SIMILAR PATTERNS OF AMINO ACIDS FOR 3ZOS_B_0LIB1000

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k9a CARBOXYL-TERMINAL
SRC KINASE

(Rattus
norvegicus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		8 ALA A 220
LYS A 222
GLU A 236
THR A 266
LEU A 305
HIS A 312
ARG A 313
LEU A 321
 None
 0.63A 3zosB-1k9aA:
28.5		 3zosB-1k9aA:
25.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1luf MUSCLE-SPECIFIC
TYROSINE KINASE
RECEPTOR MUSK

(Rattus
norvegicus) 		PF07714
(Pkinase_Tyr) 		7 ALA A 606
LYS A 608
LEU A 715
HIS A 722
LEU A 731
ALA A 741
ASP A 742
 None
 0.73A 3zosB-1lufA:
35.7		 3zosB-1lufA:
39.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		9 ALA A 288
LYS A 290
GLU A 305
THR A 334
LEU A 373
HIS A 380
ARG A 381
LEU A 389
ALA A 399
 P16  A   2 (-3.4A)
P16  A   2 (-4.5A)
P16  A   2 (-4.2A)
P16  A   2 (-3.7A)
None
None
None
P16  A   2 (-4.4A)
P16  A   2 (-3.5A)
 0.92A 3zosB-1opkA:
29.4		 3zosB-1opkA:
26.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1py5 TGF-BETA RECEPTOR
TYPE I

(Homo sapiens) 		PF00069
(Pkinase)
PF08515
(TGF_beta_GS) 		8 ALA A 230
LYS A 232
GLU A 245
LEU A 316
HIS A 331
ARG A 332
LEU A 340
ALA A 350
 PY1  A 700 (-3.5A)
PY1  A 700 (-3.9A)
PY1  A 700 ( 4.9A)
None
None
None
PY1  A 700 (-4.4A)
PY1  A 700 ( 4.2A)
 0.79A 3zosB-1py5A:
24.2		 3zosB-1py5A:
25.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1rjb FL CYTOKINE RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 642
LYS A 644
GLU A 661
LEU A 802
HIS A 809
LEU A 818
ASP A 829
 None
 0.72A 3zosB-1rjbA:
33.0		 3zosB-1rjbA:
32.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 ALA A 621
LYS A 623
GLU A 640
THR A 670
LEU A 783
HIS A 790
LEU A 799
ASP A 810
PHE A 811
 STI  A   3 (-3.5A)
STI  A   3 (-3.7A)
STI  A   3 (-3.6A)
STI  A   3 (-3.2A)
None
STI  A   3 (-4.5A)
STI  A   3 (-4.4A)
STI  A   3 (-3.9A)
STI  A   3 (-3.6A)
 0.61A 3zosB-1t46A:
34.9		 3zosB-1t46A:
32.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 ALA A 621
LYS A 623
THR A 670
LEU A 783
HIS A 790
ARG A 791
LEU A 799
ASP A 810
PHE A 811
 STI  A   3 (-3.5A)
STI  A   3 (-3.7A)
STI  A   3 (-3.2A)
None
STI  A   3 (-4.5A)
None
STI  A   3 (-4.4A)
STI  A   3 (-3.9A)
STI  A   3 (-3.6A)
 0.75A 3zosB-1t46A:
34.9		 3zosB-1t46A:
32.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u5q SERINE/THREONINE
PROTEIN KINASE TAO2

(Rattus
norvegicus) 		PF00069
(Pkinase) 		8 ALA A  55
LYS A  57
GLU A  76
ILE A  89
LEU A 142
HIS A 149
ARG A 150
LEU A 158
 None
None
None
None
None
None
SEP  A 181 ( 2.8A)
None
 0.77A 3zosB-1u5qA:
23.2		 3zosB-1u5qA:
26.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1

(Homo sapiens) 		PF00069
(Pkinase) 		7 ALA A  36
LYS A  38
GLU A  55
LEU A 121
HIS A 128
ARG A 129
LEU A 137
 HYM  A 400 (-3.5A)
HYM  A 400 (-3.2A)
None
None
None
SO4  A 901 (-2.9A)
HYM  A 400 (-4.5A)
 0.79A 3zosB-1zltA:
20.3		 3zosB-1zltA:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eu9 DUAL SPECIFICITY
PROTEIN KINASE CLK3

(Homo sapiens) 		PF00069
(Pkinase) 		7 ALA A 184
LYS A 186
GLU A 201
LEU A 274
HIS A 281
LEU A 290
ALA A 319
 None
 0.71A 3zosB-2eu9A:
20.9		 3zosB-2eu9A:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f9g MITOGEN-ACTIVATED
PROTEIN KINASE FUS3

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		7 ALA A  40
LYS A  42
GLU A  59
ILE A  72
LEU A 128
HIS A 135
LEU A 144
 ADP  A 500 ( 3.7A)
ADP  A 500 (-2.9A)
None
None
None
None
ADP  A 500 (-4.3A)
 0.85A 3zosB-2f9gA:
21.4		 3zosB-2f9gA:
26.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gcd SERINE/THREONINE-PRO
TEIN KINASE TAO2

(Rattus
norvegicus) 		PF00069
(Pkinase) 		7 ALA A  55
GLU A  76
ILE A  89
LEU A 142
HIS A 149
ARG A 150
LEU A 158
 STU  A 400 (-3.2A)
None
STU  A 400 ( 4.5A)
None
None
SEP  A 181 ( 2.9A)
STU  A 400 ( 4.6A)
 0.67A 3zosB-2gcdA:
24.1		 3zosB-2gcdA:
28.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hk5 TYROSINE-PROTEIN
KINASE HCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 ALA A 271
LYS A 273
GLU A 288
THR A 316
HIS A 362
ARG A 363
LEU A 371
ALA A 381
 1BM  A 499 (-3.6A)
1BM  A 499 (-3.8A)
1BM  A 499 (-3.2A)
1BM  A 499 (-3.2A)
None
None
1BM  A 499 (-4.4A)
1BM  A 499 ( 3.7A)
 1.04A 3zosB-2hk5A:
23.5		 3zosB-2hk5A:
35.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 ALA A 269
GLU A 286
THR A 315
HIS A 361
ARG A 362
LEU A 370
ALA A 380
ASP A 381
 GIN  A 600 (-3.1A)
GIN  A 600 (-3.6A)
GIN  A 600 (-3.4A)
GIN  A 600 (-4.3A)
None
GIN  A 600 (-4.7A)
GIN  A 600 (-3.1A)
GIN  A 600 (-4.9A)
 1.02A 3zosB-2hz0A:
30.1		 3zosB-2hz0A:
38.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 ALA A 269
GLU A 286
THR A 315
HIS A 361
ARG A 362
LEU A 370
ASP A 381
PHE A 382
 GIN  A 600 (-3.1A)
GIN  A 600 (-3.6A)
GIN  A 600 (-3.4A)
GIN  A 600 (-4.3A)
None
GIN  A 600 (-4.7A)
GIN  A 600 (-4.9A)
GIN  A 600 (-4.0A)
 1.12A 3zosB-2hz0A:
30.1		 3zosB-2hz0A:
38.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 ALA A 269
GLU A 286
THR A 315
LEU A 354
HIS A 361
LEU A 370
ALA A 380
ASP A 381
 GIN  A 600 (-3.1A)
GIN  A 600 (-3.6A)
GIN  A 600 (-3.4A)
GIN  A 600 ( 4.6A)
GIN  A 600 (-4.3A)
GIN  A 600 (-4.7A)
GIN  A 600 (-3.1A)
GIN  A 600 (-4.9A)
 0.76A 3zosB-2hz0A:
30.1		 3zosB-2hz0A:
38.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 ALA A 269
LYS A 271
GLU A 286
THR A 315
HIS A 361
ARG A 362
LEU A 370
ALA A 380
 GIN  A 600 (-3.1A)
GIN  A 600 (-3.6A)
GIN  A 600 (-3.6A)
GIN  A 600 (-3.4A)
GIN  A 600 (-4.3A)
None
GIN  A 600 (-4.7A)
GIN  A 600 (-3.1A)
 0.98A 3zosB-2hz0A:
30.1		 3zosB-2hz0A:
38.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 ALA A 269
LYS A 271
GLU A 286
THR A 315
HIS A 361
ARG A 362
LEU A 370
PHE A 382
 GIN  A 600 (-3.1A)
GIN  A 600 (-3.6A)
GIN  A 600 (-3.6A)
GIN  A 600 (-3.4A)
GIN  A 600 (-4.3A)
None
GIN  A 600 (-4.7A)
GIN  A 600 (-4.0A)
 1.10A 3zosB-2hz0A:
30.1		 3zosB-2hz0A:
38.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 ALA A 269
LYS A 271
GLU A 286
THR A 315
LEU A 354
HIS A 361
LEU A 370
ALA A 380
 GIN  A 600 (-3.1A)
GIN  A 600 (-3.6A)
GIN  A 600 (-3.6A)
GIN  A 600 (-3.4A)
GIN  A 600 ( 4.6A)
GIN  A 600 (-4.3A)
GIN  A 600 (-4.7A)
GIN  A 600 (-3.1A)
 0.62A 3zosB-2hz0A:
30.1		 3zosB-2hz0A:
38.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2og8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 ALA A 271
LYS A 273
GLU A 288
THR A 316
HIS A 362
LEU A 371
ALA A 381
ASP A 382
PHE A 383
 1N8  A 501 ( 3.4A)
1N8  A 501 ( 3.4A)
1N8  A 501 ( 3.6A)
1N8  A 501 ( 3.3A)
None
1N8  A 501 ( 4.3A)
1N8  A 501 ( 3.3A)
1N8  A 501 ( 3.3A)
1N8  A 501 ( 4.3A)
 0.49A 3zosB-2og8A:
30.9		 3zosB-2og8A:
37.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2og8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 ALA A 271
THR A 316
HIS A 362
ARG A 363
LEU A 371
ALA A 381
ASP A 382
PHE A 383
 1N8  A 501 ( 3.4A)
1N8  A 501 ( 3.3A)
None
None
1N8  A 501 ( 4.3A)
1N8  A 501 ( 3.3A)
1N8  A 501 ( 3.3A)
1N8  A 501 ( 4.3A)
 0.66A 3zosB-2og8A:
30.9		 3zosB-2og8A:
37.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ogv MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
PRECURSOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 ALA A 614
LYS A 616
GLU A 633
THR A 663
HIS A 776
ARG A 777
LEU A 785
ASP A 796
 None
 1.07A 3zosB-2ogvA:
32.8		 3zosB-2ogvA:
35.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ogv MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
PRECURSOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 ALA A 614
LYS A 616
GLU A 633
THR A 663
LEU A 769
HIS A 776
LEU A 785
ASP A 796
 None
 0.88A 3zosB-2ogvA:
32.8		 3zosB-2ogvA:
35.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2p4i ANGIOPOIETIN-1
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 ALA A 853
ILE A 886
LEU A 955
HIS A 962
LEU A 971
ALA A 981
ASP A 982
PHE A 983
 MR9  A 301 (-3.5A)
MR9  A 301 (-4.0A)
MR9  A 301 (-4.4A)
MR9  A 301 (-4.5A)
MR9  A 301 (-4.5A)
MR9  A 301 (-3.2A)
MR9  A 301 (-4.2A)
MR9  A 301 (-4.4A)
 0.67A 3zosB-2p4iA:
12.2		 3zosB-2p4iA:
33.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2p4i ANGIOPOIETIN-1
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 853
LEU A 955
HIS A 962
ARG A 963
LEU A 971
ALA A 981
ASP A 982
 MR9  A 301 (-3.5A)
MR9  A 301 (-4.4A)
MR9  A 301 (-4.5A)
None
MR9  A 301 (-4.5A)
MR9  A 301 (-3.2A)
MR9  A 301 (-4.2A)
 0.78A 3zosB-2p4iA:
12.2		 3zosB-2p4iA:
33.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 515
GLU A 534
ILE A 548
LEU A 617
HIS A 624
LEU A 633
ALA A 643
 None
 0.72A 3zosB-2psqA:
23.7		 3zosB-2psqA:
33.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 515
LYS A 517
GLU A 534
ILE A 548
LEU A 617
HIS A 624
ALA A 643
 None
 0.83A 3zosB-2psqA:
23.7		 3zosB-2psqA:
33.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qlu ACTIVIN RECEPTOR
TYPE IIB

(Homo sapiens) 		PF00069
(Pkinase) 		8 ALA A 215
LYS A 217
GLU A 230
THR A 265
LEU A 301
HIS A 319
LEU A 328
ALA A 338
 ADE  A 488 (-3.2A)
None
None
ADE  A 488 (-4.3A)
None
None
ADE  A 488 (-4.4A)
None
 0.87A 3zosB-2qluA:
23.9		 3zosB-2qluA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qr7 RIBOSOMAL PROTEIN S6
KINASE ALPHA-3

(Mus musculus) 		PF00069
(Pkinase) 		7 ALA A 449
LYS A 451
GLU A 463
ILE A 477
THR A 493
LEU A 530
HIS A 537
 None
 0.71A 3zosB-2qr7A:
19.0		 3zosB-2qr7A:
24.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xik SERINE/THREONINE
PROTEIN KINASE 25

(Homo sapiens) 		PF00069
(Pkinase) 		7 ALA A  47
GLU A  66
LEU A 131
HIS A 138
ARG A 139
LEU A 147
ALA A 157
 J60  A1294 (-3.3A)
None
None
None
TPO  A 174 ( 2.9A)
J60  A1294 (-4.8A)
J60  A1294 ( 4.2A)
 0.76A 3zosB-2xikA:
17.9		 3zosB-2xikA:
24.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2xyu EPHRIN TYPE-A
RECEPTOR 4,

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		7 ALA A 651
ILE A 683
THR A 699
LEU A 737
HIS A 744
LEU A 753
ASP A 764
 Q9G  A1898 (-3.2A)
Q9G  A1898 ( 4.9A)
Q9G  A1898 (-3.5A)
None
None
Q9G  A1898 (-4.3A)
None
 0.77A 3zosB-2xyuA:
24.2		 3zosB-2xyuA:
35.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 ALA A 512
GLU A 531
ILE A 545
LEU A 614
HIS A 621
ARG A 622
LEU A 630
ALA A 640
PHE A 489
 C4F  A   1 (-3.3A)
None
C4F  A   1 ( 4.0A)
None
None
None
C4F  A   1 (-4.6A)
C4F  A   1 (-3.6A)
C4F  A   1 (-3.7A)
 0.87A 3zosB-3c4fA:
24.5		 3zosB-3c4fA:
37.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3d7u TYROSINE-PROTEIN
KINASE CSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 ALA A 220
LYS A 222
GLU A 236
THR A 266
LEU A 305
HIS A 312
ARG A 313
LEU A 321
 None
 0.64A 3zosB-3d7uA:
24.1		 3zosB-3d7uA:
32.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dko EPHRIN TYPE-A
RECEPTOR 7

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		7 ALA A 663
GLU A 682
LEU A 749
HIS A 756
LEU A 765
ASP A 776
PHE A 777
 IHZ  A1001 (-3.3A)
IHZ  A1001 (-3.8A)
None
IHZ  A1001 ( 4.9A)
IHZ  A1001 (-4.6A)
IHZ  A1001 (-4.8A)
IHZ  A1001 (-4.7A)
 0.77A 3zosB-3dkoA:
30.3		 3zosB-3dkoA:
34.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f2a PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1

(Homo sapiens) 		PF00069
(Pkinase) 		7 ALA A  65
LYS A  67
GLU A  89
ILE A 104
HIS A 165
ARG A 166
LEU A 174
 985  A   1 (-3.5A)
985  A   1 ( 2.8A)
MG  A 314 (-3.6A)
985  A   1 ( 4.7A)
None
None
985  A   1 (-4.8A)
 0.83A 3zosB-3f2aA:
15.6		 3zosB-3f2aA:
25.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gp0 MITOGEN-ACTIVATED
PROTEIN KINASE 11

(Homo sapiens) 		PF00069
(Pkinase) 		7 ALA A  51
LYS A  53
GLU A  71
ILE A  84
THR A 106
HIS A 148
ASP A 168
 NIL  A   1 (-3.7A)
None
NIL  A   1 (-3.7A)
NIL  A   1 (-4.4A)
NIL  A   1 (-3.3A)
NIL  A   1 (-4.3A)
NIL  A   1 (-4.6A)
 0.74A 3zosB-3gp0A:
22.0		 3zosB-3gp0A:
25.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 ALA A 859
LYS A 861
GLU A 878
LEU A1013
HIS A1020
ARG A1021
LEU A1029
ASP A1040
PHE A1041
 8ST  A2001 ( 3.8A)
8ST  A2001 (-4.0A)
8ST  A2001 (-3.7A)
8ST  A2001 (-4.6A)
8ST  A2001 ( 4.8A)
None
None
None
8ST  A2001 ( 3.7A)
 0.73A 3zosB-3hngA:
33.6		 3zosB-3hngA:
30.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kul EPHRIN TYPE-A
RECEPTOR 8

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		8 ALA A 665
LYS A 667
GLU A 684
ILE A 697
THR A 713
HIS A 758
ARG A 759
LEU A 767
 None
 1.03A 3zosB-3kulA:
24.5		 3zosB-3kulA:
37.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kul EPHRIN TYPE-A
RECEPTOR 8

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		8 ALA A 665
LYS A 667
GLU A 684
ILE A 697
THR A 713
LEU A 751
HIS A 758
LEU A 767
 None
 0.52A 3zosB-3kulA:
24.5		 3zosB-3kulA:
37.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lj0 SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A) 		8 ALA A 700
LYS A 702
GLU A 715
ILE A 729
LEU A 788
HIS A 795
ARG A 796
LEU A 804
 ADP  A2101 (-3.5A)
ADP  A2101 (-2.7A)
None
None
None
None
TPO  A 844 ( 3.0A)
ADP  A2101 (-4.4A)
 0.87A 3zosB-3lj0A:
20.8		 3zosB-3lj0A:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF08515
(TGF_beta_GS) 		9 ALA A 229
LYS A 231
GLU A 244
THR A 279
LEU A 315
HIS A 330
ARG A 331
LEU A 339
ALA A 349
 LDN  A   1 (-3.6A)
None
None
LDN  A   1 (-3.8A)
None
None
None
LDN  A   1 (-4.5A)
LDN  A   1 ( 3.8A)
 0.99A 3zosB-3mdyA:
24.0		 3zosB-3mdyA:
24.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mi9 CELL DIVISION
PROTEIN KINASE 9

(Homo sapiens) 		PF00069
(Pkinase) 		7 ALA A  46
LYS A  48
GLU A  66
HIS A 147
ARG A 148
LEU A 156
ALA A 166
 None
None
None
None
TPO  A 186 ( 2.8A)
None
None
 0.67A 3zosB-3mi9A:
22.0		 3zosB-3mi9A:
25.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 ALA A 227
LYS A 229
THR A 277
LEU A 313
HIS A 328
ARG A 329
LEU A 337
ALA A 347
 LDN  A 600 (-3.2A)
LDN  A 600 (-4.0A)
LDN  A 600 (-4.0A)
None
None
None
LDN  A 600 (-4.6A)
LDN  A 600 ( 3.8A)
 0.98A 3zosB-3my0A:
23.9		 3zosB-3my0A:
27.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 227
THR A 277
LEU A 313
HIS A 328
LEU A 337
ALA A 347
ASP A 348
 LDN  A 600 (-3.2A)
LDN  A 600 (-4.0A)
None
None
LDN  A 600 (-4.6A)
LDN  A 600 ( 3.8A)
None
 0.86A 3zosB-3my0A:
23.9		 3zosB-3my0A:
27.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1

(Arabidopsis
thaliana) 		PF07714
(Pkinase_Tyr) 		7 ALA A 576
LYS A 578
GLU A 596
THR A 625
LEU A 665
HIS A 674
LEU A 683
 STU  A   1 (-3.3A)
STU  A   1 (-3.5A)
None
STU  A   1 (-4.1A)
None
None
STU  A   1 (-4.3A)
 0.61A 3zosB-3ppzA:
27.4		 3zosB-3ppzA:
31.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q4t ACTIVIN RECEPTOR
TYPE-2A

(Homo sapiens) 		PF00069
(Pkinase) 		8 ALA A 217
LYS A 219
GLU A 232
LEU A 303
HIS A 320
ARG A 321
LEU A 329
ALA A 339
 TAK  A   2 (-3.5A)
TAK  A   2 (-2.9A)
TAK  A   2 ( 4.9A)
None
None
None
TAK  A   2 (-4.6A)
TAK  A   2 ( 4.2A)
 1.20A 3zosB-3q4tA:
23.1		 3zosB-3q4tA:
26.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q4t ACTIVIN RECEPTOR
TYPE-2A

(Homo sapiens) 		PF00069
(Pkinase) 		8 ALA A 217
LYS A 219
THR A 267
LEU A 303
HIS A 320
ARG A 321
LEU A 329
ALA A 339
 TAK  A   2 (-3.5A)
TAK  A   2 (-2.9A)
TAK  A   2 (-3.5A)
None
None
None
TAK  A   2 (-4.6A)
TAK  A   2 ( 4.2A)
 1.02A 3zosB-3q4tA:
23.1		 3zosB-3q4tA:
26.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q5i PROTEIN KINASE

(Plasmodium
berghei) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		9 ALA A  84
LYS A  86
GLU A 115
ILE A 128
THR A 144
LEU A 181
HIS A 188
ARG A 189
LEU A 197
 ANP  A1634 (-3.6A)
ANP  A1634 (-3.1A)
None
None
ANP  A1634 (-4.6A)
None
None
None
ANP  A1634 (-4.4A)
 0.79A 3zosB-3q5iA:
20.7		 3zosB-3q5iA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s95 LIM DOMAIN KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LYS A 368
GLU A 384
THR A 413
LEU A 451
HIS A 458
ARG A 459
LEU A 467
ALA A 477
 STU  A   1 (-3.1A)
STU  A   1 (-3.7A)
STU  A   1 (-3.9A)
None
None
None
STU  A   1 (-4.6A)
STU  A   1 ( 4.1A)
 1.01A 3zosB-3s95A:
24.2		 3zosB-3s95A:
29.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3tt0 BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 ALA A 512
LYS A 514
GLU A 531
ILE A 545
LEU A 614
HIS A 621
LEU A 630
ALA A 640
 07J  A   1 (-3.5A)
07J  A   1 (-4.5A)
07J  A   1 (-3.8A)
07J  A   1 (-3.8A)
None
None
07J  A   1 ( 4.4A)
07J  A   1 (-3.2A)
 0.68A 3zosB-3tt0A:
30.4		 3zosB-3tt0A:
31.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 866
GLU A 885
LEU A1019
HIS A1026
ARG A1027
LEU A1035
ASP A1046
 4TT  A2001 (-3.5A)
None
None
None
None
4TT  A2001 (-4.8A)
None
 0.72A 3zosB-3vidA:
30.3		 3zosB-3vidA:
31.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zfx EPHRIN TYPE-B
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 ALA A 649
LYS A 651
GLU A 668
ILE A 681
THR A 697
LEU A 735
HIS A 742
ARG A 743
 None
 0.92A 3zosB-3zfxA:
30.5		 3zosB-3zfxA:
37.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zfx EPHRIN TYPE-B
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 ALA A 649
LYS A 651
ILE A 681
THR A 697
LEU A 735
HIS A 742
ARG A 743
LEU A 751
 None
 0.84A 3zosB-3zfxA:
30.5		 3zosB-3zfxA:
37.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 ALA A 866
LYS A 868
GLU A 885
HIS A1026
ARG A1027
LEU A1035
ASP A1046
PHE A1047
 B49  A2000 (-3.5A)
B49  A2000 (-3.0A)
None
None
None
B49  A2000 (-4.5A)
None
B49  A2000 (-4.0A)
 1.11A 3zosB-4agdA:
33.5		 3zosB-4agdA:
30.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 ALA A 866
LYS A 868
GLU A 885
LEU A1019
HIS A1026
LEU A1035
ASP A1046
PHE A1047
 B49  A2000 (-3.5A)
B49  A2000 (-3.0A)
None
None
None
B49  A2000 (-4.5A)
None
B49  A2000 (-4.0A)
 0.89A 3zosB-4agdA:
33.5		 3zosB-4agdA:
30.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aw2 SERINE/THREONINE-PRO
TEIN KINASE MRCK
ALPHA

(Rattus
norvegicus) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		7 ALA A 104
LYS A 106
GLU A 125
HIS A 199
ARG A 200
LEU A 208
ALA A 218
 EDO  A1420 (-3.4A)
EDO  A1419 (-3.3A)
EDO  A1419 (-3.0A)
None
None
EDO  A1420 ( 4.8A)
None
 0.85A 3zosB-4aw2A:
20.0		 3zosB-4aw2A:
25.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c02 ACTIVIN RECEPTOR
TYPE-1

(Homo sapiens) 		PF00069
(Pkinase)
PF08515
(TGF_beta_GS) 		7 ALA A 233
LYS A 235
THR A 283
LEU A 319
HIS A 334
LEU A 343
ALA A 353
 TAK  A1507 (-3.3A)
TAK  A1507 ( 4.5A)
TAK  A1507 (-3.6A)
None
None
TAK  A1507 (-4.7A)
TAK  A1507 ( 4.2A)
 0.78A 3zosB-4c02A:
23.9		 3zosB-4c02A:
28.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ckr EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		10 ALA A 653
GLU A 672
ILE A 685
THR A 701
LEU A 757
HIS A 764
LEU A 773
ALA A 783
ASP A 784
PHE A 785
 DI1  A1000 (-3.6A)
DI1  A1000 (-3.8A)
DI1  A1000 (-4.5A)
DI1  A1000 (-3.6A)
DI1  A1000 (-4.4A)
DI1  A1000 (-3.8A)
DI1  A1000 (-4.5A)
DI1  A1000 (-3.7A)
DI1  A1000 (-4.1A)
DI1  A1000 (-4.5A)
 0.51A 3zosB-4ckrA:
43.7		 3zosB-4ckrA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ckr EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 653
HIS A 764
ARG A 765
LEU A 773
ALA A 783
ASP A 784
PHE A 785
 DI1  A1000 (-3.6A)
DI1  A1000 (-3.8A)
None
DI1  A1000 (-4.5A)
DI1  A1000 (-3.7A)
DI1  A1000 (-4.1A)
DI1  A1000 (-4.5A)
 0.82A 3zosB-4ckrA:
43.7		 3zosB-4ckrA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ckr EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		10 ALA A 653
LYS A 655
GLU A 672
ILE A 685
THR A 701
LEU A 757
HIS A 764
LEU A 773
ALA A 783
ASP A 784
 DI1  A1000 (-3.6A)
DI1  A1000 (-3.9A)
DI1  A1000 (-3.8A)
DI1  A1000 (-4.5A)
DI1  A1000 (-3.6A)
DI1  A1000 (-4.4A)
DI1  A1000 (-3.8A)
DI1  A1000 (-4.5A)
DI1  A1000 (-3.7A)
DI1  A1000 (-4.1A)
 0.46A 3zosB-4ckrA:
43.7		 3zosB-4ckrA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ckr EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 653
LYS A 655
HIS A 764
ARG A 765
LEU A 773
ALA A 783
ASP A 784
 DI1  A1000 (-3.6A)
DI1  A1000 (-3.9A)
DI1  A1000 (-3.8A)
None
DI1  A1000 (-4.5A)
DI1  A1000 (-3.7A)
DI1  A1000 (-4.1A)
 0.85A 3zosB-4ckrA:
43.7		 3zosB-4ckrA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4crs SERINE/THREONINE-PRO
TEIN KINASE N2

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		7 ALA A 684
LYS A 686
GLU A 705
LEU A 773
ARG A 781
LEU A 789
ALA A 799
 AGS  A1985 (-3.5A)
AGS  A1985 (-3.0A)
None
None
TPO  A 816 ( 3.0A)
AGS  A1985 (-4.8A)
AGS  A1985 ( 4.5A)
 0.79A 3zosB-4crsA:
20.7		 3zosB-4crsA:
24.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ez5 CYCLIN-DEPENDENT
KINASE 6

(Homo sapiens) 		PF00069
(Pkinase) 		7 ALA A  41
LYS A  43
LEU A 136
HIS A 143
ARG A 144
LEU A 152
ALA A 162
 0RS  A 900 ( 3.7A)
0RS  A 900 (-3.3A)
None
None
None
0RS  A 900 (-4.3A)
0RS  A 900 (-3.6A)
 0.75A 3zosB-4ez5A:
21.5		 3zosB-4ez5A:
28.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hvi TYROSINE-PROTEIN
KINASE JAK3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 ALA A 853
LYS A 855
GLU A 871
HIS A 947
ARG A 948
LEU A 956
ALA A 966
ASP A 967
 19S  A1201 (-3.3A)
19S  A1201 (-3.5A)
None
None
None
19S  A1201 (-4.5A)
19S  A1201 ( 4.1A)
19S  A1201 ( 4.1A)
 1.29A 3zosB-4hviA:
29.2		 3zosB-4hviA:
33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hvi TYROSINE-PROTEIN
KINASE JAK3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 853
LYS A 855
GLU A 871
LEU A 940
HIS A 947
LEU A 956
ALA A 966
 19S  A1201 (-3.3A)
19S  A1201 (-3.5A)
None
None
None
19S  A1201 (-4.5A)
19S  A1201 ( 4.1A)
 0.54A 3zosB-4hviA:
29.2		 3zosB-4hviA:
33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4k33 FIBROBLAST GROWTH
FACTOR RECEPTOR 3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 ALA A 506
LYS A 508
GLU A 525
ILE A 539
LEU A 608
HIS A 615
ARG A 616
LEU A 624
ALA A 634
 ACP  A 801 (-3.3A)
ACP  A 801 (-2.7A)
ACP  A 801 ( 4.8A)
None
None
None
None
ACP  A 801 (-4.4A)
None
 1.01A 3zosB-4k33A:
6.3		 3zosB-4k33A:
34.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m69 RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 3

(Mus musculus) 		PF00069
(Pkinase) 		7 ALA A  49
LYS A  51
THR A  95
LEU A 132
HIS A 141
LEU A 150
ALA A 160
 ANP  A 401 (-3.1A)
ANP  A 401 (-2.9A)
ANP  A 401 (-3.8A)
None
None
ANP  A 401 (-4.8A)
None
 0.80A 3zosB-4m69A:
22.1		 3zosB-4m69A:
27.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o27 SERINE/THREONINE-PRO
TEIN KINASE 24

(Homo sapiens) 		PF00069
(Pkinase) 		8 ALA B  51
LYS B  53
GLU B  70
LEU B 135
HIS B 142
ARG B 143
LEU B 151
ALA B 161
 ADP  B 500 (-3.3A)
ADP  B 500 (-3.1A)
None
None
None
None
ADP  B 500 (-4.7A)
None
 0.78A 3zosB-4o27B:
23.9		 3zosB-4o27B:
26.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o38 CYCLIN-G-ASSOCIATED
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		7 ALA A  67
LYS A  69
GLU A  85
THR A 123
HIS A 171
ARG A 172
LEU A 180
 SIN  A 401 ( 3.7A)
None
None
None
None
None
SIN  A 401 ( 4.5A)
 0.77A 3zosB-4o38A:
20.0		 3zosB-4o38A:
25.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 ALA A 642
LYS A 644
GLU A 661
LEU A 802
HIS A 809
ARG A 810
LEU A 818
ASP A 829
PHE A 830
 P30  A1001 (-3.4A)
P30  A1001 (-3.4A)
P30  A1001 (-3.6A)
None
P30  A1001 ( 4.3A)
None
P30  A1001 (-4.6A)
None
P30  A1001 (-3.9A)
 0.76A 3zosB-4rt7A:
27.5		 3zosB-4rt7A:
28.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tpt LIM DOMAIN KINASE 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 THR A 405
LEU A 442
HIS A 449
ARG A 450
LEU A 458
ALA A 468
ASP A 469
PHE A 470
 35H  A 701 (-3.8A)
35H  A 701 ( 4.7A)
35H  A 701 ( 4.4A)
None
None
35H  A 701 (-3.5A)
35H  A 701 (-4.7A)
35H  A 701 (-4.4A)
 1.11A 3zosB-4tptA:
20.4		 3zosB-4tptA:
29.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL

(synthetic
construct) 		PF07714
(Pkinase_Tyr) 		8 ALA A  35
LYS A  37
GLU A  52
THR A  81
HIS A 127
LEU A 136
ALA A 146
ASP A 147
 ACP  A1264 (-2.9A)
None
None
ACP  A1264 (-4.5A)
None
ACP  A1264 ( 4.8A)
None
None
 0.94A 3zosB-4ueuA:
30.1		 3zosB-4ueuA:
39.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uy9 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 9

(Homo sapiens) 		PF00069
(Pkinase) 		7 ALA A 169
LYS A 171
ILE A 204
LEU A 256
HIS A 266
ARG A 267
LEU A 275
 None
 0.78A 3zosB-4uy9A:
25.9		 3zosB-4uy9A:
29.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xbr PROTEIN
FAM212A,SERINE/THREO
NINE-PROTEIN KINASE
PAK 4

(Homo sapiens) 		PF00069
(Pkinase)
PF15342
(FAM212) 		7 ALA A 348
LYS A 350
GLU A 366
LEU A 431
HIS A 438
ARG A 439
LEU A 447
 ATP  A 601 ( 3.7A)
ATP  A 601 (-2.8A)
ATP  A 601 ( 3.7A)
None
None
SEP  A 474 ( 3.2A)
None
 0.82A 3zosB-4xbrA:
15.3		 3zosB-4xbrA:
23.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xcu FIBROBLAST GROWTH
FACTOR RECEPTOR 4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 501
GLU A 520
ILE A 534
LEU A 603
HIS A 610
LEU A 619
ALA A 629
 40M  A1002 ( 4.1A)
40M  A1002 (-3.7A)
40M  A1002 (-4.0A)
None
None
40M  A1002 (-4.5A)
40M  A1002 (-3.0A)
 0.56A 3zosB-4xcuA:
29.5		 3zosB-4xcuA:
38.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xcu FIBROBLAST GROWTH
FACTOR RECEPTOR 4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 501
LYS A 503
GLU A 520
ILE A 534
HIS A 610
LEU A 619
ALA A 629
 40M  A1002 ( 4.1A)
40M  A1002 (-4.0A)
40M  A1002 (-3.7A)
40M  A1002 (-4.0A)
None
40M  A1002 (-4.5A)
40M  A1002 (-3.0A)
 0.71A 3zosB-4xcuA:
29.5		 3zosB-4xcuA:
38.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 642
GLU A 661
LEU A 802
HIS A 809
LEU A 818
ASP A 829
PHE A 830
 P30  A1001 (-3.5A)
P30  A1001 (-3.1A)
None
P30  A1001 (-4.4A)
P30  A1001 (-4.3A)
None
P30  A1001 ( 4.1A)
 0.61A 3zosB-4xufA:
26.4		 3zosB-4xufA:
33.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 ALA A 642
LYS A 644
GLU A 661
HIS A 809
ARG A 810
LEU A 818
ASP A 829
PHE A 830
 P30  A1001 (-3.5A)
P30  A1001 ( 4.0A)
P30  A1001 (-3.1A)
P30  A1001 (-4.4A)
None
P30  A1001 (-4.3A)
None
P30  A1001 ( 4.1A)
 1.10A 3zosB-4xufA:
26.4		 3zosB-4xufA:
33.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE

(Bos taurus) 		PF00169
(PH)
PF00779
(BTK)
PF07714
(Pkinase_Tyr) 		7 ALA A 428
LYS A 430
THR A 474
LEU A 512
HIS A 519
ARG A 520
LEU A 528
 746  A 702 (-2.4A)
746  A 702 (-3.7A)
746  A 702 (-3.7A)
None
None
None
746  A 702 (-4.4A)
 0.77A 3zosB-4y93A:
29.4		 3zosB-4y93A:
24.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yff SERINE/THREONINE-PRO
TEIN KINASE TNNI3K

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 ALA A 488
LYS A 490
GLU A 509
ILE A 522
LEU A 577
HIS A 586
LEU A 595
ALA A 605
 4CV  A 801 (-3.5A)
4CV  A 801 (-3.9A)
None
4CV  A 801 ( 4.2A)
None
None
4CV  A 801 (-4.4A)
4CV  A 801 ( 3.9A)
 0.77A 3zosB-4yffA:
24.3		 3zosB-4yffA:
29.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yff SERINE/THREONINE-PRO
TEIN KINASE TNNI3K

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 ALA A 488
LYS A 490
GLU A 509
ILE A 522
THR A 539
LEU A 577
LEU A 595
ALA A 605
 4CV  A 801 (-3.5A)
4CV  A 801 (-3.9A)
None
4CV  A 801 ( 4.2A)
4CV  A 801 (-2.8A)
None
4CV  A 801 (-4.4A)
4CV  A 801 ( 3.9A)
 0.67A 3zosB-4yffA:
24.3		 3zosB-4yffA:
29.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE

(Eimeria tenella) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		7 ALA A  55
LYS A  57
GLU A  76
THR A 105
HIS A 149
ARG A 150
LEU A 158
 ADP  A 506 (-3.3A)
ADP  A 506 (-2.4A)
None
ADP  A 506 ( 4.6A)
None
None
ADP  A 506 (-4.7A)
 0.82A 3zosB-4ysjA:
22.5		 3zosB-4ysjA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z7g SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1

(Homo sapiens) 		PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A) 		7 ALA A 597
LYS A 599
GLU A 612
ILE A 626
LEU A 679
HIS A 686
LEU A 695
 None
 0.84A 3zosB-4z7gA:
19.0		 3zosB-4z7gA:
22.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 ALA A 512
LYS A 514
GLU A 531
ILE A 545
LEU A 614
HIS A 621
ARG A 622
LEU A 630
ALA A 640
 38O  A1769 (-3.6A)
38O  A1769 ( 3.1A)
EDO  A1766 (-4.1A)
38O  A1769 ( 3.3A)
None
None
None
38O  A1769 (-4.6A)
EDO  A1766 ( 4.4A)
 0.64A 3zosB-5a46A:
30.7		 3zosB-5a46A:
31.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e8y TGF-BETA RECEPTOR
TYPE-2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 ALA A 275
LYS A 277
GLU A 290
THR A 325
LEU A 361
HIS A 377
ARG A 378
LEU A 386
 STU  A 601 (-3.1A)
STU  A 601 (-2.4A)
STU  A 601 ( 3.8A)
STU  A 601 ( 3.7A)
None
None
None
STU  A 601 (-3.9A)
 0.79A 3zosB-5e8yA:
23.8		 3zosB-5e8yA:
26.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 ALA A 928
LYS A 930
GLU A 947
ILE A 960
LEU A1014
HIS A1021
ARG A1022
LEU A1030
 5U3  A1200 (-3.5A)
None
None
5U3  A1200 (-4.6A)
None
None
None
5U3  A1200 (-4.4A)
 1.19A 3zosB-5f1zA:
27.1		 3zosB-5f1zA:
34.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 ALA A 625
LYS A 627
GLU A 644
THR A 674
LEU A 809
HIS A 816
LEU A 825
ASP A 836
PHE A 837
 748  A1001 (-3.7A)
748  A1001 (-4.0A)
748  A1001 (-3.3A)
748  A1001 (-3.2A)
748  A1001 ( 4.6A)
748  A1001 (-3.8A)
748  A1001 (-4.3A)
748  A1001 (-4.8A)
748  A1001 (-3.7A)
 0.58A 3zosB-5grnA:
28.1		 3zosB-5grnA:
30.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5idn CYCLIN-DEPENDENT
KINASE 8

(Homo sapiens) 		PF00069
(Pkinase) 		7 ALA A  50
LYS A  52
GLU A  66
ILE A  79
LEU A 142
HIS A 149
ARG A 150
 6A7  A 401 (-3.3A)
6A7  A 401 ( 2.9A)
FMT  A 404 ( 4.2A)
6A7  A 401 (-4.2A)
None
FMT  A 403 (-4.6A)
None
 0.83A 3zosB-5idnA:
20.5		 3zosB-5idnA:
26.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5idn CYCLIN-DEPENDENT
KINASE 8

(Homo sapiens) 		PF00069
(Pkinase) 		7 ALA A  50
LYS A  52
ILE A  79
HIS A 149
LEU A 158
ALA A 172
ASP A 173
 6A7  A 401 (-3.3A)
6A7  A 401 ( 2.9A)
6A7  A 401 (-4.2A)
FMT  A 403 (-4.6A)
6A7  A 401 (-4.8A)
6A7  A 401 ( 4.1A)
FMT  A 403 ( 3.3A)
 0.74A 3zosB-5idnA:
20.5		 3zosB-5idnA:
26.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5idn CYCLIN-DEPENDENT
KINASE 8

(Homo sapiens) 		PF00069
(Pkinase) 		8 ALA A  50
LYS A  52
ILE A  79
LEU A 142
HIS A 149
ARG A 150
LEU A 158
ALA A 172
 6A7  A 401 (-3.3A)
6A7  A 401 ( 2.9A)
6A7  A 401 (-4.2A)
None
FMT  A 403 (-4.6A)
None
6A7  A 401 (-4.8A)
6A7  A 401 ( 4.1A)
 0.64A 3zosB-5idnA:
20.5		 3zosB-5idnA:
26.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3

(Homo sapiens) 		PF00069
(Pkinase) 		7 ALA A  43
LYS A  45
GLU A  61
LEU A 127
HIS A 134
LEU A 143
ALA A 153
 6G2  A 901 (-3.2A)
6G2  A 901 ( 3.9A)
None
None
None
6G2  A 901 (-4.7A)
6G2  A 901 ( 4.2A)
 0.67A 3zosB-5j5tA:
20.9		 3zosB-5j5tA:
23.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5l6o EPHRIN TYPE-B
RECEPTOR 3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 663
ILE A 695
THR A 711
LEU A 749
HIS A 756
LEU A 765
ASP A 776
 6P6  A1001 (-3.3A)
None
6P6  A1001 (-3.5A)
None
DIO  A1002 (-4.1A)
6P6  A1001 (-4.5A)
None
 0.42A 3zosB-5l6oA:
31.9		 3zosB-5l6oA:
37.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5l6o EPHRIN TYPE-B
RECEPTOR 3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ILE A 695
THR A 711
LEU A 749
HIS A 756
ARG A 757
LEU A 765
ASP A 776
 None
6P6  A1001 (-3.5A)
None
DIO  A1002 (-4.1A)
None
6P6  A1001 (-4.5A)
None
 0.73A 3zosB-5l6oA:
31.9		 3zosB-5l6oA:
37.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5myv SRSF PROTEIN KINASE
2,SRSF PROTEIN
KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		7 ALA A 119
LYS A 121
GLU A 136
LEU A 215
HIS A 223
LEU A 232
ALA A 540
 W4A  A 716 ( 3.9A)
SO4  A 702 (-3.3A)
DMS  A 717 (-4.0A)
None
None
None
DMS  A 717 ( 4.5A)
 0.83A 3zosB-5myvA:
12.7		 3zosB-5myvA:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vil MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 5

(Homo sapiens) 		no annotation 7 ALA A 707
LYS A 709
GLU A 725
LEU A 794
HIS A 801
ARG A 802
LEU A 810
 9E1  A1001 (-3.5A)
9E1  A1001 (-2.8A)
None
None
None
None
9E1  A1001 (-4.5A)
 0.77A 3zosB-5vilA:
18.2		 3zosB-5vilA:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xv7 SERINE-ARGININE (SR)
PROTEIN KINASE 1

(Homo sapiens) 		no annotation 7 ALA A 107
LYS A 109
GLU A 124
LEU A 203
HIS A 211
LEU A 220
ALA A 496
 EMH  A 705 (-3.6A)
EMH  A 705 ( 4.8A)
None
None
None
None
EMH  A 705 ( 4.0A)
 0.80A 3zosB-5xv7A:
20.3		 3zosB-5xv7A:
11.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y86 DUAL SPECIFICITY
TYROSINE-PHOSPHORYLA
TION-REGULATED
KINASE 3

(Homo sapiens) 		no annotation 7 ALA A 236
LYS A 238
GLU A 253
ILE A 272
LEU A 326
HIS A 333
LEU A 342
 HRM  A 601 (-3.5A)
HRM  A 601 (-3.3A)
HRM  A 601 ( 4.6A)
HRM  A 601 ( 4.8A)
None
None
None
 0.74A 3zosB-5y86A:
14.4		 3zosB-5y86A:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b3e CYCLIN-DEPENDENT
KINASE 12

(Homo sapiens) 		no annotation 7 ALA A 754
LYS A 756
GLU A 774
HIS A 857
ARG A 858
LEU A 866
ALA A 876
 CJM  A1102 (-3.1A)
None
None
None
TPO  A 893 ( 3.0A)
CJM  A1102 (-4.4A)
CJM  A1102 (-3.6A)
 0.74A 3zosB-6b3eA:
22.3		 3zosB-6b3eA:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cnh SERINE/THREONINE-PRO
TEIN KINASE PRP4
HOMOLOG

(Homo sapiens) 		no annotation 7 ALA A 715
GLU A 732
LEU A 806
HIS A 813
LEU A 822
ASP A 834
PHE A 835
 919  A1101 (-3.5A)
919  A1101 (-3.7A)
None
919  A1101 (-4.2A)
None
919  A1101 (-4.5A)
919  A1101 ( 4.1A)
 0.69A 3zosB-6cnhA:
2.3		 3zosB-6cnhA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cz4 PROTEIN-TYROSINE
KINASE 6

(Homo sapiens) 		no annotation 7 ALA A 217
THR A 264
LEU A 303
HIS A 310
ARG A 311
LEU A 319
ASP A 330
 FKY  A9001 (-3.3A)
FKY  A9001 (-3.0A)
FKY  A9001 (-4.4A)
FKY  A9001 (-3.9A)
None
FKY  A9001 ( 4.9A)
None
 0.83A 3zosB-6cz4A:
27.7		 3zosB-6cz4A:
14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gng GLYCOGEN SYNTHASE
KINASE-3 BETA

(Homo sapiens) 		PF00069
(Pkinase) 		5 ILE A 100
MET A 101
LEU A 104
ILE A 109
TYR A 134
 None
 0.59A 3zosB-1gngA:
20.3		 3zosB-1gngA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1go3 DNA-DIRECTED RNA
POLYMERASE SUBUNIT E
DNA-DIRECTED RNA
POLYMERASE SUBUNIT F

(Methanocaldococcus
jannaschii) 		PF00575
(S1)
PF03874
(RNA_pol_Rpb4)
PF03876
(SHS2_Rpb7-N) 		5 LEU F  41
LEU F  59
ILE F  72
TYR E   2
MET E   1
 None
 1.20A 3zosB-1go3F:
undetectable		 3zosB-1go3F:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h09 LYSOZYME

(Streptococcus
virus Cp1) 		PF01183
(Glyco_hydro_25)
PF01473
(CW_binding_1) 		5 LEU A  89
ILE A 185
LEU A 187
ILE A 171
ILE A 150
 None
 1.25A 3zosB-1h09A:
undetectable		 3zosB-1h09A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1itx GLYCOSYL HYDROLASE

(Bacillus
circulans) 		PF00704
(Glyco_hydro_18) 		5 LEU A 118
ILE A 250
LEU A 248
ILE A 231
TYR A 194
 None
 1.22A 3zosB-1itxA:
undetectable		 3zosB-1itxA:
20.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1luf MUSCLE-SPECIFIC
TYROSINE KINASE
RECEPTOR MUSK

(Rattus
norvegicus) 		PF07714
(Pkinase_Tyr) 		5 MET A 629
ILE A 637
TYR A 656
MET A 657
ILE A 740
 None
 0.71A 3zosB-1lufA:
35.7		 3zosB-1lufA:
39.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tua HYPOTHETICAL PROTEIN
APE0754

(Aeropyrum
pernix) 		PF00013
(KH_1) 		5 LEU A 156
ILE A 111
MET A 125
TYR A 129
ILE A 112
 None
 1.26A 3zosB-1tuaA:
undetectable		 3zosB-1tuaA:
20.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1u59 TYROSINE-PROTEIN
KINASE ZAP-70

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 344
ILE A 389
LEU A 393
ILE A 398
ILE A 477
 STU  A 100 (-3.8A)
None
None
None
None
 0.81A 3zosB-1u59A:
29.0		 3zosB-1u59A:
33.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1u59 TYROSINE-PROTEIN
KINASE ZAP-70

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 344
ILE A 389
MET A 390
ILE A 398
ILE A 477
 STU  A 100 (-3.8A)
None
None
None
None
 0.75A 3zosB-1u59A:
29.0		 3zosB-1u59A:
33.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A  15
ILE A  58
LEU A  62
TYR A  86
ILE A 146
 HYM  A 400 (-4.2A)
None
None
HYM  A 400 (-4.7A)
None
 0.73A 3zosB-1zltA:
20.3		 3zosB-1zltA:
24.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU X  17
ILE X  57
MET X  58
TYR X  84
MET X  85
ILE X 146
 STU  X 902 (-3.8A)
None
None
STU  X 902 (-4.6A)
None
None
 0.69A 3zosB-2dq7X:
29.9		 3zosB-2dq7X:
35.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hak SERINE/THREONINE-PRO
TEIN KINASE MARK1

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		5 ILE A 103
LEU A 107
ILE A 112
TYR A 131
ILE A 191
 None
 0.68A 3zosB-2hakA:
20.2		 3zosB-2hakA:
26.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i2x METHYLTRANSFERASE 1

(Methanosarcina
barkeri) 		PF12176
(MtaB) 		5 LEU A 161
ILE A 108
MET A 109
ILE A  81
ILE A  43
 None
 1.29A 3zosB-2i2xA:
undetectable		 3zosB-2i2xA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i6l MITOGEN-ACTIVATED
PROTEIN KINASE 6

(Homo sapiens) 		PF00069
(Pkinase) 		6 ILE A  68
LEU A  72
ILE A  77
TYR A 110
MET A 111
ILE A 169
 None
 0.83A 3zosB-2i6lA:
21.9		 3zosB-2i6lA:
27.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i79 ACETYLTRANSFERASE,
GNAT FAMILY

(Streptococcus
pneumoniae) 		PF00583
(Acetyltransf_1) 		5 LEU A  41
ILE A  92
LEU A  90
ILE A  76
ILE A  60
 None
ACO  A 402 (-4.7A)
None
None
None
 1.00A 3zosB-2i79A:
undetectable		 3zosB-2i79A:
21.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2og8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 251
MET A 292
TYR A 318
MET A 319
ILE A 380
 None
1N8  A 501 ( 3.6A)
1N8  A 501 ( 3.7A)
1N8  A 501 ( 4.4A)
None
 0.72A 3zosB-2og8A:
30.9		 3zosB-2og8A:
37.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ogv MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
PRECURSOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 588
ILE A 636
MET A 637
ILE A 646
TYR A 665
ILE A 794
 None
 0.97A 3zosB-2ogvA:
32.8		 3zosB-2ogvA:
35.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 487
MET A 538
ILE A 547
TYR A 566
ILE A 642
 None
 0.70A 3zosB-2psqA:
23.7		 3zosB-2psqA:
33.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2r2p EPHRIN TYPE-A
RECEPTOR 5

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		5 ILE A 727
MET A 728
ILE A 736
TYR A 755
MET A 756
 None
 0.68A 3zosB-2r2pA:
30.7		 3zosB-2r2pA:
35.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v6z DNA POLYMERASE
EPSILON SUBUNIT 2

(Homo sapiens) 		PF12213
(Dpoe2NT) 		5 LEU M  63
ILE M  50
LEU M  53
ILE M  72
ILE M  73
 None
 1.25A 3zosB-2v6zM:
undetectable		 3zosB-2v6zM:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y4o PHENYLACETATE-COENZY
ME A LIGASE

(Burkholderia
cenocepacia) 		PF00501
(AMP-binding)
PF14535
(AMP-binding_C_2) 		5 LEU A 193
ILE A 151
LEU A 136
ILE A 184
ILE A 213
 None
 1.24A 3zosB-2y4oA:
undetectable		 3zosB-2y4oA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2za1 OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE

(Plasmodium
falciparum) 		PF00215
(OMPdecase) 		5 LEU A   7
ILE A 316
LEU A 273
ILE A 266
ILE A 292
 None
 1.18A 3zosB-2za1A:
undetectable		 3zosB-2za1A:
21.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 487
MET A 538
ILE A 547
TYR A 566
ILE A 642
 M33  A1996 (-4.0A)
None
None
M33  A1996 ( 4.7A)
None
 0.60A 3zosB-3b2tA:
23.4		 3zosB-3b2tA:
34.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 484
MET A 535
ILE A 544
TYR A 563
ILE A 639
 C4F  A   1 ( 3.9A)
C4F  A   1 ( 3.7A)
None
None
None
 0.62A 3zosB-3c4fA:
24.5		 3zosB-3c4fA:
37.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d9y PROFILIN

(Schizosaccharomyces
pombe) 		PF00235
(Profilin) 		5 LEU A 121
ILE A  61
LEU A  63
TYR A   5
ILE A  43
 None
 1.15A 3zosB-3d9yA:
undetectable		 3zosB-3d9yA:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e3b CASEIN KINASE II
SUBUNIT ALPHA'

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU X  46
ILE X  85
LEU X  89
ILE X  95
TYR X 116
 CCK  X 351 (-4.0A)
None
None
None
CCK  X 351 (-4.3A)
 0.84A 3zosB-3e3bX:
11.9		 3zosB-3e3bX:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e3p PROTEIN KINASE,
PUTATIVE GLYCOGEN
SYNTHASE KINASE

(Leishmania
major) 		PF00069
(Pkinase) 		5 LEU A  36
ILE A  64
MET A  65
LEU A  68
ILE A  76
 None
 1.17A 3zosB-3e3pA:
18.4		 3zosB-3e3pA:
24.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eb0 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		6 LEU A  15
ILE A  53
MET A  54
LEU A  57
ILE A  62
TYR A 119
 DRK  A 384 (-3.8A)
None
None
None
None
DRK  A 384 (-4.4A)
 0.50A 3zosB-3eb0A:
21.0		 3zosB-3eb0A:
24.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fe3 MAP/MICROTUBULE
AFFINITY-REGULATING
KINASE 3

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		5 ILE A 106
LEU A 110
ILE A 115
TYR A 134
ILE A 194
 None
 0.89A 3zosB-3fe3A:
15.5		 3zosB-3fe3A:
25.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3fzp PROTEIN TYROSINE
KINASE 2 BETA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 431
ILE A 477
MET A 478
LEU A 481
ILE A 486
 AGS  A 999 ( 4.4A)
None
None
None
None
 1.14A 3zosB-3fzpA:
30.3		 3zosB-3fzpA:
33.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gf7 GLUTACONYL-COA
DECARBOXYLASE
SUBUNIT A

([Clostridium]
symbiosum) 		PF01039
(Carboxyl_trans) 		5 LEU A 371
ILE A 330
LEU A 414
ILE A 454
ILE A 316
 None
 1.13A 3zosB-3gf7A:
undetectable		 3zosB-3gf7A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hdg UNCHARACTERIZED
PROTEIN

(Wolinella
succinogenes) 		PF00072
(Response_reg) 		5 LEU A 101
ILE A 111
LEU A  24
ILE A  13
ILE A  11
 None
 1.23A 3zosB-3hdgA:
undetectable		 3zosB-3hdgA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		5 ILE A 103
LEU A 107
ILE A 112
TYR A 131
ILE A 191
 None
 0.82A 3zosB-3iecA:
22.0		 3zosB-3iecA:
26.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		5 ILE A 103
MET A 104
ILE A 112
TYR A 131
ILE A 191
 None
 0.99A 3zosB-3iecA:
22.0		 3zosB-3iecA:
26.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kul EPHRIN TYPE-A
RECEPTOR 8

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		5 ILE A 687
MET A 688
ILE A 696
TYR A 715
MET A 716
 None
None
None
GOL  A 403 (-4.1A)
None
 0.89A 3zosB-3kulA:
24.5		 3zosB-3kulA:
37.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l77 SHORT-CHAIN ALCOHOL
DEHYDROGENASE

(Thermococcus
sibiricus) 		PF00106
(adh_short) 		5 LEU A  89
ILE A  41
LEU A  30
ILE A   6
ILE A  17
 None
 1.20A 3zosB-3l77A:
undetectable		 3zosB-3l77A:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m1r FORMIMIDOYLGLUTAMASE

(Bacillus
subtilis) 		PF00491
(Arginase) 		5 LEU A 307
ILE A  34
LEU A  87
ILE A  40
ILE A 122
 None
 1.01A 3zosB-3m1rA:
undetectable		 3zosB-3m1rA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mn3 CARBON
CATABOLITE-DEREPRESS
ING PROTEIN KINASE

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		5 LEU A  61
LEU A 110
ILE A 115
TYR A 134
ILE A 193
 None
 0.69A 3zosB-3mn3A:
14.3		 3zosB-3mn3A:
29.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nuu PKB-LIKE

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A  88
MET A 134
LEU A 137
TYR A 161
ILE A 221
 JOZ  A 361 (-4.1A)
None
None
None
None
 0.80A 3zosB-3nuuA:
22.8		 3zosB-3nuuA:
25.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nzp ARGININE
DECARBOXYLASE

(Campylobacter
jejuni) 		PF02784
(Orn_Arg_deC_N) 		5 LEU A 223
ILE A 129
LEU A 116
ILE A 142
ILE A 145
 None
 1.20A 3zosB-3nzpA:
undetectable		 3zosB-3nzpA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pf2 CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN

(Streptococcus
agalactiae) 		PF16569
(GramPos_pilinBB)
PF16570
(GramPos_pilinD3) 		5 ILE A 302
LEU A 271
ILE A 264
MET A 309
ILE A 333
 None
 1.27A 3zosB-3pf2A:
undetectable		 3zosB-3pf2A:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pnr FALCIPAIN 2

(Plasmodium
falciparum) 		PF00112
(Peptidase_C1) 		5 LEU A  65
ILE A 202
LEU A 178
ILE A 146
TYR A  55
 None
 1.02A 3zosB-3pnrA:
undetectable		 3zosB-3pnrA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ps5 TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 6

(Homo sapiens) 		PF00017
(SH2)
PF00102
(Y_phosphatase) 		5 LEU A 523
ILE A 466
LEU A 469
ILE A 482
ILE A 223
 None
 1.25A 3zosB-3ps5A:
undetectable		 3zosB-3ps5A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rh9 SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(NAD(P)(+))

(Marinobacter
hydrocarbonoclasticus) 		PF00171
(Aldedh) 		5 ILE A 189
LEU A   7
ILE A   2
MET A 321
ILE A  38
 None
 1.26A 3zosB-3rh9A:
undetectable		 3zosB-3rh9A:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tac LIPRIN-ALPHA-2

(Homo sapiens) 		PF00536
(SAM_1)
PF07647
(SAM_2) 		5 ILE B 930
MET B 931
LEU B 934
ILE B 939
MET B 913
 None
 1.20A 3zosB-3tacB:
undetectable		 3zosB-3tacB:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tsd INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Bacillus
anthracis) 		PF00478
(IMPDH)
PF00571
(CBS) 		5 LEU A 454
LEU A  69
ILE A  47
MET A 350
ILE A 339
 None
 1.20A 3zosB-3tsdA:
undetectable		 3zosB-3tsdA:
21.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3tt0 BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 484
MET A 535
ILE A 544
TYR A 563
ILE A 639
 07J  A   1 ( 4.3A)
07J  A   1 (-3.8A)
None
07J  A   1 (-4.7A)
None
 0.70A 3zosB-3tt0A:
30.3		 3zosB-3tt0A:
31.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3v5q NT-3 GROWTH FACTOR
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 544
ILE A 600
MET A 615
TYR A 619
MET A 620
ILE A 695
 0F4  A 902 ( 4.2A)
0F4  A 902 (-4.1A)
None
0F4  A 902 (-4.2A)
None
0F4  A 902 (-4.6A)
 0.63A 3zosB-3v5qA:
26.7		 3zosB-3v5qA:
45.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vo2 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Zea mays) 		PF00175
(NAD_binding_1) 		5 ILE A 166
LEU A 168
ILE A 281
MET A 297
ILE A 284
 None
 1.15A 3zosB-3vo2A:
undetectable		 3zosB-3vo2A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4af3 AURORA KINASE B

(Homo sapiens) 		PF00069
(Pkinase) 		5 ILE A 128
LEU A 132
ILE A 137
TYR A 156
ILE A 216
 None
None
None
VX6  A 500 (-4.2A)
None
 1.01A 3zosB-4af3A:
19.5		 3zosB-4af3A:
26.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4at3 BDNF/NT-3 GROWTH
FACTORS RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 560
ILE A 616
MET A 631
TYR A 635
MET A 636
ILE A 708
 LTI  A1839 ( 4.2A)
None
None
LTI  A1839 (-4.7A)
None
None
 0.72A 3zosB-4at3A:
32.1		 3zosB-4at3A:
47.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cfh 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1

(Rattus
norvegicus) 		PF00069
(Pkinase)
PF16579
(AdenylateSensor) 		5 LEU A  22
ILE A  76
MET A  91
TYR A  95
ILE A 155
 STU  A1550 (-4.3A)
None
None
STU  A1550 (-4.5A)
None
 0.72A 3zosB-4cfhA:
22.4		 3zosB-4cfhA:
21.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ckr EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 LEU A 616
ILE A 675
MET A 676
LEU A 679
ILE A 684
MET A 699
TYR A 703
MET A 704
ILE A 782
 None
None
DI1  A1000 (-3.6A)
DI1  A1000 (-4.5A)
DI1  A1000 ( 4.5A)
DI1  A1000 ( 4.1A)
DI1  A1000 (-4.0A)
None
DI1  A1000 (-4.5A)
 0.54A 3zosB-4ckrA:
43.7		 3zosB-4ckrA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eqm PROTEIN KINASE

(Staphylococcus
aureus) 		PF00069
(Pkinase) 		5 LEU A  16
LEU A  65
ILE A  70
TYR A  89
ILE A 149
 ANP  A 300 (-4.7A)
None
None
ANP  A 300 (-4.3A)
None
 0.71A 3zosB-4eqmA:
22.3		 3zosB-4eqmA:
26.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f0g SERINE/THREONINE-PRO
TEIN KINASE ROCO4

(Dictyostelium
discoideum) 		PF07714
(Pkinase_Tyr) 		5 ILE A1081
MET A1082
LEU A1085
ILE A1090
MET A1103
 None
 0.77A 3zosB-4f0gA:
19.6		 3zosB-4f0gA:
29.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4f0i HIGH AFFINITY NERVE
GROWTH FACTOR
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 515
ILE A 571
MET A 586
TYR A 590
MET A 591
ILE A 665
 None
 0.74A 3zosB-4f0iA:
33.5		 3zosB-4f0iA:
44.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f4f THREONINE SYNTHASE

(Brucella
melitensis) 		PF00291
(PALP)
PF14821
(Thr_synth_N) 		5 LEU A 383
ILE A 310
LEU A 286
ILE A 278
ILE A 260
 None
 1.13A 3zosB-4f4fA:
undetectable		 3zosB-4f4fA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4flx DNA POLYMERASE 1

(Pyrococcus
abyssi) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		5 LEU A 322
ILE A 198
LEU A 194
ILE A 160
ILE A 142
 LEU  A 322 ( 0.6A)
ILE  A 198 ( 0.7A)
LEU  A 194 ( 0.5A)
ILE  A 160 ( 0.7A)
ILE  A 142 (-0.7A)
 1.25A 3zosB-4flxA:
undetectable		 3zosB-4flxA:
18.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4fod ALK TYROSINE KINASE
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A1122
ILE A1170
ILE A1179
MET A1199
ILE A1268
 0UV  A1501 (-3.8A)
None
None
None
None
 0.82A 3zosB-4fodA:
23.5		 3zosB-4fodA:
34.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fr4 SERINE/THREONINE-PRO
TEIN KINASE 32A

(Homo sapiens) 		PF00069
(Pkinase) 		5 ILE A  74
MET A  75
LEU A  78
MET A  98
ILE A 162
 None
 1.08A 3zosB-4fr4A:
20.7		 3zosB-4fr4A:
23.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4gl9 TYROSINE-PROTEIN
KINASE

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		5 LEU A 855
ILE A 901
ILE A 910
TYR A 931
ILE A 992
 IZA  A2001 (-3.7A)
None
None
None
None
 0.69A 3zosB-4gl9A:
28.3		 3zosB-4gl9A:
33.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4gl9 TYROSINE-PROTEIN
KINASE

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		5 LEU A 855
ILE A 901
LEU A 905
ILE A 910
ILE A 992
 IZA  A2001 (-3.7A)
None
None
None
None
 0.71A 3zosB-4gl9A:
28.3		 3zosB-4gl9A:
33.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hpf POTASSIUM CHANNEL
SUBFAMILY U MEMBER 1

(Homo sapiens) 		PF03493
(BK_channel_a) 		5 LEU A 367
ILE A 472
LEU A 458
ILE A 430
MET A 395
 None
 1.16A 3zosB-4hpfA:
undetectable		 3zosB-4hpfA:
18.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hvi TYROSINE-PROTEIN
KINASE JAK3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 828
ILE A 874
LEU A 878
ILE A 883
TYR A 904
ILE A 965
 19S  A1201 (-3.9A)
None
None
None
19S  A1201 (-4.7A)
None
 0.66A 3zosB-4hviA:
29.2		 3zosB-4hviA:
33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4k33 FIBROBLAST GROWTH
FACTOR RECEPTOR 3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 478
MET A 529
ILE A 538
TYR A 557
ILE A 633
 ACP  A 801 (-3.8A)
None
None
None
None
 0.67A 3zosB-4k33A:
6.1		 3zosB-4k33A:
34.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mvf CALCIUM-DEPENDENT
PROTEIN KINASE 2

(Plasmodium
falciparum) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		5 ILE A 120
MET A 121
LEU A 124
ILE A 129
ILE A 211
 None
 0.79A 3zosB-4mvfA:
19.5		 3zosB-4mvfA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 903
ILE A 950
ILE A 959
TYR A 980
ILE A1039
 2TT  A1202 (-3.5A)
None
None
2TT  A1202 (-4.6A)
None
 0.58A 3zosB-4oliA:
26.3		 3zosB-4oliA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 903
ILE A 950
LEU A 954
ILE A 959
ILE A1039
 2TT  A1202 (-3.5A)
None
None
None
None
 0.74A 3zosB-4oliA:
26.3		 3zosB-4oliA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qlz SJCHGC07024 PROTEIN

(Schistosoma
japonicum) 		PF00719
(Pyrophosphatase) 		5 LEU A  32
ILE A 169
ILE A 122
MET A  43
ILE A 156
 None
 1.22A 3zosB-4qlzA:
undetectable		 3zosB-4qlzA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rd8 UNCHARACTERIZED
PROTEIN

(Legionella
pneumophila) 		no annotation 5 LEU A  99
ILE A 131
ILE A 182
MET A  90
MET A 105
 None
 1.26A 3zosB-4rd8A:
undetectable		 3zosB-4rd8A:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4red 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A  24
ILE A  78
MET A  93
TYR A  97
ILE A 157
 None
 0.73A 3zosB-4redA:
13.9		 3zosB-4redA:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rew 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1

(Homo sapiens) 		PF00069
(Pkinase)
PF16579
(AdenylateSensor) 		5 LEU A  24
ILE A  78
MET A  93
TYR A  97
ILE A 157
 STU  A 601 (-3.7A)
None
None
STU  A 601 (-4.4A)
None
 0.63A 3zosB-4rewA:
22.2		 3zosB-4rewA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rxt SUGAR ABC
TRANSPORTER

(Agrobacterium
tumefaciens) 		PF13407
(Peripla_BP_4) 		5 LEU A  63
LEU A  70
ILE A  40
TYR A 284
ILE A  96
 None
 1.21A 3zosB-4rxtA:
undetectable		 3zosB-4rxtA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wbo RHODOPSIN KINASE

(Bos taurus) 		PF00069
(Pkinase)
PF00615
(RGS) 		5 LEU A 193
ILE A 238
ILE A 247
MET A 267
ILE A 330
 ANW  A 601 ( 4.0A)
None
None
None
None
 1.01A 3zosB-4wboA:
21.9		 3zosB-4wboA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4znj PHAGE TERMINASE
LARGE SUBUNIT

(Thermus virus
P74-26) 		PF03237
(Terminase_6) 		5 LEU A  87
ILE A  25
LEU A 175
ILE A 147
ILE A  76
 None
 1.23A 3zosB-4znjA:
undetectable		 3zosB-4znjA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zxi TYROCIDINE
SYNTHETASE 3

(Acinetobacter
baumannii) 		PF00501
(AMP-binding)
PF00550
(PP-binding)
PF00668
(Condensation)
PF00975
(Thioesterase)
PF13193
(AMP-binding_C) 		5 LEU A 736
ILE A 485
MET A 681
ILE A 643
ILE A 642
 None
 1.26A 3zosB-4zxiA:
undetectable		 3zosB-4zxiA:
14.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 484
MET A 535
ILE A 544
TYR A 563
ILE A 639
 38O  A1769 (-3.2A)
EDO  A1766 (-3.5A)
None
38O  A1769 (-4.2A)
None
 0.76A 3zosB-5a46A:
30.6		 3zosB-5a46A:
31.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bpt MGC81278 PROTEIN

(Xenopus laevis) 		PF12894
(ANAPC4_WD40)
PF12896
(ANAPC4) 		5 LEU A 530
ILE A  72
LEU A  94
ILE A 148
ILE A 157
 None
 1.28A 3zosB-5bptA:
2.1		 3zosB-5bptA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dm4 METHYLTRANSFERASE
DOMAIN FAMILY

(Bacillus
pumilus) 		PF13489
(Methyltransf_23) 		5 LEU A 134
ILE A 201
LEU A 254
ILE A 155
ILE A 126
 SAH  A 300 ( 4.3A)
None
None
None
None
 1.26A 3zosB-5dm4A:
undetectable		 3zosB-5dm4A:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5es1 MAP/MICROTUBULE
AFFINITY-REGULATING
KINASE 4

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		5 ILE A 106
LEU A 110
ILE A 115
TYR A 134
ILE A 194
 None
None
None
5RC  A4000 (-4.5A)
None
 0.83A 3zosB-5es1A:
22.5		 3zosB-5es1A:
25.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ILE A 950
LEU A 954
ILE A 959
TYR A 980
ILE A1039
 None
None
None
5U3  A1200 (-4.5A)
None
 0.73A 3zosB-5f1zA:
27.1		 3zosB-5f1zA:
34.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 903
ILE A 950
ILE A 959
TYR A 980
ILE A1039
 5U3  A1200 (-3.8A)
None
None
5U3  A1200 (-4.5A)
None
 0.46A 3zosB-5f1zA:
27.1		 3zosB-5f1zA:
34.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 599
ILE A 647
MET A 648
ILE A 657
TYR A 676
ILE A 834
 748  A1001 (-3.8A)
748  A1001 ( 4.0A)
748  A1001 (-3.4A)
748  A1001 ( 4.4A)
748  A1001 (-4.0A)
748  A1001 (-4.8A)
 0.84A 3zosB-5grnA:
28.1		 3zosB-5grnA:
30.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i3o BMP-2-INDUCIBLE
PROTEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A  57
ILE A  98
MET A  99
ILE A 108
TYR A 132
 IDV  A 401 (-3.8A)
None
None
None
IDV  A 401 (-3.5A)
 0.95A 3zosB-5i3oA:
21.6		 3zosB-5i3oA:
26.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ig1 CAMK/CAMK2 PROTEIN
KINASE

(Salpingoeca
rosetta) 		PF00069
(Pkinase) 		5 ILE A  68
LEU A  72
ILE A  77
TYR A  96
ILE A 159
 None
None
None
PO4  A 401 (-4.8A)
None
 0.74A 3zosB-5ig1A:
23.2		 3zosB-5ig1A:
26.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iso 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2

(Homo sapiens) 		PF00069
(Pkinase)
PF16579
(AdenylateSensor) 		5 LEU A  22
ILE A  76
MET A  91
TYR A  95
ILE A 155
 STU  A 601 (-4.1A)
None
None
STU  A 601 (-4.3A)
None
 0.71A 3zosB-5isoA:
22.6		 3zosB-5isoA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5of4 GENERAL
TRANSCRIPTION FACTOR
IIH SUBUNIT 2
TFIIH BASAL
TRANSCRIPTION FACTOR
COMPLEX HELICASE XPD
SUBUNIT

(Homo sapiens) 		PF04056
(Ssl1)
PF06733
(DEAD_2)
PF06777
(HBB)
PF13307
(Helicase_C_2) 		5 ILE E 169
LEU E 145
ILE E 182
TYR B 614
ILE E 186
 None
 1.27A 3zosB-5of4E:
undetectable		 3zosB-5of4E:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u8s DNA REPLICATION
LICENSING FACTOR
MCM4

(Saccharomyces
cerevisiae) 		PF00493
(MCM)
PF14551
(MCM_N)
PF17207
(MCM_OB) 		5 ILE 4 829
LEU 4 704
ILE 4 564
MET 4 649
ILE 4 562
 None
 1.15A 3zosB-5u8s4:
2.3		 3zosB-5u8s4:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uuw INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Bacillus
anthracis) 		PF00478
(IMPDH) 		5 LEU A 454
LEU A  69
ILE A  47
MET A 350
ILE A 339
 None
 1.21A 3zosB-5uuwA:
undetectable		 3zosB-5uuwA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w4l ANTIBODY N12-I3 FAB
HEAVY CHAIN

(Homo sapiens) 		no annotation 5 LEU D  45
ILE D  52
ILE D  69
TYR D  91
ILE D  67
 None
 1.29A 3zosB-5w4lD:
undetectable		 3zosB-5w4lD:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w5j RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2

(Homo sapiens) 		no annotation 5 LEU A  24
ILE A  78
TYR A  97
MET A  98
ILE A 162
 9WS  A 401 ( 4.2A)
None
None
None
None
 0.47A 3zosB-5w5jA:
22.2		 3zosB-5w5jA:
27.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w5j RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2

(Homo sapiens) 		no annotation 5 LEU A  24
ILE A 162
TYR A  97
MET A  98
ILE A 152
 9WS  A 401 ( 4.2A)
None
None
None
None
 0.83A 3zosB-5w5jA:
22.2		 3zosB-5w5jA:
27.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wnm RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 4

(Mus musculus) 		no annotation 5 MET A  73
ILE A  81
TYR A  98
MET A  99
ILE A 159
 None
None
VX6  A 402 (-4.3A)
None
None
 0.72A 3zosB-5wnmA:
26.0		 3zosB-5wnmA:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xu1 ABC TRANSPORTER
ATP-BINDING PROTEIN

(Streptococcus
pneumoniae) 		no annotation 5 ILE A 183
LEU A 187
ILE A 197
MET A  51
ILE A 166
 None
 1.21A 3zosB-5xu1A:
undetectable		 3zosB-5xu1A:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xwy A TYPE VI-A
CRISPR-CAS
RNA-GUIDED RNA
RIBONUCLEASE, CAS13A

(Leptotrichia
buccalis) 		no annotation 5 LEU A 596
ILE A 550
ILE A 681
TYR A 560
ILE A 684
 None
 1.09A 3zosB-5xwyA:
undetectable		 3zosB-5xwyA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bx6 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2

(Homo sapiens) 		no annotation 5 LEU A  22
ILE A  76
MET A  91
TYR A  95
ILE A 155
 EDJ  A 301 (-3.9A)
None
None
EDJ  A 301 ( 4.8A)
None
 0.45A 3zosB-6bx6A:
18.8		 3zosB-6bx6A:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c6k INTERFERON-INDUCED
PROTEIN WITH
TETRATRICOPEPTIDE
REPEATS 1

(Homo sapiens) 		no annotation 5 LEU A 459
ILE A 401
LEU A 405
ILE A 408
ILE A 421
 None
 1.28A 3zosB-6c6kA:
undetectable		 3zosB-6c6kA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c7y TYROSINE-PROTEIN
KINASE JAK1

(Homo sapiens) 		no annotation 5 LEU A 881
ILE A 928
LEU A 932
ILE A 937
ILE A1019
 ADP  A1201 ( 4.5A)
None
None
None
None
 0.71A 3zosB-6c7yA:
20.0		 3zosB-6c7yA:
12.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c9d SERINE/THREONINE-PRO
TEIN KINASE
MARK1,SERINE/THREONI
NE-PROTEIN KINASE
MARK1

(Homo sapiens) 		no annotation 5 ILE A 110
LEU A 114
ILE A 119
TYR A 138
ILE A 198
 None
 0.80A 3zosB-6c9dA:
21.2		 3zosB-6c9dA:
11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c9d SERINE/THREONINE-PRO
TEIN KINASE
MARK1,SERINE/THREONI
NE-PROTEIN KINASE
MARK1

(Homo sapiens) 		no annotation 5 ILE A 110
MET A 111
ILE A 119
TYR A 138
ILE A 198
 None
 0.98A 3zosB-6c9dA:
21.2		 3zosB-6c9dA:
11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f5d ATP SYNTHASE SUBUNIT
BETA

(Trypanosoma
brucei) 		no annotation 5 LEU D 150
ILE D 309
LEU D 258
ILE D 260
ILE D 263
 None
 1.16A 3zosB-6f5dD:
undetectable		 3zosB-6f5dD:
12.18