SIMILAR PATTERNS OF AMINO ACIDS FOR 3ZOS_A_0LIA1004_1

	Hit	Macromolecule/ Organism	Pfam	Res.	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)	View	Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1a5i	PLASMINOGEN ACTIVATOR (Desmodus rotundus)	PF00089 (Trypsin)	5	VAL A 118 ALA A 112 LEU A  68 GLY A  44 ILE A  24	None	1.03A	3zosA-1a5iA: 0.0 3zosB-1a5iA: 0.0	3zosA-1a5iA: 19.14 3zosB-1a5iA: 19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1dof	ADENYLOSUCCINATE LYASE (Pyrobaculum aerophilum)	PF00206 (Lyase_1)	5	VAL A 202 ALA A  38 LEU A  35 VAL A  44 GLY A 195	None	0.93A	3zosA-1dofA: 0.6 3zosB-1dofA: 0.6	3zosA-1dofA: 22.54 3zosB-1dofA: 22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1e6y	METHYL-COENZYME M REDUCTASE SUBUNIT ALPHA (Methanosarcina barkeri)	PF02249 (MCR_alpha) PF02745 (MCR_alpha_N)	5	LEU A1327 GLY A1506 ILE A1303 VAL A1431 GLY A1322	None	1.07A	3zosA-1e6yA: 0.0 3zosB-1e6yA: 0.0	3zosA-1e6yA: 20.67 3zosB-1e6yA: 20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1f8f	BENZYL ALCOHOL DEHYDROGENASE (Acinetobacter calcoaceticus)	PF00107 (ADH_zinc_N) PF08240 (ADH_N)	5	ALA A  61 LEU A  63 ILE A 351 LEU A  59 GLY A  16	None	1.05A	3zosA-1f8fA: 0.0 3zosB-1f8fA: 0.0	3zosA-1f8fA: 21.39 3zosB-1f8fA: 21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1fzt	PHOSPHOGLYCERATE MUTASE (Schizosaccharomyces pombe)	PF00300 (His_Phos_1)	5	ALA A 161 GLY A  46 ILE A  39 VAL A  11 LEU A 159	None	0.89A	3zosA-1fztA: 0.0 3zosB-1fztA: undetectable	3zosA-1fztA: 20.81 3zosB-1fztA: 20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1hr7	MITOCHONDRIAL PROCESSING PEPTIDASE ALPHA SUBUNIT (Saccharomyces cerevisiae)	PF00675 (Peptidase_M16) PF05193 (Peptidase_M16_C)	5	ALA A 348 VAL A 456 LEU A 460 GLY A 262 PHE A 263	None	1.04A	3zosA-1hr7A: 0.0 3zosB-1hr7A: 0.0	3zosA-1hr7A: 20.12 3zosB-1hr7A: 20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1ibq	ASPERGILLOPEPSIN (Aspergillus phoenicis)	PF00026 (Asp)	5	ALA A 266 LEU A 219 GLY A 301 ILE A 273 VAL A 310	None	0.93A	3zosA-1ibqA: 0.0 3zosB-1ibqA: 0.0	3zosA-1ibqA: 23.29 3zosB-1ibqA: 23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1ize	ASPARTIC PROTEINASE (Aspergillus oryzae)	PF00026 (Asp)	5	ALA A 266 LEU A 219 GLY A 299 ILE A 273 VAL A 308	None	1.04A	3zosA-1izeA: 0.0 3zosB-1izeA: 0.0	3zosA-1izeA: 22.13 3zosB-1izeA: 22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1ize	ASPARTIC PROTEINASE (Aspergillus oryzae)	PF00026 (Asp)	5	VAL A 268 LEU A 219 GLY A 299 ILE A 273 VAL A 308	None	1.05A	3zosA-1izeA: 0.0 3zosB-1izeA: 0.0	3zosA-1izeA: 22.13 3zosB-1izeA: 22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1jtd	BETA-LACTAMASE INHIBITOR PROTEIN II (Streptomyces exfoliatus)	PF13540 (RCC1_2)	5	VAL B 225 ALA B 185 PHE B 230 VAL B 162 GLY B 188	None None None None CA  B 502 (-4.3A)	1.08A	3zosA-1jtdB: undetectable 3zosB-1jtdB: 0.0	3zosA-1jtdB: 22.39 3zosB-1jtdB: 22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1ps6	4-HYDROXYTHREONINE-4 -PHOSPHATE DEHYDROGENASE (Escherichia coli)	PF04166 (PdxA)	5	ALA A  38 LEU A  42 GLY A  16 VAL A  97 GLY A  18	None	0.76A	3zosA-1ps6A: undetectable 3zosB-1ps6A: undetectable	3zosA-1ps6A: 25.14 3zosB-1ps6A: 25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1rwr	FILAMENTOUS HEMAGGLUTININ (Bordetella pertussis)	PF05860 (Haemagg_act)	5	LEU A 232 GLY A 219 ILE A 261 VAL A 173 GLY A 245	None	1.13A	3zosA-1rwrA: undetectable 3zosB-1rwrA: undetectable	3zosA-1rwrA: 21.70 3zosB-1rwrA: 21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1sj7	TALIN 1 (Mus musculus)	PF09141 (Talin_middle)	5	ALA A 616 LEU A 513 LEU A 594 GLY A 590 LEU A 584	None	1.10A	3zosA-1sj7A: undetectable 3zosB-1sj7A: undetectable	3zosA-1sj7A: 18.01 3zosB-1sj7A: 18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1uuf	ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN YAHK (Escherichia coli)	PF00107 (ADH_zinc_N) PF08240 (ADH_N)	5	ALA A 213 LEU A 217 GLY A 187 PHE A 240 GLY A 182	None	1.17A	3zosA-1uufA: undetectable 3zosB-1uufA: undetectable	3zosA-1uufA: 22.25 3zosB-1uufA: 22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1uuo	DIHYDROOROTATE DEHYDROGENASE (Rattus rattus)	PF01180 (DHO_dh)	5	VAL A  60 ALA A 104 GLY A  97 VAL A 116 LEU A 108	None None FMN  A1398 (-3.0A) None None	1.16A	3zosA-1uuoA: undetectable 3zosB-1uuoA: undetectable	3zosA-1uuoA: 22.51 3zosB-1uuoA: 22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1vaj	HYPOTHETICAL PROTEIN PH0010 (Pyrococcus horikoshii)	PF01871 (AMMECR1)	5	ALA A 188 LEU A 147 GLY A  67 ILE A 136 VAL A 108	None	1.10A	3zosA-1vajA: undetectable 3zosB-1vajA: undetectable	3zosA-1vajA: 21.60 3zosB-1vajA: 21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1vbf	231AA LONG HYPOTHETICAL PROTEIN-L-ISOASPARTA TE O-METHYLTRANSFERASE (Sulfurisphaera tokodaii)	PF01135 (PCMT)	5	VAL A 139 GLY A  59 ILE A  88 VAL A 191 LEU A 173	None	1.17A	3zosA-1vbfA: undetectable 3zosB-1vbfA: undetectable	3zosA-1vbfA: 20.70 3zosB-1vbfA: 20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1wwk	PHOSPHOGLYCERATE DEHYDROGENASE (Pyrococcus horikoshii)	PF00389 (2-Hacid_dh) PF02826 (2-Hacid_dh_C)	5	VAL A 154 ALA A 101 GLY A 146 ILE A 165 GLY A 148	None None NAD  A1001 (-3.5A) None NAD  A1001 (-3.2A)	1.08A	3zosA-1wwkA: undetectable 3zosB-1wwkA: undetectable	3zosA-1wwkA: 23.71 3zosB-1wwkA: 23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1wxd	SHIKIMATE 5-DEHYDROGENASE (Thermus thermophilus)	PF01488 (Shikimate_DH) PF08501 (Shikimate_dh_N)	5	ALA A 138 LEU A 140 LEU A 175 PHE A 196 LEU A 105	None	1.14A	3zosA-1wxdA: undetectable 3zosB-1wxdA: undetectable	3zosA-1wxdA: 23.78 3zosB-1wxdA: 23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1xfg	GLUCOSAMINE--FRUCTOS E-6-PHOSPHATE AMINOTRANSFERASE [ISOMERIZING] (Escherichia coli)	PF13522 (GATase_6)	5	VAL A  35 ALA A  13 LEU A  63 LEU A  17 GLY A  32	None	1.11A	3zosA-1xfgA: undetectable 3zosB-1xfgA: undetectable	3zosA-1xfgA: 22.96 3zosB-1xfgA: 22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1ym0	FIBRINOTIC ENZYME COMPONENT B (Eisenia fetida)	PF00089 (Trypsin)	5	VAL A 231 LEU A 209 GLY A 197 ILE A 181 VAL A  52	None	1.09A	3zosA-1ym0A: undetectable 3zosB-1ym0A: undetectable	3zosA-1ym0A: 20.12 3zosB-1ym0A: 20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1yxo	4-HYDROXYTHREONINE-4 -PHOSPHATE DEHYDROGENASE 1 (Pseudomonas aeruginosa)	PF04166 (PdxA)	5	ALA A1036 LEU A1040 GLY A1014 VAL A1096 GLY A1016	None	0.78A	3zosA-1yxoA: undetectable 3zosB-1yxoA: undetectable	3zosA-1yxoA: 24.22 3zosB-1yxoA: 24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1zj9	PROBABLE FERREDOXIN-DEPENDENT NITRITE REDUCTASE NIRA (Mycobacterium tuberculosis)	PF01077 (NIR_SIR) PF03460 (NIR_SIR_ferr)	5	ALA A 549 GLY A 508 LEU A 554 GLY A 498 PHE A 542	None	1.03A	3zosA-1zj9A: undetectable 3zosB-1zj9A: undetectable	3zosA-1zj9A: 20.35 3zosB-1zj9A: 20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1zmr	PHOSPHOGLYCERATE KINASE (Escherichia coli)	PF00162 (PGK)	5	VAL A 229 ALA A 223 LEU A 284 GLY A 215 PHE A 315	None	1.18A	3zosA-1zmrA: undetectable 3zosB-1zmrA: undetectable	3zosA-1zmrA: 21.89 3zosB-1zmrA: 21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2a38	TITIN (Homo sapiens)	PF07679 (I-set)	5	VAL A  37 ALA A  82 LEU A  80 ILE A  56 GLY A  61	None	0.94A	3zosA-2a38A: undetectable 3zosB-2a38A: undetectable	3zosA-2a38A: 18.99 3zosB-2a38A: 18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2aif	RIBOSOMAL PROTEIN L7A (Cryptosporidium parvum)	PF01248 (Ribosomal_L7Ae)	5	VAL A 104 ALA A 107 LEU A  94 LEU A  40 GLY A  99	None	1.14A	3zosA-2aifA: undetectable 3zosB-2aifA: undetectable	3zosA-2aifA: 20.20 3zosB-2aifA: 20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2axq	SACCHAROPINE DEHYDROGENASE (Saccharomyces cerevisiae)	PF03435 (Sacchrp_dh_NADP) PF16653 (Sacchrp_dh_C)	5	VAL A  95 GLY A 123 ILE A 411 VAL A  13 LEU A  74	None	1.16A	3zosA-2axqA: undetectable 3zosB-2axqA: undetectable	3zosA-2axqA: 20.84 3zosB-2axqA: 20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2bej	SEGREGATION PROTEIN (Thermus thermophilus)	PF13614 (AAA_31)	5	ALA A  92 LEU A  96 LEU A 123 VAL A  61 LEU A  89	None	1.18A	3zosA-2bejA: undetectable 3zosB-2bejA: undetectable	3zosA-2bejA: 26.14 3zosB-2bejA: 26.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2bru	NAD(P) TRANSHYDROGENASE SUBUNIT ALPHA (Escherichia coli)	PF01262 (AlaDh_PNT_C) PF05222 (AlaDh_PNT_N)	5	VAL A1253 LEU A1257 GLY A1174 VAL A1204 GLY A1172	None	0.89A	3zosA-2bruA: undetectable 3zosB-2bruA: undetectable	3zosA-2bruA: 21.28 3zosB-2bruA: 21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2ch1	3-HYDROXYKYNURENINE TRANSAMINASE (Anopheles gambiae)	PF00266 (Aminotran_5)	5	ALA A 267 LEU A 184 GLY A 202 ILE A 275 PHE A 189	None	1.11A	3zosA-2ch1A: undetectable 3zosB-2ch1A: undetectable	3zosA-2ch1A: 22.09 3zosB-2ch1A: 22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2dyk	GTP-BINDING PROTEIN (Thermus thermophilus)	PF01926 (MMR_HSR1)	5	VAL A  87 ALA A 115 LEU A 113 GLY A 132 LEU A 127	None	1.05A	3zosA-2dykA: undetectable 3zosB-2dykA: undetectable	3zosA-2dykA: 21.07 3zosB-2dykA: 21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2gh9	MALTOSE/MALTODEXTRIN -BINDING PROTEIN (Thermus thermophilus)	PF13416 (SBP_bac_8)	5	VAL A 254 ALA A 258 PHE A 329 VAL A 191 GLY A 161	None	1.06A	3zosA-2gh9A: undetectable 3zosB-2gh9A: undetectable	3zosA-2gh9A: 24.33 3zosB-2gh9A: 24.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2j6h	GLUCOSAMINE-FRUCTOSE -6-PHOSPHATE AMINOTRANSFERASE (Escherichia coli)	PF01380 (SIS) PF13522 (GATase_6)	5	VAL A  35 ALA A  13 LEU A  63 LEU A  17 GLY A  32	None	1.11A	3zosA-2j6hA: undetectable 3zosB-2j6hA: undetectable	3zosA-2j6hA: 19.41 3zosB-2j6hA: 19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2kma	TALIN 1 (Mus musculus)	PF09379 (FERM_N) PF16511 (FERM_f0)	5	VAL A 102 LEU A  88 LEU A 193 VAL A 185 LEU A 180	None	1.10A	3zosA-2kmaA: undetectable 3zosB-2kmaA: undetectable	3zosA-2kmaA: 21.24 3zosB-2kmaA: 21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2og9	MANDELATE RACEMASE/MUCONATE LACTONIZING ENZYME (Polaromonas sp. JS666)	PF02746 (MR_MLE_N) PF13378 (MR_MLE_C)	5	ALA A  80 LEU A 129 ILE A  15 LEU A  50 GLY A  64	None	1.16A	3zosA-2og9A: undetectable 3zosB-2og9A: undetectable	3zosA-2og9A: 24.21 3zosB-2og9A: 24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2ohh	TYPE A FLAVOPROTEIN FPRA (Methanothermobacter thermautotrophicus)	PF00258 (Flavodoxin_1) PF00753 (Lactamase_B)	5	LEU A 160 LEU A  39 GLY A  11 ILE A  49 GLY A  42	None	1.14A	3zosA-2ohhA: undetectable 3zosB-2ohhA: undetectable	3zosA-2ohhA: 21.63 3zosB-2ohhA: 21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2p2v	ALPHA-2,3-SIALYLTRAN SFERASE (Campylobacter jejuni)	PF06002 (CST-I)	5	LEU A 211 GLY A 148 ILE A 156 PHE A  92 LEU A 231	None CSF  A1001 (-3.8A) None None None	1.14A	3zosA-2p2vA: undetectable 3zosB-2p2vA: undetectable	3zosA-2p2vA: 18.73 3zosB-2p2vA: 18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2qkx	BIFUNCTIONAL PROTEIN GLMU (Mycobacterium tuberculosis)	PF00132 (Hexapep) PF12804 (NTP_transf_3)	5	VAL A  27 ALA A  13 LEU A  37 VAL A  80 LEU A  56	None	0.98A	3zosA-2qkxA: undetectable 3zosB-2qkxA: undetectable	3zosA-2qkxA: 22.94 3zosB-2qkxA: 22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2ru4	ARMADILLO REPEAT PROTEIN, C-TERMINAL FRAGMENT, MAII ARMADILLO REPEAT PROTEIN, N-TERMINAL FRAGMENT, YIIM2 (synthetic construct)	PF00514 (Arm) PF16186 (Arm_3)	5	ALA B 150 LEU A 109 ILE A  82 LEU B 132 GLY B 127	None	0.96A	3zosA-2ru4B: undetectable 3zosB-2ru4B: undetectable	3zosA-2ru4B: 15.03 3zosB-2ru4B: 15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2vdc	GLUTAMATE SYNTHASE [NADPH] LARGE CHAIN (Azospirillum brasilense)	PF00310 (GATase_2) PF01493 (GXGXG) PF01645 (Glu_synthase) PF04898 (Glu_syn_central)	5	ALA A  44 LEU A 333 VAL A  28 LEU A  25 GLY A   4	None	1.15A	3zosA-2vdcA: undetectable 3zosB-2vdcA: undetectable	3zosA-2vdcA: 12.59 3zosB-2vdcA: 12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2xvg	ALPHA XYLOSIDASE (Cellvibrio japonicus)	PF01055 (Glyco_hydro_31) PF16338 (DUF4968) PF17137 (DUF5110)	5	ALA A 125 LEU A 130 GLY A 132 VAL A  80 LEU A  70	None	1.04A	3zosA-2xvgA: undetectable 3zosB-2xvgA: undetectable	3zosA-2xvgA: 16.37 3zosB-2xvgA: 16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2y2w	ARABINOFURANOSIDASE (Bifidobacterium longum)	PF06964 (Alpha-L-AF_C)	5	VAL A 317 ALA A 321 LEU A 336 LEU A 271 GLY A 254	None	1.16A	3zosA-2y2wA: 2.0 3zosB-2y2wA: undetectable	3zosA-2y2wA: 19.61 3zosB-2y2wA: 19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3a64	CELLOBIOHYDROLASE (Coprinopsis cinerea)	PF01341 (Glyco_hydro_6)	5	GLY A 283 ILE A 290 VAL A  53 LEU A 379 GLY A 306	None	1.05A	3zosA-3a64A: undetectable 3zosB-3a64A: undetectable	3zosA-3a64A: 24.32 3zosB-3a64A: 24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3ahi	XYLULOSE 5-PHOSPHATE/FRUCTOSE 6-PHOSPHATE PHOSPHOKETOLASE (Bifidobacterium breve)	PF03894 (XFP) PF09363 (XFP_C) PF09364 (XFP_N)	5	ALA A 327 LEU A 337 GLY A  38 VAL A 322 LEU A  61	None	0.88A	3zosA-3ahiA: undetectable 3zosB-3ahiA: undetectable	3zosA-3ahiA: 15.91 3zosB-3ahiA: 15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3dj4	BIFUNCTIONAL PROTEIN GLMU (Mycobacterium tuberculosis)	PF00132 (Hexapep) PF12804 (NTP_transf_3)	5	VAL A  27 ALA A  13 LEU A  37 VAL A  80 LEU A  56	None UD1  A4000 (-4.8A) None None None	1.01A	3zosA-3dj4A: undetectable 3zosB-3dj4A: undetectable	3zosA-3dj4A: 21.78 3zosB-3dj4A: 21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3dqz	ALPHA-HYDROXYNITRILE LYASE-LIKE PROTEIN (Arabidopsis thaliana)	PF12697 (Abhydrolase_6)	5	LEU A 108 GLY A  84 ILE A 216 PHE A 223 GLY A  79	None	1.15A	3zosA-3dqzA: undetectable 3zosB-3dqzA: undetectable	3zosA-3dqzA: 20.36 3zosB-3dqzA: 20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3gdo	UNCHARACTERIZED OXIDOREDUCTASE YVAA (Bacillus subtilis)	PF01408 (GFO_IDH_MocA) PF02894 (GFO_IDH_MocA_C)	5	VAL A  52 ALA A  59 GLY A  25 VAL A  16 GLY A  30	None	1.17A	3zosA-3gdoA: undetectable 3zosB-3gdoA: undetectable	3zosA-3gdoA: 22.80 3zosB-3gdoA: 22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3gra	TRANSCRIPTIONAL REGULATOR, ARAC FAMILY (Pseudomonas putida)	PF01965 (DJ-1_PfpI)	5	VAL A 143 ALA A 141 LEU A 118 LEU A 180 GLY A 130	None	0.98A	3zosA-3graA: undetectable 3zosB-3graA: undetectable	3zosA-3graA: 23.08 3zosB-3graA: 23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3jv7	ADH-A (Rhodococcus ruber)	PF00107 (ADH_zinc_N) PF08240 (ADH_N)	5	ALA A 197 GLY A 264 ILE A 231 LEU A 169 PHE A 244	None	0.92A	3zosA-3jv7A: undetectable 3zosB-3jv7A: undetectable	3zosA-3jv7A: 23.80 3zosB-3jv7A: 23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3ksx	NITRATE TRANSPORT PROTEIN (Xanthomonas citri)	PF09084 (NMT1)	5	ALA A  45 LEU A 235 GLY A  83 VAL A  39 GLY A  34	None None None MPO  A 325 ( 4.9A) None	1.13A	3zosA-3ksxA: undetectable 3zosB-3ksxA: 1.1	3zosA-3ksxA: 22.79 3zosB-3ksxA: 22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3ll3	GLUCONATE KINASE (Lactobacillus acidophilus)	PF00370 (FGGY_N) PF02782 (FGGY_C)	5	LEU A 378 GLY A 297 VAL A 407 LEU A 402 GLY A 258	None None None None ATP  A1760 (-3.1A)	0.96A	3zosA-3ll3A: undetectable 3zosB-3ll3A: undetectable	3zosA-3ll3A: 21.05 3zosB-3ll3A: 21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3lxy	4-HYDROXYTHREONINE-4 -PHOSPHATE DEHYDROGENASE (Yersinia pestis)	PF04166 (PdxA)	5	ALA A  39 LEU A  43 GLY A  17 VAL A  98 GLY A  19	None	0.81A	3zosA-3lxyA: undetectable 3zosB-3lxyA: undetectable	3zosA-3lxyA: 22.47 3zosB-3lxyA: 22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3m6c	60 KDA CHAPERONIN 1 (Mycobacterium tuberculosis)	PF00118 (Cpn60_TCP1)	5	GLY A 190 VAL A 293 LEU A 290 GLY A 192 PHE A 193	None	1.11A	3zosA-3m6cA: undetectable 3zosB-3m6cA: undetectable	3zosA-3m6cA: 22.78 3zosB-3m6cA: 22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3m6c	60 KDA CHAPERONIN 1 (Mycobacterium tuberculosis)	PF00118 (Cpn60_TCP1)	5	LEU A 290 GLY A 192 PHE A 187 VAL A 274 LEU A 246	None	1.15A	3zosA-3m6cA: undetectable 3zosB-3m6cA: undetectable	3zosA-3m6cA: 22.78 3zosB-3m6cA: 22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3ntd	FAD-DEPENDENT PYRIDINE NUCLEOTIDE-DISULPHID E OXIDOREDUCTASE (Shewanella loihica)	PF00581 (Rhodanese) PF02852 (Pyr_redox_dim) PF07992 (Pyr_redox_2)	5	GLY A  12 ILE A   4 PHE A  71 VAL A 305 GLY A 328	FAD  A 900 (-3.6A) None COA  A 901 ( 4.9A) None None	0.98A	3zosA-3ntdA: undetectable 3zosB-3ntdA: undetectable	3zosA-3ntdA: 22.18 3zosB-3ntdA: 22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3nx3	ACETYLORNITHINE AMINOTRANSFERASE (Campylobacter jejuni)	PF00202 (Aminotran_3)	5	VAL A 260 ALA A 258 VAL A 289 LEU A 250 PHE A 232	None	1.04A	3zosA-3nx3A: undetectable 3zosB-3nx3A: undetectable	3zosA-3nx3A: 23.08 3zosB-3nx3A: 23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3ohg	UNCHARACTERIZED PROTEIN FROM DUF2233 FAMILY (Bacteroides ovatus)	PF09992 (NAGPA)	5	VAL A 125 ALA A 118 LEU A 310 LEU A 277 PHE A  79	None	0.91A	3zosA-3ohgA: 1.8 3zosB-3ohgA: 1.8	3zosA-3ohgA: 21.97 3zosB-3ohgA: 21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3rj8	CARBOHYDRATE OXIDASE (Microdochium nivale)	PF01565 (FAD_binding_4) PF08031 (BBE)	5	VAL A 163 ALA A 175 GLY A 189 LEU A 183 GLY A 191	None	1.06A	3zosA-3rj8A: 1.1 3zosB-3rj8A: 1.0	3zosA-3rj8A: 20.68 3zosB-3rj8A: 20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3sti	PROTEASE DEGQ (Escherichia coli)	PF13365 (Trypsin_2)	5	ALA A 114 GLY A  65 ILE A 205 VAL A  77 LEU A 116	None	1.15A	3zosA-3stiA: undetectable 3zosB-3stiA: undetectable	3zosA-3stiA: 21.88 3zosB-3stiA: 21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3tl3	SHORT-CHAIN TYPE DEHYDROGENASE/REDUCT ASE (Mycobacterium ulcerans)	PF00106 (adh_short)	5	VAL A  32 ALA A  50 GLY A  18 ILE A  78 GLY A  13	None	1.13A	3zosA-3tl3A: undetectable 3zosB-3tl3A: undetectable	3zosA-3tl3A: 22.26 3zosB-3tl3A: 22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3tl3	SHORT-CHAIN TYPE DEHYDROGENASE/REDUCT ASE (Mycobacterium ulcerans)	PF00106 (adh_short)	5	VAL A  32 ALA A  50 GLY A  18 ILE A  78 VAL A  42	None	1.10A	3zosA-3tl3A: undetectable 3zosB-3tl3A: undetectable	3zosA-3tl3A: 22.26 3zosB-3tl3A: 22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3u1j	SERINE PROTEASE NS3 (Dengue virus)	PF00949 (Peptidase_S7)	5	LEU B  85 GLY B  39 ILE B 140 LEU B  76 GLY B 136	None	1.08A	3zosA-3u1jB: 1.7 3zosB-3u1jB: undetectable	3zosA-3u1jB: 19.50 3zosB-3u1jB: 19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3v48	PUTATIVE AMINOACRYLATE HYDROLASE RUTD (Escherichia coli)	PF00561 (Abhydrolase_1)	5	ALA A  98 LEU A 108 GLY A  90 ILE A 203 PHE A 190	None	1.04A	3zosA-3v48A: undetectable 3zosB-3v48A: undetectable	3zosA-3v48A: 24.50 3zosB-3v48A: 24.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3v75	OROTIDINE 5'-PHOSPHATE DECARBOXYLASE (Streptomyces avermitilis)	PF00215 (OMPdecase)	5	VAL A 244 GLY A 235 ILE A 273 LEU A 212 GLY A 238	None	1.11A	3zosA-3v75A: undetectable 3zosB-3v75A: undetectable	3zosA-3v75A: 24.49 3zosB-3v75A: 24.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3ve2	TRANSFERRIN-BINDING PROTEIN 2 (Neisseria meningitidis)	PF01298 (TbpB_B_D) PF17483 (TbpB_C) PF17484 (TbpB_A)	5	ALA A 282 LEU A 315 PHE A 164 LEU A 253 PHE A 319	None	0.98A	3zosA-3ve2A: 1.5 3zosB-3ve2A: 1.5	3zosA-3ve2A: 18.39 3zosB-3ve2A: 18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3vtf	UDP-GLUCOSE 6-DEHYDROGENASE (Pyrobaculum islandicum)	PF00984 (UDPG_MGDP_dh) PF03720 (UDPG_MGDP_dh_C) PF03721 (UDPG_MGDP_dh_N)	5	VAL A  14 ALA A  17 GLY A  43 ILE A  47 LEU A  65	None	1.08A	3zosA-3vtfA: undetectable 3zosB-3vtfA: undetectable	3zosA-3vtfA: 23.27 3zosB-3vtfA: 23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3wnv	GLYOXYLATE REDUCTASE (Paecilomyces sp. 'thermophila')	PF00389 (2-Hacid_dh) PF02826 (2-Hacid_dh_C)	5	VAL A 169 ALA A 116 GLY A 161 ILE A 180 GLY A 163	None	1.18A	3zosA-3wnvA: undetectable 3zosB-3wnvA: undetectable	3zosA-3wnvA: 25.00 3zosB-3wnvA: 25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3wrv	TM-1 PROTEIN (Solanum lycopersicum)	PF06792 (UPF0261)	5	ALA A 134 LEU A 103 GLY A  15 PHE A  66 GLY A 121	None	0.91A	3zosA-3wrvA: undetectable 3zosB-3wrvA: undetectable	3zosA-3wrvA: 22.48 3zosB-3wrvA: 22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3x27	CUCUMOPINE SYNTHASE (Marinactinospora thermotolerans)	no annotation	5	ALA A 248 LEU A 259 LEU A 288 ILE A 167 GLY A 215	None	1.05A	3zosA-3x27A: undetectable 3zosB-3x27A: undetectable	3zosA-3x27A: 23.18 3zosB-3x27A: 23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3zg4	ERFK/YBIS/YCFS/YNHG (Enterococcus faecium)	PF03734 (YkuD)	5	VAL A 407 ALA A 391 LEU A 393 GLY A 419 PHE A 454	None	0.86A	3zosA-3zg4A: undetectable 3zosB-3zg4A: undetectable	3zosA-3zg4A: 18.40 3zosB-3zg4A: 18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4bk1	PROBABLE SALICYLATE MONOOXYGENASE (Rhodococcus jostii)	PF01494 (FAD_binding_3)	5	VAL A 118 ALA A 121 LEU A 128 GLY A  13 GLY A  15	None None None FAD  A1398 (-3.4A) FAD  A1398 (-3.5A)	1.17A	3zosA-4bk1A: undetectable 3zosB-4bk1A: undetectable	3zosA-4bk1A: 20.88 3zosB-4bk1A: 20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4c0a	IQ MOTIF AND SEC7 DOMAIN-CONTAINING PROTEIN 1 (Homo sapiens)	PF01369 (Sec7) PF16453 (IQ_SEC7_PH)	5	ALA A 508 ILE A 538 VAL A 471 LEU A 468 GLY A 453	None	0.95A	3zosA-4c0aA: undetectable 3zosB-4c0aA: undetectable	3zosA-4c0aA: 20.72 3zosB-4c0aA: 20.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4ckr	EPITHELIAL DISCOIDIN DOMAIN-CONTAINING RECEPTOR 1 (Homo sapiens)	PF07714 (Pkinase_Tyr)	5	LEU A 805 LEU A 816 GLY A 818 ILE A 854 PHE A 861	None	0.36A	3zosA-4ckrA: 34.5 3zosB-4ckrA: 43.7	3zosA-4ckrA: 100.00 3zosB-4ckrA: 100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4crn	ERF1 IN RIBOSOME-BOUND ERF1-ERF3-GDPNP COMPLEX ERF3 IN RIBOSOME BOUND ERF1-ERF3-GDPNP COMPLEX (Saccharomyces cerevisiae)	PF00009 (GTP_EFTU) PF03143 (GTP_EFTU_D3) PF03144 (GTP_EFTU_D2) PF03463 (eRF1_1) PF03464 (eRF1_2) PF03465 (eRF1_3)	5	ALA P 596 GLY X 402 PHE X 386 GLY X 301 PHE X 300	None	1.04A	3zosA-4crnP: undetectable 3zosB-4crnP: undetectable	3zosA-4crnP: 22.57 3zosB-4crnP: 22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4gew	5'-TYROSYL-DNA PHOSPHODIESTERASE (Caenorhabditis elegans)	PF03372 (Exo_endo_phos) PF14555 (UBA_4)	5	ALA A 362 LEU A 115 GLY A 263 ILE A 221 GLY A 328	GOL  A 408 ( 4.2A) GOL  A 408 (-3.9A) None None GOL  A 403 (-4.0A)	1.06A	3zosA-4gewA: undetectable 3zosB-4gewA: undetectable	3zosA-4gewA: 21.39 3zosB-4gewA: 21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4h1s	5'-NUCLEOTIDASE (Homo sapiens)	PF00149 (Metallophos) PF02872 (5_nucleotid_C)	5	ALA A 135 GLY A  84 ILE A 173 VAL A 101 LEU A 131	None	0.96A	3zosA-4h1sA: undetectable 3zosB-4h1sA: undetectable	3zosA-4h1sA: 22.90 3zosB-4h1sA: 22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4hes	BETA-LACTAMASE CLASS A-LIKE PROTEIN (Veillonella parvula)	PF13354 (Beta-lactamase2)	5	ALA A  44 LEU A  14 GLY A 260 ILE A  27 VAL A 267	None	1.06A	3zosA-4hesA: undetectable 3zosB-4hesA: undetectable	3zosA-4hesA: 22.29 3zosB-4hesA: 22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4i3g	BETA-GLUCOSIDASE (Streptomyces venezuelae)	PF00933 (Glyco_hydro_3) PF01915 (Glyco_hydro_3_C) PF14310 (Fn3-like)	5	LEU A 627 GLY A 652 PHE A 705 VAL A 648 GLY A 372	None	1.11A	3zosA-4i3gA: undetectable 3zosB-4i3gA: undetectable	3zosA-4i3gA: 17.33 3zosB-4i3gA: 17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4i3g	BETA-GLUCOSIDASE (Streptomyces venezuelae)	PF00933 (Glyco_hydro_3) PF01915 (Glyco_hydro_3_C) PF14310 (Fn3-like)	5	LEU A 627 LEU A 654 GLY A 652 VAL A 648 GLY A 372	None	1.04A	3zosA-4i3gA: undetectable 3zosB-4i3gA: undetectable	3zosA-4i3gA: 17.33 3zosB-4i3gA: 17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4jz7	CARBAMATE KINASE (Giardia intestinalis)	PF00696 (AA_kinase)	5	VAL A  32 ALA A  35 GLY A  54 LEU A 298 GLY A  13	None None ANP  A1001 ( 4.6A) None ANP  A1001 (-3.3A)	1.14A	3zosA-4jz7A: undetectable 3zosB-4jz7A: undetectable	3zosA-4jz7A: 20.27 3zosB-4jz7A: 20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4lis	UDP-GLUCOSE 4-EPIMERASE (Aspergillus nidulans)	PF16363 (GDP_Man_Dehyd)	5	VAL A  30 ALA A  55 GLY A  16 PHE A 125 LEU A  44	None	1.00A	3zosA-4lisA: undetectable 3zosB-4lisA: undetectable	3zosA-4lisA: 23.02 3zosB-4lisA: 23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4lsw	D-2-HYDROXYACID DEHYDROGENSASE PROTEIN (Ketogulonicigenium vulgare)	PF00389 (2-Hacid_dh) PF02826 (2-Hacid_dh_C)	5	ALA A 148 LEU A 205 VAL A 109 LEU A 164 GLY A 157	None	1.15A	3zosA-4lswA: undetectable 3zosB-4lswA: undetectable	3zosA-4lswA: 24.07 3zosB-4lswA: 24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4npc	SORBITOL DEHYDROGENASE (Brucella suis)	PF13561 (adh_short_C2)	5	VAL A  43 ALA A  64 GLY A  29 ILE A  93 GLY A  24	None	1.13A	3zosA-4npcA: undetectable 3zosB-4npcA: undetectable	3zosA-4npcA: 21.34 3zosB-4npcA: 21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4p5b	THYMIDYLATE SYNTHASE THYX (Streptomyces cacaoi)	PF02511 (Thy1)	5	ALA A 165 LEU A 169 GLY A 103 ILE A  78 LEU A 156	None None SO4  A 303 ( 3.8A) None None	1.04A	3zosA-4p5bA: undetectable 3zosB-4p5bA: undetectable	3zosA-4p5bA: 22.19 3zosB-4p5bA: 22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4trt	DNA POLYMERASE III SUBUNIT BETA (Deinococcus radiodurans)	PF00712 (DNA_pol3_beta) PF02767 (DNA_pol3_beta_2) PF02768 (DNA_pol3_beta_3)	5	LEU A  15 ILE A  22 VAL A   6 LEU A  89 PHE A  68	None	0.98A	3zosA-4trtA: undetectable 3zosB-4trtA: undetectable	3zosA-4trtA: 22.64 3zosB-4trtA: 22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4xmm	NUCLEOPORIN SEH1 (Saccharomyces cerevisiae)	PF00400 (WD40)	5	ALA C 126 GLY C 132 VAL C 185 LEU C 171 GLY C 129	None	1.01A	3zosA-4xmmC: undetectable 3zosB-4xmmC: undetectable	3zosA-4xmmC: 20.44 3zosB-4xmmC: 20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4xpr	ALPHA-GLUCOSIDASE (Pseudopedobacter saltans)	PF01055 (Glyco_hydro_31) PF17137 (DUF5110)	5	VAL A  42 ALA A  40 LEU A  80 LEU A 193 VAL A 203	None	1.16A	3zosA-4xprA: undetectable 3zosB-4xprA: undetectable	3zosA-4xprA: 18.71 3zosB-4xprA: 18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4xqe	HOMOSPERMIDINE SYNTHASE (Blastochloris viridis)	PF03435 (Sacchrp_dh_NADP) PF16653 (Sacchrp_dh_C)	5	ALA A 109 LEU A  98 ILE A 419 VAL A  15 LEU A  79	None	1.12A	3zosA-4xqeA: undetectable 3zosB-4xqeA: undetectable	3zosA-4xqeA: 22.65 3zosB-4xqeA: 22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5bp7	SAM-DEPENDENT METHYLTRANSFERASE (Geobacter sulfurreducens)	PF13847 (Methyltransf_31)	5	VAL A 111 ALA A 109 GLY A  49 ILE A  21 GLY A  47	SAH  A 301 (-4.1A) None None None SAH  A 301 (-3.5A)	1.08A	3zosA-5bp7A: 0.9 3zosB-5bp7A: undetectable	3zosA-5bp7A: 22.29 3zosB-5bp7A: 22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5doi	TELOMERASE ASSOCIATED PROTEIN P45 (Tetrahymena thermophila)	no annotation	5	ALA E  59 LEU E  61 GLY E  81 ILE E  73 LEU E  10	None	1.05A	3zosA-5doiE: undetectable 3zosB-5doiE: undetectable	3zosA-5doiE: 18.03 3zosB-5doiE: 18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5dp2	CURF (Lyngbya majuscula)	PF08240 (ADH_N) PF13602 (ADH_zinc_N_2)	5	VAL A 171 GLY A 330 VAL A 192 LEU A 193 GLY A 164	None None None None NAP  A 401 (-3.2A)	1.17A	3zosA-5dp2A: undetectable 3zosB-5dp2A: undetectable	3zosA-5dp2A: 21.98 3zosB-5dp2A: 21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5egn	ESTERASE (uncultured bacterium)	PF12697 (Abhydrolase_6)	5	VAL A  75 ALA A  72 GLY A  91 ILE A  49 PHE A  42	None	1.06A	3zosA-5egnA: undetectable 3zosB-5egnA: undetectable	3zosA-5egnA: 22.51 3zosB-5egnA: 22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5gkx	UNCHARACTERIZED PROTEIN (Thermococcus onnurineus)	PF14336 (DUF4392)	5	ALA A 205 GLY A  65 ILE A 153 VAL A 257 LEU A 216	None	0.83A	3zosA-5gkxA: undetectable 3zosB-5gkxA: undetectable	3zosA-5gkxA: 20.43 3zosB-5gkxA: 20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5jen	LYSOZYME C (Gallus gallus)	PF00062 (Lys)	5	VAL B  29 ALA B  32 LEU B   8 ILE B 124 LEU B  56	None	1.10A	3zosA-5jenB: undetectable 3zosB-5jenB: undetectable	3zosA-5jenB: 18.30 3zosB-5jenB: 18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5mms	CYSTATHIONINE BETA-SYNTHASE (Homo sapiens)	PF00291 (PALP)	5	ALA A 155 ILE A 122 VAL A 180 LEU A 181 GLY A 148	None	1.05A	3zosA-5mmsA: undetectable 3zosB-5mmsA: undetectable	3zosA-5mmsA: 21.99 3zosB-5mmsA: 21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5oom	39S RIBOSOMAL PROTEIN L22, MITOCHONDRIAL (Homo sapiens)	PF00237 (Ribosomal_L22)	5	VAL T 120 ALA T 124 LEU T  90 ILE T 116 LEU T 178	None	1.13A	3zosA-5oomT: undetectable 3zosB-5oomT: undetectable	3zosA-5oomT: 19.94 3zosB-5oomT: 19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5sv4	SINGLE DOMAIN ANTIBODY A3C8 (Lama glama)	PF07686 (V-set)	5	VAL A   2 ALA A  24 LEU A   4 VAL A  79 LEU A  29	None	0.96A	3zosA-5sv4A: undetectable 3zosB-5sv4A: undetectable	3zosA-5sv4A: 16.24 3zosB-5sv4A: 16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5tpr	3-DEHYDROQUINATE SYNTHASE (Trichormus variabilis)	PF01761 (DHQ_synthase)	5	VAL A  55 ALA A  53 LEU A  62 LEU A  78 GLY A  64	None None NAD  A 503 (-4.7A) None None	0.89A	3zosA-5tprA: undetectable 3zosB-5tprA: undetectable	3zosA-5tprA: 20.62 3zosB-5tprA: 20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5ysb	LIN1841 PROTEIN (Listeria innocua)	no annotation	5	ALA A 166 LEU A 158 LEU A 178 GLY A 189 LEU A 151	None	0.96A	3zosA-5ysbA: undetectable 3zosB-5ysbA: undetectable	3zosA-5ysbA: 17.76 3zosB-5ysbA: 17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6ei3	PROTON-DEPENDENT OLIGOPEPTIDE TRANSPORTER FAMILY PROTEIN (Xanthomonas campestris)	no annotation	5	VAL A 225 ALA A 228 LEU A 275 GLY A 277 GLY A 280	None None 78M  A 614 ( 4.7A) None 78M  A 614 ( 4.1A)	1.07A	3zosA-6ei3A: undetectable 3zosB-6ei3A: undetectable	3zosA-6ei3A: 20.97 3zosB-6ei3A: 20.97