SIMILAR PATTERNS OF AMINO ACIDS FOR 3ZOS_A_0LIA1000

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k9a CARBOXYL-TERMINAL
SRC KINASE

(Rattus
norvegicus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		8 ALA A 220
LYS A 222
GLU A 236
THR A 266
LEU A 305
HIS A 312
ARG A 313
LEU A 321
 None
 0.62A 3zosA-1k9aA:
28.2		 3zosA-1k9aA:
25.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1luf MUSCLE-SPECIFIC
TYROSINE KINASE
RECEPTOR MUSK

(Rattus
norvegicus) 		PF07714
(Pkinase_Tyr) 		7 ALA A 606
LYS A 608
LEU A 715
HIS A 722
LEU A 731
ALA A 741
ASP A 742
 None
 0.74A 3zosA-1lufA:
28.5		 3zosA-1lufA:
39.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		10 LEU A 267
ALA A 288
LYS A 290
GLU A 305
THR A 334
LEU A 373
HIS A 380
ARG A 381
LEU A 389
ALA A 399
 P16  A   2 ( 4.2A)
P16  A   2 (-3.4A)
P16  A   2 (-4.5A)
P16  A   2 (-4.2A)
P16  A   2 (-3.7A)
None
None
None
P16  A   2 (-4.4A)
P16  A   2 (-3.5A)
 0.90A 3zosA-1opkA:
29.5		 3zosA-1opkA:
26.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1py5 TGF-BETA RECEPTOR
TYPE I

(Homo sapiens) 		PF00069
(Pkinase)
PF08515
(TGF_beta_GS) 		8 ALA A 230
LYS A 232
GLU A 245
LEU A 316
HIS A 331
ARG A 332
LEU A 340
ALA A 350
 PY1  A 700 (-3.5A)
PY1  A 700 (-3.9A)
PY1  A 700 ( 4.9A)
None
None
None
PY1  A 700 (-4.4A)
PY1  A 700 ( 4.2A)
 0.78A 3zosA-1py5A:
24.1		 3zosA-1py5A:
25.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q8y SR PROTEIN KINASE

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		7 LEU A 164
ALA A 185
LYS A 187
GLU A 202
HIS A 292
LEU A 301
ALA A 549
 ADP  A 810 ( 4.3A)
ADP  A 810 (-3.3A)
ADP  A 810 (-3.1A)
None
None
ADP  A 810 (-4.7A)
None
 0.79A 3zosA-1q8yA:
20.1		 3zosA-1q8yA:
22.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1rjb FL CYTOKINE RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 616
ALA A 642
LYS A 644
GLU A 661
HIS A 809
ARG A 810
LEU A 818
ASP A 829
 None
 0.87A 3zosA-1rjbA:
32.8		 3zosA-1rjbA:
32.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1rjb FL CYTOKINE RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 616
ALA A 642
LYS A 644
GLU A 661
LEU A 802
HIS A 809
LEU A 818
ASP A 829
 None
 0.73A 3zosA-1rjbA:
32.8		 3zosA-1rjbA:
32.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		10 LEU A 595
ALA A 621
LYS A 623
GLU A 640
THR A 670
LEU A 783
HIS A 790
LEU A 799
ASP A 810
PHE A 811
 STI  A   3 ( 3.8A)
STI  A   3 (-3.5A)
STI  A   3 (-3.7A)
STI  A   3 (-3.6A)
STI  A   3 (-3.2A)
None
STI  A   3 (-4.5A)
STI  A   3 (-4.4A)
STI  A   3 (-3.9A)
STI  A   3 (-3.6A)
 0.61A 3zosA-1t46A:
34.3		 3zosA-1t46A:
32.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		10 LEU A 595
ALA A 621
LYS A 623
THR A 670
LEU A 783
HIS A 790
ARG A 791
LEU A 799
ASP A 810
PHE A 811
 STI  A   3 ( 3.8A)
STI  A   3 (-3.5A)
STI  A   3 (-3.7A)
STI  A   3 (-3.2A)
None
STI  A   3 (-4.5A)
None
STI  A   3 (-4.4A)
STI  A   3 (-3.9A)
STI  A   3 (-3.6A)
 0.72A 3zosA-1t46A:
34.3		 3zosA-1t46A:
32.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u5q SERINE/THREONINE
PROTEIN KINASE TAO2

(Rattus
norvegicus) 		PF00069
(Pkinase) 		7 ALA A  55
LYS A  57
GLU A  76
LEU A 142
HIS A 149
ARG A 150
LEU A 158
 None
None
None
None
None
SEP  A 181 ( 2.8A)
None
 0.79A 3zosA-1u5qA:
23.1		 3zosA-1u5qA:
26.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1

(Homo sapiens) 		PF00069
(Pkinase) 		8 LEU A  15
ALA A  36
LYS A  38
GLU A  55
LEU A 121
HIS A 128
ARG A 129
LEU A 137
 HYM  A 400 (-4.2A)
HYM  A 400 (-3.5A)
HYM  A 400 (-3.2A)
None
None
None
SO4  A 901 (-2.9A)
HYM  A 400 (-4.5A)
 0.79A 3zosA-1zltA:
20.1		 3zosA-1zltA:
24.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU X  17
ALA X  37
LYS X  39
GLU X  54
THR X  82
ARG X 129
LEU X 137
ALA X 147
 STU  X 902 (-3.8A)
STU  X 902 (-3.1A)
STU  X 902 (-3.1A)
STU  X 902 ( 4.4A)
STU  X 902 (-4.1A)
PTR  X 160 ( 3.4A)
STU  X 902 (-4.4A)
STU  X 902 ( 4.1A)
 0.85A 3zosA-2dq7X:
29.9		 3zosA-2dq7X:
35.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU X  17
ALA X  37
LYS X  39
THR X  82
HIS X 128
ARG X 129
LEU X 137
ALA X 147
 STU  X 902 (-3.8A)
STU  X 902 (-3.1A)
STU  X 902 (-3.1A)
STU  X 902 (-4.1A)
None
PTR  X 160 ( 3.4A)
STU  X 902 (-4.4A)
STU  X 902 ( 4.1A)
 0.84A 3zosA-2dq7X:
29.9		 3zosA-2dq7X:
35.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eu9 DUAL SPECIFICITY
PROTEIN KINASE CLK3

(Homo sapiens) 		PF00069
(Pkinase) 		8 LEU A 162
ALA A 184
LYS A 186
GLU A 201
LEU A 274
HIS A 281
LEU A 290
ALA A 319
 None
 0.76A 3zosA-2eu9A:
20.8		 3zosA-2eu9A:
24.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hk5 TYROSINE-PROTEIN
KINASE HCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 ALA A 271
LYS A 273
GLU A 288
THR A 316
HIS A 362
ARG A 363
LEU A 371
ALA A 381
 1BM  A 499 (-3.6A)
1BM  A 499 (-3.8A)
1BM  A 499 (-3.2A)
1BM  A 499 (-3.2A)
None
None
1BM  A 499 (-4.4A)
1BM  A 499 ( 3.7A)
 1.01A 3zosA-2hk5A:
29.6		 3zosA-2hk5A:
35.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hk5 TYROSINE-PROTEIN
KINASE HCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 251
ALA A 271
LYS A 273
GLU A 288
THR A 316
HIS A 362
LEU A 371
ALA A 381
 1BM  A 499 ( 3.7A)
1BM  A 499 (-3.6A)
1BM  A 499 (-3.8A)
1BM  A 499 (-3.2A)
1BM  A 499 (-3.2A)
None
1BM  A 499 (-4.4A)
1BM  A 499 ( 3.7A)
 0.96A 3zosA-2hk5A:
29.6		 3zosA-2hk5A:
35.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hk5 TYROSINE-PROTEIN
KINASE HCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 251
ALA A 271
LYS A 273
GLU A 288
THR A 316
LEU A 371
ALA A 381
ASP A 382
 1BM  A 499 ( 3.7A)
1BM  A 499 (-3.6A)
1BM  A 499 (-3.8A)
1BM  A 499 (-3.2A)
1BM  A 499 (-3.2A)
1BM  A 499 (-4.4A)
1BM  A 499 ( 3.7A)
1BM  A 499 (-4.4A)
 1.01A 3zosA-2hk5A:
29.6		 3zosA-2hk5A:
35.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		10 LEU A 248
ALA A 269
GLU A 286
THR A 315
HIS A 361
ARG A 362
LEU A 370
ALA A 380
ASP A 381
PHE A 382
 GIN  A 600 ( 4.6A)
GIN  A 600 (-3.1A)
GIN  A 600 (-3.6A)
GIN  A 600 (-3.4A)
GIN  A 600 (-4.3A)
None
GIN  A 600 (-4.7A)
GIN  A 600 (-3.1A)
GIN  A 600 (-4.9A)
GIN  A 600 (-4.0A)
 1.09A 3zosA-2hz0A:
29.9		 3zosA-2hz0A:
38.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 LEU A 248
ALA A 269
GLU A 286
THR A 315
LEU A 354
HIS A 361
LEU A 370
ALA A 380
ASP A 381
 GIN  A 600 ( 4.6A)
GIN  A 600 (-3.1A)
GIN  A 600 (-3.6A)
GIN  A 600 (-3.4A)
GIN  A 600 ( 4.6A)
GIN  A 600 (-4.3A)
GIN  A 600 (-4.7A)
GIN  A 600 (-3.1A)
GIN  A 600 (-4.9A)
 0.77A 3zosA-2hz0A:
29.9		 3zosA-2hz0A:
38.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		10 LEU A 248
ALA A 269
LYS A 271
GLU A 286
THR A 315
HIS A 361
ARG A 362
LEU A 370
ALA A 380
PHE A 382
 GIN  A 600 ( 4.6A)
GIN  A 600 (-3.1A)
GIN  A 600 (-3.6A)
GIN  A 600 (-3.6A)
GIN  A 600 (-3.4A)
GIN  A 600 (-4.3A)
None
GIN  A 600 (-4.7A)
GIN  A 600 (-3.1A)
GIN  A 600 (-4.0A)
 1.08A 3zosA-2hz0A:
29.9		 3zosA-2hz0A:
38.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 LEU A 248
ALA A 269
LYS A 271
GLU A 286
THR A 315
LEU A 354
HIS A 361
LEU A 370
ALA A 380
 GIN  A 600 ( 4.6A)
GIN  A 600 (-3.1A)
GIN  A 600 (-3.6A)
GIN  A 600 (-3.6A)
GIN  A 600 (-3.4A)
GIN  A 600 ( 4.6A)
GIN  A 600 (-4.3A)
GIN  A 600 (-4.7A)
GIN  A 600 (-3.1A)
 0.64A 3zosA-2hz0A:
29.9		 3zosA-2hz0A:
38.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2og8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		10 LEU A 251
ALA A 271
LYS A 273
GLU A 288
THR A 316
HIS A 362
LEU A 371
ALA A 381
ASP A 382
PHE A 383
 None
1N8  A 501 ( 3.4A)
1N8  A 501 ( 3.4A)
1N8  A 501 ( 3.6A)
1N8  A 501 ( 3.3A)
None
1N8  A 501 ( 4.3A)
1N8  A 501 ( 3.3A)
1N8  A 501 ( 3.3A)
1N8  A 501 ( 4.3A)
 0.67A 3zosA-2og8A:
31.1		 3zosA-2og8A:
37.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2og8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		10 LEU A 251
ALA A 271
LYS A 273
THR A 316
HIS A 362
ARG A 363
LEU A 371
ALA A 381
ASP A 382
PHE A 383
 None
1N8  A 501 ( 3.4A)
1N8  A 501 ( 3.4A)
1N8  A 501 ( 3.3A)
None
None
1N8  A 501 ( 4.3A)
1N8  A 501 ( 3.3A)
1N8  A 501 ( 3.3A)
1N8  A 501 ( 4.3A)
 0.85A 3zosA-2og8A:
31.1		 3zosA-2og8A:
37.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ogv MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
PRECURSOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 LEU A 588
ALA A 614
LYS A 616
GLU A 633
THR A 663
HIS A 776
ARG A 777
LEU A 785
ASP A 796
 None
 1.00A 3zosA-2ogvA:
32.5		 3zosA-2ogvA:
35.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ogv MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
PRECURSOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 LEU A 588
ALA A 614
LYS A 616
GLU A 633
THR A 663
LEU A 769
HIS A 776
LEU A 785
ASP A 796
 None
 0.84A 3zosA-2ogvA:
32.5		 3zosA-2ogvA:
35.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2p4i ANGIOPOIETIN-1
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 853
LEU A 955
HIS A 962
LEU A 971
ALA A 981
ASP A 982
PHE A 983
 MR9  A 301 (-3.5A)
MR9  A 301 (-4.4A)
MR9  A 301 (-4.5A)
MR9  A 301 (-4.5A)
MR9  A 301 (-3.2A)
MR9  A 301 (-4.2A)
MR9  A 301 (-4.4A)
 0.62A 3zosA-2p4iA:
12.4		 3zosA-2p4iA:
33.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 487
ALA A 515
GLU A 534
LEU A 617
HIS A 624
ARG A 625
LEU A 633
ALA A 643
 None
None
None
None
None
SO4  A 303 ( 2.9A)
None
None
 0.92A 3zosA-2psqA:
23.7		 3zosA-2psqA:
33.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 487
ALA A 515
LYS A 517
GLU A 534
LEU A 617
HIS A 624
ARG A 625
ALA A 643
 None
None
None
None
None
None
SO4  A 303 ( 2.9A)
None
 0.96A 3zosA-2psqA:
23.7		 3zosA-2psqA:
33.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qlu ACTIVIN RECEPTOR
TYPE IIB

(Homo sapiens) 		PF00069
(Pkinase) 		7 ALA A 215
LYS A 217
THR A 265
LEU A 301
HIS A 319
LEU A 328
ALA A 338
 ADE  A 488 (-3.2A)
None
ADE  A 488 (-4.3A)
None
None
ADE  A 488 (-4.4A)
None
 0.67A 3zosA-2qluA:
23.7		 3zosA-2qluA:
25.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 724
ALA A 749
LYS A 751
THR A 796
LEU A 834
HIS A 841
ARG A 842
LEU A 850
 GW7  A   1 ( 4.2A)
GW7  A   1 (-3.3A)
GW7  A   1 (-3.9A)
GW7  A   1 (-4.0A)
None
None
None
GW7  A   1 (-4.2A)
 0.88A 3zosA-2r4bA:
28.2		 3zosA-2r4bA:
32.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xik SERINE/THREONINE
PROTEIN KINASE 25

(Homo sapiens) 		PF00069
(Pkinase) 		7 ALA A  47
GLU A  66
LEU A 131
HIS A 138
ARG A 139
LEU A 147
ALA A 157
 J60  A1294 (-3.3A)
None
None
None
TPO  A 174 ( 2.9A)
J60  A1294 (-4.8A)
J60  A1294 ( 4.2A)
 0.71A 3zosA-2xikA:
17.8		 3zosA-2xikA:
24.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 LEU A 484
ALA A 512
GLU A 531
LEU A 614
HIS A 621
ARG A 622
LEU A 630
ALA A 640
PHE A 489
 C4F  A   1 ( 3.9A)
C4F  A   1 (-3.3A)
None
None
None
None
C4F  A   1 (-4.6A)
C4F  A   1 (-3.6A)
C4F  A   1 (-3.7A)
 0.90A 3zosA-3c4fA:
24.5		 3zosA-3c4fA:
37.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3d7u TYROSINE-PROTEIN
KINASE CSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 ALA A 220
LYS A 222
GLU A 236
THR A 266
LEU A 305
HIS A 312
ARG A 313
LEU A 321
 None
 0.62A 3zosA-3d7uA:
24.1		 3zosA-3d7uA:
32.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f2a PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  44
ALA A  65
LYS A  67
GLU A  89
HIS A 165
ARG A 166
LEU A 174
 985  A   1 (-4.1A)
985  A   1 (-3.5A)
985  A   1 ( 2.8A)
MG  A 314 (-3.6A)
None
None
985  A   1 (-4.8A)
 0.78A 3zosA-3f2aA:
15.5		 3zosA-3f2aA:
25.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		10 LEU A 833
ALA A 859
LYS A 861
GLU A 878
LEU A1013
HIS A1020
ARG A1021
LEU A1029
ASP A1040
PHE A1041
 8ST  A2001 ( 4.7A)
8ST  A2001 ( 3.8A)
8ST  A2001 (-4.0A)
8ST  A2001 (-3.7A)
8ST  A2001 (-4.6A)
8ST  A2001 ( 4.8A)
None
None
None
8ST  A2001 ( 3.7A)
 0.71A 3zosA-3hngA:
33.2		 3zosA-3hngA:
30.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kul EPHRIN TYPE-A
RECEPTOR 8

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		8 ALA A 665
LYS A 667
GLU A 684
THR A 713
LEU A 751
HIS A 758
ARG A 759
LEU A 767
 None
 1.08A 3zosA-3kulA:
24.4		 3zosA-3kulA:
37.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lij CALCIUM/CALMODULIN
DEPENDENT PROTEIN
KINASE WITH A KINASE
DOMAIN AND 4
CALMODULIN LIKE EF
HANDS

(Cryptosporidium
parvum) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		7 LEU A  68
ALA A  89
LYS A  91
LEU A 175
HIS A 182
ARG A 183
LEU A 191
 ANP  A 522 (-4.6A)
ANP  A 522 (-3.6A)
ANP  A 522 (-3.5A)
None
None
None
ANP  A 522 (-4.7A)
 0.77A 3zosA-3lijA:
23.2		 3zosA-3lijA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lj0 SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A) 		8 LEU A 680
ALA A 700
LYS A 702
GLU A 715
LEU A 788
HIS A 795
ARG A 796
LEU A 804
 ADP  A2101 ( 4.1A)
ADP  A2101 (-3.5A)
ADP  A2101 (-2.7A)
None
None
None
TPO  A 844 ( 3.0A)
ADP  A2101 (-4.4A)
 0.98A 3zosA-3lj0A:
20.9		 3zosA-3lj0A:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF08515
(TGF_beta_GS) 		9 ALA A 229
LYS A 231
GLU A 244
THR A 279
LEU A 315
HIS A 330
ARG A 331
LEU A 339
ALA A 349
 LDN  A   1 (-3.6A)
None
None
LDN  A   1 (-3.8A)
None
None
None
LDN  A   1 (-4.5A)
LDN  A   1 ( 3.8A)
 1.01A 3zosA-3mdyA:
23.6		 3zosA-3mdyA:
24.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mi9 CELL DIVISION
PROTEIN KINASE 9

(Homo sapiens) 		PF00069
(Pkinase) 		7 ALA A  46
LYS A  48
GLU A  66
HIS A 147
ARG A 148
LEU A 156
ALA A 166
 None
None
None
None
TPO  A 186 ( 2.8A)
None
None
 0.68A 3zosA-3mi9A:
14.9		 3zosA-3mi9A:
25.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 ALA A 227
LYS A 229
THR A 277
LEU A 313
HIS A 328
ARG A 329
LEU A 337
ALA A 347
 LDN  A 600 (-3.2A)
LDN  A 600 (-4.0A)
LDN  A 600 (-4.0A)
None
None
None
LDN  A 600 (-4.6A)
LDN  A 600 ( 3.8A)
 0.95A 3zosA-3my0A:
23.7		 3zosA-3my0A:
27.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nuu PKB-LIKE

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  88
ALA A 109
LYS A 111
GLU A 130
HIS A 203
LEU A 212
ASP A 223
 JOZ  A 361 (-4.1A)
JOZ  A 361 (-3.4A)
SO4  A   5 (-2.8A)
SO4  A   5 (-3.1A)
None
None
SO4  A   5 ( 4.5A)
 0.81A 3zosA-3nuuA:
22.7		 3zosA-3nuuA:
25.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nuu PKB-LIKE

(Homo sapiens) 		PF00069
(Pkinase) 		8 LEU A  88
ALA A 109
LYS A 111
GLU A 130
LEU A 196
HIS A 203
ARG A 204
LEU A 212
 JOZ  A 361 (-4.1A)
JOZ  A 361 (-3.4A)
SO4  A   5 (-2.8A)
SO4  A   5 (-3.1A)
None
None
SEP  A 241 ( 3.4A)
None
 0.81A 3zosA-3nuuA:
22.7		 3zosA-3nuuA:
25.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1

(Arabidopsis
thaliana) 		PF07714
(Pkinase_Tyr) 		7 ALA A 576
LYS A 578
GLU A 596
THR A 625
LEU A 665
HIS A 674
LEU A 683
 STU  A   1 (-3.3A)
STU  A   1 (-3.5A)
None
STU  A   1 (-4.1A)
None
None
STU  A   1 (-4.3A)
 0.59A 3zosA-3ppzA:
27.3		 3zosA-3ppzA:
31.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q4t ACTIVIN RECEPTOR
TYPE-2A

(Homo sapiens) 		PF00069
(Pkinase) 		8 ALA A 217
LYS A 219
THR A 267
LEU A 303
HIS A 320
ARG A 321
LEU A 329
ALA A 339
 TAK  A   2 (-3.5A)
TAK  A   2 (-2.9A)
TAK  A   2 (-3.5A)
None
None
None
TAK  A   2 (-4.6A)
TAK  A   2 ( 4.2A)
 1.02A 3zosA-3q4tA:
22.9		 3zosA-3q4tA:
26.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q5i PROTEIN KINASE

(Plasmodium
berghei) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		9 LEU A  63
ALA A  84
LYS A  86
GLU A 115
THR A 144
LEU A 181
HIS A 188
ARG A 189
LEU A 197
 ANP  A1634 ( 4.3A)
ANP  A1634 (-3.6A)
ANP  A1634 (-3.1A)
None
ANP  A1634 (-4.6A)
None
None
None
ANP  A1634 (-4.4A)
 0.75A 3zosA-3q5iA:
20.4		 3zosA-3q5iA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s95 LIM DOMAIN KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 LEU A 345
LYS A 368
GLU A 384
THR A 413
LEU A 451
HIS A 458
ARG A 459
LEU A 467
ALA A 477
 STU  A   1 (-3.8A)
STU  A   1 (-3.1A)
STU  A   1 (-3.7A)
STU  A   1 (-3.9A)
None
None
None
STU  A   1 (-4.6A)
STU  A   1 ( 4.1A)
 0.94A 3zosA-3s95A:
24.1		 3zosA-3s95A:
29.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3she MAP KINASE-ACTIVATED
PROTEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		8 LEU A  50
ALA A  71
LYS A  73
GLU A  84
LEU A 157
HIS A 164
ARG A 165
LEU A 173
 I85  A 350 (-3.7A)
I85  A 350 (-3.3A)
I85  A 350 (-2.8A)
None
None
None
None
None
 1.09A 3zosA-3sheA:
17.9		 3zosA-3sheA:
24.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3tt0 BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 484
ALA A 512
LYS A 514
GLU A 531
LEU A 614
HIS A 621
LEU A 630
ALA A 640
 07J  A   1 ( 4.3A)
07J  A   1 (-3.5A)
07J  A   1 (-4.5A)
07J  A   1 (-3.8A)
None
None
07J  A   1 ( 4.4A)
07J  A   1 (-3.2A)
 0.67A 3zosA-3tt0A:
30.3		 3zosA-3tt0A:
31.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3txo PROTEIN KINASE C ETA
TYPE

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		8 LEU A 361
ALA A 382
LYS A 384
GLU A 403
LEU A 470
ARG A 478
LEU A 486
ALA A 496
 07U  A   1 ( 4.8A)
07U  A   1 (-3.3A)
07U  A   1 (-3.0A)
07U  A   1 ( 4.8A)
None
None
07U  A   1 (-4.3A)
07U  A   1 ( 4.0A)
 1.07A 3zosA-3txoA:
12.9		 3zosA-3txoA:
25.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 840
ALA A 866
GLU A 885
LEU A1019
HIS A1026
ARG A1027
LEU A1035
ASP A1046
 4TT  A2001 ( 4.0A)
4TT  A2001 (-3.5A)
None
None
None
None
4TT  A2001 (-4.8A)
None
 0.71A 3zosA-3vidA:
30.0		 3zosA-3vidA:
31.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zfx EPHRIN TYPE-B
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 649
LYS A 651
THR A 697
LEU A 735
HIS A 742
ARG A 743
LEU A 751
 None
 0.84A 3zosA-3zfxA:
30.5		 3zosA-3zfxA:
37.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 LEU A 840
ALA A 866
LYS A 868
GLU A 885
LEU A1019
HIS A1026
LEU A1035
ASP A1046
PHE A1047
 B49  A2000 (-3.7A)
B49  A2000 (-3.5A)
B49  A2000 (-3.0A)
None
None
None
B49  A2000 (-4.5A)
None
B49  A2000 (-4.0A)
 0.85A 3zosA-4agdA:
33.1		 3zosA-4agdA:
30.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c02 ACTIVIN RECEPTOR
TYPE-1

(Homo sapiens) 		PF00069
(Pkinase)
PF08515
(TGF_beta_GS) 		7 ALA A 233
LYS A 235
THR A 283
LEU A 319
HIS A 334
LEU A 343
ALA A 353
 TAK  A1507 (-3.3A)
TAK  A1507 ( 4.5A)
TAK  A1507 (-3.6A)
None
None
TAK  A1507 (-4.7A)
TAK  A1507 ( 4.2A)
 0.76A 3zosA-4c02A:
23.7		 3zosA-4c02A:
28.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ckr EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		10 LEU A 616
ALA A 653
GLU A 672
LEU A 757
HIS A 764
ARG A 765
LEU A 773
ALA A 783
ASP A 784
PHE A 785
 None
DI1  A1000 (-3.6A)
DI1  A1000 (-3.8A)
DI1  A1000 (-4.4A)
DI1  A1000 (-3.8A)
None
DI1  A1000 (-4.5A)
DI1  A1000 (-3.7A)
DI1  A1000 (-4.1A)
DI1  A1000 (-4.5A)
 0.96A 3zosA-4ckrA:
34.5		 3zosA-4ckrA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ckr EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		10 LEU A 616
ALA A 653
GLU A 672
THR A 701
LEU A 757
HIS A 764
LEU A 773
ALA A 783
ASP A 784
PHE A 785
 None
DI1  A1000 (-3.6A)
DI1  A1000 (-3.8A)
DI1  A1000 (-3.6A)
DI1  A1000 (-4.4A)
DI1  A1000 (-3.8A)
DI1  A1000 (-4.5A)
DI1  A1000 (-3.7A)
DI1  A1000 (-4.1A)
DI1  A1000 (-4.5A)
 0.70A 3zosA-4ckrA:
34.5		 3zosA-4ckrA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ckr EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		10 LEU A 616
ALA A 653
LYS A 655
GLU A 672
LEU A 757
HIS A 764
ARG A 765
LEU A 773
ALA A 783
ASP A 784
 None
DI1  A1000 (-3.6A)
DI1  A1000 (-3.9A)
DI1  A1000 (-3.8A)
DI1  A1000 (-4.4A)
DI1  A1000 (-3.8A)
None
DI1  A1000 (-4.5A)
DI1  A1000 (-3.7A)
DI1  A1000 (-4.1A)
 0.90A 3zosA-4ckrA:
34.5		 3zosA-4ckrA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ckr EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		10 LEU A 616
ALA A 653
LYS A 655
GLU A 672
THR A 701
LEU A 757
HIS A 764
LEU A 773
ALA A 783
ASP A 784
 None
DI1  A1000 (-3.6A)
DI1  A1000 (-3.9A)
DI1  A1000 (-3.8A)
DI1  A1000 (-3.6A)
DI1  A1000 (-4.4A)
DI1  A1000 (-3.8A)
DI1  A1000 (-4.5A)
DI1  A1000 (-3.7A)
DI1  A1000 (-4.1A)
 0.58A 3zosA-4ckrA:
34.5		 3zosA-4ckrA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4crs SERINE/THREONINE-PRO
TEIN KINASE N2

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		8 LEU A 663
ALA A 684
LYS A 686
GLU A 705
LEU A 773
ARG A 781
LEU A 789
ALA A 799
 AGS  A1985 (-4.2A)
AGS  A1985 (-3.5A)
AGS  A1985 (-3.0A)
None
None
TPO  A 816 ( 3.0A)
AGS  A1985 (-4.8A)
AGS  A1985 ( 4.5A)
 0.84A 3zosA-4crsA:
20.6		 3zosA-4crsA:
24.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eut SERINE/THREONINE-PRO
TEIN KINASE TBK1

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  15
ALA A  36
LYS A  38
GLU A  55
LEU A 126
HIS A 133
ARG A 134
 BX7  A 401 (-3.7A)
BX7  A 401 (-3.4A)
BX7  A 401 ( 4.0A)
None
None
None
None
 0.70A 3zosA-4eutA:
10.8		 3zosA-4eutA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4euu SERINE/THREONINE-PRO
TEIN KINASE TBK1

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  15
ALA A  36
LYS A  38
GLU A  55
LEU A 126
HIS A 133
ARG A 134
 BX7  A 401 (-3.9A)
BX7  A 401 (-3.4A)
BX7  A 401 (-3.5A)
None
None
None
SEP  A 172 ( 2.7A)
 0.71A 3zosA-4euuA:
14.0		 3zosA-4euuA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ez5 CYCLIN-DEPENDENT
KINASE 6

(Homo sapiens) 		PF00069
(Pkinase) 		7 ALA A  41
LYS A  43
LEU A 136
HIS A 143
ARG A 144
LEU A 152
ALA A 162
 0RS  A 900 ( 3.7A)
0RS  A 900 (-3.3A)
None
None
None
0RS  A 900 (-4.3A)
0RS  A 900 (-3.6A)
 0.76A 3zosA-4ez5A:
21.5		 3zosA-4ez5A:
28.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4gl9 TYROSINE-PROTEIN
KINASE

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		8 LEU A 855
ALA A 880
LYS A 882
GLU A 898
LEU A 967
HIS A 974
ARG A 975
LEU A 983
 IZA  A2001 (-3.7A)
IZA  A2001 (-3.4A)
IZA  A2001 ( 4.7A)
None
None
None
None
IZA  A2001 ( 4.7A)
 1.05A 3zosA-4gl9A:
28.0		 3zosA-4gl9A:
33.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hvi TYROSINE-PROTEIN
KINASE JAK3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 828
ALA A 853
LYS A 855
GLU A 871
LEU A 940
HIS A 947
LEU A 956
ALA A 966
 19S  A1201 (-3.9A)
19S  A1201 (-3.3A)
19S  A1201 (-3.5A)
None
None
None
19S  A1201 (-4.5A)
19S  A1201 ( 4.1A)
 0.53A 3zosA-4hviA:
22.8		 3zosA-4hviA:
33.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4idt MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 14

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A 406
ALA A 427
LYS A 429
GLU A 440
LEU A 506
HIS A 513
LEU A 522
 T28  A 701 (-3.8A)
T28  A 701 (-3.0A)
T28  A 701 ( 3.8A)
None
None
None
T28  A 701 (-3.9A)
 0.72A 3zosA-4idtA:
21.1		 3zosA-4idtA:
22.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4k33 FIBROBLAST GROWTH
FACTOR RECEPTOR 3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 LEU A 478
ALA A 506
LYS A 508
GLU A 525
LEU A 608
HIS A 615
ARG A 616
LEU A 624
ALA A 634
 ACP  A 801 (-3.8A)
ACP  A 801 (-3.3A)
ACP  A 801 (-2.7A)
ACP  A 801 ( 4.8A)
None
None
None
ACP  A 801 (-4.4A)
None
 1.00A 3zosA-4k33A:
30.4		 3zosA-4k33A:
34.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m69 RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 3

(Mus musculus) 		PF00069
(Pkinase) 		7 ALA A  49
LYS A  51
THR A  95
LEU A 132
HIS A 141
LEU A 150
ALA A 160
 ANP  A 401 (-3.1A)
ANP  A 401 (-2.9A)
ANP  A 401 (-3.8A)
None
None
ANP  A 401 (-4.8A)
None
 0.79A 3zosA-4m69A:
22.0		 3zosA-4m69A:
27.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o27 SERINE/THREONINE-PRO
TEIN KINASE 24

(Homo sapiens) 		PF00069
(Pkinase) 		8 ALA B  51
LYS B  53
GLU B  70
LEU B 135
HIS B 142
ARG B 143
LEU B 151
ALA B 161
 ADP  B 500 (-3.3A)
ADP  B 500 (-3.1A)
None
None
None
None
ADP  B 500 (-4.7A)
None
 0.71A 3zosA-4o27B:
17.3		 3zosA-4o27B:
26.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o38 CYCLIN-G-ASSOCIATED
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		8 LEU A  46
ALA A  67
LYS A  69
GLU A  85
THR A 123
HIS A 171
ARG A 172
LEU A 180
 SIN  A 401 ( 3.9A)
SIN  A 401 ( 3.7A)
None
None
None
None
None
SIN  A 401 ( 4.5A)
 0.75A 3zosA-4o38A:
19.9		 3zosA-4o38A:
25.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		10 LEU A 616
ALA A 642
LYS A 644
GLU A 661
LEU A 802
HIS A 809
ARG A 810
LEU A 818
ASP A 829
PHE A 830
 P30  A1001 (-3.8A)
P30  A1001 (-3.4A)
P30  A1001 (-3.4A)
P30  A1001 (-3.6A)
None
P30  A1001 ( 4.3A)
None
P30  A1001 (-4.6A)
None
P30  A1001 (-3.9A)
 0.76A 3zosA-4rt7A:
27.4		 3zosA-4rt7A:
28.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tpt LIM DOMAIN KINASE 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 THR A 405
LEU A 442
HIS A 449
ARG A 450
LEU A 458
ALA A 468
ASP A 469
PHE A 470
 35H  A 701 (-3.8A)
35H  A 701 ( 4.7A)
35H  A 701 ( 4.4A)
None
None
35H  A 701 (-3.5A)
35H  A 701 (-4.7A)
35H  A 701 (-4.4A)
 1.10A 3zosA-4tptA:
20.5		 3zosA-4tptA:
29.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL

(synthetic
construct) 		PF07714
(Pkinase_Tyr) 		9 LEU A  14
ALA A  35
LYS A  37
GLU A  52
THR A  81
HIS A 127
LEU A 136
ALA A 146
ASP A 147
 ACP  A1264 ( 4.5A)
ACP  A1264 (-2.9A)
None
None
ACP  A1264 (-4.5A)
None
ACP  A1264 ( 4.8A)
None
None
 0.96A 3zosA-4ueuA:
30.1		 3zosA-4ueuA:
39.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wsq AP2-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  52
ALA A  72
GLU A  90
LEU A 165
HIS A 174
ARG A 175
LEU A 183
 KSA  A 405 ( 4.0A)
KSA  A 405 (-3.2A)
None
None
None
None
KSA  A 405 (-4.6A)
 0.84A 3zosA-4wsqA:
21.8		 3zosA-4wsqA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xbr PROTEIN
FAM212A,SERINE/THREO
NINE-PROTEIN KINASE
PAK 4

(Homo sapiens) 		PF00069
(Pkinase)
PF15342
(FAM212) 		7 ALA A 348
LYS A 350
GLU A 366
LEU A 431
HIS A 438
ARG A 439
LEU A 447
 ATP  A 601 ( 3.7A)
ATP  A 601 (-2.8A)
ATP  A 601 ( 3.7A)
None
None
SEP  A 474 ( 3.2A)
None
 0.77A 3zosA-4xbrA:
15.3		 3zosA-4xbrA:
23.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xcu FIBROBLAST GROWTH
FACTOR RECEPTOR 4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 473
ALA A 501
LYS A 503
GLU A 520
LEU A 603
HIS A 610
LEU A 619
ALA A 629
 40M  A1002 ( 4.6A)
40M  A1002 ( 4.1A)
40M  A1002 (-4.0A)
40M  A1002 (-3.7A)
None
None
40M  A1002 (-4.5A)
40M  A1002 (-3.0A)
 0.69A 3zosA-4xcuA:
29.7		 3zosA-4xcuA:
38.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xey TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		no annotation 7 LEU B 267
ALA B 288
LYS B 290
THR B 334
HIS B 380
LEU B 389
ALA B 399
 1N1  B 601 (-3.7A)
1N1  B 601 (-3.5A)
1N1  B 601 (-4.6A)
1N1  B 601 (-3.3A)
None
1N1  B 601 (-4.3A)
1N1  B 601 (-3.5A)
 0.81A 3zosA-4xeyB:
29.8		 3zosA-4xeyB:
29.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 LEU A 616
ALA A 642
LYS A 644
GLU A 661
HIS A 809
ARG A 810
LEU A 818
ASP A 829
PHE A 830
 P30  A1001 (-4.0A)
P30  A1001 (-3.5A)
P30  A1001 ( 4.0A)
P30  A1001 (-3.1A)
P30  A1001 (-4.4A)
None
P30  A1001 (-4.3A)
None
P30  A1001 ( 4.1A)
 1.10A 3zosA-4xufA:
33.1		 3zosA-4xufA:
33.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 LEU A 616
ALA A 642
LYS A 644
GLU A 661
LEU A 802
HIS A 809
LEU A 818
ASP A 829
PHE A 830
 P30  A1001 (-4.0A)
P30  A1001 (-3.5A)
P30  A1001 ( 4.0A)
P30  A1001 (-3.1A)
None
P30  A1001 (-4.4A)
P30  A1001 (-4.3A)
None
P30  A1001 ( 4.1A)
 0.76A 3zosA-4xufA:
33.1		 3zosA-4xufA:
33.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE

(Bos taurus) 		PF00169
(PH)
PF00779
(BTK)
PF07714
(Pkinase_Tyr) 		8 LEU A 408
ALA A 428
LYS A 430
THR A 474
LEU A 512
HIS A 519
ARG A 520
LEU A 528
 746  A 702 (-3.8A)
746  A 702 (-2.4A)
746  A 702 (-3.7A)
746  A 702 (-3.7A)
None
None
None
746  A 702 (-4.4A)
 0.84A 3zosA-4y93A:
29.4		 3zosA-4y93A:
24.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yff SERINE/THREONINE-PRO
TEIN KINASE TNNI3K

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 488
LYS A 490
GLU A 509
THR A 539
LEU A 577
LEU A 595
ALA A 605
 4CV  A 801 (-3.5A)
4CV  A 801 (-3.9A)
None
4CV  A 801 (-2.8A)
None
4CV  A 801 (-4.4A)
4CV  A 801 ( 3.9A)
 0.69A 3zosA-4yffA:
23.9		 3zosA-4yffA:
29.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE

(Eimeria tenella) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		8 LEU A  34
ALA A  55
LYS A  57
GLU A  76
THR A 105
HIS A 149
ARG A 150
LEU A 158
 ADP  A 506 ( 3.8A)
ADP  A 506 (-3.3A)
ADP  A 506 (-2.4A)
None
ADP  A 506 ( 4.6A)
None
None
ADP  A 506 (-4.7A)
 0.84A 3zosA-4ysjA:
22.4		 3zosA-4ysjA:
21.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 LEU A 484
ALA A 512
LYS A 514
GLU A 531
LEU A 614
HIS A 621
ARG A 622
LEU A 630
ALA A 640
 38O  A1769 (-3.2A)
38O  A1769 (-3.6A)
38O  A1769 ( 3.1A)
EDO  A1766 (-4.1A)
None
None
None
38O  A1769 (-4.6A)
EDO  A1766 ( 4.4A)
 0.65A 3zosA-5a46A:
30.7		 3zosA-5a46A:
31.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ci7 SERINE/THREONINE-PRO
TEIN KINASE ULK1

(Homo sapiens) 		PF00069
(Pkinase) 		7 ALA A  44
LYS A  46
LEU A 129
HIS A 136
ARG A 137
LEU A 145
ALA A 164
 51W  A 401 (-3.4A)
GOL  A 404 ( 3.1A)
None
None
TPO  A 180 ( 2.9A)
51W  A 401 (-4.5A)
None
 0.83A 3zosA-5ci7A:
22.4		 3zosA-5ci7A:
27.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e8y TGF-BETA RECEPTOR
TYPE-2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 ALA A 275
LYS A 277
GLU A 290
THR A 325
LEU A 361
HIS A 377
ARG A 378
LEU A 386
 STU  A 601 (-3.1A)
STU  A 601 (-2.4A)
STU  A 601 ( 3.8A)
STU  A 601 ( 3.7A)
None
None
None
STU  A 601 (-3.9A)
 0.78A 3zosA-5e8yA:
23.7		 3zosA-5e8yA:
26.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 903
ALA A 928
LYS A 930
GLU A 947
LEU A1014
HIS A1021
ARG A1022
LEU A1030
 5U3  A1200 (-3.8A)
5U3  A1200 (-3.5A)
None
None
None
None
None
5U3  A1200 (-4.4A)
 1.19A 3zosA-5f1zA:
27.1		 3zosA-5f1zA:
34.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		10 LEU A 599
ALA A 625
LYS A 627
GLU A 644
THR A 674
LEU A 809
HIS A 816
LEU A 825
ASP A 836
PHE A 837
 748  A1001 (-3.8A)
748  A1001 (-3.7A)
748  A1001 (-4.0A)
748  A1001 (-3.3A)
748  A1001 (-3.2A)
748  A1001 ( 4.6A)
748  A1001 (-3.8A)
748  A1001 (-4.3A)
748  A1001 (-4.8A)
748  A1001 (-3.7A)
 0.55A 3zosA-5grnA:
28.0		 3zosA-5grnA:
30.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 599
LYS A 627
GLU A 644
LEU A 809
HIS A 816
ARG A 817
LEU A 825
ASP A 836
 748  A1001 (-3.8A)
748  A1001 (-4.0A)
748  A1001 (-3.3A)
748  A1001 ( 4.6A)
748  A1001 (-3.8A)
None
748  A1001 (-4.3A)
748  A1001 (-4.8A)
 0.73A 3zosA-5grnA:
28.0		 3zosA-5grnA:
30.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN

(Drosophila
melanogaster) 		PF00069
(Pkinase) 		8 LEU A  20
ALA A  41
LYS A  43
GLU A  61
HIS A 134
ARG A 135
LEU A 143
ALA A 156
 ADP  A 301 ( 4.0A)
ADP  A 301 (-3.5A)
ADP  A 301 (-2.7A)
None
None
None
ADP  A 301 (-4.7A)
ADP  A 301 ( 4.8A)
 0.90A 3zosA-5hu3A:
22.5		 3zosA-5hu3A:
25.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5idn CYCLIN-DEPENDENT
KINASE 8

(Homo sapiens) 		PF00069
(Pkinase) 		7 ALA A  50
LYS A  52
LEU A 142
HIS A 149
ARG A 150
LEU A 158
ALA A 172
 6A7  A 401 (-3.3A)
6A7  A 401 ( 2.9A)
None
FMT  A 403 (-4.6A)
None
6A7  A 401 (-4.8A)
6A7  A 401 ( 4.1A)
 0.67A 3zosA-5idnA:
20.5		 3zosA-5idnA:
26.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3

(Homo sapiens) 		PF00069
(Pkinase) 		7 ALA A  43
LYS A  45
GLU A  61
LEU A 127
HIS A 134
LEU A 143
ALA A 153
 6G2  A 901 (-3.2A)
6G2  A 901 ( 3.9A)
None
None
None
6G2  A 901 (-4.7A)
6G2  A 901 ( 4.2A)
 0.65A 3zosA-5j5tA:
21.0		 3zosA-5j5tA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5myv SRSF PROTEIN KINASE
2,SRSF PROTEIN
KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		7 ALA A 119
LYS A 121
GLU A 136
LEU A 215
HIS A 223
LEU A 232
ALA A 540
 W4A  A 716 ( 3.9A)
SO4  A 702 (-3.3A)
DMS  A 717 (-4.0A)
None
None
None
DMS  A 717 ( 4.5A)
 0.79A 3zosA-5myvA:
12.7		 3zosA-5myvA:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vil MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 5

(Homo sapiens) 		no annotation 8 LEU A 686
ALA A 707
LYS A 709
GLU A 725
LEU A 794
HIS A 801
ARG A 802
LEU A 810
 9E1  A1001 (-3.7A)
9E1  A1001 (-3.5A)
9E1  A1001 (-2.8A)
None
None
None
None
9E1  A1001 (-4.5A)
 0.77A 3zosA-5vilA:
18.1		 3zosA-5vilA:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w5j RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2

(Homo sapiens) 		no annotation 7 LEU A  24
ALA A  45
LYS A  47
THR A  95
LEU A 135
LEU A 153
ALA A 163
 9WS  A 401 ( 4.2A)
9WS  A 401 (-3.3A)
9WS  A 401 (-3.3A)
9WS  A 401 (-3.2A)
None
9WS  A 401 (-4.6A)
9WS  A 401 ( 4.0A)
 0.68A 3zosA-5w5jA:
22.1		 3zosA-5w5jA:
27.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xv7 SERINE-ARGININE (SR)
PROTEIN KINASE 1

(Homo sapiens) 		no annotation 7 ALA A 107
LYS A 109
GLU A 124
LEU A 203
HIS A 211
LEU A 220
ALA A 496
 EMH  A 705 (-3.6A)
EMH  A 705 ( 4.8A)
None
None
None
None
EMH  A 705 ( 4.0A)
 0.74A 3zosA-5xv7A:
20.3		 3zosA-5xv7A:
11.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ao5 SERINE/THREONINE-PRO
TEIN KINASE 3

(Homo sapiens) 		no annotation 7 LEU A  33
ALA A  54
LEU A 137
HIS A 144
ARG A 145
LEU A 153
ALA A 163
 ANP  A 501 ( 3.8A)
ANP  A 501 ( 3.7A)
None
None
None
ANP  A 501 (-4.6A)
None
 0.74A 3zosA-6ao5A:
20.9		 3zosA-6ao5A:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b3e CYCLIN-DEPENDENT
KINASE 12

(Homo sapiens) 		no annotation 7 ALA A 754
LYS A 756
GLU A 774
HIS A 857
ARG A 858
LEU A 866
ALA A 876
 CJM  A1102 (-3.1A)
None
None
None
TPO  A 893 ( 3.0A)
CJM  A1102 (-4.4A)
CJM  A1102 (-3.6A)
 0.76A 3zosA-6b3eA:
22.2		 3zosA-6b3eA:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c7y TYROSINE-PROTEIN
KINASE JAK1

(Homo sapiens) 		no annotation 8 LEU A 881
ALA A 906
LYS A 908
GLU A 925
LEU A 994
HIS A1001
ARG A1002
LEU A1010
 ADP  A1201 ( 4.5A)
ADP  A1201 (-3.4A)
ADP  A1201 (-2.8A)
None
None
None
None
ADP  A1201 (-4.5A)
 1.10A 3zosA-6c7yA:
19.9		 3zosA-6c7yA:
12.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cnh SERINE/THREONINE-PRO
TEIN KINASE PRP4
HOMOLOG

(Homo sapiens) 		no annotation 7 ALA A 715
GLU A 732
LEU A 806
HIS A 813
LEU A 822
ASP A 834
PHE A 835
 919  A1101 (-3.5A)
919  A1101 (-3.7A)
None
919  A1101 (-4.2A)
None
919  A1101 (-4.5A)
919  A1101 ( 4.1A)
 0.69A 3zosA-6cnhA:
21.1		 3zosA-6cnhA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cz4 PROTEIN-TYROSINE
KINASE 6

(Homo sapiens) 		no annotation 8 ALA A 217
THR A 264
LEU A 303
HIS A 310
ARG A 311
LEU A 319
ASP A 330
PHE A 331
 FKY  A9001 (-3.3A)
FKY  A9001 (-3.0A)
FKY  A9001 (-4.4A)
FKY  A9001 (-3.9A)
None
FKY  A9001 ( 4.9A)
None
FKY  A9001 (-3.9A)
 0.96A 3zosA-6cz4A:
27.8		 3zosA-6cz4A:
14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4

(Homo sapiens) 		no annotation 7 LEU A 167
ALA A 189
LYS A 191
GLU A 206
LEU A 279
HIS A 286
LEU A 295
 3NG  A 501 (-3.9A)
3NG  A 501 (-3.5A)
3NG  A 501 (-2.7A)
3NG  A 501 ( 4.7A)
None
None
None
 0.79A 3zosA-6fyvA:
20.9		 3zosA-6fyvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f82 BOTULINUM NEUROTOXIN
TYPE B

(Clostridium
botulinum) 		PF01742
(Peptidase_M27) 		5 MET A  91
ILE A  38
ILE A  44
TYR A  33
ILE A  42
 None
 1.10A 3zosA-1f82A:
undetectable		 3zosA-1f82A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fok PROTEIN (FOKI
RESTRICTION
ENDONUCLEASE)

(Planomicrobium
okeanokoites) 		PF02980
(FokI_C)
PF02981
(FokI_N)
PF09254
(Endonuc-FokI_C)
PF16902
(Type2_restr_D3) 		5 ILE A 313
LEU A 317
ILE A 358
ILE A 356
ILE A 352
 None
 1.02A 3zosA-1fokA:
undetectable		 3zosA-1fokA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fot CAMP-DEPENDENT
PROTEIN KINASE TYPE
1

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		5 ILE A 147
ILE A 148
MET A 162
TYR A 166
ILE A 226
 None
 0.63A 3zosA-1fotA:
21.3		 3zosA-1fotA:
25.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g5u PROFILIN

(Hevea
brasiliensis) 		PF00235
(Profilin) 		5 ILE A1083
ILE A1103
ILE A1102
TYR A1125
ILE A1026
 None
 0.97A 3zosA-1g5uA:
undetectable		 3zosA-1g5uA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gng GLYCOGEN SYNTHASE
KINASE-3 BETA

(Homo sapiens) 		PF00069
(Pkinase) 		5 ILE A 100
MET A 101
LEU A 104
ILE A 109
TYR A 134
 None
 0.62A 3zosA-1gngA:
20.2		 3zosA-1gngA:
23.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1luf MUSCLE-SPECIFIC
TYROSINE KINASE
RECEPTOR MUSK

(Rattus
norvegicus) 		PF07714
(Pkinase_Tyr) 		5 MET A 629
ILE A 637
TYR A 656
MET A 657
ILE A 740
 None
 0.69A 3zosA-1lufA:
28.5		 3zosA-1lufA:
39.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mc3 GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E

(Escherichia
coli) 		PF00483
(NTP_transferase) 		5 LEU A 104
ILE A   4
ILE A   5
TYR A  35
ILE A  52
 None
 1.03A 3zosA-1mc3A:
undetectable		 3zosA-1mc3A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mdf 2,3-DIHYDROXYBENZOAT
E-AMP LIGASE

(Bacillus
subtilis) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		5 ILE A  85
LEU A  82
ILE A 127
ILE A 128
ILE A 155
 None
 1.05A 3zosA-1mdfA:
undetectable		 3zosA-1mdfA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mp3 GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E

(Salmonella
enterica) 		PF00483
(NTP_transferase) 		5 LEU A 107
ILE A   7
ILE A   8
TYR A  38
ILE A  55
 None
 0.94A 3zosA-1mp3A:
undetectable		 3zosA-1mp3A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qzm ATP-DEPENDENT
PROTEASE LA

(Escherichia
coli) 		no annotation 5 ILE A 501
ILE A 532
ILE A 531
TYR A 578
ILE A 529
 None
 1.08A 3zosA-1qzmA:
undetectable		 3zosA-1qzmA:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1saw HYPOTHETICAL PROTEIN
FLJ36880

(Homo sapiens) 		PF01557
(FAA_hydrolase) 		5 MET A 165
ILE A 172
ILE A 169
MET A  91
ILE A 188
 None
 1.14A 3zosA-1sawA:
undetectable		 3zosA-1sawA:
20.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ILE X  57
MET X  58
TYR X  84
MET X  85
ILE X 146
 None
None
STU  X 902 (-4.6A)
None
None
 0.65A 3zosA-2dq7X:
29.9		 3zosA-2dq7X:
35.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gy7 ANGIOPOIETIN-2

(Homo sapiens) 		PF00147
(Fibrinogen_C) 		5 ILE A 309
LEU A 355
ILE A 325
ILE A 324
ILE A 491
 None
 1.07A 3zosA-2gy7A:
undetectable		 3zosA-2gy7A:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hak SERINE/THREONINE-PRO
TEIN KINASE MARK1

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		5 ILE A 103
LEU A 107
ILE A 112
TYR A 131
ILE A 191
 None
 0.66A 3zosA-2hakA:
20.3		 3zosA-2hakA:
26.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i6l MITOGEN-ACTIVATED
PROTEIN KINASE 6

(Homo sapiens) 		PF00069
(Pkinase) 		6 ILE A  68
LEU A  72
ILE A  77
TYR A 110
MET A 111
ILE A 169
 None
 0.81A 3zosA-2i6lA:
21.8		 3zosA-2i6lA:
27.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2inr DNA TOPOISOMERASE 4
SUBUNIT A

(Staphylococcus
aureus) 		PF00521
(DNA_topoisoIV) 		5 ILE A 209
MET A 206
ILE A 483
ILE A 223
ILE A 220
 None
 1.13A 3zosA-2inrA:
undetectable		 3zosA-2inrA:
21.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ogv MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
PRECURSOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ILE A 636
MET A 637
ILE A 646
TYR A 665
ILE A 794
 None
 0.93A 3zosA-2ogvA:
32.5		 3zosA-2ogvA:
35.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2p4i ANGIOPOIETIN-1
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 879
ILE A 885
ILE A 886
TYR A 904
ILE A 980
 MR9  A 301 (-4.1A)
MR9  A 301 ( 4.5A)
MR9  A 301 (-4.0A)
MR9  A 301 (-3.8A)
MR9  A 301 (-4.6A)
 0.72A 3zosA-2p4iA:
13.6		 3zosA-2p4iA:
33.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pk3 GDP-6-DEOXY-D-LYXO-4
-HEXULOSE REDUCTASE

(Aneurinibacillus
thermoaerophilus) 		PF16363
(GDP_Man_Dehyd) 		5 ILE A 112
LEU A 110
ILE A 163
ILE A 162
TYR A 158
 A2R  A 401 (-4.2A)
None
None
None
None
 1.09A 3zosA-2pk3A:
undetectable		 3zosA-2pk3A:
23.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 MET A 538
ILE A 547
ILE A 548
TYR A 566
ILE A 642
 None
 0.83A 3zosA-2psqA:
23.7		 3zosA-2psqA:
33.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qob EPHRIN RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ILE A 673
MET A 674
ILE A 682
ILE A 683
MET A 702
 None
None
None
None
PTR  A 701 ( 3.5A)
 0.77A 3zosA-2qobA:
24.3		 3zosA-2qobA:
34.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2r2p EPHRIN TYPE-A
RECEPTOR 5

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		6 ILE A 727
MET A 728
ILE A 736
ILE A 737
TYR A 755
MET A 756
 None
 0.65A 3zosA-2r2pA:
30.6		 3zosA-2r2pA:
35.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vxo GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG]

(Homo sapiens) 		PF00117
(GATase)
PF00958
(GMP_synt_C)
PF02540
(NAD_synthase) 		5 ILE A  54
ILE A  73
ILE A  74
MET A 110
ILE A 103
 None
 1.10A 3zosA-2vxoA:
undetectable		 3zosA-2vxoA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xk9 CHECKPOINT KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		5 ILE A 276
ILE A 285
ILE A 286
MET A 304
ILE A 366
 None
 0.56A 3zosA-2xk9A:
19.1		 3zosA-2xk9A:
26.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xk9 CHECKPOINT KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		5 ILE A 276
LEU A 280
ILE A 285
ILE A 286
ILE A 366
 None
 0.70A 3zosA-2xk9A:
19.1		 3zosA-2xk9A:
26.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2xyu EPHRIN TYPE-A
RECEPTOR 4,

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		5 ILE A 673
ILE A 682
ILE A 683
TYR A 701
MET A 702
 None
None
Q9G  A1898 ( 4.9A)
Q9G  A1898 (-4.8A)
None
 0.42A 3zosA-2xyuA:
24.2		 3zosA-2xyuA:
35.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2xyu EPHRIN TYPE-A
RECEPTOR 4,

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		5 ILE A 673
MET A 674
ILE A 683
TYR A 701
MET A 702
 None
Q9G  A1898 (-3.9A)
Q9G  A1898 ( 4.9A)
Q9G  A1898 (-4.8A)
None
 0.77A 3zosA-2xyuA:
24.2		 3zosA-2xyuA:
35.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y4o PHENYLACETATE-COENZY
ME A LIGASE

(Burkholderia
cenocepacia) 		PF00501
(AMP-binding)
PF14535
(AMP-binding_C_2) 		5 ILE A 151
LEU A 136
ILE A 184
ILE A 185
ILE A 213
 None
 0.88A 3zosA-2y4oA:
undetectable		 3zosA-2y4oA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b2n UNCHARACTERIZED
PROTEIN Q99UF4

(Staphylococcus
aureus) 		PF00072
(Response_reg) 		5 ILE A  78
ILE A  81
ILE A  82
TYR A  91
ILE A  54
 None
 1.09A 3zosA-3b2nA:
undetectable		 3zosA-3b2nA:
16.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 MET A 538
ILE A 547
ILE A 548
TYR A 566
ILE A 642
 None
None
None
M33  A1996 ( 4.7A)
None
 0.66A 3zosA-3b2tA:
23.4		 3zosA-3b2tA:
34.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE

(Trypanosoma
brucei) 		PF01048
(PNP_UDP_1) 		5 ILE A 290
ILE A  38
ILE A  39
TYR A  53
ILE A  83
 None
 1.02A 3zosA-3bjeA:
undetectable		 3zosA-3bjeA:
21.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 MET A 535
ILE A 544
ILE A 545
TYR A 563
ILE A 639
 C4F  A   1 ( 3.7A)
None
C4F  A   1 ( 4.0A)
None
None
 0.81A 3zosA-3c4fA:
24.5		 3zosA-3c4fA:
37.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e3b CASEIN KINASE II
SUBUNIT ALPHA'

(Homo sapiens) 		PF00069
(Pkinase) 		5 ILE X  85
LEU X  89
ILE X  95
ILE X  96
TYR X 116
 None
None
None
CCK  X 351 ( 4.6A)
CCK  X 351 (-4.3A)
 0.70A 3zosA-3e3bX:
12.1		 3zosA-3e3bX:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eb0 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		6 ILE A  53
MET A  54
LEU A  57
ILE A  62
ILE A  63
TYR A 119
 None
None
None
None
DRK  A 384 ( 4.5A)
DRK  A 384 (-4.4A)
 0.56A 3zosA-3eb0A:
21.1		 3zosA-3eb0A:
24.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fe3 MAP/MICROTUBULE
AFFINITY-REGULATING
KINASE 3

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		5 ILE A 106
LEU A 110
ILE A 115
TYR A 134
ILE A 194
 None
 0.88A 3zosA-3fe3A:
22.3		 3zosA-3fe3A:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h4j SNF1-LIKE PROTEIN
KINASE SSP2

(Schizosaccharomyces
pombe) 		no annotation 5 ILE B  94
ILE B  95
MET B 109
TYR B 113
ILE B 172
 None
 0.70A 3zosA-3h4jB:
9.1		 3zosA-3h4jB:
25.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		5 ILE A 103
LEU A 107
ILE A 112
TYR A 131
ILE A 191
 None
 0.81A 3zosA-3iecA:
22.0		 3zosA-3iecA:
26.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		5 ILE A 103
MET A 104
ILE A 112
TYR A 131
ILE A 191
 None
 0.97A 3zosA-3iecA:
22.0		 3zosA-3iecA:
26.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kul EPHRIN TYPE-A
RECEPTOR 8

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		6 ILE A 687
MET A 688
ILE A 696
ILE A 697
TYR A 715
MET A 716
 None
None
None
None
GOL  A 403 (-4.1A)
None
 0.83A 3zosA-3kulA:
24.4		 3zosA-3kulA:
37.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ll3 GLUCONATE KINASE

(Lactobacillus
acidophilus) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		5 ILE A  65
LEU A  18
ILE A   5
ILE A   4
ILE A  72
 None
 1.00A 3zosA-3ll3A:
undetectable		 3zosA-3ll3A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m1m ORF904

(Sulfolobus
islandicus) 		PF09250
(Prim-Pol)
PF13010
(pRN1_helical) 		5 ILE A 331
LEU A 334
ILE A 296
ILE A 295
ILE A 292
 None
 1.08A 3zosA-3m1mA:
undetectable		 3zosA-3m1mA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3me8 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Aquifex
aeolicus) 		PF02630
(SCO1-SenC) 		5 ILE A 113
LEU A 133
ILE A  31
ILE A  32
ILE A  68
 None
 1.04A 3zosA-3me8A:
undetectable		 3zosA-3me8A:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mn3 CARBON
CATABOLITE-DEREPRESS
ING PROTEIN KINASE

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		5 ILE A 115
ILE A 116
MET A 130
TYR A 134
ILE A 193
 None
 0.65A 3zosA-3mn3A:
20.3		 3zosA-3mn3A:
29.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mn3 CARBON
CATABOLITE-DEREPRESS
ING PROTEIN KINASE

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		5 LEU A 110
ILE A 115
ILE A 116
TYR A 134
ILE A 193
 None
 0.52A 3zosA-3mn3A:
20.3		 3zosA-3mn3A:
29.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3op1 MACROLIDE-EFFLUX
PROTEIN

(Streptococcus
pneumoniae) 		PF01687
(Flavokinase)
PF06574
(FAD_syn) 		5 ILE A  51
ILE A 122
ILE A 123
TYR A 144
ILE A 150
 None
 0.94A 3zosA-3op1A:
undetectable		 3zosA-3op1A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pm9 PUTATIVE
OXIDOREDUCTASE

(Rhodopseudomonas
palustris) 		PF01565
(FAD_binding_4)
PF02913
(FAD-oxidase_C) 		5 ILE A 468
MET A 469
LEU A  77
ILE A  99
ILE A 215
 None
None
None
None
FAD  A 476 (-4.6A)
 1.07A 3zosA-3pm9A:
undetectable		 3zosA-3pm9A:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rgg PHOSPHORIBOSYLAMINOI
MIDAZOLE
CARBOXYLASE, PURE
PROTEIN

(Treponema
denticola) 		PF00731
(AIRC) 		5 ILE A  30
ILE A   7
ILE A   6
MET A  49
ILE A  34
 None
 1.13A 3zosA-3rggA:
undetectable		 3zosA-3rggA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3te6 REGULATORY PROTEIN
SIR3

(Saccharomyces
cerevisiae) 		no annotation 5 LEU A 574
ILE A 693
ILE A 694
MET A 593
ILE A 665
 None
 0.88A 3zosA-3te6A:
undetectable		 3zosA-3te6A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uho GLUTAMATE RACEMASE

(Campylobacter
jejuni) 		PF01177
(Asp_Glu_race) 		5 ILE A  68
LEU A  66
ILE A  63
ILE A   3
ILE A  29
 None
 0.98A 3zosA-3uhoA:
undetectable		 3zosA-3uhoA:
21.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3v5q NT-3 GROWTH FACTOR
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ILE A 600
MET A 615
TYR A 619
MET A 620
ILE A 695
 0F4  A 902 (-4.1A)
None
0F4  A 902 (-4.2A)
None
0F4  A 902 (-4.6A)
 0.58A 3zosA-3v5qA:
32.9		 3zosA-3v5qA:
45.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vo2 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Zea mays) 		PF00175
(NAD_binding_1) 		5 ILE A 166
LEU A 168
ILE A 281
MET A 297
ILE A 284
 None
 1.15A 3zosA-3vo2A:
undetectable		 3zosA-3vo2A:
20.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zfx EPHRIN TYPE-B
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ILE A 671
MET A 672
ILE A 680
ILE A 681
MET A 700
 None
 0.66A 3zosA-3zfxA:
30.5		 3zosA-3zfxA:
37.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4af3 AURORA KINASE B

(Homo sapiens) 		PF00069
(Pkinase) 		5 ILE A 128
LEU A 132
ILE A 137
TYR A 156
ILE A 216
 None
None
None
VX6  A 500 (-4.2A)
None
 1.01A 3zosA-4af3A:
19.5		 3zosA-4af3A:
26.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4asy GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E

(Pseudomonas
aeruginosa) 		PF00483
(NTP_transferase) 		5 LEU A 106
ILE A   6
ILE A   7
TYR A  37
ILE A  54
 None
 0.96A 3zosA-4asyA:
undetectable		 3zosA-4asyA:
22.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4at3 BDNF/NT-3 GROWTH
FACTORS RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ILE A 616
MET A 631
TYR A 635
MET A 636
ILE A 708
 None
None
LTI  A1839 (-4.7A)
None
None
 0.65A 3zosA-4at3A:
31.8		 3zosA-4at3A:
47.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4aw5 EPHRIN TYPE-B
RECEPTOR 4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ILE A 143
MET A 144
ILE A 152
ILE A 153
MET A 172
 None
 0.66A 3zosA-4aw5A:
24.6		 3zosA-4aw5A:
37.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b99 MITOGEN-ACTIVATED
PROTEIN KINASE 7

(Homo sapiens) 		PF00069
(Pkinase) 		5 ILE A 105
ILE A 114
ILE A 115
MET A 140
ILE A 198
 None
None
R4L  A1394 (-4.9A)
None
None
 0.92A 3zosA-4b99A:
6.7		 3zosA-4b99A:
26.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ckr EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 ILE A 675
MET A 676
LEU A 679
ILE A 684
ILE A 685
MET A 699
TYR A 703
MET A 704
ILE A 782
 None
DI1  A1000 (-3.6A)
DI1  A1000 (-4.5A)
DI1  A1000 ( 4.5A)
DI1  A1000 (-4.5A)
DI1  A1000 ( 4.1A)
DI1  A1000 (-4.0A)
None
DI1  A1000 (-4.5A)
 0.46A 3zosA-4ckrA:
34.5		 3zosA-4ckrA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f0g SERINE/THREONINE-PRO
TEIN KINASE ROCO4

(Dictyostelium
discoideum) 		PF07714
(Pkinase_Tyr) 		5 ILE A1081
MET A1082
LEU A1085
ILE A1090
MET A1103
 None
 0.77A 3zosA-4f0gA:
25.5		 3zosA-4f0gA:
29.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4f0i HIGH AFFINITY NERVE
GROWTH FACTOR
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ILE A 571
MET A 586
TYR A 590
MET A 591
ILE A 665
 None
 0.56A 3zosA-4f0iA:
33.5		 3zosA-4f0iA:
44.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fr4 SERINE/THREONINE-PRO
TEIN KINASE 32A

(Homo sapiens) 		PF00069
(Pkinase) 		5 ILE A  74
MET A  75
LEU A  78
MET A  98
ILE A 162
 None
 1.08A 3zosA-4fr4A:
20.7		 3zosA-4fr4A:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ho4 GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E

(Aneurinibacillus
thermoaerophilus) 		PF00483
(NTP_transferase) 		5 LEU A 104
ILE A   4
ILE A   5
TYR A  35
ILE A  52
 None
 0.95A 3zosA-4ho4A:
undetectable		 3zosA-4ho4A:
26.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hvi TYROSINE-PROTEIN
KINASE JAK3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ILE A 874
LEU A 878
ILE A 883
TYR A 904
ILE A 965
 None
None
None
19S  A1201 (-4.7A)
None
 0.62A 3zosA-4hviA:
22.8		 3zosA-4hviA:
33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4k33 FIBROBLAST GROWTH
FACTOR RECEPTOR 3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 MET A 529
ILE A 538
ILE A 539
TYR A 557
ILE A 633
 None
 0.70A 3zosA-4k33A:
30.4		 3zosA-4k33A:
34.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mvf CALCIUM-DEPENDENT
PROTEIN KINASE 2

(Plasmodium
falciparum) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		5 ILE A 120
MET A 121
LEU A 124
ILE A 129
ILE A 211
 None
 0.78A 3zosA-4mvfA:
19.1		 3zosA-4mvfA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ILE A 950
ILE A 959
ILE A 960
TYR A 980
ILE A1039
 None
None
None
2TT  A1202 (-4.6A)
None
 0.58A 3zosA-4oliA:
26.1		 3zosA-4oliA:
20.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p2k EPHRIN TYPE-A
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		5 ILE A 666
ILE A 675
ILE A 676
TYR A 694
MET A 695
 None
 0.74A 3zosA-4p2kA:
30.0		 3zosA-4p2kA:
36.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p2k EPHRIN TYPE-A
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		5 MET A 667
ILE A 675
ILE A 676
TYR A 694
MET A 695
 None
 0.92A 3zosA-4p2kA:
30.0		 3zosA-4p2kA:
36.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q7l UNCHARACTERIZED ABC
TRANSPORTER
ATP-BINDING PROTEIN
TM_0288

(Thermotoga
maritima) 		PF00005
(ABC_tran) 		5 ILE A 560
LEU A 386
ILE A 545
MET A 534
ILE A 514
 None
 1.05A 3zosA-4q7lA:
undetectable		 3zosA-4q7lA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4red 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1

(Homo sapiens) 		PF00069
(Pkinase) 		5 ILE A  78
ILE A  79
MET A  93
TYR A  97
ILE A 157
 None
 0.65A 3zosA-4redA:
13.8		 3zosA-4redA:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rew 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1

(Homo sapiens) 		PF00069
(Pkinase)
PF16579
(AdenylateSensor) 		5 ILE A  78
ILE A  79
MET A  93
TYR A  97
ILE A 157
 None
STU  A 601 ( 4.6A)
None
STU  A 601 (-4.4A)
None
 0.69A 3zosA-4rewA:
22.1		 3zosA-4rewA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xrl MITOGEN-ACTIVATED
PROTEIN KINASE 1

(Rattus
norvegicus) 		PF00069
(Pkinase) 		5 ILE A  72
ILE A  81
ILE A  82
MET A 106
ILE A 163
 None
 0.91A 3zosA-4xrlA:
20.9		 3zosA-4xrlA:
26.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zev PFHAD1

(Plasmodium
falciparum) 		PF08282
(Hydrolase_3) 		5 LEU A 234
ILE A  24
ILE A  23
TYR A 225
ILE A  55
 None
 1.15A 3zosA-4zevA:
undetectable		 3zosA-4zevA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zkt BONTOXILYSIN A

(Clostridium
botulinum) 		PF01742
(Peptidase_M27)
PF07951
(Toxin_R_bind_C)
PF07952
(Toxin_trans)
PF07953
(Toxin_R_bind_N) 		5 ILE A  90
ILE A  35
ILE A  41
TYR A  30
ILE A  39
 None
 1.01A 3zosA-4zktA:
undetectable		 3zosA-4zktA:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5awm STRESS-ACTIVATED
PROTEIN KINASE JNK

(Drosophila
melanogaster) 		PF00069
(Pkinase) 		5 MET A  75
ILE A  83
ILE A  84
MET A 109
ILE A 165
 None
 0.67A 3zosA-5awmA:
18.9		 3zosA-5awmA:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b48 2-OXOACID--FERREDOXI
N OXIDOREDUCTASE
ALPHA SUBUNIT

(Sulfurisphaera
tokodaii) 		PF01558
(POR)
PF01855
(POR_N) 		5 ILE A 509
LEU A 543
ILE A 520
ILE A 519
ILE A 566
 None
 1.07A 3zosA-5b48A:
undetectable		 3zosA-5b48A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5es1 MAP/MICROTUBULE
AFFINITY-REGULATING
KINASE 4

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		5 ILE A 106
LEU A 110
ILE A 115
TYR A 134
ILE A 194
 None
None
None
5RC  A4000 (-4.5A)
None
 0.82A 3zosA-5es1A:
22.4		 3zosA-5es1A:
25.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ILE A 950
ILE A 959
ILE A 960
TYR A 980
ILE A1039
 None
None
5U3  A1200 (-4.6A)
5U3  A1200 (-4.5A)
None
 0.45A 3zosA-5f1zA:
27.0		 3zosA-5f1zA:
34.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ILE A 950
LEU A 954
ILE A 959
TYR A 980
ILE A1039
 None
None
None
5U3  A1200 (-4.5A)
None
 0.74A 3zosA-5f1zA:
27.0		 3zosA-5f1zA:
34.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f64 POSITIVE
TRANSCRIPTION
REGULATOR EVGA

(Shigella
flexneri) 		PF00072
(Response_reg)
PF00196
(GerE) 		5 ILE A  13
ILE A   6
ILE A  50
MET A 106
ILE A   4
 None
 1.14A 3zosA-5f64A:
undetectable		 3zosA-5f64A:
19.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ILE A 647
MET A 648
ILE A 657
TYR A 676
ILE A 834
 748  A1001 ( 4.0A)
748  A1001 (-3.4A)
748  A1001 ( 4.4A)
748  A1001 (-4.0A)
748  A1001 (-4.8A)
 0.85A 3zosA-5grnA:
28.0		 3zosA-5grnA:
30.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hab RIBONUCLEASE J

(Methanolobus
psychrophilus) 		PF07521
(RMMBL)
PF12706
(Lactamase_B_2) 		5 ILE A 103
ILE A  31
ILE A  30
MET A  68
ILE A  22
 None
 1.09A 3zosA-5habA:
undetectable		 3zosA-5habA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5idt GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E

(Burkholderia
vietnamiensis) 		PF00483
(NTP_transferase) 		5 LEU A 107
ILE A   7
ILE A   8
TYR A  38
ILE A  55
 None
 0.92A 3zosA-5idtA:
undetectable		 3zosA-5idtA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ify GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E

(Burkholderia
vietnamiensis) 		PF00483
(NTP_transferase) 		5 LEU A 106
ILE A   6
ILE A   7
TYR A  37
ILE A  54
 None
 0.98A 3zosA-5ifyA:
undetectable		 3zosA-5ifyA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ig1 CAMK/CAMK2 PROTEIN
KINASE

(Salpingoeca
rosetta) 		PF00069
(Pkinase) 		5 ILE A  68
LEU A  72
ILE A  77
TYR A  96
ILE A 159
 None
None
None
PO4  A 401 (-4.8A)
None
 0.75A 3zosA-5ig1A:
23.0		 3zosA-5ig1A:
26.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iw7 RIBOSOME BIOGENESIS
PROTEIN
TSR1,RIBOSOME
BIOGENESIS PROTEIN
TSR1

(Saccharomyces
cerevisiae) 		PF04950
(RIBIOP_C)
PF08142
(AARP2CN) 		5 ILE A 100
ILE A 137
ILE A 138
MET A 142
ILE A  86
 None
 1.15A 3zosA-5iw7A:
undetectable		 3zosA-5iw7A:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jwb TYPE II
NADH:UBIQUINONE
OXIDOREDUCTASE

(Plasmodium
falciparum) 		PF07992
(Pyr_redox_2) 		5 ILE A  69
LEU A  46
ILE A 146
ILE A 145
ILE A 349
 None
FAD  A 601 ( 4.4A)
None
None
None
 1.01A 3zosA-5jwbA:
undetectable		 3zosA-5jwbA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k5z PARA

(Sulfolobus sp.
NOB8H2) 		PF13614
(AAA_31) 		5 ILE A 204
LEU A 161
ILE A 200
MET A 174
ILE A 237
 None
 1.04A 3zosA-5k5zA:
undetectable		 3zosA-5k5zA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5llb POLYPHOSPHATE KINASE
2

(Francisella
tularensis) 		no annotation 5 ILE C  85
ILE C  57
ILE C  56
MET C  74
ILE C 159
 None
 1.01A 3zosA-5llbC:
undetectable		 3zosA-5llbC:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mjk THIOREDOXIN
REDUCTASE

(Lactococcus
lactis) 		PF07992
(Pyr_redox_2) 		5 LEU A  34
ILE A  11
ILE A  10
TYR A  23
ILE A 107
 None
 1.10A 3zosA-5mjkA:
undetectable		 3zosA-5mjkA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mp2 TYPE II SECRETION
SYSTEM PROTEIN D

(Pseudomonas
aeruginosa) 		no annotation 5 ILE A 160
LEU A 173
ILE A 184
ILE A 183
ILE A 149
 None
 0.89A 3zosA-5mp2A:
undetectable		 3zosA-5mp2A:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nbr DEOXYRIBOSYLTRANSFER
ASE

(Leishmania
mexicana) 		PF05014
(Nuc_deoxyrib_tr) 		5 LEU A  97
ILE A  67
ILE A  66
TYR A  88
ILE A   7
 None
 1.14A 3zosA-5nbrA:
undetectable		 3zosA-5nbrA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nck N-ACETYLMANNOSAMINE
KINASE

(Fusobacterium
nucleatum) 		PF00480
(ROK) 		5 ILE A 132
LEU A 233
ILE A 231
ILE A 232
ILE A 128
 None
 1.01A 3zosA-5nckA:
undetectable		 3zosA-5nckA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u8s DNA REPLICATION
LICENSING FACTOR
MCM4

(Saccharomyces
cerevisiae) 		PF00493
(MCM)
PF14551
(MCM_N)
PF17207
(MCM_OB) 		5 ILE 4 829
LEU 4 704
ILE 4 564
MET 4 649
ILE 4 562
 None
 1.15A 3zosA-5u8s4:
2.1		 3zosA-5u8s4:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wnm RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 4

(Mus musculus) 		no annotation 5 MET A  73
ILE A  81
TYR A  98
MET A  99
ILE A 159
 None
None
VX6  A 402 (-4.3A)
None
None
 0.71A 3zosA-5wnmA:
25.6		 3zosA-5wnmA:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wzk PUMILIO HOMOLOG 23

(Arabidopsis
thaliana) 		no annotation 5 ILE A 381
MET A 382
LEU A 353
ILE A 366
ILE A 370
 None
 1.13A 3zosA-5wzkA:
2.1		 3zosA-5wzkA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b5e GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E

(Mycobacterium
tuberculosis) 		no annotation 5 LEU A 104
ILE A   4
ILE A   5
TYR A  35
ILE A  52
 None
 0.97A 3zosA-6b5eA:
undetectable		 3zosA-6b5eA:
12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bx6 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2

(Homo sapiens) 		no annotation 5 ILE A  76
ILE A  77
MET A  91
TYR A  95
ILE A 155
 None
EDJ  A 301 ( 4.7A)
None
EDJ  A 301 ( 4.8A)
None
 0.52A 3zosA-6bx6A:
18.8		 3zosA-6bx6A:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c9d SERINE/THREONINE-PRO
TEIN KINASE
MARK1,SERINE/THREONI
NE-PROTEIN KINASE
MARK1

(Homo sapiens) 		no annotation 5 ILE A 110
LEU A 114
ILE A 119
TYR A 138
ILE A 198
 None
 0.79A 3zosA-6c9dA:
21.2		 3zosA-6c9dA:
11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c9d SERINE/THREONINE-PRO
TEIN KINASE
MARK1,SERINE/THREONI
NE-PROTEIN KINASE
MARK1

(Homo sapiens) 		no annotation 5 ILE A 110
MET A 111
ILE A 119
TYR A 138
ILE A 198
 None
 0.97A 3zosA-6c9dA:
21.2		 3zosA-6c9dA:
11.78