SIMILAR PATTERNS OF AMINO ACIDS FOR 3ZOS_A_0LIA1000_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f82 BOTULINUM NEUROTOXIN
TYPE B

(Clostridium
botulinum) 		PF01742
(Peptidase_M27) 		5 MET A  91
ILE A  38
ILE A  44
TYR A  33
ILE A  42
 None
 1.10A 3zosA-1f82A:
undetectable		 3zosA-1f82A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fok PROTEIN (FOKI
RESTRICTION
ENDONUCLEASE)

(Planomicrobium
okeanokoites) 		PF02980
(FokI_C)
PF02981
(FokI_N)
PF09254
(Endonuc-FokI_C)
PF16902
(Type2_restr_D3) 		5 ILE A 313
LEU A 317
ILE A 358
ILE A 356
ILE A 352
 None
 1.02A 3zosA-1fokA:
undetectable		 3zosA-1fokA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fot CAMP-DEPENDENT
PROTEIN KINASE TYPE
1

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		5 ILE A 147
ILE A 148
MET A 162
TYR A 166
ILE A 226
 None
 0.63A 3zosA-1fotA:
21.3		 3zosA-1fotA:
25.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g5u PROFILIN

(Hevea
brasiliensis) 		PF00235
(Profilin) 		5 ILE A1083
ILE A1103
ILE A1102
TYR A1125
ILE A1026
 None
 0.97A 3zosA-1g5uA:
undetectable		 3zosA-1g5uA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gng GLYCOGEN SYNTHASE
KINASE-3 BETA

(Homo sapiens) 		PF00069
(Pkinase) 		5 ILE A 100
MET A 101
LEU A 104
ILE A 109
TYR A 134
 None
 0.62A 3zosA-1gngA:
20.2		 3zosA-1gngA:
23.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1luf MUSCLE-SPECIFIC
TYROSINE KINASE
RECEPTOR MUSK

(Rattus
norvegicus) 		PF07714
(Pkinase_Tyr) 		5 MET A 629
ILE A 637
TYR A 656
MET A 657
ILE A 740
 None
 0.69A 3zosA-1lufA:
28.5		 3zosA-1lufA:
39.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mc3 GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E

(Escherichia
coli) 		PF00483
(NTP_transferase) 		5 LEU A 104
ILE A   4
ILE A   5
TYR A  35
ILE A  52
 None
 1.03A 3zosA-1mc3A:
undetectable		 3zosA-1mc3A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mdf 2,3-DIHYDROXYBENZOAT
E-AMP LIGASE

(Bacillus
subtilis) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		5 ILE A  85
LEU A  82
ILE A 127
ILE A 128
ILE A 155
 None
 1.05A 3zosA-1mdfA:
undetectable		 3zosA-1mdfA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mp3 GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E

(Salmonella
enterica) 		PF00483
(NTP_transferase) 		5 LEU A 107
ILE A   7
ILE A   8
TYR A  38
ILE A  55
 None
 0.94A 3zosA-1mp3A:
undetectable		 3zosA-1mp3A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qzm ATP-DEPENDENT
PROTEASE LA

(Escherichia
coli) 		no annotation 5 ILE A 501
ILE A 532
ILE A 531
TYR A 578
ILE A 529
 None
 1.08A 3zosA-1qzmA:
undetectable		 3zosA-1qzmA:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1saw HYPOTHETICAL PROTEIN
FLJ36880

(Homo sapiens) 		PF01557
(FAA_hydrolase) 		5 MET A 165
ILE A 172
ILE A 169
MET A  91
ILE A 188
 None
 1.14A 3zosA-1sawA:
undetectable		 3zosA-1sawA:
20.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ILE X  57
MET X  58
TYR X  84
MET X  85
ILE X 146
 None
None
STU  X 902 (-4.6A)
None
None
 0.65A 3zosA-2dq7X:
29.9		 3zosA-2dq7X:
35.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gy7 ANGIOPOIETIN-2

(Homo sapiens) 		PF00147
(Fibrinogen_C) 		5 ILE A 309
LEU A 355
ILE A 325
ILE A 324
ILE A 491
 None
 1.07A 3zosA-2gy7A:
undetectable		 3zosA-2gy7A:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hak SERINE/THREONINE-PRO
TEIN KINASE MARK1

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		5 ILE A 103
LEU A 107
ILE A 112
TYR A 131
ILE A 191
 None
 0.66A 3zosA-2hakA:
20.3		 3zosA-2hakA:
26.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i6l MITOGEN-ACTIVATED
PROTEIN KINASE 6

(Homo sapiens) 		PF00069
(Pkinase) 		6 ILE A  68
LEU A  72
ILE A  77
TYR A 110
MET A 111
ILE A 169
 None
 0.81A 3zosA-2i6lA:
21.8		 3zosA-2i6lA:
27.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2inr DNA TOPOISOMERASE 4
SUBUNIT A

(Staphylococcus
aureus) 		PF00521
(DNA_topoisoIV) 		5 ILE A 209
MET A 206
ILE A 483
ILE A 223
ILE A 220
 None
 1.13A 3zosA-2inrA:
undetectable		 3zosA-2inrA:
21.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ogv MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
PRECURSOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ILE A 636
MET A 637
ILE A 646
TYR A 665
ILE A 794
 None
 0.93A 3zosA-2ogvA:
32.5		 3zosA-2ogvA:
35.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2p4i ANGIOPOIETIN-1
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 879
ILE A 885
ILE A 886
TYR A 904
ILE A 980
 MR9  A 301 (-4.1A)
MR9  A 301 ( 4.5A)
MR9  A 301 (-4.0A)
MR9  A 301 (-3.8A)
MR9  A 301 (-4.6A)
 0.72A 3zosA-2p4iA:
13.6		 3zosA-2p4iA:
33.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pk3 GDP-6-DEOXY-D-LYXO-4
-HEXULOSE REDUCTASE

(Aneurinibacillus
thermoaerophilus) 		PF16363
(GDP_Man_Dehyd) 		5 ILE A 112
LEU A 110
ILE A 163
ILE A 162
TYR A 158
 A2R  A 401 (-4.2A)
None
None
None
None
 1.09A 3zosA-2pk3A:
undetectable		 3zosA-2pk3A:
23.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 MET A 538
ILE A 547
ILE A 548
TYR A 566
ILE A 642
 None
 0.83A 3zosA-2psqA:
23.7		 3zosA-2psqA:
33.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qob EPHRIN RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ILE A 673
MET A 674
ILE A 682
ILE A 683
MET A 702
 None
None
None
None
PTR  A 701 ( 3.5A)
 0.77A 3zosA-2qobA:
24.3		 3zosA-2qobA:
34.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2r2p EPHRIN TYPE-A
RECEPTOR 5

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		6 ILE A 727
MET A 728
ILE A 736
ILE A 737
TYR A 755
MET A 756
 None
 0.65A 3zosA-2r2pA:
30.6		 3zosA-2r2pA:
35.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vxo GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG]

(Homo sapiens) 		PF00117
(GATase)
PF00958
(GMP_synt_C)
PF02540
(NAD_synthase) 		5 ILE A  54
ILE A  73
ILE A  74
MET A 110
ILE A 103
 None
 1.10A 3zosA-2vxoA:
undetectable		 3zosA-2vxoA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xk9 CHECKPOINT KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		5 ILE A 276
ILE A 285
ILE A 286
MET A 304
ILE A 366
 None
 0.56A 3zosA-2xk9A:
19.1		 3zosA-2xk9A:
26.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xk9 CHECKPOINT KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		5 ILE A 276
LEU A 280
ILE A 285
ILE A 286
ILE A 366
 None
 0.70A 3zosA-2xk9A:
19.1		 3zosA-2xk9A:
26.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2xyu EPHRIN TYPE-A
RECEPTOR 4,

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		5 ILE A 673
ILE A 682
ILE A 683
TYR A 701
MET A 702
 None
None
Q9G  A1898 ( 4.9A)
Q9G  A1898 (-4.8A)
None
 0.42A 3zosA-2xyuA:
24.2		 3zosA-2xyuA:
35.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2xyu EPHRIN TYPE-A
RECEPTOR 4,

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		5 ILE A 673
MET A 674
ILE A 683
TYR A 701
MET A 702
 None
Q9G  A1898 (-3.9A)
Q9G  A1898 ( 4.9A)
Q9G  A1898 (-4.8A)
None
 0.77A 3zosA-2xyuA:
24.2		 3zosA-2xyuA:
35.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y4o PHENYLACETATE-COENZY
ME A LIGASE

(Burkholderia
cenocepacia) 		PF00501
(AMP-binding)
PF14535
(AMP-binding_C_2) 		5 ILE A 151
LEU A 136
ILE A 184
ILE A 185
ILE A 213
 None
 0.88A 3zosA-2y4oA:
undetectable		 3zosA-2y4oA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b2n UNCHARACTERIZED
PROTEIN Q99UF4

(Staphylococcus
aureus) 		PF00072
(Response_reg) 		5 ILE A  78
ILE A  81
ILE A  82
TYR A  91
ILE A  54
 None
 1.09A 3zosA-3b2nA:
undetectable		 3zosA-3b2nA:
16.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 MET A 538
ILE A 547
ILE A 548
TYR A 566
ILE A 642
 None
None
None
M33  A1996 ( 4.7A)
None
 0.66A 3zosA-3b2tA:
23.4		 3zosA-3b2tA:
34.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE

(Trypanosoma
brucei) 		PF01048
(PNP_UDP_1) 		5 ILE A 290
ILE A  38
ILE A  39
TYR A  53
ILE A  83
 None
 1.02A 3zosA-3bjeA:
undetectable		 3zosA-3bjeA:
21.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 MET A 535
ILE A 544
ILE A 545
TYR A 563
ILE A 639
 C4F  A   1 ( 3.7A)
None
C4F  A   1 ( 4.0A)
None
None
 0.81A 3zosA-3c4fA:
24.5		 3zosA-3c4fA:
37.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e3b CASEIN KINASE II
SUBUNIT ALPHA'

(Homo sapiens) 		PF00069
(Pkinase) 		5 ILE X  85
LEU X  89
ILE X  95
ILE X  96
TYR X 116
 None
None
None
CCK  X 351 ( 4.6A)
CCK  X 351 (-4.3A)
 0.70A 3zosA-3e3bX:
12.1		 3zosA-3e3bX:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eb0 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		6 ILE A  53
MET A  54
LEU A  57
ILE A  62
ILE A  63
TYR A 119
 None
None
None
None
DRK  A 384 ( 4.5A)
DRK  A 384 (-4.4A)
 0.56A 3zosA-3eb0A:
21.1		 3zosA-3eb0A:
24.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fe3 MAP/MICROTUBULE
AFFINITY-REGULATING
KINASE 3

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		5 ILE A 106
LEU A 110
ILE A 115
TYR A 134
ILE A 194
 None
 0.88A 3zosA-3fe3A:
22.3		 3zosA-3fe3A:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h4j SNF1-LIKE PROTEIN
KINASE SSP2

(Schizosaccharomyces
pombe) 		no annotation 5 ILE B  94
ILE B  95
MET B 109
TYR B 113
ILE B 172
 None
 0.70A 3zosA-3h4jB:
9.1		 3zosA-3h4jB:
25.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		5 ILE A 103
LEU A 107
ILE A 112
TYR A 131
ILE A 191
 None
 0.81A 3zosA-3iecA:
22.0		 3zosA-3iecA:
26.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		5 ILE A 103
MET A 104
ILE A 112
TYR A 131
ILE A 191
 None
 0.97A 3zosA-3iecA:
22.0		 3zosA-3iecA:
26.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kul EPHRIN TYPE-A
RECEPTOR 8

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		6 ILE A 687
MET A 688
ILE A 696
ILE A 697
TYR A 715
MET A 716
 None
None
None
None
GOL  A 403 (-4.1A)
None
 0.83A 3zosA-3kulA:
24.4		 3zosA-3kulA:
37.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ll3 GLUCONATE KINASE

(Lactobacillus
acidophilus) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		5 ILE A  65
LEU A  18
ILE A   5
ILE A   4
ILE A  72
 None
 1.00A 3zosA-3ll3A:
undetectable		 3zosA-3ll3A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m1m ORF904

(Sulfolobus
islandicus) 		PF09250
(Prim-Pol)
PF13010
(pRN1_helical) 		5 ILE A 331
LEU A 334
ILE A 296
ILE A 295
ILE A 292
 None
 1.08A 3zosA-3m1mA:
undetectable		 3zosA-3m1mA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3me8 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Aquifex
aeolicus) 		PF02630
(SCO1-SenC) 		5 ILE A 113
LEU A 133
ILE A  31
ILE A  32
ILE A  68
 None
 1.04A 3zosA-3me8A:
undetectable		 3zosA-3me8A:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mn3 CARBON
CATABOLITE-DEREPRESS
ING PROTEIN KINASE

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		5 ILE A 115
ILE A 116
MET A 130
TYR A 134
ILE A 193
 None
 0.65A 3zosA-3mn3A:
20.3		 3zosA-3mn3A:
29.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mn3 CARBON
CATABOLITE-DEREPRESS
ING PROTEIN KINASE

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		5 LEU A 110
ILE A 115
ILE A 116
TYR A 134
ILE A 193
 None
 0.52A 3zosA-3mn3A:
20.3		 3zosA-3mn3A:
29.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3op1 MACROLIDE-EFFLUX
PROTEIN

(Streptococcus
pneumoniae) 		PF01687
(Flavokinase)
PF06574
(FAD_syn) 		5 ILE A  51
ILE A 122
ILE A 123
TYR A 144
ILE A 150
 None
 0.94A 3zosA-3op1A:
undetectable		 3zosA-3op1A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pm9 PUTATIVE
OXIDOREDUCTASE

(Rhodopseudomonas
palustris) 		PF01565
(FAD_binding_4)
PF02913
(FAD-oxidase_C) 		5 ILE A 468
MET A 469
LEU A  77
ILE A  99
ILE A 215
 None
None
None
None
FAD  A 476 (-4.6A)
 1.07A 3zosA-3pm9A:
undetectable		 3zosA-3pm9A:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rgg PHOSPHORIBOSYLAMINOI
MIDAZOLE
CARBOXYLASE, PURE
PROTEIN

(Treponema
denticola) 		PF00731
(AIRC) 		5 ILE A  30
ILE A   7
ILE A   6
MET A  49
ILE A  34
 None
 1.13A 3zosA-3rggA:
undetectable		 3zosA-3rggA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3te6 REGULATORY PROTEIN
SIR3

(Saccharomyces
cerevisiae) 		no annotation 5 LEU A 574
ILE A 693
ILE A 694
MET A 593
ILE A 665
 None
 0.88A 3zosA-3te6A:
undetectable		 3zosA-3te6A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uho GLUTAMATE RACEMASE

(Campylobacter
jejuni) 		PF01177
(Asp_Glu_race) 		5 ILE A  68
LEU A  66
ILE A  63
ILE A   3
ILE A  29
 None
 0.98A 3zosA-3uhoA:
undetectable		 3zosA-3uhoA:
21.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3v5q NT-3 GROWTH FACTOR
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ILE A 600
MET A 615
TYR A 619
MET A 620
ILE A 695
 0F4  A 902 (-4.1A)
None
0F4  A 902 (-4.2A)
None
0F4  A 902 (-4.6A)
 0.58A 3zosA-3v5qA:
32.9		 3zosA-3v5qA:
45.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vo2 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Zea mays) 		PF00175
(NAD_binding_1) 		5 ILE A 166
LEU A 168
ILE A 281
MET A 297
ILE A 284
 None
 1.15A 3zosA-3vo2A:
undetectable		 3zosA-3vo2A:
20.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zfx EPHRIN TYPE-B
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ILE A 671
MET A 672
ILE A 680
ILE A 681
MET A 700
 None
 0.66A 3zosA-3zfxA:
30.5		 3zosA-3zfxA:
37.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4af3 AURORA KINASE B

(Homo sapiens) 		PF00069
(Pkinase) 		5 ILE A 128
LEU A 132
ILE A 137
TYR A 156
ILE A 216
 None
None
None
VX6  A 500 (-4.2A)
None
 1.01A 3zosA-4af3A:
19.5		 3zosA-4af3A:
26.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4asy GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E

(Pseudomonas
aeruginosa) 		PF00483
(NTP_transferase) 		5 LEU A 106
ILE A   6
ILE A   7
TYR A  37
ILE A  54
 None
 0.96A 3zosA-4asyA:
undetectable		 3zosA-4asyA:
22.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4at3 BDNF/NT-3 GROWTH
FACTORS RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ILE A 616
MET A 631
TYR A 635
MET A 636
ILE A 708
 None
None
LTI  A1839 (-4.7A)
None
None
 0.65A 3zosA-4at3A:
31.8		 3zosA-4at3A:
47.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4aw5 EPHRIN TYPE-B
RECEPTOR 4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ILE A 143
MET A 144
ILE A 152
ILE A 153
MET A 172
 None
 0.66A 3zosA-4aw5A:
24.6		 3zosA-4aw5A:
37.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b99 MITOGEN-ACTIVATED
PROTEIN KINASE 7

(Homo sapiens) 		PF00069
(Pkinase) 		5 ILE A 105
ILE A 114
ILE A 115
MET A 140
ILE A 198
 None
None
R4L  A1394 (-4.9A)
None
None
 0.92A 3zosA-4b99A:
6.7		 3zosA-4b99A:
26.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ckr EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 ILE A 675
MET A 676
LEU A 679
ILE A 684
ILE A 685
MET A 699
TYR A 703
MET A 704
ILE A 782
 None
DI1  A1000 (-3.6A)
DI1  A1000 (-4.5A)
DI1  A1000 ( 4.5A)
DI1  A1000 (-4.5A)
DI1  A1000 ( 4.1A)
DI1  A1000 (-4.0A)
None
DI1  A1000 (-4.5A)
 0.46A 3zosA-4ckrA:
34.5		 3zosA-4ckrA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f0g SERINE/THREONINE-PRO
TEIN KINASE ROCO4

(Dictyostelium
discoideum) 		PF07714
(Pkinase_Tyr) 		5 ILE A1081
MET A1082
LEU A1085
ILE A1090
MET A1103
 None
 0.77A 3zosA-4f0gA:
25.5		 3zosA-4f0gA:
29.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4f0i HIGH AFFINITY NERVE
GROWTH FACTOR
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ILE A 571
MET A 586
TYR A 590
MET A 591
ILE A 665
 None
 0.56A 3zosA-4f0iA:
33.5		 3zosA-4f0iA:
44.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fr4 SERINE/THREONINE-PRO
TEIN KINASE 32A

(Homo sapiens) 		PF00069
(Pkinase) 		5 ILE A  74
MET A  75
LEU A  78
MET A  98
ILE A 162
 None
 1.08A 3zosA-4fr4A:
20.7		 3zosA-4fr4A:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ho4 GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E

(Aneurinibacillus
thermoaerophilus) 		PF00483
(NTP_transferase) 		5 LEU A 104
ILE A   4
ILE A   5
TYR A  35
ILE A  52
 None
 0.95A 3zosA-4ho4A:
undetectable		 3zosA-4ho4A:
26.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hvi TYROSINE-PROTEIN
KINASE JAK3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ILE A 874
LEU A 878
ILE A 883
TYR A 904
ILE A 965
 None
None
None
19S  A1201 (-4.7A)
None
 0.62A 3zosA-4hviA:
22.8		 3zosA-4hviA:
33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4k33 FIBROBLAST GROWTH
FACTOR RECEPTOR 3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 MET A 529
ILE A 538
ILE A 539
TYR A 557
ILE A 633
 None
 0.70A 3zosA-4k33A:
30.4		 3zosA-4k33A:
34.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mvf CALCIUM-DEPENDENT
PROTEIN KINASE 2

(Plasmodium
falciparum) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		5 ILE A 120
MET A 121
LEU A 124
ILE A 129
ILE A 211
 None
 0.78A 3zosA-4mvfA:
19.1		 3zosA-4mvfA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ILE A 950
ILE A 959
ILE A 960
TYR A 980
ILE A1039
 None
None
None
2TT  A1202 (-4.6A)
None
 0.58A 3zosA-4oliA:
26.1		 3zosA-4oliA:
20.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p2k EPHRIN TYPE-A
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		5 ILE A 666
ILE A 675
ILE A 676
TYR A 694
MET A 695
 None
 0.74A 3zosA-4p2kA:
30.0		 3zosA-4p2kA:
36.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p2k EPHRIN TYPE-A
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		5 MET A 667
ILE A 675
ILE A 676
TYR A 694
MET A 695
 None
 0.92A 3zosA-4p2kA:
30.0		 3zosA-4p2kA:
36.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q7l UNCHARACTERIZED ABC
TRANSPORTER
ATP-BINDING PROTEIN
TM_0288

(Thermotoga
maritima) 		PF00005
(ABC_tran) 		5 ILE A 560
LEU A 386
ILE A 545
MET A 534
ILE A 514
 None
 1.05A 3zosA-4q7lA:
undetectable		 3zosA-4q7lA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4red 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1

(Homo sapiens) 		PF00069
(Pkinase) 		5 ILE A  78
ILE A  79
MET A  93
TYR A  97
ILE A 157
 None
 0.65A 3zosA-4redA:
13.8		 3zosA-4redA:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rew 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1

(Homo sapiens) 		PF00069
(Pkinase)
PF16579
(AdenylateSensor) 		5 ILE A  78
ILE A  79
MET A  93
TYR A  97
ILE A 157
 None
STU  A 601 ( 4.6A)
None
STU  A 601 (-4.4A)
None
 0.69A 3zosA-4rewA:
22.1		 3zosA-4rewA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xrl MITOGEN-ACTIVATED
PROTEIN KINASE 1

(Rattus
norvegicus) 		PF00069
(Pkinase) 		5 ILE A  72
ILE A  81
ILE A  82
MET A 106
ILE A 163
 None
 0.91A 3zosA-4xrlA:
20.9		 3zosA-4xrlA:
26.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zev PFHAD1

(Plasmodium
falciparum) 		PF08282
(Hydrolase_3) 		5 LEU A 234
ILE A  24
ILE A  23
TYR A 225
ILE A  55
 None
 1.15A 3zosA-4zevA:
undetectable		 3zosA-4zevA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zkt BONTOXILYSIN A

(Clostridium
botulinum) 		PF01742
(Peptidase_M27)
PF07951
(Toxin_R_bind_C)
PF07952
(Toxin_trans)
PF07953
(Toxin_R_bind_N) 		5 ILE A  90
ILE A  35
ILE A  41
TYR A  30
ILE A  39
 None
 1.01A 3zosA-4zktA:
undetectable		 3zosA-4zktA:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5awm STRESS-ACTIVATED
PROTEIN KINASE JNK

(Drosophila
melanogaster) 		PF00069
(Pkinase) 		5 MET A  75
ILE A  83
ILE A  84
MET A 109
ILE A 165
 None
 0.67A 3zosA-5awmA:
18.9		 3zosA-5awmA:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b48 2-OXOACID--FERREDOXI
N OXIDOREDUCTASE
ALPHA SUBUNIT

(Sulfurisphaera
tokodaii) 		PF01558
(POR)
PF01855
(POR_N) 		5 ILE A 509
LEU A 543
ILE A 520
ILE A 519
ILE A 566
 None
 1.07A 3zosA-5b48A:
undetectable		 3zosA-5b48A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5es1 MAP/MICROTUBULE
AFFINITY-REGULATING
KINASE 4

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		5 ILE A 106
LEU A 110
ILE A 115
TYR A 134
ILE A 194
 None
None
None
5RC  A4000 (-4.5A)
None
 0.82A 3zosA-5es1A:
22.4		 3zosA-5es1A:
25.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ILE A 950
ILE A 959
ILE A 960
TYR A 980
ILE A1039
 None
None
5U3  A1200 (-4.6A)
5U3  A1200 (-4.5A)
None
 0.45A 3zosA-5f1zA:
27.0		 3zosA-5f1zA:
34.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ILE A 950
LEU A 954
ILE A 959
TYR A 980
ILE A1039
 None
None
None
5U3  A1200 (-4.5A)
None
 0.74A 3zosA-5f1zA:
27.0		 3zosA-5f1zA:
34.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f64 POSITIVE
TRANSCRIPTION
REGULATOR EVGA

(Shigella
flexneri) 		PF00072
(Response_reg)
PF00196
(GerE) 		5 ILE A  13
ILE A   6
ILE A  50
MET A 106
ILE A   4
 None
 1.14A 3zosA-5f64A:
undetectable		 3zosA-5f64A:
19.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ILE A 647
MET A 648
ILE A 657
TYR A 676
ILE A 834
 748  A1001 ( 4.0A)
748  A1001 (-3.4A)
748  A1001 ( 4.4A)
748  A1001 (-4.0A)
748  A1001 (-4.8A)
 0.85A 3zosA-5grnA:
28.0		 3zosA-5grnA:
30.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hab RIBONUCLEASE J

(Methanolobus
psychrophilus) 		PF07521
(RMMBL)
PF12706
(Lactamase_B_2) 		5 ILE A 103
ILE A  31
ILE A  30
MET A  68
ILE A  22
 None
 1.09A 3zosA-5habA:
undetectable		 3zosA-5habA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5idt GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E

(Burkholderia
vietnamiensis) 		PF00483
(NTP_transferase) 		5 LEU A 107
ILE A   7
ILE A   8
TYR A  38
ILE A  55
 None
 0.92A 3zosA-5idtA:
undetectable		 3zosA-5idtA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ify GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E

(Burkholderia
vietnamiensis) 		PF00483
(NTP_transferase) 		5 LEU A 106
ILE A   6
ILE A   7
TYR A  37
ILE A  54
 None
 0.98A 3zosA-5ifyA:
undetectable		 3zosA-5ifyA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ig1 CAMK/CAMK2 PROTEIN
KINASE

(Salpingoeca
rosetta) 		PF00069
(Pkinase) 		5 ILE A  68
LEU A  72
ILE A  77
TYR A  96
ILE A 159
 None
None
None
PO4  A 401 (-4.8A)
None
 0.75A 3zosA-5ig1A:
23.0		 3zosA-5ig1A:
26.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iw7 RIBOSOME BIOGENESIS
PROTEIN
TSR1,RIBOSOME
BIOGENESIS PROTEIN
TSR1

(Saccharomyces
cerevisiae) 		PF04950
(RIBIOP_C)
PF08142
(AARP2CN) 		5 ILE A 100
ILE A 137
ILE A 138
MET A 142
ILE A  86
 None
 1.15A 3zosA-5iw7A:
undetectable		 3zosA-5iw7A:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jwb TYPE II
NADH:UBIQUINONE
OXIDOREDUCTASE

(Plasmodium
falciparum) 		PF07992
(Pyr_redox_2) 		5 ILE A  69
LEU A  46
ILE A 146
ILE A 145
ILE A 349
 None
FAD  A 601 ( 4.4A)
None
None
None
 1.01A 3zosA-5jwbA:
undetectable		 3zosA-5jwbA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k5z PARA

(Sulfolobus sp.
NOB8H2) 		PF13614
(AAA_31) 		5 ILE A 204
LEU A 161
ILE A 200
MET A 174
ILE A 237
 None
 1.04A 3zosA-5k5zA:
undetectable		 3zosA-5k5zA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5llb POLYPHOSPHATE KINASE
2

(Francisella
tularensis) 		no annotation 5 ILE C  85
ILE C  57
ILE C  56
MET C  74
ILE C 159
 None
 1.01A 3zosA-5llbC:
undetectable		 3zosA-5llbC:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mjk THIOREDOXIN
REDUCTASE

(Lactococcus
lactis) 		PF07992
(Pyr_redox_2) 		5 LEU A  34
ILE A  11
ILE A  10
TYR A  23
ILE A 107
 None
 1.10A 3zosA-5mjkA:
undetectable		 3zosA-5mjkA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mp2 TYPE II SECRETION
SYSTEM PROTEIN D

(Pseudomonas
aeruginosa) 		no annotation 5 ILE A 160
LEU A 173
ILE A 184
ILE A 183
ILE A 149
 None
 0.89A 3zosA-5mp2A:
undetectable		 3zosA-5mp2A:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nbr DEOXYRIBOSYLTRANSFER
ASE

(Leishmania
mexicana) 		PF05014
(Nuc_deoxyrib_tr) 		5 LEU A  97
ILE A  67
ILE A  66
TYR A  88
ILE A   7
 None
 1.14A 3zosA-5nbrA:
undetectable		 3zosA-5nbrA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nck N-ACETYLMANNOSAMINE
KINASE

(Fusobacterium
nucleatum) 		PF00480
(ROK) 		5 ILE A 132
LEU A 233
ILE A 231
ILE A 232
ILE A 128
 None
 1.01A 3zosA-5nckA:
undetectable		 3zosA-5nckA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u8s DNA REPLICATION
LICENSING FACTOR
MCM4

(Saccharomyces
cerevisiae) 		PF00493
(MCM)
PF14551
(MCM_N)
PF17207
(MCM_OB) 		5 ILE 4 829
LEU 4 704
ILE 4 564
MET 4 649
ILE 4 562
 None
 1.15A 3zosA-5u8s4:
2.1		 3zosA-5u8s4:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wnm RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 4

(Mus musculus) 		no annotation 5 MET A  73
ILE A  81
TYR A  98
MET A  99
ILE A 159
 None
None
VX6  A 402 (-4.3A)
None
None
 0.71A 3zosA-5wnmA:
25.6		 3zosA-5wnmA:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wzk PUMILIO HOMOLOG 23

(Arabidopsis
thaliana) 		no annotation 5 ILE A 381
MET A 382
LEU A 353
ILE A 366
ILE A 370
 None
 1.13A 3zosA-5wzkA:
2.1		 3zosA-5wzkA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b5e GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E

(Mycobacterium
tuberculosis) 		no annotation 5 LEU A 104
ILE A   4
ILE A   5
TYR A  35
ILE A  52
 None
 0.97A 3zosA-6b5eA:
undetectable		 3zosA-6b5eA:
12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bx6 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2

(Homo sapiens) 		no annotation 5 ILE A  76
ILE A  77
MET A  91
TYR A  95
ILE A 155
 None
EDJ  A 301 ( 4.7A)
None
EDJ  A 301 ( 4.8A)
None
 0.52A 3zosA-6bx6A:
18.8		 3zosA-6bx6A:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c9d SERINE/THREONINE-PRO
TEIN KINASE
MARK1,SERINE/THREONI
NE-PROTEIN KINASE
MARK1

(Homo sapiens) 		no annotation 5 ILE A 110
LEU A 114
ILE A 119
TYR A 138
ILE A 198
 None
 0.79A 3zosA-6c9dA:
21.2		 3zosA-6c9dA:
11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c9d SERINE/THREONINE-PRO
TEIN KINASE
MARK1,SERINE/THREONI
NE-PROTEIN KINASE
MARK1

(Homo sapiens) 		no annotation 5 ILE A 110
MET A 111
ILE A 119
TYR A 138
ILE A 198
 None
 0.97A 3zosA-6c9dA:
21.2		 3zosA-6c9dA:
11.78