.3A)
GIN  A 600 (-4.7A)
GIN  A 600 (-3.1A)
GIN  A 600 (-4.9A)
 0.76A 3zosB-2hz0A:
30.1		 3zosB-2hz0A:
38.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 ALA A 269
LYS A 271
GLU A 286
THR A 315
HIS A 361
ARG A 362
LEU A 370
ALA A 380
 GIN  A 600 (-3.1A)
GIN  A 600 (-3.6A)
GIN  A 600 (-3.6A)
GIN  A 600 (-3.4A)
GIN  A 600 (-4.3A)
None
GIN  A 600 (-4.7A)
GIN  A 600 (-3.1A)
 0.98A 3zosB-2hz0A:
30.1		 3zosB-2hz0A:
38.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 ALA A 269
LYS A 271
GLU A 286
THR A 315
HIS A 361
ARG A 362
LEU A 370
PHE A 382
 GIN  A 600 (-3.1A)
GIN  A 600 (-3.6A)
GIN  A 600 (-3.6A)
GIN  A 600 (-3.4A)
GIN  A 600 (-4.3A)
None
GIN  A 600 (-4.7A)
GIN  A 600 (-4.0A)
 1.10A 3zosB-2hz0A:
30.1		 3zosB-2hz0A:
38.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 ALA A 269
LYS A 271
GLU A 286
THR A 315
LEU A 354
HIS A 361
LEU A 370
ALA A 380
 GIN  A 600 (-3.1A)
GIN  A 600 (-3.6A)
GIN  A 600 (-3.6A)
GIN  A 600 (-3.4A)
GIN  A 600 ( 4.6A)
GIN  A 600 (-4.3A)
GIN  A 600 (-4.7A)
GIN  A 600 (-3.1A)
 0.62A 3zosB-2hz0A:
30.1		 3zosB-2hz0A:
38.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2og8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 ALA A 271
LYS A 273
GLU A 288
THR A 316
HIS A 362
LEU A 371
ALA A 381
ASP A 382
PHE A 383
 1N8  A 501 ( 3.4A)
1N8  A 501 ( 3.4A)
1N8  A 501 ( 3.6A)
1N8  A 501 ( 3.3A)
None
1N8  A 501 ( 4.3A)
1N8  A 501 ( 3.3A)
1N8  A 501 ( 3.3A)
1N8  A 501 ( 4.3A)
 0.49A 3zosB-2og8A:
30.9		 3zosB-2og8A:
37.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2og8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 ALA A 271
THR A 316
HIS A 362
ARG A 363
LEU A 371
ALA A 381
ASP A 382
PHE A 383
 1N8  A 501 ( 3.4A)
1N8  A 501 ( 3.3A)
None
None
1N8  A 501 ( 4.3A)
1N8  A 501 ( 3.3A)
1N8  A 501 ( 3.3A)
1N8  A 501 ( 4.3A)
 0.66A 3zosB-2og8A:
30.9		 3zosB-2og8A:
37.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ogv MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
PRECURSOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 ALA A 614
LYS A 616
GLU A 633
THR A 663
HIS A 776
ARG A 777
LEU A 785
ASP A 796
 None
 1.07A 3zosB-2ogvA:
32.8		 3zosB-2ogvA:
35.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ogv MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
PRECURSOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 ALA A 614
LYS A 616
GLU A 633
THR A 663
LEU A 769
HIS A 776
LEU A 785
ASP A 796
 None
 0.88A 3zosB-2ogvA:
32.8		 3zosB-2ogvA:
35.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2p4i ANGIOPOIETIN-1
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 ALA A 853
ILE A 886
LEU A 955
HIS A 962
LEU A 971
ALA A 981
ASP A 982
PHE A 983
 MR9  A 301 (-3.5A)
MR9  A 301 (-4.0A)
MR9  A 301 (-4.4A)
MR9  A 301 (-4.5A)
MR9  A 301 (-4.5A)
MR9  A 301 (-3.2A)
MR9  A 301 (-4.2A)
MR9  A 301 (-4.4A)
 0.67A 3zosB-2p4iA:
12.2		 3zosB-2p4iA:
33.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2p4i ANGIOPOIETIN-1
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 853
LEU A 955
HIS A 962
ARG A 963
LEU A 971
ALA A 981
ASP A 982
 MR9  A 301 (-3.5A)
MR9  A 301 (-4.4A)
MR9  A 301 (-4.5A)
None
MR9  A 301 (-4.5A)
MR9  A 301 (-3.2A)
MR9  A 301 (-4.2A)
 0.78A 3zosB-2p4iA:
12.2		 3zosB-2p4iA:
33.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 515
GLU A 534
ILE A 548
LEU A 617
HIS A 624
LEU A 633
ALA A 643
 None
 0.72A 3zosB-2psqA:
23.7		 3zosB-2psqA:
33.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 515
LYS A 517
GLU A 534
ILE A 548
LEU A 617
HIS A 624
ALA A 643
 None
 0.83A 3zosB-2psqA:
23.7		 3zosB-2psqA:
33.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qlu ACTIVIN RECEPTOR
TYPE IIB

(Homo sapiens) 		PF00069
(Pkinase) 		8 ALA A 215
LYS A 217
GLU A 230
THR A 265
LEU A 301
HIS A 319
LEU A 328
ALA A 338
 ADE  A 488 (-3.2A)
None
None
ADE  A 488 (-4.3A)
None
None
ADE  A 488 (-4.4A)
None
 0.87A 3zosB-2qluA:
23.9		 3zosB-2qluA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qr7 RIBOSOMAL PROTEIN S6
KINASE ALPHA-3

(Mus musculus) 		PF00069
(Pkinase) 		7 ALA A 449
LYS A 451
GLU A 463
ILE A 477
THR A 493
LEU A 530
HIS A 537
 None
 0.71A 3zosB-2qr7A:
19.0		 3zosB-2qr7A:
24.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xik SERINE/THREONINE
PROTEIN KINASE 25

(Homo sapiens) 		PF00069
(Pkinase) 		7 ALA A  47
GLU A  66
LEU A 131
HIS A 138
ARG A 139
LEU A 147
ALA A 157
 J60  A1294 (-3.3A)
None
None
None
TPO  A 174 ( 2.9A)
J60  A1294 (-4.8A)
J60  A1294 ( 4.2A)
 0.76A 3zosB-2xikA:
17.9		 3zosB-2xikA:
24.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2xyu EPHRIN TYPE-A
RECEPTOR 4,

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		7 ALA A 651
ILE A 683
THR A 699
LEU A 737
HIS A 744
LEU A 753
ASP A 764
 Q9G  A1898 (-3.2A)
Q9G  A1898 ( 4.9A)
Q9G  A1898 (-3.5A)
None
None
Q9G  A1898 (-4.3A)
None
 0.77A 3zosB-2xyuA:
24.2		 3zosB-2xyuA:
35.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 ALA A 512
GLU A 531
ILE A 545
LEU A 614
HIS A 621
ARG A 622
LEU A 630
ALA A 640
PHE A 489
 C4F  A   1 (-3.3A)
None
C4F  A   1 ( 4.0A)
None
None
None
C4F  A   1 (-4.6A)
C4F  A   1 (-3.6A)
C4F  A   1 (-3.7A)
 0.87A 3zosB-3c4fA:
24.5		 3zosB-3c4fA:
37.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3d7u TYROSINE-PROTEIN
KINASE CSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 ALA A 220
LYS A 222
GLU A 236
THR A 266
LEU A 305
HIS A 312
ARG A 313
LEU A 321
 None
 0.64A 3zosB-3d7uA:
24.1		 3zosB-3d7uA:
32.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dko EPHRIN TYPE-A
RECEPTOR 7

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		7 ALA A 663
GLU A 682
LEU A 749
HIS A 756
LEU A 765
ASP A 776
PHE A 777
 IHZ  A1001 (-3.3A)
IHZ  A1001 (-3.8A)
None
IHZ  A1001 ( 4.9A)
IHZ  A1001 (-4.6A)
IHZ  A1001 (-4.8A)
IHZ  A1001 (-4.7A)
 0.77A 3zosB-3dkoA:
30.3		 3zosB-3dkoA:
34.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f2a PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1

(Homo sapiens) 		PF00069
(Pkinase) 		7 ALA A  65
LYS A  67
GLU A  89
ILE A 104
HIS A 165
ARG A 166
LEU A 174
 985  A   1 (-3.5A)
985  A   1 ( 2.8A)
MG  A 314 (-3.6A)
985  A   1 ( 4.7A)
None
None
985  A   1 (-4.8A)
 0.83A 3zosB-3f2aA:
15.6		 3zosB-3f2aA:
25.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gp0 MITOGEN-ACTIVATED
PROTEIN KINASE 11

(Homo sapiens) 		PF00069
(Pkinase) 		7 ALA A  51
LYS A  53
GLU A  71
ILE A  84
THR A 106
HIS A 148
ASP A 168
 NIL  A   1 (-3.7A)
None
NIL  A   1 (-3.7A)
NIL  A   1 (-4.4A)
NIL  A   1 (-3.3A)
NIL  A   1 (-4.3A)
NIL  A   1 (-4.6A)
 0.74A 3zosB-3gp0A:
22.0		 3zosB-3gp0A:
25.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 ALA A 859
LYS A 861
GLU A 878
LEU A1013
HIS A1020
ARG A1021
LEU A1029
ASP A1040
PHE A1041
 8ST  A2001 ( 3.8A)
8ST  A2001 (-4.0A)
8ST  A2001 (-3.7A)
8ST  A2001 (-4.6A)
8ST  A2001 ( 4.8A)
None
None
None
8ST  A2001 ( 3.7A)
 0.73A 3zosB-3hngA:
33.6		 3zosB-3hngA:
30.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kul EPHRIN TYPE-A
RECEPTOR 8

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		8 ALA A 665
LYS A 667
GLU A 684
ILE A 697
THR A 713
HIS A 758
ARG A 759
LEU A 767
 None
 1.03A 3zosB-3kulA:
24.5		 3zosB-3kulA:
37.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kul EPHRIN TYPE-A
RECEPTOR 8

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		8 ALA A 665
LYS A 667
GLU A 684
ILE A 697
THR A 713
LEU A 751
HIS A 758
LEU A 767
 None
 0.52A 3zosB-3kulA:
24.5		 3zosB-3kulA:
37.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lj0 SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A) 		8 ALA A 700
LYS A 702
GLU A 715
ILE A 729
LEU A 788
HIS A 795
ARG A 796
LEU A 804
 ADP  A2101 (-3.5A)
ADP  A2101 (-2.7A)
None
None
None
None
TPO  A 844 ( 3.0A)
ADP  A2101 (-4.4A)
 0.87A 3zosB-3lj0A:
20.8		 3zosB-3lj0A:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF08515
(TGF_beta_GS) 		9 ALA A 229
LYS A 231
GLU A 244
THR A 279
LEU A 315
HIS A 330
ARG A 331
LEU A 339
ALA A 349
 LDN  A   1 (-3.6A)
None
None
LDN  A   1 (-3.8A)
None
None
None
LDN  A   1 (-4.5A)
LDN  A   1 ( 3.8A)
 0.99A 3zosB-3mdyA:
24.0		 3zosB-3mdyA:
24.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mi9 CELL DIVISION
PROTEIN KINASE 9

(Homo sapiens) 		PF00069
(Pkinase) 		7 ALA A  46
LYS A  48
GLU A  66
HIS A 147
ARG A 148
LEU A 156
ALA A 166
 None
None
None
None
TPO  A 186 ( 2.8A)
None
None
 0.67A 3zosB-3mi9A:
22.0		 3zosB-3mi9A:
25.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 ALA A 227
LYS A 229
THR A 277
LEU A 313
HIS A 328
ARG A 329
LEU A 337
ALA A 347
 LDN  A 600 (-3.2A)
LDN  A 600 (-4.0A)
LDN  A 600 (-4.0A)
None
None
None
LDN  A 600 (-4.6A)
LDN  A 600 ( 3.8A)
 0.98A 3zosB-3my0A:
23.9		 3zosB-3my0A:
27.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 227
THR A 277
LEU A 313
HIS A 328
LEU A 337
ALA A 347
ASP A 348
 LDN  A 600 (-3.2A)
LDN  A 600 (-4.0A)
None
None
LDN  A 600 (-4.6A)
LDN  A 600 ( 3.8A)
None
 0.86A 3zosB-3my0A:
23.9		 3zosB-3my0A:
27.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1

(Arabidopsis
thaliana) 		PF07714
(Pkinase_Tyr) 		7 ALA A 576
LYS A 578
GLU A 596
THR A 625
LEU A 665
HIS A 674
LEU A 683
 STU  A   1 (-3.3A)
STU  A   1 (-3.5A)
None
STU  A   1 (-4.1A)
None
None
STU  A   1 (-4.3A)
 0.61A 3zosB-3ppzA:
27.4		 3zosB-3ppzA:
31.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q4t ACTIVIN RECEPTOR
TYPE-2A

(Homo sapiens) 		PF00069
(Pkinase) 		8 ALA A 217
LYS A 219
GLU A 232
LEU A 303
HIS A 320
ARG A 321
LEU A 329
ALA A 339
 TAK  A   2 (-3.5A)
TAK  A   2 (-2.9A)
TAK  A   2 ( 4.9A)
None
None
None
TAK  A   2 (-4.6A)
TAK  A   2 ( 4.2A)
 1.20A 3zosB-3q4tA:
23.1		 3zosB-3q4tA:
26.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q4t ACTIVIN RECEPTOR
TYPE-2A

(Homo sapiens) 		PF00069
(Pkinase) 		8 ALA A 217
LYS A 219
THR A 267
LEU A 303
HIS A 320
ARG A 321
LEU A 329
ALA A 339
 TAK  A   2 (-3.5A)
TAK  A   2 (-2.9A)
TAK  A   2 (-3.5A)
None
None
None
TAK  A   2 (-4.6A)
TAK  A   2 ( 4.2A)
 1.02A 3zosB-3q4tA:
23.1		 3zosB-3q4tA:
26.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q5i PROTEIN KINASE

(Plasmodium
berghei) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		9 ALA A  84
LYS A  86
GLU A 115
ILE A 128
THR A 144
LEU A 181
HIS A 188
ARG A 189
LEU A 197
 ANP  A1634 (-3.6A)
ANP  A1634 (-3.1A)
None
None
ANP  A1634 (-4.6A)
None
None
None
ANP  A1634 (-4.4A)
 0.79A 3zosB-3q5iA:
20.7		 3zosB-3q5iA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s95 LIM DOMAIN KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LYS A 368
GLU A 384
THR A 413
LEU A 451
HIS A 458
ARG A 459
LEU A 467
ALA A 477
 STU  A   1 (-3.1A)
STU  A   1 (-3.7A)
STU  A   1 (-3.9A)
None
None
None
STU  A   1 (-4.6A)
STU  A   1 ( 4.1A)
 1.01A 3zosB-3s95A:
24.2		 3zosB-3s95A:
29.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3tt0 BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 ALA A 512
LYS A 514
GLU A 531
ILE A 545
LEU A 614
HIS A 621
LEU A 630
ALA A 640
 07J  A   1 (-3.5A)
07J  A   1 (-4.5A)
07J  A   1 (-3.8A)
07J  A   1 (-3.8A)
None
None
07J  A   1 ( 4.4A)
07J  A   1 (-3.2A)
 0.68A 3zosB-3tt0A:
30.4		 3zosB-3tt0A:
31.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 866
GLU A 885
LEU A1019
HIS A1026
ARG A1027
LEU A1035
ASP A1046
 4TT  A2001 (-3.5A)
None
None
None
None
4TT  A2001 (-4.8A)
None
 0.72A 3zosB-3vidA:
30.3		 3zosB-3vidA:
31.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zfx EPHRIN TYPE-B
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 ALA A 649
LYS A 651
GLU A 668
ILE A 681
THR A 697
LEU A 735
HIS A 742
ARG A 743
 None
 0.92A 3zosB-3zfxA:
30.5		 3zosB-3zfxA:
37.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zfx EPHRIN TYPE-B
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 ALA A 649
LYS A 651
ILE A 681
THR A 697
LEU A 735
HIS A 742
ARG A 743
LEU A 751
 None
 0.84A 3zosB-3zfxA:
30.5		 3zosB-3zfxA:
37.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 ALA A 866
LYS A 868
GLU A 885
HIS A1026
ARG A1027
LEU A1035
ASP A1046
PHE A1047
 B49  A2000 (-3.5A)
B49  A2000 (-3.0A)
None
None
None
B49  A2000 (-4.5A)
None
B49  A2000 (-4.0A)
 1.11A 3zosB-4agdA:
33.5		 3zosB-4agdA:
30.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 ALA A 866
LYS A 868
GLU A 885
LEU A1019
HIS A1026
LEU A1035
ASP A1046
PHE A1047
 B49  A2000 (-3.5A)
B49  A2000 (-3.0A)
None
None
None
B49  A2000 (-4.5A)
None
B49  A2000 (-4.0A)
 0.89A 3zosB-4agdA:
33.5		 3zosB-4agdA:
30.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aw2 SERINE/THREONINE-PRO
TEIN KINASE MRCK
ALPHA

(Rattus
norvegicus) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		7 ALA A 104
LYS A 106
GLU A 125
HIS A 199
ARG A 200
LEU A 208
ALA A 218
 EDO  A1420 (-3.4A)
EDO  A1419 (-3.3A)
EDO  A1419 (-3.0A)
None
None
EDO  A1420 ( 4.8A)
None
 0.85A 3zosB-4aw2A:
20.0		 3zosB-4aw2A:
25.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c02 ACTIVIN RECEPTOR
TYPE-1

(Homo sapiens) 		PF00069
(Pkinase)
PF08515
(TGF_beta_GS) 		7 ALA A 233
LYS A 235
THR A 283
LEU A 319
HIS A 334
LEU A 343
ALA A 353
 TAK  A1507 (-3.3A)
TAK  A1507 ( 4.5A)
TAK  A1507 (-3.6A)
None
None
TAK  A1507 (-4.7A)
TAK  A1507 ( 4.2A)
 0.78A 3zosB-4c02A:
23.9		 3zosB-4c02A:
28.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ckr EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		10 ALA A 653
GLU A 672
ILE A 685
THR A 701
LEU A 757
HIS A 764
LEU A 773
ALA A 783
ASP A 784
PHE A 785
 DI1  A1000 (-3.6A)
DI1  A1000 (-3.8A)
DI1  A1000 (-4.5A)
DI1  A1000 (-3.6A)
DI1  A1000 (-4.4A)
DI1  A1000 (-3.8A)
DI1  A1000 (-4.5A)
DI1  A1000 (-3.7A)
DI1  A1000 (-4.1A)
DI1  A1000 (-4.5A)
 0.51A 3zosB-4ckrA:
43.7		 3zosB-4ckrA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ckr EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 653
HIS A 764
ARG A 765
LEU A 773
ALA A 783
ASP A 784
PHE A 785
 DI1  A1000 (-3.6A)
DI1  A1000 (-3.8A)
None
DI1  A1000 (-4.5A)
DI1  A1000 (-3.7A)
DI1  A1000 (-4.1A)
DI1  A1000 (-4.5A)
 0.82A 3zosB-4ckrA:
43.7		 3zosB-4ckrA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ckr EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		10 ALA A 653
LYS A 655
GLU A 672
ILE A 685
THR A 701
LEU A 757
HIS A 764
LEU A 773
ALA A 783
ASP A 784
 DI1  A1000 (-3.6A)
DI1  A1000 (-3.9A)
DI1  A1000 (-3.8A)
DI1  A1000 (-4.5A)
DI1  A1000 (-3.6A)
DI1  A1000 (-4.4A)
DI1  A1000 (-3.8A)
DI1  A1000 (-4.5A)
DI1  A1000 (-3.7A)
DI1  A1000 (-4.1A)
 0.46A 3zosB-4ckrA:
43.7		 3zosB-4ckrA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ckr EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 653
LYS A 655
HIS A 764
ARG A 765
LEU A 773
ALA A 783
ASP A 784
 DI1  A1000 (-3.6A)
DI1  A1000 (-3.9A)
DI1  A1000 (-3.8A)
None
DI1  A1000 (-4.5A)
DI1  A1000 (-3.7A)
DI1  A1000 (-4.1A)
 0.85A 3zosB-4ckrA:
43.7		 3zosB-4ckrA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4crs SERINE/THREONINE-PRO
TEIN KINASE N2

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		7 ALA A 684
LYS A 686
GLU A 705
LEU A 773
ARG A 781
LEU A 789
ALA A 799
 AGS  A1985 (-3.5A)
AGS  A1985 (-3.0A)
None
None
TPO  A 816 ( 3.0A)
AGS  A1985 (-4.8A)
AGS  A1985 ( 4.5A)
 0.79A 3zosB-4crsA:
20.7		 3zosB-4crsA:
24.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ez5 CYCLIN-DEPENDENT
KINASE 6

(Homo sapiens) 		PF00069
(Pkinase) 		7 ALA A  41
LYS A  43
LEU A 136
HIS A 143
ARG A 144
LEU A 152
ALA A 162
 0RS  A 900 ( 3.7A)
0RS  A 900 (-3.3A)
None
None
None
0RS  A 900 (-4.3A)
0RS  A 900 (-3.6A)
 0.75A 3zosB-4ez5A:
21.5		 3zosB-4ez5A:
28.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hvi TYROSINE-PROTEIN
KINASE JAK3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 ALA A 853
LYS A 855
GLU A 871
HIS A 947
ARG A 948
LEU A 956
ALA A 966
ASP A 967
 19S  A1201 (-3.3A)
19S  A1201 (-3.5A)
None
None
None
19S  A1201 (-4.5A)
19S  A1201 ( 4.1A)
19S  A1201 ( 4.1A)
 1.29A 3zosB-4hviA:
29.2		 3zosB-4hviA:
33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hvi TYROSINE-PROTEIN
KINASE JAK3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 853
LYS A 855
GLU A 871
LEU A 940
HIS A 947
LEU A 956
ALA A 966
 19S  A1201 (-3.3A)
19S  A1201 (-3.5A)
None
None
None
19S  A1201 (-4.5A)
19S  A1201 ( 4.1A)
 0.54A 3zosB-4hviA:
29.2		 3zosB-4hviA:
33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4k33 FIBROBLAST GROWTH
FACTOR RECEPTOR 3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 ALA A 506
LYS A 508
GLU A 525
ILE A 539
LEU A 608
HIS A 615
ARG A 616
LEU A 624
ALA A 634
 ACP  A 801 (-3.3A)
ACP  A 801 (-2.7A)
ACP  A 801 ( 4.8A)
None
None
None
None
ACP  A 801 (-4.4A)
None
 1.01A 3zosB-4k33A:
6.3		 3zosB-4k33A:
34.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m69 RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 3

(Mus musculus) 		PF00069
(Pkinase) 		7 ALA A  49
LYS A  51
THR A  95
LEU A 132
HIS A 141
LEU A 150
ALA A 160
 ANP  A 401 (-3.1A)
ANP  A 401 (-2.9A)
ANP  A 401 (-3.8A)
None
None
ANP  A 401 (-4.8A)
None
 0.80A 3zosB-4m69A:
22.1		 3zosB-4m69A:
27.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o27 SERINE/THREONINE-PRO
TEIN KINASE 24

(Homo sapiens) 		PF00069
(Pkinase) 		8 ALA B  51
LYS B  53
GLU B  70
LEU B 135
HIS B 142
ARG B 143
LEU B 151
ALA B 161
 ADP  B 500 (-3.3A)
ADP  B 500 (-3.1A)
None
None
None
None
ADP  B 500 (-4.7A)
None
 0.78A 3zosB-4o27B:
23.9		 3zosB-4o27B:
26.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o38 CYCLIN-G-ASSOCIATED
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		7 ALA A  67
LYS A  69
GLU A  85
THR A 123
HIS A 171
ARG A 172
LEU A 180
 SIN  A 401 ( 3.7A)
None
None
None
None
None
SIN  A 401 ( 4.5A)
 0.77A 3zosB-4o38A:
20.0		 3zosB-4o38A:
25.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 ALA A 642
LYS A 644
GLU A 661
LEU A 802
HIS A 809
ARG A 810
LEU A 818
ASP A 829
PHE A 830
 P30  A1001 (-3.4A)
P30  A1001 (-3.4A)
P30  A1001 (-3.6A)
None
P30  A1001 ( 4.3A)
None
P30  A1001 (-4.6A)
None
P30  A1001 (-3.9A)
 0.76A 3zosB-4rt7A:
27.5		 3zosB-4rt7A:
28.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tpt LIM DOMAIN KINASE 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 THR A 405
LEU A 442
HIS A 449
ARG A 450
LEU A 458
ALA A 468
ASP A 469
PHE A 470
 35H  A 701 (-3.8A)
35H  A 701 ( 4.7A)
35H  A 701 ( 4.4A)
None
None
35H  A 701 (-3.5A)
35H  A 701 (-4.7A)
35H  A 701 (-4.4A)
 1.11A 3zosB-4tptA:
20.4		 3zosB-4tptA:
29.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL

(synthetic
construct) 		PF07714
(Pkinase_Tyr) 		8 ALA A  35
LYS A  37
GLU A  52
THR A  81
HIS A 127
LEU A 136
ALA A 146
ASP A 147
 ACP  A1264 (-2.9A)
None
None
ACP  A1264 (-4.5A)
None
ACP  A1264 ( 4.8A)
None
None
 0.94A 3zosB-4ueuA:
30.1		 3zosB-4ueuA:
39.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uy9 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 9

(Homo sapiens) 		PF00069
(Pkinase) 		7 ALA A 169
LYS A 171
ILE A 204
LEU A 256
HIS A 266
ARG A 267
LEU A 275
 None
 0.78A 3zosB-4uy9A:
25.9		 3zosB-4uy9A:
29.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xbr PROTEIN
FAM212A,SERINE/THREO
NINE-PROTEIN KINASE
PAK 4

(Homo sapiens) 		PF00069
(Pkinase)
PF15342
(FAM212) 		7 ALA A 348
LYS A 350
GLU A 366
LEU A 431
HIS A 438
ARG A 439
LEU A 447
 ATP  A 601 ( 3.7A)
ATP  A 601 (-2.8A)
ATP  A 601 ( 3.7A)
None
None
SEP  A 474 ( 3.2A)
None
 0.82A 3zosB-4xbrA:
15.3		 3zosB-4xbrA:
23.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xcu FIBROBLAST GROWTH
FACTOR RECEPTOR 4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 501
GLU A 520
ILE A 534
LEU A 603
HIS A 610
LEU A 619
ALA A 629
 40M  A1002 ( 4.1A)
40M  A1002 (-3.7A)
40M  A1002 (-4.0A)
None
None
40M  A1002 (-4.5A)
40M  A1002 (-3.0A)
 0.56A 3zosB-4xcuA:
29.5		 3zosB-4xcuA:
38.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xcu FIBROBLAST GROWTH
FACTOR RECEPTOR 4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 501
LYS A 503
GLU A 520
ILE A 534
HIS A 610
LEU A 619
ALA A 629
 40M  A1002 ( 4.1A)
40M  A1002 (-4.0A)
40M  A1002 (-3.7A)
40M  A1002 (-4.0A)
None
40M  A1002 (-4.5A)
40M  A1002 (-3.0A)
 0.71A 3zosB-4xcuA:
29.5		 3zosB-4xcuA:
38.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 642
GLU A 661
LEU A 802
HIS A 809
LEU A 818
ASP A 829
PHE A 830
 P30  A1001 (-3.5A)
P30  A1001 (-3.1A)
None
P30  A1001 (-4.4A)
P30  A1001 (-4.3A)
None
P30  A1001 ( 4.1A)
 0.61A 3zosB-4xufA:
26.4		 3zosB-4xufA:
33.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 ALA A 642
LYS A 644
GLU A 661
HIS A 809
ARG A 810
LEU A 818
ASP A 829
PHE A 830
 P30  A1001 (-3.5A)
P30  A1001 ( 4.0A)
P30  A1001 (-3.1A)
P30  A1001 (-4.4A)
None
P30  A1001 (-4.3A)
None
P30  A1001 ( 4.1A)
 1.10A 3zosB-4xufA:
26.4		 3zosB-4xufA:
33.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE

(Bos taurus) 		PF00169
(PH)
PF00779
(BTK)
PF07714
(Pkinase_Tyr) 		7 ALA A 428
LYS A 430
THR A 474
LEU A 512
HIS A 519
ARG A 520
LEU A 528
 746  A 702 (-2.4A)
746  A 702 (-3.7A)
746  A 702 (-3.7A)
None
None
None
746  A 702 (-4.4A)
 0.77A 3zosB-4y93A:
29.4		 3zosB-4y93A:
24.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yff SERINE/THREONINE-PRO
TEIN KINASE TNNI3K

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 ALA A 488
LYS A 490
GLU A 509
ILE A 522
LEU A 577
HIS A 586
LEU A 595
ALA A 605
 4CV  A 801 (-3.5A)
4CV  A 801 (-3.9A)
None
4CV  A 801 ( 4.2A)
None
None
4CV  A 801 (-4.4A)
4CV  A 801 ( 3.9A)
 0.77A 3zosB-4yffA:
24.3		 3zosB-4yffA:
29.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yff SERINE/THREONINE-PRO
TEIN KINASE TNNI3K

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 ALA A 488
LYS A 490
GLU A 509
ILE A 522
THR A 539
LEU A 577
LEU A 595
ALA A 605
 4CV  A 801 (-3.5A)
4CV  A 801 (-3.9A)
None
4CV  A 801 ( 4.2A)
4CV  A 801 (-2.8A)
None
4CV  A 801 (-4.4A)
4CV  A 801 ( 3.9A)
 0.67A 3zosB-4yffA:
24.3		 3zosB-4yffA:
29.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE

(Eimeria tenella) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		7 ALA A  55
LYS A  57
GLU A  76
THR A 105
HIS A 149
ARG A 150
LEU A 158
 ADP  A 506 (-3.3A)
ADP  A 506 (-2.4A)
None
ADP  A 506 ( 4.6A)
None
None
ADP  A 506 (-4.7A)
 0.82A 3zosB-4ysjA:
22.5		 3zosB-4ysjA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z7g SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1

(Homo sapiens) 		PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A) 		7 ALA A 597
LYS A 599
GLU A 612
ILE A 626
LEU A 679
HIS A 686
LEU A 695
 None
 0.84A 3zosB-4z7gA:
19.0		 3zosB-4z7gA:
22.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 ALA A 512
LYS A 514
GLU A 531
ILE A 545
LEU A 614
HIS A 621
ARG A 622
LEU A 630
ALA A 640
 38O  A1769 (-3.6A)
38O  A1769 ( 3.1A)
EDO  A1766 (-4.1A)
38O  A1769 ( 3.3A)
None
None
None
38O  A1769 (-4.6A)
EDO  A1766 ( 4.4A)
 0.64A 3zosB-5a46A:
30.7		 3zosB-5a46A:
31.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e8y TGF-BETA RECEPTOR
TYPE-2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 ALA A 275
LYS A 277
GLU A 290
THR A 325
LEU A 361
HIS A 377
ARG A 378
LEU A 386
 STU  A 601 (-3.1A)
STU  A 601 (-2.4A)
STU  A 601 ( 3.8A)
STU  A 601 ( 3.7A)
None
None
None
STU  A 601 (-3.9A)
 0.79A 3zosB-5e8yA:
23.8		 3zosB-5e8yA:
26.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 ALA A 928
LYS A 930
GLU A 947
ILE A 960
LEU A1014
HIS A1021
ARG A1022
LEU A1030
 5U3  A1200 (-3.5A)
None
None
5U3  A1200 (-4.6A)
None
None
None
5U3  A1200 (-4.4A)
 1.19A 3zosB-5f1zA:
27.1		 3zosB-5f1zA:
34.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 ALA A 625
LYS A 627
GLU A 644
THR A 674
LEU A 809
HIS A 816
LEU A 825
ASP A 836
PHE A 837
 748  A1001 (-3.7A)
748  A1001 (-4.0A)
748  A1001 (-3.3A)
748  A1001 (-3.2A)
748  A1001 ( 4.6A)
748  A1001 (-3.8A)
748  A1001 (-4.3A)
748  A1001 (-4.8A)
748  A1001 (-3.7A)
 0.58A 3zosB-5grnA:
28.1		 3zosB-5grnA:
30.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5idn CYCLIN-DEPENDENT
KINASE 8

(Homo sapiens) 		PF00069
(Pkinase) 		7 ALA A  50
LYS A  52
GLU A  66
ILE A  79
LEU A 142
HIS A 149
ARG A 150
 6A7  A 401 (-3.3A)
6A7  A 401 ( 2.9A)
FMT  A 404 ( 4.2A)
6A7  A 401 (-4.2A)
None
FMT  A 403 (-4.6A)
None
 0.83A 3zosB-5idnA:
20.5		 3zosB-5idnA:
26.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5idn CYCLIN-DEPENDENT
KINASE 8

(Homo sapiens) 		PF00069
(Pkinase) 		7 ALA A  50
LYS A  52
ILE A  79
HIS A 149
LEU A 158
ALA A 172
ASP A 173
 6A7  A 401 (-3.3A)
6A7  A 401 ( 2.9A)
6A7  A 401 (-4.2A)
FMT  A 403 (-4.6A)
6A7  A 401 (-4.8A)
6A7  A 401 ( 4.1A)
FMT  A 403 ( 3.3A)
 0.74A 3zosB-5idnA:
20.5		 3zosB-5idnA:
26.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5idn CYCLIN-DEPENDENT
KINASE 8

(Homo sapiens) 		PF00069
(Pkinase) 		8 ALA A  50
LYS A  52
ILE A  79
LEU A 142
HIS A 149
ARG A 150
LEU A 158
ALA A 172
 6A7  A 401 (-3.3A)
6A7  A 401 ( 2.9A)
6A7  A 401 (-4.2A)
None
FMT  A 403 (-4.6A)
None
6A7  A 401 (-4.8A)
6A7  A 401 ( 4.1A)
 0.64A 3zosB-5idnA:
20.5		 3zosB-5idnA:
26.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3

(Homo sapiens) 		PF00069
(Pkinase) 		7 ALA A  43
LYS A  45
GLU A  61
LEU A 127
HIS A 134
LEU A 143
ALA A 153
 6G2  A 901 (-3.2A)
6G2  A 901 ( 3.9A)
None
None
None
6G2  A 901 (-4.7A)
6G2  A 901 ( 4.2A)
 0.67A 3zosB-5j5tA:
20.9		 3zosB-5j5tA:
23.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5l6o EPHRIN TYPE-B
RECEPTOR 3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 663
ILE A 695
THR A 711
LEU A 749
HIS A 756
LEU A 765
ASP A 776
 6P6  A1001 (-3.3A)
None
6P6  A1001 (-3.5A)
None
DIO  A1002 (-4.1A)
6P6  A1001 (-4.5A)
None
 0.42A 3zosB-5l6oA:
31.9		 3zosB-5l6oA:
37.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5l6o EPHRIN TYPE-B
RECEPTOR 3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ILE A 695
THR A 711
LEU A 749
HIS A 756
ARG A 757
LEU A 765
ASP A 776
 None
6P6  A1001 (-3.5A)
None
DIO  A1002 (-4.1A)
None
6P6  A1001 (-4.5A)
None
 0.73A 3zosB-5l6oA:
31.9		 3zosB-5l6oA:
37.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5myv SRSF PROTEIN KINASE
2,SRSF PROTEIN
KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		7 ALA A 119
LYS A 121
GLU A 136
LEU A 215
HIS A 223
LEU A 232
ALA A 540
 W4A  A 716 ( 3.9A)
SO4  A 702 (-3.3A)
DMS  A 717 (-4.0A)
None
None
None
DMS  A 717 ( 4.5A)
 0.83A 3zosB-5myvA:
12.7		 3zosB-5myvA:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vil MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 5

(Homo sapiens) 		no annotation 7 ALA A 707
LYS A 709
GLU A 725
LEU A 794
HIS A 801
ARG A 802
LEU A 810
 9E1  A1001 (-3.5A)
9E1  A1001 (-2.8A)
None
None
None
None
9E1  A1001 (-4.5A)
 0.77A 3zosB-5vilA:
18.2		 3zosB-5vilA:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xv7 SERINE-ARGININE (SR)
PROTEIN KINASE 1

(Homo sapiens) 		no annotation 7 ALA A 107
LYS A 109
GLU A 124
LEU A 203
HIS A 211
LEU A 220
ALA A 496
 EMH  A 705 (-3.6A)
EMH  A 705 ( 4.8A)
None
None
None
None
EMH  A 705 ( 4.0A)
 0.80A 3zosB-5xv7A:
20.3		 3zosB-5xv7A:
11.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y86 DUAL SPECIFICITY
TYROSINE-PHOSPHORYLA
TION-REGULATED
KINASE 3

(Homo sapiens) 		no annotation 7 ALA A 236
LYS A 238
GLU A 253
ILE A 272
LEU A 326
HIS A 333
LEU A 342
 HRM  A 601 (-3.5A)
HRM  A 601 (-3.3A)
HRM  A 601 ( 4.6A)
HRM  A 601 ( 4.8A)
None
None
None
 0.74A 3zosB-5y86A:
14.4		 3zosB-5y86A:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b3e CYCLIN-DEPENDENT
KINASE 12

(Homo sapiens) 		no annotation 7 ALA A 754
LYS A 756
GLU A 774
HIS A 857
ARG A 858
LEU A 866
ALA A 876
 CJM  A1102 (-3.1A)
None
None
None
TPO  A 893 ( 3.0A)
CJM  A1102 (-4.4A)
CJM  A1102 (-3.6A)
 0.74A 3zosB-6b3eA:
22.3		 3zosB-6b3eA:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cnh SERINE/THREONINE-PRO
TEIN KINASE PRP4
HOMOLOG

(Homo sapiens) 		no annotation 7 ALA A 715
GLU A 732
LEU A 806
HIS A 813
LEU A 822
ASP A 834
PHE A 835
 919  A1101 (-3.5A)
919  A1101 (-3.7A)
None
919  A1101 (-4.2A)
None
919  A1101 (-4.5A)
919  A1101 ( 4.1A)
 0.69A 3zosB-6cnhA:
2.3		 3zosB-6cnhA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cz4 PROTEIN-TYROSINE
KINASE 6

(Homo sapiens) 		no annotation 7 ALA A 217
THR A 264
LEU A 303
HIS A 310
ARG A 311
LEU A 319
ASP A 330
 FKY  A9001 (-3.3A)
FKY  A9001 (-3.0A)
FKY  A9001 (-4.4A)
FKY  A9001 (-3.9A)
None
FKY  A9001 ( 4.9A)
None
 0.83A 3zosB-6cz4A:
27.7		 3zosB-6cz4A:
14.43